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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MDM2-PPM1H (FusionGDB2 ID:52415)

Fusion Gene Summary for MDM2-PPM1H

check button Fusion gene summary
Fusion gene informationFusion gene name: MDM2-PPM1H
Fusion gene ID: 52415
HgeneTgene
Gene symbol

MDM2

PPM1H

Gene ID

4193

57460

Gene nameMDM2 proto-oncogeneprotein phosphatase, Mg2+/Mn2+ dependent 1H
SynonymsACTFS|HDMX|LSKB|hdm2ARHCL1|NERPP-2C|URCC2
Cytomap

12q15

12q14.1-q14.2

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase Mdm2MDM2 oncogene, E3 ubiquitin protein ligaseMDM2 proto-oncogene, E3 ubiquitin protein ligaseMdm2, p53 E3 ubiquitin protein ligase homologMdm2, transformed 3T3 cell double minute 2, p53 binding proteindouble minute 2, humprotein phosphatase 1Hneurite extension-related protein phosphatase related to PP2Cprotein phosphatase 1H (PP2C domain containing)ras homolog gene family, member C like 1
Modification date2020032920200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000258148, ENST00000258149, 
ENST00000299252, ENST00000350057, 
ENST00000356290, ENST00000360430, 
ENST00000462284, ENST00000540827, 
ENST00000348801, ENST00000393410, 
ENST00000393412, ENST00000393413, 
ENST00000428863, ENST00000478070, 
ENST00000517852, ENST00000544125, 
ENST00000544561, ENST00000545204, 
ENST00000551214, ENST00000228705, 
Fusion gene scores* DoF score39 X 20 X 11=858012 X 10 X 6=720
# samples 4711
** MAII scorelog2(47/8580*10)=-4.19024498582191
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/720*10)=-2.71049338280502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MDM2 [Title/Abstract] AND PPM1H [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMDM2(69230529)-PPM1H(63195940), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMDM2

GO:0000122

negative regulation of transcription by RNA polymerase II

9271120|17310983

HgeneMDM2

GO:0006511

ubiquitin-dependent protein catabolic process

11278372|15314173|16173922|17310983

HgeneMDM2

GO:0016567

protein ubiquitination

9450543|15878855|19656744|20153724

HgeneMDM2

GO:0031648

protein destabilization

9529249|10360174|15314173

HgeneMDM2

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

11278372

HgeneMDM2

GO:0034504

protein localization to nucleus

10360174

HgeneMDM2

GO:0042176

regulation of protein catabolic process

9153395

HgeneMDM2

GO:0043518

negative regulation of DNA damage response, signal transduction by p53 class mediator

9529249|10360174

HgeneMDM2

GO:0045184

establishment of protein localization

10360174

HgeneMDM2

GO:0045892

negative regulation of transcription, DNA-templated

9271120

HgeneMDM2

GO:0065003

protein-containing complex assembly

10608892|12915590

HgeneMDM2

GO:0071157

negative regulation of cell cycle arrest

9529249

HgeneMDM2

GO:0071480

cellular response to gamma radiation

16213212

HgeneMDM2

GO:0072717

cellular response to actinomycin D

15314173

HgeneMDM2

GO:1901797

negative regulation of signal transduction by p53 class mediator

16173922


check buttonFusion gene breakpoints across MDM2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PPM1H (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-19-2624MDM2chr12

69230529

+PPM1Hchr12

63195940

-


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Fusion Gene ORF analysis for MDM2-PPM1H

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000258148ENST00000551214MDM2chr12

69230529

+PPM1Hchr12

63195940

-
5CDS-intronENST00000258149ENST00000551214MDM2chr12

69230529

+PPM1Hchr12

63195940

-
5CDS-intronENST00000299252ENST00000551214MDM2chr12

69230529

+PPM1Hchr12

63195940

-
5CDS-intronENST00000350057ENST00000551214MDM2chr12

69230529

+PPM1Hchr12

63195940

-
5CDS-intronENST00000356290ENST00000551214MDM2chr12

69230529

+PPM1Hchr12

63195940

-
5CDS-intronENST00000360430ENST00000551214MDM2chr12

69230529

+PPM1Hchr12

63195940

-
5CDS-intronENST00000462284ENST00000551214MDM2chr12

69230529

+PPM1Hchr12

63195940

-
5CDS-intronENST00000540827ENST00000551214MDM2chr12

69230529

+PPM1Hchr12

63195940

-
In-frameENST00000258148ENST00000228705MDM2chr12

69230529

+PPM1Hchr12

63195940

-
In-frameENST00000258149ENST00000228705MDM2chr12

69230529

+PPM1Hchr12

63195940

-
In-frameENST00000299252ENST00000228705MDM2chr12

69230529

+PPM1Hchr12

63195940

-
In-frameENST00000350057ENST00000228705MDM2chr12

69230529

+PPM1Hchr12

63195940

-
In-frameENST00000356290ENST00000228705MDM2chr12

69230529

+PPM1Hchr12

63195940

-
In-frameENST00000360430ENST00000228705MDM2chr12

69230529

+PPM1Hchr12

63195940

-
In-frameENST00000462284ENST00000228705MDM2chr12

69230529

+PPM1Hchr12

63195940

-
In-frameENST00000540827ENST00000228705MDM2chr12

69230529

+PPM1Hchr12

63195940

-
intron-3CDSENST00000348801ENST00000228705MDM2chr12

69230529

+PPM1Hchr12

63195940

-
intron-3CDSENST00000393410ENST00000228705MDM2chr12

69230529

+PPM1Hchr12

63195940

-
intron-3CDSENST00000393412ENST00000228705MDM2chr12

69230529

+PPM1Hchr12

63195940

-
intron-3CDSENST00000393413ENST00000228705MDM2chr12

69230529

+PPM1Hchr12

63195940

-
intron-3CDSENST00000428863ENST00000228705MDM2chr12

69230529

+PPM1Hchr12

63195940

-
intron-3CDSENST00000478070ENST00000228705MDM2chr12

69230529

+PPM1Hchr12

63195940

-
intron-3CDSENST00000517852ENST00000228705MDM2chr12

69230529

+PPM1Hchr12

63195940

-
intron-3CDSENST00000544125ENST00000228705MDM2chr12

69230529

+PPM1Hchr12

63195940

-
intron-3CDSENST00000544561ENST00000228705MDM2chr12

69230529

+PPM1Hchr12

63195940

-
intron-3CDSENST00000545204ENST00000228705MDM2chr12

69230529

+PPM1Hchr12

63195940

-
intron-intronENST00000348801ENST00000551214MDM2chr12

69230529

+PPM1Hchr12

63195940

-
intron-intronENST00000393410ENST00000551214MDM2chr12

69230529

+PPM1Hchr12

63195940

-
intron-intronENST00000393412ENST00000551214MDM2chr12

69230529

+PPM1Hchr12

63195940

-
intron-intronENST00000393413ENST00000551214MDM2chr12

69230529

+PPM1Hchr12

63195940

-
intron-intronENST00000428863ENST00000551214MDM2chr12

69230529

+PPM1Hchr12

63195940

-
intron-intronENST00000478070ENST00000551214MDM2chr12

69230529

+PPM1Hchr12

63195940

-
intron-intronENST00000517852ENST00000551214MDM2chr12

69230529

+PPM1Hchr12

63195940

-
intron-intronENST00000544125ENST00000551214MDM2chr12

69230529

+PPM1Hchr12

63195940

-
intron-intronENST00000544561ENST00000551214MDM2chr12

69230529

+PPM1Hchr12

63195940

-
intron-intronENST00000545204ENST00000551214MDM2chr12

69230529

+PPM1Hchr12

63195940

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000462284MDM2chr1269230529+ENST00000228705PPM1Hchr1263195940-686112202662353695
ENST00000356290MDM2chr1269230529+ENST00000228705PPM1Hchr1263195940-63366952511828525
ENST00000540827MDM2chr1269230529+ENST00000228705PPM1Hchr1263195940-62616202511753500
ENST00000258149MDM2chr1269230529+ENST00000228705PPM1Hchr1263195940-668110402512173640
ENST00000258148MDM2chr1269230529+ENST00000228705PPM1Hchr1263195940-6408767141900628
ENST00000350057MDM2chr1269230529+ENST00000228705PPM1Hchr1263195940-646682501958652
ENST00000360430MDM2chr1269230529+ENST00000228705PPM1Hchr1263195940-595631501448482
ENST00000299252MDM2chr1269230529+ENST00000228705PPM1Hchr1263195940-603139001523507

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000462284ENST00000228705MDM2chr1269230529+PPM1Hchr1263195940-0.0009166120.9990834
ENST00000356290ENST00000228705MDM2chr1269230529+PPM1Hchr1263195940-0.0012191210.9987809
ENST00000540827ENST00000228705MDM2chr1269230529+PPM1Hchr1263195940-0.0007008410.99929917
ENST00000258149ENST00000228705MDM2chr1269230529+PPM1Hchr1263195940-0.0004108030.99958926
ENST00000258148ENST00000228705MDM2chr1269230529+PPM1Hchr1263195940-0.0003948730.9996051
ENST00000350057ENST00000228705MDM2chr1269230529+PPM1Hchr1263195940-0.0005179220.9994821
ENST00000360430ENST00000228705MDM2chr1269230529+PPM1Hchr1263195940-0.0004422940.9995577
ENST00000299252ENST00000228705MDM2chr1269230529+PPM1Hchr1263195940-0.0004263960.99957365

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Fusion Genomic Features for MDM2-PPM1H


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MDM2-PPM1H


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:69230529/chr12:63195940)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMDM2chr12:69230529chr12:63195940ENST00000258149+89210_215245437.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69230529chr12:63195940ENST00000462284+1011210_215306498.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69230529chr12:63195940ENST00000462284+1011243_301306498.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69230529chr12:63195940ENST00000258149+8926_109245437.0DomainSWIB/MDM2
HgeneMDM2chr12:69230529chr12:63195940ENST00000299252+4526_109130322.0DomainSWIB/MDM2
HgeneMDM2chr12:69230529chr12:63195940ENST00000356290+5626_109130322.0DomainSWIB/MDM2
HgeneMDM2chr12:69230529chr12:63195940ENST00000462284+101126_109306498.0DomainSWIB/MDM2
HgeneMDM2chr12:69230529chr12:63195940ENST00000258149+89179_185245437.0MotifNuclear localization signal
HgeneMDM2chr12:69230529chr12:63195940ENST00000258149+89190_202245437.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69230529chr12:63195940ENST00000462284+1011179_185306498.0MotifNuclear localization signal
HgeneMDM2chr12:69230529chr12:63195940ENST00000462284+1011190_202306498.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69230529chr12:63195940ENST00000258149+891_101245437.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69230529chr12:63195940ENST00000299252+451_101130322.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69230529chr12:63195940ENST00000356290+561_101130322.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69230529chr12:63195940ENST00000360430+341_101105297.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69230529chr12:63195940ENST00000462284+10111_101306498.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69230529chr12:63195940ENST00000462284+1011210_304306498.0RegionNote=ARF-binding
HgeneMDM2chr12:69230529chr12:63195940ENST00000540827+451_101105297.0RegionSufficient to promote the mitochondrial pathway of apoptosis

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMDM2chr12:69230529chr12:63195940ENST00000258149+89243_301245437.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69230529chr12:63195940ENST00000299252+45210_215130322.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69230529chr12:63195940ENST00000299252+45243_301130322.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69230529chr12:63195940ENST00000348801+13210_2150266.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69230529chr12:63195940ENST00000348801+13243_3010266.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69230529chr12:63195940ENST00000356290+56210_215130322.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69230529chr12:63195940ENST00000356290+56243_301130322.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69230529chr12:63195940ENST00000360430+34210_215105297.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69230529chr12:63195940ENST00000360430+34243_301105297.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69230529chr12:63195940ENST00000393412+13210_2150219.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69230529chr12:63195940ENST00000393412+13243_3010219.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69230529chr12:63195940ENST00000393413+12210_2150219.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69230529chr12:63195940ENST00000393413+12243_3010219.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69230529chr12:63195940ENST00000428863+14210_2150271.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69230529chr12:63195940ENST00000428863+14243_3010271.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69230529chr12:63195940ENST00000540827+45210_215105297.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69230529chr12:63195940ENST00000540827+45243_301105297.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69230529chr12:63195940ENST00000348801+1326_1090266.0DomainSWIB/MDM2
HgeneMDM2chr12:69230529chr12:63195940ENST00000360430+3426_109105297.0DomainSWIB/MDM2
HgeneMDM2chr12:69230529chr12:63195940ENST00000393412+1326_1090219.0DomainSWIB/MDM2
HgeneMDM2chr12:69230529chr12:63195940ENST00000393413+1226_1090219.0DomainSWIB/MDM2
HgeneMDM2chr12:69230529chr12:63195940ENST00000428863+1426_1090271.0DomainSWIB/MDM2
HgeneMDM2chr12:69230529chr12:63195940ENST00000540827+4526_109105297.0DomainSWIB/MDM2
HgeneMDM2chr12:69230529chr12:63195940ENST00000258149+89466_473245437.0MotifNucleolar localization signal
HgeneMDM2chr12:69230529chr12:63195940ENST00000299252+45179_185130322.0MotifNuclear localization signal
HgeneMDM2chr12:69230529chr12:63195940ENST00000299252+45190_202130322.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69230529chr12:63195940ENST00000299252+45466_473130322.0MotifNucleolar localization signal
HgeneMDM2chr12:69230529chr12:63195940ENST00000348801+13179_1850266.0MotifNuclear localization signal
HgeneMDM2chr12:69230529chr12:63195940ENST00000348801+13190_2020266.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69230529chr12:63195940ENST00000348801+13466_4730266.0MotifNucleolar localization signal
HgeneMDM2chr12:69230529chr12:63195940ENST00000356290+56179_185130322.0MotifNuclear localization signal
HgeneMDM2chr12:69230529chr12:63195940ENST00000356290+56190_202130322.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69230529chr12:63195940ENST00000356290+56466_473130322.0MotifNucleolar localization signal
HgeneMDM2chr12:69230529chr12:63195940ENST00000360430+34179_185105297.0MotifNuclear localization signal
HgeneMDM2chr12:69230529chr12:63195940ENST00000360430+34190_202105297.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69230529chr12:63195940ENST00000360430+34466_473105297.0MotifNucleolar localization signal
HgeneMDM2chr12:69230529chr12:63195940ENST00000393412+13179_1850219.0MotifNuclear localization signal
HgeneMDM2chr12:69230529chr12:63195940ENST00000393412+13190_2020219.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69230529chr12:63195940ENST00000393412+13466_4730219.0MotifNucleolar localization signal
HgeneMDM2chr12:69230529chr12:63195940ENST00000393413+12179_1850219.0MotifNuclear localization signal
HgeneMDM2chr12:69230529chr12:63195940ENST00000393413+12190_2020219.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69230529chr12:63195940ENST00000393413+12466_4730219.0MotifNucleolar localization signal
HgeneMDM2chr12:69230529chr12:63195940ENST00000428863+14179_1850271.0MotifNuclear localization signal
HgeneMDM2chr12:69230529chr12:63195940ENST00000428863+14190_2020271.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69230529chr12:63195940ENST00000428863+14466_4730271.0MotifNucleolar localization signal
HgeneMDM2chr12:69230529chr12:63195940ENST00000462284+1011466_473306498.0MotifNucleolar localization signal
HgeneMDM2chr12:69230529chr12:63195940ENST00000540827+45179_185105297.0MotifNuclear localization signal
HgeneMDM2chr12:69230529chr12:63195940ENST00000540827+45190_202105297.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69230529chr12:63195940ENST00000540827+45466_473105297.0MotifNucleolar localization signal
HgeneMDM2chr12:69230529chr12:63195940ENST00000258149+89210_304245437.0RegionNote=ARF-binding
HgeneMDM2chr12:69230529chr12:63195940ENST00000258149+89242_331245437.0RegionNote=Region II
HgeneMDM2chr12:69230529chr12:63195940ENST00000299252+45210_304130322.0RegionNote=ARF-binding
HgeneMDM2chr12:69230529chr12:63195940ENST00000299252+45242_331130322.0RegionNote=Region II
HgeneMDM2chr12:69230529chr12:63195940ENST00000348801+131_1010266.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69230529chr12:63195940ENST00000348801+13210_3040266.0RegionNote=ARF-binding
HgeneMDM2chr12:69230529chr12:63195940ENST00000348801+13242_3310266.0RegionNote=Region II
HgeneMDM2chr12:69230529chr12:63195940ENST00000356290+56210_304130322.0RegionNote=ARF-binding
HgeneMDM2chr12:69230529chr12:63195940ENST00000356290+56242_331130322.0RegionNote=Region II
HgeneMDM2chr12:69230529chr12:63195940ENST00000360430+34210_304105297.0RegionNote=ARF-binding
HgeneMDM2chr12:69230529chr12:63195940ENST00000360430+34242_331105297.0RegionNote=Region II
HgeneMDM2chr12:69230529chr12:63195940ENST00000393412+131_1010219.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69230529chr12:63195940ENST00000393412+13210_3040219.0RegionNote=ARF-binding
HgeneMDM2chr12:69230529chr12:63195940ENST00000393412+13242_3310219.0RegionNote=Region II
HgeneMDM2chr12:69230529chr12:63195940ENST00000393413+121_1010219.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69230529chr12:63195940ENST00000393413+12210_3040219.0RegionNote=ARF-binding
HgeneMDM2chr12:69230529chr12:63195940ENST00000393413+12242_3310219.0RegionNote=Region II
HgeneMDM2chr12:69230529chr12:63195940ENST00000428863+141_1010271.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69230529chr12:63195940ENST00000428863+14210_3040271.0RegionNote=ARF-binding
HgeneMDM2chr12:69230529chr12:63195940ENST00000428863+14242_3310271.0RegionNote=Region II
HgeneMDM2chr12:69230529chr12:63195940ENST00000462284+1011242_331306498.0RegionNote=Region II
HgeneMDM2chr12:69230529chr12:63195940ENST00000540827+45210_304105297.0RegionNote=ARF-binding
HgeneMDM2chr12:69230529chr12:63195940ENST00000540827+45242_331105297.0RegionNote=Region II
HgeneMDM2chr12:69230529chr12:63195940ENST00000258149+89299_328245437.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69230529chr12:63195940ENST00000258149+89438_479245437.0Zinc fingerRING-type
HgeneMDM2chr12:69230529chr12:63195940ENST00000299252+45299_328130322.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69230529chr12:63195940ENST00000299252+45438_479130322.0Zinc fingerRING-type
HgeneMDM2chr12:69230529chr12:63195940ENST00000348801+13299_3280266.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69230529chr12:63195940ENST00000348801+13438_4790266.0Zinc fingerRING-type
HgeneMDM2chr12:69230529chr12:63195940ENST00000356290+56299_328130322.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69230529chr12:63195940ENST00000356290+56438_479130322.0Zinc fingerRING-type
HgeneMDM2chr12:69230529chr12:63195940ENST00000360430+34299_328105297.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69230529chr12:63195940ENST00000360430+34438_479105297.0Zinc fingerRING-type
HgeneMDM2chr12:69230529chr12:63195940ENST00000393412+13299_3280219.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69230529chr12:63195940ENST00000393412+13438_4790219.0Zinc fingerRING-type
HgeneMDM2chr12:69230529chr12:63195940ENST00000393413+12299_3280219.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69230529chr12:63195940ENST00000393413+12438_4790219.0Zinc fingerRING-type
HgeneMDM2chr12:69230529chr12:63195940ENST00000428863+14299_3280271.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69230529chr12:63195940ENST00000428863+14438_4790271.0Zinc fingerRING-type
HgeneMDM2chr12:69230529chr12:63195940ENST00000462284+1011299_328306498.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69230529chr12:63195940ENST00000462284+1011438_479306498.0Zinc fingerRING-type
HgeneMDM2chr12:69230529chr12:63195940ENST00000540827+45299_328105297.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69230529chr12:63195940ENST00000540827+45438_479105297.0Zinc fingerRING-type
TgenePPM1Hchr12:69230529chr12:63195940ENST0000022870511077_507137515.0DomainPPM-type phosphatase


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Fusion Gene Sequence for MDM2-PPM1H


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>52415_52415_1_MDM2-PPM1H_MDM2_chr12_69230529_ENST00000258148_PPM1H_chr12_63195940_ENST00000228705_length(transcript)=6408nt_BP=767nt
CGCGAAAACCCCGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTC
CAGCTTCGGAACAAGAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATACTA
TGAAAGAGGTTCTTTTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATG
ATCTTCTAGGAGATTTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAG
TCAATCAGCAGGAAGAAAATTCAGATGAATTATCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTGATG
AAAGCCTGGCTCTGTGTGTAATAAGGGAGATATGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGGATCTTG
ATGCTGGTGTAAGTGAACATTCAGGTGATTGGTTGGATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAATTTGAAGTTGAATCTCTCG
ACTCAGAAGATTATAGCCTTAGTGAAGAAGGACAAGAACTCTCAGATGAAGATGATGAGGTATATCAAGTTACTGTGTATCAGGCAGGGG
AGAGTGATACAGATTCATTTGAAGAAGATCCTGAAATTTCCTTAGCTGAATCCGAGGGTGTTTCCTGCCACTATTGGTCGCTGTTTGACG
GGCACGCGGGGTCCGGGGCCGCGGTGGTGGCGTCACGCCTGCTGCAGCACCACATCACGGAGCAGCTGCAGGACATCGTGGACATCCTGA
AGAACTCCGCCGTCCTGCCCCCTACCTGCCTGGGGGAGGAGCCTGAGAACACGCCCGCCAACAGCCGGACTCTGACCCGGGCAGCCTCCC
TGCGCGGAGGGGTGGGGGCCCCGGGCTCCCCCAGCACGCCCCCCACACGCTTCTTTACCGAGAAGAAGATTCCCCATGAGTGCCTGGTCA
TCGGAGCGCTTGAAAGTGCATTCAAGGAAATGGACCTACAGATAGAACGAGAGAGGAGTTCATATAATATATCTGGTGGCTGCACGGCCC
TCATTGTGATTTGCCTTTTGGGGAAGCTGTATGTTGCAAATGCTGGGGATAGCAGGGCCATAATCATCAGAAATGGAGAAATTATCCCCA
TGTCTTCAGAATTTACCCCCGAGACGGAGCGCCAGCGACTTCAGTACCTGGCATTCATGCAGCCTCACTTGCTGGGAAATGAGTTCACAC
ATTTGGAGTTTCCAAGGAGAGTACAGAGAAAGGAGCTTGGAAAGAAGATGCTCTACAGGGACTTTAATATGACAGGCTGGGCATACAAAA
CCATTGAGGATGAGGACTTGAAGTTCCCCCTTATATATGGAGAAGGCAAGAAGGCCCGGGTAATGGCAACTATTGGAGTGACCAGGGGAC
TTGGGGACCATGACCTGAAGGTGCATGACTCCAACATCTACATTAAACCATTCCTGTCTTCAGCTCCAGAGGTAAGAATCTACGATCTTT
CAAAATATGATCATGGATCAGATGATGTGCTGATCTTGGCCACTGATGGACTCTGGGACGTTTTATCAAATGAAGAAGTAGCAGAAGCAA
TCACTCAGTTTCTTCCTAACTGTGATCCAGATGATCCTCACAGGTACACACTGGCAGCTCAGGACCTGGTGATGCGTGCCCGGGGTGTGC
TGAAGGACAGAGGATGGCGGATATCTAATGACCGACTGGGCTCAGGAGACGACATTTCTGTATATGTCATTCCTTTAATACATGGAAACA
AGCTGTCATGAAAATGGCCCAGGGGATTGGGAGGACAGAGGGGAAGAAAGCTGGGATGCCTCTTGGCAGGACGGAACTGGGAAGTGCCCC
AGCTGAGTTCCAAGTGATGCAGTCTCTTCCCAGCCCAAGCGGGGAGTTCATGGCCAAAAGACTATGCTTCAAGATGACCCTTTGGTTTCC
ATTTCTTCTTTAGTAACAGGTCAACTCAACAAGAGCAAAACACAAAGGCTGCTACCAAGTGTTGTTGTATTTCAGTTCCTTTCATAGGCC
TCCGAGGTGGCCATTGACTATTTGGGGTATATATGTCATATTTATTTTATCTAGAGTAGCTGGGGCAGCCATTTTCAGGTGTAAATGGCA
GAGGACTCTTCAGCCTGTCAAGCTGCCAGCTTATCTACGGGTTAAAAAGTGCTGCATTGGAAAGTAGGGGGTCATGCCTCAAAATGTAAG
TAAGTGCCCACCTTCTAGGAAGCCTGAGGTTTATTTCAGGGATTGCCGTCTGCCCCCCGCCCCCCTTCTCTTTTTTTCTTCTCTGTTTCT
ATTCTTTTATGGCAGTGGTGGAGTGAGGCAGGGATTTTTTTTTTTTTTTTTCGTGTTTTTGACATTCCTTGAATCTGTTTTTTATTCCCC
TTCCACAGAACAGGCCTGGGACTTTCCAACACCCTGCTAAGGAAGTTCTGTGTCCAAGTCCCACCCAGGCTGGGTTGTCCCCACCTCCTC
CAGCCCACACAGCCCAGGCAGCATCCGGGCCAGTGCCCTGCATGACAGAGGGTCTTTGTTGTGTAATGTTTGTTCCCAAGTTGCATTTTC
TAACCGAATCAGTGTGTTTTCATGAAACTGAGTGTTTCTGTGGACCAGTAGTTCCTCTGTTGTCTTCAGTGGTCTTCCTGTGTGGCTCAA
GGGTTCTCTGTGAGAGTCTGGATTTTCATTTCTGGAATGGCTGGCCCCATCCCACTTTTCTGTATCATGGGGACACATATAAAGCAGTGT
TTAATAGAGCAGTTTAAGAAGTTGCTTGCATCTGTTGGTTCACCATGGCTCATCTGGGGACCATTTTGGATTCATGTTTCATGGCTTGTG
ACTGTCCCCAAGCCCACTCCAAACAAAGTGTAAGGATCAGAGTTCTGTCAAGGAGCAGCAGTTCTGCTCTCCCCATCATCTTTGTGCAAG
GCCCCTCGGGGGGCACTTTAATAAAAGAATTTGAAATGGGTTGACTGGCCATTCTCATGCTGTGCTCCCTGTCTCTTCTCTTCTCTAAAG
AATCATGTCCCAGCTCCTCAAGGTCCCTCTATGGTTCCACATCTGAGTGTTCGCCACAAGAGCAGCAGCAGCAGGCACAGTGCATGCCAT
ATCTACCTGCTGCTTCTCTGCTGGGAGGAATGGCCAAGTAGATTATAAAACTCACTTCTGTCTCTTAGGCAGACTTGTACGGCCACAAAA
TTACCTAGTCTTCTTCCTGCTGAGCTACTGAGGTATTGCCACCATTTTGACAACTTTGAGTAATTAAAACACTCTTCTGACCCAAAAAGG
AAAAAAGGTCACTGACGTGACCCCCCCAGCATGCTAGAGAGCTAATTCCAGTTCTCATATTTGTTTGAATTTCTTCCCAGAGGAGAGGAT
AGGAACCTCTCCTCCAGGGCAGTAAATCACCTGCATTTCTGGAGTTGTCGGTATTGTATTCGAAAAGGCCTGGAGCCCCTCCTGCTCAGG
AAAGAACTCATTCCAGGGTGTGGAGACAGTGCCGTCTGGCAGGTGAAATACTGTGGGAATTCACGCCACCAGGTGTTTGTGCAAGTGTTG
GCCTGGGAAGAATGGGACTTCGGCCTTGTCAGGAGTTGTCTTCATCTGCAGCACGTTTCTTCCTCCTGCAGTAGATCTTAGCTACCCCAG
ATATCTCTATGGAGAGAAGTTTGTGGAAAATGCTTTGCTTCGTGGCAGAGTCTGATGCTGTAGGAAAACCTTCGGGCATGTGACAGCAGT
GTGGTCCACTCCCTGTTCTGCCCTGGCACTCAGAGTCATGTGTAAGTAGGAAACCTGAGCAAGTCTTCCGTGGAGGACCCTGAGCTGCCG
TCTTTGGGATCCTTCCTGTGTCCCCACCGTCTTTCATTTATTTGCTTTCCTGGGCCTCTATCTGGGCCCTACCTTGAGCTTCTCCAGTTT
TATTCAAGCCACCAGAGTAAGAATTTGGGTGTAGATGTCACAACTACCTTCTACTCAATTCACCAATTCATTTACTGCTATGGCACGTCT
CAGGAATAACTCTAGAAACCTCTAAATCGAAATATTATAAAATCTTGAGCACTTAGTCCTGCTGGTTTTAGTTAGAAAGGCATCCAGGAA
TTGTTTTCCTACGCCCCCTTGAGTGGAAAGATCTTAGTTAGAAGATAAAGTCAAGTTTGTGTTCAGGGGATGGGAGGAAGACTATAAATA
AGATGAAGAAATCAAAAGTAGGAAACATGATGTAAACGAAGCATGGCAGATCTGTCCAGCACTGATATTGCTCTATAAATTGAGCTTACT
CAGTTTTGGCCTTATTTTTTTACCCAGGCCCCATGTCACCCAGTCCTAAAACAGTAACCGTGTCTACATAACGGGTTGGCCCCTGGTGCA
TCCCTGGAAAAGTCAAAGGACGCACACTTCGAAATTCTGCAGAACGTATTTATACATGGTTCAGAAATCTTGCGTATCTGACTTATAGCC
AAATCTGCTTGCTCGAATAGCCTCAGAGGAAGTCTTGTTTAATAAAAACCTTTTGATTTCCTAGTCAAGTCTTTATGGTTGTCTCGAGGG
GTGTGTGGCTACTTTAATGAAAGGCTTTCCTGCTCTAAATCTCTTTGCTGGGCTGGGCCTCTTCAGACTATCTGGTGAAACTCCTTTCCT
TAGAACAAACTCAGTCCGTCCATGCTCTGTGGCATTTTGCTAGATGATAACCAAAGCCTTATTCCTGTAGCCAGTGTCAGCAGTCAGAGA
GGTGGAGGGTGTGTTCTGCTGTGGTTATGCATACCTATCTGCTGTTCTTGAGGTGTAAAAGGAAAGGTGAAAATCGGGCCAGGCCAAGTA
CTCAGCTGTCTTAATAGGATGAAGCCTTAAGCAGTGGAAATTTCAGTTATTTTCCACAGTATTCCATTTTGGAGGATTTGGGGTGTTTAC
TTTTTAAATTCTTGAACAACTTAACCTCCATGAGGCTTTGTGAAGTCAGCTGTGACCACCCTCCTCTTACTGTGTTCTCAGTATTCATTC
ACTTCCAGGGAAGAATGACAGCCACAGGGAGATGGTGGTGGGCAAGAATGAGAGTCCCAGGATCCAGATTTAGCCTCAGATCTTCCCCAT
TCAGGAAGGGTTTTCCATTTAACAAGAGCACTAGTATGAAAACATTAGGGACAAATCTCCCATGTCTTTGAAATTCGGATTCTCCTCTTG
AGATCCCCTTCCTCACCTGCCAATCAACTTTATAAGGCCACAAGTGGTCACTGGTTTTCCTTCCACAGGTTTGAGGTTCTCAGCTTTCCT
TAAGCGACCCAGCAGCTCCGCTGTTTTCAGAGTGAATATGTTAAGCTTTGATGAGATTCTATTTTCAGTAAGTTAGTGCTTCTGGGACAC
TTGGAGAAAGCTGTGAGAGTCATTGTCTACGCAAAGAACAACGAAGCTGATCCTAAAAGTGATCCAATCTAAGAAAATGGTAAAACGAGC
TCTGGCCACAGCACAGAATTTTATGTGAGGAACTCAGATTTTTGAAGACTTAACAATTGCAGAGAAAGGTTGCAGCCTGCACACCATAGC
CCACCTCTCTGAGCAGACTTTGGTTTTGTGTGGTGACGTGGCACATGTTTGTACACTGGGATTTTTCAAAGGACGCTACGCGAGCAGACT
GACTTGCCTCTTCTGTGAGCACTGTGGCTTTTGTCAGATGGAGTGCCGGTCTGCAGAGGACTGCTCTTTCGAATCCACAGTGTTATCTGT
GTAAATAGCTTTAATTTTTCTTCTGTGTCTTAGGTGAAGTTTTGTTCATGTAGCAACCAGGTAGACAGTGACCAAATAAGGCTGTAAATG
TGCTGTAGTTTTCTACTGTGATGTACTTGAAGGAGAACCTGTGTCCTCTACTTTTCTGATCTCCCACAAGTATTTTGTGTTTGTTTCCTG
AGTCCTGAGGTTATTATTTTACTCCTGTTTTGCCCCCAGTTTTCTTTGTTTTTTTTCTGGAGACCCAGGGAGGCCCATGGTGGAGATCAT
TTGTAAGGAATGGATCATGGTCTGGGTTTCCAAAACTACCCTAGTACAGTGAATGAGAGAAATCTGCCTGGAAATTGTTTCAGAACCATG
TACCTTTATGCTTTGTGATTGTGAAACATTGACTTTTTTGTAACCCCAAAATGAAAACTGTTTAGTAAAGGGGATCTATTTTGTGTGTTT
TGAAACTTAGGTGCAATGTCCCCTGGAAAAAGCTAAAGAAATGTATATGTTCAATGACATTTTAAAATAAAATATTATATATATGTATAT

>52415_52415_1_MDM2-PPM1H_MDM2_chr12_69230529_ENST00000258148_PPM1H_chr12_63195940_ENST00000228705_length(amino acids)=628AA_BP=251
MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGD
LFGVPSFSVKEHRKIYTMIYRNLVVVNQQEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVS
EHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLAESEGVSCHYWSLFDGHAGS
GAAVVASRLLQHHITEQLQDIVDILKNSAVLPPTCLGEEPENTPANSRTLTRAASLRGGVGAPGSPSTPPTRFFTEKKIPHECLVIGALE
SAFKEMDLQIERERSSYNISGGCTALIVICLLGKLYVANAGDSRAIIIRNGEIIPMSSEFTPETERQRLQYLAFMQPHLLGNEFTHLEFP
RRVQRKELGKKMLYRDFNMTGWAYKTIEDEDLKFPLIYGEGKKARVMATIGVTRGLGDHDLKVHDSNIYIKPFLSSAPEVRIYDLSKYDH

--------------------------------------------------------------
>52415_52415_2_MDM2-PPM1H_MDM2_chr12_69230529_ENST00000258149_PPM1H_chr12_63195940_ENST00000228705_length(transcript)=6681nt_BP=1040nt
GCACCGCGGCGAGCTTGGCTGCTTCTGGGGCCTGTGTGGCCCTGTGTGTCGGAAAGATGGAGCAAGAAGCCGAGCCCGAGGGGCGGCCGC
GACCCCTCTGACCGAGATCCTGCTGCTTTCGCAGCCAGGAGCACCGTCCCTCCCCGGATTAGTGCGTACGAGCGCCCAGTGCCCTGGCCC
GGAGAGTGGAATGATCCCCGAGGCCCAGGGCGTCGTGCTTCCGCGCGCCCCGTGAAGGAAACTGGGGAGTCTTGAGGGACCCCCGACTCC
AAGCGCGAAAACCCCGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGA
TTCCAGCTTCGGAACAAGAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATA
CTATGAAAGAGGTTCTTTTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAA
ATGATCTTCTAGGAGATTTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAG
TAGTCAATCAGCAGGAAGAAAATTCAGATGAATTATCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTG
ATGAAAGCCTGGCTCTGTGTGTAATAAGGGAGATATGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGGATC
TTGATGCTGGTGTAAGTGAACATTCAGGTGATTGGTTGGATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAATTTGAAGTTGAATCTC
TCGACTCAGAAGATTATAGCCTTAGTGAAGAAGGACAAGAACTCTCAGATGAAGATGATGAGGTATATCAAGTTACTGTGTATCAGGCAG
GGGAGAGTGATACAGATTCATTTGAAGAAGATCCTGAAATTTCCTTAGCTGAATCCGAGGGTGTTTCCTGCCACTATTGGTCGCTGTTTG
ACGGGCACGCGGGGTCCGGGGCCGCGGTGGTGGCGTCACGCCTGCTGCAGCACCACATCACGGAGCAGCTGCAGGACATCGTGGACATCC
TGAAGAACTCCGCCGTCCTGCCCCCTACCTGCCTGGGGGAGGAGCCTGAGAACACGCCCGCCAACAGCCGGACTCTGACCCGGGCAGCCT
CCCTGCGCGGAGGGGTGGGGGCCCCGGGCTCCCCCAGCACGCCCCCCACACGCTTCTTTACCGAGAAGAAGATTCCCCATGAGTGCCTGG
TCATCGGAGCGCTTGAAAGTGCATTCAAGGAAATGGACCTACAGATAGAACGAGAGAGGAGTTCATATAATATATCTGGTGGCTGCACGG
CCCTCATTGTGATTTGCCTTTTGGGGAAGCTGTATGTTGCAAATGCTGGGGATAGCAGGGCCATAATCATCAGAAATGGAGAAATTATCC
CCATGTCTTCAGAATTTACCCCCGAGACGGAGCGCCAGCGACTTCAGTACCTGGCATTCATGCAGCCTCACTTGCTGGGAAATGAGTTCA
CACATTTGGAGTTTCCAAGGAGAGTACAGAGAAAGGAGCTTGGAAAGAAGATGCTCTACAGGGACTTTAATATGACAGGCTGGGCATACA
AAACCATTGAGGATGAGGACTTGAAGTTCCCCCTTATATATGGAGAAGGCAAGAAGGCCCGGGTAATGGCAACTATTGGAGTGACCAGGG
GACTTGGGGACCATGACCTGAAGGTGCATGACTCCAACATCTACATTAAACCATTCCTGTCTTCAGCTCCAGAGGTAAGAATCTACGATC
TTTCAAAATATGATCATGGATCAGATGATGTGCTGATCTTGGCCACTGATGGACTCTGGGACGTTTTATCAAATGAAGAAGTAGCAGAAG
CAATCACTCAGTTTCTTCCTAACTGTGATCCAGATGATCCTCACAGGTACACACTGGCAGCTCAGGACCTGGTGATGCGTGCCCGGGGTG
TGCTGAAGGACAGAGGATGGCGGATATCTAATGACCGACTGGGCTCAGGAGACGACATTTCTGTATATGTCATTCCTTTAATACATGGAA
ACAAGCTGTCATGAAAATGGCCCAGGGGATTGGGAGGACAGAGGGGAAGAAAGCTGGGATGCCTCTTGGCAGGACGGAACTGGGAAGTGC
CCCAGCTGAGTTCCAAGTGATGCAGTCTCTTCCCAGCCCAAGCGGGGAGTTCATGGCCAAAAGACTATGCTTCAAGATGACCCTTTGGTT
TCCATTTCTTCTTTAGTAACAGGTCAACTCAACAAGAGCAAAACACAAAGGCTGCTACCAAGTGTTGTTGTATTTCAGTTCCTTTCATAG
GCCTCCGAGGTGGCCATTGACTATTTGGGGTATATATGTCATATTTATTTTATCTAGAGTAGCTGGGGCAGCCATTTTCAGGTGTAAATG
GCAGAGGACTCTTCAGCCTGTCAAGCTGCCAGCTTATCTACGGGTTAAAAAGTGCTGCATTGGAAAGTAGGGGGTCATGCCTCAAAATGT
AAGTAAGTGCCCACCTTCTAGGAAGCCTGAGGTTTATTTCAGGGATTGCCGTCTGCCCCCCGCCCCCCTTCTCTTTTTTTCTTCTCTGTT
TCTATTCTTTTATGGCAGTGGTGGAGTGAGGCAGGGATTTTTTTTTTTTTTTTTCGTGTTTTTGACATTCCTTGAATCTGTTTTTTATTC
CCCTTCCACAGAACAGGCCTGGGACTTTCCAACACCCTGCTAAGGAAGTTCTGTGTCCAAGTCCCACCCAGGCTGGGTTGTCCCCACCTC
CTCCAGCCCACACAGCCCAGGCAGCATCCGGGCCAGTGCCCTGCATGACAGAGGGTCTTTGTTGTGTAATGTTTGTTCCCAAGTTGCATT
TTCTAACCGAATCAGTGTGTTTTCATGAAACTGAGTGTTTCTGTGGACCAGTAGTTCCTCTGTTGTCTTCAGTGGTCTTCCTGTGTGGCT
CAAGGGTTCTCTGTGAGAGTCTGGATTTTCATTTCTGGAATGGCTGGCCCCATCCCACTTTTCTGTATCATGGGGACACATATAAAGCAG
TGTTTAATAGAGCAGTTTAAGAAGTTGCTTGCATCTGTTGGTTCACCATGGCTCATCTGGGGACCATTTTGGATTCATGTTTCATGGCTT
GTGACTGTCCCCAAGCCCACTCCAAACAAAGTGTAAGGATCAGAGTTCTGTCAAGGAGCAGCAGTTCTGCTCTCCCCATCATCTTTGTGC
AAGGCCCCTCGGGGGGCACTTTAATAAAAGAATTTGAAATGGGTTGACTGGCCATTCTCATGCTGTGCTCCCTGTCTCTTCTCTTCTCTA
AAGAATCATGTCCCAGCTCCTCAAGGTCCCTCTATGGTTCCACATCTGAGTGTTCGCCACAAGAGCAGCAGCAGCAGGCACAGTGCATGC
CATATCTACCTGCTGCTTCTCTGCTGGGAGGAATGGCCAAGTAGATTATAAAACTCACTTCTGTCTCTTAGGCAGACTTGTACGGCCACA
AAATTACCTAGTCTTCTTCCTGCTGAGCTACTGAGGTATTGCCACCATTTTGACAACTTTGAGTAATTAAAACACTCTTCTGACCCAAAA
AGGAAAAAAGGTCACTGACGTGACCCCCCCAGCATGCTAGAGAGCTAATTCCAGTTCTCATATTTGTTTGAATTTCTTCCCAGAGGAGAG
GATAGGAACCTCTCCTCCAGGGCAGTAAATCACCTGCATTTCTGGAGTTGTCGGTATTGTATTCGAAAAGGCCTGGAGCCCCTCCTGCTC
AGGAAAGAACTCATTCCAGGGTGTGGAGACAGTGCCGTCTGGCAGGTGAAATACTGTGGGAATTCACGCCACCAGGTGTTTGTGCAAGTG
TTGGCCTGGGAAGAATGGGACTTCGGCCTTGTCAGGAGTTGTCTTCATCTGCAGCACGTTTCTTCCTCCTGCAGTAGATCTTAGCTACCC
CAGATATCTCTATGGAGAGAAGTTTGTGGAAAATGCTTTGCTTCGTGGCAGAGTCTGATGCTGTAGGAAAACCTTCGGGCATGTGACAGC
AGTGTGGTCCACTCCCTGTTCTGCCCTGGCACTCAGAGTCATGTGTAAGTAGGAAACCTGAGCAAGTCTTCCGTGGAGGACCCTGAGCTG
CCGTCTTTGGGATCCTTCCTGTGTCCCCACCGTCTTTCATTTATTTGCTTTCCTGGGCCTCTATCTGGGCCCTACCTTGAGCTTCTCCAG
TTTTATTCAAGCCACCAGAGTAAGAATTTGGGTGTAGATGTCACAACTACCTTCTACTCAATTCACCAATTCATTTACTGCTATGGCACG
TCTCAGGAATAACTCTAGAAACCTCTAAATCGAAATATTATAAAATCTTGAGCACTTAGTCCTGCTGGTTTTAGTTAGAAAGGCATCCAG
GAATTGTTTTCCTACGCCCCCTTGAGTGGAAAGATCTTAGTTAGAAGATAAAGTCAAGTTTGTGTTCAGGGGATGGGAGGAAGACTATAA
ATAAGATGAAGAAATCAAAAGTAGGAAACATGATGTAAACGAAGCATGGCAGATCTGTCCAGCACTGATATTGCTCTATAAATTGAGCTT
ACTCAGTTTTGGCCTTATTTTTTTACCCAGGCCCCATGTCACCCAGTCCTAAAACAGTAACCGTGTCTACATAACGGGTTGGCCCCTGGT
GCATCCCTGGAAAAGTCAAAGGACGCACACTTCGAAATTCTGCAGAACGTATTTATACATGGTTCAGAAATCTTGCGTATCTGACTTATA
GCCAAATCTGCTTGCTCGAATAGCCTCAGAGGAAGTCTTGTTTAATAAAAACCTTTTGATTTCCTAGTCAAGTCTTTATGGTTGTCTCGA
GGGGTGTGTGGCTACTTTAATGAAAGGCTTTCCTGCTCTAAATCTCTTTGCTGGGCTGGGCCTCTTCAGACTATCTGGTGAAACTCCTTT
CCTTAGAACAAACTCAGTCCGTCCATGCTCTGTGGCATTTTGCTAGATGATAACCAAAGCCTTATTCCTGTAGCCAGTGTCAGCAGTCAG
AGAGGTGGAGGGTGTGTTCTGCTGTGGTTATGCATACCTATCTGCTGTTCTTGAGGTGTAAAAGGAAAGGTGAAAATCGGGCCAGGCCAA
GTACTCAGCTGTCTTAATAGGATGAAGCCTTAAGCAGTGGAAATTTCAGTTATTTTCCACAGTATTCCATTTTGGAGGATTTGGGGTGTT
TACTTTTTAAATTCTTGAACAACTTAACCTCCATGAGGCTTTGTGAAGTCAGCTGTGACCACCCTCCTCTTACTGTGTTCTCAGTATTCA
TTCACTTCCAGGGAAGAATGACAGCCACAGGGAGATGGTGGTGGGCAAGAATGAGAGTCCCAGGATCCAGATTTAGCCTCAGATCTTCCC
CATTCAGGAAGGGTTTTCCATTTAACAAGAGCACTAGTATGAAAACATTAGGGACAAATCTCCCATGTCTTTGAAATTCGGATTCTCCTC
TTGAGATCCCCTTCCTCACCTGCCAATCAACTTTATAAGGCCACAAGTGGTCACTGGTTTTCCTTCCACAGGTTTGAGGTTCTCAGCTTT
CCTTAAGCGACCCAGCAGCTCCGCTGTTTTCAGAGTGAATATGTTAAGCTTTGATGAGATTCTATTTTCAGTAAGTTAGTGCTTCTGGGA
CACTTGGAGAAAGCTGTGAGAGTCATTGTCTACGCAAAGAACAACGAAGCTGATCCTAAAAGTGATCCAATCTAAGAAAATGGTAAAACG
AGCTCTGGCCACAGCACAGAATTTTATGTGAGGAACTCAGATTTTTGAAGACTTAACAATTGCAGAGAAAGGTTGCAGCCTGCACACCAT
AGCCCACCTCTCTGAGCAGACTTTGGTTTTGTGTGGTGACGTGGCACATGTTTGTACACTGGGATTTTTCAAAGGACGCTACGCGAGCAG
ACTGACTTGCCTCTTCTGTGAGCACTGTGGCTTTTGTCAGATGGAGTGCCGGTCTGCAGAGGACTGCTCTTTCGAATCCACAGTGTTATC
TGTGTAAATAGCTTTAATTTTTCTTCTGTGTCTTAGGTGAAGTTTTGTTCATGTAGCAACCAGGTAGACAGTGACCAAATAAGGCTGTAA
ATGTGCTGTAGTTTTCTACTGTGATGTACTTGAAGGAGAACCTGTGTCCTCTACTTTTCTGATCTCCCACAAGTATTTTGTGTTTGTTTC
CTGAGTCCTGAGGTTATTATTTTACTCCTGTTTTGCCCCCAGTTTTCTTTGTTTTTTTTCTGGAGACCCAGGGAGGCCCATGGTGGAGAT
CATTTGTAAGGAATGGATCATGGTCTGGGTTTCCAAAACTACCCTAGTACAGTGAATGAGAGAAATCTGCCTGGAAATTGTTTCAGAACC
ATGTACCTTTATGCTTTGTGATTGTGAAACATTGACTTTTTTGTAACCCCAAAATGAAAACTGTTTAGTAAAGGGGATCTATTTTGTGTG
TTTTGAAACTTAGGTGCAATGTCCCCTGGAAAAAGCTAAAGAAATGTATATGTTCAATGACATTTTAAAATAAAATATTATATATATGTA

>52415_52415_2_MDM2-PPM1H_MDM2_chr12_69230529_ENST00000258149_PPM1H_chr12_63195940_ENST00000228705_length(amino acids)=640AA_BP=263
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQ
HIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTG
TPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLAESEGVSC
HYWSLFDGHAGSGAAVVASRLLQHHITEQLQDIVDILKNSAVLPPTCLGEEPENTPANSRTLTRAASLRGGVGAPGSPSTPPTRFFTEKK
IPHECLVIGALESAFKEMDLQIERERSSYNISGGCTALIVICLLGKLYVANAGDSRAIIIRNGEIIPMSSEFTPETERQRLQYLAFMQPH
LLGNEFTHLEFPRRVQRKELGKKMLYRDFNMTGWAYKTIEDEDLKFPLIYGEGKKARVMATIGVTRGLGDHDLKVHDSNIYIKPFLSSAP
EVRIYDLSKYDHGSDDVLILATDGLWDVLSNEEVAEAITQFLPNCDPDDPHRYTLAAQDLVMRARGVLKDRGWRISNDRLGSGDDISVYV

--------------------------------------------------------------
>52415_52415_3_MDM2-PPM1H_MDM2_chr12_69230529_ENST00000299252_PPM1H_chr12_63195940_ENST00000228705_length(transcript)=6031nt_BP=390nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTAGACCA
AAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATACTATGAAAGAGGATCTTGATGCTGGTGTAAGTGAA
CATTCAGGTGATTGGTTGGATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAATTTGAAGTTGAATCTCTCGACTCAGAAGATTATAGC
CTTAGTGAAGAAGGACAAGAACTCTCAGATGAAGATGATGAGGTATATCAAGTTACTGTGTATCAGGCAGGGGAGAGTGATACAGATTCA
TTTGAAGAAGATCCTGAAATTTCCTTAGCTGAATCCGAGGGTGTTTCCTGCCACTATTGGTCGCTGTTTGACGGGCACGCGGGGTCCGGG
GCCGCGGTGGTGGCGTCACGCCTGCTGCAGCACCACATCACGGAGCAGCTGCAGGACATCGTGGACATCCTGAAGAACTCCGCCGTCCTG
CCCCCTACCTGCCTGGGGGAGGAGCCTGAGAACACGCCCGCCAACAGCCGGACTCTGACCCGGGCAGCCTCCCTGCGCGGAGGGGTGGGG
GCCCCGGGCTCCCCCAGCACGCCCCCCACACGCTTCTTTACCGAGAAGAAGATTCCCCATGAGTGCCTGGTCATCGGAGCGCTTGAAAGT
GCATTCAAGGAAATGGACCTACAGATAGAACGAGAGAGGAGTTCATATAATATATCTGGTGGCTGCACGGCCCTCATTGTGATTTGCCTT
TTGGGGAAGCTGTATGTTGCAAATGCTGGGGATAGCAGGGCCATAATCATCAGAAATGGAGAAATTATCCCCATGTCTTCAGAATTTACC
CCCGAGACGGAGCGCCAGCGACTTCAGTACCTGGCATTCATGCAGCCTCACTTGCTGGGAAATGAGTTCACACATTTGGAGTTTCCAAGG
AGAGTACAGAGAAAGGAGCTTGGAAAGAAGATGCTCTACAGGGACTTTAATATGACAGGCTGGGCATACAAAACCATTGAGGATGAGGAC
TTGAAGTTCCCCCTTATATATGGAGAAGGCAAGAAGGCCCGGGTAATGGCAACTATTGGAGTGACCAGGGGACTTGGGGACCATGACCTG
AAGGTGCATGACTCCAACATCTACATTAAACCATTCCTGTCTTCAGCTCCAGAGGTAAGAATCTACGATCTTTCAAAATATGATCATGGA
TCAGATGATGTGCTGATCTTGGCCACTGATGGACTCTGGGACGTTTTATCAAATGAAGAAGTAGCAGAAGCAATCACTCAGTTTCTTCCT
AACTGTGATCCAGATGATCCTCACAGGTACACACTGGCAGCTCAGGACCTGGTGATGCGTGCCCGGGGTGTGCTGAAGGACAGAGGATGG
CGGATATCTAATGACCGACTGGGCTCAGGAGACGACATTTCTGTATATGTCATTCCTTTAATACATGGAAACAAGCTGTCATGAAAATGG
CCCAGGGGATTGGGAGGACAGAGGGGAAGAAAGCTGGGATGCCTCTTGGCAGGACGGAACTGGGAAGTGCCCCAGCTGAGTTCCAAGTGA
TGCAGTCTCTTCCCAGCCCAAGCGGGGAGTTCATGGCCAAAAGACTATGCTTCAAGATGACCCTTTGGTTTCCATTTCTTCTTTAGTAAC
AGGTCAACTCAACAAGAGCAAAACACAAAGGCTGCTACCAAGTGTTGTTGTATTTCAGTTCCTTTCATAGGCCTCCGAGGTGGCCATTGA
CTATTTGGGGTATATATGTCATATTTATTTTATCTAGAGTAGCTGGGGCAGCCATTTTCAGGTGTAAATGGCAGAGGACTCTTCAGCCTG
TCAAGCTGCCAGCTTATCTACGGGTTAAAAAGTGCTGCATTGGAAAGTAGGGGGTCATGCCTCAAAATGTAAGTAAGTGCCCACCTTCTA
GGAAGCCTGAGGTTTATTTCAGGGATTGCCGTCTGCCCCCCGCCCCCCTTCTCTTTTTTTCTTCTCTGTTTCTATTCTTTTATGGCAGTG
GTGGAGTGAGGCAGGGATTTTTTTTTTTTTTTTTCGTGTTTTTGACATTCCTTGAATCTGTTTTTTATTCCCCTTCCACAGAACAGGCCT
GGGACTTTCCAACACCCTGCTAAGGAAGTTCTGTGTCCAAGTCCCACCCAGGCTGGGTTGTCCCCACCTCCTCCAGCCCACACAGCCCAG
GCAGCATCCGGGCCAGTGCCCTGCATGACAGAGGGTCTTTGTTGTGTAATGTTTGTTCCCAAGTTGCATTTTCTAACCGAATCAGTGTGT
TTTCATGAAACTGAGTGTTTCTGTGGACCAGTAGTTCCTCTGTTGTCTTCAGTGGTCTTCCTGTGTGGCTCAAGGGTTCTCTGTGAGAGT
CTGGATTTTCATTTCTGGAATGGCTGGCCCCATCCCACTTTTCTGTATCATGGGGACACATATAAAGCAGTGTTTAATAGAGCAGTTTAA
GAAGTTGCTTGCATCTGTTGGTTCACCATGGCTCATCTGGGGACCATTTTGGATTCATGTTTCATGGCTTGTGACTGTCCCCAAGCCCAC
TCCAAACAAAGTGTAAGGATCAGAGTTCTGTCAAGGAGCAGCAGTTCTGCTCTCCCCATCATCTTTGTGCAAGGCCCCTCGGGGGGCACT
TTAATAAAAGAATTTGAAATGGGTTGACTGGCCATTCTCATGCTGTGCTCCCTGTCTCTTCTCTTCTCTAAAGAATCATGTCCCAGCTCC
TCAAGGTCCCTCTATGGTTCCACATCTGAGTGTTCGCCACAAGAGCAGCAGCAGCAGGCACAGTGCATGCCATATCTACCTGCTGCTTCT
CTGCTGGGAGGAATGGCCAAGTAGATTATAAAACTCACTTCTGTCTCTTAGGCAGACTTGTACGGCCACAAAATTACCTAGTCTTCTTCC
TGCTGAGCTACTGAGGTATTGCCACCATTTTGACAACTTTGAGTAATTAAAACACTCTTCTGACCCAAAAAGGAAAAAAGGTCACTGACG
TGACCCCCCCAGCATGCTAGAGAGCTAATTCCAGTTCTCATATTTGTTTGAATTTCTTCCCAGAGGAGAGGATAGGAACCTCTCCTCCAG
GGCAGTAAATCACCTGCATTTCTGGAGTTGTCGGTATTGTATTCGAAAAGGCCTGGAGCCCCTCCTGCTCAGGAAAGAACTCATTCCAGG
GTGTGGAGACAGTGCCGTCTGGCAGGTGAAATACTGTGGGAATTCACGCCACCAGGTGTTTGTGCAAGTGTTGGCCTGGGAAGAATGGGA
CTTCGGCCTTGTCAGGAGTTGTCTTCATCTGCAGCACGTTTCTTCCTCCTGCAGTAGATCTTAGCTACCCCAGATATCTCTATGGAGAGA
AGTTTGTGGAAAATGCTTTGCTTCGTGGCAGAGTCTGATGCTGTAGGAAAACCTTCGGGCATGTGACAGCAGTGTGGTCCACTCCCTGTT
CTGCCCTGGCACTCAGAGTCATGTGTAAGTAGGAAACCTGAGCAAGTCTTCCGTGGAGGACCCTGAGCTGCCGTCTTTGGGATCCTTCCT
GTGTCCCCACCGTCTTTCATTTATTTGCTTTCCTGGGCCTCTATCTGGGCCCTACCTTGAGCTTCTCCAGTTTTATTCAAGCCACCAGAG
TAAGAATTTGGGTGTAGATGTCACAACTACCTTCTACTCAATTCACCAATTCATTTACTGCTATGGCACGTCTCAGGAATAACTCTAGAA
ACCTCTAAATCGAAATATTATAAAATCTTGAGCACTTAGTCCTGCTGGTTTTAGTTAGAAAGGCATCCAGGAATTGTTTTCCTACGCCCC
CTTGAGTGGAAAGATCTTAGTTAGAAGATAAAGTCAAGTTTGTGTTCAGGGGATGGGAGGAAGACTATAAATAAGATGAAGAAATCAAAA
GTAGGAAACATGATGTAAACGAAGCATGGCAGATCTGTCCAGCACTGATATTGCTCTATAAATTGAGCTTACTCAGTTTTGGCCTTATTT
TTTTACCCAGGCCCCATGTCACCCAGTCCTAAAACAGTAACCGTGTCTACATAACGGGTTGGCCCCTGGTGCATCCCTGGAAAAGTCAAA
GGACGCACACTTCGAAATTCTGCAGAACGTATTTATACATGGTTCAGAAATCTTGCGTATCTGACTTATAGCCAAATCTGCTTGCTCGAA
TAGCCTCAGAGGAAGTCTTGTTTAATAAAAACCTTTTGATTTCCTAGTCAAGTCTTTATGGTTGTCTCGAGGGGTGTGTGGCTACTTTAA
TGAAAGGCTTTCCTGCTCTAAATCTCTTTGCTGGGCTGGGCCTCTTCAGACTATCTGGTGAAACTCCTTTCCTTAGAACAAACTCAGTCC
GTCCATGCTCTGTGGCATTTTGCTAGATGATAACCAAAGCCTTATTCCTGTAGCCAGTGTCAGCAGTCAGAGAGGTGGAGGGTGTGTTCT
GCTGTGGTTATGCATACCTATCTGCTGTTCTTGAGGTGTAAAAGGAAAGGTGAAAATCGGGCCAGGCCAAGTACTCAGCTGTCTTAATAG
GATGAAGCCTTAAGCAGTGGAAATTTCAGTTATTTTCCACAGTATTCCATTTTGGAGGATTTGGGGTGTTTACTTTTTAAATTCTTGAAC
AACTTAACCTCCATGAGGCTTTGTGAAGTCAGCTGTGACCACCCTCCTCTTACTGTGTTCTCAGTATTCATTCACTTCCAGGGAAGAATG
ACAGCCACAGGGAGATGGTGGTGGGCAAGAATGAGAGTCCCAGGATCCAGATTTAGCCTCAGATCTTCCCCATTCAGGAAGGGTTTTCCA
TTTAACAAGAGCACTAGTATGAAAACATTAGGGACAAATCTCCCATGTCTTTGAAATTCGGATTCTCCTCTTGAGATCCCCTTCCTCACC
TGCCAATCAACTTTATAAGGCCACAAGTGGTCACTGGTTTTCCTTCCACAGGTTTGAGGTTCTCAGCTTTCCTTAAGCGACCCAGCAGCT
CCGCTGTTTTCAGAGTGAATATGTTAAGCTTTGATGAGATTCTATTTTCAGTAAGTTAGTGCTTCTGGGACACTTGGAGAAAGCTGTGAG
AGTCATTGTCTACGCAAAGAACAACGAAGCTGATCCTAAAAGTGATCCAATCTAAGAAAATGGTAAAACGAGCTCTGGCCACAGCACAGA
ATTTTATGTGAGGAACTCAGATTTTTGAAGACTTAACAATTGCAGAGAAAGGTTGCAGCCTGCACACCATAGCCCACCTCTCTGAGCAGA
CTTTGGTTTTGTGTGGTGACGTGGCACATGTTTGTACACTGGGATTTTTCAAAGGACGCTACGCGAGCAGACTGACTTGCCTCTTCTGTG
AGCACTGTGGCTTTTGTCAGATGGAGTGCCGGTCTGCAGAGGACTGCTCTTTCGAATCCACAGTGTTATCTGTGTAAATAGCTTTAATTT
TTCTTCTGTGTCTTAGGTGAAGTTTTGTTCATGTAGCAACCAGGTAGACAGTGACCAAATAAGGCTGTAAATGTGCTGTAGTTTTCTACT
GTGATGTACTTGAAGGAGAACCTGTGTCCTCTACTTTTCTGATCTCCCACAAGTATTTTGTGTTTGTTTCCTGAGTCCTGAGGTTATTAT
TTTACTCCTGTTTTGCCCCCAGTTTTCTTTGTTTTTTTTCTGGAGACCCAGGGAGGCCCATGGTGGAGATCATTTGTAAGGAATGGATCA
TGGTCTGGGTTTCCAAAACTACCCTAGTACAGTGAATGAGAGAAATCTGCCTGGAAATTGTTTCAGAACCATGTACCTTTATGCTTTGTG
ATTGTGAAACATTGACTTTTTTGTAACCCCAAAATGAAAACTGTTTAGTAAAGGGGATCTATTTTGTGTGTTTTGAAACTTAGGTGCAAT
GTCCCCTGGAAAAAGCTAAAGAAATGTATATGTTCAATGACATTTTAAAATAAAATATTATATATATGTATATACGACATATTCAGCAAA

>52415_52415_3_MDM2-PPM1H_MDM2_chr12_69230529_ENST00000299252_PPM1H_chr12_63195940_ENST00000228705_length(amino acids)=507AA_BP=130
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYS
LSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLAESEGVSCHYWSLFDGHAGSGAAVVASRLLQHHITEQLQDIVDILKNSAVL
PPTCLGEEPENTPANSRTLTRAASLRGGVGAPGSPSTPPTRFFTEKKIPHECLVIGALESAFKEMDLQIERERSSYNISGGCTALIVICL
LGKLYVANAGDSRAIIIRNGEIIPMSSEFTPETERQRLQYLAFMQPHLLGNEFTHLEFPRRVQRKELGKKMLYRDFNMTGWAYKTIEDED
LKFPLIYGEGKKARVMATIGVTRGLGDHDLKVHDSNIYIKPFLSSAPEVRIYDLSKYDHGSDDVLILATDGLWDVLSNEEVAEAITQFLP

--------------------------------------------------------------
>52415_52415_4_MDM2-PPM1H_MDM2_chr12_69230529_ENST00000350057_PPM1H_chr12_63195940_ENST00000228705_length(transcript)=6466nt_BP=825nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTCTTTTT
TATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATGATCTTCTAGGAGATTTG
TTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAGTCAATCAGCAGGAATCA
TCGGACTCAGGTACATCTGTGAGTGAGAACAGGTGTCACCTTGAAGGTGGGAGTGATCAAAAGGACCTTGTACAAGAGCTTCAGGAAGAG
AAACCTTCATCTTCACATTTGGTTTCTAGACCATCTACCTCATCTAGAAGGAGAGCAATTAGTGAGACAGAAGAAAATTCAGATGAATTA
TCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTGATGAAAGCCTGGCTCTGTGTGTAATAAGGGAGATA
TGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGGATCTTGATGCTGGTGTAAGTGAACATTCAGGTGATTGG
TTGGATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAATTTGAAGTTGAATCTCTCGACTCAGAAGATTATAGCCTTAGTGAAGAAGGA
CAAGAACTCTCAGATGAAGATGATGAGGTATATCAAGTTACTGTGTATCAGGCAGGGGAGAGTGATACAGATTCATTTGAAGAAGATCCT
GAAATTTCCTTAGCTGAATCCGAGGGTGTTTCCTGCCACTATTGGTCGCTGTTTGACGGGCACGCGGGGTCCGGGGCCGCGGTGGTGGCG
TCACGCCTGCTGCAGCACCACATCACGGAGCAGCTGCAGGACATCGTGGACATCCTGAAGAACTCCGCCGTCCTGCCCCCTACCTGCCTG
GGGGAGGAGCCTGAGAACACGCCCGCCAACAGCCGGACTCTGACCCGGGCAGCCTCCCTGCGCGGAGGGGTGGGGGCCCCGGGCTCCCCC
AGCACGCCCCCCACACGCTTCTTTACCGAGAAGAAGATTCCCCATGAGTGCCTGGTCATCGGAGCGCTTGAAAGTGCATTCAAGGAAATG
GACCTACAGATAGAACGAGAGAGGAGTTCATATAATATATCTGGTGGCTGCACGGCCCTCATTGTGATTTGCCTTTTGGGGAAGCTGTAT
GTTGCAAATGCTGGGGATAGCAGGGCCATAATCATCAGAAATGGAGAAATTATCCCCATGTCTTCAGAATTTACCCCCGAGACGGAGCGC
CAGCGACTTCAGTACCTGGCATTCATGCAGCCTCACTTGCTGGGAAATGAGTTCACACATTTGGAGTTTCCAAGGAGAGTACAGAGAAAG
GAGCTTGGAAAGAAGATGCTCTACAGGGACTTTAATATGACAGGCTGGGCATACAAAACCATTGAGGATGAGGACTTGAAGTTCCCCCTT
ATATATGGAGAAGGCAAGAAGGCCCGGGTAATGGCAACTATTGGAGTGACCAGGGGACTTGGGGACCATGACCTGAAGGTGCATGACTCC
AACATCTACATTAAACCATTCCTGTCTTCAGCTCCAGAGGTAAGAATCTACGATCTTTCAAAATATGATCATGGATCAGATGATGTGCTG
ATCTTGGCCACTGATGGACTCTGGGACGTTTTATCAAATGAAGAAGTAGCAGAAGCAATCACTCAGTTTCTTCCTAACTGTGATCCAGAT
GATCCTCACAGGTACACACTGGCAGCTCAGGACCTGGTGATGCGTGCCCGGGGTGTGCTGAAGGACAGAGGATGGCGGATATCTAATGAC
CGACTGGGCTCAGGAGACGACATTTCTGTATATGTCATTCCTTTAATACATGGAAACAAGCTGTCATGAAAATGGCCCAGGGGATTGGGA
GGACAGAGGGGAAGAAAGCTGGGATGCCTCTTGGCAGGACGGAACTGGGAAGTGCCCCAGCTGAGTTCCAAGTGATGCAGTCTCTTCCCA
GCCCAAGCGGGGAGTTCATGGCCAAAAGACTATGCTTCAAGATGACCCTTTGGTTTCCATTTCTTCTTTAGTAACAGGTCAACTCAACAA
GAGCAAAACACAAAGGCTGCTACCAAGTGTTGTTGTATTTCAGTTCCTTTCATAGGCCTCCGAGGTGGCCATTGACTATTTGGGGTATAT
ATGTCATATTTATTTTATCTAGAGTAGCTGGGGCAGCCATTTTCAGGTGTAAATGGCAGAGGACTCTTCAGCCTGTCAAGCTGCCAGCTT
ATCTACGGGTTAAAAAGTGCTGCATTGGAAAGTAGGGGGTCATGCCTCAAAATGTAAGTAAGTGCCCACCTTCTAGGAAGCCTGAGGTTT
ATTTCAGGGATTGCCGTCTGCCCCCCGCCCCCCTTCTCTTTTTTTCTTCTCTGTTTCTATTCTTTTATGGCAGTGGTGGAGTGAGGCAGG
GATTTTTTTTTTTTTTTTTCGTGTTTTTGACATTCCTTGAATCTGTTTTTTATTCCCCTTCCACAGAACAGGCCTGGGACTTTCCAACAC
CCTGCTAAGGAAGTTCTGTGTCCAAGTCCCACCCAGGCTGGGTTGTCCCCACCTCCTCCAGCCCACACAGCCCAGGCAGCATCCGGGCCA
GTGCCCTGCATGACAGAGGGTCTTTGTTGTGTAATGTTTGTTCCCAAGTTGCATTTTCTAACCGAATCAGTGTGTTTTCATGAAACTGAG
TGTTTCTGTGGACCAGTAGTTCCTCTGTTGTCTTCAGTGGTCTTCCTGTGTGGCTCAAGGGTTCTCTGTGAGAGTCTGGATTTTCATTTC
TGGAATGGCTGGCCCCATCCCACTTTTCTGTATCATGGGGACACATATAAAGCAGTGTTTAATAGAGCAGTTTAAGAAGTTGCTTGCATC
TGTTGGTTCACCATGGCTCATCTGGGGACCATTTTGGATTCATGTTTCATGGCTTGTGACTGTCCCCAAGCCCACTCCAAACAAAGTGTA
AGGATCAGAGTTCTGTCAAGGAGCAGCAGTTCTGCTCTCCCCATCATCTTTGTGCAAGGCCCCTCGGGGGGCACTTTAATAAAAGAATTT
GAAATGGGTTGACTGGCCATTCTCATGCTGTGCTCCCTGTCTCTTCTCTTCTCTAAAGAATCATGTCCCAGCTCCTCAAGGTCCCTCTAT
GGTTCCACATCTGAGTGTTCGCCACAAGAGCAGCAGCAGCAGGCACAGTGCATGCCATATCTACCTGCTGCTTCTCTGCTGGGAGGAATG
GCCAAGTAGATTATAAAACTCACTTCTGTCTCTTAGGCAGACTTGTACGGCCACAAAATTACCTAGTCTTCTTCCTGCTGAGCTACTGAG
GTATTGCCACCATTTTGACAACTTTGAGTAATTAAAACACTCTTCTGACCCAAAAAGGAAAAAAGGTCACTGACGTGACCCCCCCAGCAT
GCTAGAGAGCTAATTCCAGTTCTCATATTTGTTTGAATTTCTTCCCAGAGGAGAGGATAGGAACCTCTCCTCCAGGGCAGTAAATCACCT
GCATTTCTGGAGTTGTCGGTATTGTATTCGAAAAGGCCTGGAGCCCCTCCTGCTCAGGAAAGAACTCATTCCAGGGTGTGGAGACAGTGC
CGTCTGGCAGGTGAAATACTGTGGGAATTCACGCCACCAGGTGTTTGTGCAAGTGTTGGCCTGGGAAGAATGGGACTTCGGCCTTGTCAG
GAGTTGTCTTCATCTGCAGCACGTTTCTTCCTCCTGCAGTAGATCTTAGCTACCCCAGATATCTCTATGGAGAGAAGTTTGTGGAAAATG
CTTTGCTTCGTGGCAGAGTCTGATGCTGTAGGAAAACCTTCGGGCATGTGACAGCAGTGTGGTCCACTCCCTGTTCTGCCCTGGCACTCA
GAGTCATGTGTAAGTAGGAAACCTGAGCAAGTCTTCCGTGGAGGACCCTGAGCTGCCGTCTTTGGGATCCTTCCTGTGTCCCCACCGTCT
TTCATTTATTTGCTTTCCTGGGCCTCTATCTGGGCCCTACCTTGAGCTTCTCCAGTTTTATTCAAGCCACCAGAGTAAGAATTTGGGTGT
AGATGTCACAACTACCTTCTACTCAATTCACCAATTCATTTACTGCTATGGCACGTCTCAGGAATAACTCTAGAAACCTCTAAATCGAAA
TATTATAAAATCTTGAGCACTTAGTCCTGCTGGTTTTAGTTAGAAAGGCATCCAGGAATTGTTTTCCTACGCCCCCTTGAGTGGAAAGAT
CTTAGTTAGAAGATAAAGTCAAGTTTGTGTTCAGGGGATGGGAGGAAGACTATAAATAAGATGAAGAAATCAAAAGTAGGAAACATGATG
TAAACGAAGCATGGCAGATCTGTCCAGCACTGATATTGCTCTATAAATTGAGCTTACTCAGTTTTGGCCTTATTTTTTTACCCAGGCCCC
ATGTCACCCAGTCCTAAAACAGTAACCGTGTCTACATAACGGGTTGGCCCCTGGTGCATCCCTGGAAAAGTCAAAGGACGCACACTTCGA
AATTCTGCAGAACGTATTTATACATGGTTCAGAAATCTTGCGTATCTGACTTATAGCCAAATCTGCTTGCTCGAATAGCCTCAGAGGAAG
TCTTGTTTAATAAAAACCTTTTGATTTCCTAGTCAAGTCTTTATGGTTGTCTCGAGGGGTGTGTGGCTACTTTAATGAAAGGCTTTCCTG
CTCTAAATCTCTTTGCTGGGCTGGGCCTCTTCAGACTATCTGGTGAAACTCCTTTCCTTAGAACAAACTCAGTCCGTCCATGCTCTGTGG
CATTTTGCTAGATGATAACCAAAGCCTTATTCCTGTAGCCAGTGTCAGCAGTCAGAGAGGTGGAGGGTGTGTTCTGCTGTGGTTATGCAT
ACCTATCTGCTGTTCTTGAGGTGTAAAAGGAAAGGTGAAAATCGGGCCAGGCCAAGTACTCAGCTGTCTTAATAGGATGAAGCCTTAAGC
AGTGGAAATTTCAGTTATTTTCCACAGTATTCCATTTTGGAGGATTTGGGGTGTTTACTTTTTAAATTCTTGAACAACTTAACCTCCATG
AGGCTTTGTGAAGTCAGCTGTGACCACCCTCCTCTTACTGTGTTCTCAGTATTCATTCACTTCCAGGGAAGAATGACAGCCACAGGGAGA
TGGTGGTGGGCAAGAATGAGAGTCCCAGGATCCAGATTTAGCCTCAGATCTTCCCCATTCAGGAAGGGTTTTCCATTTAACAAGAGCACT
AGTATGAAAACATTAGGGACAAATCTCCCATGTCTTTGAAATTCGGATTCTCCTCTTGAGATCCCCTTCCTCACCTGCCAATCAACTTTA
TAAGGCCACAAGTGGTCACTGGTTTTCCTTCCACAGGTTTGAGGTTCTCAGCTTTCCTTAAGCGACCCAGCAGCTCCGCTGTTTTCAGAG
TGAATATGTTAAGCTTTGATGAGATTCTATTTTCAGTAAGTTAGTGCTTCTGGGACACTTGGAGAAAGCTGTGAGAGTCATTGTCTACGC
AAAGAACAACGAAGCTGATCCTAAAAGTGATCCAATCTAAGAAAATGGTAAAACGAGCTCTGGCCACAGCACAGAATTTTATGTGAGGAA
CTCAGATTTTTGAAGACTTAACAATTGCAGAGAAAGGTTGCAGCCTGCACACCATAGCCCACCTCTCTGAGCAGACTTTGGTTTTGTGTG
GTGACGTGGCACATGTTTGTACACTGGGATTTTTCAAAGGACGCTACGCGAGCAGACTGACTTGCCTCTTCTGTGAGCACTGTGGCTTTT
GTCAGATGGAGTGCCGGTCTGCAGAGGACTGCTCTTTCGAATCCACAGTGTTATCTGTGTAAATAGCTTTAATTTTTCTTCTGTGTCTTA
GGTGAAGTTTTGTTCATGTAGCAACCAGGTAGACAGTGACCAAATAAGGCTGTAAATGTGCTGTAGTTTTCTACTGTGATGTACTTGAAG
GAGAACCTGTGTCCTCTACTTTTCTGATCTCCCACAAGTATTTTGTGTTTGTTTCCTGAGTCCTGAGGTTATTATTTTACTCCTGTTTTG
CCCCCAGTTTTCTTTGTTTTTTTTCTGGAGACCCAGGGAGGCCCATGGTGGAGATCATTTGTAAGGAATGGATCATGGTCTGGGTTTCCA
AAACTACCCTAGTACAGTGAATGAGAGAAATCTGCCTGGAAATTGTTTCAGAACCATGTACCTTTATGCTTTGTGATTGTGAAACATTGA
CTTTTTTGTAACCCCAAAATGAAAACTGTTTAGTAAAGGGGATCTATTTTGTGTGTTTTGAAACTTAGGTGCAATGTCCCCTGGAAAAAG

>52415_52415_4_MDM2-PPM1H_MDM2_chr12_69230529_ENST00000350057_PPM1H_chr12_63195940_ENST00000228705_length(amino acids)=652AA_BP=275
MCNTNMSVPTDGAVTTSQIPASEQETLVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQES
SDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREI
CCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDP
EISLAESEGVSCHYWSLFDGHAGSGAAVVASRLLQHHITEQLQDIVDILKNSAVLPPTCLGEEPENTPANSRTLTRAASLRGGVGAPGSP
STPPTRFFTEKKIPHECLVIGALESAFKEMDLQIERERSSYNISGGCTALIVICLLGKLYVANAGDSRAIIIRNGEIIPMSSEFTPETER
QRLQYLAFMQPHLLGNEFTHLEFPRRVQRKELGKKMLYRDFNMTGWAYKTIEDEDLKFPLIYGEGKKARVMATIGVTRGLGDHDLKVHDS
NIYIKPFLSSAPEVRIYDLSKYDHGSDDVLILATDGLWDVLSNEEVAEAITQFLPNCDPDDPHRYTLAAQDLVMRARGVLKDRGWRISND

--------------------------------------------------------------
>52415_52415_5_MDM2-PPM1H_MDM2_chr12_69230529_ENST00000356290_PPM1H_chr12_63195940_ENST00000228705_length(transcript)=6336nt_BP=695nt
GCACCGCGGCGAGCTTGGCTGCTTCTGGGGCCTGTGTGGCCCTGTGTGTCGGAAAGATGGAGCAAGAAGCCGAGCCCGAGGGGCGGCCGC
GACCCCTCTGACCGAGATCCTGCTGCTTTCGCAGCCAGGAGCACCGTCCCTCCCCGGATTAGTGCGTACGAGCGCCCAGTGCCCTGGCCC
GGAGAGTGGAATGATCCCCGAGGCCCAGGGCGTCGTGCTTCCGCGCGCCCCGTGAAGGAAACTGGGGAGTCTTGAGGGACCCCCGACTCC
AAGCGCGAAAACCCCGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGA
TTCCAGCTTCGGAACAAGAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATA
CTATGAAAGAGGATCTTGATGCTGGTGTAAGTGAACATTCAGGTGATTGGTTGGATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAAT
TTGAAGTTGAATCTCTCGACTCAGAAGATTATAGCCTTAGTGAAGAAGGACAAGAACTCTCAGATGAAGATGATGAGGTATATCAAGTTA
CTGTGTATCAGGCAGGGGAGAGTGATACAGATTCATTTGAAGAAGATCCTGAAATTTCCTTAGCTGAATCCGAGGGTGTTTCCTGCCACT
ATTGGTCGCTGTTTGACGGGCACGCGGGGTCCGGGGCCGCGGTGGTGGCGTCACGCCTGCTGCAGCACCACATCACGGAGCAGCTGCAGG
ACATCGTGGACATCCTGAAGAACTCCGCCGTCCTGCCCCCTACCTGCCTGGGGGAGGAGCCTGAGAACACGCCCGCCAACAGCCGGACTC
TGACCCGGGCAGCCTCCCTGCGCGGAGGGGTGGGGGCCCCGGGCTCCCCCAGCACGCCCCCCACACGCTTCTTTACCGAGAAGAAGATTC
CCCATGAGTGCCTGGTCATCGGAGCGCTTGAAAGTGCATTCAAGGAAATGGACCTACAGATAGAACGAGAGAGGAGTTCATATAATATAT
CTGGTGGCTGCACGGCCCTCATTGTGATTTGCCTTTTGGGGAAGCTGTATGTTGCAAATGCTGGGGATAGCAGGGCCATAATCATCAGAA
ATGGAGAAATTATCCCCATGTCTTCAGAATTTACCCCCGAGACGGAGCGCCAGCGACTTCAGTACCTGGCATTCATGCAGCCTCACTTGC
TGGGAAATGAGTTCACACATTTGGAGTTTCCAAGGAGAGTACAGAGAAAGGAGCTTGGAAAGAAGATGCTCTACAGGGACTTTAATATGA
CAGGCTGGGCATACAAAACCATTGAGGATGAGGACTTGAAGTTCCCCCTTATATATGGAGAAGGCAAGAAGGCCCGGGTAATGGCAACTA
TTGGAGTGACCAGGGGACTTGGGGACCATGACCTGAAGGTGCATGACTCCAACATCTACATTAAACCATTCCTGTCTTCAGCTCCAGAGG
TAAGAATCTACGATCTTTCAAAATATGATCATGGATCAGATGATGTGCTGATCTTGGCCACTGATGGACTCTGGGACGTTTTATCAAATG
AAGAAGTAGCAGAAGCAATCACTCAGTTTCTTCCTAACTGTGATCCAGATGATCCTCACAGGTACACACTGGCAGCTCAGGACCTGGTGA
TGCGTGCCCGGGGTGTGCTGAAGGACAGAGGATGGCGGATATCTAATGACCGACTGGGCTCAGGAGACGACATTTCTGTATATGTCATTC
CTTTAATACATGGAAACAAGCTGTCATGAAAATGGCCCAGGGGATTGGGAGGACAGAGGGGAAGAAAGCTGGGATGCCTCTTGGCAGGAC
GGAACTGGGAAGTGCCCCAGCTGAGTTCCAAGTGATGCAGTCTCTTCCCAGCCCAAGCGGGGAGTTCATGGCCAAAAGACTATGCTTCAA
GATGACCCTTTGGTTTCCATTTCTTCTTTAGTAACAGGTCAACTCAACAAGAGCAAAACACAAAGGCTGCTACCAAGTGTTGTTGTATTT
CAGTTCCTTTCATAGGCCTCCGAGGTGGCCATTGACTATTTGGGGTATATATGTCATATTTATTTTATCTAGAGTAGCTGGGGCAGCCAT
TTTCAGGTGTAAATGGCAGAGGACTCTTCAGCCTGTCAAGCTGCCAGCTTATCTACGGGTTAAAAAGTGCTGCATTGGAAAGTAGGGGGT
CATGCCTCAAAATGTAAGTAAGTGCCCACCTTCTAGGAAGCCTGAGGTTTATTTCAGGGATTGCCGTCTGCCCCCCGCCCCCCTTCTCTT
TTTTTCTTCTCTGTTTCTATTCTTTTATGGCAGTGGTGGAGTGAGGCAGGGATTTTTTTTTTTTTTTTTCGTGTTTTTGACATTCCTTGA
ATCTGTTTTTTATTCCCCTTCCACAGAACAGGCCTGGGACTTTCCAACACCCTGCTAAGGAAGTTCTGTGTCCAAGTCCCACCCAGGCTG
GGTTGTCCCCACCTCCTCCAGCCCACACAGCCCAGGCAGCATCCGGGCCAGTGCCCTGCATGACAGAGGGTCTTTGTTGTGTAATGTTTG
TTCCCAAGTTGCATTTTCTAACCGAATCAGTGTGTTTTCATGAAACTGAGTGTTTCTGTGGACCAGTAGTTCCTCTGTTGTCTTCAGTGG
TCTTCCTGTGTGGCTCAAGGGTTCTCTGTGAGAGTCTGGATTTTCATTTCTGGAATGGCTGGCCCCATCCCACTTTTCTGTATCATGGGG
ACACATATAAAGCAGTGTTTAATAGAGCAGTTTAAGAAGTTGCTTGCATCTGTTGGTTCACCATGGCTCATCTGGGGACCATTTTGGATT
CATGTTTCATGGCTTGTGACTGTCCCCAAGCCCACTCCAAACAAAGTGTAAGGATCAGAGTTCTGTCAAGGAGCAGCAGTTCTGCTCTCC
CCATCATCTTTGTGCAAGGCCCCTCGGGGGGCACTTTAATAAAAGAATTTGAAATGGGTTGACTGGCCATTCTCATGCTGTGCTCCCTGT
CTCTTCTCTTCTCTAAAGAATCATGTCCCAGCTCCTCAAGGTCCCTCTATGGTTCCACATCTGAGTGTTCGCCACAAGAGCAGCAGCAGC
AGGCACAGTGCATGCCATATCTACCTGCTGCTTCTCTGCTGGGAGGAATGGCCAAGTAGATTATAAAACTCACTTCTGTCTCTTAGGCAG
ACTTGTACGGCCACAAAATTACCTAGTCTTCTTCCTGCTGAGCTACTGAGGTATTGCCACCATTTTGACAACTTTGAGTAATTAAAACAC
TCTTCTGACCCAAAAAGGAAAAAAGGTCACTGACGTGACCCCCCCAGCATGCTAGAGAGCTAATTCCAGTTCTCATATTTGTTTGAATTT
CTTCCCAGAGGAGAGGATAGGAACCTCTCCTCCAGGGCAGTAAATCACCTGCATTTCTGGAGTTGTCGGTATTGTATTCGAAAAGGCCTG
GAGCCCCTCCTGCTCAGGAAAGAACTCATTCCAGGGTGTGGAGACAGTGCCGTCTGGCAGGTGAAATACTGTGGGAATTCACGCCACCAG
GTGTTTGTGCAAGTGTTGGCCTGGGAAGAATGGGACTTCGGCCTTGTCAGGAGTTGTCTTCATCTGCAGCACGTTTCTTCCTCCTGCAGT
AGATCTTAGCTACCCCAGATATCTCTATGGAGAGAAGTTTGTGGAAAATGCTTTGCTTCGTGGCAGAGTCTGATGCTGTAGGAAAACCTT
CGGGCATGTGACAGCAGTGTGGTCCACTCCCTGTTCTGCCCTGGCACTCAGAGTCATGTGTAAGTAGGAAACCTGAGCAAGTCTTCCGTG
GAGGACCCTGAGCTGCCGTCTTTGGGATCCTTCCTGTGTCCCCACCGTCTTTCATTTATTTGCTTTCCTGGGCCTCTATCTGGGCCCTAC
CTTGAGCTTCTCCAGTTTTATTCAAGCCACCAGAGTAAGAATTTGGGTGTAGATGTCACAACTACCTTCTACTCAATTCACCAATTCATT
TACTGCTATGGCACGTCTCAGGAATAACTCTAGAAACCTCTAAATCGAAATATTATAAAATCTTGAGCACTTAGTCCTGCTGGTTTTAGT
TAGAAAGGCATCCAGGAATTGTTTTCCTACGCCCCCTTGAGTGGAAAGATCTTAGTTAGAAGATAAAGTCAAGTTTGTGTTCAGGGGATG
GGAGGAAGACTATAAATAAGATGAAGAAATCAAAAGTAGGAAACATGATGTAAACGAAGCATGGCAGATCTGTCCAGCACTGATATTGCT
CTATAAATTGAGCTTACTCAGTTTTGGCCTTATTTTTTTACCCAGGCCCCATGTCACCCAGTCCTAAAACAGTAACCGTGTCTACATAAC
GGGTTGGCCCCTGGTGCATCCCTGGAAAAGTCAAAGGACGCACACTTCGAAATTCTGCAGAACGTATTTATACATGGTTCAGAAATCTTG
CGTATCTGACTTATAGCCAAATCTGCTTGCTCGAATAGCCTCAGAGGAAGTCTTGTTTAATAAAAACCTTTTGATTTCCTAGTCAAGTCT
TTATGGTTGTCTCGAGGGGTGTGTGGCTACTTTAATGAAAGGCTTTCCTGCTCTAAATCTCTTTGCTGGGCTGGGCCTCTTCAGACTATC
TGGTGAAACTCCTTTCCTTAGAACAAACTCAGTCCGTCCATGCTCTGTGGCATTTTGCTAGATGATAACCAAAGCCTTATTCCTGTAGCC
AGTGTCAGCAGTCAGAGAGGTGGAGGGTGTGTTCTGCTGTGGTTATGCATACCTATCTGCTGTTCTTGAGGTGTAAAAGGAAAGGTGAAA
ATCGGGCCAGGCCAAGTACTCAGCTGTCTTAATAGGATGAAGCCTTAAGCAGTGGAAATTTCAGTTATTTTCCACAGTATTCCATTTTGG
AGGATTTGGGGTGTTTACTTTTTAAATTCTTGAACAACTTAACCTCCATGAGGCTTTGTGAAGTCAGCTGTGACCACCCTCCTCTTACTG
TGTTCTCAGTATTCATTCACTTCCAGGGAAGAATGACAGCCACAGGGAGATGGTGGTGGGCAAGAATGAGAGTCCCAGGATCCAGATTTA
GCCTCAGATCTTCCCCATTCAGGAAGGGTTTTCCATTTAACAAGAGCACTAGTATGAAAACATTAGGGACAAATCTCCCATGTCTTTGAA
ATTCGGATTCTCCTCTTGAGATCCCCTTCCTCACCTGCCAATCAACTTTATAAGGCCACAAGTGGTCACTGGTTTTCCTTCCACAGGTTT
GAGGTTCTCAGCTTTCCTTAAGCGACCCAGCAGCTCCGCTGTTTTCAGAGTGAATATGTTAAGCTTTGATGAGATTCTATTTTCAGTAAG
TTAGTGCTTCTGGGACACTTGGAGAAAGCTGTGAGAGTCATTGTCTACGCAAAGAACAACGAAGCTGATCCTAAAAGTGATCCAATCTAA
GAAAATGGTAAAACGAGCTCTGGCCACAGCACAGAATTTTATGTGAGGAACTCAGATTTTTGAAGACTTAACAATTGCAGAGAAAGGTTG
CAGCCTGCACACCATAGCCCACCTCTCTGAGCAGACTTTGGTTTTGTGTGGTGACGTGGCACATGTTTGTACACTGGGATTTTTCAAAGG
ACGCTACGCGAGCAGACTGACTTGCCTCTTCTGTGAGCACTGTGGCTTTTGTCAGATGGAGTGCCGGTCTGCAGAGGACTGCTCTTTCGA
ATCCACAGTGTTATCTGTGTAAATAGCTTTAATTTTTCTTCTGTGTCTTAGGTGAAGTTTTGTTCATGTAGCAACCAGGTAGACAGTGAC
CAAATAAGGCTGTAAATGTGCTGTAGTTTTCTACTGTGATGTACTTGAAGGAGAACCTGTGTCCTCTACTTTTCTGATCTCCCACAAGTA
TTTTGTGTTTGTTTCCTGAGTCCTGAGGTTATTATTTTACTCCTGTTTTGCCCCCAGTTTTCTTTGTTTTTTTTCTGGAGACCCAGGGAG
GCCCATGGTGGAGATCATTTGTAAGGAATGGATCATGGTCTGGGTTTCCAAAACTACCCTAGTACAGTGAATGAGAGAAATCTGCCTGGA
AATTGTTTCAGAACCATGTACCTTTATGCTTTGTGATTGTGAAACATTGACTTTTTTGTAACCCCAAAATGAAAACTGTTTAGTAAAGGG
GATCTATTTTGTGTGTTTTGAAACTTAGGTGCAATGTCCCCTGGAAAAAGCTAAAGAAATGTATATGTTCAATGACATTTTAAAATAAAA

>52415_52415_5_MDM2-PPM1H_MDM2_chr12_69230529_ENST00000356290_PPM1H_chr12_63195940_ENST00000228705_length(amino acids)=525AA_BP=148
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEDLDAGVSEHSGDWLDQDSVS
DQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLAESEGVSCHYWSLFDGHAGSGAAVVASRLLQHH
ITEQLQDIVDILKNSAVLPPTCLGEEPENTPANSRTLTRAASLRGGVGAPGSPSTPPTRFFTEKKIPHECLVIGALESAFKEMDLQIERE
RSSYNISGGCTALIVICLLGKLYVANAGDSRAIIIRNGEIIPMSSEFTPETERQRLQYLAFMQPHLLGNEFTHLEFPRRVQRKELGKKML
YRDFNMTGWAYKTIEDEDLKFPLIYGEGKKARVMATIGVTRGLGDHDLKVHDSNIYIKPFLSSAPEVRIYDLSKYDHGSDDVLILATDGL

--------------------------------------------------------------
>52415_52415_6_MDM2-PPM1H_MDM2_chr12_69230529_ENST00000360430_PPM1H_chr12_63195940_ENST00000228705_length(transcript)=5956nt_BP=315nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGATCTTGAT
GCTGGTGTAAGTGAACATTCAGGTGATTGGTTGGATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAATTTGAAGTTGAATCTCTCGAC
TCAGAAGATTATAGCCTTAGTGAAGAAGGACAAGAACTCTCAGATGAAGATGATGAGGTATATCAAGTTACTGTGTATCAGGCAGGGGAG
AGTGATACAGATTCATTTGAAGAAGATCCTGAAATTTCCTTAGCTGAATCCGAGGGTGTTTCCTGCCACTATTGGTCGCTGTTTGACGGG
CACGCGGGGTCCGGGGCCGCGGTGGTGGCGTCACGCCTGCTGCAGCACCACATCACGGAGCAGCTGCAGGACATCGTGGACATCCTGAAG
AACTCCGCCGTCCTGCCCCCTACCTGCCTGGGGGAGGAGCCTGAGAACACGCCCGCCAACAGCCGGACTCTGACCCGGGCAGCCTCCCTG
CGCGGAGGGGTGGGGGCCCCGGGCTCCCCCAGCACGCCCCCCACACGCTTCTTTACCGAGAAGAAGATTCCCCATGAGTGCCTGGTCATC
GGAGCGCTTGAAAGTGCATTCAAGGAAATGGACCTACAGATAGAACGAGAGAGGAGTTCATATAATATATCTGGTGGCTGCACGGCCCTC
ATTGTGATTTGCCTTTTGGGGAAGCTGTATGTTGCAAATGCTGGGGATAGCAGGGCCATAATCATCAGAAATGGAGAAATTATCCCCATG
TCTTCAGAATTTACCCCCGAGACGGAGCGCCAGCGACTTCAGTACCTGGCATTCATGCAGCCTCACTTGCTGGGAAATGAGTTCACACAT
TTGGAGTTTCCAAGGAGAGTACAGAGAAAGGAGCTTGGAAAGAAGATGCTCTACAGGGACTTTAATATGACAGGCTGGGCATACAAAACC
ATTGAGGATGAGGACTTGAAGTTCCCCCTTATATATGGAGAAGGCAAGAAGGCCCGGGTAATGGCAACTATTGGAGTGACCAGGGGACTT
GGGGACCATGACCTGAAGGTGCATGACTCCAACATCTACATTAAACCATTCCTGTCTTCAGCTCCAGAGGTAAGAATCTACGATCTTTCA
AAATATGATCATGGATCAGATGATGTGCTGATCTTGGCCACTGATGGACTCTGGGACGTTTTATCAAATGAAGAAGTAGCAGAAGCAATC
ACTCAGTTTCTTCCTAACTGTGATCCAGATGATCCTCACAGGTACACACTGGCAGCTCAGGACCTGGTGATGCGTGCCCGGGGTGTGCTG
AAGGACAGAGGATGGCGGATATCTAATGACCGACTGGGCTCAGGAGACGACATTTCTGTATATGTCATTCCTTTAATACATGGAAACAAG
CTGTCATGAAAATGGCCCAGGGGATTGGGAGGACAGAGGGGAAGAAAGCTGGGATGCCTCTTGGCAGGACGGAACTGGGAAGTGCCCCAG
CTGAGTTCCAAGTGATGCAGTCTCTTCCCAGCCCAAGCGGGGAGTTCATGGCCAAAAGACTATGCTTCAAGATGACCCTTTGGTTTCCAT
TTCTTCTTTAGTAACAGGTCAACTCAACAAGAGCAAAACACAAAGGCTGCTACCAAGTGTTGTTGTATTTCAGTTCCTTTCATAGGCCTC
CGAGGTGGCCATTGACTATTTGGGGTATATATGTCATATTTATTTTATCTAGAGTAGCTGGGGCAGCCATTTTCAGGTGTAAATGGCAGA
GGACTCTTCAGCCTGTCAAGCTGCCAGCTTATCTACGGGTTAAAAAGTGCTGCATTGGAAAGTAGGGGGTCATGCCTCAAAATGTAAGTA
AGTGCCCACCTTCTAGGAAGCCTGAGGTTTATTTCAGGGATTGCCGTCTGCCCCCCGCCCCCCTTCTCTTTTTTTCTTCTCTGTTTCTAT
TCTTTTATGGCAGTGGTGGAGTGAGGCAGGGATTTTTTTTTTTTTTTTTCGTGTTTTTGACATTCCTTGAATCTGTTTTTTATTCCCCTT
CCACAGAACAGGCCTGGGACTTTCCAACACCCTGCTAAGGAAGTTCTGTGTCCAAGTCCCACCCAGGCTGGGTTGTCCCCACCTCCTCCA
GCCCACACAGCCCAGGCAGCATCCGGGCCAGTGCCCTGCATGACAGAGGGTCTTTGTTGTGTAATGTTTGTTCCCAAGTTGCATTTTCTA
ACCGAATCAGTGTGTTTTCATGAAACTGAGTGTTTCTGTGGACCAGTAGTTCCTCTGTTGTCTTCAGTGGTCTTCCTGTGTGGCTCAAGG
GTTCTCTGTGAGAGTCTGGATTTTCATTTCTGGAATGGCTGGCCCCATCCCACTTTTCTGTATCATGGGGACACATATAAAGCAGTGTTT
AATAGAGCAGTTTAAGAAGTTGCTTGCATCTGTTGGTTCACCATGGCTCATCTGGGGACCATTTTGGATTCATGTTTCATGGCTTGTGAC
TGTCCCCAAGCCCACTCCAAACAAAGTGTAAGGATCAGAGTTCTGTCAAGGAGCAGCAGTTCTGCTCTCCCCATCATCTTTGTGCAAGGC
CCCTCGGGGGGCACTTTAATAAAAGAATTTGAAATGGGTTGACTGGCCATTCTCATGCTGTGCTCCCTGTCTCTTCTCTTCTCTAAAGAA
TCATGTCCCAGCTCCTCAAGGTCCCTCTATGGTTCCACATCTGAGTGTTCGCCACAAGAGCAGCAGCAGCAGGCACAGTGCATGCCATAT
CTACCTGCTGCTTCTCTGCTGGGAGGAATGGCCAAGTAGATTATAAAACTCACTTCTGTCTCTTAGGCAGACTTGTACGGCCACAAAATT
ACCTAGTCTTCTTCCTGCTGAGCTACTGAGGTATTGCCACCATTTTGACAACTTTGAGTAATTAAAACACTCTTCTGACCCAAAAAGGAA
AAAAGGTCACTGACGTGACCCCCCCAGCATGCTAGAGAGCTAATTCCAGTTCTCATATTTGTTTGAATTTCTTCCCAGAGGAGAGGATAG
GAACCTCTCCTCCAGGGCAGTAAATCACCTGCATTTCTGGAGTTGTCGGTATTGTATTCGAAAAGGCCTGGAGCCCCTCCTGCTCAGGAA
AGAACTCATTCCAGGGTGTGGAGACAGTGCCGTCTGGCAGGTGAAATACTGTGGGAATTCACGCCACCAGGTGTTTGTGCAAGTGTTGGC
CTGGGAAGAATGGGACTTCGGCCTTGTCAGGAGTTGTCTTCATCTGCAGCACGTTTCTTCCTCCTGCAGTAGATCTTAGCTACCCCAGAT
ATCTCTATGGAGAGAAGTTTGTGGAAAATGCTTTGCTTCGTGGCAGAGTCTGATGCTGTAGGAAAACCTTCGGGCATGTGACAGCAGTGT
GGTCCACTCCCTGTTCTGCCCTGGCACTCAGAGTCATGTGTAAGTAGGAAACCTGAGCAAGTCTTCCGTGGAGGACCCTGAGCTGCCGTC
TTTGGGATCCTTCCTGTGTCCCCACCGTCTTTCATTTATTTGCTTTCCTGGGCCTCTATCTGGGCCCTACCTTGAGCTTCTCCAGTTTTA
TTCAAGCCACCAGAGTAAGAATTTGGGTGTAGATGTCACAACTACCTTCTACTCAATTCACCAATTCATTTACTGCTATGGCACGTCTCA
GGAATAACTCTAGAAACCTCTAAATCGAAATATTATAAAATCTTGAGCACTTAGTCCTGCTGGTTTTAGTTAGAAAGGCATCCAGGAATT
GTTTTCCTACGCCCCCTTGAGTGGAAAGATCTTAGTTAGAAGATAAAGTCAAGTTTGTGTTCAGGGGATGGGAGGAAGACTATAAATAAG
ATGAAGAAATCAAAAGTAGGAAACATGATGTAAACGAAGCATGGCAGATCTGTCCAGCACTGATATTGCTCTATAAATTGAGCTTACTCA
GTTTTGGCCTTATTTTTTTACCCAGGCCCCATGTCACCCAGTCCTAAAACAGTAACCGTGTCTACATAACGGGTTGGCCCCTGGTGCATC
CCTGGAAAAGTCAAAGGACGCACACTTCGAAATTCTGCAGAACGTATTTATACATGGTTCAGAAATCTTGCGTATCTGACTTATAGCCAA
ATCTGCTTGCTCGAATAGCCTCAGAGGAAGTCTTGTTTAATAAAAACCTTTTGATTTCCTAGTCAAGTCTTTATGGTTGTCTCGAGGGGT
GTGTGGCTACTTTAATGAAAGGCTTTCCTGCTCTAAATCTCTTTGCTGGGCTGGGCCTCTTCAGACTATCTGGTGAAACTCCTTTCCTTA
GAACAAACTCAGTCCGTCCATGCTCTGTGGCATTTTGCTAGATGATAACCAAAGCCTTATTCCTGTAGCCAGTGTCAGCAGTCAGAGAGG
TGGAGGGTGTGTTCTGCTGTGGTTATGCATACCTATCTGCTGTTCTTGAGGTGTAAAAGGAAAGGTGAAAATCGGGCCAGGCCAAGTACT
CAGCTGTCTTAATAGGATGAAGCCTTAAGCAGTGGAAATTTCAGTTATTTTCCACAGTATTCCATTTTGGAGGATTTGGGGTGTTTACTT
TTTAAATTCTTGAACAACTTAACCTCCATGAGGCTTTGTGAAGTCAGCTGTGACCACCCTCCTCTTACTGTGTTCTCAGTATTCATTCAC
TTCCAGGGAAGAATGACAGCCACAGGGAGATGGTGGTGGGCAAGAATGAGAGTCCCAGGATCCAGATTTAGCCTCAGATCTTCCCCATTC
AGGAAGGGTTTTCCATTTAACAAGAGCACTAGTATGAAAACATTAGGGACAAATCTCCCATGTCTTTGAAATTCGGATTCTCCTCTTGAG
ATCCCCTTCCTCACCTGCCAATCAACTTTATAAGGCCACAAGTGGTCACTGGTTTTCCTTCCACAGGTTTGAGGTTCTCAGCTTTCCTTA
AGCGACCCAGCAGCTCCGCTGTTTTCAGAGTGAATATGTTAAGCTTTGATGAGATTCTATTTTCAGTAAGTTAGTGCTTCTGGGACACTT
GGAGAAAGCTGTGAGAGTCATTGTCTACGCAAAGAACAACGAAGCTGATCCTAAAAGTGATCCAATCTAAGAAAATGGTAAAACGAGCTC
TGGCCACAGCACAGAATTTTATGTGAGGAACTCAGATTTTTGAAGACTTAACAATTGCAGAGAAAGGTTGCAGCCTGCACACCATAGCCC
ACCTCTCTGAGCAGACTTTGGTTTTGTGTGGTGACGTGGCACATGTTTGTACACTGGGATTTTTCAAAGGACGCTACGCGAGCAGACTGA
CTTGCCTCTTCTGTGAGCACTGTGGCTTTTGTCAGATGGAGTGCCGGTCTGCAGAGGACTGCTCTTTCGAATCCACAGTGTTATCTGTGT
AAATAGCTTTAATTTTTCTTCTGTGTCTTAGGTGAAGTTTTGTTCATGTAGCAACCAGGTAGACAGTGACCAAATAAGGCTGTAAATGTG
CTGTAGTTTTCTACTGTGATGTACTTGAAGGAGAACCTGTGTCCTCTACTTTTCTGATCTCCCACAAGTATTTTGTGTTTGTTTCCTGAG
TCCTGAGGTTATTATTTTACTCCTGTTTTGCCCCCAGTTTTCTTTGTTTTTTTTCTGGAGACCCAGGGAGGCCCATGGTGGAGATCATTT
GTAAGGAATGGATCATGGTCTGGGTTTCCAAAACTACCCTAGTACAGTGAATGAGAGAAATCTGCCTGGAAATTGTTTCAGAACCATGTA
CCTTTATGCTTTGTGATTGTGAAACATTGACTTTTTTGTAACCCCAAAATGAAAACTGTTTAGTAAAGGGGATCTATTTTGTGTGTTTTG
AAACTTAGGTGCAATGTCCCCTGGAAAAAGCTAAAGAAATGTATATGTTCAATGACATTTTAAAATAAAATATTATATATATGTATATAC

>52415_52415_6_MDM2-PPM1H_MDM2_chr12_69230529_ENST00000360430_PPM1H_chr12_63195940_ENST00000228705_length(amino acids)=482AA_BP=105
MCNTNMSVPTDGAVTTSQIPASEQETLDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGE
SDTDSFEEDPEISLAESEGVSCHYWSLFDGHAGSGAAVVASRLLQHHITEQLQDIVDILKNSAVLPPTCLGEEPENTPANSRTLTRAASL
RGGVGAPGSPSTPPTRFFTEKKIPHECLVIGALESAFKEMDLQIERERSSYNISGGCTALIVICLLGKLYVANAGDSRAIIIRNGEIIPM
SSEFTPETERQRLQYLAFMQPHLLGNEFTHLEFPRRVQRKELGKKMLYRDFNMTGWAYKTIEDEDLKFPLIYGEGKKARVMATIGVTRGL
GDHDLKVHDSNIYIKPFLSSAPEVRIYDLSKYDHGSDDVLILATDGLWDVLSNEEVAEAITQFLPNCDPDDPHRYTLAAQDLVMRARGVL

--------------------------------------------------------------
>52415_52415_7_MDM2-PPM1H_MDM2_chr12_69230529_ENST00000462284_PPM1H_chr12_63195940_ENST00000228705_length(transcript)=6861nt_BP=1220nt
GGGGCGCGCACCGAGGCACCGCGGCGAGCTTGGCTGCTTCTGGGGCCTGTGTGGCCCTGTGTGTCGGAAAGATGGAGCAAGAAGCCGAGC
CCGAGGGGCGGCCGCGACCCCTCTGACCGAGATCCTGCTGCTTTCGCAGCCAGGAGCACCGTCCCTCCCCGGATTAGTGCGTACGAGCGC
CCAGTGCCCTGGCCCGGAGAGTGGAATGATCCCCGAGGCCCAGGGCGTCGTGCTTCCGCGCGCCCCGTGAAGGAAACTGGGGAGTCTTGA
GGGACCCCCGACTCCAAGCGCGAAAACCCCGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTG
TAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCAC
AAAAAGACACTTATACTATGAAAGAGGTTCTTTTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATA
TTGTATATTGTTCAAATGATCTTCTAGGAGATTTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCT
ACAGGAACTTGGTAGTAGTCAATCAGCAGGAATCATCGGACTCAGGTACATCTGTGAGTGAGAACAGGTGTCACCTTGAAGGTGGGAGTG
ATCAAAAGGACCTTGTACAAGAGCTTCAGGAAGAGAAACCTTCATCTTCACATTTGGTTTCTAGACCATCTACCTCATCTAGAAGGAGAG
CAATTAGTGAGACAGAAGAAAATTCAGATGAATTATCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTG
ATGAAAGCCTGGCTCTGTGTGTAATAAGGGAGATATGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGGATC
TTGATGCTGGTGTAAGTGAACATTCAGGTGATTGGTTGGATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAATTTGAAGTTGAATCTC
TCGACTCAGAAGATTATAGCCTTAGTGAAGAAGGACAAGAACTCTCAGATGAAGATGATGAGGTATATCAAGTTACTGTGTATCAGGCAG
GGGAGAGTGATACAGATTCATTTGAAGAAGATCCTGAAATTTCCTTAGCTGAATCCGAGGGTGTTTCCTGCCACTATTGGTCGCTGTTTG
ACGGGCACGCGGGGTCCGGGGCCGCGGTGGTGGCGTCACGCCTGCTGCAGCACCACATCACGGAGCAGCTGCAGGACATCGTGGACATCC
TGAAGAACTCCGCCGTCCTGCCCCCTACCTGCCTGGGGGAGGAGCCTGAGAACACGCCCGCCAACAGCCGGACTCTGACCCGGGCAGCCT
CCCTGCGCGGAGGGGTGGGGGCCCCGGGCTCCCCCAGCACGCCCCCCACACGCTTCTTTACCGAGAAGAAGATTCCCCATGAGTGCCTGG
TCATCGGAGCGCTTGAAAGTGCATTCAAGGAAATGGACCTACAGATAGAACGAGAGAGGAGTTCATATAATATATCTGGTGGCTGCACGG
CCCTCATTGTGATTTGCCTTTTGGGGAAGCTGTATGTTGCAAATGCTGGGGATAGCAGGGCCATAATCATCAGAAATGGAGAAATTATCC
CCATGTCTTCAGAATTTACCCCCGAGACGGAGCGCCAGCGACTTCAGTACCTGGCATTCATGCAGCCTCACTTGCTGGGAAATGAGTTCA
CACATTTGGAGTTTCCAAGGAGAGTACAGAGAAAGGAGCTTGGAAAGAAGATGCTCTACAGGGACTTTAATATGACAGGCTGGGCATACA
AAACCATTGAGGATGAGGACTTGAAGTTCCCCCTTATATATGGAGAAGGCAAGAAGGCCCGGGTAATGGCAACTATTGGAGTGACCAGGG
GACTTGGGGACCATGACCTGAAGGTGCATGACTCCAACATCTACATTAAACCATTCCTGTCTTCAGCTCCAGAGGTAAGAATCTACGATC
TTTCAAAATATGATCATGGATCAGATGATGTGCTGATCTTGGCCACTGATGGACTCTGGGACGTTTTATCAAATGAAGAAGTAGCAGAAG
CAATCACTCAGTTTCTTCCTAACTGTGATCCAGATGATCCTCACAGGTACACACTGGCAGCTCAGGACCTGGTGATGCGTGCCCGGGGTG
TGCTGAAGGACAGAGGATGGCGGATATCTAATGACCGACTGGGCTCAGGAGACGACATTTCTGTATATGTCATTCCTTTAATACATGGAA
ACAAGCTGTCATGAAAATGGCCCAGGGGATTGGGAGGACAGAGGGGAAGAAAGCTGGGATGCCTCTTGGCAGGACGGAACTGGGAAGTGC
CCCAGCTGAGTTCCAAGTGATGCAGTCTCTTCCCAGCCCAAGCGGGGAGTTCATGGCCAAAAGACTATGCTTCAAGATGACCCTTTGGTT
TCCATTTCTTCTTTAGTAACAGGTCAACTCAACAAGAGCAAAACACAAAGGCTGCTACCAAGTGTTGTTGTATTTCAGTTCCTTTCATAG
GCCTCCGAGGTGGCCATTGACTATTTGGGGTATATATGTCATATTTATTTTATCTAGAGTAGCTGGGGCAGCCATTTTCAGGTGTAAATG
GCAGAGGACTCTTCAGCCTGTCAAGCTGCCAGCTTATCTACGGGTTAAAAAGTGCTGCATTGGAAAGTAGGGGGTCATGCCTCAAAATGT
AAGTAAGTGCCCACCTTCTAGGAAGCCTGAGGTTTATTTCAGGGATTGCCGTCTGCCCCCCGCCCCCCTTCTCTTTTTTTCTTCTCTGTT
TCTATTCTTTTATGGCAGTGGTGGAGTGAGGCAGGGATTTTTTTTTTTTTTTTTCGTGTTTTTGACATTCCTTGAATCTGTTTTTTATTC
CCCTTCCACAGAACAGGCCTGGGACTTTCCAACACCCTGCTAAGGAAGTTCTGTGTCCAAGTCCCACCCAGGCTGGGTTGTCCCCACCTC
CTCCAGCCCACACAGCCCAGGCAGCATCCGGGCCAGTGCCCTGCATGACAGAGGGTCTTTGTTGTGTAATGTTTGTTCCCAAGTTGCATT
TTCTAACCGAATCAGTGTGTTTTCATGAAACTGAGTGTTTCTGTGGACCAGTAGTTCCTCTGTTGTCTTCAGTGGTCTTCCTGTGTGGCT
CAAGGGTTCTCTGTGAGAGTCTGGATTTTCATTTCTGGAATGGCTGGCCCCATCCCACTTTTCTGTATCATGGGGACACATATAAAGCAG
TGTTTAATAGAGCAGTTTAAGAAGTTGCTTGCATCTGTTGGTTCACCATGGCTCATCTGGGGACCATTTTGGATTCATGTTTCATGGCTT
GTGACTGTCCCCAAGCCCACTCCAAACAAAGTGTAAGGATCAGAGTTCTGTCAAGGAGCAGCAGTTCTGCTCTCCCCATCATCTTTGTGC
AAGGCCCCTCGGGGGGCACTTTAATAAAAGAATTTGAAATGGGTTGACTGGCCATTCTCATGCTGTGCTCCCTGTCTCTTCTCTTCTCTA
AAGAATCATGTCCCAGCTCCTCAAGGTCCCTCTATGGTTCCACATCTGAGTGTTCGCCACAAGAGCAGCAGCAGCAGGCACAGTGCATGC
CATATCTACCTGCTGCTTCTCTGCTGGGAGGAATGGCCAAGTAGATTATAAAACTCACTTCTGTCTCTTAGGCAGACTTGTACGGCCACA
AAATTACCTAGTCTTCTTCCTGCTGAGCTACTGAGGTATTGCCACCATTTTGACAACTTTGAGTAATTAAAACACTCTTCTGACCCAAAA
AGGAAAAAAGGTCACTGACGTGACCCCCCCAGCATGCTAGAGAGCTAATTCCAGTTCTCATATTTGTTTGAATTTCTTCCCAGAGGAGAG
GATAGGAACCTCTCCTCCAGGGCAGTAAATCACCTGCATTTCTGGAGTTGTCGGTATTGTATTCGAAAAGGCCTGGAGCCCCTCCTGCTC
AGGAAAGAACTCATTCCAGGGTGTGGAGACAGTGCCGTCTGGCAGGTGAAATACTGTGGGAATTCACGCCACCAGGTGTTTGTGCAAGTG
TTGGCCTGGGAAGAATGGGACTTCGGCCTTGTCAGGAGTTGTCTTCATCTGCAGCACGTTTCTTCCTCCTGCAGTAGATCTTAGCTACCC
CAGATATCTCTATGGAGAGAAGTTTGTGGAAAATGCTTTGCTTCGTGGCAGAGTCTGATGCTGTAGGAAAACCTTCGGGCATGTGACAGC
AGTGTGGTCCACTCCCTGTTCTGCCCTGGCACTCAGAGTCATGTGTAAGTAGGAAACCTGAGCAAGTCTTCCGTGGAGGACCCTGAGCTG
CCGTCTTTGGGATCCTTCCTGTGTCCCCACCGTCTTTCATTTATTTGCTTTCCTGGGCCTCTATCTGGGCCCTACCTTGAGCTTCTCCAG
TTTTATTCAAGCCACCAGAGTAAGAATTTGGGTGTAGATGTCACAACTACCTTCTACTCAATTCACCAATTCATTTACTGCTATGGCACG
TCTCAGGAATAACTCTAGAAACCTCTAAATCGAAATATTATAAAATCTTGAGCACTTAGTCCTGCTGGTTTTAGTTAGAAAGGCATCCAG
GAATTGTTTTCCTACGCCCCCTTGAGTGGAAAGATCTTAGTTAGAAGATAAAGTCAAGTTTGTGTTCAGGGGATGGGAGGAAGACTATAA
ATAAGATGAAGAAATCAAAAGTAGGAAACATGATGTAAACGAAGCATGGCAGATCTGTCCAGCACTGATATTGCTCTATAAATTGAGCTT
ACTCAGTTTTGGCCTTATTTTTTTACCCAGGCCCCATGTCACCCAGTCCTAAAACAGTAACCGTGTCTACATAACGGGTTGGCCCCTGGT
GCATCCCTGGAAAAGTCAAAGGACGCACACTTCGAAATTCTGCAGAACGTATTTATACATGGTTCAGAAATCTTGCGTATCTGACTTATA
GCCAAATCTGCTTGCTCGAATAGCCTCAGAGGAAGTCTTGTTTAATAAAAACCTTTTGATTTCCTAGTCAAGTCTTTATGGTTGTCTCGA
GGGGTGTGTGGCTACTTTAATGAAAGGCTTTCCTGCTCTAAATCTCTTTGCTGGGCTGGGCCTCTTCAGACTATCTGGTGAAACTCCTTT
CCTTAGAACAAACTCAGTCCGTCCATGCTCTGTGGCATTTTGCTAGATGATAACCAAAGCCTTATTCCTGTAGCCAGTGTCAGCAGTCAG
AGAGGTGGAGGGTGTGTTCTGCTGTGGTTATGCATACCTATCTGCTGTTCTTGAGGTGTAAAAGGAAAGGTGAAAATCGGGCCAGGCCAA
GTACTCAGCTGTCTTAATAGGATGAAGCCTTAAGCAGTGGAAATTTCAGTTATTTTCCACAGTATTCCATTTTGGAGGATTTGGGGTGTT
TACTTTTTAAATTCTTGAACAACTTAACCTCCATGAGGCTTTGTGAAGTCAGCTGTGACCACCCTCCTCTTACTGTGTTCTCAGTATTCA
TTCACTTCCAGGGAAGAATGACAGCCACAGGGAGATGGTGGTGGGCAAGAATGAGAGTCCCAGGATCCAGATTTAGCCTCAGATCTTCCC
CATTCAGGAAGGGTTTTCCATTTAACAAGAGCACTAGTATGAAAACATTAGGGACAAATCTCCCATGTCTTTGAAATTCGGATTCTCCTC
TTGAGATCCCCTTCCTCACCTGCCAATCAACTTTATAAGGCCACAAGTGGTCACTGGTTTTCCTTCCACAGGTTTGAGGTTCTCAGCTTT
CCTTAAGCGACCCAGCAGCTCCGCTGTTTTCAGAGTGAATATGTTAAGCTTTGATGAGATTCTATTTTCAGTAAGTTAGTGCTTCTGGGA
CACTTGGAGAAAGCTGTGAGAGTCATTGTCTACGCAAAGAACAACGAAGCTGATCCTAAAAGTGATCCAATCTAAGAAAATGGTAAAACG
AGCTCTGGCCACAGCACAGAATTTTATGTGAGGAACTCAGATTTTTGAAGACTTAACAATTGCAGAGAAAGGTTGCAGCCTGCACACCAT
AGCCCACCTCTCTGAGCAGACTTTGGTTTTGTGTGGTGACGTGGCACATGTTTGTACACTGGGATTTTTCAAAGGACGCTACGCGAGCAG
ACTGACTTGCCTCTTCTGTGAGCACTGTGGCTTTTGTCAGATGGAGTGCCGGTCTGCAGAGGACTGCTCTTTCGAATCCACAGTGTTATC
TGTGTAAATAGCTTTAATTTTTCTTCTGTGTCTTAGGTGAAGTTTTGTTCATGTAGCAACCAGGTAGACAGTGACCAAATAAGGCTGTAA
ATGTGCTGTAGTTTTCTACTGTGATGTACTTGAAGGAGAACCTGTGTCCTCTACTTTTCTGATCTCCCACAAGTATTTTGTGTTTGTTTC
CTGAGTCCTGAGGTTATTATTTTACTCCTGTTTTGCCCCCAGTTTTCTTTGTTTTTTTTCTGGAGACCCAGGGAGGCCCATGGTGGAGAT
CATTTGTAAGGAATGGATCATGGTCTGGGTTTCCAAAACTACCCTAGTACAGTGAATGAGAGAAATCTGCCTGGAAATTGTTTCAGAACC
ATGTACCTTTATGCTTTGTGATTGTGAAACATTGACTTTTTTGTAACCCCAAAATGAAAACTGTTTAGTAAAGGGGATCTATTTTGTGTG
TTTTGAAACTTAGGTGCAATGTCCCCTGGAAAAAGCTAAAGAAATGTATATGTTCAATGACATTTTAAAATAAAATATTATATATATGTA

>52415_52415_7_MDM2-PPM1H_MDM2_chr12_69230529_ENST00000462284_PPM1H_chr12_63195940_ENST00000228705_length(amino acids)=695AA_BP=318
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQ
HIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRR
RAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVE
SLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLAESEGVSCHYWSLFDGHAGSGAAVVASRLLQHHITEQLQDIVD
ILKNSAVLPPTCLGEEPENTPANSRTLTRAASLRGGVGAPGSPSTPPTRFFTEKKIPHECLVIGALESAFKEMDLQIERERSSYNISGGC
TALIVICLLGKLYVANAGDSRAIIIRNGEIIPMSSEFTPETERQRLQYLAFMQPHLLGNEFTHLEFPRRVQRKELGKKMLYRDFNMTGWA
YKTIEDEDLKFPLIYGEGKKARVMATIGVTRGLGDHDLKVHDSNIYIKPFLSSAPEVRIYDLSKYDHGSDDVLILATDGLWDVLSNEEVA

--------------------------------------------------------------
>52415_52415_8_MDM2-PPM1H_MDM2_chr12_69230529_ENST00000540827_PPM1H_chr12_63195940_ENST00000228705_length(transcript)=6261nt_BP=620nt
GCACCGCGGCGAGCTTGGCTGCTTCTGGGGCCTGTGTGGCCCTGTGTGTCGGAAAGATGGAGCAAGAAGCCGAGCCCGAGGGGCGGCCGC
GACCCCTCTGACCGAGATCCTGCTGCTTTCGCAGCCAGGAGCACCGTCCCTCCCCGGATTAGTGCGTACGAGCGCCCAGTGCCCTGGCCC
GGAGAGTGGAATGATCCCCGAGGCCCAGGGCGTCGTGCTTCCGCGCGCCCCGTGAAGGAAACTGGGGAGTCTTGAGGGACCCCCGACTCC
AAGCGCGAAAACCCCGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGA
TTCCAGCTTCGGAACAAGAGACCCTGGATCTTGATGCTGGTGTAAGTGAACATTCAGGTGATTGGTTGGATCAGGATTCAGTTTCAGATC
AGTTTAGTGTAGAATTTGAAGTTGAATCTCTCGACTCAGAAGATTATAGCCTTAGTGAAGAAGGACAAGAACTCTCAGATGAAGATGATG
AGGTATATCAAGTTACTGTGTATCAGGCAGGGGAGAGTGATACAGATTCATTTGAAGAAGATCCTGAAATTTCCTTAGCTGAATCCGAGG
GTGTTTCCTGCCACTATTGGTCGCTGTTTGACGGGCACGCGGGGTCCGGGGCCGCGGTGGTGGCGTCACGCCTGCTGCAGCACCACATCA
CGGAGCAGCTGCAGGACATCGTGGACATCCTGAAGAACTCCGCCGTCCTGCCCCCTACCTGCCTGGGGGAGGAGCCTGAGAACACGCCCG
CCAACAGCCGGACTCTGACCCGGGCAGCCTCCCTGCGCGGAGGGGTGGGGGCCCCGGGCTCCCCCAGCACGCCCCCCACACGCTTCTTTA
CCGAGAAGAAGATTCCCCATGAGTGCCTGGTCATCGGAGCGCTTGAAAGTGCATTCAAGGAAATGGACCTACAGATAGAACGAGAGAGGA
GTTCATATAATATATCTGGTGGCTGCACGGCCCTCATTGTGATTTGCCTTTTGGGGAAGCTGTATGTTGCAAATGCTGGGGATAGCAGGG
CCATAATCATCAGAAATGGAGAAATTATCCCCATGTCTTCAGAATTTACCCCCGAGACGGAGCGCCAGCGACTTCAGTACCTGGCATTCA
TGCAGCCTCACTTGCTGGGAAATGAGTTCACACATTTGGAGTTTCCAAGGAGAGTACAGAGAAAGGAGCTTGGAAAGAAGATGCTCTACA
GGGACTTTAATATGACAGGCTGGGCATACAAAACCATTGAGGATGAGGACTTGAAGTTCCCCCTTATATATGGAGAAGGCAAGAAGGCCC
GGGTAATGGCAACTATTGGAGTGACCAGGGGACTTGGGGACCATGACCTGAAGGTGCATGACTCCAACATCTACATTAAACCATTCCTGT
CTTCAGCTCCAGAGGTAAGAATCTACGATCTTTCAAAATATGATCATGGATCAGATGATGTGCTGATCTTGGCCACTGATGGACTCTGGG
ACGTTTTATCAAATGAAGAAGTAGCAGAAGCAATCACTCAGTTTCTTCCTAACTGTGATCCAGATGATCCTCACAGGTACACACTGGCAG
CTCAGGACCTGGTGATGCGTGCCCGGGGTGTGCTGAAGGACAGAGGATGGCGGATATCTAATGACCGACTGGGCTCAGGAGACGACATTT
CTGTATATGTCATTCCTTTAATACATGGAAACAAGCTGTCATGAAAATGGCCCAGGGGATTGGGAGGACAGAGGGGAAGAAAGCTGGGAT
GCCTCTTGGCAGGACGGAACTGGGAAGTGCCCCAGCTGAGTTCCAAGTGATGCAGTCTCTTCCCAGCCCAAGCGGGGAGTTCATGGCCAA
AAGACTATGCTTCAAGATGACCCTTTGGTTTCCATTTCTTCTTTAGTAACAGGTCAACTCAACAAGAGCAAAACACAAAGGCTGCTACCA
AGTGTTGTTGTATTTCAGTTCCTTTCATAGGCCTCCGAGGTGGCCATTGACTATTTGGGGTATATATGTCATATTTATTTTATCTAGAGT
AGCTGGGGCAGCCATTTTCAGGTGTAAATGGCAGAGGACTCTTCAGCCTGTCAAGCTGCCAGCTTATCTACGGGTTAAAAAGTGCTGCAT
TGGAAAGTAGGGGGTCATGCCTCAAAATGTAAGTAAGTGCCCACCTTCTAGGAAGCCTGAGGTTTATTTCAGGGATTGCCGTCTGCCCCC
CGCCCCCCTTCTCTTTTTTTCTTCTCTGTTTCTATTCTTTTATGGCAGTGGTGGAGTGAGGCAGGGATTTTTTTTTTTTTTTTTCGTGTT
TTTGACATTCCTTGAATCTGTTTTTTATTCCCCTTCCACAGAACAGGCCTGGGACTTTCCAACACCCTGCTAAGGAAGTTCTGTGTCCAA
GTCCCACCCAGGCTGGGTTGTCCCCACCTCCTCCAGCCCACACAGCCCAGGCAGCATCCGGGCCAGTGCCCTGCATGACAGAGGGTCTTT
GTTGTGTAATGTTTGTTCCCAAGTTGCATTTTCTAACCGAATCAGTGTGTTTTCATGAAACTGAGTGTTTCTGTGGACCAGTAGTTCCTC
TGTTGTCTTCAGTGGTCTTCCTGTGTGGCTCAAGGGTTCTCTGTGAGAGTCTGGATTTTCATTTCTGGAATGGCTGGCCCCATCCCACTT
TTCTGTATCATGGGGACACATATAAAGCAGTGTTTAATAGAGCAGTTTAAGAAGTTGCTTGCATCTGTTGGTTCACCATGGCTCATCTGG
GGACCATTTTGGATTCATGTTTCATGGCTTGTGACTGTCCCCAAGCCCACTCCAAACAAAGTGTAAGGATCAGAGTTCTGTCAAGGAGCA
GCAGTTCTGCTCTCCCCATCATCTTTGTGCAAGGCCCCTCGGGGGGCACTTTAATAAAAGAATTTGAAATGGGTTGACTGGCCATTCTCA
TGCTGTGCTCCCTGTCTCTTCTCTTCTCTAAAGAATCATGTCCCAGCTCCTCAAGGTCCCTCTATGGTTCCACATCTGAGTGTTCGCCAC
AAGAGCAGCAGCAGCAGGCACAGTGCATGCCATATCTACCTGCTGCTTCTCTGCTGGGAGGAATGGCCAAGTAGATTATAAAACTCACTT
CTGTCTCTTAGGCAGACTTGTACGGCCACAAAATTACCTAGTCTTCTTCCTGCTGAGCTACTGAGGTATTGCCACCATTTTGACAACTTT
GAGTAATTAAAACACTCTTCTGACCCAAAAAGGAAAAAAGGTCACTGACGTGACCCCCCCAGCATGCTAGAGAGCTAATTCCAGTTCTCA
TATTTGTTTGAATTTCTTCCCAGAGGAGAGGATAGGAACCTCTCCTCCAGGGCAGTAAATCACCTGCATTTCTGGAGTTGTCGGTATTGT
ATTCGAAAAGGCCTGGAGCCCCTCCTGCTCAGGAAAGAACTCATTCCAGGGTGTGGAGACAGTGCCGTCTGGCAGGTGAAATACTGTGGG
AATTCACGCCACCAGGTGTTTGTGCAAGTGTTGGCCTGGGAAGAATGGGACTTCGGCCTTGTCAGGAGTTGTCTTCATCTGCAGCACGTT
TCTTCCTCCTGCAGTAGATCTTAGCTACCCCAGATATCTCTATGGAGAGAAGTTTGTGGAAAATGCTTTGCTTCGTGGCAGAGTCTGATG
CTGTAGGAAAACCTTCGGGCATGTGACAGCAGTGTGGTCCACTCCCTGTTCTGCCCTGGCACTCAGAGTCATGTGTAAGTAGGAAACCTG
AGCAAGTCTTCCGTGGAGGACCCTGAGCTGCCGTCTTTGGGATCCTTCCTGTGTCCCCACCGTCTTTCATTTATTTGCTTTCCTGGGCCT
CTATCTGGGCCCTACCTTGAGCTTCTCCAGTTTTATTCAAGCCACCAGAGTAAGAATTTGGGTGTAGATGTCACAACTACCTTCTACTCA
ATTCACCAATTCATTTACTGCTATGGCACGTCTCAGGAATAACTCTAGAAACCTCTAAATCGAAATATTATAAAATCTTGAGCACTTAGT
CCTGCTGGTTTTAGTTAGAAAGGCATCCAGGAATTGTTTTCCTACGCCCCCTTGAGTGGAAAGATCTTAGTTAGAAGATAAAGTCAAGTT
TGTGTTCAGGGGATGGGAGGAAGACTATAAATAAGATGAAGAAATCAAAAGTAGGAAACATGATGTAAACGAAGCATGGCAGATCTGTCC
AGCACTGATATTGCTCTATAAATTGAGCTTACTCAGTTTTGGCCTTATTTTTTTACCCAGGCCCCATGTCACCCAGTCCTAAAACAGTAA
CCGTGTCTACATAACGGGTTGGCCCCTGGTGCATCCCTGGAAAAGTCAAAGGACGCACACTTCGAAATTCTGCAGAACGTATTTATACAT
GGTTCAGAAATCTTGCGTATCTGACTTATAGCCAAATCTGCTTGCTCGAATAGCCTCAGAGGAAGTCTTGTTTAATAAAAACCTTTTGAT
TTCCTAGTCAAGTCTTTATGGTTGTCTCGAGGGGTGTGTGGCTACTTTAATGAAAGGCTTTCCTGCTCTAAATCTCTTTGCTGGGCTGGG
CCTCTTCAGACTATCTGGTGAAACTCCTTTCCTTAGAACAAACTCAGTCCGTCCATGCTCTGTGGCATTTTGCTAGATGATAACCAAAGC
CTTATTCCTGTAGCCAGTGTCAGCAGTCAGAGAGGTGGAGGGTGTGTTCTGCTGTGGTTATGCATACCTATCTGCTGTTCTTGAGGTGTA
AAAGGAAAGGTGAAAATCGGGCCAGGCCAAGTACTCAGCTGTCTTAATAGGATGAAGCCTTAAGCAGTGGAAATTTCAGTTATTTTCCAC
AGTATTCCATTTTGGAGGATTTGGGGTGTTTACTTTTTAAATTCTTGAACAACTTAACCTCCATGAGGCTTTGTGAAGTCAGCTGTGACC
ACCCTCCTCTTACTGTGTTCTCAGTATTCATTCACTTCCAGGGAAGAATGACAGCCACAGGGAGATGGTGGTGGGCAAGAATGAGAGTCC
CAGGATCCAGATTTAGCCTCAGATCTTCCCCATTCAGGAAGGGTTTTCCATTTAACAAGAGCACTAGTATGAAAACATTAGGGACAAATC
TCCCATGTCTTTGAAATTCGGATTCTCCTCTTGAGATCCCCTTCCTCACCTGCCAATCAACTTTATAAGGCCACAAGTGGTCACTGGTTT
TCCTTCCACAGGTTTGAGGTTCTCAGCTTTCCTTAAGCGACCCAGCAGCTCCGCTGTTTTCAGAGTGAATATGTTAAGCTTTGATGAGAT
TCTATTTTCAGTAAGTTAGTGCTTCTGGGACACTTGGAGAAAGCTGTGAGAGTCATTGTCTACGCAAAGAACAACGAAGCTGATCCTAAA
AGTGATCCAATCTAAGAAAATGGTAAAACGAGCTCTGGCCACAGCACAGAATTTTATGTGAGGAACTCAGATTTTTGAAGACTTAACAAT
TGCAGAGAAAGGTTGCAGCCTGCACACCATAGCCCACCTCTCTGAGCAGACTTTGGTTTTGTGTGGTGACGTGGCACATGTTTGTACACT
GGGATTTTTCAAAGGACGCTACGCGAGCAGACTGACTTGCCTCTTCTGTGAGCACTGTGGCTTTTGTCAGATGGAGTGCCGGTCTGCAGA
GGACTGCTCTTTCGAATCCACAGTGTTATCTGTGTAAATAGCTTTAATTTTTCTTCTGTGTCTTAGGTGAAGTTTTGTTCATGTAGCAAC
CAGGTAGACAGTGACCAAATAAGGCTGTAAATGTGCTGTAGTTTTCTACTGTGATGTACTTGAAGGAGAACCTGTGTCCTCTACTTTTCT
GATCTCCCACAAGTATTTTGTGTTTGTTTCCTGAGTCCTGAGGTTATTATTTTACTCCTGTTTTGCCCCCAGTTTTCTTTGTTTTTTTTC
TGGAGACCCAGGGAGGCCCATGGTGGAGATCATTTGTAAGGAATGGATCATGGTCTGGGTTTCCAAAACTACCCTAGTACAGTGAATGAG
AGAAATCTGCCTGGAAATTGTTTCAGAACCATGTACCTTTATGCTTTGTGATTGTGAAACATTGACTTTTTTGTAACCCCAAAATGAAAA
CTGTTTAGTAAAGGGGATCTATTTTGTGTGTTTTGAAACTTAGGTGCAATGTCCCCTGGAAAAAGCTAAAGAAATGTATATGTTCAATGA

>52415_52415_8_MDM2-PPM1H_MDM2_chr12_69230529_ENST00000540827_PPM1H_chr12_63195940_ENST00000228705_length(amino acids)=500AA_BP=123
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQE
LSDEDDEVYQVTVYQAGESDTDSFEEDPEISLAESEGVSCHYWSLFDGHAGSGAAVVASRLLQHHITEQLQDIVDILKNSAVLPPTCLGE
EPENTPANSRTLTRAASLRGGVGAPGSPSTPPTRFFTEKKIPHECLVIGALESAFKEMDLQIERERSSYNISGGCTALIVICLLGKLYVA
NAGDSRAIIIRNGEIIPMSSEFTPETERQRLQYLAFMQPHLLGNEFTHLEFPRRVQRKELGKKMLYRDFNMTGWAYKTIEDEDLKFPLIY
GEGKKARVMATIGVTRGLGDHDLKVHDSNIYIKPFLSSAPEVRIYDLSKYDHGSDDVLILATDGLWDVLSNEEVAEAITQFLPNCDPDDP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MDM2-PPM1H


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneMDM2chr12:69230529chr12:63195940ENST00000462284+1011170_306306.0498.0MTBP
HgeneMDM2chr12:69230529chr12:63195940ENST00000258149+89150_230245.0437.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69230529chr12:63195940ENST00000462284+1011150_230306.0498.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69230529chr12:63195940ENST00000258149+89223_232245.0437.0USP7
HgeneMDM2chr12:69230529chr12:63195940ENST00000462284+1011223_232306.0498.0USP7


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMDM2chr12:69230529chr12:63195940ENST00000258149+89170_306245.0437.0MTBP
HgeneMDM2chr12:69230529chr12:63195940ENST00000299252+45170_306130.0322.0MTBP
HgeneMDM2chr12:69230529chr12:63195940ENST00000348801+13170_3060.0266.0MTBP
HgeneMDM2chr12:69230529chr12:63195940ENST00000356290+56170_306130.0322.0MTBP
HgeneMDM2chr12:69230529chr12:63195940ENST00000360430+34170_306105.0297.0MTBP
HgeneMDM2chr12:69230529chr12:63195940ENST00000393412+13170_3060219.0MTBP
HgeneMDM2chr12:69230529chr12:63195940ENST00000393413+12170_3060.0219.0MTBP
HgeneMDM2chr12:69230529chr12:63195940ENST00000428863+14170_3060271.0MTBP
HgeneMDM2chr12:69230529chr12:63195940ENST00000540827+45170_306105.0297.0MTBP
HgeneMDM2chr12:69230529chr12:63195940ENST00000299252+45150_230130.0322.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69230529chr12:63195940ENST00000348801+13150_2300.0266.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69230529chr12:63195940ENST00000356290+56150_230130.0322.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69230529chr12:63195940ENST00000360430+34150_230105.0297.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69230529chr12:63195940ENST00000393412+13150_2300219.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69230529chr12:63195940ENST00000393413+12150_2300.0219.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69230529chr12:63195940ENST00000428863+14150_2300271.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69230529chr12:63195940ENST00000540827+45150_230105.0297.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69230529chr12:63195940ENST00000299252+45223_232130.0322.0USP7
HgeneMDM2chr12:69230529chr12:63195940ENST00000348801+13223_2320.0266.0USP7
HgeneMDM2chr12:69230529chr12:63195940ENST00000356290+56223_232130.0322.0USP7
HgeneMDM2chr12:69230529chr12:63195940ENST00000360430+34223_232105.0297.0USP7
HgeneMDM2chr12:69230529chr12:63195940ENST00000393412+13223_2320219.0USP7
HgeneMDM2chr12:69230529chr12:63195940ENST00000393413+12223_2320.0219.0USP7
HgeneMDM2chr12:69230529chr12:63195940ENST00000428863+14223_2320271.0USP7
HgeneMDM2chr12:69230529chr12:63195940ENST00000540827+45223_232105.0297.0USP7


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MDM2-PPM1H


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MDM2-PPM1H


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource