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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Fusion gene:MECOM-GOLIM4 (FusionGDB2 ID:52497)

Fusion Gene Summary for MECOM-GOLIM4

check button Fusion gene summary
Fusion gene informationFusion gene name: MECOM-GOLIM4
Fusion gene ID: 52497
HgeneTgene
Gene symbol

MECOM

GOLIM4

Gene ID

2122

27333

Gene nameMDS1 and EVI1 complex locusgolgi integral membrane protein 4
SynonymsAML1-EVI-1|EVI1|KMT8E|MDS1|MDS1-EVI1|PRDM3|RUSAT2GIMPC|GOLPH4|GPP130|P138
Cytomap

3q26.2

3q26.2

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase MECOMAML1-EVI-1 fusion proteinMDS1 and EVI1 complex locus protein EVI1MDS1 and EVI1 complex locus protein MDS1PR domain 3ecotropic virus integration site 1 protein homologmyelodysplasia syndrome-associated protein Golgi integral membrane protein 4130 kDa golgi-localized phosphoproteincis Golgi-localized calcium-binding proteingolgi integral membrane protein, cisgolgi phosphoprotein 4golgi phosphoprotein of 130 kDagolgi-localized phosphoprotein of 130 kDatype
Modification date2020031320200313
UniProtAcc

Q03112

O00461

Ensembl transtripts involved in fusion geneENST00000485957, ENST00000494292, 
ENST00000264674, ENST00000392736, 
ENST00000433243, ENST00000460814, 
ENST00000464456, ENST00000468789, 
ENST00000472280, 		ENST00000309027, 
ENST00000470487, 
Fusion gene scores* DoF score33 X 21 X 11=76237 X 6 X 5=210
# samples 437
** MAII scorelog2(43/7623*10)=-4.14795031118505
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MECOM [Title/Abstract] AND GOLIM4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGOLIM4(167742314)-MECOM(168861620), # samples:3
MECOM(169098975)-GOLIM4(167728611), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMECOM

GO:0045892

negative regulation of transcription, DNA-templated

10856240|11568182

HgeneMECOM

GO:0045893

positive regulation of transcription, DNA-templated

11568182|19767769

HgeneMECOM

GO:0051726

regulation of cell cycle

11568182


check buttonFusion gene breakpoints across MECOM (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GOLIM4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-W3-A828-06AMECOMchr3

169098975

-GOLIM4chr3

167728611

-


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Fusion Gene ORF analysis for MECOM-GOLIM4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000485957ENST00000309027MECOMchr3

169098975

-GOLIM4chr3

167728611

-
5UTR-3CDSENST00000485957ENST00000470487MECOMchr3

169098975

-GOLIM4chr3

167728611

-
In-frameENST00000494292ENST00000309027MECOMchr3

169098975

-GOLIM4chr3

167728611

-
In-frameENST00000494292ENST00000470487MECOMchr3

169098975

-GOLIM4chr3

167728611

-
intron-3CDSENST00000264674ENST00000309027MECOMchr3

169098975

-GOLIM4chr3

167728611

-
intron-3CDSENST00000264674ENST00000470487MECOMchr3

169098975

-GOLIM4chr3

167728611

-
intron-3CDSENST00000392736ENST00000309027MECOMchr3

169098975

-GOLIM4chr3

167728611

-
intron-3CDSENST00000392736ENST00000470487MECOMchr3

169098975

-GOLIM4chr3

167728611

-
intron-3CDSENST00000433243ENST00000309027MECOMchr3

169098975

-GOLIM4chr3

167728611

-
intron-3CDSENST00000433243ENST00000470487MECOMchr3

169098975

-GOLIM4chr3

167728611

-
intron-3CDSENST00000460814ENST00000309027MECOMchr3

169098975

-GOLIM4chr3

167728611

-
intron-3CDSENST00000460814ENST00000470487MECOMchr3

169098975

-GOLIM4chr3

167728611

-
intron-3CDSENST00000464456ENST00000309027MECOMchr3

169098975

-GOLIM4chr3

167728611

-
intron-3CDSENST00000464456ENST00000470487MECOMchr3

169098975

-GOLIM4chr3

167728611

-
intron-3CDSENST00000468789ENST00000309027MECOMchr3

169098975

-GOLIM4chr3

167728611

-
intron-3CDSENST00000468789ENST00000470487MECOMchr3

169098975

-GOLIM4chr3

167728611

-
intron-3CDSENST00000472280ENST00000309027MECOMchr3

169098975

-GOLIM4chr3

167728611

-
intron-3CDSENST00000472280ENST00000470487MECOMchr3

169098975

-GOLIM4chr3

167728611

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000494292MECOMchr3169098975-ENST00000470487GOLIM4chr3167728611-229647398703201
ENST00000494292MECOMchr3169098975-ENST00000309027GOLIM4chr3167728611-73847398703201

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000494292ENST00000470487MECOMchr3169098975-GOLIM4chr3167728611-0.0006791820.99932086
ENST00000494292ENST00000309027MECOMchr3169098975-GOLIM4chr3167728611-0.0041451650.9958548

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Fusion Genomic Features for MECOM-GOLIM4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MECOM-GOLIM4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:167742314/chr3:168861620)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MECOM

Q03112

GOLIM4

O00461

FUNCTION: [Isoform 1]: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. {ECO:0000269|PubMed:10856240, ECO:0000269|PubMed:11568182, ECO:0000269|PubMed:15897867, ECO:0000269|PubMed:16462766, ECO:0000269|PubMed:19767769, ECO:0000269|PubMed:9665135}.; FUNCTION: [Isoform 7]: Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation. {ECO:0000250|UniProtKB:P14404}.FUNCTION: Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi. {ECO:0000269|PubMed:15331763}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMECOMchr3:169098975chr3:167728611ENST00000264674-1171065_111601117.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:169098975chr3:167728611ENST00000392736-1161065_111601052.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:169098975chr3:167728611ENST00000433243-1171065_111601053.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:169098975chr3:167728611ENST00000464456-1151065_111601043.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:169098975chr3:167728611ENST00000468789-1161065_111601052.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:169098975chr3:167728611ENST00000472280-1161065_111601053.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:169098975chr3:167728611ENST00000264674-11778_19001117.0DomainSET
HgeneMECOMchr3:169098975chr3:167728611ENST00000392736-11678_19001052.0DomainSET
HgeneMECOMchr3:169098975chr3:167728611ENST00000433243-11778_19001053.0DomainSET
HgeneMECOMchr3:169098975chr3:167728611ENST00000464456-11578_19001043.0DomainSET
HgeneMECOMchr3:169098975chr3:167728611ENST00000468789-11678_19001052.0DomainSET
HgeneMECOMchr3:169098975chr3:167728611ENST00000472280-11678_19001053.0DomainSET
HgeneMECOMchr3:169098975chr3:167728611ENST00000264674-117609_62201117.0MotifNuclear localization signal
HgeneMECOMchr3:169098975chr3:167728611ENST00000264674-117741_74501117.0MotifCTBP-binding motif 1
HgeneMECOMchr3:169098975chr3:167728611ENST00000264674-117772_77601117.0MotifCTBP-binding motif 2
HgeneMECOMchr3:169098975chr3:167728611ENST00000392736-116609_62201052.0MotifNuclear localization signal
HgeneMECOMchr3:169098975chr3:167728611ENST00000392736-116741_74501052.0MotifCTBP-binding motif 1
HgeneMECOMchr3:169098975chr3:167728611ENST00000392736-116772_77601052.0MotifCTBP-binding motif 2
HgeneMECOMchr3:169098975chr3:167728611ENST00000433243-117609_62201053.0MotifNuclear localization signal
HgeneMECOMchr3:169098975chr3:167728611ENST00000433243-117741_74501053.0MotifCTBP-binding motif 1
HgeneMECOMchr3:169098975chr3:167728611ENST00000433243-117772_77601053.0MotifCTBP-binding motif 2
HgeneMECOMchr3:169098975chr3:167728611ENST00000464456-115609_62201043.0MotifNuclear localization signal
HgeneMECOMchr3:169098975chr3:167728611ENST00000464456-115741_74501043.0MotifCTBP-binding motif 1
HgeneMECOMchr3:169098975chr3:167728611ENST00000464456-115772_77601043.0MotifCTBP-binding motif 2
HgeneMECOMchr3:169098975chr3:167728611ENST00000468789-116609_62201052.0MotifNuclear localization signal
HgeneMECOMchr3:169098975chr3:167728611ENST00000468789-116741_74501052.0MotifCTBP-binding motif 1
HgeneMECOMchr3:169098975chr3:167728611ENST00000468789-116772_77601052.0MotifCTBP-binding motif 2
HgeneMECOMchr3:169098975chr3:167728611ENST00000472280-116609_62201053.0MotifNuclear localization signal
HgeneMECOMchr3:169098975chr3:167728611ENST00000472280-116741_74501053.0MotifCTBP-binding motif 1
HgeneMECOMchr3:169098975chr3:167728611ENST00000472280-116772_77601053.0MotifCTBP-binding motif 2
HgeneMECOMchr3:169098975chr3:167728611ENST00000264674-117209_23601117.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:169098975chr3:167728611ENST00000264674-117263_28501117.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:169098975chr3:167728611ENST00000264674-117291_31301117.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:169098975chr3:167728611ENST00000264674-117319_34201117.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:169098975chr3:167728611ENST00000264674-117348_37001117.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:169098975chr3:167728611ENST00000264674-117376_39801117.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:169098975chr3:167728611ENST00000264674-117405_42701117.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:169098975chr3:167728611ENST00000264674-117912_93401117.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:169098975chr3:167728611ENST00000264674-117940_96301117.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:169098975chr3:167728611ENST00000264674-117969_99101117.0Zinc fingerC2H2-type 10
HgeneMECOMchr3:169098975chr3:167728611ENST00000392736-116209_23601052.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:169098975chr3:167728611ENST00000392736-116263_28501052.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:169098975chr3:167728611ENST00000392736-116291_31301052.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:169098975chr3:167728611ENST00000392736-116319_34201052.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:169098975chr3:167728611ENST00000392736-116348_37001052.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:169098975chr3:167728611ENST00000392736-116376_39801052.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:169098975chr3:167728611ENST00000392736-116405_42701052.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:169098975chr3:167728611ENST00000392736-116912_93401052.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:169098975chr3:167728611ENST00000392736-116940_96301052.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:169098975chr3:167728611ENST00000392736-116969_99101052.0Zinc fingerC2H2-type 10
HgeneMECOMchr3:169098975chr3:167728611ENST00000433243-117209_23601053.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:169098975chr3:167728611ENST00000433243-117263_28501053.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:169098975chr3:167728611ENST00000433243-117291_31301053.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:169098975chr3:167728611ENST00000433243-117319_34201053.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:169098975chr3:167728611ENST00000433243-117348_37001053.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:169098975chr3:167728611ENST00000433243-117376_39801053.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:169098975chr3:167728611ENST00000433243-117405_42701053.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:169098975chr3:167728611ENST00000433243-117912_93401053.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:169098975chr3:167728611ENST00000433243-117940_96301053.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:169098975chr3:167728611ENST00000433243-117969_99101053.0Zinc fingerC2H2-type 10
HgeneMECOMchr3:169098975chr3:167728611ENST00000464456-115209_23601043.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:169098975chr3:167728611ENST00000464456-115263_28501043.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:169098975chr3:167728611ENST00000464456-115291_31301043.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:169098975chr3:167728611ENST00000464456-115319_34201043.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:169098975chr3:167728611ENST00000464456-115348_37001043.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:169098975chr3:167728611ENST00000464456-115376_39801043.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:169098975chr3:167728611ENST00000464456-115405_42701043.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:169098975chr3:167728611ENST00000464456-115912_93401043.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:169098975chr3:167728611ENST00000464456-115940_96301043.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:169098975chr3:167728611ENST00000464456-115969_99101043.0Zinc fingerC2H2-type 10
HgeneMECOMchr3:169098975chr3:167728611ENST00000468789-116209_23601052.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:169098975chr3:167728611ENST00000468789-116263_28501052.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:169098975chr3:167728611ENST00000468789-116291_31301052.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:169098975chr3:167728611ENST00000468789-116319_34201052.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:169098975chr3:167728611ENST00000468789-116348_37001052.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:169098975chr3:167728611ENST00000468789-116376_39801052.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:169098975chr3:167728611ENST00000468789-116405_42701052.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:169098975chr3:167728611ENST00000468789-116912_93401052.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:169098975chr3:167728611ENST00000468789-116940_96301052.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:169098975chr3:167728611ENST00000468789-116969_99101052.0Zinc fingerC2H2-type 10
HgeneMECOMchr3:169098975chr3:167728611ENST00000472280-116209_23601053.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:169098975chr3:167728611ENST00000472280-116263_28501053.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:169098975chr3:167728611ENST00000472280-116291_31301053.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:169098975chr3:167728611ENST00000472280-116319_34201053.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:169098975chr3:167728611ENST00000472280-116348_37001053.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:169098975chr3:167728611ENST00000472280-116376_39801053.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:169098975chr3:167728611ENST00000472280-116405_42701053.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:169098975chr3:167728611ENST00000472280-116912_93401053.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:169098975chr3:167728611ENST00000472280-116940_96301053.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:169098975chr3:167728611ENST00000472280-116969_99101053.0Zinc fingerC2H2-type 10
TgeneGOLIM4chr3:169098975chr3:167728611ENST00000470487131635_244620697.0Coiled coilOntology_term=ECO:0000255
TgeneGOLIM4chr3:169098975chr3:167728611ENST000004704871316311_681620697.0Compositional biasNote=Glu-rich
TgeneGOLIM4chr3:169098975chr3:167728611ENST000004704871316404_513620697.0Compositional biasNote=Gln-rich
TgeneGOLIM4chr3:169098975chr3:167728611ENST000004704871316176_248620697.0RegionNote=Golgi targeting
TgeneGOLIM4chr3:169098975chr3:167728611ENST00000470487131638_107620697.0RegionNote=Golgi targeting
TgeneGOLIM4chr3:169098975chr3:167728611ENST00000470487131680_175620697.0RegionNote=Endosome targeting
TgeneGOLIM4chr3:169098975chr3:167728611ENST0000047048713162_12620697.0Topological domainCytoplasmic
TgeneGOLIM4chr3:169098975chr3:167728611ENST00000470487131634_696620697.0Topological domainLumenal
TgeneGOLIM4chr3:169098975chr3:167728611ENST00000470487131613_33620697.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Gene Sequence for MECOM-GOLIM4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>52497_52497_1_MECOM-GOLIM4_MECOM_chr3_169098975_ENST00000494292_GOLIM4_chr3_167728611_ENST00000309027_length(transcript)=738nt_BP=473nt
AGAGAGAGGGAGGGAGCGAGAGGGAGAGCAAAAGAAGGAAAGGATCCAAGAAAAAAAAGCCCCAACCACACACCAGCGGCTGCAGGACTG
GGCACAGCATGAGATCCAAAGGCAGGGCAAGGAAACTGGCCACAAATAATGAGTGTGTATATGGCAACTACCCTGAAATACCTTTGGAAG
AAATGCCAGATGCAGATGGAGTAGCCAGCACTCCCTCCCTCAATATTCAAGAGCCATGCTCTCCTGCCACATCCAGTGAAGCATTCACTC
CAAAGGAGGGTTCTCCTTACAAAGCCCCCATCTACATCCCTGATGATATCCCCATTCCTGCTGAGTTTGAACTTCGAGAGTCAAATATGC
CTGGGGCAGGACTAGGAATATGGACCAAAAGGAAGATCGAAGTAGGTGAAAAGTTTGGGCCTTATGTGGGAGAGCAGAGGTCAAACCTGA
AAGACCCCAGTTATGGATGGGAGGTTCAGGAAGATTTGACTGAAGAGAAAAAAAGGGAACTGGAGCATAATGCTGAAGAGACCTATGGTG
AAAATGATGAAAATACTGATGATAAAAATAATGATGGAGAAGAGCAAGAAGTTCGAGATGACAACCGCCCCAAAGGCCGAGAGGAACACT
ACGAGGAGGAAGAAGAGGAGGAAGAAGACGGGGCTGCAGTTGCTGAGAAATCACATCGAAGAGCTGAAATGTAGCGGCACCCAATTTCTA

>52497_52497_1_MECOM-GOLIM4_MECOM_chr3_169098975_ENST00000494292_GOLIM4_chr3_167728611_ENST00000309027_length(amino acids)=201AA_BP=125
MRSKGRARKLATNNECVYGNYPEIPLEEMPDADGVASTPSLNIQEPCSPATSSEAFTPKEGSPYKAPIYIPDDIPIPAEFELRESNMPGA
GLGIWTKRKIEVGEKFGPYVGEQRSNLKDPSYGWEVQEDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDDNRPKGREEHYEE

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>52497_52497_2_MECOM-GOLIM4_MECOM_chr3_169098975_ENST00000494292_GOLIM4_chr3_167728611_ENST00000470487_length(transcript)=2296nt_BP=473nt
AGAGAGAGGGAGGGAGCGAGAGGGAGAGCAAAAGAAGGAAAGGATCCAAGAAAAAAAAGCCCCAACCACACACCAGCGGCTGCAGGACTG
GGCACAGCATGAGATCCAAAGGCAGGGCAAGGAAACTGGCCACAAATAATGAGTGTGTATATGGCAACTACCCTGAAATACCTTTGGAAG
AAATGCCAGATGCAGATGGAGTAGCCAGCACTCCCTCCCTCAATATTCAAGAGCCATGCTCTCCTGCCACATCCAGTGAAGCATTCACTC
CAAAGGAGGGTTCTCCTTACAAAGCCCCCATCTACATCCCTGATGATATCCCCATTCCTGCTGAGTTTGAACTTCGAGAGTCAAATATGC
CTGGGGCAGGACTAGGAATATGGACCAAAAGGAAGATCGAAGTAGGTGAAAAGTTTGGGCCTTATGTGGGAGAGCAGAGGTCAAACCTGA
AAGACCCCAGTTATGGATGGGAGGTTCAGGAAGATTTGACTGAAGAGAAAAAAAGGGAACTGGAGCATAATGCTGAAGAGACCTATGGTG
AAAATGATGAAAATACTGATGATAAAAATAATGATGGAGAAGAGCAAGAAGTTCGAGATGACAACCGCCCCAAAGGCCGAGAGGAACACT
ACGAGGAGGAAGAAGAGGAGGAAGAAGACGGGGCTGCAGTTGCTGAGAAATCACATCGAAGAGCTGAAATGTAGCGGCACCCAATTTCTA
GACAACGCTCAGCCAACGGATTCTTTTCAAGCTGCTCAAACATAAATCTGCCTACTGAACTCTAGGATATTTAATTACAAAAATTAAGAA
CTTAGACTTTTTTAAAACTTTTGTATTAGAAATGCGCATACATTTATATGAATATATTTTGATAACGTAGGTCTAGAGCTTCTTTTATAT
TCAAGCTAAACATGAAAAAGAAGAAAAACAATAAAGTAAACCTGAGCCCCCACGTCCCAATTTTTTTAATAGATTATGTGATGTTGGAAA
GCTCATTGATTTTGTATATGTTTCAGCGTGTTACCTTTCTGGCTTCCAGTTCCCAGGTGTTCTTTGTTTGCCTTTGATAAAATACAGGAT
TTAAGAACAGAGAGTACTGCAAAATGCCATGCAGACTTTAAAGAGAATGGCCTGTTTACTAATTGCTGCCCTTCTGATGTCTTTATGTAT
AGCTCTGATAGAATTTTCACCAGTCTATGTATCTCTGGAGTGAGATCTATGTACAAAGTGACATACAATTGGAAATCCATTTTTGTTGTA
AAGACATTGTTTTTCAGACTTTTCAGATCAATTAGAAAAATGTCATTGCTTTAAAATCATAGCTGTTCTGTTTAAGAGGAATTGAATTTA
AAAATGAGAGAGTATTAAAACTCATGTGGCAGTATCCTGGTCTTAATCAGGTATTGCAGTGTTCAAACAAGGTATGGACACATCAACATA
TTCACCTTTTGGAAGGACTAGTGACTTGGTTAAAAACTAATGAGTGTTTGCGTGTGGTGTTTCTATGCGAGCACCCATTCTCAATTTTTT
TTTTTTTTTTTTGTTTGAAGCCATTGATTGATATTCTTGTTTCAGTGTCTGGTTCCCTATAAGTAATATATATTTCCTCTTTAAGCTCTG
TGCCTCAATATGCAATCACTTTGATAATAAGTATAAATATGAAGACATACCAAACTGCAAATAGGATTATTTTTCAAAACTATATGGTGA
AACATATGGTGATATGATAGACTTATGGTTTTTCTGTTTGCTGGGATTGGGTCTGCTTTTTGCCTATGTGTAAGGCATTTTAATCATTGT
GAATATAATAGATTCCTTAAAATAAGAAAATTAAAAATCAGAAACTTCCCTTGGAGTAGAGACATTTCAGTTGCAAGCATAAAGATTTTT
AAATATATAACACTAGGTTATATAATTCATATATGTGTGGTTTTGTATTAATAATCAAATTAATAAAAACATTTCATTTTCTACCATTGT
ATGAACGTAATTTTATTTTTTAATAACCACACTCATAGATGGTTTTGATTGTTCCAGTTGAGTGATTGTGTATGTACGCATAGGAATGTT
TTGTTCAGTTGTACTTTGTATTTCCAATAATCAGAAATCTTACCTTTATGTATAAAAACCCATTATGTAATGTAAAATGTATAATATTGT
ACATAATATTCAGAATACAATTATTTTGGTAAATTAGCTTGTATTTTTAATGTCCCAGTTGCAGTATTTAATTATTTGAACCATACTGAA

>52497_52497_2_MECOM-GOLIM4_MECOM_chr3_169098975_ENST00000494292_GOLIM4_chr3_167728611_ENST00000470487_length(amino acids)=201AA_BP=125
MRSKGRARKLATNNECVYGNYPEIPLEEMPDADGVASTPSLNIQEPCSPATSSEAFTPKEGSPYKAPIYIPDDIPIPAEFELRESNMPGA
GLGIWTKRKIEVGEKFGPYVGEQRSNLKDPSYGWEVQEDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDDNRPKGREEHYEE

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Fusion Gene PPI Analysis for MECOM-GOLIM4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMECOMchr3:169098975chr3:167728611ENST00000264674-117189_44001117.0MAPK9%2C SMAD3 and probably SUV39H1
HgeneMECOMchr3:169098975chr3:167728611ENST00000392736-116189_44001052.0MAPK9%2C SMAD3 and probably SUV39H1
HgeneMECOMchr3:169098975chr3:167728611ENST00000433243-117189_44001053.0MAPK9%2C SMAD3 and probably SUV39H1
HgeneMECOMchr3:169098975chr3:167728611ENST00000464456-115189_44001043.0MAPK9%2C SMAD3 and probably SUV39H1
HgeneMECOMchr3:169098975chr3:167728611ENST00000468789-116189_44001052.0MAPK9%2C SMAD3 and probably SUV39H1
HgeneMECOMchr3:169098975chr3:167728611ENST00000472280-116189_44001053.0MAPK9%2C SMAD3 and probably SUV39H1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MECOM-GOLIM4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MECOM-GOLIM4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource