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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MDM2-SPATS2 (FusionGDB2 ID:52421)

Fusion Gene Summary for MDM2-SPATS2

check button Fusion gene summary
Fusion gene informationFusion gene name: MDM2-SPATS2
Fusion gene ID: 52421
HgeneTgene
Gene symbol

MDM2

SPATS2

Gene ID

4193

65244

Gene nameMDM2 proto-oncogenespermatogenesis associated serine rich 2
SynonymsACTFS|HDMX|LSKB|hdm2Nbla00526|P59SCR|SCR59|SPATA10
Cytomap

12q15

12q13.12

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase Mdm2MDM2 oncogene, E3 ubiquitin protein ligaseMDM2 proto-oncogene, E3 ubiquitin protein ligaseMdm2, p53 E3 ubiquitin protein ligase homologMdm2, transformed 3T3 cell double minute 2, p53 binding proteindouble minute 2, humspermatogenesis-associated serine-rich protein 2putative protein product of Nbla00526serine-rich spermatocytes and round spermatid 59 kDa proteinserine-rich spermatocytes and round spermatid protein
Modification date2020032920200315
UniProtAcc.

SPATS2L

Ensembl transtripts involved in fusion geneENST00000478070, ENST00000545204, 
ENST00000258148, ENST00000258149, 
ENST00000299252, ENST00000348801, 
ENST00000350057, ENST00000356290, 
ENST00000360430, ENST00000393410, 
ENST00000393412, ENST00000393413, 
ENST00000428863, ENST00000462284, 
ENST00000517852, ENST00000540827, 
ENST00000544125, ENST00000544561, 
ENST00000321898, ENST00000552918, 
ENST00000553127, ENST00000547865, 
ENST00000552557, 
Fusion gene scores* DoF score39 X 20 X 11=858012 X 14 X 7=1176
# samples 4715
** MAII scorelog2(47/8580*10)=-4.19024498582191
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1176*10)=-2.97085365434048
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MDM2 [Title/Abstract] AND SPATS2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMDM2(69233581)-SPATS2(49883248), # samples:1
Anticipated loss of major functional domain due to fusion event.MDM2-SPATS2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
MDM2-SPATS2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
MDM2-SPATS2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMDM2

GO:0000122

negative regulation of transcription by RNA polymerase II

9271120|17310983

HgeneMDM2

GO:0006511

ubiquitin-dependent protein catabolic process

11278372|15314173|16173922|17310983

HgeneMDM2

GO:0016567

protein ubiquitination

9450543|15878855|19656744|20153724

HgeneMDM2

GO:0031648

protein destabilization

9529249|10360174|15314173

HgeneMDM2

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

11278372

HgeneMDM2

GO:0034504

protein localization to nucleus

10360174

HgeneMDM2

GO:0042176

regulation of protein catabolic process

9153395

HgeneMDM2

GO:0043518

negative regulation of DNA damage response, signal transduction by p53 class mediator

9529249|10360174

HgeneMDM2

GO:0045184

establishment of protein localization

10360174

HgeneMDM2

GO:0045892

negative regulation of transcription, DNA-templated

9271120

HgeneMDM2

GO:0065003

protein-containing complex assembly

10608892|12915590

HgeneMDM2

GO:0071157

negative regulation of cell cycle arrest

9529249

HgeneMDM2

GO:0071480

cellular response to gamma radiation

16213212

HgeneMDM2

GO:0072717

cellular response to actinomycin D

15314173

HgeneMDM2

GO:1901797

negative regulation of signal transduction by p53 class mediator

16173922


check buttonFusion gene breakpoints across MDM2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SPATS2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-RN-AAAQ-01AMDM2chr12

69233581

+SPATS2chr12

49883248

+


Top

Fusion Gene ORF analysis for MDM2-SPATS2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000478070ENST00000321898MDM2chr12

69233581

+SPATS2chr12

49883248

+
3UTR-3CDSENST00000478070ENST00000552918MDM2chr12

69233581

+SPATS2chr12

49883248

+
3UTR-3CDSENST00000478070ENST00000553127MDM2chr12

69233581

+SPATS2chr12

49883248

+
3UTR-3CDSENST00000545204ENST00000321898MDM2chr12

69233581

+SPATS2chr12

49883248

+
3UTR-3CDSENST00000545204ENST00000552918MDM2chr12

69233581

+SPATS2chr12

49883248

+
3UTR-3CDSENST00000545204ENST00000553127MDM2chr12

69233581

+SPATS2chr12

49883248

+
3UTR-intronENST00000478070ENST00000547865MDM2chr12

69233581

+SPATS2chr12

49883248

+
3UTR-intronENST00000478070ENST00000552557MDM2chr12

69233581

+SPATS2chr12

49883248

+
3UTR-intronENST00000545204ENST00000547865MDM2chr12

69233581

+SPATS2chr12

49883248

+
3UTR-intronENST00000545204ENST00000552557MDM2chr12

69233581

+SPATS2chr12

49883248

+
5CDS-intronENST00000258148ENST00000547865MDM2chr12

69233581

+SPATS2chr12

49883248

+
5CDS-intronENST00000258148ENST00000552557MDM2chr12

69233581

+SPATS2chr12

49883248

+
5CDS-intronENST00000258149ENST00000547865MDM2chr12

69233581

+SPATS2chr12

49883248

+
5CDS-intronENST00000258149ENST00000552557MDM2chr12

69233581

+SPATS2chr12

49883248

+
5CDS-intronENST00000299252ENST00000547865MDM2chr12

69233581

+SPATS2chr12

49883248

+
5CDS-intronENST00000299252ENST00000552557MDM2chr12

69233581

+SPATS2chr12

49883248

+
5CDS-intronENST00000348801ENST00000547865MDM2chr12

69233581

+SPATS2chr12

49883248

+
5CDS-intronENST00000348801ENST00000552557MDM2chr12

69233581

+SPATS2chr12

49883248

+
5CDS-intronENST00000350057ENST00000547865MDM2chr12

69233581

+SPATS2chr12

49883248

+
5CDS-intronENST00000350057ENST00000552557MDM2chr12

69233581

+SPATS2chr12

49883248

+
5CDS-intronENST00000356290ENST00000547865MDM2chr12

69233581

+SPATS2chr12

49883248

+
5CDS-intronENST00000356290ENST00000552557MDM2chr12

69233581

+SPATS2chr12

49883248

+
5CDS-intronENST00000360430ENST00000547865MDM2chr12

69233581

+SPATS2chr12

49883248

+
5CDS-intronENST00000360430ENST00000552557MDM2chr12

69233581

+SPATS2chr12

49883248

+
5CDS-intronENST00000393410ENST00000547865MDM2chr12

69233581

+SPATS2chr12

49883248

+
5CDS-intronENST00000393410ENST00000552557MDM2chr12

69233581

+SPATS2chr12

49883248

+
5CDS-intronENST00000393412ENST00000547865MDM2chr12

69233581

+SPATS2chr12

49883248

+
5CDS-intronENST00000393412ENST00000552557MDM2chr12

69233581

+SPATS2chr12

49883248

+
5CDS-intronENST00000393413ENST00000547865MDM2chr12

69233581

+SPATS2chr12

49883248

+
5CDS-intronENST00000393413ENST00000552557MDM2chr12

69233581

+SPATS2chr12

49883248

+
5CDS-intronENST00000428863ENST00000547865MDM2chr12

69233581

+SPATS2chr12

49883248

+
5CDS-intronENST00000428863ENST00000552557MDM2chr12

69233581

+SPATS2chr12

49883248

+
5CDS-intronENST00000462284ENST00000547865MDM2chr12

69233581

+SPATS2chr12

49883248

+
5CDS-intronENST00000462284ENST00000552557MDM2chr12

69233581

+SPATS2chr12

49883248

+
5CDS-intronENST00000517852ENST00000547865MDM2chr12

69233581

+SPATS2chr12

49883248

+
5CDS-intronENST00000517852ENST00000552557MDM2chr12

69233581

+SPATS2chr12

49883248

+
5CDS-intronENST00000540827ENST00000547865MDM2chr12

69233581

+SPATS2chr12

49883248

+
5CDS-intronENST00000540827ENST00000552557MDM2chr12

69233581

+SPATS2chr12

49883248

+
Frame-shiftENST00000258149ENST00000321898MDM2chr12

69233581

+SPATS2chr12

49883248

+
Frame-shiftENST00000258149ENST00000552918MDM2chr12

69233581

+SPATS2chr12

49883248

+
Frame-shiftENST00000258149ENST00000553127MDM2chr12

69233581

+SPATS2chr12

49883248

+
Frame-shiftENST00000356290ENST00000321898MDM2chr12

69233581

+SPATS2chr12

49883248

+
Frame-shiftENST00000356290ENST00000552918MDM2chr12

69233581

+SPATS2chr12

49883248

+
Frame-shiftENST00000356290ENST00000553127MDM2chr12

69233581

+SPATS2chr12

49883248

+
Frame-shiftENST00000428863ENST00000321898MDM2chr12

69233581

+SPATS2chr12

49883248

+
Frame-shiftENST00000428863ENST00000552918MDM2chr12

69233581

+SPATS2chr12

49883248

+
Frame-shiftENST00000428863ENST00000553127MDM2chr12

69233581

+SPATS2chr12

49883248

+
Frame-shiftENST00000462284ENST00000321898MDM2chr12

69233581

+SPATS2chr12

49883248

+
Frame-shiftENST00000462284ENST00000552918MDM2chr12

69233581

+SPATS2chr12

49883248

+
Frame-shiftENST00000462284ENST00000553127MDM2chr12

69233581

+SPATS2chr12

49883248

+
Frame-shiftENST00000540827ENST00000321898MDM2chr12

69233581

+SPATS2chr12

49883248

+
Frame-shiftENST00000540827ENST00000552918MDM2chr12

69233581

+SPATS2chr12

49883248

+
Frame-shiftENST00000540827ENST00000553127MDM2chr12

69233581

+SPATS2chr12

49883248

+
In-frameENST00000258148ENST00000321898MDM2chr12

69233581

+SPATS2chr12

49883248

+
In-frameENST00000258148ENST00000552918MDM2chr12

69233581

+SPATS2chr12

49883248

+
In-frameENST00000258148ENST00000553127MDM2chr12

69233581

+SPATS2chr12

49883248

+
In-frameENST00000299252ENST00000321898MDM2chr12

69233581

+SPATS2chr12

49883248

+
In-frameENST00000299252ENST00000552918MDM2chr12

69233581

+SPATS2chr12

49883248

+
In-frameENST00000299252ENST00000553127MDM2chr12

69233581

+SPATS2chr12

49883248

+
In-frameENST00000348801ENST00000321898MDM2chr12

69233581

+SPATS2chr12

49883248

+
In-frameENST00000348801ENST00000552918MDM2chr12

69233581

+SPATS2chr12

49883248

+
In-frameENST00000348801ENST00000553127MDM2chr12

69233581

+SPATS2chr12

49883248

+
In-frameENST00000350057ENST00000321898MDM2chr12

69233581

+SPATS2chr12

49883248

+
In-frameENST00000350057ENST00000552918MDM2chr12

69233581

+SPATS2chr12

49883248

+
In-frameENST00000350057ENST00000553127MDM2chr12

69233581

+SPATS2chr12

49883248

+
In-frameENST00000360430ENST00000321898MDM2chr12

69233581

+SPATS2chr12

49883248

+
In-frameENST00000360430ENST00000552918MDM2chr12

69233581

+SPATS2chr12

49883248

+
In-frameENST00000360430ENST00000553127MDM2chr12

69233581

+SPATS2chr12

49883248

+
In-frameENST00000393410ENST00000321898MDM2chr12

69233581

+SPATS2chr12

49883248

+
In-frameENST00000393410ENST00000552918MDM2chr12

69233581

+SPATS2chr12

49883248

+
In-frameENST00000393410ENST00000553127MDM2chr12

69233581

+SPATS2chr12

49883248

+
In-frameENST00000393412ENST00000321898MDM2chr12

69233581

+SPATS2chr12

49883248

+
In-frameENST00000393412ENST00000552918MDM2chr12

69233581

+SPATS2chr12

49883248

+
In-frameENST00000393412ENST00000553127MDM2chr12

69233581

+SPATS2chr12

49883248

+
In-frameENST00000393413ENST00000321898MDM2chr12

69233581

+SPATS2chr12

49883248

+
In-frameENST00000393413ENST00000552918MDM2chr12

69233581

+SPATS2chr12

49883248

+
In-frameENST00000393413ENST00000553127MDM2chr12

69233581

+SPATS2chr12

49883248

+
In-frameENST00000517852ENST00000321898MDM2chr12

69233581

+SPATS2chr12

49883248

+
In-frameENST00000517852ENST00000552918MDM2chr12

69233581

+SPATS2chr12

49883248

+
In-frameENST00000517852ENST00000553127MDM2chr12

69233581

+SPATS2chr12

49883248

+
intron-3CDSENST00000544125ENST00000321898MDM2chr12

69233581

+SPATS2chr12

49883248

+
intron-3CDSENST00000544125ENST00000552918MDM2chr12

69233581

+SPATS2chr12

49883248

+
intron-3CDSENST00000544125ENST00000553127MDM2chr12

69233581

+SPATS2chr12

49883248

+
intron-3CDSENST00000544561ENST00000321898MDM2chr12

69233581

+SPATS2chr12

49883248

+
intron-3CDSENST00000544561ENST00000552918MDM2chr12

69233581

+SPATS2chr12

49883248

+
intron-3CDSENST00000544561ENST00000553127MDM2chr12

69233581

+SPATS2chr12

49883248

+
intron-intronENST00000544125ENST00000547865MDM2chr12

69233581

+SPATS2chr12

49883248

+
intron-intronENST00000544125ENST00000552557MDM2chr12

69233581

+SPATS2chr12

49883248

+
intron-intronENST00000544561ENST00000547865MDM2chr12

69233581

+SPATS2chr12

49883248

+
intron-intronENST00000544561ENST00000552557MDM2chr12

69233581

+SPATS2chr12

49883248

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000393412MDM2chr1269233581+ENST00000553127SPATS2chr1249883248+33436436942175493
ENST00000393412MDM2chr1269233581+ENST00000321898SPATS2chr1249883248+33406436942175493
ENST00000393412MDM2chr1269233581+ENST00000552918SPATS2chr1249883248+31476436942175493
ENST00000258148MDM2chr1269233581+ENST00000553127SPATS2chr1249883248+35338338842365493
ENST00000258148MDM2chr1269233581+ENST00000321898SPATS2chr1249883248+35308338842365493
ENST00000258148MDM2chr1269233581+ENST00000552918SPATS2chr1249883248+33378338842365493
ENST00000393410MDM2chr1269233581+ENST00000553127SPATS2chr1249883248+29042042551736493
ENST00000393410MDM2chr1269233581+ENST00000321898SPATS2chr1249883248+29012042551736493
ENST00000393410MDM2chr1269233581+ENST00000552918SPATS2chr1249883248+27082042551736493
ENST00000393413MDM2chr1269233581+ENST00000553127SPATS2chr1249883248+28291291801661493
ENST00000393413MDM2chr1269233581+ENST00000321898SPATS2chr1249883248+28261291801661493
ENST00000393413MDM2chr1269233581+ENST00000552918SPATS2chr1249883248+26331291801661493
ENST00000517852MDM2chr1269233581+ENST00000553127SPATS2chr1249883248+29042042551736493
ENST00000517852MDM2chr1269233581+ENST00000321898SPATS2chr1249883248+29012042551736493
ENST00000517852MDM2chr1269233581+ENST00000552918SPATS2chr1249883248+27082042551736493
ENST00000350057MDM2chr1269233581+ENST00000553127SPATS2chr1249883248+35738739242405493
ENST00000350057MDM2chr1269233581+ENST00000321898SPATS2chr1249883248+35708739242405493
ENST00000350057MDM2chr1269233581+ENST00000552918SPATS2chr1249883248+33778739242405493
ENST00000360430MDM2chr1269233581+ENST00000553127SPATS2chr1249883248+30633634141895493
ENST00000360430MDM2chr1269233581+ENST00000321898SPATS2chr1249883248+30603634141895493
ENST00000360430MDM2chr1269233581+ENST00000552918SPATS2chr1249883248+28673634141895493
ENST00000299252MDM2chr1269233581+ENST00000553127SPATS2chr1249883248+31384384891970493
ENST00000299252MDM2chr1269233581+ENST00000321898SPATS2chr1249883248+31354384891970493
ENST00000299252MDM2chr1269233581+ENST00000552918SPATS2chr1249883248+29424384891970493
ENST00000348801MDM2chr1269233581+ENST00000553127SPATS2chr1249883248+29702703211802493
ENST00000348801MDM2chr1269233581+ENST00000321898SPATS2chr1249883248+29672703211802493
ENST00000348801MDM2chr1269233581+ENST00000552918SPATS2chr1249883248+27742703211802493

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000393412ENST00000553127MDM2chr1269233581+SPATS2chr1249883248+0.0011793440.9988206
ENST00000393412ENST00000321898MDM2chr1269233581+SPATS2chr1249883248+0.0011720230.998828
ENST00000393412ENST00000552918MDM2chr1269233581+SPATS2chr1249883248+0.0015065580.99849343
ENST00000258148ENST00000553127MDM2chr1269233581+SPATS2chr1249883248+0.0017335390.9982665
ENST00000258148ENST00000321898MDM2chr1269233581+SPATS2chr1249883248+0.0017259280.9982741
ENST00000258148ENST00000552918MDM2chr1269233581+SPATS2chr1249883248+0.0024232090.9975768
ENST00000393410ENST00000553127MDM2chr1269233581+SPATS2chr1249883248+0.0013627390.99863726
ENST00000393410ENST00000321898MDM2chr1269233581+SPATS2chr1249883248+0.0013345450.99866545
ENST00000393410ENST00000552918MDM2chr1269233581+SPATS2chr1249883248+0.0018320630.9981679
ENST00000393413ENST00000553127MDM2chr1269233581+SPATS2chr1249883248+0.0014938950.9985061
ENST00000393413ENST00000321898MDM2chr1269233581+SPATS2chr1249883248+0.0014720660.9985279
ENST00000393413ENST00000552918MDM2chr1269233581+SPATS2chr1249883248+0.002033230.99796677
ENST00000517852ENST00000553127MDM2chr1269233581+SPATS2chr1249883248+0.0013627390.99863726
ENST00000517852ENST00000321898MDM2chr1269233581+SPATS2chr1249883248+0.0013345450.99866545
ENST00000517852ENST00000552918MDM2chr1269233581+SPATS2chr1249883248+0.0018320630.9981679
ENST00000350057ENST00000553127MDM2chr1269233581+SPATS2chr1249883248+0.001803340.99819666
ENST00000350057ENST00000321898MDM2chr1269233581+SPATS2chr1249883248+0.0017831740.9982168
ENST00000350057ENST00000552918MDM2chr1269233581+SPATS2chr1249883248+0.002565740.9974343
ENST00000360430ENST00000553127MDM2chr1269233581+SPATS2chr1249883248+0.0019129160.99808717
ENST00000360430ENST00000321898MDM2chr1269233581+SPATS2chr1249883248+0.0019016510.9980983
ENST00000360430ENST00000552918MDM2chr1269233581+SPATS2chr1249883248+0.0029364570.9970636
ENST00000299252ENST00000553127MDM2chr1269233581+SPATS2chr1249883248+0.0017583670.99824166
ENST00000299252ENST00000321898MDM2chr1269233581+SPATS2chr1249883248+0.0017495820.9982504
ENST00000299252ENST00000552918MDM2chr1269233581+SPATS2chr1249883248+0.0025441330.9974559
ENST00000348801ENST00000553127MDM2chr1269233581+SPATS2chr1249883248+0.0019239110.9980761
ENST00000348801ENST00000321898MDM2chr1269233581+SPATS2chr1249883248+0.0019024620.9980976
ENST00000348801ENST00000552918MDM2chr1269233581+SPATS2chr1249883248+0.0029489410.997051

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Fusion Genomic Features for MDM2-SPATS2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MDM2-SPATS2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:69233581/chr12:49883248)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.SPATS2

SPATS2L

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.558

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSPATS2chr12:69233581chr12:49883248ENST00000321898213364_41435546.0Compositional biasNote=Ser-rich
TgeneSPATS2chr12:69233581chr12:49883248ENST0000032189821386_9735546.0Compositional biasNote=Poly-Lys
TgeneSPATS2chr12:69233581chr12:49883248ENST00000552918314364_41435546.0Compositional biasNote=Ser-rich
TgeneSPATS2chr12:69233581chr12:49883248ENST0000055291831486_9735546.0Compositional biasNote=Poly-Lys
TgeneSPATS2chr12:69233581chr12:49883248ENST00000553127415364_41435546.0Compositional biasNote=Ser-rich
TgeneSPATS2chr12:69233581chr12:49883248ENST0000055312741586_9735546.0Compositional biasNote=Poly-Lys

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMDM2chr12:69233581chr12:49883248ENST00000258149+19210_2150437.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69233581chr12:49883248ENST00000258149+19243_3010437.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69233581chr12:49883248ENST00000299252+15210_2150322.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69233581chr12:49883248ENST00000299252+15243_3010322.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69233581chr12:49883248ENST00000348801+13210_2150266.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69233581chr12:49883248ENST00000348801+13243_3010266.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69233581chr12:49883248ENST00000356290+16210_2150322.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69233581chr12:49883248ENST00000356290+16243_3010322.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69233581chr12:49883248ENST00000360430+14210_2150297.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69233581chr12:49883248ENST00000360430+14243_3010297.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69233581chr12:49883248ENST00000393412+13210_2150219.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69233581chr12:49883248ENST00000393412+13243_3010219.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69233581chr12:49883248ENST00000393413+12210_2150219.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69233581chr12:49883248ENST00000393413+12243_3010219.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69233581chr12:49883248ENST00000428863+14210_2150271.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69233581chr12:49883248ENST00000428863+14243_3010271.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69233581chr12:49883248ENST00000462284+111210_2150498.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69233581chr12:49883248ENST00000462284+111243_3010498.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69233581chr12:49883248ENST00000540827+15210_2150297.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69233581chr12:49883248ENST00000540827+15243_3010297.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69233581chr12:49883248ENST00000258149+1926_1090437.0DomainSWIB/MDM2
HgeneMDM2chr12:69233581chr12:49883248ENST00000299252+1526_1090322.0DomainSWIB/MDM2
HgeneMDM2chr12:69233581chr12:49883248ENST00000348801+1326_1090266.0DomainSWIB/MDM2
HgeneMDM2chr12:69233581chr12:49883248ENST00000356290+1626_1090322.0DomainSWIB/MDM2
HgeneMDM2chr12:69233581chr12:49883248ENST00000360430+1426_1090297.0DomainSWIB/MDM2
HgeneMDM2chr12:69233581chr12:49883248ENST00000393412+1326_1090219.0DomainSWIB/MDM2
HgeneMDM2chr12:69233581chr12:49883248ENST00000393413+1226_1090219.0DomainSWIB/MDM2
HgeneMDM2chr12:69233581chr12:49883248ENST00000428863+1426_1090271.0DomainSWIB/MDM2
HgeneMDM2chr12:69233581chr12:49883248ENST00000462284+11126_1090498.0DomainSWIB/MDM2
HgeneMDM2chr12:69233581chr12:49883248ENST00000540827+1526_1090297.0DomainSWIB/MDM2
HgeneMDM2chr12:69233581chr12:49883248ENST00000258149+19179_1850437.0MotifNuclear localization signal
HgeneMDM2chr12:69233581chr12:49883248ENST00000258149+19190_2020437.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69233581chr12:49883248ENST00000258149+19466_4730437.0MotifNucleolar localization signal
HgeneMDM2chr12:69233581chr12:49883248ENST00000299252+15179_1850322.0MotifNuclear localization signal
HgeneMDM2chr12:69233581chr12:49883248ENST00000299252+15190_2020322.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69233581chr12:49883248ENST00000299252+15466_4730322.0MotifNucleolar localization signal
HgeneMDM2chr12:69233581chr12:49883248ENST00000348801+13179_1850266.0MotifNuclear localization signal
HgeneMDM2chr12:69233581chr12:49883248ENST00000348801+13190_2020266.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69233581chr12:49883248ENST00000348801+13466_4730266.0MotifNucleolar localization signal
HgeneMDM2chr12:69233581chr12:49883248ENST00000356290+16179_1850322.0MotifNuclear localization signal
HgeneMDM2chr12:69233581chr12:49883248ENST00000356290+16190_2020322.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69233581chr12:49883248ENST00000356290+16466_4730322.0MotifNucleolar localization signal
HgeneMDM2chr12:69233581chr12:49883248ENST00000360430+14179_1850297.0MotifNuclear localization signal
HgeneMDM2chr12:69233581chr12:49883248ENST00000360430+14190_2020297.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69233581chr12:49883248ENST00000360430+14466_4730297.0MotifNucleolar localization signal
HgeneMDM2chr12:69233581chr12:49883248ENST00000393412+13179_1850219.0MotifNuclear localization signal
HgeneMDM2chr12:69233581chr12:49883248ENST00000393412+13190_2020219.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69233581chr12:49883248ENST00000393412+13466_4730219.0MotifNucleolar localization signal
HgeneMDM2chr12:69233581chr12:49883248ENST00000393413+12179_1850219.0MotifNuclear localization signal
HgeneMDM2chr12:69233581chr12:49883248ENST00000393413+12190_2020219.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69233581chr12:49883248ENST00000393413+12466_4730219.0MotifNucleolar localization signal
HgeneMDM2chr12:69233581chr12:49883248ENST00000428863+14179_1850271.0MotifNuclear localization signal
HgeneMDM2chr12:69233581chr12:49883248ENST00000428863+14190_2020271.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69233581chr12:49883248ENST00000428863+14466_4730271.0MotifNucleolar localization signal
HgeneMDM2chr12:69233581chr12:49883248ENST00000462284+111179_1850498.0MotifNuclear localization signal
HgeneMDM2chr12:69233581chr12:49883248ENST00000462284+111190_2020498.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69233581chr12:49883248ENST00000462284+111466_4730498.0MotifNucleolar localization signal
HgeneMDM2chr12:69233581chr12:49883248ENST00000540827+15179_1850297.0MotifNuclear localization signal
HgeneMDM2chr12:69233581chr12:49883248ENST00000540827+15190_2020297.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69233581chr12:49883248ENST00000540827+15466_4730297.0MotifNucleolar localization signal
HgeneMDM2chr12:69233581chr12:49883248ENST00000258149+191_1010437.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69233581chr12:49883248ENST00000258149+19210_3040437.0RegionNote=ARF-binding
HgeneMDM2chr12:69233581chr12:49883248ENST00000258149+19242_3310437.0RegionNote=Region II
HgeneMDM2chr12:69233581chr12:49883248ENST00000299252+151_1010322.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69233581chr12:49883248ENST00000299252+15210_3040322.0RegionNote=ARF-binding
HgeneMDM2chr12:69233581chr12:49883248ENST00000299252+15242_3310322.0RegionNote=Region II
HgeneMDM2chr12:69233581chr12:49883248ENST00000348801+131_1010266.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69233581chr12:49883248ENST00000348801+13210_3040266.0RegionNote=ARF-binding
HgeneMDM2chr12:69233581chr12:49883248ENST00000348801+13242_3310266.0RegionNote=Region II
HgeneMDM2chr12:69233581chr12:49883248ENST00000356290+161_1010322.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69233581chr12:49883248ENST00000356290+16210_3040322.0RegionNote=ARF-binding
HgeneMDM2chr12:69233581chr12:49883248ENST00000356290+16242_3310322.0RegionNote=Region II
HgeneMDM2chr12:69233581chr12:49883248ENST00000360430+141_1010297.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69233581chr12:49883248ENST00000360430+14210_3040297.0RegionNote=ARF-binding
HgeneMDM2chr12:69233581chr12:49883248ENST00000360430+14242_3310297.0RegionNote=Region II
HgeneMDM2chr12:69233581chr12:49883248ENST00000393412+131_1010219.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69233581chr12:49883248ENST00000393412+13210_3040219.0RegionNote=ARF-binding
HgeneMDM2chr12:69233581chr12:49883248ENST00000393412+13242_3310219.0RegionNote=Region II
HgeneMDM2chr12:69233581chr12:49883248ENST00000393413+121_1010219.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69233581chr12:49883248ENST00000393413+12210_3040219.0RegionNote=ARF-binding
HgeneMDM2chr12:69233581chr12:49883248ENST00000393413+12242_3310219.0RegionNote=Region II
HgeneMDM2chr12:69233581chr12:49883248ENST00000428863+141_1010271.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69233581chr12:49883248ENST00000428863+14210_3040271.0RegionNote=ARF-binding
HgeneMDM2chr12:69233581chr12:49883248ENST00000428863+14242_3310271.0RegionNote=Region II
HgeneMDM2chr12:69233581chr12:49883248ENST00000462284+1111_1010498.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69233581chr12:49883248ENST00000462284+111210_3040498.0RegionNote=ARF-binding
HgeneMDM2chr12:69233581chr12:49883248ENST00000462284+111242_3310498.0RegionNote=Region II
HgeneMDM2chr12:69233581chr12:49883248ENST00000540827+151_1010297.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69233581chr12:49883248ENST00000540827+15210_3040297.0RegionNote=ARF-binding
HgeneMDM2chr12:69233581chr12:49883248ENST00000540827+15242_3310297.0RegionNote=Region II
HgeneMDM2chr12:69233581chr12:49883248ENST00000258149+19299_3280437.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69233581chr12:49883248ENST00000258149+19438_4790437.0Zinc fingerRING-type
HgeneMDM2chr12:69233581chr12:49883248ENST00000299252+15299_3280322.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69233581chr12:49883248ENST00000299252+15438_4790322.0Zinc fingerRING-type
HgeneMDM2chr12:69233581chr12:49883248ENST00000348801+13299_3280266.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69233581chr12:49883248ENST00000348801+13438_4790266.0Zinc fingerRING-type
HgeneMDM2chr12:69233581chr12:49883248ENST00000356290+16299_3280322.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69233581chr12:49883248ENST00000356290+16438_4790322.0Zinc fingerRING-type
HgeneMDM2chr12:69233581chr12:49883248ENST00000360430+14299_3280297.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69233581chr12:49883248ENST00000360430+14438_4790297.0Zinc fingerRING-type
HgeneMDM2chr12:69233581chr12:49883248ENST00000393412+13299_3280219.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69233581chr12:49883248ENST00000393412+13438_4790219.0Zinc fingerRING-type
HgeneMDM2chr12:69233581chr12:49883248ENST00000393413+12299_3280219.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69233581chr12:49883248ENST00000393413+12438_4790219.0Zinc fingerRING-type
HgeneMDM2chr12:69233581chr12:49883248ENST00000428863+14299_3280271.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69233581chr12:49883248ENST00000428863+14438_4790271.0Zinc fingerRING-type
HgeneMDM2chr12:69233581chr12:49883248ENST00000462284+111299_3280498.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69233581chr12:49883248ENST00000462284+111438_4790498.0Zinc fingerRING-type
HgeneMDM2chr12:69233581chr12:49883248ENST00000540827+15299_3280297.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69233581chr12:49883248ENST00000540827+15438_4790297.0Zinc fingerRING-type


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Fusion Gene Sequence for MDM2-SPATS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>52421_52421_1_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000258148_SPATS2_chr12_49883248_ENST00000321898_length(transcript)=3530nt_BP=833nt
CGCGAAAACCCCGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTC
CAGCTTCGGAACAAGAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATACTA
TGAAAGAGGTTCTTTTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATG
ATCTTCTAGGAGATTTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAG
TCAATCAGCAGGAAGAAAATTCAGATGAATTATCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTGATG
AAAGCCTGGCTCTGTGTGTAATAAGGGAGATATGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGGATCTTG
ATGCTGGTGTAAGTGAACATTCAGGTGATTGGTTGGATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAATTTGAAGTTGAATCTCTCG
ACTCAGAAGATTATAGCCTTAGTGAAGAAGGACAAGAACTCTCAGATGAAGATGATGAGGTATATCAAGTTACTGTGTATCAGGCAGGGG
AGAGTGATACAGATTCATTTGAAGAAGATCCTGAAATTTCCTTAGCTGTATGTAGACAACCAATTCAAATGATTGTGCTAACTTATTTCC
CCTAGTTGACCTGTCTATAAGAGATAAATGCGGTACGTGCAATAGTTCCTAATAAGAGCAACAATGAAATTATCCTGGTTTTGCAGCACT
TTGATAACTGTGTGGACAAAACAGTACAAGCATTCATGGAAGGTAGTGCCAGTGAAGTACTCAAAGAATGGACAGTAACAGGCAAGAAAA
AGAACAAAAAGAAGAAAAACAAACCGAAACCTGCCGCAGAACCAAGTAACGGCATCCCAGATTCCAGTAAATCAGTTTCCATTCAAGAGG
AACAGTCTGCGCCTTCCTCAGAGAAAGGTGGTATGAATGGCTACCATGTCAATGGTGCCATCAATGACACTGAGTCTGTGGACTCACTCA
GTGAAGGTTTGGAGACACTTTCAATAGATGCCAGAGAATTGGAGGATCCCGAGTCTGCCATGCTAGATACGCTGGATAGAACAGGATCCA
TGCTGCAGAATGGTGTCTCTGATTTTGAGACCAAGTCTTTGACTATGCACTCTATTCACAATTCTCAACAACCCAGGAATGCTGCCAAAT
CTCTCTCAAGACCTACCACAGAAACTCAGTTTTCAAATATGGGGATGGAAGATGTTCCCCTCGCCACCAGTAAAAAGCTAAGTTCCAATA
TTGAAAAATCTGTAAAAGACCTCCAGCGCTGCACAGTGTCTCTTGCACGGTATCGAGTTGTAGTTAAAGAAGAGATGGATGCCTCCATTA
AGAAAATGAAACAAGCCTTTGCTGAATTGGAGAGCTGTTTAATGGATCGAGAAGTGGCGTTGCTTGCTGAAATGGACAAAGTGAAAGCTG
AAGCAATGGAAATTTTGCTCAGCCGACAAAAGAAGGCTGAACTTCTAAAGAAGATGACTCATGTGGCTGTTCAAATGTCAGAGCAGCAAT
TGGTTGAGCTCAGAGCTGATATCAAGCACTTTGTTAGTGAACGTAAATATGATGAGGATCTGGGACGAGTAGCCCGGTTCACCTGTGATG
TAGAGACCCTAAAGAAGAGCATTGATTCATTTGGACAAGTGTCTCATCCAAAGAACAGCTATTCGACCAGATCCCGATGTAGCTCAGTTA
CATCTGTGTCCTTGAGTAGCCCAAGTGATGCCTCTGCTGCTTCCTCTTCCACCTGTGCCTCTCCTCCCAGCCTTACAAGTGCTAACAAGA
AAAACTTTGCACCGGGAGAGACTCCTGCAGCCATAGCAAACTCCAGTGGCCAGCCCTACCAGCCACTTCGGGAGGTATTGCCAGGGAACA
GACGAGGAGGACAGGGCTATAGGCCACAAGGCCAAAAGTCCAATGACCCCATGAACCAAGGGCGGCATGACAGTATGGGTCGTTACAGAA
ACAGCTCGTGGTATTCATCTGGTTCCAGGTATCAGAGTGCTCCATCTCAGGCACCAGGAAACACCATTGAAAGAGGCCAGACTCACTCTG
CAGGGACCAATGGAACTGGAGTCAGCATGGAGCCCAGCCCTCCCACGCCTTCATTCAAAAAGGGGCTCCCCCAGCGCAAACCCAGGACCT
CTCAGACTGAAGCCGTGAACTCTTGAGAGAAAATCCAGTTGGCCTCTCTCCTCTATCCACACAATTCAACTTGATAACTGGACTTTAGGA
AACTTACAGTTAGATGTAATAACAAAAAGAAGTTTATGCGTATCACTTTTTGTGCCATTCTAAGTATTTTTGGTTTCTTGTCTCCTTATT
TCCTCTTTACCATTTTTGGAGGGGAAGCTATTTTTTTTCCTTGATCTTTCCCAGTGATATGGATTGAATCTGGTTGGTCATTTCCACCAG
GAATCAGAGGCAGCTGTTACCAGGTTTCGGCCTTCCAGTTGATCCCTCCACTGTCCAGGCTGTCTCAGGAGGAGGTGAATCAGAGCTAGT
CTGTCACCTTTCCAATCTAAGCCGAAGCCACAGGTGCCTGACAGGTTCCCTTCTAACAACTATTTGACCAAGAGAGGCAATCAGGGGGTT
GTATACTGCACTGGATTCGCCAGAGAAGGGAAAATTTAATTAGTGAAAAGGAAAGAACACTAGGAAACATTTGAGAACCTGCCTCTATCC
CAGAATGTGCTGGAGATTTGACACTCAAATCAGTGTTTAGTCTTCTGCTTGGCACCATAGCTTAACCTGCAGTTTCTTCAAAATGCCCAA
TGCCTTGTTTCCTATTACCTTAGATTGCAAACCAGTCTAGGGAAGTCTATGAGAAAGTAGCATTTAATTAAAGTTTAAAAAAAAAAAGGT
TGGGCGTTGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACTAGGTCAGGAGTTCAAGACCAGCCTGGCC
AACATGGTGAAACCCTGTCTGTACTAAAAATACAAAAATTAGCTGAGCATGGTGGCGTGTGCCTGTAATCTCAGCTACTCAGGAGGCTGA
GGCAGGAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTGGGAGACAGAGCAAGACT
CAGTCTCAAAAAAAAAAAAAAAAGCATTTTTCTGTTTTAATGTTTGGAGACTTTTTTTTTTGTTCTCTCCCTTTCCTGAACCCTATTCTG
ATCCTGAACCAAATTTATAGCAATATAATTAGTGTTAATCTAAGGCATTACTCATCAAAAAAATTGCTGCAGTCTTTACAGTTGAATAAA

>52421_52421_1_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000258148_SPATS2_chr12_49883248_ENST00000321898_length(amino acids)=493AA_BP=
MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE
SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK
KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ
MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL
TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER

--------------------------------------------------------------
>52421_52421_2_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000258148_SPATS2_chr12_49883248_ENST00000552918_length(transcript)=3337nt_BP=833nt
CGCGAAAACCCCGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTC
CAGCTTCGGAACAAGAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATACTA
TGAAAGAGGTTCTTTTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATG
ATCTTCTAGGAGATTTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAG
TCAATCAGCAGGAAGAAAATTCAGATGAATTATCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTGATG
AAAGCCTGGCTCTGTGTGTAATAAGGGAGATATGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGGATCTTG
ATGCTGGTGTAAGTGAACATTCAGGTGATTGGTTGGATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAATTTGAAGTTGAATCTCTCG
ACTCAGAAGATTATAGCCTTAGTGAAGAAGGACAAGAACTCTCAGATGAAGATGATGAGGTATATCAAGTTACTGTGTATCAGGCAGGGG
AGAGTGATACAGATTCATTTGAAGAAGATCCTGAAATTTCCTTAGCTGTATGTAGACAACCAATTCAAATGATTGTGCTAACTTATTTCC
CCTAGTTGACCTGTCTATAAGAGATAAATGCGGTACGTGCAATAGTTCCTAATAAGAGCAACAATGAAATTATCCTGGTTTTGCAGCACT
TTGATAACTGTGTGGACAAAACAGTACAAGCATTCATGGAAGGTAGTGCCAGTGAAGTACTCAAAGAATGGACAGTAACAGGCAAGAAAA
AGAACAAAAAGAAGAAAAACAAACCGAAACCTGCCGCAGAACCAAGTAACGGCATCCCAGATTCCAGTAAATCAGTTTCCATTCAAGAGG
AACAGTCTGCGCCTTCCTCAGAGAAAGGTGGTATGAATGGCTACCATGTCAATGGTGCCATCAATGACACTGAGTCTGTGGACTCACTCA
GTGAAGGTTTGGAGACACTTTCAATAGATGCCAGAGAATTGGAGGATCCCGAGTCTGCCATGCTAGATACGCTGGATAGAACAGGATCCA
TGCTGCAGAATGGTGTCTCTGATTTTGAGACCAAGTCTTTGACTATGCACTCTATTCACAATTCTCAACAACCCAGGAATGCTGCCAAAT
CTCTCTCAAGACCTACCACAGAAACTCAGTTTTCAAATATGGGGATGGAAGATGTTCCCCTCGCCACCAGTAAAAAGCTAAGTTCCAATA
TTGAAAAATCTGTAAAAGACCTCCAGCGCTGCACAGTGTCTCTTGCACGGTATCGAGTTGTAGTTAAAGAAGAGATGGATGCCTCCATTA
AGAAAATGAAACAAGCCTTTGCTGAATTGGAGAGCTGTTTAATGGATCGAGAAGTGGCGTTGCTTGCTGAAATGGACAAAGTGAAAGCTG
AAGCAATGGAAATTTTGCTCAGCCGACAAAAGAAGGCTGAACTTCTAAAGAAGATGACTCATGTGGCTGTTCAAATGTCAGAGCAGCAAT
TGGTTGAGCTCAGAGCTGATATCAAGCACTTTGTTAGTGAACGTAAATATGATGAGGATCTGGGACGAGTAGCCCGGTTCACCTGTGATG
TAGAGACCCTAAAGAAGAGCATTGATTCATTTGGACAAGTGTCTCATCCAAAGAACAGCTATTCGACCAGATCCCGATGTAGCTCAGTTA
CATCTGTGTCCTTGAGTAGCCCAAGTGATGCCTCTGCTGCTTCCTCTTCCACCTGTGCCTCTCCTCCCAGCCTTACAAGTGCTAACAAGA
AAAACTTTGCACCGGGAGAGACTCCTGCAGCCATAGCAAACTCCAGTGGCCAGCCCTACCAGCCACTTCGGGAGGTATTGCCAGGGAACA
GACGAGGAGGACAGGGCTATAGGCCACAAGGCCAAAAGTCCAATGACCCCATGAACCAAGGGCGGCATGACAGTATGGGTCGTTACAGAA
ACAGCTCGTGGTATTCATCTGGTTCCAGGTATCAGAGTGCTCCATCTCAGGCACCAGGAAACACCATTGAAAGAGGCCAGACTCACTCTG
CAGGGACCAATGGAACTGGAGTCAGCATGGAGCCCAGCCCTCCCACGCCTTCATTCAAAAAGGGGCTCCCCCAGCGCAAACCCAGGACCT
CTCAGACTGAAGCCGTGAACTCTTGAGAGAAAATCCAGTTGGCCTCTCTCCTCTATCCACACAATTCAACTTGATAACTGGACTTTAGGA
AACTTACAGTTAGATGTAATAACAAAAAGAAGTTTATGCGTATCACTTTTTGTGCCATTCTAAGTATTTTTGGTTTCTTGTCTCCTTATT
TCCTCTTTACCATTTTTGGAGGGGAAGCTATTTTTTTTCCTTGATCTTTCCCAGTGATATGGATTGAATCTGGTTGGTCATTTCCACCAG
GAATCAGAGGCAGCTGTTACCAGGTTTCGGCCTTCCAGTTGATCCCTCCACTGTCCAGGCTGTCTCAGGAGGAGGTGAATCAGAGCTAGT
CTGTCACCTTTCCAATCTAAGCCGAAGCCACAGGTGCCTGACAGGTTCCCTTCTAACAACTATTTGACCAAGAGAGGCAATCAGGGGGTT
GTATACTGCACTGGATTCGCCAGAGAAGGGAAAATTTAATTAGTGAAAAGGAAAGAACACTAGGAAACATTTGAGAACCTGCCTCTATCC
CAGAATGTGCTGGAGATTTGACACTCAAATCAGTGTTTAGTCTTCTGCTTGGCACCATAGCTTAACCTGCAGTTTCTTCAAAATGCCCAA
TGCCTTGTTTCCTATTACCTTAGATTGCAAACCAGTCTAGGGAAGTCTATGAGAAAGTAGCATTTAATTAAAGTTTAAAAAAAAAAAGGT
TGGGCGTTGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACTAGGTCAGGAGTTCAAGACCAGCCTGGCC
AACATGGTGAAACCCTGTCTGTACTAAAAATACAAAAATTAGCTGAGCATGGTGGCGTGTGCCTGTAATCTCAGCTACTCAGGAGGCTGA
GGCAGGAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTGGGAGACAGAGCAAGACT

>52421_52421_2_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000258148_SPATS2_chr12_49883248_ENST00000552918_length(amino acids)=493AA_BP=
MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE
SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK
KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ
MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL
TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER

--------------------------------------------------------------
>52421_52421_3_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000258148_SPATS2_chr12_49883248_ENST00000553127_length(transcript)=3533nt_BP=833nt
CGCGAAAACCCCGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTC
CAGCTTCGGAACAAGAGACCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATACTA
TGAAAGAGGTTCTTTTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATG
ATCTTCTAGGAGATTTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAG
TCAATCAGCAGGAAGAAAATTCAGATGAATTATCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTGATG
AAAGCCTGGCTCTGTGTGTAATAAGGGAGATATGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGGATCTTG
ATGCTGGTGTAAGTGAACATTCAGGTGATTGGTTGGATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAATTTGAAGTTGAATCTCTCG
ACTCAGAAGATTATAGCCTTAGTGAAGAAGGACAAGAACTCTCAGATGAAGATGATGAGGTATATCAAGTTACTGTGTATCAGGCAGGGG
AGAGTGATACAGATTCATTTGAAGAAGATCCTGAAATTTCCTTAGCTGTATGTAGACAACCAATTCAAATGATTGTGCTAACTTATTTCC
CCTAGTTGACCTGTCTATAAGAGATAAATGCGGTACGTGCAATAGTTCCTAATAAGAGCAACAATGAAATTATCCTGGTTTTGCAGCACT
TTGATAACTGTGTGGACAAAACAGTACAAGCATTCATGGAAGGTAGTGCCAGTGAAGTACTCAAAGAATGGACAGTAACAGGCAAGAAAA
AGAACAAAAAGAAGAAAAACAAACCGAAACCTGCCGCAGAACCAAGTAACGGCATCCCAGATTCCAGTAAATCAGTTTCCATTCAAGAGG
AACAGTCTGCGCCTTCCTCAGAGAAAGGTGGTATGAATGGCTACCATGTCAATGGTGCCATCAATGACACTGAGTCTGTGGACTCACTCA
GTGAAGGTTTGGAGACACTTTCAATAGATGCCAGAGAATTGGAGGATCCCGAGTCTGCCATGCTAGATACGCTGGATAGAACAGGATCCA
TGCTGCAGAATGGTGTCTCTGATTTTGAGACCAAGTCTTTGACTATGCACTCTATTCACAATTCTCAACAACCCAGGAATGCTGCCAAAT
CTCTCTCAAGACCTACCACAGAAACTCAGTTTTCAAATATGGGGATGGAAGATGTTCCCCTCGCCACCAGTAAAAAGCTAAGTTCCAATA
TTGAAAAATCTGTAAAAGACCTCCAGCGCTGCACAGTGTCTCTTGCACGGTATCGAGTTGTAGTTAAAGAAGAGATGGATGCCTCCATTA
AGAAAATGAAACAAGCCTTTGCTGAATTGGAGAGCTGTTTAATGGATCGAGAAGTGGCGTTGCTTGCTGAAATGGACAAAGTGAAAGCTG
AAGCAATGGAAATTTTGCTCAGCCGACAAAAGAAGGCTGAACTTCTAAAGAAGATGACTCATGTGGCTGTTCAAATGTCAGAGCAGCAAT
TGGTTGAGCTCAGAGCTGATATCAAGCACTTTGTTAGTGAACGTAAATATGATGAGGATCTGGGACGAGTAGCCCGGTTCACCTGTGATG
TAGAGACCCTAAAGAAGAGCATTGATTCATTTGGACAAGTGTCTCATCCAAAGAACAGCTATTCGACCAGATCCCGATGTAGCTCAGTTA
CATCTGTGTCCTTGAGTAGCCCAAGTGATGCCTCTGCTGCTTCCTCTTCCACCTGTGCCTCTCCTCCCAGCCTTACAAGTGCTAACAAGA
AAAACTTTGCACCGGGAGAGACTCCTGCAGCCATAGCAAACTCCAGTGGCCAGCCCTACCAGCCACTTCGGGAGGTATTGCCAGGGAACA
GACGAGGAGGACAGGGCTATAGGCCACAAGGCCAAAAGTCCAATGACCCCATGAACCAAGGGCGGCATGACAGTATGGGTCGTTACAGAA
ACAGCTCGTGGTATTCATCTGGTTCCAGGTATCAGAGTGCTCCATCTCAGGCACCAGGAAACACCATTGAAAGAGGCCAGACTCACTCTG
CAGGGACCAATGGAACTGGAGTCAGCATGGAGCCCAGCCCTCCCACGCCTTCATTCAAAAAGGGGCTCCCCCAGCGCAAACCCAGGACCT
CTCAGACTGAAGCCGTGAACTCTTGAGAGAAAATCCAGTTGGCCTCTCTCCTCTATCCACACAATTCAACTTGATAACTGGACTTTAGGA
AACTTACAGTTAGATGTAATAACAAAAAGAAGTTTATGCGTATCACTTTTTGTGCCATTCTAAGTATTTTTGGTTTCTTGTCTCCTTATT
TCCTCTTTACCATTTTTGGAGGGGAAGCTATTTTTTTTCCTTGATCTTTCCCAGTGATATGGATTGAATCTGGTTGGTCATTTCCACCAG
GAATCAGAGGCAGCTGTTACCAGGTTTCGGCCTTCCAGTTGATCCCTCCACTGTCCAGGCTGTCTCAGGAGGAGGTGAATCAGAGCTAGT
CTGTCACCTTTCCAATCTAAGCCGAAGCCACAGGTGCCTGACAGGTTCCCTTCTAACAACTATTTGACCAAGAGAGGCAATCAGGGGGTT
GTATACTGCACTGGATTCGCCAGAGAAGGGAAAATTTAATTAGTGAAAAGGAAAGAACACTAGGAAACATTTGAGAACCTGCCTCTATCC
CAGAATGTGCTGGAGATTTGACACTCAAATCAGTGTTTAGTCTTCTGCTTGGCACCATAGCTTAACCTGCAGTTTCTTCAAAATGCCCAA
TGCCTTGTTTCCTATTACCTTAGATTGCAAACCAGTCTAGGGAAGTCTATGAGAAAGTAGCATTTAATTAAAGTTTAAAAAAAAAAAGGT
TGGGCGTTGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACTAGGTCAGGAGTTCAAGACCAGCCTGGCC
AACATGGTGAAACCCTGTCTGTACTAAAAATACAAAAATTAGCTGAGCATGGTGGCGTGTGCCTGTAATCTCAGCTACTCAGGAGGCTGA
GGCAGGAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTGGGAGACAGAGCAAGACT
CAGTCTCAAAAAAAAAAAAAAAAGCATTTTTCTGTTTTAATGTTTGGAGACTTTTTTTTTTGTTCTCTCCCTTTCCTGAACCCTATTCTG
ATCCTGAACCAAATTTATAGCAATATAATTAGTGTTAATCTAAGGCATTACTCATCAAAAAAATTGCTGCAGTCTTTACAGTTGAATAAA

>52421_52421_3_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000258148_SPATS2_chr12_49883248_ENST00000553127_length(amino acids)=493AA_BP=
MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE
SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK
KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ
MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL
TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER

--------------------------------------------------------------
>52421_52421_4_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000299252_SPATS2_chr12_49883248_ENST00000321898_length(transcript)=3135nt_BP=438nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTAGACCA
AAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATACTATGAAAGAGGATCTTGATGCTGGTGTAAGTGAA
CATTCAGGTGATTGGTTGGATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAATTTGAAGTTGAATCTCTCGACTCAGAAGATTATAGC
CTTAGTGAAGAAGGACAAGAACTCTCAGATGAAGATGATGAGGTATATCAAGTTACTGTGTATCAGGCAGGGGAGAGTGATACAGATTCA
TTTGAAGAAGATCCTGAAATTTCCTTAGCTGTATGTAGACAACCAATTCAAATGATTGTGCTAACTTATTTCCCCTAGATAAATGCGGTA
CGTGCAATAGTTCCTAATAAGAGCAACAATGAAATTATCCTGGTTTTGCAGCACTTTGATAACTGTGTGGACAAAACAGTACAAGCATTC
ATGGAAGGTAGTGCCAGTGAAGTACTCAAAGAATGGACAGTAACAGGCAAGAAAAAGAACAAAAAGAAGAAAAACAAACCGAAACCTGCC
GCAGAACCAAGTAACGGCATCCCAGATTCCAGTAAATCAGTTTCCATTCAAGAGGAACAGTCTGCGCCTTCCTCAGAGAAAGGTGGTATG
AATGGCTACCATGTCAATGGTGCCATCAATGACACTGAGTCTGTGGACTCACTCAGTGAAGGTTTGGAGACACTTTCAATAGATGCCAGA
GAATTGGAGGATCCCGAGTCTGCCATGCTAGATACGCTGGATAGAACAGGATCCATGCTGCAGAATGGTGTCTCTGATTTTGAGACCAAG
TCTTTGACTATGCACTCTATTCACAATTCTCAACAACCCAGGAATGCTGCCAAATCTCTCTCAAGACCTACCACAGAAACTCAGTTTTCA
AATATGGGGATGGAAGATGTTCCCCTCGCCACCAGTAAAAAGCTAAGTTCCAATATTGAAAAATCTGTAAAAGACCTCCAGCGCTGCACA
GTGTCTCTTGCACGGTATCGAGTTGTAGTTAAAGAAGAGATGGATGCCTCCATTAAGAAAATGAAACAAGCCTTTGCTGAATTGGAGAGC
TGTTTAATGGATCGAGAAGTGGCGTTGCTTGCTGAAATGGACAAAGTGAAAGCTGAAGCAATGGAAATTTTGCTCAGCCGACAAAAGAAG
GCTGAACTTCTAAAGAAGATGACTCATGTGGCTGTTCAAATGTCAGAGCAGCAATTGGTTGAGCTCAGAGCTGATATCAAGCACTTTGTT
AGTGAACGTAAATATGATGAGGATCTGGGACGAGTAGCCCGGTTCACCTGTGATGTAGAGACCCTAAAGAAGAGCATTGATTCATTTGGA
CAAGTGTCTCATCCAAAGAACAGCTATTCGACCAGATCCCGATGTAGCTCAGTTACATCTGTGTCCTTGAGTAGCCCAAGTGATGCCTCT
GCTGCTTCCTCTTCCACCTGTGCCTCTCCTCCCAGCCTTACAAGTGCTAACAAGAAAAACTTTGCACCGGGAGAGACTCCTGCAGCCATA
GCAAACTCCAGTGGCCAGCCCTACCAGCCACTTCGGGAGGTATTGCCAGGGAACAGACGAGGAGGACAGGGCTATAGGCCACAAGGCCAA
AAGTCCAATGACCCCATGAACCAAGGGCGGCATGACAGTATGGGTCGTTACAGAAACAGCTCGTGGTATTCATCTGGTTCCAGGTATCAG
AGTGCTCCATCTCAGGCACCAGGAAACACCATTGAAAGAGGCCAGACTCACTCTGCAGGGACCAATGGAACTGGAGTCAGCATGGAGCCC
AGCCCTCCCACGCCTTCATTCAAAAAGGGGCTCCCCCAGCGCAAACCCAGGACCTCTCAGACTGAAGCCGTGAACTCTTGAGAGAAAATC
CAGTTGGCCTCTCTCCTCTATCCACACAATTCAACTTGATAACTGGACTTTAGGAAACTTACAGTTAGATGTAATAACAAAAAGAAGTTT
ATGCGTATCACTTTTTGTGCCATTCTAAGTATTTTTGGTTTCTTGTCTCCTTATTTCCTCTTTACCATTTTTGGAGGGGAAGCTATTTTT
TTTCCTTGATCTTTCCCAGTGATATGGATTGAATCTGGTTGGTCATTTCCACCAGGAATCAGAGGCAGCTGTTACCAGGTTTCGGCCTTC
CAGTTGATCCCTCCACTGTCCAGGCTGTCTCAGGAGGAGGTGAATCAGAGCTAGTCTGTCACCTTTCCAATCTAAGCCGAAGCCACAGGT
GCCTGACAGGTTCCCTTCTAACAACTATTTGACCAAGAGAGGCAATCAGGGGGTTGTATACTGCACTGGATTCGCCAGAGAAGGGAAAAT
TTAATTAGTGAAAAGGAAAGAACACTAGGAAACATTTGAGAACCTGCCTCTATCCCAGAATGTGCTGGAGATTTGACACTCAAATCAGTG
TTTAGTCTTCTGCTTGGCACCATAGCTTAACCTGCAGTTTCTTCAAAATGCCCAATGCCTTGTTTCCTATTACCTTAGATTGCAAACCAG
TCTAGGGAAGTCTATGAGAAAGTAGCATTTAATTAAAGTTTAAAAAAAAAAAGGTTGGGCGTTGTGGCTCATGCCTGTAATCCCAGCACT
TTGGGAGGCTGAGGCGGGTGGATCACTAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTGTACTAAAAATACAA
AAATTAGCTGAGCATGGTGGCGTGTGCCTGTAATCTCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCGGAGGC
TGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTGGGAGACAGAGCAAGACTCAGTCTCAAAAAAAAAAAAAAAAGCATTTTTCTGT
TTTAATGTTTGGAGACTTTTTTTTTTGTTCTCTCCCTTTCCTGAACCCTATTCTGATCCTGAACCAAATTTATAGCAATATAATTAGTGT

>52421_52421_4_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000299252_SPATS2_chr12_49883248_ENST00000321898_length(amino acids)=493AA_BP=
MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE
SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK
KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ
MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL
TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER

--------------------------------------------------------------
>52421_52421_5_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000299252_SPATS2_chr12_49883248_ENST00000552918_length(transcript)=2942nt_BP=438nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTAGACCA
AAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATACTATGAAAGAGGATCTTGATGCTGGTGTAAGTGAA
CATTCAGGTGATTGGTTGGATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAATTTGAAGTTGAATCTCTCGACTCAGAAGATTATAGC
CTTAGTGAAGAAGGACAAGAACTCTCAGATGAAGATGATGAGGTATATCAAGTTACTGTGTATCAGGCAGGGGAGAGTGATACAGATTCA
TTTGAAGAAGATCCTGAAATTTCCTTAGCTGTATGTAGACAACCAATTCAAATGATTGTGCTAACTTATTTCCCCTAGATAAATGCGGTA
CGTGCAATAGTTCCTAATAAGAGCAACAATGAAATTATCCTGGTTTTGCAGCACTTTGATAACTGTGTGGACAAAACAGTACAAGCATTC
ATGGAAGGTAGTGCCAGTGAAGTACTCAAAGAATGGACAGTAACAGGCAAGAAAAAGAACAAAAAGAAGAAAAACAAACCGAAACCTGCC
GCAGAACCAAGTAACGGCATCCCAGATTCCAGTAAATCAGTTTCCATTCAAGAGGAACAGTCTGCGCCTTCCTCAGAGAAAGGTGGTATG
AATGGCTACCATGTCAATGGTGCCATCAATGACACTGAGTCTGTGGACTCACTCAGTGAAGGTTTGGAGACACTTTCAATAGATGCCAGA
GAATTGGAGGATCCCGAGTCTGCCATGCTAGATACGCTGGATAGAACAGGATCCATGCTGCAGAATGGTGTCTCTGATTTTGAGACCAAG
TCTTTGACTATGCACTCTATTCACAATTCTCAACAACCCAGGAATGCTGCCAAATCTCTCTCAAGACCTACCACAGAAACTCAGTTTTCA
AATATGGGGATGGAAGATGTTCCCCTCGCCACCAGTAAAAAGCTAAGTTCCAATATTGAAAAATCTGTAAAAGACCTCCAGCGCTGCACA
GTGTCTCTTGCACGGTATCGAGTTGTAGTTAAAGAAGAGATGGATGCCTCCATTAAGAAAATGAAACAAGCCTTTGCTGAATTGGAGAGC
TGTTTAATGGATCGAGAAGTGGCGTTGCTTGCTGAAATGGACAAAGTGAAAGCTGAAGCAATGGAAATTTTGCTCAGCCGACAAAAGAAG
GCTGAACTTCTAAAGAAGATGACTCATGTGGCTGTTCAAATGTCAGAGCAGCAATTGGTTGAGCTCAGAGCTGATATCAAGCACTTTGTT
AGTGAACGTAAATATGATGAGGATCTGGGACGAGTAGCCCGGTTCACCTGTGATGTAGAGACCCTAAAGAAGAGCATTGATTCATTTGGA
CAAGTGTCTCATCCAAAGAACAGCTATTCGACCAGATCCCGATGTAGCTCAGTTACATCTGTGTCCTTGAGTAGCCCAAGTGATGCCTCT
GCTGCTTCCTCTTCCACCTGTGCCTCTCCTCCCAGCCTTACAAGTGCTAACAAGAAAAACTTTGCACCGGGAGAGACTCCTGCAGCCATA
GCAAACTCCAGTGGCCAGCCCTACCAGCCACTTCGGGAGGTATTGCCAGGGAACAGACGAGGAGGACAGGGCTATAGGCCACAAGGCCAA
AAGTCCAATGACCCCATGAACCAAGGGCGGCATGACAGTATGGGTCGTTACAGAAACAGCTCGTGGTATTCATCTGGTTCCAGGTATCAG
AGTGCTCCATCTCAGGCACCAGGAAACACCATTGAAAGAGGCCAGACTCACTCTGCAGGGACCAATGGAACTGGAGTCAGCATGGAGCCC
AGCCCTCCCACGCCTTCATTCAAAAAGGGGCTCCCCCAGCGCAAACCCAGGACCTCTCAGACTGAAGCCGTGAACTCTTGAGAGAAAATC
CAGTTGGCCTCTCTCCTCTATCCACACAATTCAACTTGATAACTGGACTTTAGGAAACTTACAGTTAGATGTAATAACAAAAAGAAGTTT
ATGCGTATCACTTTTTGTGCCATTCTAAGTATTTTTGGTTTCTTGTCTCCTTATTTCCTCTTTACCATTTTTGGAGGGGAAGCTATTTTT
TTTCCTTGATCTTTCCCAGTGATATGGATTGAATCTGGTTGGTCATTTCCACCAGGAATCAGAGGCAGCTGTTACCAGGTTTCGGCCTTC
CAGTTGATCCCTCCACTGTCCAGGCTGTCTCAGGAGGAGGTGAATCAGAGCTAGTCTGTCACCTTTCCAATCTAAGCCGAAGCCACAGGT
GCCTGACAGGTTCCCTTCTAACAACTATTTGACCAAGAGAGGCAATCAGGGGGTTGTATACTGCACTGGATTCGCCAGAGAAGGGAAAAT
TTAATTAGTGAAAAGGAAAGAACACTAGGAAACATTTGAGAACCTGCCTCTATCCCAGAATGTGCTGGAGATTTGACACTCAAATCAGTG
TTTAGTCTTCTGCTTGGCACCATAGCTTAACCTGCAGTTTCTTCAAAATGCCCAATGCCTTGTTTCCTATTACCTTAGATTGCAAACCAG
TCTAGGGAAGTCTATGAGAAAGTAGCATTTAATTAAAGTTTAAAAAAAAAAAGGTTGGGCGTTGTGGCTCATGCCTGTAATCCCAGCACT
TTGGGAGGCTGAGGCGGGTGGATCACTAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTGTACTAAAAATACAA
AAATTAGCTGAGCATGGTGGCGTGTGCCTGTAATCTCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCGGAGGC

>52421_52421_5_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000299252_SPATS2_chr12_49883248_ENST00000552918_length(amino acids)=493AA_BP=
MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE
SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK
KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ
MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL
TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER

--------------------------------------------------------------
>52421_52421_6_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000299252_SPATS2_chr12_49883248_ENST00000553127_length(transcript)=3138nt_BP=438nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTAGACCA
AAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATACTATGAAAGAGGATCTTGATGCTGGTGTAAGTGAA
CATTCAGGTGATTGGTTGGATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAATTTGAAGTTGAATCTCTCGACTCAGAAGATTATAGC
CTTAGTGAAGAAGGACAAGAACTCTCAGATGAAGATGATGAGGTATATCAAGTTACTGTGTATCAGGCAGGGGAGAGTGATACAGATTCA
TTTGAAGAAGATCCTGAAATTTCCTTAGCTGTATGTAGACAACCAATTCAAATGATTGTGCTAACTTATTTCCCCTAGATAAATGCGGTA
CGTGCAATAGTTCCTAATAAGAGCAACAATGAAATTATCCTGGTTTTGCAGCACTTTGATAACTGTGTGGACAAAACAGTACAAGCATTC
ATGGAAGGTAGTGCCAGTGAAGTACTCAAAGAATGGACAGTAACAGGCAAGAAAAAGAACAAAAAGAAGAAAAACAAACCGAAACCTGCC
GCAGAACCAAGTAACGGCATCCCAGATTCCAGTAAATCAGTTTCCATTCAAGAGGAACAGTCTGCGCCTTCCTCAGAGAAAGGTGGTATG
AATGGCTACCATGTCAATGGTGCCATCAATGACACTGAGTCTGTGGACTCACTCAGTGAAGGTTTGGAGACACTTTCAATAGATGCCAGA
GAATTGGAGGATCCCGAGTCTGCCATGCTAGATACGCTGGATAGAACAGGATCCATGCTGCAGAATGGTGTCTCTGATTTTGAGACCAAG
TCTTTGACTATGCACTCTATTCACAATTCTCAACAACCCAGGAATGCTGCCAAATCTCTCTCAAGACCTACCACAGAAACTCAGTTTTCA
AATATGGGGATGGAAGATGTTCCCCTCGCCACCAGTAAAAAGCTAAGTTCCAATATTGAAAAATCTGTAAAAGACCTCCAGCGCTGCACA
GTGTCTCTTGCACGGTATCGAGTTGTAGTTAAAGAAGAGATGGATGCCTCCATTAAGAAAATGAAACAAGCCTTTGCTGAATTGGAGAGC
TGTTTAATGGATCGAGAAGTGGCGTTGCTTGCTGAAATGGACAAAGTGAAAGCTGAAGCAATGGAAATTTTGCTCAGCCGACAAAAGAAG
GCTGAACTTCTAAAGAAGATGACTCATGTGGCTGTTCAAATGTCAGAGCAGCAATTGGTTGAGCTCAGAGCTGATATCAAGCACTTTGTT
AGTGAACGTAAATATGATGAGGATCTGGGACGAGTAGCCCGGTTCACCTGTGATGTAGAGACCCTAAAGAAGAGCATTGATTCATTTGGA
CAAGTGTCTCATCCAAAGAACAGCTATTCGACCAGATCCCGATGTAGCTCAGTTACATCTGTGTCCTTGAGTAGCCCAAGTGATGCCTCT
GCTGCTTCCTCTTCCACCTGTGCCTCTCCTCCCAGCCTTACAAGTGCTAACAAGAAAAACTTTGCACCGGGAGAGACTCCTGCAGCCATA
GCAAACTCCAGTGGCCAGCCCTACCAGCCACTTCGGGAGGTATTGCCAGGGAACAGACGAGGAGGACAGGGCTATAGGCCACAAGGCCAA
AAGTCCAATGACCCCATGAACCAAGGGCGGCATGACAGTATGGGTCGTTACAGAAACAGCTCGTGGTATTCATCTGGTTCCAGGTATCAG
AGTGCTCCATCTCAGGCACCAGGAAACACCATTGAAAGAGGCCAGACTCACTCTGCAGGGACCAATGGAACTGGAGTCAGCATGGAGCCC
AGCCCTCCCACGCCTTCATTCAAAAAGGGGCTCCCCCAGCGCAAACCCAGGACCTCTCAGACTGAAGCCGTGAACTCTTGAGAGAAAATC
CAGTTGGCCTCTCTCCTCTATCCACACAATTCAACTTGATAACTGGACTTTAGGAAACTTACAGTTAGATGTAATAACAAAAAGAAGTTT
ATGCGTATCACTTTTTGTGCCATTCTAAGTATTTTTGGTTTCTTGTCTCCTTATTTCCTCTTTACCATTTTTGGAGGGGAAGCTATTTTT
TTTCCTTGATCTTTCCCAGTGATATGGATTGAATCTGGTTGGTCATTTCCACCAGGAATCAGAGGCAGCTGTTACCAGGTTTCGGCCTTC
CAGTTGATCCCTCCACTGTCCAGGCTGTCTCAGGAGGAGGTGAATCAGAGCTAGTCTGTCACCTTTCCAATCTAAGCCGAAGCCACAGGT
GCCTGACAGGTTCCCTTCTAACAACTATTTGACCAAGAGAGGCAATCAGGGGGTTGTATACTGCACTGGATTCGCCAGAGAAGGGAAAAT
TTAATTAGTGAAAAGGAAAGAACACTAGGAAACATTTGAGAACCTGCCTCTATCCCAGAATGTGCTGGAGATTTGACACTCAAATCAGTG
TTTAGTCTTCTGCTTGGCACCATAGCTTAACCTGCAGTTTCTTCAAAATGCCCAATGCCTTGTTTCCTATTACCTTAGATTGCAAACCAG
TCTAGGGAAGTCTATGAGAAAGTAGCATTTAATTAAAGTTTAAAAAAAAAAAGGTTGGGCGTTGTGGCTCATGCCTGTAATCCCAGCACT
TTGGGAGGCTGAGGCGGGTGGATCACTAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTGTACTAAAAATACAA
AAATTAGCTGAGCATGGTGGCGTGTGCCTGTAATCTCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCGGAGGC
TGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTGGGAGACAGAGCAAGACTCAGTCTCAAAAAAAAAAAAAAAAGCATTTTTCTGT
TTTAATGTTTGGAGACTTTTTTTTTTGTTCTCTCCCTTTCCTGAACCCTATTCTGATCCTGAACCAAATTTATAGCAATATAATTAGTGT

>52421_52421_6_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000299252_SPATS2_chr12_49883248_ENST00000553127_length(amino acids)=493AA_BP=
MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE
SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK
KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ
MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL
TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER

--------------------------------------------------------------
>52421_52421_7_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000348801_SPATS2_chr12_49883248_ENST00000321898_length(transcript)=2967nt_BP=270nt
ATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGATCTTGATGCTGGTGTAAGTGAA
CATTCAGGTGATTGGTTGGATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAATTTGAAGTTGAATCTCTCGACTCAGAAGATTATAGC
CTTAGTGAAGAAGGACAAGAACTCTCAGATGAAGATGATGAGGTATGTAGACAACCAATTCAAATGATTGTGCTAACTTATTTCCCCTAG
ATAAATGCGGTACGTGCAATAGTTCCTAATAAGAGCAACAATGAAATTATCCTGGTTTTGCAGCACTTTGATAACTGTGTGGACAAAACA
GTACAAGCATTCATGGAAGGTAGTGCCAGTGAAGTACTCAAAGAATGGACAGTAACAGGCAAGAAAAAGAACAAAAAGAAGAAAAACAAA
CCGAAACCTGCCGCAGAACCAAGTAACGGCATCCCAGATTCCAGTAAATCAGTTTCCATTCAAGAGGAACAGTCTGCGCCTTCCTCAGAG
AAAGGTGGTATGAATGGCTACCATGTCAATGGTGCCATCAATGACACTGAGTCTGTGGACTCACTCAGTGAAGGTTTGGAGACACTTTCA
ATAGATGCCAGAGAATTGGAGGATCCCGAGTCTGCCATGCTAGATACGCTGGATAGAACAGGATCCATGCTGCAGAATGGTGTCTCTGAT
TTTGAGACCAAGTCTTTGACTATGCACTCTATTCACAATTCTCAACAACCCAGGAATGCTGCCAAATCTCTCTCAAGACCTACCACAGAA
ACTCAGTTTTCAAATATGGGGATGGAAGATGTTCCCCTCGCCACCAGTAAAAAGCTAAGTTCCAATATTGAAAAATCTGTAAAAGACCTC
CAGCGCTGCACAGTGTCTCTTGCACGGTATCGAGTTGTAGTTAAAGAAGAGATGGATGCCTCCATTAAGAAAATGAAACAAGCCTTTGCT
GAATTGGAGAGCTGTTTAATGGATCGAGAAGTGGCGTTGCTTGCTGAAATGGACAAAGTGAAAGCTGAAGCAATGGAAATTTTGCTCAGC
CGACAAAAGAAGGCTGAACTTCTAAAGAAGATGACTCATGTGGCTGTTCAAATGTCAGAGCAGCAATTGGTTGAGCTCAGAGCTGATATC
AAGCACTTTGTTAGTGAACGTAAATATGATGAGGATCTGGGACGAGTAGCCCGGTTCACCTGTGATGTAGAGACCCTAAAGAAGAGCATT
GATTCATTTGGACAAGTGTCTCATCCAAAGAACAGCTATTCGACCAGATCCCGATGTAGCTCAGTTACATCTGTGTCCTTGAGTAGCCCA
AGTGATGCCTCTGCTGCTTCCTCTTCCACCTGTGCCTCTCCTCCCAGCCTTACAAGTGCTAACAAGAAAAACTTTGCACCGGGAGAGACT
CCTGCAGCCATAGCAAACTCCAGTGGCCAGCCCTACCAGCCACTTCGGGAGGTATTGCCAGGGAACAGACGAGGAGGACAGGGCTATAGG
CCACAAGGCCAAAAGTCCAATGACCCCATGAACCAAGGGCGGCATGACAGTATGGGTCGTTACAGAAACAGCTCGTGGTATTCATCTGGT
TCCAGGTATCAGAGTGCTCCATCTCAGGCACCAGGAAACACCATTGAAAGAGGCCAGACTCACTCTGCAGGGACCAATGGAACTGGAGTC
AGCATGGAGCCCAGCCCTCCCACGCCTTCATTCAAAAAGGGGCTCCCCCAGCGCAAACCCAGGACCTCTCAGACTGAAGCCGTGAACTCT
TGAGAGAAAATCCAGTTGGCCTCTCTCCTCTATCCACACAATTCAACTTGATAACTGGACTTTAGGAAACTTACAGTTAGATGTAATAAC
AAAAAGAAGTTTATGCGTATCACTTTTTGTGCCATTCTAAGTATTTTTGGTTTCTTGTCTCCTTATTTCCTCTTTACCATTTTTGGAGGG
GAAGCTATTTTTTTTCCTTGATCTTTCCCAGTGATATGGATTGAATCTGGTTGGTCATTTCCACCAGGAATCAGAGGCAGCTGTTACCAG
GTTTCGGCCTTCCAGTTGATCCCTCCACTGTCCAGGCTGTCTCAGGAGGAGGTGAATCAGAGCTAGTCTGTCACCTTTCCAATCTAAGCC
GAAGCCACAGGTGCCTGACAGGTTCCCTTCTAACAACTATTTGACCAAGAGAGGCAATCAGGGGGTTGTATACTGCACTGGATTCGCCAG
AGAAGGGAAAATTTAATTAGTGAAAAGGAAAGAACACTAGGAAACATTTGAGAACCTGCCTCTATCCCAGAATGTGCTGGAGATTTGACA
CTCAAATCAGTGTTTAGTCTTCTGCTTGGCACCATAGCTTAACCTGCAGTTTCTTCAAAATGCCCAATGCCTTGTTTCCTATTACCTTAG
ATTGCAAACCAGTCTAGGGAAGTCTATGAGAAAGTAGCATTTAATTAAAGTTTAAAAAAAAAAAGGTTGGGCGTTGTGGCTCATGCCTGT
AATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACTAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTGTA
CTAAAAATACAAAAATTAGCTGAGCATGGTGGCGTGTGCCTGTAATCTCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCA
GGAGGCGGAGGCTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTGGGAGACAGAGCAAGACTCAGTCTCAAAAAAAAAAAAAAAA
GCATTTTTCTGTTTTAATGTTTGGAGACTTTTTTTTTTGTTCTCTCCCTTTCCTGAACCCTATTCTGATCCTGAACCAAATTTATAGCAA

>52421_52421_7_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000348801_SPATS2_chr12_49883248_ENST00000321898_length(amino acids)=493AA_BP=
MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE
SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK
KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ
MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL
TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER

--------------------------------------------------------------
>52421_52421_8_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000348801_SPATS2_chr12_49883248_ENST00000552918_length(transcript)=2774nt_BP=270nt
ATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGATCTTGATGCTGGTGTAAGTGAA
CATTCAGGTGATTGGTTGGATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAATTTGAAGTTGAATCTCTCGACTCAGAAGATTATAGC
CTTAGTGAAGAAGGACAAGAACTCTCAGATGAAGATGATGAGGTATGTAGACAACCAATTCAAATGATTGTGCTAACTTATTTCCCCTAG
ATAAATGCGGTACGTGCAATAGTTCCTAATAAGAGCAACAATGAAATTATCCTGGTTTTGCAGCACTTTGATAACTGTGTGGACAAAACA
GTACAAGCATTCATGGAAGGTAGTGCCAGTGAAGTACTCAAAGAATGGACAGTAACAGGCAAGAAAAAGAACAAAAAGAAGAAAAACAAA
CCGAAACCTGCCGCAGAACCAAGTAACGGCATCCCAGATTCCAGTAAATCAGTTTCCATTCAAGAGGAACAGTCTGCGCCTTCCTCAGAG
AAAGGTGGTATGAATGGCTACCATGTCAATGGTGCCATCAATGACACTGAGTCTGTGGACTCACTCAGTGAAGGTTTGGAGACACTTTCA
ATAGATGCCAGAGAATTGGAGGATCCCGAGTCTGCCATGCTAGATACGCTGGATAGAACAGGATCCATGCTGCAGAATGGTGTCTCTGAT
TTTGAGACCAAGTCTTTGACTATGCACTCTATTCACAATTCTCAACAACCCAGGAATGCTGCCAAATCTCTCTCAAGACCTACCACAGAA
ACTCAGTTTTCAAATATGGGGATGGAAGATGTTCCCCTCGCCACCAGTAAAAAGCTAAGTTCCAATATTGAAAAATCTGTAAAAGACCTC
CAGCGCTGCACAGTGTCTCTTGCACGGTATCGAGTTGTAGTTAAAGAAGAGATGGATGCCTCCATTAAGAAAATGAAACAAGCCTTTGCT
GAATTGGAGAGCTGTTTAATGGATCGAGAAGTGGCGTTGCTTGCTGAAATGGACAAAGTGAAAGCTGAAGCAATGGAAATTTTGCTCAGC
CGACAAAAGAAGGCTGAACTTCTAAAGAAGATGACTCATGTGGCTGTTCAAATGTCAGAGCAGCAATTGGTTGAGCTCAGAGCTGATATC
AAGCACTTTGTTAGTGAACGTAAATATGATGAGGATCTGGGACGAGTAGCCCGGTTCACCTGTGATGTAGAGACCCTAAAGAAGAGCATT
GATTCATTTGGACAAGTGTCTCATCCAAAGAACAGCTATTCGACCAGATCCCGATGTAGCTCAGTTACATCTGTGTCCTTGAGTAGCCCA
AGTGATGCCTCTGCTGCTTCCTCTTCCACCTGTGCCTCTCCTCCCAGCCTTACAAGTGCTAACAAGAAAAACTTTGCACCGGGAGAGACT
CCTGCAGCCATAGCAAACTCCAGTGGCCAGCCCTACCAGCCACTTCGGGAGGTATTGCCAGGGAACAGACGAGGAGGACAGGGCTATAGG
CCACAAGGCCAAAAGTCCAATGACCCCATGAACCAAGGGCGGCATGACAGTATGGGTCGTTACAGAAACAGCTCGTGGTATTCATCTGGT
TCCAGGTATCAGAGTGCTCCATCTCAGGCACCAGGAAACACCATTGAAAGAGGCCAGACTCACTCTGCAGGGACCAATGGAACTGGAGTC
AGCATGGAGCCCAGCCCTCCCACGCCTTCATTCAAAAAGGGGCTCCCCCAGCGCAAACCCAGGACCTCTCAGACTGAAGCCGTGAACTCT
TGAGAGAAAATCCAGTTGGCCTCTCTCCTCTATCCACACAATTCAACTTGATAACTGGACTTTAGGAAACTTACAGTTAGATGTAATAAC
AAAAAGAAGTTTATGCGTATCACTTTTTGTGCCATTCTAAGTATTTTTGGTTTCTTGTCTCCTTATTTCCTCTTTACCATTTTTGGAGGG
GAAGCTATTTTTTTTCCTTGATCTTTCCCAGTGATATGGATTGAATCTGGTTGGTCATTTCCACCAGGAATCAGAGGCAGCTGTTACCAG
GTTTCGGCCTTCCAGTTGATCCCTCCACTGTCCAGGCTGTCTCAGGAGGAGGTGAATCAGAGCTAGTCTGTCACCTTTCCAATCTAAGCC
GAAGCCACAGGTGCCTGACAGGTTCCCTTCTAACAACTATTTGACCAAGAGAGGCAATCAGGGGGTTGTATACTGCACTGGATTCGCCAG
AGAAGGGAAAATTTAATTAGTGAAAAGGAAAGAACACTAGGAAACATTTGAGAACCTGCCTCTATCCCAGAATGTGCTGGAGATTTGACA
CTCAAATCAGTGTTTAGTCTTCTGCTTGGCACCATAGCTTAACCTGCAGTTTCTTCAAAATGCCCAATGCCTTGTTTCCTATTACCTTAG
ATTGCAAACCAGTCTAGGGAAGTCTATGAGAAAGTAGCATTTAATTAAAGTTTAAAAAAAAAAAGGTTGGGCGTTGTGGCTCATGCCTGT
AATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACTAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTGTA
CTAAAAATACAAAAATTAGCTGAGCATGGTGGCGTGTGCCTGTAATCTCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCA

>52421_52421_8_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000348801_SPATS2_chr12_49883248_ENST00000552918_length(amino acids)=493AA_BP=
MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE
SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK
KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ
MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL
TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER

--------------------------------------------------------------
>52421_52421_9_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000348801_SPATS2_chr12_49883248_ENST00000553127_length(transcript)=2970nt_BP=270nt
ATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGATCTTGATGCTGGTGTAAGTGAA
CATTCAGGTGATTGGTTGGATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAATTTGAAGTTGAATCTCTCGACTCAGAAGATTATAGC
CTTAGTGAAGAAGGACAAGAACTCTCAGATGAAGATGATGAGGTATGTAGACAACCAATTCAAATGATTGTGCTAACTTATTTCCCCTAG
ATAAATGCGGTACGTGCAATAGTTCCTAATAAGAGCAACAATGAAATTATCCTGGTTTTGCAGCACTTTGATAACTGTGTGGACAAAACA
GTACAAGCATTCATGGAAGGTAGTGCCAGTGAAGTACTCAAAGAATGGACAGTAACAGGCAAGAAAAAGAACAAAAAGAAGAAAAACAAA
CCGAAACCTGCCGCAGAACCAAGTAACGGCATCCCAGATTCCAGTAAATCAGTTTCCATTCAAGAGGAACAGTCTGCGCCTTCCTCAGAG
AAAGGTGGTATGAATGGCTACCATGTCAATGGTGCCATCAATGACACTGAGTCTGTGGACTCACTCAGTGAAGGTTTGGAGACACTTTCA
ATAGATGCCAGAGAATTGGAGGATCCCGAGTCTGCCATGCTAGATACGCTGGATAGAACAGGATCCATGCTGCAGAATGGTGTCTCTGAT
TTTGAGACCAAGTCTTTGACTATGCACTCTATTCACAATTCTCAACAACCCAGGAATGCTGCCAAATCTCTCTCAAGACCTACCACAGAA
ACTCAGTTTTCAAATATGGGGATGGAAGATGTTCCCCTCGCCACCAGTAAAAAGCTAAGTTCCAATATTGAAAAATCTGTAAAAGACCTC
CAGCGCTGCACAGTGTCTCTTGCACGGTATCGAGTTGTAGTTAAAGAAGAGATGGATGCCTCCATTAAGAAAATGAAACAAGCCTTTGCT
GAATTGGAGAGCTGTTTAATGGATCGAGAAGTGGCGTTGCTTGCTGAAATGGACAAAGTGAAAGCTGAAGCAATGGAAATTTTGCTCAGC
CGACAAAAGAAGGCTGAACTTCTAAAGAAGATGACTCATGTGGCTGTTCAAATGTCAGAGCAGCAATTGGTTGAGCTCAGAGCTGATATC
AAGCACTTTGTTAGTGAACGTAAATATGATGAGGATCTGGGACGAGTAGCCCGGTTCACCTGTGATGTAGAGACCCTAAAGAAGAGCATT
GATTCATTTGGACAAGTGTCTCATCCAAAGAACAGCTATTCGACCAGATCCCGATGTAGCTCAGTTACATCTGTGTCCTTGAGTAGCCCA
AGTGATGCCTCTGCTGCTTCCTCTTCCACCTGTGCCTCTCCTCCCAGCCTTACAAGTGCTAACAAGAAAAACTTTGCACCGGGAGAGACT
CCTGCAGCCATAGCAAACTCCAGTGGCCAGCCCTACCAGCCACTTCGGGAGGTATTGCCAGGGAACAGACGAGGAGGACAGGGCTATAGG
CCACAAGGCCAAAAGTCCAATGACCCCATGAACCAAGGGCGGCATGACAGTATGGGTCGTTACAGAAACAGCTCGTGGTATTCATCTGGT
TCCAGGTATCAGAGTGCTCCATCTCAGGCACCAGGAAACACCATTGAAAGAGGCCAGACTCACTCTGCAGGGACCAATGGAACTGGAGTC
AGCATGGAGCCCAGCCCTCCCACGCCTTCATTCAAAAAGGGGCTCCCCCAGCGCAAACCCAGGACCTCTCAGACTGAAGCCGTGAACTCT
TGAGAGAAAATCCAGTTGGCCTCTCTCCTCTATCCACACAATTCAACTTGATAACTGGACTTTAGGAAACTTACAGTTAGATGTAATAAC
AAAAAGAAGTTTATGCGTATCACTTTTTGTGCCATTCTAAGTATTTTTGGTTTCTTGTCTCCTTATTTCCTCTTTACCATTTTTGGAGGG
GAAGCTATTTTTTTTCCTTGATCTTTCCCAGTGATATGGATTGAATCTGGTTGGTCATTTCCACCAGGAATCAGAGGCAGCTGTTACCAG
GTTTCGGCCTTCCAGTTGATCCCTCCACTGTCCAGGCTGTCTCAGGAGGAGGTGAATCAGAGCTAGTCTGTCACCTTTCCAATCTAAGCC
GAAGCCACAGGTGCCTGACAGGTTCCCTTCTAACAACTATTTGACCAAGAGAGGCAATCAGGGGGTTGTATACTGCACTGGATTCGCCAG
AGAAGGGAAAATTTAATTAGTGAAAAGGAAAGAACACTAGGAAACATTTGAGAACCTGCCTCTATCCCAGAATGTGCTGGAGATTTGACA
CTCAAATCAGTGTTTAGTCTTCTGCTTGGCACCATAGCTTAACCTGCAGTTTCTTCAAAATGCCCAATGCCTTGTTTCCTATTACCTTAG
ATTGCAAACCAGTCTAGGGAAGTCTATGAGAAAGTAGCATTTAATTAAAGTTTAAAAAAAAAAAGGTTGGGCGTTGTGGCTCATGCCTGT
AATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACTAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTGTA
CTAAAAATACAAAAATTAGCTGAGCATGGTGGCGTGTGCCTGTAATCTCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCA
GGAGGCGGAGGCTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTGGGAGACAGAGCAAGACTCAGTCTCAAAAAAAAAAAAAAAA
GCATTTTTCTGTTTTAATGTTTGGAGACTTTTTTTTTTGTTCTCTCCCTTTCCTGAACCCTATTCTGATCCTGAACCAAATTTATAGCAA
TATAATTAGTGTTAATCTAAGGCATTACTCATCAAAAAAATTGCTGCAGTCTTTACAGTTGAATAAATAAAAACAACTGCATAAATATGC

>52421_52421_9_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000348801_SPATS2_chr12_49883248_ENST00000553127_length(amino acids)=493AA_BP=
MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE
SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK
KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ
MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL
TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER

--------------------------------------------------------------
>52421_52421_10_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000350057_SPATS2_chr12_49883248_ENST00000321898_length(transcript)=3570nt_BP=873nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTCTTTTT
TATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATGATCTTCTAGGAGATTTG
TTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAGTCAATCAGCAGGAATCA
TCGGACTCAGGTACATCTGTGAGTGAGAACAGGTGTCACCTTGAAGGTGGGAGTGATCAAAAGGACCTTGTACAAGAGCTTCAGGAAGAG
AAACCTTCATCTTCACATTTGGTTTCTAGACCATCTACCTCATCTAGAAGGAGAGCAATTAGTGAGACAGAAGAAAATTCAGATGAATTA
TCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTGATGAAAGCCTGGCTCTGTGTGTAATAAGGGAGATA
TGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGGATCTTGATGCTGGTGTAAGTGAACATTCAGGTGATTGG
TTGGATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAATTTGAAGTTGAATCTCTCGACTCAGAAGATTATAGCCTTAGTGAAGAAGGA
CAAGAACTCTCAGATGAAGATGATGAGGTATATCAAGTTACTGTGTATCAGGCAGGGGAGAGTGATACAGATTCATTTGAAGAAGATCCT
GAAATTTCCTTAGCTGTATGTAGACAACCAATTCAAATGATTGTGCTAACTTATTTCCCCTAGATAAATGCGGTACGTGCAATAGTTCCT
AATAAGAGCAACAATGAAATTATCCTGGTTTTGCAGCACTTTGATAACTGTGTGGACAAAACAGTACAAGCATTCATGGAAGGTAGTGCC
AGTGAAGTACTCAAAGAATGGACAGTAACAGGCAAGAAAAAGAACAAAAAGAAGAAAAACAAACCGAAACCTGCCGCAGAACCAAGTAAC
GGCATCCCAGATTCCAGTAAATCAGTTTCCATTCAAGAGGAACAGTCTGCGCCTTCCTCAGAGAAAGGTGGTATGAATGGCTACCATGTC
AATGGTGCCATCAATGACACTGAGTCTGTGGACTCACTCAGTGAAGGTTTGGAGACACTTTCAATAGATGCCAGAGAATTGGAGGATCCC
GAGTCTGCCATGCTAGATACGCTGGATAGAACAGGATCCATGCTGCAGAATGGTGTCTCTGATTTTGAGACCAAGTCTTTGACTATGCAC
TCTATTCACAATTCTCAACAACCCAGGAATGCTGCCAAATCTCTCTCAAGACCTACCACAGAAACTCAGTTTTCAAATATGGGGATGGAA
GATGTTCCCCTCGCCACCAGTAAAAAGCTAAGTTCCAATATTGAAAAATCTGTAAAAGACCTCCAGCGCTGCACAGTGTCTCTTGCACGG
TATCGAGTTGTAGTTAAAGAAGAGATGGATGCCTCCATTAAGAAAATGAAACAAGCCTTTGCTGAATTGGAGAGCTGTTTAATGGATCGA
GAAGTGGCGTTGCTTGCTGAAATGGACAAAGTGAAAGCTGAAGCAATGGAAATTTTGCTCAGCCGACAAAAGAAGGCTGAACTTCTAAAG
AAGATGACTCATGTGGCTGTTCAAATGTCAGAGCAGCAATTGGTTGAGCTCAGAGCTGATATCAAGCACTTTGTTAGTGAACGTAAATAT
GATGAGGATCTGGGACGAGTAGCCCGGTTCACCTGTGATGTAGAGACCCTAAAGAAGAGCATTGATTCATTTGGACAAGTGTCTCATCCA
AAGAACAGCTATTCGACCAGATCCCGATGTAGCTCAGTTACATCTGTGTCCTTGAGTAGCCCAAGTGATGCCTCTGCTGCTTCCTCTTCC
ACCTGTGCCTCTCCTCCCAGCCTTACAAGTGCTAACAAGAAAAACTTTGCACCGGGAGAGACTCCTGCAGCCATAGCAAACTCCAGTGGC
CAGCCCTACCAGCCACTTCGGGAGGTATTGCCAGGGAACAGACGAGGAGGACAGGGCTATAGGCCACAAGGCCAAAAGTCCAATGACCCC
ATGAACCAAGGGCGGCATGACAGTATGGGTCGTTACAGAAACAGCTCGTGGTATTCATCTGGTTCCAGGTATCAGAGTGCTCCATCTCAG
GCACCAGGAAACACCATTGAAAGAGGCCAGACTCACTCTGCAGGGACCAATGGAACTGGAGTCAGCATGGAGCCCAGCCCTCCCACGCCT
TCATTCAAAAAGGGGCTCCCCCAGCGCAAACCCAGGACCTCTCAGACTGAAGCCGTGAACTCTTGAGAGAAAATCCAGTTGGCCTCTCTC
CTCTATCCACACAATTCAACTTGATAACTGGACTTTAGGAAACTTACAGTTAGATGTAATAACAAAAAGAAGTTTATGCGTATCACTTTT
TGTGCCATTCTAAGTATTTTTGGTTTCTTGTCTCCTTATTTCCTCTTTACCATTTTTGGAGGGGAAGCTATTTTTTTTCCTTGATCTTTC
CCAGTGATATGGATTGAATCTGGTTGGTCATTTCCACCAGGAATCAGAGGCAGCTGTTACCAGGTTTCGGCCTTCCAGTTGATCCCTCCA
CTGTCCAGGCTGTCTCAGGAGGAGGTGAATCAGAGCTAGTCTGTCACCTTTCCAATCTAAGCCGAAGCCACAGGTGCCTGACAGGTTCCC
TTCTAACAACTATTTGACCAAGAGAGGCAATCAGGGGGTTGTATACTGCACTGGATTCGCCAGAGAAGGGAAAATTTAATTAGTGAAAAG
GAAAGAACACTAGGAAACATTTGAGAACCTGCCTCTATCCCAGAATGTGCTGGAGATTTGACACTCAAATCAGTGTTTAGTCTTCTGCTT
GGCACCATAGCTTAACCTGCAGTTTCTTCAAAATGCCCAATGCCTTGTTTCCTATTACCTTAGATTGCAAACCAGTCTAGGGAAGTCTAT
GAGAAAGTAGCATTTAATTAAAGTTTAAAAAAAAAAAGGTTGGGCGTTGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGC
GGGTGGATCACTAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTGTACTAAAAATACAAAAATTAGCTGAGCAT
GGTGGCGTGTGCCTGTAATCTCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCTGAGA
TTGTGCCACTGCACTCCAGCCTGGGAGACAGAGCAAGACTCAGTCTCAAAAAAAAAAAAAAAAGCATTTTTCTGTTTTAATGTTTGGAGA
CTTTTTTTTTTGTTCTCTCCCTTTCCTGAACCCTATTCTGATCCTGAACCAAATTTATAGCAATATAATTAGTGTTAATCTAAGGCATTA

>52421_52421_10_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000350057_SPATS2_chr12_49883248_ENST00000321898_length(amino acids)=493AA_BP=
MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE
SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK
KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ
MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL
TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER

--------------------------------------------------------------
>52421_52421_11_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000350057_SPATS2_chr12_49883248_ENST00000552918_length(transcript)=3377nt_BP=873nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTCTTTTT
TATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATGATCTTCTAGGAGATTTG
TTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAGTCAATCAGCAGGAATCA
TCGGACTCAGGTACATCTGTGAGTGAGAACAGGTGTCACCTTGAAGGTGGGAGTGATCAAAAGGACCTTGTACAAGAGCTTCAGGAAGAG
AAACCTTCATCTTCACATTTGGTTTCTAGACCATCTACCTCATCTAGAAGGAGAGCAATTAGTGAGACAGAAGAAAATTCAGATGAATTA
TCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTGATGAAAGCCTGGCTCTGTGTGTAATAAGGGAGATA
TGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGGATCTTGATGCTGGTGTAAGTGAACATTCAGGTGATTGG
TTGGATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAATTTGAAGTTGAATCTCTCGACTCAGAAGATTATAGCCTTAGTGAAGAAGGA
CAAGAACTCTCAGATGAAGATGATGAGGTATATCAAGTTACTGTGTATCAGGCAGGGGAGAGTGATACAGATTCATTTGAAGAAGATCCT
GAAATTTCCTTAGCTGTATGTAGACAACCAATTCAAATGATTGTGCTAACTTATTTCCCCTAGATAAATGCGGTACGTGCAATAGTTCCT
AATAAGAGCAACAATGAAATTATCCTGGTTTTGCAGCACTTTGATAACTGTGTGGACAAAACAGTACAAGCATTCATGGAAGGTAGTGCC
AGTGAAGTACTCAAAGAATGGACAGTAACAGGCAAGAAAAAGAACAAAAAGAAGAAAAACAAACCGAAACCTGCCGCAGAACCAAGTAAC
GGCATCCCAGATTCCAGTAAATCAGTTTCCATTCAAGAGGAACAGTCTGCGCCTTCCTCAGAGAAAGGTGGTATGAATGGCTACCATGTC
AATGGTGCCATCAATGACACTGAGTCTGTGGACTCACTCAGTGAAGGTTTGGAGACACTTTCAATAGATGCCAGAGAATTGGAGGATCCC
GAGTCTGCCATGCTAGATACGCTGGATAGAACAGGATCCATGCTGCAGAATGGTGTCTCTGATTTTGAGACCAAGTCTTTGACTATGCAC
TCTATTCACAATTCTCAACAACCCAGGAATGCTGCCAAATCTCTCTCAAGACCTACCACAGAAACTCAGTTTTCAAATATGGGGATGGAA
GATGTTCCCCTCGCCACCAGTAAAAAGCTAAGTTCCAATATTGAAAAATCTGTAAAAGACCTCCAGCGCTGCACAGTGTCTCTTGCACGG
TATCGAGTTGTAGTTAAAGAAGAGATGGATGCCTCCATTAAGAAAATGAAACAAGCCTTTGCTGAATTGGAGAGCTGTTTAATGGATCGA
GAAGTGGCGTTGCTTGCTGAAATGGACAAAGTGAAAGCTGAAGCAATGGAAATTTTGCTCAGCCGACAAAAGAAGGCTGAACTTCTAAAG
AAGATGACTCATGTGGCTGTTCAAATGTCAGAGCAGCAATTGGTTGAGCTCAGAGCTGATATCAAGCACTTTGTTAGTGAACGTAAATAT
GATGAGGATCTGGGACGAGTAGCCCGGTTCACCTGTGATGTAGAGACCCTAAAGAAGAGCATTGATTCATTTGGACAAGTGTCTCATCCA
AAGAACAGCTATTCGACCAGATCCCGATGTAGCTCAGTTACATCTGTGTCCTTGAGTAGCCCAAGTGATGCCTCTGCTGCTTCCTCTTCC
ACCTGTGCCTCTCCTCCCAGCCTTACAAGTGCTAACAAGAAAAACTTTGCACCGGGAGAGACTCCTGCAGCCATAGCAAACTCCAGTGGC
CAGCCCTACCAGCCACTTCGGGAGGTATTGCCAGGGAACAGACGAGGAGGACAGGGCTATAGGCCACAAGGCCAAAAGTCCAATGACCCC
ATGAACCAAGGGCGGCATGACAGTATGGGTCGTTACAGAAACAGCTCGTGGTATTCATCTGGTTCCAGGTATCAGAGTGCTCCATCTCAG
GCACCAGGAAACACCATTGAAAGAGGCCAGACTCACTCTGCAGGGACCAATGGAACTGGAGTCAGCATGGAGCCCAGCCCTCCCACGCCT
TCATTCAAAAAGGGGCTCCCCCAGCGCAAACCCAGGACCTCTCAGACTGAAGCCGTGAACTCTTGAGAGAAAATCCAGTTGGCCTCTCTC
CTCTATCCACACAATTCAACTTGATAACTGGACTTTAGGAAACTTACAGTTAGATGTAATAACAAAAAGAAGTTTATGCGTATCACTTTT
TGTGCCATTCTAAGTATTTTTGGTTTCTTGTCTCCTTATTTCCTCTTTACCATTTTTGGAGGGGAAGCTATTTTTTTTCCTTGATCTTTC
CCAGTGATATGGATTGAATCTGGTTGGTCATTTCCACCAGGAATCAGAGGCAGCTGTTACCAGGTTTCGGCCTTCCAGTTGATCCCTCCA
CTGTCCAGGCTGTCTCAGGAGGAGGTGAATCAGAGCTAGTCTGTCACCTTTCCAATCTAAGCCGAAGCCACAGGTGCCTGACAGGTTCCC
TTCTAACAACTATTTGACCAAGAGAGGCAATCAGGGGGTTGTATACTGCACTGGATTCGCCAGAGAAGGGAAAATTTAATTAGTGAAAAG
GAAAGAACACTAGGAAACATTTGAGAACCTGCCTCTATCCCAGAATGTGCTGGAGATTTGACACTCAAATCAGTGTTTAGTCTTCTGCTT
GGCACCATAGCTTAACCTGCAGTTTCTTCAAAATGCCCAATGCCTTGTTTCCTATTACCTTAGATTGCAAACCAGTCTAGGGAAGTCTAT
GAGAAAGTAGCATTTAATTAAAGTTTAAAAAAAAAAAGGTTGGGCGTTGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGC
GGGTGGATCACTAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTGTACTAAAAATACAAAAATTAGCTGAGCAT
GGTGGCGTGTGCCTGTAATCTCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCTGAGA

>52421_52421_11_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000350057_SPATS2_chr12_49883248_ENST00000552918_length(amino acids)=493AA_BP=
MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE
SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK
KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ
MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL
TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER

--------------------------------------------------------------
>52421_52421_12_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000350057_SPATS2_chr12_49883248_ENST00000553127_length(transcript)=3573nt_BP=873nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTCTTTTT
TATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATGATCTTCTAGGAGATTTG
TTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAGTCAATCAGCAGGAATCA
TCGGACTCAGGTACATCTGTGAGTGAGAACAGGTGTCACCTTGAAGGTGGGAGTGATCAAAAGGACCTTGTACAAGAGCTTCAGGAAGAG
AAACCTTCATCTTCACATTTGGTTTCTAGACCATCTACCTCATCTAGAAGGAGAGCAATTAGTGAGACAGAAGAAAATTCAGATGAATTA
TCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTGATGAAAGCCTGGCTCTGTGTGTAATAAGGGAGATA
TGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGGATCTTGATGCTGGTGTAAGTGAACATTCAGGTGATTGG
TTGGATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAATTTGAAGTTGAATCTCTCGACTCAGAAGATTATAGCCTTAGTGAAGAAGGA
CAAGAACTCTCAGATGAAGATGATGAGGTATATCAAGTTACTGTGTATCAGGCAGGGGAGAGTGATACAGATTCATTTGAAGAAGATCCT
GAAATTTCCTTAGCTGTATGTAGACAACCAATTCAAATGATTGTGCTAACTTATTTCCCCTAGATAAATGCGGTACGTGCAATAGTTCCT
AATAAGAGCAACAATGAAATTATCCTGGTTTTGCAGCACTTTGATAACTGTGTGGACAAAACAGTACAAGCATTCATGGAAGGTAGTGCC
AGTGAAGTACTCAAAGAATGGACAGTAACAGGCAAGAAAAAGAACAAAAAGAAGAAAAACAAACCGAAACCTGCCGCAGAACCAAGTAAC
GGCATCCCAGATTCCAGTAAATCAGTTTCCATTCAAGAGGAACAGTCTGCGCCTTCCTCAGAGAAAGGTGGTATGAATGGCTACCATGTC
AATGGTGCCATCAATGACACTGAGTCTGTGGACTCACTCAGTGAAGGTTTGGAGACACTTTCAATAGATGCCAGAGAATTGGAGGATCCC
GAGTCTGCCATGCTAGATACGCTGGATAGAACAGGATCCATGCTGCAGAATGGTGTCTCTGATTTTGAGACCAAGTCTTTGACTATGCAC
TCTATTCACAATTCTCAACAACCCAGGAATGCTGCCAAATCTCTCTCAAGACCTACCACAGAAACTCAGTTTTCAAATATGGGGATGGAA
GATGTTCCCCTCGCCACCAGTAAAAAGCTAAGTTCCAATATTGAAAAATCTGTAAAAGACCTCCAGCGCTGCACAGTGTCTCTTGCACGG
TATCGAGTTGTAGTTAAAGAAGAGATGGATGCCTCCATTAAGAAAATGAAACAAGCCTTTGCTGAATTGGAGAGCTGTTTAATGGATCGA
GAAGTGGCGTTGCTTGCTGAAATGGACAAAGTGAAAGCTGAAGCAATGGAAATTTTGCTCAGCCGACAAAAGAAGGCTGAACTTCTAAAG
AAGATGACTCATGTGGCTGTTCAAATGTCAGAGCAGCAATTGGTTGAGCTCAGAGCTGATATCAAGCACTTTGTTAGTGAACGTAAATAT
GATGAGGATCTGGGACGAGTAGCCCGGTTCACCTGTGATGTAGAGACCCTAAAGAAGAGCATTGATTCATTTGGACAAGTGTCTCATCCA
AAGAACAGCTATTCGACCAGATCCCGATGTAGCTCAGTTACATCTGTGTCCTTGAGTAGCCCAAGTGATGCCTCTGCTGCTTCCTCTTCC
ACCTGTGCCTCTCCTCCCAGCCTTACAAGTGCTAACAAGAAAAACTTTGCACCGGGAGAGACTCCTGCAGCCATAGCAAACTCCAGTGGC
CAGCCCTACCAGCCACTTCGGGAGGTATTGCCAGGGAACAGACGAGGAGGACAGGGCTATAGGCCACAAGGCCAAAAGTCCAATGACCCC
ATGAACCAAGGGCGGCATGACAGTATGGGTCGTTACAGAAACAGCTCGTGGTATTCATCTGGTTCCAGGTATCAGAGTGCTCCATCTCAG
GCACCAGGAAACACCATTGAAAGAGGCCAGACTCACTCTGCAGGGACCAATGGAACTGGAGTCAGCATGGAGCCCAGCCCTCCCACGCCT
TCATTCAAAAAGGGGCTCCCCCAGCGCAAACCCAGGACCTCTCAGACTGAAGCCGTGAACTCTTGAGAGAAAATCCAGTTGGCCTCTCTC
CTCTATCCACACAATTCAACTTGATAACTGGACTTTAGGAAACTTACAGTTAGATGTAATAACAAAAAGAAGTTTATGCGTATCACTTTT
TGTGCCATTCTAAGTATTTTTGGTTTCTTGTCTCCTTATTTCCTCTTTACCATTTTTGGAGGGGAAGCTATTTTTTTTCCTTGATCTTTC
CCAGTGATATGGATTGAATCTGGTTGGTCATTTCCACCAGGAATCAGAGGCAGCTGTTACCAGGTTTCGGCCTTCCAGTTGATCCCTCCA
CTGTCCAGGCTGTCTCAGGAGGAGGTGAATCAGAGCTAGTCTGTCACCTTTCCAATCTAAGCCGAAGCCACAGGTGCCTGACAGGTTCCC
TTCTAACAACTATTTGACCAAGAGAGGCAATCAGGGGGTTGTATACTGCACTGGATTCGCCAGAGAAGGGAAAATTTAATTAGTGAAAAG
GAAAGAACACTAGGAAACATTTGAGAACCTGCCTCTATCCCAGAATGTGCTGGAGATTTGACACTCAAATCAGTGTTTAGTCTTCTGCTT
GGCACCATAGCTTAACCTGCAGTTTCTTCAAAATGCCCAATGCCTTGTTTCCTATTACCTTAGATTGCAAACCAGTCTAGGGAAGTCTAT
GAGAAAGTAGCATTTAATTAAAGTTTAAAAAAAAAAAGGTTGGGCGTTGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGC
GGGTGGATCACTAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTGTACTAAAAATACAAAAATTAGCTGAGCAT
GGTGGCGTGTGCCTGTAATCTCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCTGAGA
TTGTGCCACTGCACTCCAGCCTGGGAGACAGAGCAAGACTCAGTCTCAAAAAAAAAAAAAAAAGCATTTTTCTGTTTTAATGTTTGGAGA
CTTTTTTTTTTGTTCTCTCCCTTTCCTGAACCCTATTCTGATCCTGAACCAAATTTATAGCAATATAATTAGTGTTAATCTAAGGCATTA

>52421_52421_12_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000350057_SPATS2_chr12_49883248_ENST00000553127_length(amino acids)=493AA_BP=
MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE
SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK
KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ
MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL
TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER

--------------------------------------------------------------
>52421_52421_13_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000360430_SPATS2_chr12_49883248_ENST00000321898_length(transcript)=3060nt_BP=363nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGATCTTGAT
GCTGGTGTAAGTGAACATTCAGGTGATTGGTTGGATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAATTTGAAGTTGAATCTCTCGAC
TCAGAAGATTATAGCCTTAGTGAAGAAGGACAAGAACTCTCAGATGAAGATGATGAGGTATATCAAGTTACTGTGTATCAGGCAGGGGAG
AGTGATACAGATTCATTTGAAGAAGATCCTGAAATTTCCTTAGCTGTATGTAGACAACCAATTCAAATGATTGTGCTAACTTATTTCCCC
TAGATAAATGCGGTACGTGCAATAGTTCCTAATAAGAGCAACAATGAAATTATCCTGGTTTTGCAGCACTTTGATAACTGTGTGGACAAA
ACAGTACAAGCATTCATGGAAGGTAGTGCCAGTGAAGTACTCAAAGAATGGACAGTAACAGGCAAGAAAAAGAACAAAAAGAAGAAAAAC
AAACCGAAACCTGCCGCAGAACCAAGTAACGGCATCCCAGATTCCAGTAAATCAGTTTCCATTCAAGAGGAACAGTCTGCGCCTTCCTCA
GAGAAAGGTGGTATGAATGGCTACCATGTCAATGGTGCCATCAATGACACTGAGTCTGTGGACTCACTCAGTGAAGGTTTGGAGACACTT
TCAATAGATGCCAGAGAATTGGAGGATCCCGAGTCTGCCATGCTAGATACGCTGGATAGAACAGGATCCATGCTGCAGAATGGTGTCTCT
GATTTTGAGACCAAGTCTTTGACTATGCACTCTATTCACAATTCTCAACAACCCAGGAATGCTGCCAAATCTCTCTCAAGACCTACCACA
GAAACTCAGTTTTCAAATATGGGGATGGAAGATGTTCCCCTCGCCACCAGTAAAAAGCTAAGTTCCAATATTGAAAAATCTGTAAAAGAC
CTCCAGCGCTGCACAGTGTCTCTTGCACGGTATCGAGTTGTAGTTAAAGAAGAGATGGATGCCTCCATTAAGAAAATGAAACAAGCCTTT
GCTGAATTGGAGAGCTGTTTAATGGATCGAGAAGTGGCGTTGCTTGCTGAAATGGACAAAGTGAAAGCTGAAGCAATGGAAATTTTGCTC
AGCCGACAAAAGAAGGCTGAACTTCTAAAGAAGATGACTCATGTGGCTGTTCAAATGTCAGAGCAGCAATTGGTTGAGCTCAGAGCTGAT
ATCAAGCACTTTGTTAGTGAACGTAAATATGATGAGGATCTGGGACGAGTAGCCCGGTTCACCTGTGATGTAGAGACCCTAAAGAAGAGC
ATTGATTCATTTGGACAAGTGTCTCATCCAAAGAACAGCTATTCGACCAGATCCCGATGTAGCTCAGTTACATCTGTGTCCTTGAGTAGC
CCAAGTGATGCCTCTGCTGCTTCCTCTTCCACCTGTGCCTCTCCTCCCAGCCTTACAAGTGCTAACAAGAAAAACTTTGCACCGGGAGAG
ACTCCTGCAGCCATAGCAAACTCCAGTGGCCAGCCCTACCAGCCACTTCGGGAGGTATTGCCAGGGAACAGACGAGGAGGACAGGGCTAT
AGGCCACAAGGCCAAAAGTCCAATGACCCCATGAACCAAGGGCGGCATGACAGTATGGGTCGTTACAGAAACAGCTCGTGGTATTCATCT
GGTTCCAGGTATCAGAGTGCTCCATCTCAGGCACCAGGAAACACCATTGAAAGAGGCCAGACTCACTCTGCAGGGACCAATGGAACTGGA
GTCAGCATGGAGCCCAGCCCTCCCACGCCTTCATTCAAAAAGGGGCTCCCCCAGCGCAAACCCAGGACCTCTCAGACTGAAGCCGTGAAC
TCTTGAGAGAAAATCCAGTTGGCCTCTCTCCTCTATCCACACAATTCAACTTGATAACTGGACTTTAGGAAACTTACAGTTAGATGTAAT
AACAAAAAGAAGTTTATGCGTATCACTTTTTGTGCCATTCTAAGTATTTTTGGTTTCTTGTCTCCTTATTTCCTCTTTACCATTTTTGGA
GGGGAAGCTATTTTTTTTCCTTGATCTTTCCCAGTGATATGGATTGAATCTGGTTGGTCATTTCCACCAGGAATCAGAGGCAGCTGTTAC
CAGGTTTCGGCCTTCCAGTTGATCCCTCCACTGTCCAGGCTGTCTCAGGAGGAGGTGAATCAGAGCTAGTCTGTCACCTTTCCAATCTAA
GCCGAAGCCACAGGTGCCTGACAGGTTCCCTTCTAACAACTATTTGACCAAGAGAGGCAATCAGGGGGTTGTATACTGCACTGGATTCGC
CAGAGAAGGGAAAATTTAATTAGTGAAAAGGAAAGAACACTAGGAAACATTTGAGAACCTGCCTCTATCCCAGAATGTGCTGGAGATTTG
ACACTCAAATCAGTGTTTAGTCTTCTGCTTGGCACCATAGCTTAACCTGCAGTTTCTTCAAAATGCCCAATGCCTTGTTTCCTATTACCT
TAGATTGCAAACCAGTCTAGGGAAGTCTATGAGAAAGTAGCATTTAATTAAAGTTTAAAAAAAAAAAGGTTGGGCGTTGTGGCTCATGCC
TGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACTAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCTGTCT
GTACTAAAAATACAAAAATTAGCTGAGCATGGTGGCGTGTGCCTGTAATCTCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAAC
CCAGGAGGCGGAGGCTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTGGGAGACAGAGCAAGACTCAGTCTCAAAAAAAAAAAAA
AAAGCATTTTTCTGTTTTAATGTTTGGAGACTTTTTTTTTTGTTCTCTCCCTTTCCTGAACCCTATTCTGATCCTGAACCAAATTTATAG
CAATATAATTAGTGTTAATCTAAGGCATTACTCATCAAAAAAATTGCTGCAGTCTTTACAGTTGAATAAATAAAAACAACTGCATAAATA

>52421_52421_13_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000360430_SPATS2_chr12_49883248_ENST00000321898_length(amino acids)=493AA_BP=
MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE
SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK
KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ
MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL
TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER

--------------------------------------------------------------
>52421_52421_14_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000360430_SPATS2_chr12_49883248_ENST00000552918_length(transcript)=2867nt_BP=363nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGATCTTGAT
GCTGGTGTAAGTGAACATTCAGGTGATTGGTTGGATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAATTTGAAGTTGAATCTCTCGAC
TCAGAAGATTATAGCCTTAGTGAAGAAGGACAAGAACTCTCAGATGAAGATGATGAGGTATATCAAGTTACTGTGTATCAGGCAGGGGAG
AGTGATACAGATTCATTTGAAGAAGATCCTGAAATTTCCTTAGCTGTATGTAGACAACCAATTCAAATGATTGTGCTAACTTATTTCCCC
TAGATAAATGCGGTACGTGCAATAGTTCCTAATAAGAGCAACAATGAAATTATCCTGGTTTTGCAGCACTTTGATAACTGTGTGGACAAA
ACAGTACAAGCATTCATGGAAGGTAGTGCCAGTGAAGTACTCAAAGAATGGACAGTAACAGGCAAGAAAAAGAACAAAAAGAAGAAAAAC
AAACCGAAACCTGCCGCAGAACCAAGTAACGGCATCCCAGATTCCAGTAAATCAGTTTCCATTCAAGAGGAACAGTCTGCGCCTTCCTCA
GAGAAAGGTGGTATGAATGGCTACCATGTCAATGGTGCCATCAATGACACTGAGTCTGTGGACTCACTCAGTGAAGGTTTGGAGACACTT
TCAATAGATGCCAGAGAATTGGAGGATCCCGAGTCTGCCATGCTAGATACGCTGGATAGAACAGGATCCATGCTGCAGAATGGTGTCTCT
GATTTTGAGACCAAGTCTTTGACTATGCACTCTATTCACAATTCTCAACAACCCAGGAATGCTGCCAAATCTCTCTCAAGACCTACCACA
GAAACTCAGTTTTCAAATATGGGGATGGAAGATGTTCCCCTCGCCACCAGTAAAAAGCTAAGTTCCAATATTGAAAAATCTGTAAAAGAC
CTCCAGCGCTGCACAGTGTCTCTTGCACGGTATCGAGTTGTAGTTAAAGAAGAGATGGATGCCTCCATTAAGAAAATGAAACAAGCCTTT
GCTGAATTGGAGAGCTGTTTAATGGATCGAGAAGTGGCGTTGCTTGCTGAAATGGACAAAGTGAAAGCTGAAGCAATGGAAATTTTGCTC
AGCCGACAAAAGAAGGCTGAACTTCTAAAGAAGATGACTCATGTGGCTGTTCAAATGTCAGAGCAGCAATTGGTTGAGCTCAGAGCTGAT
ATCAAGCACTTTGTTAGTGAACGTAAATATGATGAGGATCTGGGACGAGTAGCCCGGTTCACCTGTGATGTAGAGACCCTAAAGAAGAGC
ATTGATTCATTTGGACAAGTGTCTCATCCAAAGAACAGCTATTCGACCAGATCCCGATGTAGCTCAGTTACATCTGTGTCCTTGAGTAGC
CCAAGTGATGCCTCTGCTGCTTCCTCTTCCACCTGTGCCTCTCCTCCCAGCCTTACAAGTGCTAACAAGAAAAACTTTGCACCGGGAGAG
ACTCCTGCAGCCATAGCAAACTCCAGTGGCCAGCCCTACCAGCCACTTCGGGAGGTATTGCCAGGGAACAGACGAGGAGGACAGGGCTAT
AGGCCACAAGGCCAAAAGTCCAATGACCCCATGAACCAAGGGCGGCATGACAGTATGGGTCGTTACAGAAACAGCTCGTGGTATTCATCT
GGTTCCAGGTATCAGAGTGCTCCATCTCAGGCACCAGGAAACACCATTGAAAGAGGCCAGACTCACTCTGCAGGGACCAATGGAACTGGA
GTCAGCATGGAGCCCAGCCCTCCCACGCCTTCATTCAAAAAGGGGCTCCCCCAGCGCAAACCCAGGACCTCTCAGACTGAAGCCGTGAAC
TCTTGAGAGAAAATCCAGTTGGCCTCTCTCCTCTATCCACACAATTCAACTTGATAACTGGACTTTAGGAAACTTACAGTTAGATGTAAT
AACAAAAAGAAGTTTATGCGTATCACTTTTTGTGCCATTCTAAGTATTTTTGGTTTCTTGTCTCCTTATTTCCTCTTTACCATTTTTGGA
GGGGAAGCTATTTTTTTTCCTTGATCTTTCCCAGTGATATGGATTGAATCTGGTTGGTCATTTCCACCAGGAATCAGAGGCAGCTGTTAC
CAGGTTTCGGCCTTCCAGTTGATCCCTCCACTGTCCAGGCTGTCTCAGGAGGAGGTGAATCAGAGCTAGTCTGTCACCTTTCCAATCTAA
GCCGAAGCCACAGGTGCCTGACAGGTTCCCTTCTAACAACTATTTGACCAAGAGAGGCAATCAGGGGGTTGTATACTGCACTGGATTCGC
CAGAGAAGGGAAAATTTAATTAGTGAAAAGGAAAGAACACTAGGAAACATTTGAGAACCTGCCTCTATCCCAGAATGTGCTGGAGATTTG
ACACTCAAATCAGTGTTTAGTCTTCTGCTTGGCACCATAGCTTAACCTGCAGTTTCTTCAAAATGCCCAATGCCTTGTTTCCTATTACCT
TAGATTGCAAACCAGTCTAGGGAAGTCTATGAGAAAGTAGCATTTAATTAAAGTTTAAAAAAAAAAAGGTTGGGCGTTGTGGCTCATGCC
TGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACTAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCTGTCT
GTACTAAAAATACAAAAATTAGCTGAGCATGGTGGCGTGTGCCTGTAATCTCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAAC

>52421_52421_14_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000360430_SPATS2_chr12_49883248_ENST00000552918_length(amino acids)=493AA_BP=
MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE
SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK
KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ
MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL
TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER

--------------------------------------------------------------
>52421_52421_15_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000360430_SPATS2_chr12_49883248_ENST00000553127_length(transcript)=3063nt_BP=363nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGATCTTGAT
GCTGGTGTAAGTGAACATTCAGGTGATTGGTTGGATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAATTTGAAGTTGAATCTCTCGAC
TCAGAAGATTATAGCCTTAGTGAAGAAGGACAAGAACTCTCAGATGAAGATGATGAGGTATATCAAGTTACTGTGTATCAGGCAGGGGAG
AGTGATACAGATTCATTTGAAGAAGATCCTGAAATTTCCTTAGCTGTATGTAGACAACCAATTCAAATGATTGTGCTAACTTATTTCCCC
TAGATAAATGCGGTACGTGCAATAGTTCCTAATAAGAGCAACAATGAAATTATCCTGGTTTTGCAGCACTTTGATAACTGTGTGGACAAA
ACAGTACAAGCATTCATGGAAGGTAGTGCCAGTGAAGTACTCAAAGAATGGACAGTAACAGGCAAGAAAAAGAACAAAAAGAAGAAAAAC
AAACCGAAACCTGCCGCAGAACCAAGTAACGGCATCCCAGATTCCAGTAAATCAGTTTCCATTCAAGAGGAACAGTCTGCGCCTTCCTCA
GAGAAAGGTGGTATGAATGGCTACCATGTCAATGGTGCCATCAATGACACTGAGTCTGTGGACTCACTCAGTGAAGGTTTGGAGACACTT
TCAATAGATGCCAGAGAATTGGAGGATCCCGAGTCTGCCATGCTAGATACGCTGGATAGAACAGGATCCATGCTGCAGAATGGTGTCTCT
GATTTTGAGACCAAGTCTTTGACTATGCACTCTATTCACAATTCTCAACAACCCAGGAATGCTGCCAAATCTCTCTCAAGACCTACCACA
GAAACTCAGTTTTCAAATATGGGGATGGAAGATGTTCCCCTCGCCACCAGTAAAAAGCTAAGTTCCAATATTGAAAAATCTGTAAAAGAC
CTCCAGCGCTGCACAGTGTCTCTTGCACGGTATCGAGTTGTAGTTAAAGAAGAGATGGATGCCTCCATTAAGAAAATGAAACAAGCCTTT
GCTGAATTGGAGAGCTGTTTAATGGATCGAGAAGTGGCGTTGCTTGCTGAAATGGACAAAGTGAAAGCTGAAGCAATGGAAATTTTGCTC
AGCCGACAAAAGAAGGCTGAACTTCTAAAGAAGATGACTCATGTGGCTGTTCAAATGTCAGAGCAGCAATTGGTTGAGCTCAGAGCTGAT
ATCAAGCACTTTGTTAGTGAACGTAAATATGATGAGGATCTGGGACGAGTAGCCCGGTTCACCTGTGATGTAGAGACCCTAAAGAAGAGC
ATTGATTCATTTGGACAAGTGTCTCATCCAAAGAACAGCTATTCGACCAGATCCCGATGTAGCTCAGTTACATCTGTGTCCTTGAGTAGC
CCAAGTGATGCCTCTGCTGCTTCCTCTTCCACCTGTGCCTCTCCTCCCAGCCTTACAAGTGCTAACAAGAAAAACTTTGCACCGGGAGAG
ACTCCTGCAGCCATAGCAAACTCCAGTGGCCAGCCCTACCAGCCACTTCGGGAGGTATTGCCAGGGAACAGACGAGGAGGACAGGGCTAT
AGGCCACAAGGCCAAAAGTCCAATGACCCCATGAACCAAGGGCGGCATGACAGTATGGGTCGTTACAGAAACAGCTCGTGGTATTCATCT
GGTTCCAGGTATCAGAGTGCTCCATCTCAGGCACCAGGAAACACCATTGAAAGAGGCCAGACTCACTCTGCAGGGACCAATGGAACTGGA
GTCAGCATGGAGCCCAGCCCTCCCACGCCTTCATTCAAAAAGGGGCTCCCCCAGCGCAAACCCAGGACCTCTCAGACTGAAGCCGTGAAC
TCTTGAGAGAAAATCCAGTTGGCCTCTCTCCTCTATCCACACAATTCAACTTGATAACTGGACTTTAGGAAACTTACAGTTAGATGTAAT
AACAAAAAGAAGTTTATGCGTATCACTTTTTGTGCCATTCTAAGTATTTTTGGTTTCTTGTCTCCTTATTTCCTCTTTACCATTTTTGGA
GGGGAAGCTATTTTTTTTCCTTGATCTTTCCCAGTGATATGGATTGAATCTGGTTGGTCATTTCCACCAGGAATCAGAGGCAGCTGTTAC
CAGGTTTCGGCCTTCCAGTTGATCCCTCCACTGTCCAGGCTGTCTCAGGAGGAGGTGAATCAGAGCTAGTCTGTCACCTTTCCAATCTAA
GCCGAAGCCACAGGTGCCTGACAGGTTCCCTTCTAACAACTATTTGACCAAGAGAGGCAATCAGGGGGTTGTATACTGCACTGGATTCGC
CAGAGAAGGGAAAATTTAATTAGTGAAAAGGAAAGAACACTAGGAAACATTTGAGAACCTGCCTCTATCCCAGAATGTGCTGGAGATTTG
ACACTCAAATCAGTGTTTAGTCTTCTGCTTGGCACCATAGCTTAACCTGCAGTTTCTTCAAAATGCCCAATGCCTTGTTTCCTATTACCT
TAGATTGCAAACCAGTCTAGGGAAGTCTATGAGAAAGTAGCATTTAATTAAAGTTTAAAAAAAAAAAGGTTGGGCGTTGTGGCTCATGCC
TGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACTAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCTGTCT
GTACTAAAAATACAAAAATTAGCTGAGCATGGTGGCGTGTGCCTGTAATCTCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAAC
CCAGGAGGCGGAGGCTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTGGGAGACAGAGCAAGACTCAGTCTCAAAAAAAAAAAAA
AAAGCATTTTTCTGTTTTAATGTTTGGAGACTTTTTTTTTTGTTCTCTCCCTTTCCTGAACCCTATTCTGATCCTGAACCAAATTTATAG
CAATATAATTAGTGTTAATCTAAGGCATTACTCATCAAAAAAATTGCTGCAGTCTTTACAGTTGAATAAATAAAAACAACTGCATAAATA

>52421_52421_15_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000360430_SPATS2_chr12_49883248_ENST00000553127_length(amino acids)=493AA_BP=
MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE
SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK
KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ
MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL
TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER

--------------------------------------------------------------
>52421_52421_16_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000393410_SPATS2_chr12_49883248_ENST00000321898_length(transcript)=2901nt_BP=204nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTAGACCA
AAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATACTATGAAAGAGGTATGTAGACAACCAATTCAAATG
ATTGTGCTAACTTATTTCCCCTAGATAAATGCGGTACGTGCAATAGTTCCTAATAAGAGCAACAATGAAATTATCCTGGTTTTGCAGCAC
TTTGATAACTGTGTGGACAAAACAGTACAAGCATTCATGGAAGGTAGTGCCAGTGAAGTACTCAAAGAATGGACAGTAACAGGCAAGAAA
AAGAACAAAAAGAAGAAAAACAAACCGAAACCTGCCGCAGAACCAAGTAACGGCATCCCAGATTCCAGTAAATCAGTTTCCATTCAAGAG
GAACAGTCTGCGCCTTCCTCAGAGAAAGGTGGTATGAATGGCTACCATGTCAATGGTGCCATCAATGACACTGAGTCTGTGGACTCACTC
AGTGAAGGTTTGGAGACACTTTCAATAGATGCCAGAGAATTGGAGGATCCCGAGTCTGCCATGCTAGATACGCTGGATAGAACAGGATCC
ATGCTGCAGAATGGTGTCTCTGATTTTGAGACCAAGTCTTTGACTATGCACTCTATTCACAATTCTCAACAACCCAGGAATGCTGCCAAA
TCTCTCTCAAGACCTACCACAGAAACTCAGTTTTCAAATATGGGGATGGAAGATGTTCCCCTCGCCACCAGTAAAAAGCTAAGTTCCAAT
ATTGAAAAATCTGTAAAAGACCTCCAGCGCTGCACAGTGTCTCTTGCACGGTATCGAGTTGTAGTTAAAGAAGAGATGGATGCCTCCATT
AAGAAAATGAAACAAGCCTTTGCTGAATTGGAGAGCTGTTTAATGGATCGAGAAGTGGCGTTGCTTGCTGAAATGGACAAAGTGAAAGCT
GAAGCAATGGAAATTTTGCTCAGCCGACAAAAGAAGGCTGAACTTCTAAAGAAGATGACTCATGTGGCTGTTCAAATGTCAGAGCAGCAA
TTGGTTGAGCTCAGAGCTGATATCAAGCACTTTGTTAGTGAACGTAAATATGATGAGGATCTGGGACGAGTAGCCCGGTTCACCTGTGAT
GTAGAGACCCTAAAGAAGAGCATTGATTCATTTGGACAAGTGTCTCATCCAAAGAACAGCTATTCGACCAGATCCCGATGTAGCTCAGTT
ACATCTGTGTCCTTGAGTAGCCCAAGTGATGCCTCTGCTGCTTCCTCTTCCACCTGTGCCTCTCCTCCCAGCCTTACAAGTGCTAACAAG
AAAAACTTTGCACCGGGAGAGACTCCTGCAGCCATAGCAAACTCCAGTGGCCAGCCCTACCAGCCACTTCGGGAGGTATTGCCAGGGAAC
AGACGAGGAGGACAGGGCTATAGGCCACAAGGCCAAAAGTCCAATGACCCCATGAACCAAGGGCGGCATGACAGTATGGGTCGTTACAGA
AACAGCTCGTGGTATTCATCTGGTTCCAGGTATCAGAGTGCTCCATCTCAGGCACCAGGAAACACCATTGAAAGAGGCCAGACTCACTCT
GCAGGGACCAATGGAACTGGAGTCAGCATGGAGCCCAGCCCTCCCACGCCTTCATTCAAAAAGGGGCTCCCCCAGCGCAAACCCAGGACC
TCTCAGACTGAAGCCGTGAACTCTTGAGAGAAAATCCAGTTGGCCTCTCTCCTCTATCCACACAATTCAACTTGATAACTGGACTTTAGG
AAACTTACAGTTAGATGTAATAACAAAAAGAAGTTTATGCGTATCACTTTTTGTGCCATTCTAAGTATTTTTGGTTTCTTGTCTCCTTAT
TTCCTCTTTACCATTTTTGGAGGGGAAGCTATTTTTTTTCCTTGATCTTTCCCAGTGATATGGATTGAATCTGGTTGGTCATTTCCACCA
GGAATCAGAGGCAGCTGTTACCAGGTTTCGGCCTTCCAGTTGATCCCTCCACTGTCCAGGCTGTCTCAGGAGGAGGTGAATCAGAGCTAG
TCTGTCACCTTTCCAATCTAAGCCGAAGCCACAGGTGCCTGACAGGTTCCCTTCTAACAACTATTTGACCAAGAGAGGCAATCAGGGGGT
TGTATACTGCACTGGATTCGCCAGAGAAGGGAAAATTTAATTAGTGAAAAGGAAAGAACACTAGGAAACATTTGAGAACCTGCCTCTATC
CCAGAATGTGCTGGAGATTTGACACTCAAATCAGTGTTTAGTCTTCTGCTTGGCACCATAGCTTAACCTGCAGTTTCTTCAAAATGCCCA
ATGCCTTGTTTCCTATTACCTTAGATTGCAAACCAGTCTAGGGAAGTCTATGAGAAAGTAGCATTTAATTAAAGTTTAAAAAAAAAAAGG
TTGGGCGTTGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACTAGGTCAGGAGTTCAAGACCAGCCTGGC
CAACATGGTGAAACCCTGTCTGTACTAAAAATACAAAAATTAGCTGAGCATGGTGGCGTGTGCCTGTAATCTCAGCTACTCAGGAGGCTG
AGGCAGGAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTGGGAGACAGAGCAAGAC
TCAGTCTCAAAAAAAAAAAAAAAAGCATTTTTCTGTTTTAATGTTTGGAGACTTTTTTTTTTGTTCTCTCCCTTTCCTGAACCCTATTCT
GATCCTGAACCAAATTTATAGCAATATAATTAGTGTTAATCTAAGGCATTACTCATCAAAAAAATTGCTGCAGTCTTTACAGTTGAATAA

>52421_52421_16_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000393410_SPATS2_chr12_49883248_ENST00000321898_length(amino acids)=493AA_BP=
MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE
SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK
KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ
MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL
TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER

--------------------------------------------------------------
>52421_52421_17_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000393410_SPATS2_chr12_49883248_ENST00000552918_length(transcript)=2708nt_BP=204nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTAGACCA
AAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATACTATGAAAGAGGTATGTAGACAACCAATTCAAATG
ATTGTGCTAACTTATTTCCCCTAGATAAATGCGGTACGTGCAATAGTTCCTAATAAGAGCAACAATGAAATTATCCTGGTTTTGCAGCAC
TTTGATAACTGTGTGGACAAAACAGTACAAGCATTCATGGAAGGTAGTGCCAGTGAAGTACTCAAAGAATGGACAGTAACAGGCAAGAAA
AAGAACAAAAAGAAGAAAAACAAACCGAAACCTGCCGCAGAACCAAGTAACGGCATCCCAGATTCCAGTAAATCAGTTTCCATTCAAGAG
GAACAGTCTGCGCCTTCCTCAGAGAAAGGTGGTATGAATGGCTACCATGTCAATGGTGCCATCAATGACACTGAGTCTGTGGACTCACTC
AGTGAAGGTTTGGAGACACTTTCAATAGATGCCAGAGAATTGGAGGATCCCGAGTCTGCCATGCTAGATACGCTGGATAGAACAGGATCC
ATGCTGCAGAATGGTGTCTCTGATTTTGAGACCAAGTCTTTGACTATGCACTCTATTCACAATTCTCAACAACCCAGGAATGCTGCCAAA
TCTCTCTCAAGACCTACCACAGAAACTCAGTTTTCAAATATGGGGATGGAAGATGTTCCCCTCGCCACCAGTAAAAAGCTAAGTTCCAAT
ATTGAAAAATCTGTAAAAGACCTCCAGCGCTGCACAGTGTCTCTTGCACGGTATCGAGTTGTAGTTAAAGAAGAGATGGATGCCTCCATT
AAGAAAATGAAACAAGCCTTTGCTGAATTGGAGAGCTGTTTAATGGATCGAGAAGTGGCGTTGCTTGCTGAAATGGACAAAGTGAAAGCT
GAAGCAATGGAAATTTTGCTCAGCCGACAAAAGAAGGCTGAACTTCTAAAGAAGATGACTCATGTGGCTGTTCAAATGTCAGAGCAGCAA
TTGGTTGAGCTCAGAGCTGATATCAAGCACTTTGTTAGTGAACGTAAATATGATGAGGATCTGGGACGAGTAGCCCGGTTCACCTGTGAT
GTAGAGACCCTAAAGAAGAGCATTGATTCATTTGGACAAGTGTCTCATCCAAAGAACAGCTATTCGACCAGATCCCGATGTAGCTCAGTT
ACATCTGTGTCCTTGAGTAGCCCAAGTGATGCCTCTGCTGCTTCCTCTTCCACCTGTGCCTCTCCTCCCAGCCTTACAAGTGCTAACAAG
AAAAACTTTGCACCGGGAGAGACTCCTGCAGCCATAGCAAACTCCAGTGGCCAGCCCTACCAGCCACTTCGGGAGGTATTGCCAGGGAAC
AGACGAGGAGGACAGGGCTATAGGCCACAAGGCCAAAAGTCCAATGACCCCATGAACCAAGGGCGGCATGACAGTATGGGTCGTTACAGA
AACAGCTCGTGGTATTCATCTGGTTCCAGGTATCAGAGTGCTCCATCTCAGGCACCAGGAAACACCATTGAAAGAGGCCAGACTCACTCT
GCAGGGACCAATGGAACTGGAGTCAGCATGGAGCCCAGCCCTCCCACGCCTTCATTCAAAAAGGGGCTCCCCCAGCGCAAACCCAGGACC
TCTCAGACTGAAGCCGTGAACTCTTGAGAGAAAATCCAGTTGGCCTCTCTCCTCTATCCACACAATTCAACTTGATAACTGGACTTTAGG
AAACTTACAGTTAGATGTAATAACAAAAAGAAGTTTATGCGTATCACTTTTTGTGCCATTCTAAGTATTTTTGGTTTCTTGTCTCCTTAT
TTCCTCTTTACCATTTTTGGAGGGGAAGCTATTTTTTTTCCTTGATCTTTCCCAGTGATATGGATTGAATCTGGTTGGTCATTTCCACCA
GGAATCAGAGGCAGCTGTTACCAGGTTTCGGCCTTCCAGTTGATCCCTCCACTGTCCAGGCTGTCTCAGGAGGAGGTGAATCAGAGCTAG
TCTGTCACCTTTCCAATCTAAGCCGAAGCCACAGGTGCCTGACAGGTTCCCTTCTAACAACTATTTGACCAAGAGAGGCAATCAGGGGGT
TGTATACTGCACTGGATTCGCCAGAGAAGGGAAAATTTAATTAGTGAAAAGGAAAGAACACTAGGAAACATTTGAGAACCTGCCTCTATC
CCAGAATGTGCTGGAGATTTGACACTCAAATCAGTGTTTAGTCTTCTGCTTGGCACCATAGCTTAACCTGCAGTTTCTTCAAAATGCCCA
ATGCCTTGTTTCCTATTACCTTAGATTGCAAACCAGTCTAGGGAAGTCTATGAGAAAGTAGCATTTAATTAAAGTTTAAAAAAAAAAAGG
TTGGGCGTTGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACTAGGTCAGGAGTTCAAGACCAGCCTGGC
CAACATGGTGAAACCCTGTCTGTACTAAAAATACAAAAATTAGCTGAGCATGGTGGCGTGTGCCTGTAATCTCAGCTACTCAGGAGGCTG
AGGCAGGAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTGGGAGACAGAGCAAGAC

>52421_52421_17_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000393410_SPATS2_chr12_49883248_ENST00000552918_length(amino acids)=493AA_BP=
MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE
SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK
KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ
MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL
TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER

--------------------------------------------------------------
>52421_52421_18_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000393410_SPATS2_chr12_49883248_ENST00000553127_length(transcript)=2904nt_BP=204nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTAGACCA
AAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATACTATGAAAGAGGTATGTAGACAACCAATTCAAATG
ATTGTGCTAACTTATTTCCCCTAGATAAATGCGGTACGTGCAATAGTTCCTAATAAGAGCAACAATGAAATTATCCTGGTTTTGCAGCAC
TTTGATAACTGTGTGGACAAAACAGTACAAGCATTCATGGAAGGTAGTGCCAGTGAAGTACTCAAAGAATGGACAGTAACAGGCAAGAAA
AAGAACAAAAAGAAGAAAAACAAACCGAAACCTGCCGCAGAACCAAGTAACGGCATCCCAGATTCCAGTAAATCAGTTTCCATTCAAGAG
GAACAGTCTGCGCCTTCCTCAGAGAAAGGTGGTATGAATGGCTACCATGTCAATGGTGCCATCAATGACACTGAGTCTGTGGACTCACTC
AGTGAAGGTTTGGAGACACTTTCAATAGATGCCAGAGAATTGGAGGATCCCGAGTCTGCCATGCTAGATACGCTGGATAGAACAGGATCC
ATGCTGCAGAATGGTGTCTCTGATTTTGAGACCAAGTCTTTGACTATGCACTCTATTCACAATTCTCAACAACCCAGGAATGCTGCCAAA
TCTCTCTCAAGACCTACCACAGAAACTCAGTTTTCAAATATGGGGATGGAAGATGTTCCCCTCGCCACCAGTAAAAAGCTAAGTTCCAAT
ATTGAAAAATCTGTAAAAGACCTCCAGCGCTGCACAGTGTCTCTTGCACGGTATCGAGTTGTAGTTAAAGAAGAGATGGATGCCTCCATT
AAGAAAATGAAACAAGCCTTTGCTGAATTGGAGAGCTGTTTAATGGATCGAGAAGTGGCGTTGCTTGCTGAAATGGACAAAGTGAAAGCT
GAAGCAATGGAAATTTTGCTCAGCCGACAAAAGAAGGCTGAACTTCTAAAGAAGATGACTCATGTGGCTGTTCAAATGTCAGAGCAGCAA
TTGGTTGAGCTCAGAGCTGATATCAAGCACTTTGTTAGTGAACGTAAATATGATGAGGATCTGGGACGAGTAGCCCGGTTCACCTGTGAT
GTAGAGACCCTAAAGAAGAGCATTGATTCATTTGGACAAGTGTCTCATCCAAAGAACAGCTATTCGACCAGATCCCGATGTAGCTCAGTT
ACATCTGTGTCCTTGAGTAGCCCAAGTGATGCCTCTGCTGCTTCCTCTTCCACCTGTGCCTCTCCTCCCAGCCTTACAAGTGCTAACAAG
AAAAACTTTGCACCGGGAGAGACTCCTGCAGCCATAGCAAACTCCAGTGGCCAGCCCTACCAGCCACTTCGGGAGGTATTGCCAGGGAAC
AGACGAGGAGGACAGGGCTATAGGCCACAAGGCCAAAAGTCCAATGACCCCATGAACCAAGGGCGGCATGACAGTATGGGTCGTTACAGA
AACAGCTCGTGGTATTCATCTGGTTCCAGGTATCAGAGTGCTCCATCTCAGGCACCAGGAAACACCATTGAAAGAGGCCAGACTCACTCT
GCAGGGACCAATGGAACTGGAGTCAGCATGGAGCCCAGCCCTCCCACGCCTTCATTCAAAAAGGGGCTCCCCCAGCGCAAACCCAGGACC
TCTCAGACTGAAGCCGTGAACTCTTGAGAGAAAATCCAGTTGGCCTCTCTCCTCTATCCACACAATTCAACTTGATAACTGGACTTTAGG
AAACTTACAGTTAGATGTAATAACAAAAAGAAGTTTATGCGTATCACTTTTTGTGCCATTCTAAGTATTTTTGGTTTCTTGTCTCCTTAT
TTCCTCTTTACCATTTTTGGAGGGGAAGCTATTTTTTTTCCTTGATCTTTCCCAGTGATATGGATTGAATCTGGTTGGTCATTTCCACCA
GGAATCAGAGGCAGCTGTTACCAGGTTTCGGCCTTCCAGTTGATCCCTCCACTGTCCAGGCTGTCTCAGGAGGAGGTGAATCAGAGCTAG
TCTGTCACCTTTCCAATCTAAGCCGAAGCCACAGGTGCCTGACAGGTTCCCTTCTAACAACTATTTGACCAAGAGAGGCAATCAGGGGGT
TGTATACTGCACTGGATTCGCCAGAGAAGGGAAAATTTAATTAGTGAAAAGGAAAGAACACTAGGAAACATTTGAGAACCTGCCTCTATC
CCAGAATGTGCTGGAGATTTGACACTCAAATCAGTGTTTAGTCTTCTGCTTGGCACCATAGCTTAACCTGCAGTTTCTTCAAAATGCCCA
ATGCCTTGTTTCCTATTACCTTAGATTGCAAACCAGTCTAGGGAAGTCTATGAGAAAGTAGCATTTAATTAAAGTTTAAAAAAAAAAAGG
TTGGGCGTTGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACTAGGTCAGGAGTTCAAGACCAGCCTGGC
CAACATGGTGAAACCCTGTCTGTACTAAAAATACAAAAATTAGCTGAGCATGGTGGCGTGTGCCTGTAATCTCAGCTACTCAGGAGGCTG
AGGCAGGAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTGGGAGACAGAGCAAGAC
TCAGTCTCAAAAAAAAAAAAAAAAGCATTTTTCTGTTTTAATGTTTGGAGACTTTTTTTTTTGTTCTCTCCCTTTCCTGAACCCTATTCT
GATCCTGAACCAAATTTATAGCAATATAATTAGTGTTAATCTAAGGCATTACTCATCAAAAAAATTGCTGCAGTCTTTACAGTTGAATAA

>52421_52421_18_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000393410_SPATS2_chr12_49883248_ENST00000553127_length(amino acids)=493AA_BP=
MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE
SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK
KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ
MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL
TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER

--------------------------------------------------------------
>52421_52421_19_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000393412_SPATS2_chr12_49883248_ENST00000321898_length(transcript)=3340nt_BP=643nt
CTGTGTGGCCCTGTGTGTCGGAAAGATGGAGCAAGAAGCCGAGCCCGAGGGGCGGCCGCGACCCCTCTGACCGAGATCCTGCTGCTTTCG
CAGCCAGGAGCACCGTCCCTCCCCGGATTAGTGCGTACGAGCGCCCAGTGCCCTGGCCCGGAGAGTGGAATGATCCCCGAGGCCCAGGGC
GTCGTGCTTCCGCGCGCCCCGTGAAGGAAACTGGGGAGTCTTGAGGGACCCCCGACTCCAAGCGCGAAAACCCCGGATGGTGAGGAGCAG
GCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTATG
TAGACAACCAATTCAAATGATTGTGCTAACTTATTTCCCCTAGTTGACCTGTCTATAAGAGAATTATATATTTCTAACTATATAACCCTA
GGAATTTAGACAACCTGAAATTTATTCACATATATCAAAGTGAGAAAATGCCTCAATTCACATAGATTTCTTCTCTTTAGTATAATTGAC
CTACTTTGGTAGTGGAATAGTGAATACTTACTATAATTTGACTTGAATATGTAGCTCATCCTTTACACCAACTCCTAATTTTAAATAATT
TCTACTCTGTCTTATAAATGCGGTACGTGCAATAGTTCCTAATAAGAGCAACAATGAAATTATCCTGGTTTTGCAGCACTTTGATAACTG
TGTGGACAAAACAGTACAAGCATTCATGGAAGGTAGTGCCAGTGAAGTACTCAAAGAATGGACAGTAACAGGCAAGAAAAAGAACAAAAA
GAAGAAAAACAAACCGAAACCTGCCGCAGAACCAAGTAACGGCATCCCAGATTCCAGTAAATCAGTTTCCATTCAAGAGGAACAGTCTGC
GCCTTCCTCAGAGAAAGGTGGTATGAATGGCTACCATGTCAATGGTGCCATCAATGACACTGAGTCTGTGGACTCACTCAGTGAAGGTTT
GGAGACACTTTCAATAGATGCCAGAGAATTGGAGGATCCCGAGTCTGCCATGCTAGATACGCTGGATAGAACAGGATCCATGCTGCAGAA
TGGTGTCTCTGATTTTGAGACCAAGTCTTTGACTATGCACTCTATTCACAATTCTCAACAACCCAGGAATGCTGCCAAATCTCTCTCAAG
ACCTACCACAGAAACTCAGTTTTCAAATATGGGGATGGAAGATGTTCCCCTCGCCACCAGTAAAAAGCTAAGTTCCAATATTGAAAAATC
TGTAAAAGACCTCCAGCGCTGCACAGTGTCTCTTGCACGGTATCGAGTTGTAGTTAAAGAAGAGATGGATGCCTCCATTAAGAAAATGAA
ACAAGCCTTTGCTGAATTGGAGAGCTGTTTAATGGATCGAGAAGTGGCGTTGCTTGCTGAAATGGACAAAGTGAAAGCTGAAGCAATGGA
AATTTTGCTCAGCCGACAAAAGAAGGCTGAACTTCTAAAGAAGATGACTCATGTGGCTGTTCAAATGTCAGAGCAGCAATTGGTTGAGCT
CAGAGCTGATATCAAGCACTTTGTTAGTGAACGTAAATATGATGAGGATCTGGGACGAGTAGCCCGGTTCACCTGTGATGTAGAGACCCT
AAAGAAGAGCATTGATTCATTTGGACAAGTGTCTCATCCAAAGAACAGCTATTCGACCAGATCCCGATGTAGCTCAGTTACATCTGTGTC
CTTGAGTAGCCCAAGTGATGCCTCTGCTGCTTCCTCTTCCACCTGTGCCTCTCCTCCCAGCCTTACAAGTGCTAACAAGAAAAACTTTGC
ACCGGGAGAGACTCCTGCAGCCATAGCAAACTCCAGTGGCCAGCCCTACCAGCCACTTCGGGAGGTATTGCCAGGGAACAGACGAGGAGG
ACAGGGCTATAGGCCACAAGGCCAAAAGTCCAATGACCCCATGAACCAAGGGCGGCATGACAGTATGGGTCGTTACAGAAACAGCTCGTG
GTATTCATCTGGTTCCAGGTATCAGAGTGCTCCATCTCAGGCACCAGGAAACACCATTGAAAGAGGCCAGACTCACTCTGCAGGGACCAA
TGGAACTGGAGTCAGCATGGAGCCCAGCCCTCCCACGCCTTCATTCAAAAAGGGGCTCCCCCAGCGCAAACCCAGGACCTCTCAGACTGA
AGCCGTGAACTCTTGAGAGAAAATCCAGTTGGCCTCTCTCCTCTATCCACACAATTCAACTTGATAACTGGACTTTAGGAAACTTACAGT
TAGATGTAATAACAAAAAGAAGTTTATGCGTATCACTTTTTGTGCCATTCTAAGTATTTTTGGTTTCTTGTCTCCTTATTTCCTCTTTAC
CATTTTTGGAGGGGAAGCTATTTTTTTTCCTTGATCTTTCCCAGTGATATGGATTGAATCTGGTTGGTCATTTCCACCAGGAATCAGAGG
CAGCTGTTACCAGGTTTCGGCCTTCCAGTTGATCCCTCCACTGTCCAGGCTGTCTCAGGAGGAGGTGAATCAGAGCTAGTCTGTCACCTT
TCCAATCTAAGCCGAAGCCACAGGTGCCTGACAGGTTCCCTTCTAACAACTATTTGACCAAGAGAGGCAATCAGGGGGTTGTATACTGCA
CTGGATTCGCCAGAGAAGGGAAAATTTAATTAGTGAAAAGGAAAGAACACTAGGAAACATTTGAGAACCTGCCTCTATCCCAGAATGTGC
TGGAGATTTGACACTCAAATCAGTGTTTAGTCTTCTGCTTGGCACCATAGCTTAACCTGCAGTTTCTTCAAAATGCCCAATGCCTTGTTT
CCTATTACCTTAGATTGCAAACCAGTCTAGGGAAGTCTATGAGAAAGTAGCATTTAATTAAAGTTTAAAAAAAAAAAGGTTGGGCGTTGT
GGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACTAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGA
AACCCTGTCTGTACTAAAAATACAAAAATTAGCTGAGCATGGTGGCGTGTGCCTGTAATCTCAGCTACTCAGGAGGCTGAGGCAGGAGAA
TCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTGGGAGACAGAGCAAGACTCAGTCTCAAA
AAAAAAAAAAAAAGCATTTTTCTGTTTTAATGTTTGGAGACTTTTTTTTTTGTTCTCTCCCTTTCCTGAACCCTATTCTGATCCTGAACC
AAATTTATAGCAATATAATTAGTGTTAATCTAAGGCATTACTCATCAAAAAAATTGCTGCAGTCTTTACAGTTGAATAAATAAAAACAAC

>52421_52421_19_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000393412_SPATS2_chr12_49883248_ENST00000321898_length(amino acids)=493AA_BP=
MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE
SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK
KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ
MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL
TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER

--------------------------------------------------------------
>52421_52421_20_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000393412_SPATS2_chr12_49883248_ENST00000552918_length(transcript)=3147nt_BP=643nt
CTGTGTGGCCCTGTGTGTCGGAAAGATGGAGCAAGAAGCCGAGCCCGAGGGGCGGCCGCGACCCCTCTGACCGAGATCCTGCTGCTTTCG
CAGCCAGGAGCACCGTCCCTCCCCGGATTAGTGCGTACGAGCGCCCAGTGCCCTGGCCCGGAGAGTGGAATGATCCCCGAGGCCCAGGGC
GTCGTGCTTCCGCGCGCCCCGTGAAGGAAACTGGGGAGTCTTGAGGGACCCCCGACTCCAAGCGCGAAAACCCCGGATGGTGAGGAGCAG
GCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTATG
TAGACAACCAATTCAAATGATTGTGCTAACTTATTTCCCCTAGTTGACCTGTCTATAAGAGAATTATATATTTCTAACTATATAACCCTA
GGAATTTAGACAACCTGAAATTTATTCACATATATCAAAGTGAGAAAATGCCTCAATTCACATAGATTTCTTCTCTTTAGTATAATTGAC
CTACTTTGGTAGTGGAATAGTGAATACTTACTATAATTTGACTTGAATATGTAGCTCATCCTTTACACCAACTCCTAATTTTAAATAATT
TCTACTCTGTCTTATAAATGCGGTACGTGCAATAGTTCCTAATAAGAGCAACAATGAAATTATCCTGGTTTTGCAGCACTTTGATAACTG
TGTGGACAAAACAGTACAAGCATTCATGGAAGGTAGTGCCAGTGAAGTACTCAAAGAATGGACAGTAACAGGCAAGAAAAAGAACAAAAA
GAAGAAAAACAAACCGAAACCTGCCGCAGAACCAAGTAACGGCATCCCAGATTCCAGTAAATCAGTTTCCATTCAAGAGGAACAGTCTGC
GCCTTCCTCAGAGAAAGGTGGTATGAATGGCTACCATGTCAATGGTGCCATCAATGACACTGAGTCTGTGGACTCACTCAGTGAAGGTTT
GGAGACACTTTCAATAGATGCCAGAGAATTGGAGGATCCCGAGTCTGCCATGCTAGATACGCTGGATAGAACAGGATCCATGCTGCAGAA
TGGTGTCTCTGATTTTGAGACCAAGTCTTTGACTATGCACTCTATTCACAATTCTCAACAACCCAGGAATGCTGCCAAATCTCTCTCAAG
ACCTACCACAGAAACTCAGTTTTCAAATATGGGGATGGAAGATGTTCCCCTCGCCACCAGTAAAAAGCTAAGTTCCAATATTGAAAAATC
TGTAAAAGACCTCCAGCGCTGCACAGTGTCTCTTGCACGGTATCGAGTTGTAGTTAAAGAAGAGATGGATGCCTCCATTAAGAAAATGAA
ACAAGCCTTTGCTGAATTGGAGAGCTGTTTAATGGATCGAGAAGTGGCGTTGCTTGCTGAAATGGACAAAGTGAAAGCTGAAGCAATGGA
AATTTTGCTCAGCCGACAAAAGAAGGCTGAACTTCTAAAGAAGATGACTCATGTGGCTGTTCAAATGTCAGAGCAGCAATTGGTTGAGCT
CAGAGCTGATATCAAGCACTTTGTTAGTGAACGTAAATATGATGAGGATCTGGGACGAGTAGCCCGGTTCACCTGTGATGTAGAGACCCT
AAAGAAGAGCATTGATTCATTTGGACAAGTGTCTCATCCAAAGAACAGCTATTCGACCAGATCCCGATGTAGCTCAGTTACATCTGTGTC
CTTGAGTAGCCCAAGTGATGCCTCTGCTGCTTCCTCTTCCACCTGTGCCTCTCCTCCCAGCCTTACAAGTGCTAACAAGAAAAACTTTGC
ACCGGGAGAGACTCCTGCAGCCATAGCAAACTCCAGTGGCCAGCCCTACCAGCCACTTCGGGAGGTATTGCCAGGGAACAGACGAGGAGG
ACAGGGCTATAGGCCACAAGGCCAAAAGTCCAATGACCCCATGAACCAAGGGCGGCATGACAGTATGGGTCGTTACAGAAACAGCTCGTG
GTATTCATCTGGTTCCAGGTATCAGAGTGCTCCATCTCAGGCACCAGGAAACACCATTGAAAGAGGCCAGACTCACTCTGCAGGGACCAA
TGGAACTGGAGTCAGCATGGAGCCCAGCCCTCCCACGCCTTCATTCAAAAAGGGGCTCCCCCAGCGCAAACCCAGGACCTCTCAGACTGA
AGCCGTGAACTCTTGAGAGAAAATCCAGTTGGCCTCTCTCCTCTATCCACACAATTCAACTTGATAACTGGACTTTAGGAAACTTACAGT
TAGATGTAATAACAAAAAGAAGTTTATGCGTATCACTTTTTGTGCCATTCTAAGTATTTTTGGTTTCTTGTCTCCTTATTTCCTCTTTAC
CATTTTTGGAGGGGAAGCTATTTTTTTTCCTTGATCTTTCCCAGTGATATGGATTGAATCTGGTTGGTCATTTCCACCAGGAATCAGAGG
CAGCTGTTACCAGGTTTCGGCCTTCCAGTTGATCCCTCCACTGTCCAGGCTGTCTCAGGAGGAGGTGAATCAGAGCTAGTCTGTCACCTT
TCCAATCTAAGCCGAAGCCACAGGTGCCTGACAGGTTCCCTTCTAACAACTATTTGACCAAGAGAGGCAATCAGGGGGTTGTATACTGCA
CTGGATTCGCCAGAGAAGGGAAAATTTAATTAGTGAAAAGGAAAGAACACTAGGAAACATTTGAGAACCTGCCTCTATCCCAGAATGTGC
TGGAGATTTGACACTCAAATCAGTGTTTAGTCTTCTGCTTGGCACCATAGCTTAACCTGCAGTTTCTTCAAAATGCCCAATGCCTTGTTT
CCTATTACCTTAGATTGCAAACCAGTCTAGGGAAGTCTATGAGAAAGTAGCATTTAATTAAAGTTTAAAAAAAAAAAGGTTGGGCGTTGT
GGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACTAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGA
AACCCTGTCTGTACTAAAAATACAAAAATTAGCTGAGCATGGTGGCGTGTGCCTGTAATCTCAGCTACTCAGGAGGCTGAGGCAGGAGAA

>52421_52421_20_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000393412_SPATS2_chr12_49883248_ENST00000552918_length(amino acids)=493AA_BP=
MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE
SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK
KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ
MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL
TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER

--------------------------------------------------------------
>52421_52421_21_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000393412_SPATS2_chr12_49883248_ENST00000553127_length(transcript)=3343nt_BP=643nt
CTGTGTGGCCCTGTGTGTCGGAAAGATGGAGCAAGAAGCCGAGCCCGAGGGGCGGCCGCGACCCCTCTGACCGAGATCCTGCTGCTTTCG
CAGCCAGGAGCACCGTCCCTCCCCGGATTAGTGCGTACGAGCGCCCAGTGCCCTGGCCCGGAGAGTGGAATGATCCCCGAGGCCCAGGGC
GTCGTGCTTCCGCGCGCCCCGTGAAGGAAACTGGGGAGTCTTGAGGGACCCCCGACTCCAAGCGCGAAAACCCCGGATGGTGAGGAGCAG
GCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTATG
TAGACAACCAATTCAAATGATTGTGCTAACTTATTTCCCCTAGTTGACCTGTCTATAAGAGAATTATATATTTCTAACTATATAACCCTA
GGAATTTAGACAACCTGAAATTTATTCACATATATCAAAGTGAGAAAATGCCTCAATTCACATAGATTTCTTCTCTTTAGTATAATTGAC
CTACTTTGGTAGTGGAATAGTGAATACTTACTATAATTTGACTTGAATATGTAGCTCATCCTTTACACCAACTCCTAATTTTAAATAATT
TCTACTCTGTCTTATAAATGCGGTACGTGCAATAGTTCCTAATAAGAGCAACAATGAAATTATCCTGGTTTTGCAGCACTTTGATAACTG
TGTGGACAAAACAGTACAAGCATTCATGGAAGGTAGTGCCAGTGAAGTACTCAAAGAATGGACAGTAACAGGCAAGAAAAAGAACAAAAA
GAAGAAAAACAAACCGAAACCTGCCGCAGAACCAAGTAACGGCATCCCAGATTCCAGTAAATCAGTTTCCATTCAAGAGGAACAGTCTGC
GCCTTCCTCAGAGAAAGGTGGTATGAATGGCTACCATGTCAATGGTGCCATCAATGACACTGAGTCTGTGGACTCACTCAGTGAAGGTTT
GGAGACACTTTCAATAGATGCCAGAGAATTGGAGGATCCCGAGTCTGCCATGCTAGATACGCTGGATAGAACAGGATCCATGCTGCAGAA
TGGTGTCTCTGATTTTGAGACCAAGTCTTTGACTATGCACTCTATTCACAATTCTCAACAACCCAGGAATGCTGCCAAATCTCTCTCAAG
ACCTACCACAGAAACTCAGTTTTCAAATATGGGGATGGAAGATGTTCCCCTCGCCACCAGTAAAAAGCTAAGTTCCAATATTGAAAAATC
TGTAAAAGACCTCCAGCGCTGCACAGTGTCTCTTGCACGGTATCGAGTTGTAGTTAAAGAAGAGATGGATGCCTCCATTAAGAAAATGAA
ACAAGCCTTTGCTGAATTGGAGAGCTGTTTAATGGATCGAGAAGTGGCGTTGCTTGCTGAAATGGACAAAGTGAAAGCTGAAGCAATGGA
AATTTTGCTCAGCCGACAAAAGAAGGCTGAACTTCTAAAGAAGATGACTCATGTGGCTGTTCAAATGTCAGAGCAGCAATTGGTTGAGCT
CAGAGCTGATATCAAGCACTTTGTTAGTGAACGTAAATATGATGAGGATCTGGGACGAGTAGCCCGGTTCACCTGTGATGTAGAGACCCT
AAAGAAGAGCATTGATTCATTTGGACAAGTGTCTCATCCAAAGAACAGCTATTCGACCAGATCCCGATGTAGCTCAGTTACATCTGTGTC
CTTGAGTAGCCCAAGTGATGCCTCTGCTGCTTCCTCTTCCACCTGTGCCTCTCCTCCCAGCCTTACAAGTGCTAACAAGAAAAACTTTGC
ACCGGGAGAGACTCCTGCAGCCATAGCAAACTCCAGTGGCCAGCCCTACCAGCCACTTCGGGAGGTATTGCCAGGGAACAGACGAGGAGG
ACAGGGCTATAGGCCACAAGGCCAAAAGTCCAATGACCCCATGAACCAAGGGCGGCATGACAGTATGGGTCGTTACAGAAACAGCTCGTG
GTATTCATCTGGTTCCAGGTATCAGAGTGCTCCATCTCAGGCACCAGGAAACACCATTGAAAGAGGCCAGACTCACTCTGCAGGGACCAA
TGGAACTGGAGTCAGCATGGAGCCCAGCCCTCCCACGCCTTCATTCAAAAAGGGGCTCCCCCAGCGCAAACCCAGGACCTCTCAGACTGA
AGCCGTGAACTCTTGAGAGAAAATCCAGTTGGCCTCTCTCCTCTATCCACACAATTCAACTTGATAACTGGACTTTAGGAAACTTACAGT
TAGATGTAATAACAAAAAGAAGTTTATGCGTATCACTTTTTGTGCCATTCTAAGTATTTTTGGTTTCTTGTCTCCTTATTTCCTCTTTAC
CATTTTTGGAGGGGAAGCTATTTTTTTTCCTTGATCTTTCCCAGTGATATGGATTGAATCTGGTTGGTCATTTCCACCAGGAATCAGAGG
CAGCTGTTACCAGGTTTCGGCCTTCCAGTTGATCCCTCCACTGTCCAGGCTGTCTCAGGAGGAGGTGAATCAGAGCTAGTCTGTCACCTT
TCCAATCTAAGCCGAAGCCACAGGTGCCTGACAGGTTCCCTTCTAACAACTATTTGACCAAGAGAGGCAATCAGGGGGTTGTATACTGCA
CTGGATTCGCCAGAGAAGGGAAAATTTAATTAGTGAAAAGGAAAGAACACTAGGAAACATTTGAGAACCTGCCTCTATCCCAGAATGTGC
TGGAGATTTGACACTCAAATCAGTGTTTAGTCTTCTGCTTGGCACCATAGCTTAACCTGCAGTTTCTTCAAAATGCCCAATGCCTTGTTT
CCTATTACCTTAGATTGCAAACCAGTCTAGGGAAGTCTATGAGAAAGTAGCATTTAATTAAAGTTTAAAAAAAAAAAGGTTGGGCGTTGT
GGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACTAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGA
AACCCTGTCTGTACTAAAAATACAAAAATTAGCTGAGCATGGTGGCGTGTGCCTGTAATCTCAGCTACTCAGGAGGCTGAGGCAGGAGAA
TCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTGGGAGACAGAGCAAGACTCAGTCTCAAA
AAAAAAAAAAAAAGCATTTTTCTGTTTTAATGTTTGGAGACTTTTTTTTTTGTTCTCTCCCTTTCCTGAACCCTATTCTGATCCTGAACC
AAATTTATAGCAATATAATTAGTGTTAATCTAAGGCATTACTCATCAAAAAAATTGCTGCAGTCTTTACAGTTGAATAAATAAAAACAAC

>52421_52421_21_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000393412_SPATS2_chr12_49883248_ENST00000553127_length(amino acids)=493AA_BP=
MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE
SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK
KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ
MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL
TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER

--------------------------------------------------------------
>52421_52421_22_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000393413_SPATS2_chr12_49883248_ENST00000321898_length(transcript)=2826nt_BP=129nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTATGTAGA
CAACCAATTCAAATGATTGTGCTAACTTATTTCCCCTAGATAAATGCGGTACGTGCAATAGTTCCTAATAAGAGCAACAATGAAATTATC
CTGGTTTTGCAGCACTTTGATAACTGTGTGGACAAAACAGTACAAGCATTCATGGAAGGTAGTGCCAGTGAAGTACTCAAAGAATGGACA
GTAACAGGCAAGAAAAAGAACAAAAAGAAGAAAAACAAACCGAAACCTGCCGCAGAACCAAGTAACGGCATCCCAGATTCCAGTAAATCA
GTTTCCATTCAAGAGGAACAGTCTGCGCCTTCCTCAGAGAAAGGTGGTATGAATGGCTACCATGTCAATGGTGCCATCAATGACACTGAG
TCTGTGGACTCACTCAGTGAAGGTTTGGAGACACTTTCAATAGATGCCAGAGAATTGGAGGATCCCGAGTCTGCCATGCTAGATACGCTG
GATAGAACAGGATCCATGCTGCAGAATGGTGTCTCTGATTTTGAGACCAAGTCTTTGACTATGCACTCTATTCACAATTCTCAACAACCC
AGGAATGCTGCCAAATCTCTCTCAAGACCTACCACAGAAACTCAGTTTTCAAATATGGGGATGGAAGATGTTCCCCTCGCCACCAGTAAA
AAGCTAAGTTCCAATATTGAAAAATCTGTAAAAGACCTCCAGCGCTGCACAGTGTCTCTTGCACGGTATCGAGTTGTAGTTAAAGAAGAG
ATGGATGCCTCCATTAAGAAAATGAAACAAGCCTTTGCTGAATTGGAGAGCTGTTTAATGGATCGAGAAGTGGCGTTGCTTGCTGAAATG
GACAAAGTGAAAGCTGAAGCAATGGAAATTTTGCTCAGCCGACAAAAGAAGGCTGAACTTCTAAAGAAGATGACTCATGTGGCTGTTCAA
ATGTCAGAGCAGCAATTGGTTGAGCTCAGAGCTGATATCAAGCACTTTGTTAGTGAACGTAAATATGATGAGGATCTGGGACGAGTAGCC
CGGTTCACCTGTGATGTAGAGACCCTAAAGAAGAGCATTGATTCATTTGGACAAGTGTCTCATCCAAAGAACAGCTATTCGACCAGATCC
CGATGTAGCTCAGTTACATCTGTGTCCTTGAGTAGCCCAAGTGATGCCTCTGCTGCTTCCTCTTCCACCTGTGCCTCTCCTCCCAGCCTT
ACAAGTGCTAACAAGAAAAACTTTGCACCGGGAGAGACTCCTGCAGCCATAGCAAACTCCAGTGGCCAGCCCTACCAGCCACTTCGGGAG
GTATTGCCAGGGAACAGACGAGGAGGACAGGGCTATAGGCCACAAGGCCAAAAGTCCAATGACCCCATGAACCAAGGGCGGCATGACAGT
ATGGGTCGTTACAGAAACAGCTCGTGGTATTCATCTGGTTCCAGGTATCAGAGTGCTCCATCTCAGGCACCAGGAAACACCATTGAAAGA
GGCCAGACTCACTCTGCAGGGACCAATGGAACTGGAGTCAGCATGGAGCCCAGCCCTCCCACGCCTTCATTCAAAAAGGGGCTCCCCCAG
CGCAAACCCAGGACCTCTCAGACTGAAGCCGTGAACTCTTGAGAGAAAATCCAGTTGGCCTCTCTCCTCTATCCACACAATTCAACTTGA
TAACTGGACTTTAGGAAACTTACAGTTAGATGTAATAACAAAAAGAAGTTTATGCGTATCACTTTTTGTGCCATTCTAAGTATTTTTGGT
TTCTTGTCTCCTTATTTCCTCTTTACCATTTTTGGAGGGGAAGCTATTTTTTTTCCTTGATCTTTCCCAGTGATATGGATTGAATCTGGT
TGGTCATTTCCACCAGGAATCAGAGGCAGCTGTTACCAGGTTTCGGCCTTCCAGTTGATCCCTCCACTGTCCAGGCTGTCTCAGGAGGAG
GTGAATCAGAGCTAGTCTGTCACCTTTCCAATCTAAGCCGAAGCCACAGGTGCCTGACAGGTTCCCTTCTAACAACTATTTGACCAAGAG
AGGCAATCAGGGGGTTGTATACTGCACTGGATTCGCCAGAGAAGGGAAAATTTAATTAGTGAAAAGGAAAGAACACTAGGAAACATTTGA
GAACCTGCCTCTATCCCAGAATGTGCTGGAGATTTGACACTCAAATCAGTGTTTAGTCTTCTGCTTGGCACCATAGCTTAACCTGCAGTT
TCTTCAAAATGCCCAATGCCTTGTTTCCTATTACCTTAGATTGCAAACCAGTCTAGGGAAGTCTATGAGAAAGTAGCATTTAATTAAAGT
TTAAAAAAAAAAAGGTTGGGCGTTGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACTAGGTCAGGAGTT
CAAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTGTACTAAAAATACAAAAATTAGCTGAGCATGGTGGCGTGTGCCTGTAATCTCAG
CTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTGG
GAGACAGAGCAAGACTCAGTCTCAAAAAAAAAAAAAAAAGCATTTTTCTGTTTTAATGTTTGGAGACTTTTTTTTTTGTTCTCTCCCTTT
CCTGAACCCTATTCTGATCCTGAACCAAATTTATAGCAATATAATTAGTGTTAATCTAAGGCATTACTCATCAAAAAAATTGCTGCAGTC

>52421_52421_22_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000393413_SPATS2_chr12_49883248_ENST00000321898_length(amino acids)=493AA_BP=
MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE
SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK
KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ
MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL
TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER

--------------------------------------------------------------
>52421_52421_23_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000393413_SPATS2_chr12_49883248_ENST00000552918_length(transcript)=2633nt_BP=129nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTATGTAGA
CAACCAATTCAAATGATTGTGCTAACTTATTTCCCCTAGATAAATGCGGTACGTGCAATAGTTCCTAATAAGAGCAACAATGAAATTATC
CTGGTTTTGCAGCACTTTGATAACTGTGTGGACAAAACAGTACAAGCATTCATGGAAGGTAGTGCCAGTGAAGTACTCAAAGAATGGACA
GTAACAGGCAAGAAAAAGAACAAAAAGAAGAAAAACAAACCGAAACCTGCCGCAGAACCAAGTAACGGCATCCCAGATTCCAGTAAATCA
GTTTCCATTCAAGAGGAACAGTCTGCGCCTTCCTCAGAGAAAGGTGGTATGAATGGCTACCATGTCAATGGTGCCATCAATGACACTGAG
TCTGTGGACTCACTCAGTGAAGGTTTGGAGACACTTTCAATAGATGCCAGAGAATTGGAGGATCCCGAGTCTGCCATGCTAGATACGCTG
GATAGAACAGGATCCATGCTGCAGAATGGTGTCTCTGATTTTGAGACCAAGTCTTTGACTATGCACTCTATTCACAATTCTCAACAACCC
AGGAATGCTGCCAAATCTCTCTCAAGACCTACCACAGAAACTCAGTTTTCAAATATGGGGATGGAAGATGTTCCCCTCGCCACCAGTAAA
AAGCTAAGTTCCAATATTGAAAAATCTGTAAAAGACCTCCAGCGCTGCACAGTGTCTCTTGCACGGTATCGAGTTGTAGTTAAAGAAGAG
ATGGATGCCTCCATTAAGAAAATGAAACAAGCCTTTGCTGAATTGGAGAGCTGTTTAATGGATCGAGAAGTGGCGTTGCTTGCTGAAATG
GACAAAGTGAAAGCTGAAGCAATGGAAATTTTGCTCAGCCGACAAAAGAAGGCTGAACTTCTAAAGAAGATGACTCATGTGGCTGTTCAA
ATGTCAGAGCAGCAATTGGTTGAGCTCAGAGCTGATATCAAGCACTTTGTTAGTGAACGTAAATATGATGAGGATCTGGGACGAGTAGCC
CGGTTCACCTGTGATGTAGAGACCCTAAAGAAGAGCATTGATTCATTTGGACAAGTGTCTCATCCAAAGAACAGCTATTCGACCAGATCC
CGATGTAGCTCAGTTACATCTGTGTCCTTGAGTAGCCCAAGTGATGCCTCTGCTGCTTCCTCTTCCACCTGTGCCTCTCCTCCCAGCCTT
ACAAGTGCTAACAAGAAAAACTTTGCACCGGGAGAGACTCCTGCAGCCATAGCAAACTCCAGTGGCCAGCCCTACCAGCCACTTCGGGAG
GTATTGCCAGGGAACAGACGAGGAGGACAGGGCTATAGGCCACAAGGCCAAAAGTCCAATGACCCCATGAACCAAGGGCGGCATGACAGT
ATGGGTCGTTACAGAAACAGCTCGTGGTATTCATCTGGTTCCAGGTATCAGAGTGCTCCATCTCAGGCACCAGGAAACACCATTGAAAGA
GGCCAGACTCACTCTGCAGGGACCAATGGAACTGGAGTCAGCATGGAGCCCAGCCCTCCCACGCCTTCATTCAAAAAGGGGCTCCCCCAG
CGCAAACCCAGGACCTCTCAGACTGAAGCCGTGAACTCTTGAGAGAAAATCCAGTTGGCCTCTCTCCTCTATCCACACAATTCAACTTGA
TAACTGGACTTTAGGAAACTTACAGTTAGATGTAATAACAAAAAGAAGTTTATGCGTATCACTTTTTGTGCCATTCTAAGTATTTTTGGT
TTCTTGTCTCCTTATTTCCTCTTTACCATTTTTGGAGGGGAAGCTATTTTTTTTCCTTGATCTTTCCCAGTGATATGGATTGAATCTGGT
TGGTCATTTCCACCAGGAATCAGAGGCAGCTGTTACCAGGTTTCGGCCTTCCAGTTGATCCCTCCACTGTCCAGGCTGTCTCAGGAGGAG
GTGAATCAGAGCTAGTCTGTCACCTTTCCAATCTAAGCCGAAGCCACAGGTGCCTGACAGGTTCCCTTCTAACAACTATTTGACCAAGAG
AGGCAATCAGGGGGTTGTATACTGCACTGGATTCGCCAGAGAAGGGAAAATTTAATTAGTGAAAAGGAAAGAACACTAGGAAACATTTGA
GAACCTGCCTCTATCCCAGAATGTGCTGGAGATTTGACACTCAAATCAGTGTTTAGTCTTCTGCTTGGCACCATAGCTTAACCTGCAGTT
TCTTCAAAATGCCCAATGCCTTGTTTCCTATTACCTTAGATTGCAAACCAGTCTAGGGAAGTCTATGAGAAAGTAGCATTTAATTAAAGT
TTAAAAAAAAAAAGGTTGGGCGTTGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACTAGGTCAGGAGTT
CAAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTGTACTAAAAATACAAAAATTAGCTGAGCATGGTGGCGTGTGCCTGTAATCTCAG
CTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTGG

>52421_52421_23_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000393413_SPATS2_chr12_49883248_ENST00000552918_length(amino acids)=493AA_BP=
MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE
SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK
KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ
MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL
TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER

--------------------------------------------------------------
>52421_52421_24_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000393413_SPATS2_chr12_49883248_ENST00000553127_length(transcript)=2829nt_BP=129nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTATGTAGA
CAACCAATTCAAATGATTGTGCTAACTTATTTCCCCTAGATAAATGCGGTACGTGCAATAGTTCCTAATAAGAGCAACAATGAAATTATC
CTGGTTTTGCAGCACTTTGATAACTGTGTGGACAAAACAGTACAAGCATTCATGGAAGGTAGTGCCAGTGAAGTACTCAAAGAATGGACA
GTAACAGGCAAGAAAAAGAACAAAAAGAAGAAAAACAAACCGAAACCTGCCGCAGAACCAAGTAACGGCATCCCAGATTCCAGTAAATCA
GTTTCCATTCAAGAGGAACAGTCTGCGCCTTCCTCAGAGAAAGGTGGTATGAATGGCTACCATGTCAATGGTGCCATCAATGACACTGAG
TCTGTGGACTCACTCAGTGAAGGTTTGGAGACACTTTCAATAGATGCCAGAGAATTGGAGGATCCCGAGTCTGCCATGCTAGATACGCTG
GATAGAACAGGATCCATGCTGCAGAATGGTGTCTCTGATTTTGAGACCAAGTCTTTGACTATGCACTCTATTCACAATTCTCAACAACCC
AGGAATGCTGCCAAATCTCTCTCAAGACCTACCACAGAAACTCAGTTTTCAAATATGGGGATGGAAGATGTTCCCCTCGCCACCAGTAAA
AAGCTAAGTTCCAATATTGAAAAATCTGTAAAAGACCTCCAGCGCTGCACAGTGTCTCTTGCACGGTATCGAGTTGTAGTTAAAGAAGAG
ATGGATGCCTCCATTAAGAAAATGAAACAAGCCTTTGCTGAATTGGAGAGCTGTTTAATGGATCGAGAAGTGGCGTTGCTTGCTGAAATG
GACAAAGTGAAAGCTGAAGCAATGGAAATTTTGCTCAGCCGACAAAAGAAGGCTGAACTTCTAAAGAAGATGACTCATGTGGCTGTTCAA
ATGTCAGAGCAGCAATTGGTTGAGCTCAGAGCTGATATCAAGCACTTTGTTAGTGAACGTAAATATGATGAGGATCTGGGACGAGTAGCC
CGGTTCACCTGTGATGTAGAGACCCTAAAGAAGAGCATTGATTCATTTGGACAAGTGTCTCATCCAAAGAACAGCTATTCGACCAGATCC
CGATGTAGCTCAGTTACATCTGTGTCCTTGAGTAGCCCAAGTGATGCCTCTGCTGCTTCCTCTTCCACCTGTGCCTCTCCTCCCAGCCTT
ACAAGTGCTAACAAGAAAAACTTTGCACCGGGAGAGACTCCTGCAGCCATAGCAAACTCCAGTGGCCAGCCCTACCAGCCACTTCGGGAG
GTATTGCCAGGGAACAGACGAGGAGGACAGGGCTATAGGCCACAAGGCCAAAAGTCCAATGACCCCATGAACCAAGGGCGGCATGACAGT
ATGGGTCGTTACAGAAACAGCTCGTGGTATTCATCTGGTTCCAGGTATCAGAGTGCTCCATCTCAGGCACCAGGAAACACCATTGAAAGA
GGCCAGACTCACTCTGCAGGGACCAATGGAACTGGAGTCAGCATGGAGCCCAGCCCTCCCACGCCTTCATTCAAAAAGGGGCTCCCCCAG
CGCAAACCCAGGACCTCTCAGACTGAAGCCGTGAACTCTTGAGAGAAAATCCAGTTGGCCTCTCTCCTCTATCCACACAATTCAACTTGA
TAACTGGACTTTAGGAAACTTACAGTTAGATGTAATAACAAAAAGAAGTTTATGCGTATCACTTTTTGTGCCATTCTAAGTATTTTTGGT
TTCTTGTCTCCTTATTTCCTCTTTACCATTTTTGGAGGGGAAGCTATTTTTTTTCCTTGATCTTTCCCAGTGATATGGATTGAATCTGGT
TGGTCATTTCCACCAGGAATCAGAGGCAGCTGTTACCAGGTTTCGGCCTTCCAGTTGATCCCTCCACTGTCCAGGCTGTCTCAGGAGGAG
GTGAATCAGAGCTAGTCTGTCACCTTTCCAATCTAAGCCGAAGCCACAGGTGCCTGACAGGTTCCCTTCTAACAACTATTTGACCAAGAG
AGGCAATCAGGGGGTTGTATACTGCACTGGATTCGCCAGAGAAGGGAAAATTTAATTAGTGAAAAGGAAAGAACACTAGGAAACATTTGA
GAACCTGCCTCTATCCCAGAATGTGCTGGAGATTTGACACTCAAATCAGTGTTTAGTCTTCTGCTTGGCACCATAGCTTAACCTGCAGTT
TCTTCAAAATGCCCAATGCCTTGTTTCCTATTACCTTAGATTGCAAACCAGTCTAGGGAAGTCTATGAGAAAGTAGCATTTAATTAAAGT
TTAAAAAAAAAAAGGTTGGGCGTTGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACTAGGTCAGGAGTT
CAAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTGTACTAAAAATACAAAAATTAGCTGAGCATGGTGGCGTGTGCCTGTAATCTCAG
CTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTGG
GAGACAGAGCAAGACTCAGTCTCAAAAAAAAAAAAAAAAGCATTTTTCTGTTTTAATGTTTGGAGACTTTTTTTTTTGTTCTCTCCCTTT
CCTGAACCCTATTCTGATCCTGAACCAAATTTATAGCAATATAATTAGTGTTAATCTAAGGCATTACTCATCAAAAAAATTGCTGCAGTC

>52421_52421_24_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000393413_SPATS2_chr12_49883248_ENST00000553127_length(amino acids)=493AA_BP=
MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE
SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK
KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ
MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL
TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER

--------------------------------------------------------------
>52421_52421_25_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000517852_SPATS2_chr12_49883248_ENST00000321898_length(transcript)=2901nt_BP=204nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTAGACCA
AAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATACTATGAAAGAGGTATGTAGACAACCAATTCAAATG
ATTGTGCTAACTTATTTCCCCTAGATAAATGCGGTACGTGCAATAGTTCCTAATAAGAGCAACAATGAAATTATCCTGGTTTTGCAGCAC
TTTGATAACTGTGTGGACAAAACAGTACAAGCATTCATGGAAGGTAGTGCCAGTGAAGTACTCAAAGAATGGACAGTAACAGGCAAGAAA
AAGAACAAAAAGAAGAAAAACAAACCGAAACCTGCCGCAGAACCAAGTAACGGCATCCCAGATTCCAGTAAATCAGTTTCCATTCAAGAG
GAACAGTCTGCGCCTTCCTCAGAGAAAGGTGGTATGAATGGCTACCATGTCAATGGTGCCATCAATGACACTGAGTCTGTGGACTCACTC
AGTGAAGGTTTGGAGACACTTTCAATAGATGCCAGAGAATTGGAGGATCCCGAGTCTGCCATGCTAGATACGCTGGATAGAACAGGATCC
ATGCTGCAGAATGGTGTCTCTGATTTTGAGACCAAGTCTTTGACTATGCACTCTATTCACAATTCTCAACAACCCAGGAATGCTGCCAAA
TCTCTCTCAAGACCTACCACAGAAACTCAGTTTTCAAATATGGGGATGGAAGATGTTCCCCTCGCCACCAGTAAAAAGCTAAGTTCCAAT
ATTGAAAAATCTGTAAAAGACCTCCAGCGCTGCACAGTGTCTCTTGCACGGTATCGAGTTGTAGTTAAAGAAGAGATGGATGCCTCCATT
AAGAAAATGAAACAAGCCTTTGCTGAATTGGAGAGCTGTTTAATGGATCGAGAAGTGGCGTTGCTTGCTGAAATGGACAAAGTGAAAGCT
GAAGCAATGGAAATTTTGCTCAGCCGACAAAAGAAGGCTGAACTTCTAAAGAAGATGACTCATGTGGCTGTTCAAATGTCAGAGCAGCAA
TTGGTTGAGCTCAGAGCTGATATCAAGCACTTTGTTAGTGAACGTAAATATGATGAGGATCTGGGACGAGTAGCCCGGTTCACCTGTGAT
GTAGAGACCCTAAAGAAGAGCATTGATTCATTTGGACAAGTGTCTCATCCAAAGAACAGCTATTCGACCAGATCCCGATGTAGCTCAGTT
ACATCTGTGTCCTTGAGTAGCCCAAGTGATGCCTCTGCTGCTTCCTCTTCCACCTGTGCCTCTCCTCCCAGCCTTACAAGTGCTAACAAG
AAAAACTTTGCACCGGGAGAGACTCCTGCAGCCATAGCAAACTCCAGTGGCCAGCCCTACCAGCCACTTCGGGAGGTATTGCCAGGGAAC
AGACGAGGAGGACAGGGCTATAGGCCACAAGGCCAAAAGTCCAATGACCCCATGAACCAAGGGCGGCATGACAGTATGGGTCGTTACAGA
AACAGCTCGTGGTATTCATCTGGTTCCAGGTATCAGAGTGCTCCATCTCAGGCACCAGGAAACACCATTGAAAGAGGCCAGACTCACTCT
GCAGGGACCAATGGAACTGGAGTCAGCATGGAGCCCAGCCCTCCCACGCCTTCATTCAAAAAGGGGCTCCCCCAGCGCAAACCCAGGACC
TCTCAGACTGAAGCCGTGAACTCTTGAGAGAAAATCCAGTTGGCCTCTCTCCTCTATCCACACAATTCAACTTGATAACTGGACTTTAGG
AAACTTACAGTTAGATGTAATAACAAAAAGAAGTTTATGCGTATCACTTTTTGTGCCATTCTAAGTATTTTTGGTTTCTTGTCTCCTTAT
TTCCTCTTTACCATTTTTGGAGGGGAAGCTATTTTTTTTCCTTGATCTTTCCCAGTGATATGGATTGAATCTGGTTGGTCATTTCCACCA
GGAATCAGAGGCAGCTGTTACCAGGTTTCGGCCTTCCAGTTGATCCCTCCACTGTCCAGGCTGTCTCAGGAGGAGGTGAATCAGAGCTAG
TCTGTCACCTTTCCAATCTAAGCCGAAGCCACAGGTGCCTGACAGGTTCCCTTCTAACAACTATTTGACCAAGAGAGGCAATCAGGGGGT
TGTATACTGCACTGGATTCGCCAGAGAAGGGAAAATTTAATTAGTGAAAAGGAAAGAACACTAGGAAACATTTGAGAACCTGCCTCTATC
CCAGAATGTGCTGGAGATTTGACACTCAAATCAGTGTTTAGTCTTCTGCTTGGCACCATAGCTTAACCTGCAGTTTCTTCAAAATGCCCA
ATGCCTTGTTTCCTATTACCTTAGATTGCAAACCAGTCTAGGGAAGTCTATGAGAAAGTAGCATTTAATTAAAGTTTAAAAAAAAAAAGG
TTGGGCGTTGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACTAGGTCAGGAGTTCAAGACCAGCCTGGC
CAACATGGTGAAACCCTGTCTGTACTAAAAATACAAAAATTAGCTGAGCATGGTGGCGTGTGCCTGTAATCTCAGCTACTCAGGAGGCTG
AGGCAGGAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTGGGAGACAGAGCAAGAC
TCAGTCTCAAAAAAAAAAAAAAAAGCATTTTTCTGTTTTAATGTTTGGAGACTTTTTTTTTTGTTCTCTCCCTTTCCTGAACCCTATTCT
GATCCTGAACCAAATTTATAGCAATATAATTAGTGTTAATCTAAGGCATTACTCATCAAAAAAATTGCTGCAGTCTTTACAGTTGAATAA

>52421_52421_25_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000517852_SPATS2_chr12_49883248_ENST00000321898_length(amino acids)=493AA_BP=
MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE
SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK
KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ
MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL
TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER

--------------------------------------------------------------
>52421_52421_26_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000517852_SPATS2_chr12_49883248_ENST00000552918_length(transcript)=2708nt_BP=204nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTAGACCA
AAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATACTATGAAAGAGGTATGTAGACAACCAATTCAAATG
ATTGTGCTAACTTATTTCCCCTAGATAAATGCGGTACGTGCAATAGTTCCTAATAAGAGCAACAATGAAATTATCCTGGTTTTGCAGCAC
TTTGATAACTGTGTGGACAAAACAGTACAAGCATTCATGGAAGGTAGTGCCAGTGAAGTACTCAAAGAATGGACAGTAACAGGCAAGAAA
AAGAACAAAAAGAAGAAAAACAAACCGAAACCTGCCGCAGAACCAAGTAACGGCATCCCAGATTCCAGTAAATCAGTTTCCATTCAAGAG
GAACAGTCTGCGCCTTCCTCAGAGAAAGGTGGTATGAATGGCTACCATGTCAATGGTGCCATCAATGACACTGAGTCTGTGGACTCACTC
AGTGAAGGTTTGGAGACACTTTCAATAGATGCCAGAGAATTGGAGGATCCCGAGTCTGCCATGCTAGATACGCTGGATAGAACAGGATCC
ATGCTGCAGAATGGTGTCTCTGATTTTGAGACCAAGTCTTTGACTATGCACTCTATTCACAATTCTCAACAACCCAGGAATGCTGCCAAA
TCTCTCTCAAGACCTACCACAGAAACTCAGTTTTCAAATATGGGGATGGAAGATGTTCCCCTCGCCACCAGTAAAAAGCTAAGTTCCAAT
ATTGAAAAATCTGTAAAAGACCTCCAGCGCTGCACAGTGTCTCTTGCACGGTATCGAGTTGTAGTTAAAGAAGAGATGGATGCCTCCATT
AAGAAAATGAAACAAGCCTTTGCTGAATTGGAGAGCTGTTTAATGGATCGAGAAGTGGCGTTGCTTGCTGAAATGGACAAAGTGAAAGCT
GAAGCAATGGAAATTTTGCTCAGCCGACAAAAGAAGGCTGAACTTCTAAAGAAGATGACTCATGTGGCTGTTCAAATGTCAGAGCAGCAA
TTGGTTGAGCTCAGAGCTGATATCAAGCACTTTGTTAGTGAACGTAAATATGATGAGGATCTGGGACGAGTAGCCCGGTTCACCTGTGAT
GTAGAGACCCTAAAGAAGAGCATTGATTCATTTGGACAAGTGTCTCATCCAAAGAACAGCTATTCGACCAGATCCCGATGTAGCTCAGTT
ACATCTGTGTCCTTGAGTAGCCCAAGTGATGCCTCTGCTGCTTCCTCTTCCACCTGTGCCTCTCCTCCCAGCCTTACAAGTGCTAACAAG
AAAAACTTTGCACCGGGAGAGACTCCTGCAGCCATAGCAAACTCCAGTGGCCAGCCCTACCAGCCACTTCGGGAGGTATTGCCAGGGAAC
AGACGAGGAGGACAGGGCTATAGGCCACAAGGCCAAAAGTCCAATGACCCCATGAACCAAGGGCGGCATGACAGTATGGGTCGTTACAGA
AACAGCTCGTGGTATTCATCTGGTTCCAGGTATCAGAGTGCTCCATCTCAGGCACCAGGAAACACCATTGAAAGAGGCCAGACTCACTCT
GCAGGGACCAATGGAACTGGAGTCAGCATGGAGCCCAGCCCTCCCACGCCTTCATTCAAAAAGGGGCTCCCCCAGCGCAAACCCAGGACC
TCTCAGACTGAAGCCGTGAACTCTTGAGAGAAAATCCAGTTGGCCTCTCTCCTCTATCCACACAATTCAACTTGATAACTGGACTTTAGG
AAACTTACAGTTAGATGTAATAACAAAAAGAAGTTTATGCGTATCACTTTTTGTGCCATTCTAAGTATTTTTGGTTTCTTGTCTCCTTAT
TTCCTCTTTACCATTTTTGGAGGGGAAGCTATTTTTTTTCCTTGATCTTTCCCAGTGATATGGATTGAATCTGGTTGGTCATTTCCACCA
GGAATCAGAGGCAGCTGTTACCAGGTTTCGGCCTTCCAGTTGATCCCTCCACTGTCCAGGCTGTCTCAGGAGGAGGTGAATCAGAGCTAG
TCTGTCACCTTTCCAATCTAAGCCGAAGCCACAGGTGCCTGACAGGTTCCCTTCTAACAACTATTTGACCAAGAGAGGCAATCAGGGGGT
TGTATACTGCACTGGATTCGCCAGAGAAGGGAAAATTTAATTAGTGAAAAGGAAAGAACACTAGGAAACATTTGAGAACCTGCCTCTATC
CCAGAATGTGCTGGAGATTTGACACTCAAATCAGTGTTTAGTCTTCTGCTTGGCACCATAGCTTAACCTGCAGTTTCTTCAAAATGCCCA
ATGCCTTGTTTCCTATTACCTTAGATTGCAAACCAGTCTAGGGAAGTCTATGAGAAAGTAGCATTTAATTAAAGTTTAAAAAAAAAAAGG
TTGGGCGTTGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACTAGGTCAGGAGTTCAAGACCAGCCTGGC
CAACATGGTGAAACCCTGTCTGTACTAAAAATACAAAAATTAGCTGAGCATGGTGGCGTGTGCCTGTAATCTCAGCTACTCAGGAGGCTG
AGGCAGGAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTGGGAGACAGAGCAAGAC

>52421_52421_26_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000517852_SPATS2_chr12_49883248_ENST00000552918_length(amino acids)=493AA_BP=
MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE
SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK
KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ
MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL
TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER

--------------------------------------------------------------
>52421_52421_27_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000517852_SPATS2_chr12_49883248_ENST00000553127_length(transcript)=2904nt_BP=204nt
ATGTGCAATACCAACATGTCTGTACCTACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTAGACCA
AAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATACTATGAAAGAGGTATGTAGACAACCAATTCAAATG
ATTGTGCTAACTTATTTCCCCTAGATAAATGCGGTACGTGCAATAGTTCCTAATAAGAGCAACAATGAAATTATCCTGGTTTTGCAGCAC
TTTGATAACTGTGTGGACAAAACAGTACAAGCATTCATGGAAGGTAGTGCCAGTGAAGTACTCAAAGAATGGACAGTAACAGGCAAGAAA
AAGAACAAAAAGAAGAAAAACAAACCGAAACCTGCCGCAGAACCAAGTAACGGCATCCCAGATTCCAGTAAATCAGTTTCCATTCAAGAG
GAACAGTCTGCGCCTTCCTCAGAGAAAGGTGGTATGAATGGCTACCATGTCAATGGTGCCATCAATGACACTGAGTCTGTGGACTCACTC
AGTGAAGGTTTGGAGACACTTTCAATAGATGCCAGAGAATTGGAGGATCCCGAGTCTGCCATGCTAGATACGCTGGATAGAACAGGATCC
ATGCTGCAGAATGGTGTCTCTGATTTTGAGACCAAGTCTTTGACTATGCACTCTATTCACAATTCTCAACAACCCAGGAATGCTGCCAAA
TCTCTCTCAAGACCTACCACAGAAACTCAGTTTTCAAATATGGGGATGGAAGATGTTCCCCTCGCCACCAGTAAAAAGCTAAGTTCCAAT
ATTGAAAAATCTGTAAAAGACCTCCAGCGCTGCACAGTGTCTCTTGCACGGTATCGAGTTGTAGTTAAAGAAGAGATGGATGCCTCCATT
AAGAAAATGAAACAAGCCTTTGCTGAATTGGAGAGCTGTTTAATGGATCGAGAAGTGGCGTTGCTTGCTGAAATGGACAAAGTGAAAGCT
GAAGCAATGGAAATTTTGCTCAGCCGACAAAAGAAGGCTGAACTTCTAAAGAAGATGACTCATGTGGCTGTTCAAATGTCAGAGCAGCAA
TTGGTTGAGCTCAGAGCTGATATCAAGCACTTTGTTAGTGAACGTAAATATGATGAGGATCTGGGACGAGTAGCCCGGTTCACCTGTGAT
GTAGAGACCCTAAAGAAGAGCATTGATTCATTTGGACAAGTGTCTCATCCAAAGAACAGCTATTCGACCAGATCCCGATGTAGCTCAGTT
ACATCTGTGTCCTTGAGTAGCCCAAGTGATGCCTCTGCTGCTTCCTCTTCCACCTGTGCCTCTCCTCCCAGCCTTACAAGTGCTAACAAG
AAAAACTTTGCACCGGGAGAGACTCCTGCAGCCATAGCAAACTCCAGTGGCCAGCCCTACCAGCCACTTCGGGAGGTATTGCCAGGGAAC
AGACGAGGAGGACAGGGCTATAGGCCACAAGGCCAAAAGTCCAATGACCCCATGAACCAAGGGCGGCATGACAGTATGGGTCGTTACAGA
AACAGCTCGTGGTATTCATCTGGTTCCAGGTATCAGAGTGCTCCATCTCAGGCACCAGGAAACACCATTGAAAGAGGCCAGACTCACTCT
GCAGGGACCAATGGAACTGGAGTCAGCATGGAGCCCAGCCCTCCCACGCCTTCATTCAAAAAGGGGCTCCCCCAGCGCAAACCCAGGACC
TCTCAGACTGAAGCCGTGAACTCTTGAGAGAAAATCCAGTTGGCCTCTCTCCTCTATCCACACAATTCAACTTGATAACTGGACTTTAGG
AAACTTACAGTTAGATGTAATAACAAAAAGAAGTTTATGCGTATCACTTTTTGTGCCATTCTAAGTATTTTTGGTTTCTTGTCTCCTTAT
TTCCTCTTTACCATTTTTGGAGGGGAAGCTATTTTTTTTCCTTGATCTTTCCCAGTGATATGGATTGAATCTGGTTGGTCATTTCCACCA
GGAATCAGAGGCAGCTGTTACCAGGTTTCGGCCTTCCAGTTGATCCCTCCACTGTCCAGGCTGTCTCAGGAGGAGGTGAATCAGAGCTAG
TCTGTCACCTTTCCAATCTAAGCCGAAGCCACAGGTGCCTGACAGGTTCCCTTCTAACAACTATTTGACCAAGAGAGGCAATCAGGGGGT
TGTATACTGCACTGGATTCGCCAGAGAAGGGAAAATTTAATTAGTGAAAAGGAAAGAACACTAGGAAACATTTGAGAACCTGCCTCTATC
CCAGAATGTGCTGGAGATTTGACACTCAAATCAGTGTTTAGTCTTCTGCTTGGCACCATAGCTTAACCTGCAGTTTCTTCAAAATGCCCA
ATGCCTTGTTTCCTATTACCTTAGATTGCAAACCAGTCTAGGGAAGTCTATGAGAAAGTAGCATTTAATTAAAGTTTAAAAAAAAAAAGG
TTGGGCGTTGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACTAGGTCAGGAGTTCAAGACCAGCCTGGC
CAACATGGTGAAACCCTGTCTGTACTAAAAATACAAAAATTAGCTGAGCATGGTGGCGTGTGCCTGTAATCTCAGCTACTCAGGAGGCTG
AGGCAGGAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTGGGAGACAGAGCAAGAC
TCAGTCTCAAAAAAAAAAAAAAAAGCATTTTTCTGTTTTAATGTTTGGAGACTTTTTTTTTTGTTCTCTCCCTTTCCTGAACCCTATTCT
GATCCTGAACCAAATTTATAGCAATATAATTAGTGTTAATCTAAGGCATTACTCATCAAAAAAATTGCTGCAGTCTTTACAGTTGAATAA

>52421_52421_27_MDM2-SPATS2_MDM2_chr12_69233581_ENST00000517852_SPATS2_chr12_49883248_ENST00000553127_length(amino acids)=493AA_BP=
MVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTE
SVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSK
KLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQ
MSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSL
TSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIER

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MDM2-SPATS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMDM2chr12:69233581chr12:49883248ENST00000258149+19170_3060437.0MTBP
HgeneMDM2chr12:69233581chr12:49883248ENST00000299252+15170_3060.0322.0MTBP
HgeneMDM2chr12:69233581chr12:49883248ENST00000348801+13170_3060.0266.0MTBP
HgeneMDM2chr12:69233581chr12:49883248ENST00000356290+16170_3060322.0MTBP
HgeneMDM2chr12:69233581chr12:49883248ENST00000360430+14170_3060.0297.0MTBP
HgeneMDM2chr12:69233581chr12:49883248ENST00000393412+13170_3060219.0MTBP
HgeneMDM2chr12:69233581chr12:49883248ENST00000393413+12170_3060.0219.0MTBP
HgeneMDM2chr12:69233581chr12:49883248ENST00000428863+14170_3060271.0MTBP
HgeneMDM2chr12:69233581chr12:49883248ENST00000462284+111170_3060498.0MTBP
HgeneMDM2chr12:69233581chr12:49883248ENST00000540827+15170_3060297.0MTBP
HgeneMDM2chr12:69233581chr12:49883248ENST00000258149+19150_2300437.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69233581chr12:49883248ENST00000299252+15150_2300.0322.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69233581chr12:49883248ENST00000348801+13150_2300.0266.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69233581chr12:49883248ENST00000356290+16150_2300322.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69233581chr12:49883248ENST00000360430+14150_2300.0297.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69233581chr12:49883248ENST00000393412+13150_2300219.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69233581chr12:49883248ENST00000393413+12150_2300.0219.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69233581chr12:49883248ENST00000428863+14150_2300271.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69233581chr12:49883248ENST00000462284+111150_2300498.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69233581chr12:49883248ENST00000540827+15150_2300297.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69233581chr12:49883248ENST00000258149+19223_2320437.0USP7
HgeneMDM2chr12:69233581chr12:49883248ENST00000299252+15223_2320.0322.0USP7
HgeneMDM2chr12:69233581chr12:49883248ENST00000348801+13223_2320.0266.0USP7
HgeneMDM2chr12:69233581chr12:49883248ENST00000356290+16223_2320322.0USP7
HgeneMDM2chr12:69233581chr12:49883248ENST00000360430+14223_2320.0297.0USP7
HgeneMDM2chr12:69233581chr12:49883248ENST00000393412+13223_2320219.0USP7
HgeneMDM2chr12:69233581chr12:49883248ENST00000393413+12223_2320.0219.0USP7
HgeneMDM2chr12:69233581chr12:49883248ENST00000428863+14223_2320271.0USP7
HgeneMDM2chr12:69233581chr12:49883248ENST00000462284+111223_2320498.0USP7
HgeneMDM2chr12:69233581chr12:49883248ENST00000540827+15223_2320297.0USP7


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MDM2-SPATS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MDM2-SPATS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource