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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MECOM-FRMD5 (FusionGDB2 ID:52496)

Fusion Gene Summary for MECOM-FRMD5

check button Fusion gene summary
Fusion gene informationFusion gene name: MECOM-FRMD5
Fusion gene ID: 52496
HgeneTgene
Gene symbol

MECOM

FRMD5

Gene ID

2122

84978

Gene nameMDS1 and EVI1 complex locusFERM domain containing 5
SynonymsAML1-EVI-1|EVI1|KMT8E|MDS1|MDS1-EVI1|PRDM3|RUSAT2-
Cytomap

3q26.2

15q15.3

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase MECOMAML1-EVI-1 fusion proteinMDS1 and EVI1 complex locus protein EVI1MDS1 and EVI1 complex locus protein MDS1PR domain 3ecotropic virus integration site 1 protein homologmyelodysplasia syndrome-associated protein FERM domain-containing protein 5
Modification date2020031320200313
UniProtAcc

Q03112

Q7Z6J6

Ensembl transtripts involved in fusion geneENST00000264674, ENST00000392736, 
ENST00000433243, ENST00000472280, 
ENST00000494292, ENST00000460814, 
ENST00000464456, ENST00000468789, 
ENST00000485957, 		ENST00000402883, 
ENST00000417257, ENST00000484674, 
Fusion gene scores* DoF score33 X 21 X 11=762315 X 17 X 5=1275
# samples 4318
** MAII scorelog2(43/7623*10)=-4.14795031118505
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1275*10)=-2.82442843541655
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MECOM [Title/Abstract] AND FRMD5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMECOM(168810746)-FRMD5(44180464), # samples:3
Anticipated loss of major functional domain due to fusion event.MECOM-FRMD5 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
MECOM-FRMD5 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
MECOM-FRMD5 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
MECOM-FRMD5 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMECOM

GO:0045892

negative regulation of transcription, DNA-templated

10856240|11568182

HgeneMECOM

GO:0045893

positive regulation of transcription, DNA-templated

11568182|19767769

HgeneMECOM

GO:0051726

regulation of cell cycle

11568182


check buttonFusion gene breakpoints across MECOM (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FRMD5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-91-7771-01AMECOMchr3

168810746

-FRMD5chr15

44180464

-


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Fusion Gene ORF analysis for MECOM-FRMD5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000264674ENST00000402883MECOMchr3

168810746

-FRMD5chr15

44180464

-
Frame-shiftENST00000264674ENST00000417257MECOMchr3

168810746

-FRMD5chr15

44180464

-
Frame-shiftENST00000264674ENST00000484674MECOMchr3

168810746

-FRMD5chr15

44180464

-
Frame-shiftENST00000392736ENST00000402883MECOMchr3

168810746

-FRMD5chr15

44180464

-
Frame-shiftENST00000392736ENST00000417257MECOMchr3

168810746

-FRMD5chr15

44180464

-
Frame-shiftENST00000392736ENST00000484674MECOMchr3

168810746

-FRMD5chr15

44180464

-
Frame-shiftENST00000433243ENST00000402883MECOMchr3

168810746

-FRMD5chr15

44180464

-
Frame-shiftENST00000433243ENST00000417257MECOMchr3

168810746

-FRMD5chr15

44180464

-
Frame-shiftENST00000433243ENST00000484674MECOMchr3

168810746

-FRMD5chr15

44180464

-
Frame-shiftENST00000472280ENST00000402883MECOMchr3

168810746

-FRMD5chr15

44180464

-
Frame-shiftENST00000472280ENST00000417257MECOMchr3

168810746

-FRMD5chr15

44180464

-
Frame-shiftENST00000472280ENST00000484674MECOMchr3

168810746

-FRMD5chr15

44180464

-
Frame-shiftENST00000494292ENST00000402883MECOMchr3

168810746

-FRMD5chr15

44180464

-
Frame-shiftENST00000494292ENST00000417257MECOMchr3

168810746

-FRMD5chr15

44180464

-
Frame-shiftENST00000494292ENST00000484674MECOMchr3

168810746

-FRMD5chr15

44180464

-
In-frameENST00000460814ENST00000402883MECOMchr3

168810746

-FRMD5chr15

44180464

-
In-frameENST00000460814ENST00000417257MECOMchr3

168810746

-FRMD5chr15

44180464

-
In-frameENST00000460814ENST00000484674MECOMchr3

168810746

-FRMD5chr15

44180464

-
In-frameENST00000464456ENST00000402883MECOMchr3

168810746

-FRMD5chr15

44180464

-
In-frameENST00000464456ENST00000417257MECOMchr3

168810746

-FRMD5chr15

44180464

-
In-frameENST00000464456ENST00000484674MECOMchr3

168810746

-FRMD5chr15

44180464

-
In-frameENST00000468789ENST00000402883MECOMchr3

168810746

-FRMD5chr15

44180464

-
In-frameENST00000468789ENST00000417257MECOMchr3

168810746

-FRMD5chr15

44180464

-
In-frameENST00000468789ENST00000484674MECOMchr3

168810746

-FRMD5chr15

44180464

-
intron-3CDSENST00000485957ENST00000402883MECOMchr3

168810746

-FRMD5chr15

44180464

-
intron-3CDSENST00000485957ENST00000417257MECOMchr3

168810746

-FRMD5chr15

44180464

-
intron-3CDSENST00000485957ENST00000484674MECOMchr3

168810746

-FRMD5chr15

44180464

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000464456MECOMchr3168810746-ENST00000417257FRMD5chr1544180464-7816377411924047951
ENST00000464456MECOMchr3168810746-ENST00000402883FRMD5chr1544180464-6917377411924047951
ENST00000464456MECOMchr3168810746-ENST00000484674FRMD5chr1544180464-5126377411924047951
ENST00000468789MECOMchr3168810746-ENST00000417257FRMD5chr1544180464-703029882532611078
ENST00000468789MECOMchr3168810746-ENST00000402883FRMD5chr1544180464-613129882532611078
ENST00000468789MECOMchr3168810746-ENST00000484674FRMD5chr1544180464-434029882532611078
ENST00000460814MECOMchr3168810746-ENST00000417257FRMD5chr1544180464-67282686442959971
ENST00000460814MECOMchr3168810746-ENST00000402883FRMD5chr1544180464-58292686442959971
ENST00000460814MECOMchr3168810746-ENST00000484674FRMD5chr1544180464-40382686442959971

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000464456ENST00000417257MECOMchr3168810746-FRMD5chr1544180464-0.001032730.9989673
ENST00000464456ENST00000402883MECOMchr3168810746-FRMD5chr1544180464-0.0008906280.9991093
ENST00000464456ENST00000484674MECOMchr3168810746-FRMD5chr1544180464-0.0017291570.99827087
ENST00000468789ENST00000417257MECOMchr3168810746-FRMD5chr1544180464-0.000527390.9994727
ENST00000468789ENST00000402883MECOMchr3168810746-FRMD5chr1544180464-0.0004399620.99956006
ENST00000468789ENST00000484674MECOMchr3168810746-FRMD5chr1544180464-0.0012410390.9987589
ENST00000460814ENST00000417257MECOMchr3168810746-FRMD5chr1544180464-0.0003571330.99964285
ENST00000460814ENST00000402883MECOMchr3168810746-FRMD5chr1544180464-0.0002982570.9997017
ENST00000460814ENST00000484674MECOMchr3168810746-FRMD5chr1544180464-0.0008220420.999178

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Fusion Genomic Features for MECOM-FRMD5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MECOM-FRMD5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:168810746/chr15:44180464)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MECOM

Q03112

FRMD5

Q7Z6J6

FUNCTION: [Isoform 1]: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. {ECO:0000269|PubMed:10856240, ECO:0000269|PubMed:11568182, ECO:0000269|PubMed:15897867, ECO:0000269|PubMed:16462766, ECO:0000269|PubMed:19767769, ECO:0000269|PubMed:9665135}.; FUNCTION: [Isoform 7]: Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation. {ECO:0000250|UniProtKB:P14404}.FUNCTION: May be involved in regulation of cell migration (PubMed:22846708, PubMed:25448675). May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail interactions such as with FERMT2 and TLN1. May regulate ROCK1 kinase activity possibly involved in regulation of actin stress fiber formation (PubMed:25448675).

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMECOMchr3:168810746chr15:44180464ENST00000264674-141778_1909311117.0DomainSET
HgeneMECOMchr3:168810746chr15:44180464ENST00000392736-131678_1908661052.0DomainSET
HgeneMECOMchr3:168810746chr15:44180464ENST00000433243-141778_1908671053.0DomainSET
HgeneMECOMchr3:168810746chr15:44180464ENST00000464456-121578_1908571043.0DomainSET
HgeneMECOMchr3:168810746chr15:44180464ENST00000468789-131678_1908661052.0DomainSET
HgeneMECOMchr3:168810746chr15:44180464ENST00000472280-131678_1908671053.0DomainSET
HgeneMECOMchr3:168810746chr15:44180464ENST00000264674-1417609_6229311117.0MotifNuclear localization signal
HgeneMECOMchr3:168810746chr15:44180464ENST00000264674-1417741_7459311117.0MotifCTBP-binding motif 1
HgeneMECOMchr3:168810746chr15:44180464ENST00000264674-1417772_7769311117.0MotifCTBP-binding motif 2
HgeneMECOMchr3:168810746chr15:44180464ENST00000392736-1316609_6228661052.0MotifNuclear localization signal
HgeneMECOMchr3:168810746chr15:44180464ENST00000392736-1316741_7458661052.0MotifCTBP-binding motif 1
HgeneMECOMchr3:168810746chr15:44180464ENST00000392736-1316772_7768661052.0MotifCTBP-binding motif 2
HgeneMECOMchr3:168810746chr15:44180464ENST00000433243-1417609_6228671053.0MotifNuclear localization signal
HgeneMECOMchr3:168810746chr15:44180464ENST00000433243-1417741_7458671053.0MotifCTBP-binding motif 1
HgeneMECOMchr3:168810746chr15:44180464ENST00000433243-1417772_7768671053.0MotifCTBP-binding motif 2
HgeneMECOMchr3:168810746chr15:44180464ENST00000464456-1215609_6228571043.0MotifNuclear localization signal
HgeneMECOMchr3:168810746chr15:44180464ENST00000464456-1215741_7458571043.0MotifCTBP-binding motif 1
HgeneMECOMchr3:168810746chr15:44180464ENST00000464456-1215772_7768571043.0MotifCTBP-binding motif 2
HgeneMECOMchr3:168810746chr15:44180464ENST00000468789-1316609_6228661052.0MotifNuclear localization signal
HgeneMECOMchr3:168810746chr15:44180464ENST00000468789-1316741_7458661052.0MotifCTBP-binding motif 1
HgeneMECOMchr3:168810746chr15:44180464ENST00000468789-1316772_7768661052.0MotifCTBP-binding motif 2
HgeneMECOMchr3:168810746chr15:44180464ENST00000472280-1316609_6228671053.0MotifNuclear localization signal
HgeneMECOMchr3:168810746chr15:44180464ENST00000472280-1316741_7458671053.0MotifCTBP-binding motif 1
HgeneMECOMchr3:168810746chr15:44180464ENST00000472280-1316772_7768671053.0MotifCTBP-binding motif 2
HgeneMECOMchr3:168810746chr15:44180464ENST00000264674-1417209_2369311117.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:168810746chr15:44180464ENST00000264674-1417263_2859311117.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:168810746chr15:44180464ENST00000264674-1417291_3139311117.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:168810746chr15:44180464ENST00000264674-1417319_3429311117.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:168810746chr15:44180464ENST00000264674-1417348_3709311117.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:168810746chr15:44180464ENST00000264674-1417376_3989311117.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:168810746chr15:44180464ENST00000264674-1417405_4279311117.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:168810746chr15:44180464ENST00000264674-1417912_9349311117.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:168810746chr15:44180464ENST00000392736-1316209_2368661052.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:168810746chr15:44180464ENST00000392736-1316263_2858661052.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:168810746chr15:44180464ENST00000392736-1316291_3138661052.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:168810746chr15:44180464ENST00000392736-1316319_3428661052.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:168810746chr15:44180464ENST00000392736-1316348_3708661052.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:168810746chr15:44180464ENST00000392736-1316376_3988661052.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:168810746chr15:44180464ENST00000392736-1316405_4278661052.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:168810746chr15:44180464ENST00000433243-1417209_2368671053.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:168810746chr15:44180464ENST00000433243-1417263_2858671053.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:168810746chr15:44180464ENST00000433243-1417291_3138671053.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:168810746chr15:44180464ENST00000433243-1417319_3428671053.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:168810746chr15:44180464ENST00000433243-1417348_3708671053.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:168810746chr15:44180464ENST00000433243-1417376_3988671053.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:168810746chr15:44180464ENST00000433243-1417405_4278671053.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:168810746chr15:44180464ENST00000464456-1215209_2368571043.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:168810746chr15:44180464ENST00000464456-1215263_2858571043.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:168810746chr15:44180464ENST00000464456-1215291_3138571043.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:168810746chr15:44180464ENST00000464456-1215319_3428571043.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:168810746chr15:44180464ENST00000464456-1215348_3708571043.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:168810746chr15:44180464ENST00000464456-1215376_3988571043.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:168810746chr15:44180464ENST00000464456-1215405_4278571043.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:168810746chr15:44180464ENST00000468789-1316209_2368661052.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:168810746chr15:44180464ENST00000468789-1316263_2858661052.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:168810746chr15:44180464ENST00000468789-1316291_3138661052.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:168810746chr15:44180464ENST00000468789-1316319_3428661052.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:168810746chr15:44180464ENST00000468789-1316348_3708661052.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:168810746chr15:44180464ENST00000468789-1316376_3988661052.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:168810746chr15:44180464ENST00000468789-1316405_4278661052.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:168810746chr15:44180464ENST00000472280-1316209_2368671053.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:168810746chr15:44180464ENST00000472280-1316263_2858671053.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:168810746chr15:44180464ENST00000472280-1316291_3138671053.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:168810746chr15:44180464ENST00000472280-1316319_3428671053.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:168810746chr15:44180464ENST00000472280-1316348_3708671053.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:168810746chr15:44180464ENST00000472280-1316376_3988671053.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:168810746chr15:44180464ENST00000472280-1316405_4278671053.0Zinc fingerC2H2-type 7%3B atypical
TgeneFRMD5chr3:168810746chr15:44180464ENST00000417257814504_524264571.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMECOMchr3:168810746chr15:44180464ENST00000264674-14171065_11169311117.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:168810746chr15:44180464ENST00000392736-13161065_11168661052.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:168810746chr15:44180464ENST00000433243-14171065_11168671053.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:168810746chr15:44180464ENST00000464456-12151065_11168571043.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:168810746chr15:44180464ENST00000468789-13161065_11168661052.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:168810746chr15:44180464ENST00000472280-13161065_11168671053.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:168810746chr15:44180464ENST00000264674-1417940_9639311117.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:168810746chr15:44180464ENST00000264674-1417969_9919311117.0Zinc fingerC2H2-type 10
HgeneMECOMchr3:168810746chr15:44180464ENST00000392736-1316912_9348661052.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:168810746chr15:44180464ENST00000392736-1316940_9638661052.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:168810746chr15:44180464ENST00000392736-1316969_9918661052.0Zinc fingerC2H2-type 10
HgeneMECOMchr3:168810746chr15:44180464ENST00000433243-1417912_9348671053.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:168810746chr15:44180464ENST00000433243-1417940_9638671053.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:168810746chr15:44180464ENST00000433243-1417969_9918671053.0Zinc fingerC2H2-type 10
HgeneMECOMchr3:168810746chr15:44180464ENST00000464456-1215912_9348571043.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:168810746chr15:44180464ENST00000464456-1215940_9638571043.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:168810746chr15:44180464ENST00000464456-1215969_9918571043.0Zinc fingerC2H2-type 10
HgeneMECOMchr3:168810746chr15:44180464ENST00000468789-1316912_9348661052.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:168810746chr15:44180464ENST00000468789-1316940_9638661052.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:168810746chr15:44180464ENST00000468789-1316969_9918661052.0Zinc fingerC2H2-type 10
HgeneMECOMchr3:168810746chr15:44180464ENST00000472280-1316912_9348671053.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:168810746chr15:44180464ENST00000472280-1316940_9638671053.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:168810746chr15:44180464ENST00000472280-1316969_9918671053.0Zinc fingerC2H2-type 10
TgeneFRMD5chr3:168810746chr15:44180464ENST0000041725781417_298264571.0DomainFERM


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Fusion Gene Sequence for MECOM-FRMD5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>52496_52496_1_MECOM-FRMD5_MECOM_chr3_168810746_ENST00000460814_FRMD5_chr15_44180464_ENST00000402883_length(transcript)=5829nt_BP=2686nt
AACATGTTGTTGGAAAGGAAGCTAATAAGTTAAACCTTTGAGAGATGCCAAAAAAAGAGATATTCTATAGAGTAGTTGCAGACATTGCGC
CGGGAGAGGAGCTTCTGCTGTTCATGAAGAGCGAAGACTATCCCCATGAAACTATGGCGCCGGATATCCACGAAGAACGGCAATATCGCT
GCGAAGACTGTGACCAGCTCTTTGAATCTAAGGCTGAACTAGCAGATCACCAAAAGTTTCCATGCAGTACTCCTCACTCAGCATTTTCAA
TGGTTGAAGAGGACTTTCAGCAAAAACTCGAAAGCGAGAATGATCTCCAAGAGATACACACGATCCAGGAGTGTAAGGAATGTGACCAAG
TTTTTCCTGATTTGCAAAGCCTGGAGAAACACATGCTGTCACATACTGAAGAGAGGGAATACAAGTGTGATCAGTGTCCCAAGGCATTTA
ACTGGAAGTCCAATTTAATTCGCCACCAGATGTCACATGACAGTGGAAAGCACTATGAATGTGAAAACTGTGCCAAGGTTTTCACGGACC
CTAGCAACCTTCAGCGGCACATTCGCTCTCAGCATGTCGGTGCCCGGGCCCATGCATGCCCGGAGTGTGGCAAAACGTTTGCCACTTCGT
CGGGCCTCAAACAACACAAGCACATCCACAGCAGTGTGAAGCCCTTTATCTGTGAGGTCTGCCATAAATCCTATACTCAGTTTTCAAACC
TTTGCCGTCATAAGCGCATGCATGCTGATTGCAGAACCCAAATCAAGTGCAAAGACTGTGGACAAATGTTCAGCACTACGTCTTCCTTAA
ATAAACACAGGAGGTTTTGTGAGGGCAAGAACCATTTTGCGGCAGGTGGATTTTTTGGCCAAGGCATTTCACTTCCTGGAACCCCAGCTA
TGGATAAAACGTCCATGGTTAATATGAGTCATGCCAACCCGGGCCTTGCTGACTATTTTGGCGCCAATAGGCATCCTGCTGGTCTTACCT
TTCCAACAGCTCCTGGATTTTCTTTTAGCTTCCCTGGTCTGTTTCCTTCCGGCTTGTACCACAGGCCTCCTTTGATACCTGCTAGTTCTC
CTGTTAAAGGACTATCAAGTACTGAACAGACAAACAAAAGTCAAAGTCCCCTCATGACACATCCTCAGATACTGCCAGCTACACAGGATA
TTTTGAAGGCACTATCTAAACACCCATCTGTAGGGGACAATAAGCCAGTGGAGCTCCAGCCCGAGAGGTCCTCTGAAGAGAGGCCCTTTG
AGAAAATCAGTGACCAGTCAGAGAGTAGTGACCTTGATGATGTCAGTACACCAAGTGGCAGTGACCTGGAAACAACCTCGGGCTCTGATC
TGGAAAGTGACATTGAAAGTGATAAAGAGAAATTTAAAGAAAATGGTAAAATGTTCAAAGACAAAGTAAGCCCTCTTCAGAATCTGGCTT
CAATAAATAATAAGAAAGAATACAGCAATCATTCCATTTTCTCACCATCTTTAGAGGAGCAGACTGCGGTGTCAGGAGCTGTGAATGATT
CTATAAAGGCTATTGCTTCTATTGCTGAAAAATACTTTGGTTCAACAGGACTGGTGGGGCTGCAAGACAAAAAAGTTGGAGCTTTACCTT
ACCCTTCCATGTTTCCCCTCCCATTTTTTCCAGCATTCTCTCAATCAATGTACCCATTTCCTGATAGAGACTTGAGATCGTTACCTTTGA
AAATGGAACCCCAATCACCAGGTGAAGTAAAGAAACTGCAGAAGGGCAGCTCTGAGTCCCCCTTTGATCTCACCACTAAGCGAAAGGATG
AGAAGCCCTTGACTCCAGTCCCCTCCAAGCCTCCAGTGACACCTGCCACAAGCCAAGACCAGCCCCTGGATCTAAGTATGGGCAGTAGGA
GTAGAGCCAGTGGGACAAAGCTGACTGAGCCTCGAAAAAACCACGTGTTTGGGGGAAAAAAAGGAAGCAACGTCGAATCAAGACCTGCTT
CAGATGGTTCCTTGCAGCATGCAAGACCCACTCCTTTCTTTATGGACCCTATTTACAGAGTAGAGAAAAGAAAACTAACTGACCCACTTG
AAGCTTTAAAAGAGAAATACTTGAGGCCTTCTCCAGGATTCTTGTTTCACCCACAAATGTCAGCTATTGAAAACATGGCAGAAAAGCTAG
AGAGCTTCAGTGCCCTGAAACCTGAGGCCAGTGAGCTCTTACAGTCAGTGCCCTCTATGTTCAACTTCAGGGCGCCTCCCAATGCCCTGC
CAGAGAACCTTCTGCGGAAGGGAAAGGAGCGCTATACCTGCAGATACTGTGGCAAGATTTTTCCAAGGTCTGCAAACCTAACACGGCACT
TGAGAACCCACACAGGAGAGCAGCCTTACAGATGCAAATACTGTGACAGATCATTTAGCATATCTTCTAACTTGCAAAGGCATGTTCGCA
ACATCCACAATAAAGAGAAGCCATTTAAGTGTCACTTATGTGATAGGTGTTTTGGTCAACAAACCAATTTAGACAGACACCTAAAGAAAC
ATGAGAATGGGAACATGTCCGGTACAGCAACATCGTCGCCTCATTCTGAACTGGAAAGTACAGGTGCGATTCTGGATGACAAAGAAGATG
CTTACTTCACAGAAATTCGAAATTTCATTGGGAACAGCAACCATGGCAGCCAATCTCCCAGGAATGTGGAGGAGAGGAAAAGAAAATTAT
TCTTACATATTTTGCTCCAACTCCTGAAGCGTGTAAGCACCTCTGGAAATGTGGAATCGAGAACCAAGCCTTCTACAAGCTGGAGAAGTC
AAGCCAAGTCCGCACAGTGTCCAGCAGCAATTTATTCTTTAAAGGGAGCCGGTTCCGATACAGTGGCCGAGTTGCAAAGGAAGTCATGGA
ATCAAGTGCTAAGATCAAACGGGAGCCACCGGAAATACACAGAGCAGGGATGGTTCCCAGCCGGAGCTGTCCCTCCATAACCCATGGCCC
AAGGCTGAGCAGCGTCCCCAGGACCCGCAGAAGAGCTGTTCACATCTCCATCATGGAAGGCCTAGAGTCCTTACGGGACAGTGCCCATTC
CACACCAGTGCGTTCCACTTCCCATGGGGACACCTTCCTGCCTCACGTGAGAAGCAGCCGGACAGATAGCAATGAGCGAGTAGCTGTGAT
TGCAGACGAGGCCTACAGCCCTGCAGACAGCGTGCTGCCCACCCCTGTGGCTGAGCACAGCCTGGAGCTGATGTTGCTTTCCCGGCAGAT
CAATGGAGCCACCTGCAGCATTGAGGAGGAGAAGGAATCTGAAGCCAGCACCCCAACTGCTACAGAGGTGGAGGCCCTTGGGGGAGAGCT
GAGGGCCCTGTGTCAGGGGCACAGCGGGCCCGAGGAGGAACAGAGTGGGCATCTGAAGGGACCACCGCTACAGCAACAGCAGCATCAGGG
GTGGGGTAAGTCTGTCCCCTTAGTCTAGAGCCTAGTGGGCATCACCATAGTTTTGTATAATGAAACTAGACTTAACGTGATTTTTTTTTT
CCGAAGAACCTCAAGACTTTTATAGTGCTCCAGGGGCGTTAAACGAATTCAGTGGTACCAGAGATAGATAGTTCTGTCAGAAATGTTGGA
CAAAGTGTAGTTAAGAGAAAGCAGAGTTAAGTTACCTGAGAGACTGTTGAGATTTGGATAGCAGTGCTTATTTTATATACACCCCCTTGA
CCCAAAGACTATTTCAATTTATATTTTAACAACGAAATGTTATTTTCTTAACAATTCATATTTTGTTTTTACTTTATGGATTAAGAAAAT
AGAGCCTGATGAACTAAACGATGCAAGAAAGAAACTGATCCTGAGAATGAAAAGCTTCAGAAAATAGAATTCCAAGATCAACAGCCTTAG
AAGGGACCAGGAAAAGAATCTTTTAAAATAGATTTCTAAGAGATGCCTACAAAACACAGAATGTGACCGTGGCAGAGACCAACACTTAGA
TGTAGAAATGCTGCCCCCTAGGGTCATCCTCTGCATAAGTTCTAGGAAAGCATCACCATCCTTGCAGAGGGAAGTCCTCGAAGCACGCAG
CACAGGCATATGAAGGGCGAGTGTGGGATCCTAGGCCCAAGCTCTTCAACTCTAAAACCAATCACACACAAGATCCTGTTTTCATCTCAG
GGAGAGATTTCTAAGTCATCTGGGGCTTGAGGGCTTATTTAAGGGTGGTCAATGGACATATTCCTGGACCCACACAAAAGTAGAGCAGCT
GCTGATACCCTAATTGGACAGCCCCAAACGCAGAACAGAACAAGTCACTTGTAGACTTGACCTCCCCTATTTTGTCCCCCGAGATGGTAG
AACCATGTCCATGTTTACAATATGACAACTGTGGAATAATTGGGGTTCTTAGGGAGAGATTTGCATAATTTTAAAGACATCCTTTCATCT
GGACCAGAGGTCAATCAACTTATGTCAAGTGCTACACAGTAAATATTTTGGTTTAGCACGCCATACTGTGTCACAACTGCTCAATTCTGC
CATCACAGCACAAAAACAGCCACAGATAATTTGTAAATGAAGGAACATGGCTGTGTTCCAATAAAACTTTATGAAAACAGTGAGCTGAAT
TTAGCCTACAGGCCATAATACGCCAATCCTGCTCTAGACAATAAAACTGATCCTTACCAGTATGTTAGCAGAAGAGGGTCAGTCAGCTCT
GTTTCCATGCCTGACATGTATCAAAGATCTGGGACCTCTTCCCAGTGGAGGCACTAGGGTTGCTTGTTTAAAGGGTGCTTGAACAACTAA
CCAGCAAAGAGATGTCTGATGCCAAATGGGCAAGATCAAATACTGGAATGCTAAAACACAGCTGGAATCTAAGAAGGGAAGAGGGCTTCT
CTGACCATTTTCATACCAGCAACAATTTAGGCAGAATTATAAACATCTATTTATCGAGTGACAATACAAACCGAAGGAGATCCTAGTAGA
GATTAGGGGTCAGTTAAAATCAACTAGCCACTGCCACTTGTCATCTACATAGCAAAGGCTTTATTTAGCACAGGACTAACGTGAAAAGTA
GACCCAGAGATGAAAAGGCTGTCAGGAGACAGGGGGCTGGTGTCCACCTGGTATCTACTGTCTTATGCAACATAGAAGATTACCTTTTAG
TGTAGTGCTCCTACCTCAGTTTGTAGAATCTGGTGTTTCTATGCAGTGAGTGATAGCCTCAACTCTGACCTTTCATATTCACATTAGAGA
CAGATGCAGTATTCCATATCCTAGTATGTTCCTTGTGTCTAGAGTTCTAACAGTACAGTAGTCTATGCCATTTCTAACAGCTAAATTTTG
CTCTGTAAACAGAAACTTTAGGGTTGTTTTTTTCCAGGGCTCATCCCAGAAAATATGGATAGAAAAGTTTCCTTCAGTTTGCTTTTCAAA
TAGTGCTTGAATAATAAACCTCCTTTGATTGGTGACTAGTCTTTTTTGGTATATCTCCACCTTTAAAAATTGTTCAAGTTTTTAACCTGG
TTATACTGTGTTCTAACATGTCTCTCATTTTCTCTCAAAATTAGTTTATCTCATTGTAGAAAAAGCAATGGTTTTCATAGCTTCATCTAT
CAGGAAATAAAACTCTTACTAAAGAATAGCATACTGCATCTTTAAGCAGTAGAGGGTAAACTACCTGCAAATGTGAATTTCTTAGATACA
TTTAAAAATATATAGTTGTTAACCTTCTGTGTGCCAAAAACTCTTAAGTTACATTTTCCTTCAAAGCAATGTACTTTTTTCTACATATGC

>52496_52496_1_MECOM-FRMD5_MECOM_chr3_168810746_ENST00000460814_FRMD5_chr15_44180464_ENST00000402883_length(amino acids)=971AA_BP=880
MPKKEIFYRVVADIAPGEELLLFMKSEDYPHETMAPDIHEERQYRCEDCDQLFESKAELADHQKFPCSTPHSAFSMVEEDFQQKLESEND
LQEIHTIQECKECDQVFPDLQSLEKHMLSHTEEREYKCDQCPKAFNWKSNLIRHQMSHDSGKHYECENCAKVFTDPSNLQRHIRSQHVGA
RAHACPECGKTFATSSGLKQHKHIHSSVKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFCEGKNHFAA
GGFFGQGISLPGTPAMDKTSMVNMSHANPGLADYFGANRHPAGLTFPTAPGFSFSFPGLFPSGLYHRPPLIPASSPVKGLSSTEQTNKSQ
SPLMTHPQILPATQDILKALSKHPSVGDNKPVELQPERSSEERPFEKISDQSESSDLDDVSTPSGSDLETTSGSDLESDIESDKEKFKEN
GKMFKDKVSPLQNLASINNKKEYSNHSIFSPSLEEQTAVSGAVNDSIKAIASIAEKYFGSTGLVGLQDKKVGALPYPSMFPLPFFPAFSQ
SMYPFPDRDLRSLPLKMEPQSPGEVKKLQKGSSESPFDLTTKRKDEKPLTPVPSKPPVTPATSQDQPLDLSMGSRSRASGTKLTEPRKNH
VFGGKKGSNVESRPASDGSLQHARPTPFFMDPIYRVEKRKLTDPLEALKEKYLRPSPGFLFHPQMSAIENMAEKLESFSALKPEASELLQ
SVPSMFNFRAPPNALPENLLRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRHVRNIHNKEKPFKCHLCD
RCFGQQTNLDRHLKKHENGNMSGTATSSPHSELESTGAILDDKEDAYFTEIRNFIGNSNHGSQSPRNVEERKRKLFLHILLQLLKRVSTS

--------------------------------------------------------------
>52496_52496_2_MECOM-FRMD5_MECOM_chr3_168810746_ENST00000460814_FRMD5_chr15_44180464_ENST00000417257_length(transcript)=6728nt_BP=2686nt
AACATGTTGTTGGAAAGGAAGCTAATAAGTTAAACCTTTGAGAGATGCCAAAAAAAGAGATATTCTATAGAGTAGTTGCAGACATTGCGC
CGGGAGAGGAGCTTCTGCTGTTCATGAAGAGCGAAGACTATCCCCATGAAACTATGGCGCCGGATATCCACGAAGAACGGCAATATCGCT
GCGAAGACTGTGACCAGCTCTTTGAATCTAAGGCTGAACTAGCAGATCACCAAAAGTTTCCATGCAGTACTCCTCACTCAGCATTTTCAA
TGGTTGAAGAGGACTTTCAGCAAAAACTCGAAAGCGAGAATGATCTCCAAGAGATACACACGATCCAGGAGTGTAAGGAATGTGACCAAG
TTTTTCCTGATTTGCAAAGCCTGGAGAAACACATGCTGTCACATACTGAAGAGAGGGAATACAAGTGTGATCAGTGTCCCAAGGCATTTA
ACTGGAAGTCCAATTTAATTCGCCACCAGATGTCACATGACAGTGGAAAGCACTATGAATGTGAAAACTGTGCCAAGGTTTTCACGGACC
CTAGCAACCTTCAGCGGCACATTCGCTCTCAGCATGTCGGTGCCCGGGCCCATGCATGCCCGGAGTGTGGCAAAACGTTTGCCACTTCGT
CGGGCCTCAAACAACACAAGCACATCCACAGCAGTGTGAAGCCCTTTATCTGTGAGGTCTGCCATAAATCCTATACTCAGTTTTCAAACC
TTTGCCGTCATAAGCGCATGCATGCTGATTGCAGAACCCAAATCAAGTGCAAAGACTGTGGACAAATGTTCAGCACTACGTCTTCCTTAA
ATAAACACAGGAGGTTTTGTGAGGGCAAGAACCATTTTGCGGCAGGTGGATTTTTTGGCCAAGGCATTTCACTTCCTGGAACCCCAGCTA
TGGATAAAACGTCCATGGTTAATATGAGTCATGCCAACCCGGGCCTTGCTGACTATTTTGGCGCCAATAGGCATCCTGCTGGTCTTACCT
TTCCAACAGCTCCTGGATTTTCTTTTAGCTTCCCTGGTCTGTTTCCTTCCGGCTTGTACCACAGGCCTCCTTTGATACCTGCTAGTTCTC
CTGTTAAAGGACTATCAAGTACTGAACAGACAAACAAAAGTCAAAGTCCCCTCATGACACATCCTCAGATACTGCCAGCTACACAGGATA
TTTTGAAGGCACTATCTAAACACCCATCTGTAGGGGACAATAAGCCAGTGGAGCTCCAGCCCGAGAGGTCCTCTGAAGAGAGGCCCTTTG
AGAAAATCAGTGACCAGTCAGAGAGTAGTGACCTTGATGATGTCAGTACACCAAGTGGCAGTGACCTGGAAACAACCTCGGGCTCTGATC
TGGAAAGTGACATTGAAAGTGATAAAGAGAAATTTAAAGAAAATGGTAAAATGTTCAAAGACAAAGTAAGCCCTCTTCAGAATCTGGCTT
CAATAAATAATAAGAAAGAATACAGCAATCATTCCATTTTCTCACCATCTTTAGAGGAGCAGACTGCGGTGTCAGGAGCTGTGAATGATT
CTATAAAGGCTATTGCTTCTATTGCTGAAAAATACTTTGGTTCAACAGGACTGGTGGGGCTGCAAGACAAAAAAGTTGGAGCTTTACCTT
ACCCTTCCATGTTTCCCCTCCCATTTTTTCCAGCATTCTCTCAATCAATGTACCCATTTCCTGATAGAGACTTGAGATCGTTACCTTTGA
AAATGGAACCCCAATCACCAGGTGAAGTAAAGAAACTGCAGAAGGGCAGCTCTGAGTCCCCCTTTGATCTCACCACTAAGCGAAAGGATG
AGAAGCCCTTGACTCCAGTCCCCTCCAAGCCTCCAGTGACACCTGCCACAAGCCAAGACCAGCCCCTGGATCTAAGTATGGGCAGTAGGA
GTAGAGCCAGTGGGACAAAGCTGACTGAGCCTCGAAAAAACCACGTGTTTGGGGGAAAAAAAGGAAGCAACGTCGAATCAAGACCTGCTT
CAGATGGTTCCTTGCAGCATGCAAGACCCACTCCTTTCTTTATGGACCCTATTTACAGAGTAGAGAAAAGAAAACTAACTGACCCACTTG
AAGCTTTAAAAGAGAAATACTTGAGGCCTTCTCCAGGATTCTTGTTTCACCCACAAATGTCAGCTATTGAAAACATGGCAGAAAAGCTAG
AGAGCTTCAGTGCCCTGAAACCTGAGGCCAGTGAGCTCTTACAGTCAGTGCCCTCTATGTTCAACTTCAGGGCGCCTCCCAATGCCCTGC
CAGAGAACCTTCTGCGGAAGGGAAAGGAGCGCTATACCTGCAGATACTGTGGCAAGATTTTTCCAAGGTCTGCAAACCTAACACGGCACT
TGAGAACCCACACAGGAGAGCAGCCTTACAGATGCAAATACTGTGACAGATCATTTAGCATATCTTCTAACTTGCAAAGGCATGTTCGCA
ACATCCACAATAAAGAGAAGCCATTTAAGTGTCACTTATGTGATAGGTGTTTTGGTCAACAAACCAATTTAGACAGACACCTAAAGAAAC
ATGAGAATGGGAACATGTCCGGTACAGCAACATCGTCGCCTCATTCTGAACTGGAAAGTACAGGTGCGATTCTGGATGACAAAGAAGATG
CTTACTTCACAGAAATTCGAAATTTCATTGGGAACAGCAACCATGGCAGCCAATCTCCCAGGAATGTGGAGGAGAGGAAAAGAAAATTAT
TCTTACATATTTTGCTCCAACTCCTGAAGCGTGTAAGCACCTCTGGAAATGTGGAATCGAGAACCAAGCCTTCTACAAGCTGGAGAAGTC
AAGCCAAGTCCGCACAGTGTCCAGCAGCAATTTATTCTTTAAAGGGAGCCGGTTCCGATACAGTGGCCGAGTTGCAAAGGAAGTCATGGA
ATCAAGTGCTAAGATCAAACGGGAGCCACCGGAAATACACAGAGCAGGGATGGTTCCCAGCCGGAGCTGTCCCTCCATAACCCATGGCCC
AAGGCTGAGCAGCGTCCCCAGGACCCGCAGAAGAGCTGTTCACATCTCCATCATGGAAGGCCTAGAGTCCTTACGGGACAGTGCCCATTC
CACACCAGTGCGTTCCACTTCCCATGGGGACACCTTCCTGCCTCACGTGAGAAGCAGCCGGACAGATAGCAATGAGCGAGTAGCTGTGAT
TGCAGACGAGGCCTACAGCCCTGCAGACAGCGTGCTGCCCACCCCTGTGGCTGAGCACAGCCTGGAGCTGATGTTGCTTTCCCGGCAGAT
CAATGGAGCCACCTGCAGCATTGAGGAGGAGAAGGAATCTGAAGCCAGCACCCCAACTGCTACAGAGGTGGAGGCCCTTGGGGGAGAGCT
GAGGGCCCTGTGTCAGGGGCACAGCGGGCCCGAGGAGGAACAGGTGAATAAGTTTGTTCTAAGTGTCCTCCGTTTGCTCCTTGTGACCAT
GGGACTCCTCTTTGTTTTGCTCCTCCTCCTGATCATCCTTACCGAGTCTGACCTTGACATTGCCTTTTTCCGTGATATCCGCCAGACCCC
CGAGTTTGAACAATTCCACTATCAATACTTTTGTCCCCTCAGGCGATGGTTTGCCTGCAAAATCCGCTCAGTGGTGAGCCTGCTCATTGA
CACCTGAGAAGGCATGACTCCTCCCAAAAACTAGCCAGGTGGACCAAGGAACCCGGCTACCCATTCCCAGCAATGGGACCCATCGCGGAA
CCATCGGCACATATACCAAGTCCTCCTCTCATGACTCAAAGTCCACTGCAGCCTAGGAGGGTGTTTCCCAGAAGAAGAAAGGGATAGGCT
CATGCCCTGTCTAAACAAACTGGGAAAACTCATTTTCTTCAGAAGTTATTTCAAGAAAGGCTCAGCGACTCTGTTTCTCATCTTTCCAAT
TTGCAGGATAATTTTTGGTTTTGAATTTTGATTTTTCATAGATGTATATTATTTTGAAGTATCAAATAAAAATAATTTATTTTACTATTA
CTGATTATTGCAGTAGTATCACCTAGCAGAGGGGACACTAGTTGAAAACTAGAGAGCTGCTGTCCTCTGTATTCTGCAGGAGCTTTTCCT
GCTGGTGCCACTGGGTTCCAGTAGACTCATCACTGCAGCCTCAGCAGGGCAGGCCAGGGATCTGGACAATGGGGACTGTTTAGTTTTTTG
TTTGTTTTTTTTGCCAGCCAGAACTTTTAAAAAAGTAAACATCCATGTAGAATGATTAAATGGAAAGTTGCTTCTTATGATGGTCTGAGT
TGGATTTTCTTTTCCTTTTGTTTTTTCAAATCTGAGCAGAGTGGGCATCTGAAGGGACCACCGCTACAGCAACAGCAGCATCAGGGGTGG
GGTAAGTCTGTCCCCTTAGTCTAGAGCCTAGTGGGCATCACCATAGTTTTGTATAATGAAACTAGACTTAACGTGATTTTTTTTTTCCGA
AGAACCTCAAGACTTTTATAGTGCTCCAGGGGCGTTAAACGAATTCAGTGGTACCAGAGATAGATAGTTCTGTCAGAAATGTTGGACAAA
GTGTAGTTAAGAGAAAGCAGAGTTAAGTTACCTGAGAGACTGTTGAGATTTGGATAGCAGTGCTTATTTTATATACACCCCCTTGACCCA
AAGACTATTTCAATTTATATTTTAACAACGAAATGTTATTTTCTTAACAATTCATATTTTGTTTTTACTTTATGGATTAAGAAAATAGAG
CCTGATGAACTAAACGATGCAAGAAAGAAACTGATCCTGAGAATGAAAAGCTTCAGAAAATAGAATTCCAAGATCAACAGCCTTAGAAGG
GACCAGGAAAAGAATCTTTTAAAATAGATTTCTAAGAGATGCCTACAAAACACAGAATGTGACCGTGGCAGAGACCAACACTTAGATGTA
GAAATGCTGCCCCCTAGGGTCATCCTCTGCATAAGTTCTAGGAAAGCATCACCATCCTTGCAGAGGGAAGTCCTCGAAGCACGCAGCACA
GGCATATGAAGGGCGAGTGTGGGATCCTAGGCCCAAGCTCTTCAACTCTAAAACCAATCACACACAAGATCCTGTTTTCATCTCAGGGAG
AGATTTCTAAGTCATCTGGGGCTTGAGGGCTTATTTAAGGGTGGTCAATGGACATATTCCTGGACCCACACAAAAGTAGAGCAGCTGCTG
ATACCCTAATTGGACAGCCCCAAACGCAGAACAGAACAAGTCACTTGTAGACTTGACCTCCCCTATTTTGTCCCCCGAGATGGTAGAACC
ATGTCCATGTTTACAATATGACAACTGTGGAATAATTGGGGTTCTTAGGGAGAGATTTGCATAATTTTAAAGACATCCTTTCATCTGGAC
CAGAGGTCAATCAACTTATGTCAAGTGCTACACAGTAAATATTTTGGTTTAGCACGCCATACTGTGTCACAACTGCTCAATTCTGCCATC
ACAGCACAAAAACAGCCACAGATAATTTGTAAATGAAGGAACATGGCTGTGTTCCAATAAAACTTTATGAAAACAGTGAGCTGAATTTAG
CCTACAGGCCATAATACGCCAATCCTGCTCTAGACAATAAAACTGATCCTTACCAGTATGTTAGCAGAAGAGGGTCAGTCAGCTCTGTTT
CCATGCCTGACATGTATCAAAGATCTGGGACCTCTTCCCAGTGGAGGCACTAGGGTTGCTTGTTTAAAGGGTGCTTGAACAACTAACCAG
CAAAGAGATGTCTGATGCCAAATGGGCAAGATCAAATACTGGAATGCTAAAACACAGCTGGAATCTAAGAAGGGAAGAGGGCTTCTCTGA
CCATTTTCATACCAGCAACAATTTAGGCAGAATTATAAACATCTATTTATCGAGTGACAATACAAACCGAAGGAGATCCTAGTAGAGATT
AGGGGTCAGTTAAAATCAACTAGCCACTGCCACTTGTCATCTACATAGCAAAGGCTTTATTTAGCACAGGACTAACGTGAAAAGTAGACC
CAGAGATGAAAAGGCTGTCAGGAGACAGGGGGCTGGTGTCCACCTGGTATCTACTGTCTTATGCAACATAGAAGATTACCTTTTAGTGTA
GTGCTCCTACCTCAGTTTGTAGAATCTGGTGTTTCTATGCAGTGAGTGATAGCCTCAACTCTGACCTTTCATATTCACATTAGAGACAGA
TGCAGTATTCCATATCCTAGTATGTTCCTTGTGTCTAGAGTTCTAACAGTACAGTAGTCTATGCCATTTCTAACAGCTAAATTTTGCTCT
GTAAACAGAAACTTTAGGGTTGTTTTTTTCCAGGGCTCATCCCAGAAAATATGGATAGAAAAGTTTCCTTCAGTTTGCTTTTCAAATAGT
GCTTGAATAATAAACCTCCTTTGATTGGTGACTAGTCTTTTTTGGTATATCTCCACCTTTAAAAATTGTTCAAGTTTTTAACCTGGTTAT
ACTGTGTTCTAACATGTCTCTCATTTTCTCTCAAAATTAGTTTATCTCATTGTAGAAAAAGCAATGGTTTTCATAGCTTCATCTATCAGG
AAATAAAACTCTTACTAAAGAATAGCATACTGCATCTTTAAGCAGTAGAGGGTAAACTACCTGCAAATGTGAATTTCTTAGATACATTTA
AAAATATATAGTTGTTAACCTTCTGTGTGCCAAAAACTCTTAAGTTACATTTTCCTTCAAAGCAATGTACTTTTTTCTACATATGCAGTA

>52496_52496_2_MECOM-FRMD5_MECOM_chr3_168810746_ENST00000460814_FRMD5_chr15_44180464_ENST00000417257_length(amino acids)=971AA_BP=880
MPKKEIFYRVVADIAPGEELLLFMKSEDYPHETMAPDIHEERQYRCEDCDQLFESKAELADHQKFPCSTPHSAFSMVEEDFQQKLESEND
LQEIHTIQECKECDQVFPDLQSLEKHMLSHTEEREYKCDQCPKAFNWKSNLIRHQMSHDSGKHYECENCAKVFTDPSNLQRHIRSQHVGA
RAHACPECGKTFATSSGLKQHKHIHSSVKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFCEGKNHFAA
GGFFGQGISLPGTPAMDKTSMVNMSHANPGLADYFGANRHPAGLTFPTAPGFSFSFPGLFPSGLYHRPPLIPASSPVKGLSSTEQTNKSQ
SPLMTHPQILPATQDILKALSKHPSVGDNKPVELQPERSSEERPFEKISDQSESSDLDDVSTPSGSDLETTSGSDLESDIESDKEKFKEN
GKMFKDKVSPLQNLASINNKKEYSNHSIFSPSLEEQTAVSGAVNDSIKAIASIAEKYFGSTGLVGLQDKKVGALPYPSMFPLPFFPAFSQ
SMYPFPDRDLRSLPLKMEPQSPGEVKKLQKGSSESPFDLTTKRKDEKPLTPVPSKPPVTPATSQDQPLDLSMGSRSRASGTKLTEPRKNH
VFGGKKGSNVESRPASDGSLQHARPTPFFMDPIYRVEKRKLTDPLEALKEKYLRPSPGFLFHPQMSAIENMAEKLESFSALKPEASELLQ
SVPSMFNFRAPPNALPENLLRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRHVRNIHNKEKPFKCHLCD
RCFGQQTNLDRHLKKHENGNMSGTATSSPHSELESTGAILDDKEDAYFTEIRNFIGNSNHGSQSPRNVEERKRKLFLHILLQLLKRVSTS

--------------------------------------------------------------
>52496_52496_3_MECOM-FRMD5_MECOM_chr3_168810746_ENST00000460814_FRMD5_chr15_44180464_ENST00000484674_length(transcript)=4038nt_BP=2686nt
AACATGTTGTTGGAAAGGAAGCTAATAAGTTAAACCTTTGAGAGATGCCAAAAAAAGAGATATTCTATAGAGTAGTTGCAGACATTGCGC
CGGGAGAGGAGCTTCTGCTGTTCATGAAGAGCGAAGACTATCCCCATGAAACTATGGCGCCGGATATCCACGAAGAACGGCAATATCGCT
GCGAAGACTGTGACCAGCTCTTTGAATCTAAGGCTGAACTAGCAGATCACCAAAAGTTTCCATGCAGTACTCCTCACTCAGCATTTTCAA
TGGTTGAAGAGGACTTTCAGCAAAAACTCGAAAGCGAGAATGATCTCCAAGAGATACACACGATCCAGGAGTGTAAGGAATGTGACCAAG
TTTTTCCTGATTTGCAAAGCCTGGAGAAACACATGCTGTCACATACTGAAGAGAGGGAATACAAGTGTGATCAGTGTCCCAAGGCATTTA
ACTGGAAGTCCAATTTAATTCGCCACCAGATGTCACATGACAGTGGAAAGCACTATGAATGTGAAAACTGTGCCAAGGTTTTCACGGACC
CTAGCAACCTTCAGCGGCACATTCGCTCTCAGCATGTCGGTGCCCGGGCCCATGCATGCCCGGAGTGTGGCAAAACGTTTGCCACTTCGT
CGGGCCTCAAACAACACAAGCACATCCACAGCAGTGTGAAGCCCTTTATCTGTGAGGTCTGCCATAAATCCTATACTCAGTTTTCAAACC
TTTGCCGTCATAAGCGCATGCATGCTGATTGCAGAACCCAAATCAAGTGCAAAGACTGTGGACAAATGTTCAGCACTACGTCTTCCTTAA
ATAAACACAGGAGGTTTTGTGAGGGCAAGAACCATTTTGCGGCAGGTGGATTTTTTGGCCAAGGCATTTCACTTCCTGGAACCCCAGCTA
TGGATAAAACGTCCATGGTTAATATGAGTCATGCCAACCCGGGCCTTGCTGACTATTTTGGCGCCAATAGGCATCCTGCTGGTCTTACCT
TTCCAACAGCTCCTGGATTTTCTTTTAGCTTCCCTGGTCTGTTTCCTTCCGGCTTGTACCACAGGCCTCCTTTGATACCTGCTAGTTCTC
CTGTTAAAGGACTATCAAGTACTGAACAGACAAACAAAAGTCAAAGTCCCCTCATGACACATCCTCAGATACTGCCAGCTACACAGGATA
TTTTGAAGGCACTATCTAAACACCCATCTGTAGGGGACAATAAGCCAGTGGAGCTCCAGCCCGAGAGGTCCTCTGAAGAGAGGCCCTTTG
AGAAAATCAGTGACCAGTCAGAGAGTAGTGACCTTGATGATGTCAGTACACCAAGTGGCAGTGACCTGGAAACAACCTCGGGCTCTGATC
TGGAAAGTGACATTGAAAGTGATAAAGAGAAATTTAAAGAAAATGGTAAAATGTTCAAAGACAAAGTAAGCCCTCTTCAGAATCTGGCTT
CAATAAATAATAAGAAAGAATACAGCAATCATTCCATTTTCTCACCATCTTTAGAGGAGCAGACTGCGGTGTCAGGAGCTGTGAATGATT
CTATAAAGGCTATTGCTTCTATTGCTGAAAAATACTTTGGTTCAACAGGACTGGTGGGGCTGCAAGACAAAAAAGTTGGAGCTTTACCTT
ACCCTTCCATGTTTCCCCTCCCATTTTTTCCAGCATTCTCTCAATCAATGTACCCATTTCCTGATAGAGACTTGAGATCGTTACCTTTGA
AAATGGAACCCCAATCACCAGGTGAAGTAAAGAAACTGCAGAAGGGCAGCTCTGAGTCCCCCTTTGATCTCACCACTAAGCGAAAGGATG
AGAAGCCCTTGACTCCAGTCCCCTCCAAGCCTCCAGTGACACCTGCCACAAGCCAAGACCAGCCCCTGGATCTAAGTATGGGCAGTAGGA
GTAGAGCCAGTGGGACAAAGCTGACTGAGCCTCGAAAAAACCACGTGTTTGGGGGAAAAAAAGGAAGCAACGTCGAATCAAGACCTGCTT
CAGATGGTTCCTTGCAGCATGCAAGACCCACTCCTTTCTTTATGGACCCTATTTACAGAGTAGAGAAAAGAAAACTAACTGACCCACTTG
AAGCTTTAAAAGAGAAATACTTGAGGCCTTCTCCAGGATTCTTGTTTCACCCACAAATGTCAGCTATTGAAAACATGGCAGAAAAGCTAG
AGAGCTTCAGTGCCCTGAAACCTGAGGCCAGTGAGCTCTTACAGTCAGTGCCCTCTATGTTCAACTTCAGGGCGCCTCCCAATGCCCTGC
CAGAGAACCTTCTGCGGAAGGGAAAGGAGCGCTATACCTGCAGATACTGTGGCAAGATTTTTCCAAGGTCTGCAAACCTAACACGGCACT
TGAGAACCCACACAGGAGAGCAGCCTTACAGATGCAAATACTGTGACAGATCATTTAGCATATCTTCTAACTTGCAAAGGCATGTTCGCA
ACATCCACAATAAAGAGAAGCCATTTAAGTGTCACTTATGTGATAGGTGTTTTGGTCAACAAACCAATTTAGACAGACACCTAAAGAAAC
ATGAGAATGGGAACATGTCCGGTACAGCAACATCGTCGCCTCATTCTGAACTGGAAAGTACAGGTGCGATTCTGGATGACAAAGAAGATG
CTTACTTCACAGAAATTCGAAATTTCATTGGGAACAGCAACCATGGCAGCCAATCTCCCAGGAATGTGGAGGAGAGGAAAAGAAAATTAT
TCTTACATATTTTGCTCCAACTCCTGAAGCGTGTAAGCACCTCTGGAAATGTGGAATCGAGAACCAAGCCTTCTACAAGCTGGAGAAGTC
AAGCCAAGTCCGCACAGTGTCCAGCAGCAATTTATTCTTTAAAGGGAGCCGGTTCCGATACAGTGGCCGAGTTGCAAAGGAAGTCATGGA
ATCAAGTGCTAAGATCAAACGGGAGCCACCGGAAATACACAGAGCAGGGATGGTTCCCAGCCGGAGCTGTCCCTCCATAACCCATGGCCC
AAGGCTGAGCAGCGTCCCCAGGACCCGCAGAAGAGCTGTTCACATCTCCATCATGGAAGGCCTAGAGTCCTTACGGGACAGTGCCCATTC
CACACCAGTGCGTTCCACTTCCCATGGGGACACCTTCCTGCCTCACGTGAGAAGCAGCCGGACAGATAGCAATGAGCGAGTAGCTGTGAT
TGCAGACGAGGCCTACAGCCCTGCAGACAGCGTGCTGCCCACCCCTGTGGCTGAGCACAGCCTGGAGCTGATGTTGCTTTCCCGGCAGAT
CAATGGAGCCACCTGCAGCATTGAGGAGGAGAAGGAATCTGAAGCCAGCACCCCAACTGCTACAGAGGTGGAGGCCCTTGGGGGAGAGCT
GAGGGCCCTGTGTCAGGGGCACAGCGGGCCCGAGGAGGAACAGGCGATGGTTTGCCTGCAAAATCCGCTCAGTGGTGAGCCTGCTCATTG
ACACCTGAGAAGGCATGACTCCTCCCAAAAACTAGCCAGGTGGACCAAGGAACCCGGCTACCCATTCCCAGCAATGGGACCCATCGCGGA
ACCATCGGCACATATACCAAGTCCTCCTCTCATGACTCAAAGTCCACTGCAGCCTAGGAGGGTGTTTCCCAGAAGAAGAAAGGGATAGGC
TCATGCCCTGTCTAAACAAACTGGGAAAACTCATTTTCTTCAGAAGTTATTTCAAGAAAGGCTCAGCGACTCTGTTTCTCATCTTTCCAA
TTTGCAGGATAATTTTTGGTTTTGAATTTTGATTTTTCATAGATGTATATTATTTTGAAGTATCAAATAAAAATAATTTATTTTACTATT
ACTGATTATTGCAGTAGTATCACCTAGCAGAGGGGACACTAGTTGAAAACTAGAGAGCTGCTGTCCTCTGTATTCTGCAGGAGCTTTTCC
TGCTGGTGCCACTGGGTTCCAGTAGACTCATCACTGCAGCCTCAGCAGGGCAGGCCAGGGATCTGGACAATGGGGACTGTTTAGTTTTTT

>52496_52496_3_MECOM-FRMD5_MECOM_chr3_168810746_ENST00000460814_FRMD5_chr15_44180464_ENST00000484674_length(amino acids)=971AA_BP=880
MPKKEIFYRVVADIAPGEELLLFMKSEDYPHETMAPDIHEERQYRCEDCDQLFESKAELADHQKFPCSTPHSAFSMVEEDFQQKLESEND
LQEIHTIQECKECDQVFPDLQSLEKHMLSHTEEREYKCDQCPKAFNWKSNLIRHQMSHDSGKHYECENCAKVFTDPSNLQRHIRSQHVGA
RAHACPECGKTFATSSGLKQHKHIHSSVKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFCEGKNHFAA
GGFFGQGISLPGTPAMDKTSMVNMSHANPGLADYFGANRHPAGLTFPTAPGFSFSFPGLFPSGLYHRPPLIPASSPVKGLSSTEQTNKSQ
SPLMTHPQILPATQDILKALSKHPSVGDNKPVELQPERSSEERPFEKISDQSESSDLDDVSTPSGSDLETTSGSDLESDIESDKEKFKEN
GKMFKDKVSPLQNLASINNKKEYSNHSIFSPSLEEQTAVSGAVNDSIKAIASIAEKYFGSTGLVGLQDKKVGALPYPSMFPLPFFPAFSQ
SMYPFPDRDLRSLPLKMEPQSPGEVKKLQKGSSESPFDLTTKRKDEKPLTPVPSKPPVTPATSQDQPLDLSMGSRSRASGTKLTEPRKNH
VFGGKKGSNVESRPASDGSLQHARPTPFFMDPIYRVEKRKLTDPLEALKEKYLRPSPGFLFHPQMSAIENMAEKLESFSALKPEASELLQ
SVPSMFNFRAPPNALPENLLRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRHVRNIHNKEKPFKCHLCD
RCFGQQTNLDRHLKKHENGNMSGTATSSPHSELESTGAILDDKEDAYFTEIRNFIGNSNHGSQSPRNVEERKRKLFLHILLQLLKRVSTS

--------------------------------------------------------------
>52496_52496_4_MECOM-FRMD5_MECOM_chr3_168810746_ENST00000464456_FRMD5_chr15_44180464_ENST00000402883_length(transcript)=6917nt_BP=3774nt
CACACACACACACACACACCACACTTGTGCTTTCAAGACATCGAAACGGAGGCTATTTCCCTGGGGAAAGAAATCCTGCCTGGCGAGATC
TCCCCATTGGTTGTTTACCCGGAGAAATCTACATGTTTAAGGGGGATGGTGCATCCATAATCAGTCTGTCCCTATAGGACTTGGGTCTTG
GCGACCTTTTTGTGACCTCTCCCGCCAGAGGAGGCTGCTGTCACTTTAAAAATTTAAAAGAGGAGCCCGTCTGGCTTCCGATCAGATCAC
TCTGGGCGGCGGGAGATAGCTCCCTTTCTCCCTCGCCCCGGGTTCTTTCTGGATGGCCGAGCAGATCCTCTTTAAAGAGACAGTTCATGA
AATAGAAACCCGGCGGCTGAGCTTGGAGTTGCGAAAGGGGACGATCCCGTGAGGGTCCAGGACCCGCGAAGGCGCTGCGGAGGATCTGAA
AGGGGGATAGAGCTCCCCTCGCCTCCCCAGGCCCCCCACCTTTTCAAACTCTCCTCCTCCTGCTTGTTTTCCCCCATTGGAACTGGGAAG
GAGAAGTAGAAGTTTTAGTGGGTTTCAGATAACTTTCATTACACATCGGGCTGATAAGAGCAAGAGAAAGTGAGAAAAGAGGGAGGTGAT
GTGAACCAGAAGGAATAGCTCCGAGCTCATTTAGGAAGGGGGAAAAAGCCAAAACACACCAAACCCGGGTCACCCAGACGAAAGAAGACT
TCATTTCTTGTATTAAAAATACACTGTTGGCGGACAATAAATCCGAAACGCGTGGTCCTGGAGAGCAGATCCTAGAGACGGACAAAGTTG
TCAGAGACCCATTTGGAAATCGAGACGCGAGGCTTTTAAAAAATTATTATTATTATTTTTAAACATCTCTAAATGTTGCTCGGGATCGTT
TGAAAGGATTTTCGTGCAGGAGCGTTGGGGGCTGCTGATTATTTTATTTTGTTTATTTTGATTCTTCTGTGAATGCCTATTATTGCTGAG
TTGAGGCCATAGAAATCTAAAGATCTTAGACGAATTTTACAATGTGAAGTTCTGCATAGATGCCAGTCAACCAGATGTTGGAAGCTGGCT
CAAGTACATTAGATTCGCTGGCTGTTATGATCAGCACAACCTTGTTGCATGCCAGATAAATGATCAGATATTCTATAGAGTAGTTGCAGA
CATTGCGCCGGGAGAGGAGCTTCTGCTGTTCATGAAGAGCGAAGACTATCCCCATGAAACTATGGCGCCGGATATCCACGAAGAACGGCA
ATATCGCTGCGAAGACTGTGACCAGCTCTTTGAATCTAAGGCTGAACTAGCAGATCACCAAAAGTTTCCATGCAGTACTCCTCACTCAGC
ATTTTCAATGGTTGAAGAGGACTTTCAGCAAAAACTCGAAAGCGAGAATGATCTCCAAGAGATACACACGATCCAGGAGTGTAAGGAATG
TGACCAAGTTTTTCCTGATTTGCAAAGCCTGGAGAAACACATGCTGTCACATACTGAAGAGAGGGAATACAAGTGTGATCAGTGTCCCAA
GGCATTTAACTGGAAGTCCAATTTAATTCGCCACCAGATGTCACATGACAGTGGAAAGCACTATGAATGTGAAAACTGTGCCAAGGTTTT
CACGGACCCTAGCAACCTTCAGCGGCACATTCGCTCTCAGCATGTCGGTGCCCGGGCCCATGCATGCCCGGAGTGTGGCAAAACGTTTGC
CACTTCGTCGGGCCTCAAACAACACAAGCACATCCACAGCAGTGTGAAGCCCTTTATCTGTGAGGTCTGCCATAAATCCTATACTCAGTT
TTCAAACCTTTGCCGTCATAAGCGCATGCATGCTGATTGCAGAACCCAAATCAAGTGCAAAGACTGTGGACAAATGTTCAGCACTACGTC
TTCCTTAAATAAACACAGGAGGTTTTGTGAGGGCAAGAACCATTTTGCGGCAGGTGGATTTTTTGGCCAAGGCATTTCACTTCCTGGAAC
CCCAGCTATGGATAAAACGTCCATGGTTAATATGAGTCATGCCAACCCGGGCCTTGCTGACTATTTTGGCGCCAATAGGCATCCTGCTGG
TCTTACCTTTCCAACAGCTCCTGGATTTTCTTTTAGCTTCCCTGGTCTGTTTCCTTCCGGCTTGTACCACAGGCCTCCTTTGATACCTGC
TAGTTCTCCTGTTAAAGGACTATCAAGTACTGAACAGACAAACAAAAGTCAAAGTCCCCTCATGACACATCCTCAGATACTGCCAGCTAC
ACAGGATATTTTGAAGGCACTATCTAAACACCCATCTGTAGGGGACAATAAGCCAGTGGAGCTCCAGCCCGAGAGGTCCTCTGAAGAGAG
GCCCTTTGAGAAAATCAGTGACCAGTCAGAGAGTAGTGACCTTGATGATGTCAGTACACCAAGTGGCAGTGACCTGGAAACAACCTCGGG
CTCTGATCTGGAAAGTGACATTGAAAGTGATAAAGAGAAATTTAAAGAAAATGGTAAAATGTTCAAAGACAAAGTAAGCCCTCTTCAGAA
TCTGGCTTCAATAAATAATAAGAAAGAATACAGCAATCATTCCATTTTCTCACCATCTTTAGAGGAGCAGACTGCGGTGTCAGGAGCTGT
GAATGATTCTATAAAGGCTATTGCTTCTATTGCTGAAAAATACTTTGGTTCAACAGGACTGGTGGGGCTGCAAGACAAAAAAGTTGGAGC
TTTACCTTACCCTTCCATGTTTCCCCTCCCATTTTTTCCAGCATTCTCTCAATCAATGTACCCATTTCCTGATAGAGACTTGAGATCGTT
ACCTTTGAAAATGGAACCCCAATCACCAGGTGAAGTAAAGAAACTGCAGAAGGGCAGCTCTGAGTCCCCCTTTGATCTCACCACTAAGCG
AAAGGATGAGAAGCCCTTGACTCCAGTCCCCTCCAAGCCTCCAGTGACACCTGCCACAAGCCAAGACCAGCCCCTGGATCTAAGTATGGG
CAGTAGGAGTAGAGCCAGTGGGACAAAGCTGACTGAGCCTCGAAAAAACCACGTGTTTGGGGGAAAAAAAGGAAGCAACGTCGAATCAAG
ACCTGCTTCAGATGGTTCCTTGCAGCATGCAAGACCCACTCCTTTCTTTATGGACCCTATTTACAGAGTAGAGAAAAGAAAACTAACTGA
CCCACTTGAAGCTTTAAAAGAGAAATACTTGAGGCCTTCTCCAGGATTCTTGTTTCACCCACAAATGTCAGCTATTGAAAACATGGCAGA
AAAGCTAGAGAGCTTCAGTGCCCTGAAACCTGAGGCCAGTGAGCTCTTACAGTCAGTGCCCTCTATGTTCAACTTCAGGGCGCCTCCCAA
TGCCCTGCCAGAGAACCTTCTGCGGAAGGGAAAGGAGCGCTATACCTGCAGATACTGTGGCAAGATTTTTCCAAGGTCTGCAAACCTAAC
ACGGCACTTGAGAACCCACACAGGAGAGCAGCCTTACAGATGCAAATACTGTGACAGATCATTTAGCATATCTTCTAACTTGCAAAGGCA
TGTTCGCAACATCCACAATAAAGAGAAGCCATTTAAGTGTCACTTATGTGATAGGTGTTTTGGTCAACAAACCAATTTAGACAGACACCT
AAAGAAACATGAGAATGGGAACATGTCCGGTACAGCAACATCGTCGCCTCATTCTGAACTGGAAAGTACAGGTGCGATTCTGGATGACAA
AGAAGATGCTTACTTCACAGAAATTCGAAATTTCATTGGGAACAGCAACCATGGCAGCCAATCTCCCAGGAATGTGGAGGAGAGGAAAAG
AAAATTATTCTTACATATTTTGCTCCAACTCCTGAAGCGTGTAAGCACCTCTGGAAATGTGGAATCGAGAACCAAGCCTTCTACAAGCTG
GAGAAGTCAAGCCAAGTCCGCACAGTGTCCAGCAGCAATTTATTCTTTAAAGGGAGCCGGTTCCGATACAGTGGCCGAGTTGCAAAGGAA
GTCATGGAATCAAGTGCTAAGATCAAACGGGAGCCACCGGAAATACACAGAGCAGGGATGGTTCCCAGCCGGAGCTGTCCCTCCATAACC
CATGGCCCAAGGCTGAGCAGCGTCCCCAGGACCCGCAGAAGAGCTGTTCACATCTCCATCATGGAAGGCCTAGAGTCCTTACGGGACAGT
GCCCATTCCACACCAGTGCGTTCCACTTCCCATGGGGACACCTTCCTGCCTCACGTGAGAAGCAGCCGGACAGATAGCAATGAGCGAGTA
GCTGTGATTGCAGACGAGGCCTACAGCCCTGCAGACAGCGTGCTGCCCACCCCTGTGGCTGAGCACAGCCTGGAGCTGATGTTGCTTTCC
CGGCAGATCAATGGAGCCACCTGCAGCATTGAGGAGGAGAAGGAATCTGAAGCCAGCACCCCAACTGCTACAGAGGTGGAGGCCCTTGGG
GGAGAGCTGAGGGCCCTGTGTCAGGGGCACAGCGGGCCCGAGGAGGAACAGAGTGGGCATCTGAAGGGACCACCGCTACAGCAACAGCAG
CATCAGGGGTGGGGTAAGTCTGTCCCCTTAGTCTAGAGCCTAGTGGGCATCACCATAGTTTTGTATAATGAAACTAGACTTAACGTGATT
TTTTTTTTCCGAAGAACCTCAAGACTTTTATAGTGCTCCAGGGGCGTTAAACGAATTCAGTGGTACCAGAGATAGATAGTTCTGTCAGAA
ATGTTGGACAAAGTGTAGTTAAGAGAAAGCAGAGTTAAGTTACCTGAGAGACTGTTGAGATTTGGATAGCAGTGCTTATTTTATATACAC
CCCCTTGACCCAAAGACTATTTCAATTTATATTTTAACAACGAAATGTTATTTTCTTAACAATTCATATTTTGTTTTTACTTTATGGATT
AAGAAAATAGAGCCTGATGAACTAAACGATGCAAGAAAGAAACTGATCCTGAGAATGAAAAGCTTCAGAAAATAGAATTCCAAGATCAAC
AGCCTTAGAAGGGACCAGGAAAAGAATCTTTTAAAATAGATTTCTAAGAGATGCCTACAAAACACAGAATGTGACCGTGGCAGAGACCAA
CACTTAGATGTAGAAATGCTGCCCCCTAGGGTCATCCTCTGCATAAGTTCTAGGAAAGCATCACCATCCTTGCAGAGGGAAGTCCTCGAA
GCACGCAGCACAGGCATATGAAGGGCGAGTGTGGGATCCTAGGCCCAAGCTCTTCAACTCTAAAACCAATCACACACAAGATCCTGTTTT
CATCTCAGGGAGAGATTTCTAAGTCATCTGGGGCTTGAGGGCTTATTTAAGGGTGGTCAATGGACATATTCCTGGACCCACACAAAAGTA
GAGCAGCTGCTGATACCCTAATTGGACAGCCCCAAACGCAGAACAGAACAAGTCACTTGTAGACTTGACCTCCCCTATTTTGTCCCCCGA
GATGGTAGAACCATGTCCATGTTTACAATATGACAACTGTGGAATAATTGGGGTTCTTAGGGAGAGATTTGCATAATTTTAAAGACATCC
TTTCATCTGGACCAGAGGTCAATCAACTTATGTCAAGTGCTACACAGTAAATATTTTGGTTTAGCACGCCATACTGTGTCACAACTGCTC
AATTCTGCCATCACAGCACAAAAACAGCCACAGATAATTTGTAAATGAAGGAACATGGCTGTGTTCCAATAAAACTTTATGAAAACAGTG
AGCTGAATTTAGCCTACAGGCCATAATACGCCAATCCTGCTCTAGACAATAAAACTGATCCTTACCAGTATGTTAGCAGAAGAGGGTCAG
TCAGCTCTGTTTCCATGCCTGACATGTATCAAAGATCTGGGACCTCTTCCCAGTGGAGGCACTAGGGTTGCTTGTTTAAAGGGTGCTTGA
ACAACTAACCAGCAAAGAGATGTCTGATGCCAAATGGGCAAGATCAAATACTGGAATGCTAAAACACAGCTGGAATCTAAGAAGGGAAGA
GGGCTTCTCTGACCATTTTCATACCAGCAACAATTTAGGCAGAATTATAAACATCTATTTATCGAGTGACAATACAAACCGAAGGAGATC
CTAGTAGAGATTAGGGGTCAGTTAAAATCAACTAGCCACTGCCACTTGTCATCTACATAGCAAAGGCTTTATTTAGCACAGGACTAACGT
GAAAAGTAGACCCAGAGATGAAAAGGCTGTCAGGAGACAGGGGGCTGGTGTCCACCTGGTATCTACTGTCTTATGCAACATAGAAGATTA
CCTTTTAGTGTAGTGCTCCTACCTCAGTTTGTAGAATCTGGTGTTTCTATGCAGTGAGTGATAGCCTCAACTCTGACCTTTCATATTCAC
ATTAGAGACAGATGCAGTATTCCATATCCTAGTATGTTCCTTGTGTCTAGAGTTCTAACAGTACAGTAGTCTATGCCATTTCTAACAGCT
AAATTTTGCTCTGTAAACAGAAACTTTAGGGTTGTTTTTTTCCAGGGCTCATCCCAGAAAATATGGATAGAAAAGTTTCCTTCAGTTTGC
TTTTCAAATAGTGCTTGAATAATAAACCTCCTTTGATTGGTGACTAGTCTTTTTTGGTATATCTCCACCTTTAAAAATTGTTCAAGTTTT
TAACCTGGTTATACTGTGTTCTAACATGTCTCTCATTTTCTCTCAAAATTAGTTTATCTCATTGTAGAAAAAGCAATGGTTTTCATAGCT
TCATCTATCAGGAAATAAAACTCTTACTAAAGAATAGCATACTGCATCTTTAAGCAGTAGAGGGTAAACTACCTGCAAATGTGAATTTCT
TAGATACATTTAAAAATATATAGTTGTTAACCTTCTGTGTGCCAAAAACTCTTAAGTTACATTTTCCTTCAAAGCAATGTACTTTTTTCT

>52496_52496_4_MECOM-FRMD5_MECOM_chr3_168810746_ENST00000464456_FRMD5_chr15_44180464_ENST00000402883_length(amino acids)=951AA_BP=860
MLFMKSEDYPHETMAPDIHEERQYRCEDCDQLFESKAELADHQKFPCSTPHSAFSMVEEDFQQKLESENDLQEIHTIQECKECDQVFPDL
QSLEKHMLSHTEEREYKCDQCPKAFNWKSNLIRHQMSHDSGKHYECENCAKVFTDPSNLQRHIRSQHVGARAHACPECGKTFATSSGLKQ
HKHIHSSVKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFCEGKNHFAAGGFFGQGISLPGTPAMDKTS
MVNMSHANPGLADYFGANRHPAGLTFPTAPGFSFSFPGLFPSGLYHRPPLIPASSPVKGLSSTEQTNKSQSPLMTHPQILPATQDILKAL
SKHPSVGDNKPVELQPERSSEERPFEKISDQSESSDLDDVSTPSGSDLETTSGSDLESDIESDKEKFKENGKMFKDKVSPLQNLASINNK
KEYSNHSIFSPSLEEQTAVSGAVNDSIKAIASIAEKYFGSTGLVGLQDKKVGALPYPSMFPLPFFPAFSQSMYPFPDRDLRSLPLKMEPQ
SPGEVKKLQKGSSESPFDLTTKRKDEKPLTPVPSKPPVTPATSQDQPLDLSMGSRSRASGTKLTEPRKNHVFGGKKGSNVESRPASDGSL
QHARPTPFFMDPIYRVEKRKLTDPLEALKEKYLRPSPGFLFHPQMSAIENMAEKLESFSALKPEASELLQSVPSMFNFRAPPNALPENLL
RKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRHVRNIHNKEKPFKCHLCDRCFGQQTNLDRHLKKHENGN
MSGTATSSPHSELESTGAILDDKEDAYFTEIRNFIGNSNHGSQSPRNVEERKRKLFLHILLQLLKRVSTSGNVESRTKPSTSWRSQAKSA

--------------------------------------------------------------
>52496_52496_5_MECOM-FRMD5_MECOM_chr3_168810746_ENST00000464456_FRMD5_chr15_44180464_ENST00000417257_length(transcript)=7816nt_BP=3774nt
CACACACACACACACACACCACACTTGTGCTTTCAAGACATCGAAACGGAGGCTATTTCCCTGGGGAAAGAAATCCTGCCTGGCGAGATC
TCCCCATTGGTTGTTTACCCGGAGAAATCTACATGTTTAAGGGGGATGGTGCATCCATAATCAGTCTGTCCCTATAGGACTTGGGTCTTG
GCGACCTTTTTGTGACCTCTCCCGCCAGAGGAGGCTGCTGTCACTTTAAAAATTTAAAAGAGGAGCCCGTCTGGCTTCCGATCAGATCAC
TCTGGGCGGCGGGAGATAGCTCCCTTTCTCCCTCGCCCCGGGTTCTTTCTGGATGGCCGAGCAGATCCTCTTTAAAGAGACAGTTCATGA
AATAGAAACCCGGCGGCTGAGCTTGGAGTTGCGAAAGGGGACGATCCCGTGAGGGTCCAGGACCCGCGAAGGCGCTGCGGAGGATCTGAA
AGGGGGATAGAGCTCCCCTCGCCTCCCCAGGCCCCCCACCTTTTCAAACTCTCCTCCTCCTGCTTGTTTTCCCCCATTGGAACTGGGAAG
GAGAAGTAGAAGTTTTAGTGGGTTTCAGATAACTTTCATTACACATCGGGCTGATAAGAGCAAGAGAAAGTGAGAAAAGAGGGAGGTGAT
GTGAACCAGAAGGAATAGCTCCGAGCTCATTTAGGAAGGGGGAAAAAGCCAAAACACACCAAACCCGGGTCACCCAGACGAAAGAAGACT
TCATTTCTTGTATTAAAAATACACTGTTGGCGGACAATAAATCCGAAACGCGTGGTCCTGGAGAGCAGATCCTAGAGACGGACAAAGTTG
TCAGAGACCCATTTGGAAATCGAGACGCGAGGCTTTTAAAAAATTATTATTATTATTTTTAAACATCTCTAAATGTTGCTCGGGATCGTT
TGAAAGGATTTTCGTGCAGGAGCGTTGGGGGCTGCTGATTATTTTATTTTGTTTATTTTGATTCTTCTGTGAATGCCTATTATTGCTGAG
TTGAGGCCATAGAAATCTAAAGATCTTAGACGAATTTTACAATGTGAAGTTCTGCATAGATGCCAGTCAACCAGATGTTGGAAGCTGGCT
CAAGTACATTAGATTCGCTGGCTGTTATGATCAGCACAACCTTGTTGCATGCCAGATAAATGATCAGATATTCTATAGAGTAGTTGCAGA
CATTGCGCCGGGAGAGGAGCTTCTGCTGTTCATGAAGAGCGAAGACTATCCCCATGAAACTATGGCGCCGGATATCCACGAAGAACGGCA
ATATCGCTGCGAAGACTGTGACCAGCTCTTTGAATCTAAGGCTGAACTAGCAGATCACCAAAAGTTTCCATGCAGTACTCCTCACTCAGC
ATTTTCAATGGTTGAAGAGGACTTTCAGCAAAAACTCGAAAGCGAGAATGATCTCCAAGAGATACACACGATCCAGGAGTGTAAGGAATG
TGACCAAGTTTTTCCTGATTTGCAAAGCCTGGAGAAACACATGCTGTCACATACTGAAGAGAGGGAATACAAGTGTGATCAGTGTCCCAA
GGCATTTAACTGGAAGTCCAATTTAATTCGCCACCAGATGTCACATGACAGTGGAAAGCACTATGAATGTGAAAACTGTGCCAAGGTTTT
CACGGACCCTAGCAACCTTCAGCGGCACATTCGCTCTCAGCATGTCGGTGCCCGGGCCCATGCATGCCCGGAGTGTGGCAAAACGTTTGC
CACTTCGTCGGGCCTCAAACAACACAAGCACATCCACAGCAGTGTGAAGCCCTTTATCTGTGAGGTCTGCCATAAATCCTATACTCAGTT
TTCAAACCTTTGCCGTCATAAGCGCATGCATGCTGATTGCAGAACCCAAATCAAGTGCAAAGACTGTGGACAAATGTTCAGCACTACGTC
TTCCTTAAATAAACACAGGAGGTTTTGTGAGGGCAAGAACCATTTTGCGGCAGGTGGATTTTTTGGCCAAGGCATTTCACTTCCTGGAAC
CCCAGCTATGGATAAAACGTCCATGGTTAATATGAGTCATGCCAACCCGGGCCTTGCTGACTATTTTGGCGCCAATAGGCATCCTGCTGG
TCTTACCTTTCCAACAGCTCCTGGATTTTCTTTTAGCTTCCCTGGTCTGTTTCCTTCCGGCTTGTACCACAGGCCTCCTTTGATACCTGC
TAGTTCTCCTGTTAAAGGACTATCAAGTACTGAACAGACAAACAAAAGTCAAAGTCCCCTCATGACACATCCTCAGATACTGCCAGCTAC
ACAGGATATTTTGAAGGCACTATCTAAACACCCATCTGTAGGGGACAATAAGCCAGTGGAGCTCCAGCCCGAGAGGTCCTCTGAAGAGAG
GCCCTTTGAGAAAATCAGTGACCAGTCAGAGAGTAGTGACCTTGATGATGTCAGTACACCAAGTGGCAGTGACCTGGAAACAACCTCGGG
CTCTGATCTGGAAAGTGACATTGAAAGTGATAAAGAGAAATTTAAAGAAAATGGTAAAATGTTCAAAGACAAAGTAAGCCCTCTTCAGAA
TCTGGCTTCAATAAATAATAAGAAAGAATACAGCAATCATTCCATTTTCTCACCATCTTTAGAGGAGCAGACTGCGGTGTCAGGAGCTGT
GAATGATTCTATAAAGGCTATTGCTTCTATTGCTGAAAAATACTTTGGTTCAACAGGACTGGTGGGGCTGCAAGACAAAAAAGTTGGAGC
TTTACCTTACCCTTCCATGTTTCCCCTCCCATTTTTTCCAGCATTCTCTCAATCAATGTACCCATTTCCTGATAGAGACTTGAGATCGTT
ACCTTTGAAAATGGAACCCCAATCACCAGGTGAAGTAAAGAAACTGCAGAAGGGCAGCTCTGAGTCCCCCTTTGATCTCACCACTAAGCG
AAAGGATGAGAAGCCCTTGACTCCAGTCCCCTCCAAGCCTCCAGTGACACCTGCCACAAGCCAAGACCAGCCCCTGGATCTAAGTATGGG
CAGTAGGAGTAGAGCCAGTGGGACAAAGCTGACTGAGCCTCGAAAAAACCACGTGTTTGGGGGAAAAAAAGGAAGCAACGTCGAATCAAG
ACCTGCTTCAGATGGTTCCTTGCAGCATGCAAGACCCACTCCTTTCTTTATGGACCCTATTTACAGAGTAGAGAAAAGAAAACTAACTGA
CCCACTTGAAGCTTTAAAAGAGAAATACTTGAGGCCTTCTCCAGGATTCTTGTTTCACCCACAAATGTCAGCTATTGAAAACATGGCAGA
AAAGCTAGAGAGCTTCAGTGCCCTGAAACCTGAGGCCAGTGAGCTCTTACAGTCAGTGCCCTCTATGTTCAACTTCAGGGCGCCTCCCAA
TGCCCTGCCAGAGAACCTTCTGCGGAAGGGAAAGGAGCGCTATACCTGCAGATACTGTGGCAAGATTTTTCCAAGGTCTGCAAACCTAAC
ACGGCACTTGAGAACCCACACAGGAGAGCAGCCTTACAGATGCAAATACTGTGACAGATCATTTAGCATATCTTCTAACTTGCAAAGGCA
TGTTCGCAACATCCACAATAAAGAGAAGCCATTTAAGTGTCACTTATGTGATAGGTGTTTTGGTCAACAAACCAATTTAGACAGACACCT
AAAGAAACATGAGAATGGGAACATGTCCGGTACAGCAACATCGTCGCCTCATTCTGAACTGGAAAGTACAGGTGCGATTCTGGATGACAA
AGAAGATGCTTACTTCACAGAAATTCGAAATTTCATTGGGAACAGCAACCATGGCAGCCAATCTCCCAGGAATGTGGAGGAGAGGAAAAG
AAAATTATTCTTACATATTTTGCTCCAACTCCTGAAGCGTGTAAGCACCTCTGGAAATGTGGAATCGAGAACCAAGCCTTCTACAAGCTG
GAGAAGTCAAGCCAAGTCCGCACAGTGTCCAGCAGCAATTTATTCTTTAAAGGGAGCCGGTTCCGATACAGTGGCCGAGTTGCAAAGGAA
GTCATGGAATCAAGTGCTAAGATCAAACGGGAGCCACCGGAAATACACAGAGCAGGGATGGTTCCCAGCCGGAGCTGTCCCTCCATAACC
CATGGCCCAAGGCTGAGCAGCGTCCCCAGGACCCGCAGAAGAGCTGTTCACATCTCCATCATGGAAGGCCTAGAGTCCTTACGGGACAGT
GCCCATTCCACACCAGTGCGTTCCACTTCCCATGGGGACACCTTCCTGCCTCACGTGAGAAGCAGCCGGACAGATAGCAATGAGCGAGTA
GCTGTGATTGCAGACGAGGCCTACAGCCCTGCAGACAGCGTGCTGCCCACCCCTGTGGCTGAGCACAGCCTGGAGCTGATGTTGCTTTCC
CGGCAGATCAATGGAGCCACCTGCAGCATTGAGGAGGAGAAGGAATCTGAAGCCAGCACCCCAACTGCTACAGAGGTGGAGGCCCTTGGG
GGAGAGCTGAGGGCCCTGTGTCAGGGGCACAGCGGGCCCGAGGAGGAACAGGTGAATAAGTTTGTTCTAAGTGTCCTCCGTTTGCTCCTT
GTGACCATGGGACTCCTCTTTGTTTTGCTCCTCCTCCTGATCATCCTTACCGAGTCTGACCTTGACATTGCCTTTTTCCGTGATATCCGC
CAGACCCCCGAGTTTGAACAATTCCACTATCAATACTTTTGTCCCCTCAGGCGATGGTTTGCCTGCAAAATCCGCTCAGTGGTGAGCCTG
CTCATTGACACCTGAGAAGGCATGACTCCTCCCAAAAACTAGCCAGGTGGACCAAGGAACCCGGCTACCCATTCCCAGCAATGGGACCCA
TCGCGGAACCATCGGCACATATACCAAGTCCTCCTCTCATGACTCAAAGTCCACTGCAGCCTAGGAGGGTGTTTCCCAGAAGAAGAAAGG
GATAGGCTCATGCCCTGTCTAAACAAACTGGGAAAACTCATTTTCTTCAGAAGTTATTTCAAGAAAGGCTCAGCGACTCTGTTTCTCATC
TTTCCAATTTGCAGGATAATTTTTGGTTTTGAATTTTGATTTTTCATAGATGTATATTATTTTGAAGTATCAAATAAAAATAATTTATTT
TACTATTACTGATTATTGCAGTAGTATCACCTAGCAGAGGGGACACTAGTTGAAAACTAGAGAGCTGCTGTCCTCTGTATTCTGCAGGAG
CTTTTCCTGCTGGTGCCACTGGGTTCCAGTAGACTCATCACTGCAGCCTCAGCAGGGCAGGCCAGGGATCTGGACAATGGGGACTGTTTA
GTTTTTTGTTTGTTTTTTTTGCCAGCCAGAACTTTTAAAAAAGTAAACATCCATGTAGAATGATTAAATGGAAAGTTGCTTCTTATGATG
GTCTGAGTTGGATTTTCTTTTCCTTTTGTTTTTTCAAATCTGAGCAGAGTGGGCATCTGAAGGGACCACCGCTACAGCAACAGCAGCATC
AGGGGTGGGGTAAGTCTGTCCCCTTAGTCTAGAGCCTAGTGGGCATCACCATAGTTTTGTATAATGAAACTAGACTTAACGTGATTTTTT
TTTTCCGAAGAACCTCAAGACTTTTATAGTGCTCCAGGGGCGTTAAACGAATTCAGTGGTACCAGAGATAGATAGTTCTGTCAGAAATGT
TGGACAAAGTGTAGTTAAGAGAAAGCAGAGTTAAGTTACCTGAGAGACTGTTGAGATTTGGATAGCAGTGCTTATTTTATATACACCCCC
TTGACCCAAAGACTATTTCAATTTATATTTTAACAACGAAATGTTATTTTCTTAACAATTCATATTTTGTTTTTACTTTATGGATTAAGA
AAATAGAGCCTGATGAACTAAACGATGCAAGAAAGAAACTGATCCTGAGAATGAAAAGCTTCAGAAAATAGAATTCCAAGATCAACAGCC
TTAGAAGGGACCAGGAAAAGAATCTTTTAAAATAGATTTCTAAGAGATGCCTACAAAACACAGAATGTGACCGTGGCAGAGACCAACACT
TAGATGTAGAAATGCTGCCCCCTAGGGTCATCCTCTGCATAAGTTCTAGGAAAGCATCACCATCCTTGCAGAGGGAAGTCCTCGAAGCAC
GCAGCACAGGCATATGAAGGGCGAGTGTGGGATCCTAGGCCCAAGCTCTTCAACTCTAAAACCAATCACACACAAGATCCTGTTTTCATC
TCAGGGAGAGATTTCTAAGTCATCTGGGGCTTGAGGGCTTATTTAAGGGTGGTCAATGGACATATTCCTGGACCCACACAAAAGTAGAGC
AGCTGCTGATACCCTAATTGGACAGCCCCAAACGCAGAACAGAACAAGTCACTTGTAGACTTGACCTCCCCTATTTTGTCCCCCGAGATG
GTAGAACCATGTCCATGTTTACAATATGACAACTGTGGAATAATTGGGGTTCTTAGGGAGAGATTTGCATAATTTTAAAGACATCCTTTC
ATCTGGACCAGAGGTCAATCAACTTATGTCAAGTGCTACACAGTAAATATTTTGGTTTAGCACGCCATACTGTGTCACAACTGCTCAATT
CTGCCATCACAGCACAAAAACAGCCACAGATAATTTGTAAATGAAGGAACATGGCTGTGTTCCAATAAAACTTTATGAAAACAGTGAGCT
GAATTTAGCCTACAGGCCATAATACGCCAATCCTGCTCTAGACAATAAAACTGATCCTTACCAGTATGTTAGCAGAAGAGGGTCAGTCAG
CTCTGTTTCCATGCCTGACATGTATCAAAGATCTGGGACCTCTTCCCAGTGGAGGCACTAGGGTTGCTTGTTTAAAGGGTGCTTGAACAA
CTAACCAGCAAAGAGATGTCTGATGCCAAATGGGCAAGATCAAATACTGGAATGCTAAAACACAGCTGGAATCTAAGAAGGGAAGAGGGC
TTCTCTGACCATTTTCATACCAGCAACAATTTAGGCAGAATTATAAACATCTATTTATCGAGTGACAATACAAACCGAAGGAGATCCTAG
TAGAGATTAGGGGTCAGTTAAAATCAACTAGCCACTGCCACTTGTCATCTACATAGCAAAGGCTTTATTTAGCACAGGACTAACGTGAAA
AGTAGACCCAGAGATGAAAAGGCTGTCAGGAGACAGGGGGCTGGTGTCCACCTGGTATCTACTGTCTTATGCAACATAGAAGATTACCTT
TTAGTGTAGTGCTCCTACCTCAGTTTGTAGAATCTGGTGTTTCTATGCAGTGAGTGATAGCCTCAACTCTGACCTTTCATATTCACATTA
GAGACAGATGCAGTATTCCATATCCTAGTATGTTCCTTGTGTCTAGAGTTCTAACAGTACAGTAGTCTATGCCATTTCTAACAGCTAAAT
TTTGCTCTGTAAACAGAAACTTTAGGGTTGTTTTTTTCCAGGGCTCATCCCAGAAAATATGGATAGAAAAGTTTCCTTCAGTTTGCTTTT
CAAATAGTGCTTGAATAATAAACCTCCTTTGATTGGTGACTAGTCTTTTTTGGTATATCTCCACCTTTAAAAATTGTTCAAGTTTTTAAC
CTGGTTATACTGTGTTCTAACATGTCTCTCATTTTCTCTCAAAATTAGTTTATCTCATTGTAGAAAAAGCAATGGTTTTCATAGCTTCAT
CTATCAGGAAATAAAACTCTTACTAAAGAATAGCATACTGCATCTTTAAGCAGTAGAGGGTAAACTACCTGCAAATGTGAATTTCTTAGA
TACATTTAAAAATATATAGTTGTTAACCTTCTGTGTGCCAAAAACTCTTAAGTTACATTTTCCTTCAAAGCAATGTACTTTTTTCTACAT

>52496_52496_5_MECOM-FRMD5_MECOM_chr3_168810746_ENST00000464456_FRMD5_chr15_44180464_ENST00000417257_length(amino acids)=951AA_BP=860
MLFMKSEDYPHETMAPDIHEERQYRCEDCDQLFESKAELADHQKFPCSTPHSAFSMVEEDFQQKLESENDLQEIHTIQECKECDQVFPDL
QSLEKHMLSHTEEREYKCDQCPKAFNWKSNLIRHQMSHDSGKHYECENCAKVFTDPSNLQRHIRSQHVGARAHACPECGKTFATSSGLKQ
HKHIHSSVKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFCEGKNHFAAGGFFGQGISLPGTPAMDKTS
MVNMSHANPGLADYFGANRHPAGLTFPTAPGFSFSFPGLFPSGLYHRPPLIPASSPVKGLSSTEQTNKSQSPLMTHPQILPATQDILKAL
SKHPSVGDNKPVELQPERSSEERPFEKISDQSESSDLDDVSTPSGSDLETTSGSDLESDIESDKEKFKENGKMFKDKVSPLQNLASINNK
KEYSNHSIFSPSLEEQTAVSGAVNDSIKAIASIAEKYFGSTGLVGLQDKKVGALPYPSMFPLPFFPAFSQSMYPFPDRDLRSLPLKMEPQ
SPGEVKKLQKGSSESPFDLTTKRKDEKPLTPVPSKPPVTPATSQDQPLDLSMGSRSRASGTKLTEPRKNHVFGGKKGSNVESRPASDGSL
QHARPTPFFMDPIYRVEKRKLTDPLEALKEKYLRPSPGFLFHPQMSAIENMAEKLESFSALKPEASELLQSVPSMFNFRAPPNALPENLL
RKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRHVRNIHNKEKPFKCHLCDRCFGQQTNLDRHLKKHENGN
MSGTATSSPHSELESTGAILDDKEDAYFTEIRNFIGNSNHGSQSPRNVEERKRKLFLHILLQLLKRVSTSGNVESRTKPSTSWRSQAKSA

--------------------------------------------------------------
>52496_52496_6_MECOM-FRMD5_MECOM_chr3_168810746_ENST00000464456_FRMD5_chr15_44180464_ENST00000484674_length(transcript)=5126nt_BP=3774nt
CACACACACACACACACACCACACTTGTGCTTTCAAGACATCGAAACGGAGGCTATTTCCCTGGGGAAAGAAATCCTGCCTGGCGAGATC
TCCCCATTGGTTGTTTACCCGGAGAAATCTACATGTTTAAGGGGGATGGTGCATCCATAATCAGTCTGTCCCTATAGGACTTGGGTCTTG
GCGACCTTTTTGTGACCTCTCCCGCCAGAGGAGGCTGCTGTCACTTTAAAAATTTAAAAGAGGAGCCCGTCTGGCTTCCGATCAGATCAC
TCTGGGCGGCGGGAGATAGCTCCCTTTCTCCCTCGCCCCGGGTTCTTTCTGGATGGCCGAGCAGATCCTCTTTAAAGAGACAGTTCATGA
AATAGAAACCCGGCGGCTGAGCTTGGAGTTGCGAAAGGGGACGATCCCGTGAGGGTCCAGGACCCGCGAAGGCGCTGCGGAGGATCTGAA
AGGGGGATAGAGCTCCCCTCGCCTCCCCAGGCCCCCCACCTTTTCAAACTCTCCTCCTCCTGCTTGTTTTCCCCCATTGGAACTGGGAAG
GAGAAGTAGAAGTTTTAGTGGGTTTCAGATAACTTTCATTACACATCGGGCTGATAAGAGCAAGAGAAAGTGAGAAAAGAGGGAGGTGAT
GTGAACCAGAAGGAATAGCTCCGAGCTCATTTAGGAAGGGGGAAAAAGCCAAAACACACCAAACCCGGGTCACCCAGACGAAAGAAGACT
TCATTTCTTGTATTAAAAATACACTGTTGGCGGACAATAAATCCGAAACGCGTGGTCCTGGAGAGCAGATCCTAGAGACGGACAAAGTTG
TCAGAGACCCATTTGGAAATCGAGACGCGAGGCTTTTAAAAAATTATTATTATTATTTTTAAACATCTCTAAATGTTGCTCGGGATCGTT
TGAAAGGATTTTCGTGCAGGAGCGTTGGGGGCTGCTGATTATTTTATTTTGTTTATTTTGATTCTTCTGTGAATGCCTATTATTGCTGAG
TTGAGGCCATAGAAATCTAAAGATCTTAGACGAATTTTACAATGTGAAGTTCTGCATAGATGCCAGTCAACCAGATGTTGGAAGCTGGCT
CAAGTACATTAGATTCGCTGGCTGTTATGATCAGCACAACCTTGTTGCATGCCAGATAAATGATCAGATATTCTATAGAGTAGTTGCAGA
CATTGCGCCGGGAGAGGAGCTTCTGCTGTTCATGAAGAGCGAAGACTATCCCCATGAAACTATGGCGCCGGATATCCACGAAGAACGGCA
ATATCGCTGCGAAGACTGTGACCAGCTCTTTGAATCTAAGGCTGAACTAGCAGATCACCAAAAGTTTCCATGCAGTACTCCTCACTCAGC
ATTTTCAATGGTTGAAGAGGACTTTCAGCAAAAACTCGAAAGCGAGAATGATCTCCAAGAGATACACACGATCCAGGAGTGTAAGGAATG
TGACCAAGTTTTTCCTGATTTGCAAAGCCTGGAGAAACACATGCTGTCACATACTGAAGAGAGGGAATACAAGTGTGATCAGTGTCCCAA
GGCATTTAACTGGAAGTCCAATTTAATTCGCCACCAGATGTCACATGACAGTGGAAAGCACTATGAATGTGAAAACTGTGCCAAGGTTTT
CACGGACCCTAGCAACCTTCAGCGGCACATTCGCTCTCAGCATGTCGGTGCCCGGGCCCATGCATGCCCGGAGTGTGGCAAAACGTTTGC
CACTTCGTCGGGCCTCAAACAACACAAGCACATCCACAGCAGTGTGAAGCCCTTTATCTGTGAGGTCTGCCATAAATCCTATACTCAGTT
TTCAAACCTTTGCCGTCATAAGCGCATGCATGCTGATTGCAGAACCCAAATCAAGTGCAAAGACTGTGGACAAATGTTCAGCACTACGTC
TTCCTTAAATAAACACAGGAGGTTTTGTGAGGGCAAGAACCATTTTGCGGCAGGTGGATTTTTTGGCCAAGGCATTTCACTTCCTGGAAC
CCCAGCTATGGATAAAACGTCCATGGTTAATATGAGTCATGCCAACCCGGGCCTTGCTGACTATTTTGGCGCCAATAGGCATCCTGCTGG
TCTTACCTTTCCAACAGCTCCTGGATTTTCTTTTAGCTTCCCTGGTCTGTTTCCTTCCGGCTTGTACCACAGGCCTCCTTTGATACCTGC
TAGTTCTCCTGTTAAAGGACTATCAAGTACTGAACAGACAAACAAAAGTCAAAGTCCCCTCATGACACATCCTCAGATACTGCCAGCTAC
ACAGGATATTTTGAAGGCACTATCTAAACACCCATCTGTAGGGGACAATAAGCCAGTGGAGCTCCAGCCCGAGAGGTCCTCTGAAGAGAG
GCCCTTTGAGAAAATCAGTGACCAGTCAGAGAGTAGTGACCTTGATGATGTCAGTACACCAAGTGGCAGTGACCTGGAAACAACCTCGGG
CTCTGATCTGGAAAGTGACATTGAAAGTGATAAAGAGAAATTTAAAGAAAATGGTAAAATGTTCAAAGACAAAGTAAGCCCTCTTCAGAA
TCTGGCTTCAATAAATAATAAGAAAGAATACAGCAATCATTCCATTTTCTCACCATCTTTAGAGGAGCAGACTGCGGTGTCAGGAGCTGT
GAATGATTCTATAAAGGCTATTGCTTCTATTGCTGAAAAATACTTTGGTTCAACAGGACTGGTGGGGCTGCAAGACAAAAAAGTTGGAGC
TTTACCTTACCCTTCCATGTTTCCCCTCCCATTTTTTCCAGCATTCTCTCAATCAATGTACCCATTTCCTGATAGAGACTTGAGATCGTT
ACCTTTGAAAATGGAACCCCAATCACCAGGTGAAGTAAAGAAACTGCAGAAGGGCAGCTCTGAGTCCCCCTTTGATCTCACCACTAAGCG
AAAGGATGAGAAGCCCTTGACTCCAGTCCCCTCCAAGCCTCCAGTGACACCTGCCACAAGCCAAGACCAGCCCCTGGATCTAAGTATGGG
CAGTAGGAGTAGAGCCAGTGGGACAAAGCTGACTGAGCCTCGAAAAAACCACGTGTTTGGGGGAAAAAAAGGAAGCAACGTCGAATCAAG
ACCTGCTTCAGATGGTTCCTTGCAGCATGCAAGACCCACTCCTTTCTTTATGGACCCTATTTACAGAGTAGAGAAAAGAAAACTAACTGA
CCCACTTGAAGCTTTAAAAGAGAAATACTTGAGGCCTTCTCCAGGATTCTTGTTTCACCCACAAATGTCAGCTATTGAAAACATGGCAGA
AAAGCTAGAGAGCTTCAGTGCCCTGAAACCTGAGGCCAGTGAGCTCTTACAGTCAGTGCCCTCTATGTTCAACTTCAGGGCGCCTCCCAA
TGCCCTGCCAGAGAACCTTCTGCGGAAGGGAAAGGAGCGCTATACCTGCAGATACTGTGGCAAGATTTTTCCAAGGTCTGCAAACCTAAC
ACGGCACTTGAGAACCCACACAGGAGAGCAGCCTTACAGATGCAAATACTGTGACAGATCATTTAGCATATCTTCTAACTTGCAAAGGCA
TGTTCGCAACATCCACAATAAAGAGAAGCCATTTAAGTGTCACTTATGTGATAGGTGTTTTGGTCAACAAACCAATTTAGACAGACACCT
AAAGAAACATGAGAATGGGAACATGTCCGGTACAGCAACATCGTCGCCTCATTCTGAACTGGAAAGTACAGGTGCGATTCTGGATGACAA
AGAAGATGCTTACTTCACAGAAATTCGAAATTTCATTGGGAACAGCAACCATGGCAGCCAATCTCCCAGGAATGTGGAGGAGAGGAAAAG
AAAATTATTCTTACATATTTTGCTCCAACTCCTGAAGCGTGTAAGCACCTCTGGAAATGTGGAATCGAGAACCAAGCCTTCTACAAGCTG
GAGAAGTCAAGCCAAGTCCGCACAGTGTCCAGCAGCAATTTATTCTTTAAAGGGAGCCGGTTCCGATACAGTGGCCGAGTTGCAAAGGAA
GTCATGGAATCAAGTGCTAAGATCAAACGGGAGCCACCGGAAATACACAGAGCAGGGATGGTTCCCAGCCGGAGCTGTCCCTCCATAACC
CATGGCCCAAGGCTGAGCAGCGTCCCCAGGACCCGCAGAAGAGCTGTTCACATCTCCATCATGGAAGGCCTAGAGTCCTTACGGGACAGT
GCCCATTCCACACCAGTGCGTTCCACTTCCCATGGGGACACCTTCCTGCCTCACGTGAGAAGCAGCCGGACAGATAGCAATGAGCGAGTA
GCTGTGATTGCAGACGAGGCCTACAGCCCTGCAGACAGCGTGCTGCCCACCCCTGTGGCTGAGCACAGCCTGGAGCTGATGTTGCTTTCC
CGGCAGATCAATGGAGCCACCTGCAGCATTGAGGAGGAGAAGGAATCTGAAGCCAGCACCCCAACTGCTACAGAGGTGGAGGCCCTTGGG
GGAGAGCTGAGGGCCCTGTGTCAGGGGCACAGCGGGCCCGAGGAGGAACAGGCGATGGTTTGCCTGCAAAATCCGCTCAGTGGTGAGCCT
GCTCATTGACACCTGAGAAGGCATGACTCCTCCCAAAAACTAGCCAGGTGGACCAAGGAACCCGGCTACCCATTCCCAGCAATGGGACCC
ATCGCGGAACCATCGGCACATATACCAAGTCCTCCTCTCATGACTCAAAGTCCACTGCAGCCTAGGAGGGTGTTTCCCAGAAGAAGAAAG
GGATAGGCTCATGCCCTGTCTAAACAAACTGGGAAAACTCATTTTCTTCAGAAGTTATTTCAAGAAAGGCTCAGCGACTCTGTTTCTCAT
CTTTCCAATTTGCAGGATAATTTTTGGTTTTGAATTTTGATTTTTCATAGATGTATATTATTTTGAAGTATCAAATAAAAATAATTTATT
TTACTATTACTGATTATTGCAGTAGTATCACCTAGCAGAGGGGACACTAGTTGAAAACTAGAGAGCTGCTGTCCTCTGTATTCTGCAGGA
GCTTTTCCTGCTGGTGCCACTGGGTTCCAGTAGACTCATCACTGCAGCCTCAGCAGGGCAGGCCAGGGATCTGGACAATGGGGACTGTTT

>52496_52496_6_MECOM-FRMD5_MECOM_chr3_168810746_ENST00000464456_FRMD5_chr15_44180464_ENST00000484674_length(amino acids)=951AA_BP=860
MLFMKSEDYPHETMAPDIHEERQYRCEDCDQLFESKAELADHQKFPCSTPHSAFSMVEEDFQQKLESENDLQEIHTIQECKECDQVFPDL
QSLEKHMLSHTEEREYKCDQCPKAFNWKSNLIRHQMSHDSGKHYECENCAKVFTDPSNLQRHIRSQHVGARAHACPECGKTFATSSGLKQ
HKHIHSSVKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFCEGKNHFAAGGFFGQGISLPGTPAMDKTS
MVNMSHANPGLADYFGANRHPAGLTFPTAPGFSFSFPGLFPSGLYHRPPLIPASSPVKGLSSTEQTNKSQSPLMTHPQILPATQDILKAL
SKHPSVGDNKPVELQPERSSEERPFEKISDQSESSDLDDVSTPSGSDLETTSGSDLESDIESDKEKFKENGKMFKDKVSPLQNLASINNK
KEYSNHSIFSPSLEEQTAVSGAVNDSIKAIASIAEKYFGSTGLVGLQDKKVGALPYPSMFPLPFFPAFSQSMYPFPDRDLRSLPLKMEPQ
SPGEVKKLQKGSSESPFDLTTKRKDEKPLTPVPSKPPVTPATSQDQPLDLSMGSRSRASGTKLTEPRKNHVFGGKKGSNVESRPASDGSL
QHARPTPFFMDPIYRVEKRKLTDPLEALKEKYLRPSPGFLFHPQMSAIENMAEKLESFSALKPEASELLQSVPSMFNFRAPPNALPENLL
RKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRHVRNIHNKEKPFKCHLCDRCFGQQTNLDRHLKKHENGN
MSGTATSSPHSELESTGAILDDKEDAYFTEIRNFIGNSNHGSQSPRNVEERKRKLFLHILLQLLKRVSTSGNVESRTKPSTSWRSQAKSA

--------------------------------------------------------------
>52496_52496_7_MECOM-FRMD5_MECOM_chr3_168810746_ENST00000468789_FRMD5_chr15_44180464_ENST00000402883_length(transcript)=6131nt_BP=2988nt
AAAGTTTGTCACTTCGGACAGTTTCCTGCCGGGGCACCGTTTCTACGGGCGCCCCCCGCCCCCAGCCTTCTTTCCTCCTCGCCCGCAGTC
TCGCGGAGCCCTGCTGCTTATCTACGTTGCTAAGCCGGGCGATTTCCTTGTTCCTCCTGCGAAACGGTGCGGTCTGGACACGTCTCCGGG
GTGGGTCGTCCGGCCTTCGATCTTAGACGAATTTTACAATGTGAAGTTCTGCATAGATGCCAGTCAACCAGATGTTGGAAGCTGGCTCAA
GTACATTAGATTCGCTGGCTGTTATGATCAGCACAACCTTGTTGCATGCCAGATAAATGATCAGATATTCTATAGAGTAGTTGCAGACAT
TGCGCCGGGAGAGGAGCTTCTGCTGTTCATGAAGAGCGAAGACTATCCCCATGAAACTATGGCGCCGGATATCCACGAAGAACGGCAATA
TCGCTGCGAAGACTGTGACCAGCTCTTTGAATCTAAGGCTGAACTAGCAGATCACCAAAAGTTTCCATGCAGTACTCCTCACTCAGCATT
TTCAATGGTTGAAGAGGACTTTCAGCAAAAACTCGAAAGCGAGAATGATCTCCAAGAGATACACACGATCCAGGAGTGTAAGGAATGTGA
CCAAGTTTTTCCTGATTTGCAAAGCCTGGAGAAACACATGCTGTCACATACTGAAGAGAGGGAATACAAGTGTGATCAGTGTCCCAAGGC
ATTTAACTGGAAGTCCAATTTAATTCGCCACCAGATGTCACATGACAGTGGAAAGCACTATGAATGTGAAAACTGTGCCAAGGTTTTCAC
GGACCCTAGCAACCTTCAGCGGCACATTCGCTCTCAGCATGTCGGTGCCCGGGCCCATGCATGCCCGGAGTGTGGCAAAACGTTTGCCAC
TTCGTCGGGCCTCAAACAACACAAGCACATCCACAGCAGTGTGAAGCCCTTTATCTGTGAGGTCTGCCATAAATCCTATACTCAGTTTTC
AAACCTTTGCCGTCATAAGCGCATGCATGCTGATTGCAGAACCCAAATCAAGTGCAAAGACTGTGGACAAATGTTCAGCACTACGTCTTC
CTTAAATAAACACAGGAGGTTTTGTGAGGGCAAGAACCATTTTGCGGCAGGTGGATTTTTTGGCCAAGGCATTTCACTTCCTGGAACCCC
AGCTATGGATAAAACGTCCATGGTTAATATGAGTCATGCCAACCCGGGCCTTGCTGACTATTTTGGCGCCAATAGGCATCCTGCTGGTCT
TACCTTTCCAACAGCTCCTGGATTTTCTTTTAGCTTCCCTGGTCTGTTTCCTTCCGGCTTGTACCACAGGCCTCCTTTGATACCTGCTAG
TTCTCCTGTTAAAGGACTATCAAGTACTGAACAGACAAACAAAAGTCAAAGTCCCCTCATGACACATCCTCAGATACTGCCAGCTACACA
GGATATTTTGAAGGCACTATCTAAACACCCATCTGTAGGGGACAATAAGCCAGTGGAGCTCCAGCCCGAGAGGTCCTCTGAAGAGAGGCC
CTTTGAGAAAATCAGTGACCAGTCAGAGAGTAGTGACCTTGATGATGTCAGTACACCAAGTGGCAGTGACCTGGAAACAACCTCGGGCTC
TGATCTGGAAAGTGACATTGAAAGTGATAAAGAGAAATTTAAAGAAAATGGTAAAATGTTCAAAGACAAAGTAAGCCCTCTTCAGAATCT
GGCTTCAATAAATAATAAGAAAGAATACAGCAATCATTCCATTTTCTCACCATCTTTAGAGGAGCAGACTGCGGTGTCAGGAGCTGTGAA
TGATTCTATAAAGGCTATTGCTTCTATTGCTGAAAAATACTTTGGTTCAACAGGACTGGTGGGGCTGCAAGACAAAAAAGTTGGAGCTTT
ACCTTACCCTTCCATGTTTCCCCTCCCATTTTTTCCAGCATTCTCTCAATCAATGTACCCATTTCCTGATAGAGACTTGAGATCGTTACC
TTTGAAAATGGAACCCCAATCACCAGGTGAAGTAAAGAAACTGCAGAAGGGCAGCTCTGAGTCCCCCTTTGATCTCACCACTAAGCGAAA
GGATGAGAAGCCCTTGACTCCAGTCCCCTCCAAGCCTCCAGTGACACCTGCCACAAGCCAAGACCAGCCCCTGGATCTAAGTATGGGCAG
TAGGAGTAGAGCCAGTGGGACAAAGCTGACTGAGCCTCGAAAAAACCACGTGTTTGGGGGAAAAAAAGGAAGCAACGTCGAATCAAGACC
TGCTTCAGATGGTTCCTTGCAGCATGCAAGACCCACTCCTTTCTTTATGGACCCTATTTACAGAGTAGAGAAAAGAAAACTAACTGACCC
ACTTGAAGCTTTAAAAGAGAAATACTTGAGGCCTTCTCCAGGATTCTTGTTTCACCCACAATTCCAACTGCCTGATCAGAGAACTTGGAT
GTCAGCTATTGAAAACATGGCAGAAAAGCTAGAGAGCTTCAGTGCCCTGAAACCTGAGGCCAGTGAGCTCTTACAGTCAGTGCCCTCTAT
GTTCAACTTCAGGGCGCCTCCCAATGCCCTGCCAGAGAACCTTCTGCGGAAGGGAAAGGAGCGCTATACCTGCAGATACTGTGGCAAGAT
TTTTCCAAGGTCTGCAAACCTAACACGGCACTTGAGAACCCACACAGGAGAGCAGCCTTACAGATGCAAATACTGTGACAGATCATTTAG
CATATCTTCTAACTTGCAAAGGCATGTTCGCAACATCCACAATAAAGAGAAGCCATTTAAGTGTCACTTATGTGATAGGTGTTTTGGTCA
ACAAACCAATTTAGACAGACACCTAAAGAAACATGAGAATGGGAACATGTCCGGTACAGCAACATCGTCGCCTCATTCTGAACTGGAAAG
TACAGGTGCGATTCTGGATGACAAAGAAGATGCTTACTTCACAGAAATTCGAAATTTCATTGGGAACAGCAACCATGGCAGCCAATCTCC
CAGGAATGTGGAGGAGAGGAAAAGAAAATTATTCTTACATATTTTGCTCCAACTCCTGAAGCGTGTAAGCACCTCTGGAAATGTGGAATC
GAGAACCAAGCCTTCTACAAGCTGGAGAAGTCAAGCCAAGTCCGCACAGTGTCCAGCAGCAATTTATTCTTTAAAGGGAGCCGGTTCCGA
TACAGTGGCCGAGTTGCAAAGGAAGTCATGGAATCAAGTGCTAAGATCAAACGGGAGCCACCGGAAATACACAGAGCAGGGATGGTTCCC
AGCCGGAGCTGTCCCTCCATAACCCATGGCCCAAGGCTGAGCAGCGTCCCCAGGACCCGCAGAAGAGCTGTTCACATCTCCATCATGGAA
GGCCTAGAGTCCTTACGGGACAGTGCCCATTCCACACCAGTGCGTTCCACTTCCCATGGGGACACCTTCCTGCCTCACGTGAGAAGCAGC
CGGACAGATAGCAATGAGCGAGTAGCTGTGATTGCAGACGAGGCCTACAGCCCTGCAGACAGCGTGCTGCCCACCCCTGTGGCTGAGCAC
AGCCTGGAGCTGATGTTGCTTTCCCGGCAGATCAATGGAGCCACCTGCAGCATTGAGGAGGAGAAGGAATCTGAAGCCAGCACCCCAACT
GCTACAGAGGTGGAGGCCCTTGGGGGAGAGCTGAGGGCCCTGTGTCAGGGGCACAGCGGGCCCGAGGAGGAACAGAGTGGGCATCTGAAG
GGACCACCGCTACAGCAACAGCAGCATCAGGGGTGGGGTAAGTCTGTCCCCTTAGTCTAGAGCCTAGTGGGCATCACCATAGTTTTGTAT
AATGAAACTAGACTTAACGTGATTTTTTTTTTCCGAAGAACCTCAAGACTTTTATAGTGCTCCAGGGGCGTTAAACGAATTCAGTGGTAC
CAGAGATAGATAGTTCTGTCAGAAATGTTGGACAAAGTGTAGTTAAGAGAAAGCAGAGTTAAGTTACCTGAGAGACTGTTGAGATTTGGA
TAGCAGTGCTTATTTTATATACACCCCCTTGACCCAAAGACTATTTCAATTTATATTTTAACAACGAAATGTTATTTTCTTAACAATTCA
TATTTTGTTTTTACTTTATGGATTAAGAAAATAGAGCCTGATGAACTAAACGATGCAAGAAAGAAACTGATCCTGAGAATGAAAAGCTTC
AGAAAATAGAATTCCAAGATCAACAGCCTTAGAAGGGACCAGGAAAAGAATCTTTTAAAATAGATTTCTAAGAGATGCCTACAAAACACA
GAATGTGACCGTGGCAGAGACCAACACTTAGATGTAGAAATGCTGCCCCCTAGGGTCATCCTCTGCATAAGTTCTAGGAAAGCATCACCA
TCCTTGCAGAGGGAAGTCCTCGAAGCACGCAGCACAGGCATATGAAGGGCGAGTGTGGGATCCTAGGCCCAAGCTCTTCAACTCTAAAAC
CAATCACACACAAGATCCTGTTTTCATCTCAGGGAGAGATTTCTAAGTCATCTGGGGCTTGAGGGCTTATTTAAGGGTGGTCAATGGACA
TATTCCTGGACCCACACAAAAGTAGAGCAGCTGCTGATACCCTAATTGGACAGCCCCAAACGCAGAACAGAACAAGTCACTTGTAGACTT
GACCTCCCCTATTTTGTCCCCCGAGATGGTAGAACCATGTCCATGTTTACAATATGACAACTGTGGAATAATTGGGGTTCTTAGGGAGAG
ATTTGCATAATTTTAAAGACATCCTTTCATCTGGACCAGAGGTCAATCAACTTATGTCAAGTGCTACACAGTAAATATTTTGGTTTAGCA
CGCCATACTGTGTCACAACTGCTCAATTCTGCCATCACAGCACAAAAACAGCCACAGATAATTTGTAAATGAAGGAACATGGCTGTGTTC
CAATAAAACTTTATGAAAACAGTGAGCTGAATTTAGCCTACAGGCCATAATACGCCAATCCTGCTCTAGACAATAAAACTGATCCTTACC
AGTATGTTAGCAGAAGAGGGTCAGTCAGCTCTGTTTCCATGCCTGACATGTATCAAAGATCTGGGACCTCTTCCCAGTGGAGGCACTAGG
GTTGCTTGTTTAAAGGGTGCTTGAACAACTAACCAGCAAAGAGATGTCTGATGCCAAATGGGCAAGATCAAATACTGGAATGCTAAAACA
CAGCTGGAATCTAAGAAGGGAAGAGGGCTTCTCTGACCATTTTCATACCAGCAACAATTTAGGCAGAATTATAAACATCTATTTATCGAG
TGACAATACAAACCGAAGGAGATCCTAGTAGAGATTAGGGGTCAGTTAAAATCAACTAGCCACTGCCACTTGTCATCTACATAGCAAAGG
CTTTATTTAGCACAGGACTAACGTGAAAAGTAGACCCAGAGATGAAAAGGCTGTCAGGAGACAGGGGGCTGGTGTCCACCTGGTATCTAC
TGTCTTATGCAACATAGAAGATTACCTTTTAGTGTAGTGCTCCTACCTCAGTTTGTAGAATCTGGTGTTTCTATGCAGTGAGTGATAGCC
TCAACTCTGACCTTTCATATTCACATTAGAGACAGATGCAGTATTCCATATCCTAGTATGTTCCTTGTGTCTAGAGTTCTAACAGTACAG
TAGTCTATGCCATTTCTAACAGCTAAATTTTGCTCTGTAAACAGAAACTTTAGGGTTGTTTTTTTCCAGGGCTCATCCCAGAAAATATGG
ATAGAAAAGTTTCCTTCAGTTTGCTTTTCAAATAGTGCTTGAATAATAAACCTCCTTTGATTGGTGACTAGTCTTTTTTGGTATATCTCC
ACCTTTAAAAATTGTTCAAGTTTTTAACCTGGTTATACTGTGTTCTAACATGTCTCTCATTTTCTCTCAAAATTAGTTTATCTCATTGTA
GAAAAAGCAATGGTTTTCATAGCTTCATCTATCAGGAAATAAAACTCTTACTAAAGAATAGCATACTGCATCTTTAAGCAGTAGAGGGTA
AACTACCTGCAAATGTGAATTTCTTAGATACATTTAAAAATATATAGTTGTTAACCTTCTGTGTGCCAAAAACTCTTAAGTTACATTTTC
CTTCAAAGCAATGTACTTTTTTCTACATATGCAGTATGTAGTTAGCATAAAATCATTGGTGCCATGAAGATTATTTTTAAACTTAAATAA

>52496_52496_7_MECOM-FRMD5_MECOM_chr3_168810746_ENST00000468789_FRMD5_chr15_44180464_ENST00000402883_length(amino acids)=1078AA_BP=987
MPGHRFYGRPPPPAFFPPRPQSRGALLLIYVAKPGDFLVPPAKRCGLDTSPGWVVRPSILDEFYNVKFCIDASQPDVGSWLKYIRFAGCY
DQHNLVACQINDQIFYRVVADIAPGEELLLFMKSEDYPHETMAPDIHEERQYRCEDCDQLFESKAELADHQKFPCSTPHSAFSMVEEDFQ
QKLESENDLQEIHTIQECKECDQVFPDLQSLEKHMLSHTEEREYKCDQCPKAFNWKSNLIRHQMSHDSGKHYECENCAKVFTDPSNLQRH
IRSQHVGARAHACPECGKTFATSSGLKQHKHIHSSVKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFC
EGKNHFAAGGFFGQGISLPGTPAMDKTSMVNMSHANPGLADYFGANRHPAGLTFPTAPGFSFSFPGLFPSGLYHRPPLIPASSPVKGLSS
TEQTNKSQSPLMTHPQILPATQDILKALSKHPSVGDNKPVELQPERSSEERPFEKISDQSESSDLDDVSTPSGSDLETTSGSDLESDIES
DKEKFKENGKMFKDKVSPLQNLASINNKKEYSNHSIFSPSLEEQTAVSGAVNDSIKAIASIAEKYFGSTGLVGLQDKKVGALPYPSMFPL
PFFPAFSQSMYPFPDRDLRSLPLKMEPQSPGEVKKLQKGSSESPFDLTTKRKDEKPLTPVPSKPPVTPATSQDQPLDLSMGSRSRASGTK
LTEPRKNHVFGGKKGSNVESRPASDGSLQHARPTPFFMDPIYRVEKRKLTDPLEALKEKYLRPSPGFLFHPQFQLPDQRTWMSAIENMAE
KLESFSALKPEASELLQSVPSMFNFRAPPNALPENLLRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRH
VRNIHNKEKPFKCHLCDRCFGQQTNLDRHLKKHENGNMSGTATSSPHSELESTGAILDDKEDAYFTEIRNFIGNSNHGSQSPRNVEERKR

--------------------------------------------------------------
>52496_52496_8_MECOM-FRMD5_MECOM_chr3_168810746_ENST00000468789_FRMD5_chr15_44180464_ENST00000417257_length(transcript)=7030nt_BP=2988nt
AAAGTTTGTCACTTCGGACAGTTTCCTGCCGGGGCACCGTTTCTACGGGCGCCCCCCGCCCCCAGCCTTCTTTCCTCCTCGCCCGCAGTC
TCGCGGAGCCCTGCTGCTTATCTACGTTGCTAAGCCGGGCGATTTCCTTGTTCCTCCTGCGAAACGGTGCGGTCTGGACACGTCTCCGGG
GTGGGTCGTCCGGCCTTCGATCTTAGACGAATTTTACAATGTGAAGTTCTGCATAGATGCCAGTCAACCAGATGTTGGAAGCTGGCTCAA
GTACATTAGATTCGCTGGCTGTTATGATCAGCACAACCTTGTTGCATGCCAGATAAATGATCAGATATTCTATAGAGTAGTTGCAGACAT
TGCGCCGGGAGAGGAGCTTCTGCTGTTCATGAAGAGCGAAGACTATCCCCATGAAACTATGGCGCCGGATATCCACGAAGAACGGCAATA
TCGCTGCGAAGACTGTGACCAGCTCTTTGAATCTAAGGCTGAACTAGCAGATCACCAAAAGTTTCCATGCAGTACTCCTCACTCAGCATT
TTCAATGGTTGAAGAGGACTTTCAGCAAAAACTCGAAAGCGAGAATGATCTCCAAGAGATACACACGATCCAGGAGTGTAAGGAATGTGA
CCAAGTTTTTCCTGATTTGCAAAGCCTGGAGAAACACATGCTGTCACATACTGAAGAGAGGGAATACAAGTGTGATCAGTGTCCCAAGGC
ATTTAACTGGAAGTCCAATTTAATTCGCCACCAGATGTCACATGACAGTGGAAAGCACTATGAATGTGAAAACTGTGCCAAGGTTTTCAC
GGACCCTAGCAACCTTCAGCGGCACATTCGCTCTCAGCATGTCGGTGCCCGGGCCCATGCATGCCCGGAGTGTGGCAAAACGTTTGCCAC
TTCGTCGGGCCTCAAACAACACAAGCACATCCACAGCAGTGTGAAGCCCTTTATCTGTGAGGTCTGCCATAAATCCTATACTCAGTTTTC
AAACCTTTGCCGTCATAAGCGCATGCATGCTGATTGCAGAACCCAAATCAAGTGCAAAGACTGTGGACAAATGTTCAGCACTACGTCTTC
CTTAAATAAACACAGGAGGTTTTGTGAGGGCAAGAACCATTTTGCGGCAGGTGGATTTTTTGGCCAAGGCATTTCACTTCCTGGAACCCC
AGCTATGGATAAAACGTCCATGGTTAATATGAGTCATGCCAACCCGGGCCTTGCTGACTATTTTGGCGCCAATAGGCATCCTGCTGGTCT
TACCTTTCCAACAGCTCCTGGATTTTCTTTTAGCTTCCCTGGTCTGTTTCCTTCCGGCTTGTACCACAGGCCTCCTTTGATACCTGCTAG
TTCTCCTGTTAAAGGACTATCAAGTACTGAACAGACAAACAAAAGTCAAAGTCCCCTCATGACACATCCTCAGATACTGCCAGCTACACA
GGATATTTTGAAGGCACTATCTAAACACCCATCTGTAGGGGACAATAAGCCAGTGGAGCTCCAGCCCGAGAGGTCCTCTGAAGAGAGGCC
CTTTGAGAAAATCAGTGACCAGTCAGAGAGTAGTGACCTTGATGATGTCAGTACACCAAGTGGCAGTGACCTGGAAACAACCTCGGGCTC
TGATCTGGAAAGTGACATTGAAAGTGATAAAGAGAAATTTAAAGAAAATGGTAAAATGTTCAAAGACAAAGTAAGCCCTCTTCAGAATCT
GGCTTCAATAAATAATAAGAAAGAATACAGCAATCATTCCATTTTCTCACCATCTTTAGAGGAGCAGACTGCGGTGTCAGGAGCTGTGAA
TGATTCTATAAAGGCTATTGCTTCTATTGCTGAAAAATACTTTGGTTCAACAGGACTGGTGGGGCTGCAAGACAAAAAAGTTGGAGCTTT
ACCTTACCCTTCCATGTTTCCCCTCCCATTTTTTCCAGCATTCTCTCAATCAATGTACCCATTTCCTGATAGAGACTTGAGATCGTTACC
TTTGAAAATGGAACCCCAATCACCAGGTGAAGTAAAGAAACTGCAGAAGGGCAGCTCTGAGTCCCCCTTTGATCTCACCACTAAGCGAAA
GGATGAGAAGCCCTTGACTCCAGTCCCCTCCAAGCCTCCAGTGACACCTGCCACAAGCCAAGACCAGCCCCTGGATCTAAGTATGGGCAG
TAGGAGTAGAGCCAGTGGGACAAAGCTGACTGAGCCTCGAAAAAACCACGTGTTTGGGGGAAAAAAAGGAAGCAACGTCGAATCAAGACC
TGCTTCAGATGGTTCCTTGCAGCATGCAAGACCCACTCCTTTCTTTATGGACCCTATTTACAGAGTAGAGAAAAGAAAACTAACTGACCC
ACTTGAAGCTTTAAAAGAGAAATACTTGAGGCCTTCTCCAGGATTCTTGTTTCACCCACAATTCCAACTGCCTGATCAGAGAACTTGGAT
GTCAGCTATTGAAAACATGGCAGAAAAGCTAGAGAGCTTCAGTGCCCTGAAACCTGAGGCCAGTGAGCTCTTACAGTCAGTGCCCTCTAT
GTTCAACTTCAGGGCGCCTCCCAATGCCCTGCCAGAGAACCTTCTGCGGAAGGGAAAGGAGCGCTATACCTGCAGATACTGTGGCAAGAT
TTTTCCAAGGTCTGCAAACCTAACACGGCACTTGAGAACCCACACAGGAGAGCAGCCTTACAGATGCAAATACTGTGACAGATCATTTAG
CATATCTTCTAACTTGCAAAGGCATGTTCGCAACATCCACAATAAAGAGAAGCCATTTAAGTGTCACTTATGTGATAGGTGTTTTGGTCA
ACAAACCAATTTAGACAGACACCTAAAGAAACATGAGAATGGGAACATGTCCGGTACAGCAACATCGTCGCCTCATTCTGAACTGGAAAG
TACAGGTGCGATTCTGGATGACAAAGAAGATGCTTACTTCACAGAAATTCGAAATTTCATTGGGAACAGCAACCATGGCAGCCAATCTCC
CAGGAATGTGGAGGAGAGGAAAAGAAAATTATTCTTACATATTTTGCTCCAACTCCTGAAGCGTGTAAGCACCTCTGGAAATGTGGAATC
GAGAACCAAGCCTTCTACAAGCTGGAGAAGTCAAGCCAAGTCCGCACAGTGTCCAGCAGCAATTTATTCTTTAAAGGGAGCCGGTTCCGA
TACAGTGGCCGAGTTGCAAAGGAAGTCATGGAATCAAGTGCTAAGATCAAACGGGAGCCACCGGAAATACACAGAGCAGGGATGGTTCCC
AGCCGGAGCTGTCCCTCCATAACCCATGGCCCAAGGCTGAGCAGCGTCCCCAGGACCCGCAGAAGAGCTGTTCACATCTCCATCATGGAA
GGCCTAGAGTCCTTACGGGACAGTGCCCATTCCACACCAGTGCGTTCCACTTCCCATGGGGACACCTTCCTGCCTCACGTGAGAAGCAGC
CGGACAGATAGCAATGAGCGAGTAGCTGTGATTGCAGACGAGGCCTACAGCCCTGCAGACAGCGTGCTGCCCACCCCTGTGGCTGAGCAC
AGCCTGGAGCTGATGTTGCTTTCCCGGCAGATCAATGGAGCCACCTGCAGCATTGAGGAGGAGAAGGAATCTGAAGCCAGCACCCCAACT
GCTACAGAGGTGGAGGCCCTTGGGGGAGAGCTGAGGGCCCTGTGTCAGGGGCACAGCGGGCCCGAGGAGGAACAGGTGAATAAGTTTGTT
CTAAGTGTCCTCCGTTTGCTCCTTGTGACCATGGGACTCCTCTTTGTTTTGCTCCTCCTCCTGATCATCCTTACCGAGTCTGACCTTGAC
ATTGCCTTTTTCCGTGATATCCGCCAGACCCCCGAGTTTGAACAATTCCACTATCAATACTTTTGTCCCCTCAGGCGATGGTTTGCCTGC
AAAATCCGCTCAGTGGTGAGCCTGCTCATTGACACCTGAGAAGGCATGACTCCTCCCAAAAACTAGCCAGGTGGACCAAGGAACCCGGCT
ACCCATTCCCAGCAATGGGACCCATCGCGGAACCATCGGCACATATACCAAGTCCTCCTCTCATGACTCAAAGTCCACTGCAGCCTAGGA
GGGTGTTTCCCAGAAGAAGAAAGGGATAGGCTCATGCCCTGTCTAAACAAACTGGGAAAACTCATTTTCTTCAGAAGTTATTTCAAGAAA
GGCTCAGCGACTCTGTTTCTCATCTTTCCAATTTGCAGGATAATTTTTGGTTTTGAATTTTGATTTTTCATAGATGTATATTATTTTGAA
GTATCAAATAAAAATAATTTATTTTACTATTACTGATTATTGCAGTAGTATCACCTAGCAGAGGGGACACTAGTTGAAAACTAGAGAGCT
GCTGTCCTCTGTATTCTGCAGGAGCTTTTCCTGCTGGTGCCACTGGGTTCCAGTAGACTCATCACTGCAGCCTCAGCAGGGCAGGCCAGG
GATCTGGACAATGGGGACTGTTTAGTTTTTTGTTTGTTTTTTTTGCCAGCCAGAACTTTTAAAAAAGTAAACATCCATGTAGAATGATTA
AATGGAAAGTTGCTTCTTATGATGGTCTGAGTTGGATTTTCTTTTCCTTTTGTTTTTTCAAATCTGAGCAGAGTGGGCATCTGAAGGGAC
CACCGCTACAGCAACAGCAGCATCAGGGGTGGGGTAAGTCTGTCCCCTTAGTCTAGAGCCTAGTGGGCATCACCATAGTTTTGTATAATG
AAACTAGACTTAACGTGATTTTTTTTTTCCGAAGAACCTCAAGACTTTTATAGTGCTCCAGGGGCGTTAAACGAATTCAGTGGTACCAGA
GATAGATAGTTCTGTCAGAAATGTTGGACAAAGTGTAGTTAAGAGAAAGCAGAGTTAAGTTACCTGAGAGACTGTTGAGATTTGGATAGC
AGTGCTTATTTTATATACACCCCCTTGACCCAAAGACTATTTCAATTTATATTTTAACAACGAAATGTTATTTTCTTAACAATTCATATT
TTGTTTTTACTTTATGGATTAAGAAAATAGAGCCTGATGAACTAAACGATGCAAGAAAGAAACTGATCCTGAGAATGAAAAGCTTCAGAA
AATAGAATTCCAAGATCAACAGCCTTAGAAGGGACCAGGAAAAGAATCTTTTAAAATAGATTTCTAAGAGATGCCTACAAAACACAGAAT
GTGACCGTGGCAGAGACCAACACTTAGATGTAGAAATGCTGCCCCCTAGGGTCATCCTCTGCATAAGTTCTAGGAAAGCATCACCATCCT
TGCAGAGGGAAGTCCTCGAAGCACGCAGCACAGGCATATGAAGGGCGAGTGTGGGATCCTAGGCCCAAGCTCTTCAACTCTAAAACCAAT
CACACACAAGATCCTGTTTTCATCTCAGGGAGAGATTTCTAAGTCATCTGGGGCTTGAGGGCTTATTTAAGGGTGGTCAATGGACATATT
CCTGGACCCACACAAAAGTAGAGCAGCTGCTGATACCCTAATTGGACAGCCCCAAACGCAGAACAGAACAAGTCACTTGTAGACTTGACC
TCCCCTATTTTGTCCCCCGAGATGGTAGAACCATGTCCATGTTTACAATATGACAACTGTGGAATAATTGGGGTTCTTAGGGAGAGATTT
GCATAATTTTAAAGACATCCTTTCATCTGGACCAGAGGTCAATCAACTTATGTCAAGTGCTACACAGTAAATATTTTGGTTTAGCACGCC
ATACTGTGTCACAACTGCTCAATTCTGCCATCACAGCACAAAAACAGCCACAGATAATTTGTAAATGAAGGAACATGGCTGTGTTCCAAT
AAAACTTTATGAAAACAGTGAGCTGAATTTAGCCTACAGGCCATAATACGCCAATCCTGCTCTAGACAATAAAACTGATCCTTACCAGTA
TGTTAGCAGAAGAGGGTCAGTCAGCTCTGTTTCCATGCCTGACATGTATCAAAGATCTGGGACCTCTTCCCAGTGGAGGCACTAGGGTTG
CTTGTTTAAAGGGTGCTTGAACAACTAACCAGCAAAGAGATGTCTGATGCCAAATGGGCAAGATCAAATACTGGAATGCTAAAACACAGC
TGGAATCTAAGAAGGGAAGAGGGCTTCTCTGACCATTTTCATACCAGCAACAATTTAGGCAGAATTATAAACATCTATTTATCGAGTGAC
AATACAAACCGAAGGAGATCCTAGTAGAGATTAGGGGTCAGTTAAAATCAACTAGCCACTGCCACTTGTCATCTACATAGCAAAGGCTTT
ATTTAGCACAGGACTAACGTGAAAAGTAGACCCAGAGATGAAAAGGCTGTCAGGAGACAGGGGGCTGGTGTCCACCTGGTATCTACTGTC
TTATGCAACATAGAAGATTACCTTTTAGTGTAGTGCTCCTACCTCAGTTTGTAGAATCTGGTGTTTCTATGCAGTGAGTGATAGCCTCAA
CTCTGACCTTTCATATTCACATTAGAGACAGATGCAGTATTCCATATCCTAGTATGTTCCTTGTGTCTAGAGTTCTAACAGTACAGTAGT
CTATGCCATTTCTAACAGCTAAATTTTGCTCTGTAAACAGAAACTTTAGGGTTGTTTTTTTCCAGGGCTCATCCCAGAAAATATGGATAG
AAAAGTTTCCTTCAGTTTGCTTTTCAAATAGTGCTTGAATAATAAACCTCCTTTGATTGGTGACTAGTCTTTTTTGGTATATCTCCACCT
TTAAAAATTGTTCAAGTTTTTAACCTGGTTATACTGTGTTCTAACATGTCTCTCATTTTCTCTCAAAATTAGTTTATCTCATTGTAGAAA
AAGCAATGGTTTTCATAGCTTCATCTATCAGGAAATAAAACTCTTACTAAAGAATAGCATACTGCATCTTTAAGCAGTAGAGGGTAAACT
ACCTGCAAATGTGAATTTCTTAGATACATTTAAAAATATATAGTTGTTAACCTTCTGTGTGCCAAAAACTCTTAAGTTACATTTTCCTTC
AAAGCAATGTACTTTTTTCTACATATGCAGTATGTAGTTAGCATAAAATCATTGGTGCCATGAAGATTATTTTTAAACTTAAATAAATAT

>52496_52496_8_MECOM-FRMD5_MECOM_chr3_168810746_ENST00000468789_FRMD5_chr15_44180464_ENST00000417257_length(amino acids)=1078AA_BP=987
MPGHRFYGRPPPPAFFPPRPQSRGALLLIYVAKPGDFLVPPAKRCGLDTSPGWVVRPSILDEFYNVKFCIDASQPDVGSWLKYIRFAGCY
DQHNLVACQINDQIFYRVVADIAPGEELLLFMKSEDYPHETMAPDIHEERQYRCEDCDQLFESKAELADHQKFPCSTPHSAFSMVEEDFQ
QKLESENDLQEIHTIQECKECDQVFPDLQSLEKHMLSHTEEREYKCDQCPKAFNWKSNLIRHQMSHDSGKHYECENCAKVFTDPSNLQRH
IRSQHVGARAHACPECGKTFATSSGLKQHKHIHSSVKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFC
EGKNHFAAGGFFGQGISLPGTPAMDKTSMVNMSHANPGLADYFGANRHPAGLTFPTAPGFSFSFPGLFPSGLYHRPPLIPASSPVKGLSS
TEQTNKSQSPLMTHPQILPATQDILKALSKHPSVGDNKPVELQPERSSEERPFEKISDQSESSDLDDVSTPSGSDLETTSGSDLESDIES
DKEKFKENGKMFKDKVSPLQNLASINNKKEYSNHSIFSPSLEEQTAVSGAVNDSIKAIASIAEKYFGSTGLVGLQDKKVGALPYPSMFPL
PFFPAFSQSMYPFPDRDLRSLPLKMEPQSPGEVKKLQKGSSESPFDLTTKRKDEKPLTPVPSKPPVTPATSQDQPLDLSMGSRSRASGTK
LTEPRKNHVFGGKKGSNVESRPASDGSLQHARPTPFFMDPIYRVEKRKLTDPLEALKEKYLRPSPGFLFHPQFQLPDQRTWMSAIENMAE
KLESFSALKPEASELLQSVPSMFNFRAPPNALPENLLRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRH
VRNIHNKEKPFKCHLCDRCFGQQTNLDRHLKKHENGNMSGTATSSPHSELESTGAILDDKEDAYFTEIRNFIGNSNHGSQSPRNVEERKR

--------------------------------------------------------------
>52496_52496_9_MECOM-FRMD5_MECOM_chr3_168810746_ENST00000468789_FRMD5_chr15_44180464_ENST00000484674_length(transcript)=4340nt_BP=2988nt
AAAGTTTGTCACTTCGGACAGTTTCCTGCCGGGGCACCGTTTCTACGGGCGCCCCCCGCCCCCAGCCTTCTTTCCTCCTCGCCCGCAGTC
TCGCGGAGCCCTGCTGCTTATCTACGTTGCTAAGCCGGGCGATTTCCTTGTTCCTCCTGCGAAACGGTGCGGTCTGGACACGTCTCCGGG
GTGGGTCGTCCGGCCTTCGATCTTAGACGAATTTTACAATGTGAAGTTCTGCATAGATGCCAGTCAACCAGATGTTGGAAGCTGGCTCAA
GTACATTAGATTCGCTGGCTGTTATGATCAGCACAACCTTGTTGCATGCCAGATAAATGATCAGATATTCTATAGAGTAGTTGCAGACAT
TGCGCCGGGAGAGGAGCTTCTGCTGTTCATGAAGAGCGAAGACTATCCCCATGAAACTATGGCGCCGGATATCCACGAAGAACGGCAATA
TCGCTGCGAAGACTGTGACCAGCTCTTTGAATCTAAGGCTGAACTAGCAGATCACCAAAAGTTTCCATGCAGTACTCCTCACTCAGCATT
TTCAATGGTTGAAGAGGACTTTCAGCAAAAACTCGAAAGCGAGAATGATCTCCAAGAGATACACACGATCCAGGAGTGTAAGGAATGTGA
CCAAGTTTTTCCTGATTTGCAAAGCCTGGAGAAACACATGCTGTCACATACTGAAGAGAGGGAATACAAGTGTGATCAGTGTCCCAAGGC
ATTTAACTGGAAGTCCAATTTAATTCGCCACCAGATGTCACATGACAGTGGAAAGCACTATGAATGTGAAAACTGTGCCAAGGTTTTCAC
GGACCCTAGCAACCTTCAGCGGCACATTCGCTCTCAGCATGTCGGTGCCCGGGCCCATGCATGCCCGGAGTGTGGCAAAACGTTTGCCAC
TTCGTCGGGCCTCAAACAACACAAGCACATCCACAGCAGTGTGAAGCCCTTTATCTGTGAGGTCTGCCATAAATCCTATACTCAGTTTTC
AAACCTTTGCCGTCATAAGCGCATGCATGCTGATTGCAGAACCCAAATCAAGTGCAAAGACTGTGGACAAATGTTCAGCACTACGTCTTC
CTTAAATAAACACAGGAGGTTTTGTGAGGGCAAGAACCATTTTGCGGCAGGTGGATTTTTTGGCCAAGGCATTTCACTTCCTGGAACCCC
AGCTATGGATAAAACGTCCATGGTTAATATGAGTCATGCCAACCCGGGCCTTGCTGACTATTTTGGCGCCAATAGGCATCCTGCTGGTCT
TACCTTTCCAACAGCTCCTGGATTTTCTTTTAGCTTCCCTGGTCTGTTTCCTTCCGGCTTGTACCACAGGCCTCCTTTGATACCTGCTAG
TTCTCCTGTTAAAGGACTATCAAGTACTGAACAGACAAACAAAAGTCAAAGTCCCCTCATGACACATCCTCAGATACTGCCAGCTACACA
GGATATTTTGAAGGCACTATCTAAACACCCATCTGTAGGGGACAATAAGCCAGTGGAGCTCCAGCCCGAGAGGTCCTCTGAAGAGAGGCC
CTTTGAGAAAATCAGTGACCAGTCAGAGAGTAGTGACCTTGATGATGTCAGTACACCAAGTGGCAGTGACCTGGAAACAACCTCGGGCTC
TGATCTGGAAAGTGACATTGAAAGTGATAAAGAGAAATTTAAAGAAAATGGTAAAATGTTCAAAGACAAAGTAAGCCCTCTTCAGAATCT
GGCTTCAATAAATAATAAGAAAGAATACAGCAATCATTCCATTTTCTCACCATCTTTAGAGGAGCAGACTGCGGTGTCAGGAGCTGTGAA
TGATTCTATAAAGGCTATTGCTTCTATTGCTGAAAAATACTTTGGTTCAACAGGACTGGTGGGGCTGCAAGACAAAAAAGTTGGAGCTTT
ACCTTACCCTTCCATGTTTCCCCTCCCATTTTTTCCAGCATTCTCTCAATCAATGTACCCATTTCCTGATAGAGACTTGAGATCGTTACC
TTTGAAAATGGAACCCCAATCACCAGGTGAAGTAAAGAAACTGCAGAAGGGCAGCTCTGAGTCCCCCTTTGATCTCACCACTAAGCGAAA
GGATGAGAAGCCCTTGACTCCAGTCCCCTCCAAGCCTCCAGTGACACCTGCCACAAGCCAAGACCAGCCCCTGGATCTAAGTATGGGCAG
TAGGAGTAGAGCCAGTGGGACAAAGCTGACTGAGCCTCGAAAAAACCACGTGTTTGGGGGAAAAAAAGGAAGCAACGTCGAATCAAGACC
TGCTTCAGATGGTTCCTTGCAGCATGCAAGACCCACTCCTTTCTTTATGGACCCTATTTACAGAGTAGAGAAAAGAAAACTAACTGACCC
ACTTGAAGCTTTAAAAGAGAAATACTTGAGGCCTTCTCCAGGATTCTTGTTTCACCCACAATTCCAACTGCCTGATCAGAGAACTTGGAT
GTCAGCTATTGAAAACATGGCAGAAAAGCTAGAGAGCTTCAGTGCCCTGAAACCTGAGGCCAGTGAGCTCTTACAGTCAGTGCCCTCTAT
GTTCAACTTCAGGGCGCCTCCCAATGCCCTGCCAGAGAACCTTCTGCGGAAGGGAAAGGAGCGCTATACCTGCAGATACTGTGGCAAGAT
TTTTCCAAGGTCTGCAAACCTAACACGGCACTTGAGAACCCACACAGGAGAGCAGCCTTACAGATGCAAATACTGTGACAGATCATTTAG
CATATCTTCTAACTTGCAAAGGCATGTTCGCAACATCCACAATAAAGAGAAGCCATTTAAGTGTCACTTATGTGATAGGTGTTTTGGTCA
ACAAACCAATTTAGACAGACACCTAAAGAAACATGAGAATGGGAACATGTCCGGTACAGCAACATCGTCGCCTCATTCTGAACTGGAAAG
TACAGGTGCGATTCTGGATGACAAAGAAGATGCTTACTTCACAGAAATTCGAAATTTCATTGGGAACAGCAACCATGGCAGCCAATCTCC
CAGGAATGTGGAGGAGAGGAAAAGAAAATTATTCTTACATATTTTGCTCCAACTCCTGAAGCGTGTAAGCACCTCTGGAAATGTGGAATC
GAGAACCAAGCCTTCTACAAGCTGGAGAAGTCAAGCCAAGTCCGCACAGTGTCCAGCAGCAATTTATTCTTTAAAGGGAGCCGGTTCCGA
TACAGTGGCCGAGTTGCAAAGGAAGTCATGGAATCAAGTGCTAAGATCAAACGGGAGCCACCGGAAATACACAGAGCAGGGATGGTTCCC
AGCCGGAGCTGTCCCTCCATAACCCATGGCCCAAGGCTGAGCAGCGTCCCCAGGACCCGCAGAAGAGCTGTTCACATCTCCATCATGGAA
GGCCTAGAGTCCTTACGGGACAGTGCCCATTCCACACCAGTGCGTTCCACTTCCCATGGGGACACCTTCCTGCCTCACGTGAGAAGCAGC
CGGACAGATAGCAATGAGCGAGTAGCTGTGATTGCAGACGAGGCCTACAGCCCTGCAGACAGCGTGCTGCCCACCCCTGTGGCTGAGCAC
AGCCTGGAGCTGATGTTGCTTTCCCGGCAGATCAATGGAGCCACCTGCAGCATTGAGGAGGAGAAGGAATCTGAAGCCAGCACCCCAACT
GCTACAGAGGTGGAGGCCCTTGGGGGAGAGCTGAGGGCCCTGTGTCAGGGGCACAGCGGGCCCGAGGAGGAACAGGCGATGGTTTGCCTG
CAAAATCCGCTCAGTGGTGAGCCTGCTCATTGACACCTGAGAAGGCATGACTCCTCCCAAAAACTAGCCAGGTGGACCAAGGAACCCGGC
TACCCATTCCCAGCAATGGGACCCATCGCGGAACCATCGGCACATATACCAAGTCCTCCTCTCATGACTCAAAGTCCACTGCAGCCTAGG
AGGGTGTTTCCCAGAAGAAGAAAGGGATAGGCTCATGCCCTGTCTAAACAAACTGGGAAAACTCATTTTCTTCAGAAGTTATTTCAAGAA
AGGCTCAGCGACTCTGTTTCTCATCTTTCCAATTTGCAGGATAATTTTTGGTTTTGAATTTTGATTTTTCATAGATGTATATTATTTTGA
AGTATCAAATAAAAATAATTTATTTTACTATTACTGATTATTGCAGTAGTATCACCTAGCAGAGGGGACACTAGTTGAAAACTAGAGAGC
TGCTGTCCTCTGTATTCTGCAGGAGCTTTTCCTGCTGGTGCCACTGGGTTCCAGTAGACTCATCACTGCAGCCTCAGCAGGGCAGGCCAG
GGATCTGGACAATGGGGACTGTTTAGTTTTTTGTTTGTTTTTTTTGCCAGCCAGAACTTTTAAAAAAGTAAACATCCATGTAGAATGATT

>52496_52496_9_MECOM-FRMD5_MECOM_chr3_168810746_ENST00000468789_FRMD5_chr15_44180464_ENST00000484674_length(amino acids)=1078AA_BP=987
MPGHRFYGRPPPPAFFPPRPQSRGALLLIYVAKPGDFLVPPAKRCGLDTSPGWVVRPSILDEFYNVKFCIDASQPDVGSWLKYIRFAGCY
DQHNLVACQINDQIFYRVVADIAPGEELLLFMKSEDYPHETMAPDIHEERQYRCEDCDQLFESKAELADHQKFPCSTPHSAFSMVEEDFQ
QKLESENDLQEIHTIQECKECDQVFPDLQSLEKHMLSHTEEREYKCDQCPKAFNWKSNLIRHQMSHDSGKHYECENCAKVFTDPSNLQRH
IRSQHVGARAHACPECGKTFATSSGLKQHKHIHSSVKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFC
EGKNHFAAGGFFGQGISLPGTPAMDKTSMVNMSHANPGLADYFGANRHPAGLTFPTAPGFSFSFPGLFPSGLYHRPPLIPASSPVKGLSS
TEQTNKSQSPLMTHPQILPATQDILKALSKHPSVGDNKPVELQPERSSEERPFEKISDQSESSDLDDVSTPSGSDLETTSGSDLESDIES
DKEKFKENGKMFKDKVSPLQNLASINNKKEYSNHSIFSPSLEEQTAVSGAVNDSIKAIASIAEKYFGSTGLVGLQDKKVGALPYPSMFPL
PFFPAFSQSMYPFPDRDLRSLPLKMEPQSPGEVKKLQKGSSESPFDLTTKRKDEKPLTPVPSKPPVTPATSQDQPLDLSMGSRSRASGTK
LTEPRKNHVFGGKKGSNVESRPASDGSLQHARPTPFFMDPIYRVEKRKLTDPLEALKEKYLRPSPGFLFHPQFQLPDQRTWMSAIENMAE
KLESFSALKPEASELLQSVPSMFNFRAPPNALPENLLRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRH
VRNIHNKEKPFKCHLCDRCFGQQTNLDRHLKKHENGNMSGTATSSPHSELESTGAILDDKEDAYFTEIRNFIGNSNHGSQSPRNVEERKR

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Fusion Gene PPI Analysis for MECOM-FRMD5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneMECOMchr3:168810746chr15:44180464ENST00000264674-1417189_440931.66666666666661117.0MAPK9%2C SMAD3 and probably SUV39H1
HgeneMECOMchr3:168810746chr15:44180464ENST00000392736-1316189_440866.66666666666661052.0MAPK9%2C SMAD3 and probably SUV39H1
HgeneMECOMchr3:168810746chr15:44180464ENST00000433243-1417189_440867.66666666666661053.0MAPK9%2C SMAD3 and probably SUV39H1
HgeneMECOMchr3:168810746chr15:44180464ENST00000464456-1215189_440857.66666666666661043.0MAPK9%2C SMAD3 and probably SUV39H1
HgeneMECOMchr3:168810746chr15:44180464ENST00000468789-1316189_440866.66666666666661052.0MAPK9%2C SMAD3 and probably SUV39H1
HgeneMECOMchr3:168810746chr15:44180464ENST00000472280-1316189_440867.66666666666661053.0MAPK9%2C SMAD3 and probably SUV39H1
TgeneFRMD5chr3:168810746chr15:44180464ENST00000417257814308_353264.0571.0ROCK1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MECOM-FRMD5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MECOM-FRMD5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource