FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:MECOM-NCEH1 (FusionGDB2 ID:52508)

Fusion Gene Summary for MECOM-NCEH1

check button Fusion gene summary
Fusion gene informationFusion gene name: MECOM-NCEH1
Fusion gene ID: 52508
HgeneTgene
Gene symbol

MECOM

NCEH1

Gene ID

2122

57552

Gene nameMDS1 and EVI1 complex locusneutral cholesterol ester hydrolase 1
SynonymsAML1-EVI-1|EVI1|KMT8E|MDS1|MDS1-EVI1|PRDM3|RUSAT2AADACL1|NCEH
Cytomap

3q26.2

3q26.31

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase MECOMAML1-EVI-1 fusion proteinMDS1 and EVI1 complex locus protein EVI1MDS1 and EVI1 complex locus protein MDS1PR domain 3ecotropic virus integration site 1 protein homologmyelodysplasia syndrome-associated protein neutral cholesterol ester hydrolase 1acetylalkylglycerol acetylhydrolasealkylacetylglycerol acetylhydrolasearylacetamide deacetylase-like 1
Modification date2020031320200313
UniProtAcc

Q03112

Q6PIU2

Ensembl transtripts involved in fusion geneENST00000494292, ENST00000485957, 
ENST00000264674, ENST00000392736, 
ENST00000433243, ENST00000460814, 
ENST00000464456, ENST00000468789, 
ENST00000472280, 		ENST00000543711, 
ENST00000273512, ENST00000475381, 
ENST00000538775, 
Fusion gene scores* DoF score33 X 21 X 11=762312 X 11 X 9=1188
# samples 4317
** MAII scorelog2(43/7623*10)=-4.14795031118505
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1188*10)=-2.80492818466306
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MECOM [Title/Abstract] AND NCEH1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMECOM(169381124)-NCEH1(172363482), # samples:3
Anticipated loss of major functional domain due to fusion event.MECOM-NCEH1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
MECOM-NCEH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
MECOM-NCEH1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMECOM

GO:0045892

negative regulation of transcription, DNA-templated

10856240|11568182

HgeneMECOM

GO:0045893

positive regulation of transcription, DNA-templated

11568182|19767769

HgeneMECOM

GO:0051726

regulation of cell cycle

11568182


check buttonFusion gene breakpoints across MECOM (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NCEH1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCSTCGA-N9-A4Q8-01AMECOMchr3

169381124

-NCEH1chr3

172363482

-
ChimerDB4UCSTCGA-N9-A4Q8MECOMchr3

169381124

-NCEH1chr3

172363482

-
ChimerDB4UCSTCGA-N9-A4Q8MECOMchr3

169381124

-NCEH1chr3

172365904

-


Top

Fusion Gene ORF analysis for MECOM-NCEH1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000494292ENST00000543711MECOMchr3

169381124

-NCEH1chr3

172363482

-
5CDS-intronENST00000494292ENST00000543711MECOMchr3

169381124

-NCEH1chr3

172365904

-
5UTR-3CDSENST00000485957ENST00000273512MECOMchr3

169381124

-NCEH1chr3

172363482

-
5UTR-3CDSENST00000485957ENST00000273512MECOMchr3

169381124

-NCEH1chr3

172365904

-
5UTR-3CDSENST00000485957ENST00000475381MECOMchr3

169381124

-NCEH1chr3

172363482

-
5UTR-3CDSENST00000485957ENST00000475381MECOMchr3

169381124

-NCEH1chr3

172365904

-
5UTR-3CDSENST00000485957ENST00000538775MECOMchr3

169381124

-NCEH1chr3

172363482

-
5UTR-3CDSENST00000485957ENST00000538775MECOMchr3

169381124

-NCEH1chr3

172365904

-
5UTR-5UTRENST00000485957ENST00000543711MECOMchr3

169381124

-NCEH1chr3

172363482

-
5UTR-intronENST00000485957ENST00000543711MECOMchr3

169381124

-NCEH1chr3

172365904

-
Frame-shiftENST00000494292ENST00000273512MECOMchr3

169381124

-NCEH1chr3

172363482

-
Frame-shiftENST00000494292ENST00000475381MECOMchr3

169381124

-NCEH1chr3

172363482

-
Frame-shiftENST00000494292ENST00000538775MECOMchr3

169381124

-NCEH1chr3

172363482

-
In-frameENST00000494292ENST00000273512MECOMchr3

169381124

-NCEH1chr3

172365904

-
In-frameENST00000494292ENST00000475381MECOMchr3

169381124

-NCEH1chr3

172365904

-
In-frameENST00000494292ENST00000538775MECOMchr3

169381124

-NCEH1chr3

172365904

-
intron-3CDSENST00000264674ENST00000273512MECOMchr3

169381124

-NCEH1chr3

172363482

-
intron-3CDSENST00000264674ENST00000273512MECOMchr3

169381124

-NCEH1chr3

172365904

-
intron-3CDSENST00000264674ENST00000475381MECOMchr3

169381124

-NCEH1chr3

172363482

-
intron-3CDSENST00000264674ENST00000475381MECOMchr3

169381124

-NCEH1chr3

172365904

-
intron-3CDSENST00000264674ENST00000538775MECOMchr3

169381124

-NCEH1chr3

172363482

-
intron-3CDSENST00000264674ENST00000538775MECOMchr3

169381124

-NCEH1chr3

172365904

-
intron-3CDSENST00000392736ENST00000273512MECOMchr3

169381124

-NCEH1chr3

172363482

-
intron-3CDSENST00000392736ENST00000273512MECOMchr3

169381124

-NCEH1chr3

172365904

-
intron-3CDSENST00000392736ENST00000475381MECOMchr3

169381124

-NCEH1chr3

172363482

-
intron-3CDSENST00000392736ENST00000475381MECOMchr3

169381124

-NCEH1chr3

172365904

-
intron-3CDSENST00000392736ENST00000538775MECOMchr3

169381124

-NCEH1chr3

172363482

-
intron-3CDSENST00000392736ENST00000538775MECOMchr3

169381124

-NCEH1chr3

172365904

-
intron-3CDSENST00000433243ENST00000273512MECOMchr3

169381124

-NCEH1chr3

172363482

-
intron-3CDSENST00000433243ENST00000273512MECOMchr3

169381124

-NCEH1chr3

172365904

-
intron-3CDSENST00000433243ENST00000475381MECOMchr3

169381124

-NCEH1chr3

172363482

-
intron-3CDSENST00000433243ENST00000475381MECOMchr3

169381124

-NCEH1chr3

172365904

-
intron-3CDSENST00000433243ENST00000538775MECOMchr3

169381124

-NCEH1chr3

172363482

-
intron-3CDSENST00000433243ENST00000538775MECOMchr3

169381124

-NCEH1chr3

172365904

-
intron-3CDSENST00000460814ENST00000273512MECOMchr3

169381124

-NCEH1chr3

172363482

-
intron-3CDSENST00000460814ENST00000273512MECOMchr3

169381124

-NCEH1chr3

172365904

-
intron-3CDSENST00000460814ENST00000475381MECOMchr3

169381124

-NCEH1chr3

172363482

-
intron-3CDSENST00000460814ENST00000475381MECOMchr3

169381124

-NCEH1chr3

172365904

-
intron-3CDSENST00000460814ENST00000538775MECOMchr3

169381124

-NCEH1chr3

172363482

-
intron-3CDSENST00000460814ENST00000538775MECOMchr3

169381124

-NCEH1chr3

172365904

-
intron-3CDSENST00000464456ENST00000273512MECOMchr3

169381124

-NCEH1chr3

172363482

-
intron-3CDSENST00000464456ENST00000273512MECOMchr3

169381124

-NCEH1chr3

172365904

-
intron-3CDSENST00000464456ENST00000475381MECOMchr3

169381124

-NCEH1chr3

172363482

-
intron-3CDSENST00000464456ENST00000475381MECOMchr3

169381124

-NCEH1chr3

172365904

-
intron-3CDSENST00000464456ENST00000538775MECOMchr3

169381124

-NCEH1chr3

172363482

-
intron-3CDSENST00000464456ENST00000538775MECOMchr3

169381124

-NCEH1chr3

172365904

-
intron-3CDSENST00000468789ENST00000273512MECOMchr3

169381124

-NCEH1chr3

172363482

-
intron-3CDSENST00000468789ENST00000273512MECOMchr3

169381124

-NCEH1chr3

172365904

-
intron-3CDSENST00000468789ENST00000475381MECOMchr3

169381124

-NCEH1chr3

172363482

-
intron-3CDSENST00000468789ENST00000475381MECOMchr3

169381124

-NCEH1chr3

172365904

-
intron-3CDSENST00000468789ENST00000538775MECOMchr3

169381124

-NCEH1chr3

172363482

-
intron-3CDSENST00000468789ENST00000538775MECOMchr3

169381124

-NCEH1chr3

172365904

-
intron-3CDSENST00000472280ENST00000273512MECOMchr3

169381124

-NCEH1chr3

172363482

-
intron-3CDSENST00000472280ENST00000273512MECOMchr3

169381124

-NCEH1chr3

172365904

-
intron-3CDSENST00000472280ENST00000475381MECOMchr3

169381124

-NCEH1chr3

172363482

-
intron-3CDSENST00000472280ENST00000475381MECOMchr3

169381124

-NCEH1chr3

172365904

-
intron-3CDSENST00000472280ENST00000538775MECOMchr3

169381124

-NCEH1chr3

172363482

-
intron-3CDSENST00000472280ENST00000538775MECOMchr3

169381124

-NCEH1chr3

172365904

-
intron-5UTRENST00000264674ENST00000543711MECOMchr3

169381124

-NCEH1chr3

172363482

-
intron-5UTRENST00000392736ENST00000543711MECOMchr3

169381124

-NCEH1chr3

172363482

-
intron-5UTRENST00000433243ENST00000543711MECOMchr3

169381124

-NCEH1chr3

172363482

-
intron-5UTRENST00000460814ENST00000543711MECOMchr3

169381124

-NCEH1chr3

172363482

-
intron-5UTRENST00000464456ENST00000543711MECOMchr3

169381124

-NCEH1chr3

172363482

-
intron-5UTRENST00000468789ENST00000543711MECOMchr3

169381124

-NCEH1chr3

172363482

-
intron-5UTRENST00000472280ENST00000543711MECOMchr3

169381124

-NCEH1chr3

172363482

-
intron-intronENST00000264674ENST00000543711MECOMchr3

169381124

-NCEH1chr3

172365904

-
intron-intronENST00000392736ENST00000543711MECOMchr3

169381124

-NCEH1chr3

172365904

-
intron-intronENST00000433243ENST00000543711MECOMchr3

169381124

-NCEH1chr3

172365904

-
intron-intronENST00000460814ENST00000543711MECOMchr3

169381124

-NCEH1chr3

172365904

-
intron-intronENST00000464456ENST00000543711MECOMchr3

169381124

-NCEH1chr3

172365904

-
intron-intronENST00000468789ENST00000543711MECOMchr3

169381124

-NCEH1chr3

172365904

-
intron-intronENST00000472280ENST00000543711MECOMchr3

169381124

-NCEH1chr3

172365904

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000494292MECOMchr3169381124-ENST00000475381NCEH1chr3172365904-44501351411223360
ENST00000494292MECOMchr3169381124-ENST00000273512NCEH1chr3172365904-40541351411223360
ENST00000494292MECOMchr3169381124-ENST00000538775NCEH1chr3172365904-40781351411247368

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000494292ENST00000475381MECOMchr3169381124-NCEH1chr3172365904-0.0002400120.99976
ENST00000494292ENST00000273512MECOMchr3169381124-NCEH1chr3172365904-0.0002161250.99978393
ENST00000494292ENST00000538775MECOMchr3169381124-NCEH1chr3172365904-0.0002180060.999782

Top

Fusion Genomic Features for MECOM-NCEH1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for MECOM-NCEH1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:169381124/chr3:172363482)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MECOM

Q03112

NCEH1

Q6PIU2

FUNCTION: [Isoform 1]: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. {ECO:0000269|PubMed:10856240, ECO:0000269|PubMed:11568182, ECO:0000269|PubMed:15897867, ECO:0000269|PubMed:16462766, ECO:0000269|PubMed:19767769, ECO:0000269|PubMed:9665135}.; FUNCTION: [Isoform 7]: Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation. {ECO:0000250|UniProtKB:P14404}.FUNCTION: Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (PubMed:17052608). May be responsible for cholesterol ester hydrolysis in macrophages (By similarity). Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds (By similarity). May contribute to cancer pathogenesis by promoting tumor cell migration (PubMed:17052608). {ECO:0000250|UniProtKB:Q8BLF1, ECO:0000269|PubMed:17052608}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNCEH1chr3:169381124chr3:172365904ENST0000047538105113_11546409.0MotifInvolved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole
TgeneNCEH1chr3:169381124chr3:172365904ENST0000054371104113_1150276.0MotifInvolved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole
TgeneNCEH1chr3:169381124chr3:172365904ENST00000543711041_40276.0Topological domainCytoplasmic
TgeneNCEH1chr3:169381124chr3:172365904ENST000005437110426_4080276.0Topological domainLumenal
TgeneNCEH1chr3:169381124chr3:172365904ENST00000543711045_250276.0TransmembraneHelical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMECOMchr3:169381124chr3:172365904ENST00000264674-1171065_111601117.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:169381124chr3:172365904ENST00000392736-1161065_111601052.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:169381124chr3:172365904ENST00000433243-1171065_111601053.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:169381124chr3:172365904ENST00000464456-1151065_111601043.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:169381124chr3:172365904ENST00000468789-1161065_111601052.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:169381124chr3:172365904ENST00000472280-1161065_111601053.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:169381124chr3:172365904ENST00000264674-11778_19001117.0DomainSET
HgeneMECOMchr3:169381124chr3:172365904ENST00000392736-11678_19001052.0DomainSET
HgeneMECOMchr3:169381124chr3:172365904ENST00000433243-11778_19001053.0DomainSET
HgeneMECOMchr3:169381124chr3:172365904ENST00000464456-11578_19001043.0DomainSET
HgeneMECOMchr3:169381124chr3:172365904ENST00000468789-11678_19001052.0DomainSET
HgeneMECOMchr3:169381124chr3:172365904ENST00000472280-11678_19001053.0DomainSET
HgeneMECOMchr3:169381124chr3:172365904ENST00000264674-117609_62201117.0MotifNuclear localization signal
HgeneMECOMchr3:169381124chr3:172365904ENST00000264674-117741_74501117.0MotifCTBP-binding motif 1
HgeneMECOMchr3:169381124chr3:172365904ENST00000264674-117772_77601117.0MotifCTBP-binding motif 2
HgeneMECOMchr3:169381124chr3:172365904ENST00000392736-116609_62201052.0MotifNuclear localization signal
HgeneMECOMchr3:169381124chr3:172365904ENST00000392736-116741_74501052.0MotifCTBP-binding motif 1
HgeneMECOMchr3:169381124chr3:172365904ENST00000392736-116772_77601052.0MotifCTBP-binding motif 2
HgeneMECOMchr3:169381124chr3:172365904ENST00000433243-117609_62201053.0MotifNuclear localization signal
HgeneMECOMchr3:169381124chr3:172365904ENST00000433243-117741_74501053.0MotifCTBP-binding motif 1
HgeneMECOMchr3:169381124chr3:172365904ENST00000433243-117772_77601053.0MotifCTBP-binding motif 2
HgeneMECOMchr3:169381124chr3:172365904ENST00000464456-115609_62201043.0MotifNuclear localization signal
HgeneMECOMchr3:169381124chr3:172365904ENST00000464456-115741_74501043.0MotifCTBP-binding motif 1
HgeneMECOMchr3:169381124chr3:172365904ENST00000464456-115772_77601043.0MotifCTBP-binding motif 2
HgeneMECOMchr3:169381124chr3:172365904ENST00000468789-116609_62201052.0MotifNuclear localization signal
HgeneMECOMchr3:169381124chr3:172365904ENST00000468789-116741_74501052.0MotifCTBP-binding motif 1
HgeneMECOMchr3:169381124chr3:172365904ENST00000468789-116772_77601052.0MotifCTBP-binding motif 2
HgeneMECOMchr3:169381124chr3:172365904ENST00000472280-116609_62201053.0MotifNuclear localization signal
HgeneMECOMchr3:169381124chr3:172365904ENST00000472280-116741_74501053.0MotifCTBP-binding motif 1
HgeneMECOMchr3:169381124chr3:172365904ENST00000472280-116772_77601053.0MotifCTBP-binding motif 2
HgeneMECOMchr3:169381124chr3:172365904ENST00000264674-117209_23601117.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:169381124chr3:172365904ENST00000264674-117263_28501117.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:169381124chr3:172365904ENST00000264674-117291_31301117.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:169381124chr3:172365904ENST00000264674-117319_34201117.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:169381124chr3:172365904ENST00000264674-117348_37001117.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:169381124chr3:172365904ENST00000264674-117376_39801117.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:169381124chr3:172365904ENST00000264674-117405_42701117.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:169381124chr3:172365904ENST00000264674-117912_93401117.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:169381124chr3:172365904ENST00000264674-117940_96301117.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:169381124chr3:172365904ENST00000264674-117969_99101117.0Zinc fingerC2H2-type 10
HgeneMECOMchr3:169381124chr3:172365904ENST00000392736-116209_23601052.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:169381124chr3:172365904ENST00000392736-116263_28501052.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:169381124chr3:172365904ENST00000392736-116291_31301052.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:169381124chr3:172365904ENST00000392736-116319_34201052.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:169381124chr3:172365904ENST00000392736-116348_37001052.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:169381124chr3:172365904ENST00000392736-116376_39801052.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:169381124chr3:172365904ENST00000392736-116405_42701052.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:169381124chr3:172365904ENST00000392736-116912_93401052.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:169381124chr3:172365904ENST00000392736-116940_96301052.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:169381124chr3:172365904ENST00000392736-116969_99101052.0Zinc fingerC2H2-type 10
HgeneMECOMchr3:169381124chr3:172365904ENST00000433243-117209_23601053.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:169381124chr3:172365904ENST00000433243-117263_28501053.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:169381124chr3:172365904ENST00000433243-117291_31301053.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:169381124chr3:172365904ENST00000433243-117319_34201053.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:169381124chr3:172365904ENST00000433243-117348_37001053.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:169381124chr3:172365904ENST00000433243-117376_39801053.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:169381124chr3:172365904ENST00000433243-117405_42701053.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:169381124chr3:172365904ENST00000433243-117912_93401053.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:169381124chr3:172365904ENST00000433243-117940_96301053.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:169381124chr3:172365904ENST00000433243-117969_99101053.0Zinc fingerC2H2-type 10
HgeneMECOMchr3:169381124chr3:172365904ENST00000464456-115209_23601043.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:169381124chr3:172365904ENST00000464456-115263_28501043.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:169381124chr3:172365904ENST00000464456-115291_31301043.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:169381124chr3:172365904ENST00000464456-115319_34201043.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:169381124chr3:172365904ENST00000464456-115348_37001043.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:169381124chr3:172365904ENST00000464456-115376_39801043.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:169381124chr3:172365904ENST00000464456-115405_42701043.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:169381124chr3:172365904ENST00000464456-115912_93401043.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:169381124chr3:172365904ENST00000464456-115940_96301043.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:169381124chr3:172365904ENST00000464456-115969_99101043.0Zinc fingerC2H2-type 10
HgeneMECOMchr3:169381124chr3:172365904ENST00000468789-116209_23601052.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:169381124chr3:172365904ENST00000468789-116263_28501052.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:169381124chr3:172365904ENST00000468789-116291_31301052.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:169381124chr3:172365904ENST00000468789-116319_34201052.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:169381124chr3:172365904ENST00000468789-116348_37001052.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:169381124chr3:172365904ENST00000468789-116376_39801052.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:169381124chr3:172365904ENST00000468789-116405_42701052.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:169381124chr3:172365904ENST00000468789-116912_93401052.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:169381124chr3:172365904ENST00000468789-116940_96301052.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:169381124chr3:172365904ENST00000468789-116969_99101052.0Zinc fingerC2H2-type 10
HgeneMECOMchr3:169381124chr3:172365904ENST00000472280-116209_23601053.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:169381124chr3:172365904ENST00000472280-116263_28501053.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:169381124chr3:172365904ENST00000472280-116291_31301053.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:169381124chr3:172365904ENST00000472280-116319_34201053.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:169381124chr3:172365904ENST00000472280-116348_37001053.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:169381124chr3:172365904ENST00000472280-116376_39801053.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:169381124chr3:172365904ENST00000472280-116405_42701053.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:169381124chr3:172365904ENST00000472280-116912_93401053.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:169381124chr3:172365904ENST00000472280-116940_96301053.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:169381124chr3:172365904ENST00000472280-116969_99101053.0Zinc fingerC2H2-type 10
TgeneNCEH1chr3:169381124chr3:172365904ENST00000475381051_446409.0Topological domainCytoplasmic
TgeneNCEH1chr3:169381124chr3:172365904ENST000004753810526_40846409.0Topological domainLumenal
TgeneNCEH1chr3:169381124chr3:172365904ENST00000475381055_2546409.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


Top

Fusion Gene Sequence for MECOM-NCEH1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>52508_52508_1_MECOM-NCEH1_MECOM_chr3_169381124_ENST00000494292_NCEH1_chr3_172365904_ENST00000273512_length(transcript)=4054nt_BP=135nt
AGAGAGAGGGAGGGAGCGAGAGGGAGAGCAAAAGAAGGAAAGGATCCAAGAAAAAAAAGCCCCAACCACACACCAGCGGCTGCAGGACTG
GGCACAGCATGAGATCCAAAGGCAGGGCAAGGAAACTGGCCACAAAGTAACCTGATCCACTACCTGGGACTGAGCCATCACCTGCTGGCA
CTGAATTTTATCATTGTTTCTTTTGGCAAAAAAAGCGCGTGGTCTTCTGCCCAAGTGAAGGTGACCGACACAGACTTTGATGGTGTGGAA
GTCAGAGTGTTTGAAGGCCCTCCGAAGCCCGAAGAGCCACTGAAACGCAGCGTCGTTTATATCCACGGAGGAGGCTGGGCCTTGGCAAGT
GCAAAAATCAGGTATTATGATGAGCTGTGTACAGCAATGGCTGAGGAATTGAATGCTGTCATTGTTTCCATTGAATACAGGCTAGTTCCA
AAGGTTTATTTTCCTGAGCAAATTCATGATGTTGTACGGGCCACAAAGTATTTCCTGAAGCCAGAAGTCTTACAGAAGTATATGGTTGAT
CCAGGCAGAATTTGCATTTCTGGTGACAGTGCTGGTGGAAATCTGGCTGCTGCCCTTGGACAACAGTTTACTCAAGATGCCAGCCTAAAA
AATAAGCTCAAACTACAAGCTTTAATTTATCCAGTTCTTCAAGCTTTAGATTTTAACACACCATCTTATCAGCAAAATGTGAACACCCCA
ATCCTGCCCCGCTATGTCATGGTGAAGTATTGGGTGGACTACTTCAAAGGCAACTATGACTTTGTGCAGGCAATGATCGTTAACAATCAC
ACTTCACTTGATGTGGAAGAGGCTGCTGCTGTCAGGGCCCGTCTAAACTGGACATCCCTCTTGCCTGCATCCTTCACAAAGAACTACAAG
CCTGTTGTACAGACCACAGGCAATGCCAGGATTGTCCAGGAGCTTCCTCAGTTGCTGGATGCCCGCTCCGCCCCACTCATTGCAGACCAG
GCAGTGCTGCAGCTCCTCCCAAAGACCTACATTCTGACGTGTGAGCATGATGTCCTCAGAGACGATGGCATCATGTATGCCAAGCGTTTG
GAGAGTGCCGGTGTGGAGGTGACCCTGGATCACTTTGAGGATGGCTTTCACGGATGTATGATTTTCACTAGCTGGCCCACCAACTTCTCA
GTGGGAATCCGGACTAGGAATAGTTACATCAAGTGGCTAGATCAAAACCTGTAAAGGAGCAAAACTTCCAGAAGCCTCGAGCCCCTCTTG
ACCTCCTACACCTGCTTTGGAAAGACATGCACTTTTTAGTTGACTAATTCTTCCTCCCATTCCCCTCTACTTGCGAGTTATGGAATTTCT
ATTCCATAACTGAAGTCTTTATGATAACCTAATTTTTAAAAATGAATTTGACTAACTTAAGTGCAAAACATGTAAATTTGGTTCCCAGAG
TGGGCCAATCTCTCTGTTCTTGTTATCTTAGCCAACTATACTGATACCTACAGCTACAGAAAGCAGGACTAGGAACTGGAAATAACTTTG
GGTCCTGCCTTCATTAGGACGTTCTTTTTAGAAGCAGTTCTTCCAGCTCTGGATCATAGAGTGACCTTTAATAAGTTAAAAAAACGAGGA
CTCCTTAATTCTGCTAGAGTTAACCTTGAGTTCAGAGCAGTATTAAATGCGTGCACTTTCAGGTCAGTACTGGGGACCAAGTACCCTCTG
GTCTTTTGTGAATGGATGGTTTTGTTTCCTATGGGAATTTTGGCAAAGGTTTTCTGGAAAGAACAAGTTTCTCAAAGGACTTTCTTCCTC
TAGAATGTTCATTTTATGAGATCGCTATCTGTAAGTCCAGTTGGATTACAGGAATACTTGAAAGTTACTTTCTACCACTATTAGAAAATA
TGAAGTCGCATGCACTGGATATCTATATATCATTAGGTTTTTGTTGTGTTTTTGGTTATGCTGTCCCCCTTCTCCTTGGGGAGATATTTG
GGAGCAAACTTATTTAGATTTAGAGTAAACTTTTCATTATAGAGCAAGTAAAAACAGACAAATGAAACAACCTAGTGTTTCACATAAAAA
TACTTCTGACATAAAGTACCAAGAGCAGTGTGAATATACTTGGCATAGTCAAAAAAGAAAATACATTTAATATTAGTTCAAAATTGTTAA
AAATACCTTTAGAAGGTCTAGTCTATTATTGAAAACTCAATTTTTTCACTTATATGGCTTTAAAATGGAGCTATTTTGCTACAATATAAT
GTATTGTTTATTTTTTTAAGTTATTTAATGTTAATATACATAGCTAGACTTAAGGTTTTTCAGAAAGATGTCCATAATAAATATTAAAAA
CAATGGTATTTTTTAAAAAACTGCCTTAGGGTTTTAAAACCTTCCCTACAGTTATAACCACGTGTAATTTTGTGGAAATGATATAACAGC
TATTAATACTACTATAACATAGGCATAAATATTTTCGTGTTTATATGCATATACAAGTTAAAATAATTAGAAACTATGACTGCGCCTAGT
AAAGTCATCTAGGTTTATAGTTCAGTAGCTTAGGCAAGGCACACACTGCTCATCTCCGCTTTTTAGGGTCAGAGGAACACAAGCTCATGT
TCTGAGTGAAGGGCGTACACTGGCACCTGGTGTTGCCTAGATCCCCCATCTCCTCCTTCCAGCCAGGTCTGGAAGTTTCAACAGCCCAAG
CTTAACTTCATGTAAAGTCTTCACTGCCAGTGGGAACATCTTTGACACAACAAGACACTCCAATTGTGATTTGAGTTGAGGATCTCTGCC
TGCCTTCCTGCCGTCCTTCCTTCTTCCCCGATCCATGCTACTTTTAGGGGCTGCGGAGAGCAGCAGCAGAGCTGAGTAATGATACAGGGC
ACCACGGAGAGAAAGTAGAACCATTTCACTCCTGGGAAGATGGGGTATTTCCCACTTCCAGCAACGAAATAACAAATGAAAAGTTGCATA
CTTATTGATGTATTGTATGAGCCAGTAGCATTTTATGTACAAAACAGAAGTCAATGCAACAGTATGTATGTGTGCCTGTGTGTGTATAAA
AATAACCATTGAAGCTAACTTGCTAATGTACTTAGGCAAGCCACTTCCCATCTCTGGGCCTCGTCTTTCCTCCCTCTAAAATCAAAGAGC
TGAATTATGTGATCCTTGAGGTCTCTTCCACTTATAATACCAACTGTCTTGTCAGACTGGCAAATTATATTGGCCTCTCCTTATGTGGTG
GTTTTTTTGGTAGGTCATAGTTCCTTATACACAGACACCTGCATCATCGAAGGTCTTTTTTTCCTAAAAAAAAAAAATGGGATTTTAGTT
CTTATTCTGTGATAACTATCCTCCTCATATAATACTATTCTTTTTGACACCATTTGAAGGAACCAATATTTGGACCTTATTTTGAGGTTG
TCTGTCTCGAAGAAAAAGAAAATAAAATGTATAGGCAGGGTTCCTTCAATTGGCATTTTCCCCAGAATTGTGAGCCAAAGCCTATAGTAA
TTGCAGACAGCAAATGATTCCGGATCTCTAAAAGGCTCTCTCAGATGAAAAGGGAGTAAAGGAAAAAAGAGGTCAACCACTGTTTCTGAT
AATGTACTTGAGTTTCATTGTTCTTTTAGTTTGTATTCTTATAAAAAATGTTTACACTCTGCAGATTGATTTTTTTTTTTTAGTACTGTG
GCTTTCTTTTCCTATTTTATGAAAAAAATGATAATCTTTTTGTAAAATTGTCTGTGAAATATAAACATTAATATATAAAGAAAAACCTTG
AAGTGCTGTATAGTGAAGTATAAATTAATGTTTTATTGATTTGTGAAGAATTTAAGACTATTATATAATTATCTTGGTGGATCTATTTTA
TGCATGACCTTTTAACCTTTGACTTTGCTTATTTCCCACTACGAAGGGGAAGGTAGATTTTATGAATGATTTTAATAGCAAATATATTTT
ATAAAGTGAAAATCCAGTGTGGAGGTAGCAAAGCATCTATCTATTCTGAATCATGTTTGGAAATAAAATTGCTCCATCTGGGAATGTGCT

>52508_52508_1_MECOM-NCEH1_MECOM_chr3_169381124_ENST00000494292_NCEH1_chr3_172365904_ENST00000273512_length(amino acids)=360AA_BP=
MIHYLGLSHHLLALNFIIVSFGKKSAWSSAQVKVTDTDFDGVEVRVFEGPPKPEEPLKRSVVYIHGGGWALASAKIRYYDELCTAMAEEL
NAVIVSIEYRLVPKVYFPEQIHDVVRATKYFLKPEVLQKYMVDPGRICISGDSAGGNLAAALGQQFTQDASLKNKLKLQALIYPVLQALD
FNTPSYQQNVNTPILPRYVMVKYWVDYFKGNYDFVQAMIVNNHTSLDVEEAAAVRARLNWTSLLPASFTKNYKPVVQTTGNARIVQELPQ
LLDARSAPLIADQAVLQLLPKTYILTCEHDVLRDDGIMYAKRLESAGVEVTLDHFEDGFHGCMIFTSWPTNFSVGIRTRNSYIKWLDQNL

--------------------------------------------------------------
>52508_52508_2_MECOM-NCEH1_MECOM_chr3_169381124_ENST00000494292_NCEH1_chr3_172365904_ENST00000475381_length(transcript)=4450nt_BP=135nt
AGAGAGAGGGAGGGAGCGAGAGGGAGAGCAAAAGAAGGAAAGGATCCAAGAAAAAAAAGCCCCAACCACACACCAGCGGCTGCAGGACTG
GGCACAGCATGAGATCCAAAGGCAGGGCAAGGAAACTGGCCACAAAGTAACCTGATCCACTACCTGGGACTGAGCCATCACCTGCTGGCA
CTGAATTTTATCATTGTTTCTTTTGGCAAAAAAAGCGCGTGGTCTTCTGCCCAAGTGAAGGTGACCGACACAGACTTTGATGGTGTGGAA
GTCAGAGTGTTTGAAGGCCCTCCGAAGCCCGAAGAGCCACTGAAACGCAGCGTCGTTTATATCCACGGAGGAGGCTGGGCCTTGGCAAGT
GCAAAAATCAGGTATTATGATGAGCTGTGTACAGCAATGGCTGAGGAATTGAATGCTGTCATTGTTTCCATTGAATACAGGCTAGTTCCA
AAGGTTTATTTTCCTGAGCAAATTCATGATGTTGTACGGGCCACAAAGTATTTCCTGAAGCCAGAAGTCTTACAGAAGTATATGGTTGAT
CCAGGCAGAATTTGCATTTCTGGTGACAGTGCTGGTGGAAATCTGGCTGCTGCCCTTGGACAACAGTTTACTCAAGATGCCAGCCTAAAA
AATAAGCTCAAACTACAAGCTTTAATTTATCCAGTTCTTCAAGCTTTAGATTTTAACACACCATCTTATCAGCAAAATGTGAACACCCCA
ATCCTGCCCCGCTATGTCATGGTGAAGTATTGGGTGGACTACTTCAAAGGCAACTATGACTTTGTGCAGGCAATGATCGTTAACAATCAC
ACTTCACTTGATGTGGAAGAGGCTGCTGCTGTCAGGGCCCGTCTAAACTGGACATCCCTCTTGCCTGCATCCTTCACAAAGAACTACAAG
CCTGTTGTACAGACCACAGGCAATGCCAGGATTGTCCAGGAGCTTCCTCAGTTGCTGGATGCCCGCTCCGCCCCACTCATTGCAGACCAG
GCAGTGCTGCAGCTCCTCCCAAAGACCTACATTCTGACGTGTGAGCATGATGTCCTCAGAGACGATGGCATCATGTATGCCAAGCGTTTG
GAGAGTGCCGGTGTGGAGGTGACCCTGGATCACTTTGAGGATGGCTTTCACGGATGTATGATTTTCACTAGCTGGCCCACCAACTTCTCA
GTGGGAATCCGGACTAGGAATAGTTACATCAAGTGGCTAGATCAAAACCTGTAAAGGAGCAAAACTTCCAGAAGCCTCGAGCCCCTCTTG
ACCTCCTACACCTGCTTTGGAAAGACATGCACTTTTTAGTTGACTAATTCTTCCTCCCATTCCCCTCTACTTGCGAGTTATGGAATTTCT
ATTCCATAACTGAAGTCTTTATGATAACCTAATTTTTAAAAATGAATTTGACTAACTTAAGTGCAAAACATGTAAATTTGGTTCCCAGAG
TGGGCCAATCTCTCTGTTCTTGTTATCTTAGCCAACTATACTGATACCTACAGCTACAGAAAGCAGGACTAGGAACTGGAAATAACTTTG
GGTCCTGCCTTCATTAGGACGTTCTTTTTAGAAGCAGTTCTTCCAGCTCTGGATCATAGAGTGACCTTTAATAAGTTAAAAAAACGAGGA
CTCCTTAATTCTGCTAGAGTTAACCTTGAGTTCAGAGCAGTATTAAATGCGTGCACTTTCAGGTCAGTACTGGGGACCAAGTACCCTCTG
GTCTTTTGTGAATGGATGGTTTTGTTTCCTATGGGAATTTTGGCAAAGGTTTTCTGGAAAGAACAAGTTTCTCAAAGGACTTTCTTCCTC
TAGAATGTTCATTTTATGAGATCGCTATCTGTAAGTCCAGTTGGATTACAGGAATACTTGAAAGTTACTTTCTACCACTATTAGAAAATA
TGAAGTCGCATGCACTGGATATCTATATATCATTAGGTTTTTGTTGTGTTTTTGGTTATGCTGTCCCCCTTCTCCTTGGGGAGATATTTG
GGAGCAAACTTATTTAGATTTAGAGTAAACTTTTCATTATAGAGCAAGTAAAAACAGACAAATGAAACAACCTAGTGTTTCACATAAAAA
TACTTCTGACATAAAGTACCAAGAGCAGTGTGAATATACTTGGCATAGTCAAAAAAGAAAATACATTTAATATTAGTTCAAAATTGTTAA
AAATACCTTTAGAAGGTCTAGTCTATTATTGAAAACTCAATTTTTTCACTTATATGGCTTTAAAATGGAGCTATTTTGCTACAATATAAT
GTATTGTTTATTTTTTTAAGTTATTTAATGTTAATATACATAGCTAGACTTAAGGTTTTTCAGAAAGATGTCCATAATAAATATTAAAAA
CAATGGTATTTTTTAAAAAACTGCCTTAGGGTTTTAAAACCTTCCCTACAGTTATAACCACGTGTAATTTTGTGGAAATGATATAACAGC
TATTAATACTACTATAACATAGGCATAAATATTTTCGTGTTTATATGCATATACAAGTTAAAATAATTAGAAACTATGACTGCGCCTAGT
AAAGTCATCTAGGTTTATAGTTCAGTAGCTTAGGCAAGGCACACACTGCTCATCTCCGCTTTTTAGGGTCAGAGGAACACAAGCTCATGT
TCTGAGTGAAGGGCGTACACTGGCACCTGGTGTTGCCTAGATCCCCCATCTCCTCCTTCCAGCCAGGTCTGGAAGTTTCAACAGCCCAAG
CTTAACTTCATGTAAAGTCTTCACTGCCAGTGGGAACATCTTTGACACAACAAGACACTCCAATTGTGATTTGAGTTGAGGATCTCTGCC
TGCCTTCCTGCCGTCCTTCCTTCTTCCCCGATCCATGCTACTTTTAGGGGCTGCGGAGAGCAGCAGCAGAGCTGAGTAATGATACAGGGC
ACCACGGAGAGAAAGTAGAACCATTTCACTCCTGGGAAGATGGGGTATTTCCCACTTCCAGCAACGAAATAACAAATGAAAAGTTGCATA
CTTATTGATGTATTGTATGAGCCAGTAGCATTTTATGTACAAAACAGAAGTCAATGCAACAGTATGTATGTGTGCCTGTGTGTGTATAAA
AATAACCATTGAAGCTAACTTGCTAATGTACTTAGGCAAGCCACTTCCCATCTCTGGGCCTCGTCTTTCCTCCCTCTAAAATCAAAGAGC
TGAATTATGTGATCCTTGAGGTCTCTTCCACTTATAATACCAACTGTCTTGTCAGACTGGCAAATTATATTGGCCTCTCCTTATGTGGTG
GTTTTTTTGGTAGGTCATAGTTCCTTATACACAGACACCTGCATCATCGAAGGTCTTTTTTTCCTAAAAAAAAAAAATGGGATTTTAGTT
CTTATTCTGTGATAACTATCCTCCTCATATAATACTATTCTTTTTGACACCATTTGAAGGAACCAATATTTGGACCTTATTTTGAGGTTG
TCTGTCTCGAAGAAAAAGAAAATAAAATGTATAGGCAGGGTTCCTTCAATTGGCATTTTCCCCAGAATTGTGAGCCAAAGCCTATAGTAA
TTGCAGACAGCAAATGATTCCGGATCTCTAAAAGGCTCTCTCAGATGAAAAGGGAGTAAAGGAAAAAAGAGGTCAACCACTGTTTCTGAT
AATGTACTTGAGTTTCATTGTTCTTTTAGTTTGTATTCTTATAAAAAATGTTTACACTCTGCAGATTGATTTTTTTTTTTTAGTACTGTG
GCTTTCTTTTCCTATTTTATGAAAAAAATGATAATCTTTTTGTAAAATTGTCTGTGAAATATAAACATTAATATATAAAGAAAAACCTTG
AAGTGCTGTATAGTGAAGTATAAATTAATGTTTTATTGATTTGTGAAGAATTTAAGACTATTATATAATTATCTTGGTGGATCTATTTTA
TGCATGACCTTTTAACCTTTGACTTTGCTTATTTCCCACTACGAAGGGGAAGGTAGATTTTATGAATGATTTTAATAGCAAATATATTTT
ATAAAGTGAAAATCCAGTGTGGAGGTAGCAAAGCATCTATCTATTCTGAATCATGTTTGGAAATAAAATTGCTCCATCTGGGAATGTGCT
TTCATTTTCCCGTCTCATTTTCTGTTTCCCATTTGAAAACAGTGTTCTCTTCTCTTCTTTCTGTATGCCAAATTGCCAGCCACAATTCTT
TCCCAATCTTCTGCCCAGTGGAGTACTCCAGCTGTCTTTCCTTTAGAGAGGTGGTTCAGTGGCCTCCTTGATGACATTTGTTTCATGTCT
GGATACAGTATGTGTTGCCCTCCTTTGGACTGGCTAGAATATTCATAAAAGCCAGGCAGGCCCTGGGACTATTTTGGGACCTTCAATACA
CATGTTAGGAAAAGGATGATCATAATGCCAAGAGTTTGAGCTGAATTGTTTCAGCCAAAGCATCACTATCACTGAAGGCAGGTTCTCAAA

>52508_52508_2_MECOM-NCEH1_MECOM_chr3_169381124_ENST00000494292_NCEH1_chr3_172365904_ENST00000475381_length(amino acids)=360AA_BP=
MIHYLGLSHHLLALNFIIVSFGKKSAWSSAQVKVTDTDFDGVEVRVFEGPPKPEEPLKRSVVYIHGGGWALASAKIRYYDELCTAMAEEL
NAVIVSIEYRLVPKVYFPEQIHDVVRATKYFLKPEVLQKYMVDPGRICISGDSAGGNLAAALGQQFTQDASLKNKLKLQALIYPVLQALD
FNTPSYQQNVNTPILPRYVMVKYWVDYFKGNYDFVQAMIVNNHTSLDVEEAAAVRARLNWTSLLPASFTKNYKPVVQTTGNARIVQELPQ
LLDARSAPLIADQAVLQLLPKTYILTCEHDVLRDDGIMYAKRLESAGVEVTLDHFEDGFHGCMIFTSWPTNFSVGIRTRNSYIKWLDQNL

--------------------------------------------------------------
>52508_52508_3_MECOM-NCEH1_MECOM_chr3_169381124_ENST00000494292_NCEH1_chr3_172365904_ENST00000538775_length(transcript)=4078nt_BP=135nt
AGAGAGAGGGAGGGAGCGAGAGGGAGAGCAAAAGAAGGAAAGGATCCAAGAAAAAAAAGCCCCAACCACACACCAGCGGCTGCAGGACTG
GGCACAGCATGAGATCCAAAGGCAGGGCAAGGAAACTGGCCACAAAGTAACCTGATCCACTACCTGGGACTGAGCCATCACCTGCTGGCA
CTGAATTTTATCATTGTTTCTTTTGGCAAAAAAAGCGCGTGGTCTTCTGCCCAAGTGAAGGTGACCGACACAGACTTTGATGGTGTGGAA
GTCAGAGTGTTTGAAGGCCCTCCGAAGCCCGAAGAGCCACTGAAACGCAGCGTCGTTTATATCCACGGAGGAGGCTGGGCCTTGGCAAGT
GCAAGTGCGTCCTGGTCACCTTCAGATGAAATCAGGTATTATGATGAGCTGTGTACAGCAATGGCTGAGGAATTGAATGCTGTCATTGTT
TCCATTGAATACAGGCTAGTTCCAAAGGTTTATTTTCCTGAGCAAATTCATGATGTTGTACGGGCCACAAAGTATTTCCTGAAGCCAGAA
GTCTTACAGAAGTATATGGTTGATCCAGGCAGAATTTGCATTTCTGGTGACAGTGCTGGTGGAAATCTGGCTGCTGCCCTTGGACAACAG
TTTACTCAAGATGCCAGCCTAAAAAATAAGCTCAAACTACAAGCTTTAATTTATCCAGTTCTTCAAGCTTTAGATTTTAACACACCATCT
TATCAGCAAAATGTGAACACCCCAATCCTGCCCCGCTATGTCATGGTGAAGTATTGGGTGGACTACTTCAAAGGCAACTATGACTTTGTG
CAGGCAATGATCGTTAACAATCACACTTCACTTGATGTGGAAGAGGCTGCTGCTGTCAGGGCCCGTCTAAACTGGACATCCCTCTTGCCT
GCATCCTTCACAAAGAACTACAAGCCTGTTGTACAGACCACAGGCAATGCCAGGATTGTCCAGGAGCTTCCTCAGTTGCTGGATGCCCGC
TCCGCCCCACTCATTGCAGACCAGGCAGTGCTGCAGCTCCTCCCAAAGACCTACATTCTGACGTGTGAGCATGATGTCCTCAGAGACGAT
GGCATCATGTATGCCAAGCGTTTGGAGAGTGCCGGTGTGGAGGTGACCCTGGATCACTTTGAGGATGGCTTTCACGGATGTATGATTTTC
ACTAGCTGGCCCACCAACTTCTCAGTGGGAATCCGGACTAGGAATAGTTACATCAAGTGGCTAGATCAAAACCTGTAAAGGAGCAAAACT
TCCAGAAGCCTCGAGCCCCTCTTGACCTCCTACACCTGCTTTGGAAAGACATGCACTTTTTAGTTGACTAATTCTTCCTCCCATTCCCCT
CTACTTGCGAGTTATGGAATTTCTATTCCATAACTGAAGTCTTTATGATAACCTAATTTTTAAAAATGAATTTGACTAACTTAAGTGCAA
AACATGTAAATTTGGTTCCCAGAGTGGGCCAATCTCTCTGTTCTTGTTATCTTAGCCAACTATACTGATACCTACAGCTACAGAAAGCAG
GACTAGGAACTGGAAATAACTTTGGGTCCTGCCTTCATTAGGACGTTCTTTTTAGAAGCAGTTCTTCCAGCTCTGGATCATAGAGTGACC
TTTAATAAGTTAAAAAAACGAGGACTCCTTAATTCTGCTAGAGTTAACCTTGAGTTCAGAGCAGTATTAAATGCGTGCACTTTCAGGTCA
GTACTGGGGACCAAGTACCCTCTGGTCTTTTGTGAATGGATGGTTTTGTTTCCTATGGGAATTTTGGCAAAGGTTTTCTGGAAAGAACAA
GTTTCTCAAAGGACTTTCTTCCTCTAGAATGTTCATTTTATGAGATCGCTATCTGTAAGTCCAGTTGGATTACAGGAATACTTGAAAGTT
ACTTTCTACCACTATTAGAAAATATGAAGTCGCATGCACTGGATATCTATATATCATTAGGTTTTTGTTGTGTTTTTGGTTATGCTGTCC
CCCTTCTCCTTGGGGAGATATTTGGGAGCAAACTTATTTAGATTTAGAGTAAACTTTTCATTATAGAGCAAGTAAAAACAGACAAATGAA
ACAACCTAGTGTTTCACATAAAAATACTTCTGACATAAAGTACCAAGAGCAGTGTGAATATACTTGGCATAGTCAAAAAAGAAAATACAT
TTAATATTAGTTCAAAATTGTTAAAAATACCTTTAGAAGGTCTAGTCTATTATTGAAAACTCAATTTTTTCACTTATATGGCTTTAAAAT
GGAGCTATTTTGCTACAATATAATGTATTGTTTATTTTTTTAAGTTATTTAATGTTAATATACATAGCTAGACTTAAGGTTTTTCAGAAA
GATGTCCATAATAAATATTAAAAACAATGGTATTTTTTAAAAAACTGCCTTAGGGTTTTAAAACCTTCCCTACAGTTATAACCACGTGTA
ATTTTGTGGAAATGATATAACAGCTATTAATACTACTATAACATAGGCATAAATATTTTCGTGTTTATATGCATATACAAGTTAAAATAA
TTAGAAACTATGACTGCGCCTAGTAAAGTCATCTAGGTTTATAGTTCAGTAGCTTAGGCAAGGCACACACTGCTCATCTCCGCTTTTTAG
GGTCAGAGGAACACAAGCTCATGTTCTGAGTGAAGGGCGTACACTGGCACCTGGTGTTGCCTAGATCCCCCATCTCCTCCTTCCAGCCAG
GTCTGGAAGTTTCAACAGCCCAAGCTTAACTTCATGTAAAGTCTTCACTGCCAGTGGGAACATCTTTGACACAACAAGACACTCCAATTG
TGATTTGAGTTGAGGATCTCTGCCTGCCTTCCTGCCGTCCTTCCTTCTTCCCCGATCCATGCTACTTTTAGGGGCTGCGGAGAGCAGCAG
CAGAGCTGAGTAATGATACAGGGCACCACGGAGAGAAAGTAGAACCATTTCACTCCTGGGAAGATGGGGTATTTCCCACTTCCAGCAACG
AAATAACAAATGAAAAGTTGCATACTTATTGATGTATTGTATGAGCCAGTAGCATTTTATGTACAAAACAGAAGTCAATGCAACAGTATG
TATGTGTGCCTGTGTGTGTATAAAAATAACCATTGAAGCTAACTTGCTAATGTACTTAGGCAAGCCACTTCCCATCTCTGGGCCTCGTCT
TTCCTCCCTCTAAAATCAAAGAGCTGAATTATGTGATCCTTGAGGTCTCTTCCACTTATAATACCAACTGTCTTGTCAGACTGGCAAATT
ATATTGGCCTCTCCTTATGTGGTGGTTTTTTTGGTAGGTCATAGTTCCTTATACACAGACACCTGCATCATCGAAGGTCTTTTTTTCCTA
AAAAAAAAAAATGGGATTTTAGTTCTTATTCTGTGATAACTATCCTCCTCATATAATACTATTCTTTTTGACACCATTTGAAGGAACCAA
TATTTGGACCTTATTTTGAGGTTGTCTGTCTCGAAGAAAAAGAAAATAAAATGTATAGGCAGGGTTCCTTCAATTGGCATTTTCCCCAGA
ATTGTGAGCCAAAGCCTATAGTAATTGCAGACAGCAAATGATTCCGGATCTCTAAAAGGCTCTCTCAGATGAAAAGGGAGTAAAGGAAAA
AAGAGGTCAACCACTGTTTCTGATAATGTACTTGAGTTTCATTGTTCTTTTAGTTTGTATTCTTATAAAAAATGTTTACACTCTGCAGAT
TGATTTTTTTTTTTTAGTACTGTGGCTTTCTTTTCCTATTTTATGAAAAAAATGATAATCTTTTTGTAAAATTGTCTGTGAAATATAAAC
ATTAATATATAAAGAAAAACCTTGAAGTGCTGTATAGTGAAGTATAAATTAATGTTTTATTGATTTGTGAAGAATTTAAGACTATTATAT
AATTATCTTGGTGGATCTATTTTATGCATGACCTTTTAACCTTTGACTTTGCTTATTTCCCACTACGAAGGGGAAGGTAGATTTTATGAA
TGATTTTAATAGCAAATATATTTTATAAAGTGAAAATCCAGTGTGGAGGTAGCAAAGCATCTATCTATTCTGAATCATGTTTGGAAATAA

>52508_52508_3_MECOM-NCEH1_MECOM_chr3_169381124_ENST00000494292_NCEH1_chr3_172365904_ENST00000538775_length(amino acids)=368AA_BP=
MIHYLGLSHHLLALNFIIVSFGKKSAWSSAQVKVTDTDFDGVEVRVFEGPPKPEEPLKRSVVYIHGGGWALASASASWSPSDEIRYYDEL
CTAMAEELNAVIVSIEYRLVPKVYFPEQIHDVVRATKYFLKPEVLQKYMVDPGRICISGDSAGGNLAAALGQQFTQDASLKNKLKLQALI
YPVLQALDFNTPSYQQNVNTPILPRYVMVKYWVDYFKGNYDFVQAMIVNNHTSLDVEEAAAVRARLNWTSLLPASFTKNYKPVVQTTGNA
RIVQELPQLLDARSAPLIADQAVLQLLPKTYILTCEHDVLRDDGIMYAKRLESAGVEVTLDHFEDGFHGCMIFTSWPTNFSVGIRTRNSY

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MECOM-NCEH1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMECOMchr3:169381124chr3:172365904ENST00000264674-117189_44001117.0MAPK9%2C SMAD3 and probably SUV39H1
HgeneMECOMchr3:169381124chr3:172365904ENST00000392736-116189_44001052.0MAPK9%2C SMAD3 and probably SUV39H1
HgeneMECOMchr3:169381124chr3:172365904ENST00000433243-117189_44001053.0MAPK9%2C SMAD3 and probably SUV39H1
HgeneMECOMchr3:169381124chr3:172365904ENST00000464456-115189_44001043.0MAPK9%2C SMAD3 and probably SUV39H1
HgeneMECOMchr3:169381124chr3:172365904ENST00000468789-116189_44001052.0MAPK9%2C SMAD3 and probably SUV39H1
HgeneMECOMchr3:169381124chr3:172365904ENST00000472280-116189_44001053.0MAPK9%2C SMAD3 and probably SUV39H1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for MECOM-NCEH1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for MECOM-NCEH1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource