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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MECP2-DNASE1L1 (FusionGDB2 ID:52521)

Fusion Gene Summary for MECP2-DNASE1L1

Fusion gene summary

Fusion gene information	Fusion gene name: MECP2-DNASE1L1
	Fusion gene ID: 52521
		Hgene	Tgene
	Gene symbol	MECP2	DNASE1L1
	Gene ID	4204	1774
	Gene name	methyl-CpG binding protein 2	deoxyribonuclease 1 like 1
	Synonyms	AUTSX3\|MRX16\|MRX79\|MRXS13\|MRXSL\|PPMX\|RS\|RTS\|RTT	DNAS1L1\|DNASEX\|DNL1L\|G4.8\|XIB
	Cytomap	Xq28	Xq28
	Type of gene	protein-coding	protein-coding
	Description	methyl-CpG-binding protein 2meCp-2 protein	deoxyribonuclease-1-like 1DNase I, lysosomal-likeDNase I-like 1DNase I-like, muscle-specificdeoxyribonuclease I-like 1
	Modification date	20200315	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000303391, ENST00000407218, ENST00000453960, ENST00000460227,	ENST00000369809, ENST00000393638,
Fusion gene scores	* DoF score	8 X 7 X 4=224	2 X 2 X 2=8
	# samples	8	2
	** MAII score	log2(8/224*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context	PubMed: MECP2 [Title/Abstract] AND DNASE1L1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MECP2(153363060)-DNASE1L1(153631963), # samples:2
Anticipated loss of major functional domain due to fusion event.	MECP2-DNASE1L1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. MECP2-DNASE1L1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MECP2	GO:0010629	negative regulation of gene expression	23960241
Hgene	MECP2	GO:0043537	negative regulation of blood vessel endothelial cell migration	23960241
Hgene	MECP2	GO:0045892	negative regulation of transcription, DNA-templated	11441023
Hgene	MECP2	GO:1905643	positive regulation of DNA methylation	23960241

Fusion gene breakpoints across MECP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DNASE1L1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	TCGA-E8-A2JQ-11A	MECP2	chrX	153357642	-	DNASE1L1	chrX	153631963	-
ChimerDB4	Non-Cancer	TCGA-E8-A2JQ-11A	MECP2	chrX	153363060	-	DNASE1L1	chrX	153631963	-
ChimerDB4	Non-Cancer	TCGA-E8-A2JQ-11A	MECP2	chrX	153363061	-	DNASE1L1	chrX	153631963	-

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Fusion Gene ORF analysis for MECP2-DNASE1L1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000303391	ENST00000369809	MECP2	chrX	153363060	-	DNASE1L1	chrX	153631963	-
5UTR-3CDS	ENST00000303391	ENST00000369809	MECP2	chrX	153363061	-	DNASE1L1	chrX	153631963	-
5UTR-3CDS	ENST00000303391	ENST00000393638	MECP2	chrX	153363060	-	DNASE1L1	chrX	153631963	-
5UTR-3CDS	ENST00000303391	ENST00000393638	MECP2	chrX	153363061	-	DNASE1L1	chrX	153631963	-
5UTR-3CDS	ENST00000407218	ENST00000369809	MECP2	chrX	153363060	-	DNASE1L1	chrX	153631963	-
5UTR-3CDS	ENST00000407218	ENST00000369809	MECP2	chrX	153363061	-	DNASE1L1	chrX	153631963	-
5UTR-3CDS	ENST00000407218	ENST00000393638	MECP2	chrX	153363060	-	DNASE1L1	chrX	153631963	-
5UTR-3CDS	ENST00000407218	ENST00000393638	MECP2	chrX	153363061	-	DNASE1L1	chrX	153631963	-
Frame-shift	ENST00000453960	ENST00000369809	MECP2	chrX	153363060	-	DNASE1L1	chrX	153631963	-
Frame-shift	ENST00000453960	ENST00000369809	MECP2	chrX	153363061	-	DNASE1L1	chrX	153631963	-
Frame-shift	ENST00000453960	ENST00000393638	MECP2	chrX	153363060	-	DNASE1L1	chrX	153631963	-
Frame-shift	ENST00000453960	ENST00000393638	MECP2	chrX	153363061	-	DNASE1L1	chrX	153631963	-
In-frame	ENST00000303391	ENST00000369809	MECP2	chrX	153357642	-	DNASE1L1	chrX	153631963	-
In-frame	ENST00000303391	ENST00000393638	MECP2	chrX	153357642	-	DNASE1L1	chrX	153631963	-
In-frame	ENST00000407218	ENST00000369809	MECP2	chrX	153357642	-	DNASE1L1	chrX	153631963	-
In-frame	ENST00000407218	ENST00000393638	MECP2	chrX	153357642	-	DNASE1L1	chrX	153631963	-
intron-3CDS	ENST00000453960	ENST00000369809	MECP2	chrX	153357642	-	DNASE1L1	chrX	153631963	-
intron-3CDS	ENST00000453960	ENST00000393638	MECP2	chrX	153357642	-	DNASE1L1	chrX	153631963	-
intron-3CDS	ENST00000460227	ENST00000369809	MECP2	chrX	153357642	-	DNASE1L1	chrX	153631963	-
intron-3CDS	ENST00000460227	ENST00000369809	MECP2	chrX	153363060	-	DNASE1L1	chrX	153631963	-
intron-3CDS	ENST00000460227	ENST00000369809	MECP2	chrX	153363061	-	DNASE1L1	chrX	153631963	-
intron-3CDS	ENST00000460227	ENST00000393638	MECP2	chrX	153357642	-	DNASE1L1	chrX	153631963	-
intron-3CDS	ENST00000460227	ENST00000393638	MECP2	chrX	153363060	-	DNASE1L1	chrX	153631963	-
intron-3CDS	ENST00000460227	ENST00000393638	MECP2	chrX	153363061	-	DNASE1L1	chrX	153631963	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000303391	MECP2	chrX	153357642	-	ENST00000393638	DNASE1L1	chrX	153631963	-	2343	276	250	873	207
ENST00000303391	MECP2	chrX	153357642	-	ENST00000369809	DNASE1L1	chrX	153631963	-	2343	276	250	873	207
ENST00000407218	MECP2	chrX	153357642	-	ENST00000393638	DNASE1L1	chrX	153631963	-	2279	212	186	809	207
ENST00000407218	MECP2	chrX	153357642	-	ENST00000369809	DNASE1L1	chrX	153631963	-	2279	212	186	809	207

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000303391	ENST00000393638	MECP2	chrX	153357642	-	DNASE1L1	chrX	153631963	-	0.007697781	0.9923022
ENST00000303391	ENST00000369809	MECP2	chrX	153357642	-	DNASE1L1	chrX	153631963	-	0.007697781	0.9923022
ENST00000407218	ENST00000393638	MECP2	chrX	153357642	-	DNASE1L1	chrX	153631963	-	0.009723089	0.99027693
ENST00000407218	ENST00000369809	MECP2	chrX	153357642	-	DNASE1L1	chrX	153631963	-	0.009723089	0.99027693

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Fusion Genomic Features for MECP2-DNASE1L1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MECP2-DNASE1L1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:153363060/chrX:153631963)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MECP2

chrX:153357642

chrX:153631963

ENST00000303391

366_372

487.0

Compositional bias

Note=His-rich

Hgene

MECP2

chrX:153357642

chrX:153631963

ENST00000303391

376_405

487.0

Compositional bias

Note=Pro-rich

Hgene

MECP2

chrX:153357642

chrX:153631963

ENST00000453960

366_372

499.0

Compositional bias

Note=His-rich

Hgene

MECP2

chrX:153357642

chrX:153631963

ENST00000453960

376_405

499.0

Compositional bias

Note=Pro-rich

Hgene

MECP2

chrX:153357642

chrX:153631963

ENST00000303391

185_197

487.0

DNA binding

Note=A.T hook 1

Hgene

MECP2

chrX:153357642

chrX:153631963

ENST00000303391

265_277

487.0

DNA binding

Note=A.T hook 2

Hgene

MECP2

chrX:153357642

chrX:153631963

ENST00000453960

185_197

499.0

DNA binding

Note=A.T hook 1

Hgene

MECP2

chrX:153357642

chrX:153631963

ENST00000453960

265_277

499.0

DNA binding

Note=A.T hook 2

Hgene

MECP2

chrX:153357642

chrX:153631963

ENST00000303391

90_162

487.0

Domain

MBD

Hgene

MECP2

chrX:153357642

chrX:153631963

ENST00000453960

90_162

499.0

Domain

MBD

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Fusion Gene Sequence for MECP2-DNASE1L1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>52521_52521_1_MECP2-DNASE1L1_MECP2_chrX_153357642_ENST00000303391_DNASE1L1_chrX_153631963_ENST00000369809_length(transcript)=2343nt_BP=276nt
GCGCGACGTCGGCCGTGCGGGGTCCCGGCGTCGGCGGCGCGCGCGCTCCCTCCTCTCGGAGAGAGGGCTGTGGTAAAAGCCGTCCGGAAA
ATGGCCGCCGCCGCCGCCGCCGCGCCGAGCGGAGGAGGAGGAGGAGGCGAGGAGGAGAGACTGCTCCATAAAAATACAGACTCACCAGTT
CCTGCTTTGATGTGACATGTGACTCCCCAGAATACACCTTGCTTCTGTAGACCAGCTCCAACAGGATTCCATGGTAGCTGGGATGTTAGG
GCTCAGGTCACACAAAACACAGGTCCTGAGTTCCTACGTGTACAACGATGAGGATGACGTCTTTGCCCGGGAGCCATTTGTGGCCCAGTT
CTCTTTGCCCAGCAATGTCCTTCCCAGCCTGGTGTTGGTCCCGCTGCACACCACTCCTAAGGCCGTAGAGAAGGAGCTGAACGCCCTCTA
CGATGTGTTTCTGGAGGTCTCCCAGCACTGGCAGAGCAAGGACGTGATCCTGCTTGGGGACTTCAATGCTGACTGCGCTTCACTGACCAA
AAAGCGCCTGGACAAGCTGGAGCTGCGGACTGAGCCAGGCTTCCACTGGGTGATTGCCGATGGGGAGGACACCACAGTGCGGGCCAGCAC
CCACTGCACCTATGACCGCGTCGTGCTGCACGGGGAGCGCTGCCGGAGTCTGCTGCACACTGCGGCTGCCTTTGACTTCCCCACGAGCTT
CCAGCTCACCGAGGAGGAGGCCCTCAACATCAGTGACCACTACCCCGTGGAGGTGGAGCTGAAGCTGAGCCAGGCGCACAGCGTCCAGCC
TCTCAGCCTCACTGTTCTGTTGCTGCTATCACTCCTGTCCCCTCAGCTGTGCCCTGCTGCCTGAGCGTCCCCCTACCCCCCCAGGGCCTG
CTGCCTTTTGGGACTTAAACCCCAGCCTCCCCCGTCCATCCAGCCCTGGGGCTGGGGGGCTTCAACTATAGTTGCCCTGTGACTGTAGTC
CACCCCTGCCTGCCTTGTTTGATTTGGCTCTTGTTCTTTGGTTGGGCTTGTGCCTAGATTAGGAGAGGAAGCCAGGGGCCCTGCACTCAT
GCCACCTGCCAGGTAGTGTAGTATCAGGAGTGGAGACAAAGTGGGCTCTGGGTTGGGGTAGGGGAAGGGAGGGTTCAGAAAGAGGAATGA
AGATGTTGTATGACAAGAAGGAAAGTTACTGAGAACAAAAACCCAGATTGGTGAGATAGGACACTTGTGCAGCAGATATGCCAATGGGCC
ATGTTTATTGTGGATTGGTAAGAATCACCAGGAAACCATTAAGCCCCAATAGCTACAAGGAGGGTGGTTAATCTGCTATATCAAACTCCT
TCCCTGAAACCAGCAAACACCGGGAAACATTTTGGCTCATTATAATCCGGTGAACAATGCAGTCAGGCCTGTTATAACCGCTGAGCAGCC
ACACTCGCACCTCCTGGGTGCTGTAGTCTGTGTTGGTACAGGCTTCTGCATGCCTGGTAAAGTCCAGCCAAGGCTGGTCAAGGCAACATC
TCCACACAGAAAATCTGCACCAGTTATGTAAGCTAAAAAGCTGTGTGAACCCAGGTGTCCCGGAAAGGGGCTGCAGGACACAGCAAAATG
CCAGCAGCGTGCCGGACCCCTCCCTTCCATCCTCCTCTCCAAAGAACAGAGGTCAGGAAAAACACTGGCTGGGACGCTAGAAGGGTCATG
TGTTAACTATAATCACATTTATGGTTTGGAACCATCACCCCAAGGTAAAAAAAAAATAAAAGGTATTCCCAGGTATGTTTGGCAAAATAA
AATAAAGGTAATTAAAAACCTAAGAAATGGCTGTAAACTGAGATTACAAAAAACCAGAGGCCTTTTGGGAGCCACAGGCTGGGGGCTGGG
GCCAACATACCCCAGCTCTGGGACCAAAAGCCTTTGGAGTCCTGTCCCTGGATACAGATGCTCAGGCCACCCACCTAGCACTCCTCTCAT
TTTTGCTGCTCCCCCAAAAGCCAGCGCTGTTCTACAATAGTTCAGGTCAGACATCTAAGATCCCCAGGCCAAACCATGCCACACACGTGT
CTGTTCCGAGGTCTTGTTACAAATGACCAAAGGTTAGCCTAGACCTTTGGTCAGGTGGTGAAGGCCCTGGGAATGCAGGTTCTAGAAGGG
GTGGGGGCATGGGGCCCAGGAGGTTGCTAGAGATAGGAAATGGGGCAAATCGCAGGTGACCTCAGCAGTACCTGGATGATTCCCACCAAG
GAGGAATGGCCAAACCAGATGGGTGAGAACAAGCCCAATGTGATGCACACCTACCCTTGCTAAATAAACGCTGCTGGTCAGCCTCTAGCC

>52521_52521_1_MECP2-DNASE1L1_MECP2_chrX_153357642_ENST00000303391_DNASE1L1_chrX_153631963_ENST00000369809_length(amino acids)=207AA_BP=8
MVAGMLGLRSHKTQVLSSYVYNDEDDVFAREPFVAQFSLPSNVLPSLVLVPLHTTPKAVEKELNALYDVFLEVSQHWQSKDVILLGDFNA
DCASLTKKRLDKLELRTEPGFHWVIADGEDTTVRASTHCTYDRVVLHGERCRSLLHTAAAFDFPTSFQLTEEEALNISDHYPVEVELKLS

--------------------------------------------------------------
>52521_52521_2_MECP2-DNASE1L1_MECP2_chrX_153357642_ENST00000303391_DNASE1L1_chrX_153631963_ENST00000393638_length(transcript)=2343nt_BP=276nt
GCGCGACGTCGGCCGTGCGGGGTCCCGGCGTCGGCGGCGCGCGCGCTCCCTCCTCTCGGAGAGAGGGCTGTGGTAAAAGCCGTCCGGAAA
ATGGCCGCCGCCGCCGCCGCCGCGCCGAGCGGAGGAGGAGGAGGAGGCGAGGAGGAGAGACTGCTCCATAAAAATACAGACTCACCAGTT
CCTGCTTTGATGTGACATGTGACTCCCCAGAATACACCTTGCTTCTGTAGACCAGCTCCAACAGGATTCCATGGTAGCTGGGATGTTAGG
GCTCAGGTCACACAAAACACAGGTCCTGAGTTCCTACGTGTACAACGATGAGGATGACGTCTTTGCCCGGGAGCCATTTGTGGCCCAGTT
CTCTTTGCCCAGCAATGTCCTTCCCAGCCTGGTGTTGGTCCCGCTGCACACCACTCCTAAGGCCGTAGAGAAGGAGCTGAACGCCCTCTA
CGATGTGTTTCTGGAGGTCTCCCAGCACTGGCAGAGCAAGGACGTGATCCTGCTTGGGGACTTCAATGCTGACTGCGCTTCACTGACCAA
AAAGCGCCTGGACAAGCTGGAGCTGCGGACTGAGCCAGGCTTCCACTGGGTGATTGCCGATGGGGAGGACACCACAGTGCGGGCCAGCAC
CCACTGCACCTATGACCGCGTCGTGCTGCACGGGGAGCGCTGCCGGAGTCTGCTGCACACTGCGGCTGCCTTTGACTTCCCCACGAGCTT
CCAGCTCACCGAGGAGGAGGCCCTCAACATCAGTGACCACTACCCCGTGGAGGTGGAGCTGAAGCTGAGCCAGGCGCACAGCGTCCAGCC
TCTCAGCCTCACTGTTCTGTTGCTGCTATCACTCCTGTCCCCTCAGCTGTGCCCTGCTGCCTGAGCGTCCCCCTACCCCCCCAGGGCCTG
CTGCCTTTTGGGACTTAAACCCCAGCCTCCCCCGTCCATCCAGCCCTGGGGCTGGGGGGCTTCAACTATAGTTGCCCTGTGACTGTAGTC
CACCCCTGCCTGCCTTGTTTGATTTGGCTCTTGTTCTTTGGTTGGGCTTGTGCCTAGATTAGGAGAGGAAGCCAGGGGCCCTGCACTCAT
GCCACCTGCCAGGTAGTGTAGTATCAGGAGTGGAGACAAAGTGGGCTCTGGGTTGGGGTAGGGGAAGGGAGGGTTCAGAAAGAGGAATGA
AGATGTTGTATGACAAGAAGGAAAGTTACTGAGAACAAAAACCCAGATTGGTGAGATAGGACACTTGTGCAGCAGATATGCCAATGGGCC
ATGTTTATTGTGGATTGGTAAGAATCACCAGGAAACCATTAAGCCCCAATAGCTACAAGGAGGGTGGTTAATCTGCTATATCAAACTCCT
TCCCTGAAACCAGCAAACACCGGGAAACATTTTGGCTCATTATAATCCGGTGAACAATGCAGTCAGGCCTGTTATAACCGCTGAGCAGCC
ACACTCGCACCTCCTGGGTGCTGTAGTCTGTGTTGGTACAGGCTTCTGCATGCCTGGTAAAGTCCAGCCAAGGCTGGTCAAGGCAACATC
TCCACACAGAAAATCTGCACCAGTTATGTAAGCTAAAAAGCTGTGTGAACCCAGGTGTCCCGGAAAGGGGCTGCAGGACACAGCAAAATG
CCAGCAGCGTGCCGGACCCCTCCCTTCCATCCTCCTCTCCAAAGAACAGAGGTCAGGAAAAACACTGGCTGGGACGCTAGAAGGGTCATG
TGTTAACTATAATCACATTTATGGTTTGGAACCATCACCCCAAGGTAAAAAAAAAATAAAAGGTATTCCCAGGTATGTTTGGCAAAATAA
AATAAAGGTAATTAAAAACCTAAGAAATGGCTGTAAACTGAGATTACAAAAAACCAGAGGCCTTTTGGGAGCCACAGGCTGGGGGCTGGG
GCCAACATACCCCAGCTCTGGGACCAAAAGCCTTTGGAGTCCTGTCCCTGGATACAGATGCTCAGGCCACCCACCTAGCACTCCTCTCAT
TTTTGCTGCTCCCCCAAAAGCCAGCGCTGTTCTACAATAGTTCAGGTCAGACATCTAAGATCCCCAGGCCAAACCATGCCACACACGTGT
CTGTTCCGAGGTCTTGTTACAAATGACCAAAGGTTAGCCTAGACCTTTGGTCAGGTGGTGAAGGCCCTGGGAATGCAGGTTCTAGAAGGG
GTGGGGGCATGGGGCCCAGGAGGTTGCTAGAGATAGGAAATGGGGCAAATCGCAGGTGACCTCAGCAGTACCTGGATGATTCCCACCAAG
GAGGAATGGCCAAACCAGATGGGTGAGAACAAGCCCAATGTGATGCACACCTACCCTTGCTAAATAAACGCTGCTGGTCAGCCTCTAGCC

>52521_52521_2_MECP2-DNASE1L1_MECP2_chrX_153357642_ENST00000303391_DNASE1L1_chrX_153631963_ENST00000393638_length(amino acids)=207AA_BP=8
MVAGMLGLRSHKTQVLSSYVYNDEDDVFAREPFVAQFSLPSNVLPSLVLVPLHTTPKAVEKELNALYDVFLEVSQHWQSKDVILLGDFNA
DCASLTKKRLDKLELRTEPGFHWVIADGEDTTVRASTHCTYDRVVLHGERCRSLLHTAAAFDFPTSFQLTEEEALNISDHYPVEVELKLS

--------------------------------------------------------------
>52521_52521_3_MECP2-DNASE1L1_MECP2_chrX_153357642_ENST00000407218_DNASE1L1_chrX_153631963_ENST00000369809_length(transcript)=2279nt_BP=212nt
GGGCTGTGGTAAAAGCCGTCCGGAAAATGGCCGCCGCCGCCGCCGCCGCGCCGAGCGGAGGAGGAGGAGGAGGCGAGGAGGAGAGACTGC
TCCATAAAAATACAGACTCACCAGTTCCTGCTTTGATGTGACATGTGACTCCCCAGAATACACCTTGCTTCTGTAGACCAGCTCCAACAG
GATTCCATGGTAGCTGGGATGTTAGGGCTCAGGTCACACAAAACACAGGTCCTGAGTTCCTACGTGTACAACGATGAGGATGACGTCTTT
GCCCGGGAGCCATTTGTGGCCCAGTTCTCTTTGCCCAGCAATGTCCTTCCCAGCCTGGTGTTGGTCCCGCTGCACACCACTCCTAAGGCC
GTAGAGAAGGAGCTGAACGCCCTCTACGATGTGTTTCTGGAGGTCTCCCAGCACTGGCAGAGCAAGGACGTGATCCTGCTTGGGGACTTC
AATGCTGACTGCGCTTCACTGACCAAAAAGCGCCTGGACAAGCTGGAGCTGCGGACTGAGCCAGGCTTCCACTGGGTGATTGCCGATGGG
GAGGACACCACAGTGCGGGCCAGCACCCACTGCACCTATGACCGCGTCGTGCTGCACGGGGAGCGCTGCCGGAGTCTGCTGCACACTGCG
GCTGCCTTTGACTTCCCCACGAGCTTCCAGCTCACCGAGGAGGAGGCCCTCAACATCAGTGACCACTACCCCGTGGAGGTGGAGCTGAAG
CTGAGCCAGGCGCACAGCGTCCAGCCTCTCAGCCTCACTGTTCTGTTGCTGCTATCACTCCTGTCCCCTCAGCTGTGCCCTGCTGCCTGA
GCGTCCCCCTACCCCCCCAGGGCCTGCTGCCTTTTGGGACTTAAACCCCAGCCTCCCCCGTCCATCCAGCCCTGGGGCTGGGGGGCTTCA
ACTATAGTTGCCCTGTGACTGTAGTCCACCCCTGCCTGCCTTGTTTGATTTGGCTCTTGTTCTTTGGTTGGGCTTGTGCCTAGATTAGGA
GAGGAAGCCAGGGGCCCTGCACTCATGCCACCTGCCAGGTAGTGTAGTATCAGGAGTGGAGACAAAGTGGGCTCTGGGTTGGGGTAGGGG
AAGGGAGGGTTCAGAAAGAGGAATGAAGATGTTGTATGACAAGAAGGAAAGTTACTGAGAACAAAAACCCAGATTGGTGAGATAGGACAC
TTGTGCAGCAGATATGCCAATGGGCCATGTTTATTGTGGATTGGTAAGAATCACCAGGAAACCATTAAGCCCCAATAGCTACAAGGAGGG
TGGTTAATCTGCTATATCAAACTCCTTCCCTGAAACCAGCAAACACCGGGAAACATTTTGGCTCATTATAATCCGGTGAACAATGCAGTC
AGGCCTGTTATAACCGCTGAGCAGCCACACTCGCACCTCCTGGGTGCTGTAGTCTGTGTTGGTACAGGCTTCTGCATGCCTGGTAAAGTC
CAGCCAAGGCTGGTCAAGGCAACATCTCCACACAGAAAATCTGCACCAGTTATGTAAGCTAAAAAGCTGTGTGAACCCAGGTGTCCCGGA
AAGGGGCTGCAGGACACAGCAAAATGCCAGCAGCGTGCCGGACCCCTCCCTTCCATCCTCCTCTCCAAAGAACAGAGGTCAGGAAAAACA
CTGGCTGGGACGCTAGAAGGGTCATGTGTTAACTATAATCACATTTATGGTTTGGAACCATCACCCCAAGGTAAAAAAAAAATAAAAGGT
ATTCCCAGGTATGTTTGGCAAAATAAAATAAAGGTAATTAAAAACCTAAGAAATGGCTGTAAACTGAGATTACAAAAAACCAGAGGCCTT
TTGGGAGCCACAGGCTGGGGGCTGGGGCCAACATACCCCAGCTCTGGGACCAAAAGCCTTTGGAGTCCTGTCCCTGGATACAGATGCTCA
GGCCACCCACCTAGCACTCCTCTCATTTTTGCTGCTCCCCCAAAAGCCAGCGCTGTTCTACAATAGTTCAGGTCAGACATCTAAGATCCC
CAGGCCAAACCATGCCACACACGTGTCTGTTCCGAGGTCTTGTTACAAATGACCAAAGGTTAGCCTAGACCTTTGGTCAGGTGGTGAAGG
CCCTGGGAATGCAGGTTCTAGAAGGGGTGGGGGCATGGGGCCCAGGAGGTTGCTAGAGATAGGAAATGGGGCAAATCGCAGGTGACCTCA
GCAGTACCTGGATGATTCCCACCAAGGAGGAATGGCCAAACCAGATGGGTGAGAACAAGCCCAATGTGATGCACACCTACCCTTGCTAAA

>52521_52521_3_MECP2-DNASE1L1_MECP2_chrX_153357642_ENST00000407218_DNASE1L1_chrX_153631963_ENST00000369809_length(amino acids)=207AA_BP=8
MVAGMLGLRSHKTQVLSSYVYNDEDDVFAREPFVAQFSLPSNVLPSLVLVPLHTTPKAVEKELNALYDVFLEVSQHWQSKDVILLGDFNA
DCASLTKKRLDKLELRTEPGFHWVIADGEDTTVRASTHCTYDRVVLHGERCRSLLHTAAAFDFPTSFQLTEEEALNISDHYPVEVELKLS

--------------------------------------------------------------
>52521_52521_4_MECP2-DNASE1L1_MECP2_chrX_153357642_ENST00000407218_DNASE1L1_chrX_153631963_ENST00000393638_length(transcript)=2279nt_BP=212nt
GGGCTGTGGTAAAAGCCGTCCGGAAAATGGCCGCCGCCGCCGCCGCCGCGCCGAGCGGAGGAGGAGGAGGAGGCGAGGAGGAGAGACTGC
TCCATAAAAATACAGACTCACCAGTTCCTGCTTTGATGTGACATGTGACTCCCCAGAATACACCTTGCTTCTGTAGACCAGCTCCAACAG
GATTCCATGGTAGCTGGGATGTTAGGGCTCAGGTCACACAAAACACAGGTCCTGAGTTCCTACGTGTACAACGATGAGGATGACGTCTTT
GCCCGGGAGCCATTTGTGGCCCAGTTCTCTTTGCCCAGCAATGTCCTTCCCAGCCTGGTGTTGGTCCCGCTGCACACCACTCCTAAGGCC
GTAGAGAAGGAGCTGAACGCCCTCTACGATGTGTTTCTGGAGGTCTCCCAGCACTGGCAGAGCAAGGACGTGATCCTGCTTGGGGACTTC
AATGCTGACTGCGCTTCACTGACCAAAAAGCGCCTGGACAAGCTGGAGCTGCGGACTGAGCCAGGCTTCCACTGGGTGATTGCCGATGGG
GAGGACACCACAGTGCGGGCCAGCACCCACTGCACCTATGACCGCGTCGTGCTGCACGGGGAGCGCTGCCGGAGTCTGCTGCACACTGCG
GCTGCCTTTGACTTCCCCACGAGCTTCCAGCTCACCGAGGAGGAGGCCCTCAACATCAGTGACCACTACCCCGTGGAGGTGGAGCTGAAG
CTGAGCCAGGCGCACAGCGTCCAGCCTCTCAGCCTCACTGTTCTGTTGCTGCTATCACTCCTGTCCCCTCAGCTGTGCCCTGCTGCCTGA
GCGTCCCCCTACCCCCCCAGGGCCTGCTGCCTTTTGGGACTTAAACCCCAGCCTCCCCCGTCCATCCAGCCCTGGGGCTGGGGGGCTTCA
ACTATAGTTGCCCTGTGACTGTAGTCCACCCCTGCCTGCCTTGTTTGATTTGGCTCTTGTTCTTTGGTTGGGCTTGTGCCTAGATTAGGA
GAGGAAGCCAGGGGCCCTGCACTCATGCCACCTGCCAGGTAGTGTAGTATCAGGAGTGGAGACAAAGTGGGCTCTGGGTTGGGGTAGGGG
AAGGGAGGGTTCAGAAAGAGGAATGAAGATGTTGTATGACAAGAAGGAAAGTTACTGAGAACAAAAACCCAGATTGGTGAGATAGGACAC
TTGTGCAGCAGATATGCCAATGGGCCATGTTTATTGTGGATTGGTAAGAATCACCAGGAAACCATTAAGCCCCAATAGCTACAAGGAGGG
TGGTTAATCTGCTATATCAAACTCCTTCCCTGAAACCAGCAAACACCGGGAAACATTTTGGCTCATTATAATCCGGTGAACAATGCAGTC
AGGCCTGTTATAACCGCTGAGCAGCCACACTCGCACCTCCTGGGTGCTGTAGTCTGTGTTGGTACAGGCTTCTGCATGCCTGGTAAAGTC
CAGCCAAGGCTGGTCAAGGCAACATCTCCACACAGAAAATCTGCACCAGTTATGTAAGCTAAAAAGCTGTGTGAACCCAGGTGTCCCGGA
AAGGGGCTGCAGGACACAGCAAAATGCCAGCAGCGTGCCGGACCCCTCCCTTCCATCCTCCTCTCCAAAGAACAGAGGTCAGGAAAAACA
CTGGCTGGGACGCTAGAAGGGTCATGTGTTAACTATAATCACATTTATGGTTTGGAACCATCACCCCAAGGTAAAAAAAAAATAAAAGGT
ATTCCCAGGTATGTTTGGCAAAATAAAATAAAGGTAATTAAAAACCTAAGAAATGGCTGTAAACTGAGATTACAAAAAACCAGAGGCCTT
TTGGGAGCCACAGGCTGGGGGCTGGGGCCAACATACCCCAGCTCTGGGACCAAAAGCCTTTGGAGTCCTGTCCCTGGATACAGATGCTCA
GGCCACCCACCTAGCACTCCTCTCATTTTTGCTGCTCCCCCAAAAGCCAGCGCTGTTCTACAATAGTTCAGGTCAGACATCTAAGATCCC
CAGGCCAAACCATGCCACACACGTGTCTGTTCCGAGGTCTTGTTACAAATGACCAAAGGTTAGCCTAGACCTTTGGTCAGGTGGTGAAGG
CCCTGGGAATGCAGGTTCTAGAAGGGGTGGGGGCATGGGGCCCAGGAGGTTGCTAGAGATAGGAAATGGGGCAAATCGCAGGTGACCTCA
GCAGTACCTGGATGATTCCCACCAAGGAGGAATGGCCAAACCAGATGGGTGAGAACAAGCCCAATGTGATGCACACCTACCCTTGCTAAA

>52521_52521_4_MECP2-DNASE1L1_MECP2_chrX_153357642_ENST00000407218_DNASE1L1_chrX_153631963_ENST00000393638_length(amino acids)=207AA_BP=8
MVAGMLGLRSHKTQVLSSYVYNDEDDVFAREPFVAQFSLPSNVLPSLVLVPLHTTPKAVEKELNALYDVFLEVSQHWQSKDVILLGDFNA
DCASLTKKRLDKLELRTEPGFHWVIADGEDTTVRASTHCTYDRVVLHGERCRSLLHTAAAFDFPTSFQLTEEEALNISDHYPVEVELKLS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MECP2-DNASE1L1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	MECP2	chrX:153357642	chrX:153631963	ENST00000303391	-	2	4	269_309	8.666666666666666	487.0	NCOR2
Hgene	MECP2	chrX:153357642	chrX:153631963	ENST00000453960	-	1	3	269_309	0	499.0	NCOR2
Hgene	MECP2	chrX:153357642	chrX:153631963	ENST00000303391	-	2	4	285_309	8.666666666666666	487.0	TBL1XR1
Hgene	MECP2	chrX:153357642	chrX:153631963	ENST00000453960	-	1	3	285_309	0	499.0	TBL1XR1

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for MECP2-DNASE1L1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for MECP2-DNASE1L1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source