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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:MED12L-GMPS (FusionGDB2 ID:52537) |
Fusion Gene Summary for MED12L-GMPS |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MED12L-GMPS | Fusion gene ID: 52537 | Hgene | Tgene | Gene symbol | MED12L | GMPS | Gene ID | 116931 | 8833 |
| Gene name | mediator complex subunit 12L | guanine monophosphate synthase | |
| Synonyms | NOPAR|TNRC11L|TRALP|TRALPUSH | GATD7 | |
| Cytomap | 3q25.1 | 3q25.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mediator of RNA polymerase II transcription subunit 12-like proteinmediator complex subunit 12 likemediator of RNA polymerase II transcription, subunit 12 homolog-likeno opposite paired repeat proteinthyroid hormone receptor-associated-like proteintr | GMP synthase [glutamine-hydrolyzing]GMP synthaseGMP synthetaseMLL/GMPS fusion proteinglutamine amidotransferaseguanine monophosphate synthetaseguanosine 5'-monophosphate synthasetesticular tissue protein Li 82 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q86YW9 | P49915 | |
| Ensembl transtripts involved in fusion gene | ENST00000474524, ENST00000273432, ENST00000309237, ENST00000422248, ENST00000491549, | ENST00000295920, ENST00000476145, ENST00000496455, | |
| Fusion gene scores | * DoF score | 9 X 9 X 5=405 | 8 X 7 X 6=336 |
| # samples | 9 | 11 | |
| ** MAII score | log2(9/405*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/336*10)=-1.6109577092541 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MED12L [Title/Abstract] AND GMPS [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | MED12L(151134210)-GMPS(155611306), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | GMPS | GO:0006177 | GMP biosynthetic process | 8089153 |
| Fusion gene breakpoints across MED12L (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across GMPS (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | STAD | TCGA-BR-A4IU | MED12L | chr3 | 151134210 | + | GMPS | chr3 | 155611306 | + |
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Fusion Gene ORF analysis for MED12L-GMPS |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000474524 | ENST00000295920 | MED12L | chr3 | 151134210 | + | GMPS | chr3 | 155611306 | + |
| 5CDS-intron | ENST00000474524 | ENST00000476145 | MED12L | chr3 | 151134210 | + | GMPS | chr3 | 155611306 | + |
| In-frame | ENST00000474524 | ENST00000496455 | MED12L | chr3 | 151134210 | + | GMPS | chr3 | 155611306 | + |
| intron-3CDS | ENST00000273432 | ENST00000496455 | MED12L | chr3 | 151134210 | + | GMPS | chr3 | 155611306 | + |
| intron-3CDS | ENST00000309237 | ENST00000496455 | MED12L | chr3 | 151134210 | + | GMPS | chr3 | 155611306 | + |
| intron-3CDS | ENST00000422248 | ENST00000496455 | MED12L | chr3 | 151134210 | + | GMPS | chr3 | 155611306 | + |
| intron-3CDS | ENST00000491549 | ENST00000496455 | MED12L | chr3 | 151134210 | + | GMPS | chr3 | 155611306 | + |
| intron-intron | ENST00000273432 | ENST00000295920 | MED12L | chr3 | 151134210 | + | GMPS | chr3 | 155611306 | + |
| intron-intron | ENST00000273432 | ENST00000476145 | MED12L | chr3 | 151134210 | + | GMPS | chr3 | 155611306 | + |
| intron-intron | ENST00000309237 | ENST00000295920 | MED12L | chr3 | 151134210 | + | GMPS | chr3 | 155611306 | + |
| intron-intron | ENST00000309237 | ENST00000476145 | MED12L | chr3 | 151134210 | + | GMPS | chr3 | 155611306 | + |
| intron-intron | ENST00000422248 | ENST00000295920 | MED12L | chr3 | 151134210 | + | GMPS | chr3 | 155611306 | + |
| intron-intron | ENST00000422248 | ENST00000476145 | MED12L | chr3 | 151134210 | + | GMPS | chr3 | 155611306 | + |
| intron-intron | ENST00000491549 | ENST00000295920 | MED12L | chr3 | 151134210 | + | GMPS | chr3 | 155611306 | + |
| intron-intron | ENST00000491549 | ENST00000476145 | MED12L | chr3 | 151134210 | + | GMPS | chr3 | 155611306 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000474524 | MED12L | chr3 | 151134210 | + | ENST00000496455 | GMPS | chr3 | 155611306 | + | 14730 | 6341 | 38 | 8395 | 2785 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000474524 | ENST00000496455 | MED12L | chr3 | 151134210 | + | GMPS | chr3 | 155611306 | + | 0.000339549 | 0.9996605 |
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Fusion Genomic Features for MED12L-GMPS |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for MED12L-GMPS |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:151134210/chr3:155611306) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MED12L | GMPS |
| FUNCTION: May be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). {ECO:0000250}. | FUNCTION: Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | GMPS | chr3:151134210 | chr3:155611306 | ENST00000496455 | 0 | 16 | 217_435 | 9 | 694.0 | Domain | GMPS ATP-PPase | |
| Tgene | GMPS | chr3:151134210 | chr3:155611306 | ENST00000496455 | 0 | 16 | 27_216 | 9 | 694.0 | Domain | Glutamine amidotransferase type-1 | |
| Tgene | GMPS | chr3:151134210 | chr3:155611306 | ENST00000496455 | 0 | 16 | 244_250 | 9 | 694.0 | Nucleotide binding | ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MED12L | chr3:151134210 | chr3:155611306 | ENST00000309237 | + | 1 | 15 | 1877_2134 | 0 | 757.0 | Compositional bias | Note=Gln-rich |
| Hgene | MED12L | chr3:151134210 | chr3:155611306 | ENST00000422248 | + | 1 | 14 | 1877_2134 | 0 | 722.0 | Compositional bias | Note=Gln-rich |
| Hgene | MED12L | chr3:151134210 | chr3:155611306 | ENST00000474524 | + | 41 | 43 | 1877_2134 | 2101 | 2146.0 | Compositional bias | Note=Gln-rich |
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Fusion Gene Sequence for MED12L-GMPS |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >52537_52537_1_MED12L-GMPS_MED12L_chr3_151134210_ENST00000474524_GMPS_chr3_155611306_ENST00000496455_length(transcript)=14730nt_BP=6341nt CCAACTCTCATTCATTTCGCCGGTTAACATGAGAGATCATGGCCGCCTTCGGGCTTCTCAGCTATGAGCAGAGACCGCTGAAGCGCCCCC GGCTCGGGCCGCCCGACGTCTACCCACAGGACCCCAAGCAGAAGGAGGATGAACTTACTGCTGTGAATGTAAAGCAAGGCTTCAATAATC AGCCAGCCTTCACTGGAGATGAACATGGCTCAGCCAGAAATATTGTAATTAACCCATCAAAGATTGGAGCTTATTTTAGCAGCATATTAG CTGAGAAACTGAAGCTTAACACTTTCCAGGACACGGGAAAGAAGAAACCACAAGTTAATGCTAAAGATAATTATTGGCTGGTTACTGCTC GATCCCAGAGTGCAATTCATAGTTGGTTTTCTGACTTAGCAGGAAATAAGCCACTTTCTATTTTGGCAAAAAAGGTTCCTATCCTTAGTA AAAAAGAGGATGTTTTTGCATATTTAGCTAAATATTCTGTGCCAATGGTTCGAGCAACGTGGCTGATCAAGATGACTTGTGCCTATTATT CTGCTATATCTGAAGCTAAAATTAAGAAACGTCAGGCTCCTGATCCGAATTTGGAGTGGACACAGATATCTACCAGATATCTTCGAGAGC AGTTGGCCAAGATTTCTGACTTTTACCACATGGCCTCCAGCACGGGCGATGGCCCTGTCCCTGTGCCACCAGAGGTGGAGCAAGCCATGA AGCAATGGGAATACAACGAAAAGCTAGCATTTCACATGTTCCAGGAAGGAATGTTAGAAAAACACGAATATTTGACATGGATCCTGGATG TTTTAGAAAAGATCAGACCAATGGATGATGATCTTCTTAAACTCTTGCTACCACTAATGCTGCAGTATTCAGATGAGTTTGTTCAGTCGG CCTACCTGTCTCGTCGTCTTGCCTACTTTTGTGCCCGGCGTCTTTCCTTGCTGCTGAGCGATAGCCCCAACCTCCTTGCTGCCCACTCAC CCCACATGATGATAGGACCAAACAACTCGAGTATCGGGGCCCCCAGCCCTGGCCCCCCCGGCCCTGGCATGAGCCCCGTGCAGCTGGCCT TCTCAGATTTTCTTTCCTGTGCACAGCATGGTCCCCTGGTTTATGGACTTAGTTGTATGTTGCAGACTGTCACTCTCTGTTGCCCAAGTG CCTTGGTGTGGAATTATTCCACAAATGAAAATAAGAGCGCAAACCCAGGCTCACCCCTGGATCTGCTGCAGGTGGCCCCGTCCAGCCTCC CCATGCCGGGTGGGAACACGGCTTTCAATCAGCAGGTTCGGGCAAGGATTTATGAAGTAGAACAACAGATAAAACAAAGAGGCCGTGCAG TGGAAGTTCGGTGGTCATTTGACAAGTGCCAAGAATCCACAGCAGGGGTGACTATTAGTCGGGTTTTGCACACGTTGGAAGTTTTGGATC GTCACTGTTTTGACCGAACTGATTCCAGCAATTCCATGGAGACACTTTATCATAAGATTTTCTGGGCAAACCAAAACAAAGATAACCAAG AGGTTGCGCCCAACGATGAAGCTGTGGTGACGCTGTTATGTGAATGGGCCGTGAGCTGCAAACGGTCTGGCAAGCACAGGGCCATGGCTG TGGCAAAACTCCTGGAGAAGAGGCAAGCAGAAATTGAGGCAGAGAGATGTGGTGAATCAGAAGTCTTAGATGAGAAGGAGTCTATTTCTT CATCCTCTCTTGCTGGATCCAGTTTGCCTGTTTTCCAGAATGTGCTGTTAAGGTTTTTAGATACACAGGCCCCCTCTTTGTCGGACCCAA ACAGTGAATGTGAAAAGGTGGAATTTGTGAACCTGGTGCTGCTCTTCTGCGAGTTCATCCGCCATGATGTCTTCTCCCATGACGCATACA TGTGTACCCTCATATCTCGAGGAGATTTGTCAGTCACTGCCTCAACTCGGCCGCGGTCACCAGTAGGGGAAAATGCAGATGAACACTATT CAAAGGACCATGATGTGAAAATGGAGATTTTTTCTCCTATGCCTGGAGAATCCTGTGAGAATGCCAACACTTCGTTGGGCAGAAGAATGT CAGTTAATTGTGAGAAGTTGGTGAAGAGGGAAAAGCCAAGGGAATTAATTTTTCCATCTAATTATGACCTCCTTCGCCACTTACAGTATG CAACACATTTTCCTATACCTCTGGATGAATCTTCAAGTCATGAATGTAACCAGCGCACAATCCTTCTCTATGGAGTCGGCAAAGAGCGTG ATGAAGCAAGGCATCAGCTGAAGAAGATTACCAAAGATATCCTGAAAATTCTAAATAAGAAGAGCACCACAGAGACAGGGGTTGGGGACG AAGGACAAAAAGCCAGGAAGAACAAACAGGAGACATTTCCAACACTGGAGACTGTGTTCACTAAACTCCAGCTCCTTTCATATTTTGATC AACATCAAGTGACATCTCAGATTTCTAACAATGTGCTAGAACAAATCACAAGCTTTGCGTCAGGAACATCCTATCATCTCCCTTTGGCTC ACCACATTCAGCTCATCTTTGATCTCATGGAGCCAGCACTGAACATCAACGGACTAATTGACTTCGCAATACAGTTACTAAATGAACTGA GTGTTGTGGAAGCTGAACTGCTCCTAAAATCCTCCAGCCTGGCAGGAAGTTATACAACAGGACTGTGTGTCTGCATCGTGGCTGTTCTCA GGCGCTATCACAGTTGTCTAATCTTGAATCCTGATCAGACAGCCCAGGTGTTTGAAGGGTTGTGTGGTGTGGTCAAGCATGTCGTAAACC CCTCAGAATGTTCTTCCCCTGAAAGATGCATTTTAGCCTACCTCTATGATCTCTATGTGTCATGTAGCCACCTCAGAAGTAAATTTGGAG ACCTCTTCAGTAGTGCCTGTTCAAAAGTAAAGCAAACCATATATAATAACGTGATGCCTGCAAATTCGAACTTGCGATGGGATCCAGACT TCATGATGGATTTTATTGAGAATCCCTCAGCCCGCAGCATCAACTACTCAATGCTGGGCAAGATCCTCAGTGACAATGCGGCCAATCGCT ACAGCTTTGTCTGCAATACACTCATGAATGTATGTATGGGCCATCAGGATGCTGGCAGGATTAACGACATAGCCAATTTCTCCTCTGAGC TTACGGCTTGCTGCACTGTTCTTAGTTCAGAATGGCTGGGGGTTCTGAAGGCTCTTTGTTGTTCTTCAAATCACGTGTGGGGGTTTAATG ATGTACTTTGCACTGTAGATGTGAGTGACCTTTCATTCCATGATTCATTAGCTACTTTCATTGCTATTCTGATAGCACGACAGTGTTTTT CCCTGGAGGACGTCGTGCAGCATGTCGCACTTCCCTCTCTTCTAGCAGCAGCTTGTGGGGATGCGGACGCCGAGCCTGGGGCGAGAATGA CATGCCGACTCTTGCTTCATCTCTTCCGAGCTCCCCAGGCCTGCTTCTTACCTCAAGCAACGGGCAAACCTTTCCCTGGAATAAGATCAT CTTGTGATAGACACCTCTTAGCCGCTGCTCACAACAGCATTGAAGTGGGAGCCGTGTTTGCTGTCTTAAAAGCAATTATGATGCTTGGAG ATGCCAAAATTGGCAATAACAGTGTCAGCTCTTTAAAGAATGATGACTTCACCATGAGAGGTTTGCGATGTGATGGGAATGCTGATGATA TCTGGACTGCCTCACAAAATCCAAAATCCTGTGGGAAAAGCATTTCCATAGAAACTGCCAATTTAAGAGAATACGCTAGATATGTACTGA GGACTATCTGTCAACAGGAATGGGTAGGAGAGCATTGCTTAAAAGAACCTGAAAGATTATGTACAGACAAAGAACTTATATTGGACCCTG TGCTTTCAAATATGCAAGCACAGAAATTACTGCAGCTTATCTGTTATCCTCATGGCATTAAAGAATGTACCGAGGGGGACAATCTGCAAA GACAGCACATTAAGCGTATTCTTCAGAATCTTGAGCAGTGGACACTGAGGCAATCCTGGTTAGAACTCCAGCTAATGATCAAACAGTGCT TGAAGGACCCTGGCTCTGGTTCTGTGGCCGAAATGAACAACTTACTGGACAATATTGCAAAGGCAACAATAGAGGTATTCCAGCAGTCTG CAGACCTAAATAATTCTTCTAATTCTGGCATGAGCCTCTTCAACCCAAACAGTATTGGAAGTGCTGATACAAGTAGCACGAGACAGAATG GAATAAAGACATTCCTAAGTTCCTCCGAACGCAGGGGTGTATGGTTGGTGGCCCCCCTCATCGCCAGGTTGCCAACTTCTGTGCAAGGAA GAGTGCTGAAAGCCGCTGGGGAAGAGCTGGAGAAGGGACAGCACTTGGGTTCTTCTTCCAAAAAGGAAAGGGACAGACAGAAACAGAAAA GTATGTCTCTTTTGAGTCAACAACCCTTCCTCTCACTGGTACTTACCTGCCTTAAGGGACAAGATGAACAAAGGGAAGGCCTCCTAACAT CTCTCCAGAATCAAGTTAACCAGATTTTAAGTAACTGGAGAGAAGAACGATACCAAGATGACATAAAAGCGCGGCAGATGATGCACGAAG CATTGCAACTCCGCCTAAATTTGGTAGGAGGAATGTTTGACACGGTGCAGAGGAGCACCCAGTGGACTACAGACTGGGCCCTGCTACTCC TTCAGATCATTACTTCAGGAACTGTTGACATGCACACTAACAATGAATTATTCACAACAGTTCTTGACATGCTGGGTGTTTTAATCAATG GAACGTTAGCCTCTGACCTATCAAATGCATCCCCTGGGGGATCTGAAGAGAACAAGCGTGCATACATGAATTTAGTAAAGAAACTGAAAA AAGAGCTAGGAGACAAGCGATCAGAAAGTATTGACAAAGTTCGACAGTTACTACCTTTGCCGAAACAGACATGTGATGTCATCACTTGTG AACCTATGGGTTCCTTGATTGACACAAAAGGAAACAAAATTGCTGGATTTGACTCTATAGATAAAAAACAGGGTCTCCAGGTCTCTACGA AGCAGAAGGTGTCCCCGTGGGACTTGTTTGAGGGTCAGAAGAACCCAGCTCCTTTGTCCTGGGCCTGGTTTGGGACAGTCCGAGTGGACC GAAGAGTGATCAAGTACGAGGAGCAGCATCACCTCCTGCTGTATCACACACACCCCATGCCCAAGCCCCGCAGTTACTACCTCCAGCCAC TGCCCCTGCCTCCTGAGGAGGAAGAGGAAGAGCCCACATCTCCAGTTTCTCAGGAACCAGAAAGGAAGTCCGCTGAGCTGTCAGATCAGG GAAAAACCACAACAGATGAAGAAAAGAAAACAAAAGGAAGGAAGCGCAAGACGAAATCTAGCTCAAGAGTTGATGAATATCCACAGAGCA ACATATACCGAGTGCCTCCTAATTACTCGCCTATCTCCTCCCAAATGATGCACCATCCACAGTCCACCTTGTGGGGTTACAACCTCGTGG GCCAGCCCCAGCAGCCCGGCTTTTTCCTTCAGAACCAATCTCTTACTCCAGGTGGCTCCAGATTGGACCCTGCAGGCTCCTTTGTCCCAA CCAACACCAAACAAGCTCTGTCAAACATGCTACAGCGGCGCTCAGGCGCCATGATGCAGCCGCCTTCTCTTCATGCAATCACATCGCAGC AGCAGTTGATACAGATGAAGCTTCTGCAGCAGCAGCAGCAACAGCGACTTCTCAGGCAAGCCCAGACTCGGCCTTTCCAACAGGGCCAGC CGGGGGACCAGGCTGCTCTCTTTGCTGCGCAAGCACGGCCCTCCCCTCAGCTCCCTCAGTATCCAGGGCTGCAGCAAGCACAGACCATGC CACAGGGCTATACAATGTATGGGACACAGATGCCTTTGCAGCAGACATCGCAGCAGCAGGCTGGCAGTGTGGTCCTGTCTCCCAGCTATA ACTCCAGAGCCTATCCGGCCGCACATTCCAACCCCGTGCTAATGGAAAGACTCAGACAGATTCAGCAGCAGCCGAGTGGCTATGTTCAGC AGCAGGCCTCGCCGTACCTGCAGCCCCTGACTGGCTCTCAGAGACTGAACCATCAGGCTCTACAGCAGAGCCCTCTGGTGGGCGGGGGAA TTGATGCTGTGCTGACTTCTGCACATCCAAACCTTCCCTCCGTGCCCCTGCCTCAGGATCCCATGAGACCCAGACAGCCGCAAGTTCGAC AGCAGCAGAGACTCCTCCAGATGCAGCAGCCCCAGCAGCCCCAGCCCCAGCAGCCTCCCCAGCCCCAGCAGTCCTCGCAGTCCCAGAGTC AGACCCTTGGTCTCCAAGCAATGCAGCCCCAGCAGCCCTTGCTGGAGAATGCTGGAGGAGACCTTAAGGATGGCCACCACCACTATGAAG GAGCTGTTGTCATTCTGGATGCTGGTGCTCAGTACGGGAAAGTCATAGACCGAAGAGTGAGGGAACTGTTCGTGCAGTCTGAAATTTTCC CCTTGGAAACACCAGCATTTGCTATAAAGGAACAAGGATTCCGTGCTATTATCATCTCTGGAGGACCTAATTCTGTGTATGCTGAAGATG CTCCCTGGTTTGATCCAGCAATATTCACTATTGGCAAGCCTGTTCTTGGAATTTGCTATGGTATGCAGATGATGAATAAGGTATTTGGAG GTACTGTGCACAAAAAAAGTGTCAGAGAAGATGGAGTTTTCAACATTAGTGTGGATAATACATGTTCATTATTCAGGGGCCTTCAGAAGG AAGAAGTTGTTTTGCTTACACATGGAGATAGTGTAGACAAAGTAGCTGATGGATTCAAGGTTGTGGCACGTTCTGGAAACATAGTAGCAG GCATAGCAAATGAATCTAAAAAGTTATATGGAGCACAGTTCCACCCTGAAGTTGGCCTTACAGAAAATGGAAAAGTAATACTGAAGAATT TCCTTTATGATATAGCTGGATGCAGTGGAACCTTCACCGTGCAGAACAGAGAACTTGAGTGTATTCGAGAGATCAAAGAGAGAGTAGGCA CGTCAAAAGTTTTGGTTTTACTCAGTGGTGGAGTAGACTCAACAGTTTGTACAGCTTTGCTAAATCGTGCTTTGAACCAAGAACAAGTCA TTGCTGTGCACATTGATAATGGCTTTATGAGAAAACGAGAAAGCCAGTCTGTTGAAGAGGCCCTCAAAAAGCTTGGAATTCAGGTCAAAG TGATAAATGCTGCTCATTCTTTCTACAATGGAACAACAACCCTACCAATATCAGATGAAGATAGAACCCCACGGAAAAGAATTAGCAAAA CGTTAAATATGACCACAAGTCCTGAAGAGAAAAGAAAAATCATTGGGGATACTTTTGTTAAGATTGCCAATGAAGTAATTGGAGAAATGA ACTTGAAACCAGAGGAGGTTTTCCTTGCCCAAGGTACTTTACGGCCTGATCTAATTGAAAGTGCATCCCTTGTTGCAAGTGGCAAAGCTG AACTCATCAAAACCCATCACAATGACACAGAGCTCATCAGAAAGTTGAGAGAGGAGGGAAAAGTAATAGAACCTCTGAAAGATTTTCATA AAGATGAAGTGAGAATTTTGGGCAGAGAACTTGGACTTCCAGAAGAGTTAGTTTCCAGGCATCCATTTCCAGGTCCTGGCCTGGCAATCA GAGTAATATGTGCTGAAGAACCTTATATTTGTAAGGACTTTCCTGAAACCAACAATATTTTGAAAATAGTAGCTGATTTTTCTGCAAGTG TTAAAAAGCCACATACCCTATTACAGAGAGTCAAAGCCTGCACAACAGAAGAGGATCAGGAGAAGCTGATGCAAATTACCAGTCTGCATT CACTGAATGCCTTCTTGCTGCCAATTAAAACTGTAGGTGTGCAGGGTGACTGTCGTTCCTACAGTTACGTGTGTGGAATCTCCAGTAAAG ATGAACCTGACTGGGAATCACTTATTTTTCTGGCTAGGCTTATACCTCGCATGTGTCACAACGTTAACAGAGTTGTTTATATATTTGGCC CACCAGTTAAAGAACCTCCTACAGATGTTACTCCCACTTTCTTGACAACAGGGGTGCTCAGTACTTTACGCCAAGCTGATTTTGAGGCCC ATAACATTCTCAGGGAGTCTGGGTATGCTGGGAAAATCAGCCAGATGCCGGTGATTTTGACACCATTACATTTTGATCGGGACCCACTTC AAAAGCAGCCTTCATGCCAGAGATCTGTGGTTATTCGAACCTTTATTACTAGTGACTTCATGACTGGTATACCTGCAACACCTGGCAATG AGATCCCTGTAGAGGTGGTATTAAAGATGGTCACTGAGATTAAGAAGATTCCTGGTATTTCTCGAATTATGTATGACTTAACATCAAAGC CCCCAGGAACTACTGAGTGGGAGTAATAAACTTCTTGTTCTATTAAAGTACCGTGTGCAGTTTAAATTGATTAGAAATCATTCCCATTAT TGACATGCAGTACTGTGAAAAGAGTTACTGGAGCAGCTACATCACATCTGAGTTCTCCACAGCAAAAATCTACGGCTTAAGAGCTGAGTT GGGGATAACCAAAAGGGACTGAAGAGTTTGTACGGGTAAATAATCAAAGCACCATTGCCTACACTCAGACAGATTGATACTGCTTTTGCC TTTGCCTCACTTATTCTTTATGTATAAATTCACTGTTGATGTCTCTGTGAATATGTATGAAGGTGGGTGAATTTGGGGGTAATTATGGGC TTCTGTCTCCTTACCAGTTTCTAAGAACTGTTAGAAACGCCCATTATTTACCAGTGTTACTTACTACTTATATATACTTTTTGGAGAATC AGTTTTCTTATAAGTAATCTTATTTCTCCAAAGGGTGAAAAAGAGATGAACATATCAGATAAAGGTATAGGTGGGCTATTCCAGCCACTT TTGAAGGACACTGAGGGTATAAAATGTAAGCTACCATAAGATGGAAAAGCACCAGGAATTTGTTGATGTACTTTTGAATTTTATTTCACA GCCTTGGGAGGAAGAAACTATGAGTGGTCTCAGATGTCTATGAATGGTCTTAAAATGTTTTCAAACCATGTTCCACATAGATGCCATGTT ATTCAATGTCAGCTTGTTTATTAGTAAGGAGCTTTATCCTCCTAGCCTTATATTACCAGCCCCCCACAGCCTTGCATAGAAAGTTTCTGT TATCTCCTTAGAAGAAACTGGCTCAATGACGTTTCTGGTGTAGTGCAGATAGAGGTCAAGAGGAGCATTTTCATCTCTTCTTTTGCTGGT CAGAGAAACGGTTCTGAGATCACAGAAGCTATGATGCATACCTACAGCTTACAAAAGGGAGAGGAAAAATGTTTATATCATCTAGTAAAC AGTTGTAAAATGAGCTTTTAAATCTAATCTATAGACATATTATTCATTGCTCAGACACCTGTGAACAGTCTTGATACATGCAAGATGTTT GCCAAACTTTGTAATCCTTTCTACTAGCTATAAGAGAGGATTTAAGAACTGGTGTAGGACTTGTTGCCATCACCACCAGTTTCTAACAGA TCTTTTATAACATTCACATAAGTACTGTAGACAGTAGTAGACTTAAACTCTCCGTTTCTCTCAGTATTTTAGCTAAGAATGTTACCATAT TTTTCTCTTAACAATTCCATCTCAGGTTGCTGCTGCTTGTCTAGTTTAAAAGGTCAGATCTATTAATCAGGAATGAAATTTTATTTGGGA TTCAGTGTTAGACAAACAACAAAATGATGCGTGGCAGAAGTCATCTTTTTATTCTGGCTGGTCCAGGGAACAAGAAAACTGCTGCTGGAC CAGCAAGGGAAGAGTTTCTGTCTGTCTTAACAGAAATCTGTCCCCAAGACAAAGGGGTACTTGACTCCTACAAAACTTAAAGGGTACATT CTCTATCTGATGAGGAGGTACTCATTATGGCCTTCTGGAAAGAGGCTATGTTAGTGATCTGGTCTTTACAGATTTAGAGTCATGTTATTT GAAAGCTAGAATAGACAACCTATAAAATGCTTACCAACATGTGTCAGTACACGTTTATGTTTATATGAAAAAAAATTTCTAGCCACAGTG TCTTATGATTTTGTATTGAAGCAAACAGTAGGAATTTTGGAAAAATAGAGAGTAAGAATGTGTGTTCTATGGAACACTGCTCCACTGAGA AGGTCCATGTAAAAAGGATTAGGTGGTCATATAAGTTTGGGGAACATAAGCTCACTTGTCCTTTCCTGGAGATTCATGGTATATAATATT CAAAGCTCTGAGAAATTCTGAAGTTAAAAACAATTGTTAAATTCTGCTTAAATTAGTGTTTTCCTGATATTTGTTTTTTGAACACCTTTT ATATAATCCCTTCTAATATATACTTAGTATATACTTAATATAATATTGGGAAAATTGTTACTCCAAAGCACATCTTGACATGACATAGTT TCTTAAAAATCCAAATTTTCTGGAACTCAGAAATTTCCTAATATTTAGCACACTGTCTTCTTTTGCACAGCACTTTTTGCTTTGTGCCAT ATAGCATTACTCTGTACCTTCACAGTATTTCATCTGAGCCACTGAGGAAAGTTAAAGGTTGCACTTCCATTTTACAGTTAAGAAAACAAG CTCACCTTAGGCATGGTTACTTAATTAATTTCAGAATTAAATTTCAGGTTTCCTTAGTCCAGATTGTCCTGATGTGTATTCTGACACCTA AAATTATATAAACATTTATGGGATGCTTATTTTACTAAGACTAGAATGGTGGCTACCTGGCTAATAACATTCATCATTGGTTATTCTGGG CATATCATGACTTTATTCCCGTTGCTTACCATCTACCTGGGACACATCTCTCTTTGATTAAATATATTCTTTTTCTTTGTACTTTTTAGG TAGACAGAGAATGTAGATCATTGAAAGCATTATTTATTCCTAAGATTGGCAGGCACAGAATCATTTTTAAGAACCAAATACCCAGTCCTG CCTTAAAGGCCACATCTATGATCATCAGCTCTGTTAGAAATAACAGCCTGGCATAATTCCTAAATACAAGTCTGTAGATATATCCAGGAG ATAGGGTTACACTGTTTTCTAACCTTTTTTAAATCCCTTAATCTTGAGGTAAACTGCATGCATTTAGTCAAACAAGCATCATAAAATTTG TTTCCTCACTGTTTGGGCTTAACCTCCTGATAGCCTGTTTTACTGAATAACTTGACCCTAACCTGTAGAGAATAAGAGCATTCAAATTAG GAAGGCAGGACTATCCATCTTTAGTGCTTTTCCTGCCGTTAAACAACAATGTGAACTTGGTCAAGTCATTTCTGTTCTTTATCTGTGACA TGAGGTAACTGTATTAAATTTTCAGCATCAAATCCAGCTATAAATTTGTATTTTGTAAACAAGAGAAAGTAAAGCAGGAGACAGAATGGA GAAGCTGGATAGTGTTTTTTTTTTTTTTTTTTAAGGTTCTTTTATCATCAGATATGACACAAAGGGAAACATCAAAATGCACCGTAAAGT TAAATCCTAGTTACCTTTTTTTGAAGCTGTTGGCAAGGTTTGACCACTTGGGGCATCTTCTGCTGTGAGATGACACTTGAAAAACACCCA TCAAAGTTTTCCTGGTAGGAATCTCTCTTTACTGCGTGTTTTTTTGAAAAGCTGACAGAGAATATGCTTTGGCTTTGACACTAATGAAGT CACCCATCATCAATTACATACAGCTAATTGTTGGGAGCTAGAGCTAGAATCCAAGCTTTCTGATTCTCTGCATGGAAGAGGAAATGCTCT AGGGCCCTTCAGGGCAAATCTTAAAAGGAAGTTCTTGGCCGGGCGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTG GGTGGATCACGAGATCAGGAGATCGAGACCATCTTGGCTAACACGGTGAAACCCCATCTCTACTAAAAATACAACAAATTAGCTGGGCGC GGTGGCGGGTGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCCTGAACCCAGGAGGCGGAGCTTGCAGTGAGCTGAGA TAGTGCCACTGCACTCCGGCCTGGTGAAAGAGCGAGACTCAGTCTCAAAAAAAAAAAAAAAAGGAAGTTCTTAGTGTGTAATTGACCATC AGGGATAAATGGGCTTCAAAAGTGTTAATTGTCTCCTTACTTACAGTGAGTTTCTAGAGATAGCCCTGTCTTTCAGAAATTCTCTGACAT CTGCTTGCGCAATGTTATAACCACTTTCCCACACTACTCCCCTCCAGAAATCTCATTGATATGTGGCGAGGACACGCCTTAGCTATCACC CCAATGGATGCTTCTTTCATTGACCCAAATCCAGAATGTAATGGGGAACTGAATACAAGTTGGATGTCTCCACCCTTGGAAAGCACATCT TTTGTTCTTACTGAAGTAGTTTAACACCACCAGATGATCAAGGGATCAGGGTATCTTTCTGGTATCTTTTTAATCACTGAAGGACTTTGA CAGCAGTAATGGTGGCATTGTTGACTCTTAAATTTCTGAACGTTTCACTTAATGGCAAGTGAAGAGATATAGAATCCCCCAAAGAGTGTC AAGATGCTAACTTCCAACCCTATTTTTATGTACTGAAGAGGCCTCAGTGTCTCACTGAACTCTAACCTTTTTGTCAGTGTTCCTCAACAC TGGATGCGTATTATTACATAACCTGAGGAGTTAAAAAATACAATAACCAGATGTCCAATTAAATAAAATTAGAATCTGGAGGAGGTAGAA CTCAAGCATTTACAGTTTTGTTTTGTTTTTTTTTTAAGACAGAGTCTCGCTCTGTCCCCAAGTGCAGTGGCACAATCTCGGCTCACTGCA AGCTCCGCTTCGTGGGTTCACGCCATTCTCCTGCCTCAGTCTCCCGAGTAGCTGGGACTACAGGCGCCCGCCACTACGCCCGGCTAATTT TTTTGTACTTTTTAGTAGAGACAGGGTTTCACTGTGTTATACAGGATGGTCTCGATCTCCCGACCTCATGATCCGCCCGCCTCGGCCTCT CAGAGTGCTGGGATTACAGGCGTGAGCCACCACGCCCGGCAAGCATTTACAGTTTTAAATCTCCCAGTCAGAATAAATTCTTATTGAGGG CCATACCTAGCCTGTCTTCATCAAACTCATAGGTGAATCTTTGTCAAACCTATAGGAGAGAGATGCAGGCCATAGAGATGGTCTTGCTGA AGGTCTTATAGCTAAATTAGTTCAGATCCAGGAACCAGATTCTGGAACTGATTGCACCTATATTATGTTGTGTGTCAGACACTCCCAGGA CCTGTTTGGTAATAATTAGGACAGCTGACATACTTGTTGCTAATTTTGAGATCTGGGCAACAACTGTGTAGGCTGTTCTTTCAACCTCTT TCTTCTTACTTCTTTACTTTTCCTTCAGAGAGGAGAAAGCCACCCCTGTGCTATAGCCACCGCTCCAATTCTGACTCTAGCTAGGTCATG AAACAGACTGAGCTATTATTGCATCAACACATAAATCCTGTCATTTGGGTATTATTCTTTAGAGAACTAGAGATTACCTAGCTGCAACCT AAGTTTCCTGAATTAGAATCATTTGAGCAGCACCATCTTAATTGGCTCATTAACATATTTGTGACCAGGCACAGTGGCGCATGCCTGTAA TCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCTCTTGAGGTCAGGAGTTTGAGACCAGCGTGGCCAACATGGTGAAACCCCATTTCTA CTAAAAATGTAAAAATTAGCTGGGCTTGGTGGCGCGCGCCTGTAATCCCAGCTACTCGGAAGGCTGAGGTGTGAGAATCACTTAAACCCG GGAGATGGAGGTTGCAGTGAGCAGAGATTGCGCCACTGCACTCCAGCCTAGGTGACAAGAATGAGACTCCGTCTTAAAACAAAAACAACA TATTTGTTCACTTTTGAACCCTGTGGTGTCTTTTAACTTTGTTAAGGGCCCTTGGTTAGCAAAATTATGAAAGTTTAGGAAATTTGGCTA TTGAGTATATTAAGTACAACTACAAAATCCTCTGAGTTCTCCAGGAAGCCTAAACCTTGAGCAGTATCTTATTCAAGTGGAGTATATATC TTCAAGAATACAGATTTTTAAGGTAAGTAGTTTTTCGTCTTTGCATCTCCTAAGACCATTGTTAACAACCTTGATATTAAACGAAGAAGT GAATGTAAACCTCCTTTTGAACATATTTTTTATAAAGAAATATTTTGTTAATTGGAGTAAGTAGTATTGTTATGAAATCACTGTGTAATT GTTAATTGTAAACTGCAATGTCTATTTTGTGTTGTAACAATGTTGCCATAAAATAGCTTTGCTAAATGTGAAATGACTTTAATCCCTTTT GTCTTCAATATACTTCATAAAGGAGGAAATGATGATTTACACAATTTGTCATGAAGCTTCCGTGTTTATGAGAAATTCCAAGAAGTAAGA GCCAAGAGGACAGATATTATCAGAATATGGGACATAAGAAATTGCATATAGTGTCAAGGGTTTCTATATAACAACTTAATTTATTTCCCT TGCATATATAGTAGGGGTTAACATTTTGCTCAATGTTAACGGGGGACATAATGGACATAAAACATTGGATAGCTTTTTATTTAAATGAGC >52537_52537_1_MED12L-GMPS_MED12L_chr3_151134210_ENST00000474524_GMPS_chr3_155611306_ENST00000496455_length(amino acids)=2785AA_BP=2101 MAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTG KKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLSILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQA PDPNLEWTQISTRYLREQLAKISDFYHMASSTGDGPVPVPPEVEQAMKQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLL KLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLSLLLSDSPNLLAAHSPHMMIGPNNSSIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPL VYGLSCMLQTVTLCCPSALVWNYSTNENKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQES TAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIE AERCGESEVLDEKESISSSSLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVT ASTRPRSPVGENADEHYSKDHDVKMEIFSPMPGESCENANTSLGRRMSVNCEKLVKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSS HECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGVGDEGQKARKNKQETFPTLETVFTKLQLLSYFDQHQVTSQISNNVL EQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQ TAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARS INYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSF HDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFLPQATGKPFPGIRSSCDRHLLAAAHNS IEVGAVFAVLKAIMMLGDAKIGNNSVSSLKNDDFTMRGLRCDGNADDIWTASQNPKSCGKSISIETANLREYARYVLRTICQQEWVGEHC LKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMN NLLDNIAKATIEVFQQSADLNNSSNSGMSLFNPNSIGSADTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKG QHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMF DTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDK VRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRRVIKYEEQHHLL LYHTHPMPKPRSYYLQPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPIS SQMMHHPQSTLWGYNLVGQPQQPGFFLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMKLLQQQQ QQRLLRQAQTRPFQQGQPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTSQQQAGSVVLSPSYNSRAYPAAHSNPV LMERLRQIQQQPSGYVQQQASPYLQPLTGSQRLNHQALQQSPLVGGGIDAVLTSAHPNLPSVPLPQDPMRPRQPQVRQQQRLLQMQQPQQ PQPQQPPQPQQSSQSQSQTLGLQAMQPQQPLLENAGGDLKDGHHHYEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQG FRAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISVDNTCSLFRGLQKEEVVLLTHGDSVD KVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLTENGKVILKNFLYDIAGCSGTFTVQNRELECIREIKERVGTSKVLVLLSGGVD STVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEEALKKLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRK IIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGL PEELVSRHPFPGPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLMQITSLHSLNAFLLPIKTVG VQGDCRSYSYVCGISSKDEPDWESLIFLARLIPRMCHNVNRVVYIFGPPVKEPPTDVTPTFLTTGVLSTLRQADFEAHNILRESGYAGKI -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for MED12L-GMPS |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for MED12L-GMPS |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for MED12L-GMPS |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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