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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MED15-AHRR (FusionGDB2 ID:52605)

Fusion Gene Summary for MED15-AHRR

check button Fusion gene summary
Fusion gene informationFusion gene name: MED15-AHRR
Fusion gene ID: 52605
HgeneTgene
Gene symbol

MED15

AHRR

Gene ID

51586

57491

Gene namemediator complex subunit 15aryl-hydrocarbon receptor repressor
SynonymsARC105|CAG7A|CTG7A|PCQAP|TIG-1|TIG1|TNRC7AHH|AHHR|bHLHe77
Cytomap

22q11.21

5p15.33

Type of geneprotein-codingprotein-coding
Descriptionmediator of RNA polymerase II transcription subunit 15CTG repeat protein 7aPC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated proteinPC2 glutamine/Q-rich-associated proteinPC2-glutamine-rich-associated proteinTPA inducible gearyl hydrocarbon receptor repressorahR repressoraryl hydrocarbon hydroxylase regulatorclass E basic helix-loop-helix protein 77dioxin receptor repressor
Modification date2020031320200322
UniProtAcc

Q96RN5

A9YTQ3

Ensembl transtripts involved in fusion geneENST00000263205, ENST00000292733, 
ENST00000406969, ENST00000541476, 
ENST00000382974, ENST00000425759, 
ENST00000478831, ENST00000542773, 
ENST00000506456, ENST00000512529, 
ENST00000515206, ENST00000316418, 
ENST00000505113, 
Fusion gene scores* DoF score17 X 11 X 9=16837 X 6 X 4=168
# samples 209
** MAII scorelog2(20/1683*10)=-3.07296327155522
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/168*10)=-0.900464326449086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MED15 [Title/Abstract] AND AHRR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMED15(20909435)-AHRR(376725), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MED15 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AHRR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-D3-A1Q3-06AMED15chr22

20909435

-AHRRchr5

376725

+
ChimerDB4SKCMTCGA-D3-A1Q3-06AMED15chr22

20909435

+AHRRchr5

376725

+


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Fusion Gene ORF analysis for MED15-AHRR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000263205ENST00000506456MED15chr22

20909435

+AHRRchr5

376725

+
5CDS-intronENST00000263205ENST00000512529MED15chr22

20909435

+AHRRchr5

376725

+
5CDS-intronENST00000263205ENST00000515206MED15chr22

20909435

+AHRRchr5

376725

+
5CDS-intronENST00000292733ENST00000506456MED15chr22

20909435

+AHRRchr5

376725

+
5CDS-intronENST00000292733ENST00000512529MED15chr22

20909435

+AHRRchr5

376725

+
5CDS-intronENST00000292733ENST00000515206MED15chr22

20909435

+AHRRchr5

376725

+
5CDS-intronENST00000406969ENST00000506456MED15chr22

20909435

+AHRRchr5

376725

+
5CDS-intronENST00000406969ENST00000512529MED15chr22

20909435

+AHRRchr5

376725

+
5CDS-intronENST00000406969ENST00000515206MED15chr22

20909435

+AHRRchr5

376725

+
5CDS-intronENST00000541476ENST00000506456MED15chr22

20909435

+AHRRchr5

376725

+
5CDS-intronENST00000541476ENST00000512529MED15chr22

20909435

+AHRRchr5

376725

+
5CDS-intronENST00000541476ENST00000515206MED15chr22

20909435

+AHRRchr5

376725

+
In-frameENST00000263205ENST00000316418MED15chr22

20909435

+AHRRchr5

376725

+
In-frameENST00000263205ENST00000505113MED15chr22

20909435

+AHRRchr5

376725

+
In-frameENST00000292733ENST00000316418MED15chr22

20909435

+AHRRchr5

376725

+
In-frameENST00000292733ENST00000505113MED15chr22

20909435

+AHRRchr5

376725

+
In-frameENST00000406969ENST00000316418MED15chr22

20909435

+AHRRchr5

376725

+
In-frameENST00000406969ENST00000505113MED15chr22

20909435

+AHRRchr5

376725

+
In-frameENST00000541476ENST00000316418MED15chr22

20909435

+AHRRchr5

376725

+
In-frameENST00000541476ENST00000505113MED15chr22

20909435

+AHRRchr5

376725

+
intron-3CDSENST00000382974ENST00000316418MED15chr22

20909435

+AHRRchr5

376725

+
intron-3CDSENST00000382974ENST00000505113MED15chr22

20909435

+AHRRchr5

376725

+
intron-3CDSENST00000425759ENST00000316418MED15chr22

20909435

+AHRRchr5

376725

+
intron-3CDSENST00000425759ENST00000505113MED15chr22

20909435

+AHRRchr5

376725

+
intron-3CDSENST00000478831ENST00000316418MED15chr22

20909435

+AHRRchr5

376725

+
intron-3CDSENST00000478831ENST00000505113MED15chr22

20909435

+AHRRchr5

376725

+
intron-3CDSENST00000542773ENST00000316418MED15chr22

20909435

+AHRRchr5

376725

+
intron-3CDSENST00000542773ENST00000505113MED15chr22

20909435

+AHRRchr5

376725

+
intron-intronENST00000382974ENST00000506456MED15chr22

20909435

+AHRRchr5

376725

+
intron-intronENST00000382974ENST00000512529MED15chr22

20909435

+AHRRchr5

376725

+
intron-intronENST00000382974ENST00000515206MED15chr22

20909435

+AHRRchr5

376725

+
intron-intronENST00000425759ENST00000506456MED15chr22

20909435

+AHRRchr5

376725

+
intron-intronENST00000425759ENST00000512529MED15chr22

20909435

+AHRRchr5

376725

+
intron-intronENST00000425759ENST00000515206MED15chr22

20909435

+AHRRchr5

376725

+
intron-intronENST00000478831ENST00000506456MED15chr22

20909435

+AHRRchr5

376725

+
intron-intronENST00000478831ENST00000512529MED15chr22

20909435

+AHRRchr5

376725

+
intron-intronENST00000478831ENST00000515206MED15chr22

20909435

+AHRRchr5

376725

+
intron-intronENST00000542773ENST00000506456MED15chr22

20909435

+AHRRchr5

376725

+
intron-intronENST00000542773ENST00000512529MED15chr22

20909435

+AHRRchr5

376725

+
intron-intronENST00000542773ENST00000515206MED15chr22

20909435

+AHRRchr5

376725

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000292733MED15chr2220909435+ENST00000505113AHRRchr5376725+2401528772377766
ENST00000292733MED15chr2220909435+ENST00000316418AHRRchr5376725+5889528772431784
ENST00000263205MED15chr2220909435+ENST00000505113AHRRchr5376725+2393520692369766
ENST00000263205MED15chr2220909435+ENST00000316418AHRRchr5376725+5881520692423784
ENST00000406969MED15chr2220909435+ENST00000505113AHRRchr5376725+237450122350782
ENST00000406969MED15chr2220909435+ENST00000316418AHRRchr5376725+586250122404800
ENST00000541476MED15chr2220909435+ENST00000505113AHRRchr5376725+26497764032625740
ENST00000541476MED15chr2220909435+ENST00000316418AHRRchr5376725+61377764032679758

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000292733ENST00000505113MED15chr2220909435+AHRRchr5376725+0.054147460.9458525
ENST00000292733ENST00000316418MED15chr2220909435+AHRRchr5376725+0.0157280560.98427194
ENST00000263205ENST00000505113MED15chr2220909435+AHRRchr5376725+0.0539479070.9460521
ENST00000263205ENST00000316418MED15chr2220909435+AHRRchr5376725+0.0157312170.9842688
ENST00000406969ENST00000505113MED15chr2220909435+AHRRchr5376725+0.069441340.9305586
ENST00000406969ENST00000316418MED15chr2220909435+AHRRchr5376725+0.0278500430.97214997
ENST00000541476ENST00000505113MED15chr2220909435+AHRRchr5376725+0.0563300030.94367
ENST00000541476ENST00000316418MED15chr2220909435+AHRRchr5376725+0.0255907960.9744092

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Fusion Genomic Features for MED15-AHRR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MED15-AHRR


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:20909435/chr5:376725)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MED15

Q96RN5

AHRR

A9YTQ3

FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway. {ECO:0000269|PubMed:12167862, ECO:0000269|PubMed:16630888, ECO:0000269|PubMed:16799563}.FUNCTION: Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site. {ECO:0000269|PubMed:17890447, ECO:0000269|PubMed:18172554}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAHRRchr22:20909435chr5:376725ENST00000316418212112_18285720.0DomainPAS
TgeneAHRRchr22:20909435chr5:376725ENST00000505113211112_18285702.0DomainPAS
TgeneAHRRchr22:20909435chr5:376725ENST00000316418212551_70185720.0RegionNeeded for transcriptional repression
TgeneAHRRchr22:20909435chr5:376725ENST00000505113211551_70185702.0RegionNeeded for transcriptional repression

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMED15chr22:20909435chr5:376725ENST00000263205+518161_174150789.0Compositional biasNote=Poly-Gln
HgeneMED15chr22:20909435chr5:376725ENST00000263205+518178_193150789.0Compositional biasNote=Poly-Gln
HgeneMED15chr22:20909435chr5:376725ENST00000263205+518205_218150789.0Compositional biasNote=Poly-Gln
HgeneMED15chr22:20909435chr5:376725ENST00000263205+518226_239150789.0Compositional biasNote=Poly-Gln
HgeneMED15chr22:20909435chr5:376725ENST00000263205+518243_262150789.0Compositional biasNote=Poly-Gln
HgeneMED15chr22:20909435chr5:376725ENST00000263205+518266_515150789.0Compositional biasNote=Pro-rich
HgeneMED15chr22:20909435chr5:376725ENST00000263205+518360_367150789.0Compositional biasNote=Poly-Gln
HgeneMED15chr22:20909435chr5:376725ENST00000263205+518449_456150789.0Compositional biasNote=Poly-Pro
HgeneMED15chr22:20909435chr5:376725ENST00000263205+518602_611150789.0Compositional biasNote=Poly-Pro
HgeneMED15chr22:20909435chr5:376725ENST00000292733+517161_174150749.0Compositional biasNote=Poly-Gln
HgeneMED15chr22:20909435chr5:376725ENST00000292733+517178_193150749.0Compositional biasNote=Poly-Gln
HgeneMED15chr22:20909435chr5:376725ENST00000292733+517205_218150749.0Compositional biasNote=Poly-Gln
HgeneMED15chr22:20909435chr5:376725ENST00000292733+517226_239150749.0Compositional biasNote=Poly-Gln
HgeneMED15chr22:20909435chr5:376725ENST00000292733+517243_262150749.0Compositional biasNote=Poly-Gln
HgeneMED15chr22:20909435chr5:376725ENST00000292733+517266_515150749.0Compositional biasNote=Pro-rich
HgeneMED15chr22:20909435chr5:376725ENST00000292733+517360_367150749.0Compositional biasNote=Poly-Gln
HgeneMED15chr22:20909435chr5:376725ENST00000292733+517449_456150749.0Compositional biasNote=Poly-Pro
HgeneMED15chr22:20909435chr5:376725ENST00000292733+517602_611150749.0Compositional biasNote=Poly-Pro
HgeneMED15chr22:20909435chr5:376725ENST00000382974+116161_1740678.0Compositional biasNote=Poly-Gln
HgeneMED15chr22:20909435chr5:376725ENST00000382974+116178_1930678.0Compositional biasNote=Poly-Gln
HgeneMED15chr22:20909435chr5:376725ENST00000382974+116205_2180678.0Compositional biasNote=Poly-Gln
HgeneMED15chr22:20909435chr5:376725ENST00000382974+116226_2390678.0Compositional biasNote=Poly-Gln
HgeneMED15chr22:20909435chr5:376725ENST00000382974+116243_2620678.0Compositional biasNote=Poly-Gln
HgeneMED15chr22:20909435chr5:376725ENST00000382974+116266_5150678.0Compositional biasNote=Pro-rich
HgeneMED15chr22:20909435chr5:376725ENST00000382974+116360_3670678.0Compositional biasNote=Poly-Gln
HgeneMED15chr22:20909435chr5:376725ENST00000382974+116449_4560678.0Compositional biasNote=Poly-Pro
HgeneMED15chr22:20909435chr5:376725ENST00000382974+116602_6110678.0Compositional biasNote=Poly-Pro
HgeneMED15chr22:20909435chr5:376725ENST00000263205+518547_564150789.0MotifNuclear localization signal
HgeneMED15chr22:20909435chr5:376725ENST00000292733+517547_564150749.0MotifNuclear localization signal
HgeneMED15chr22:20909435chr5:376725ENST00000382974+116547_5640678.0MotifNuclear localization signal
TgeneAHRRchr22:20909435chr5:376725ENST0000031641821228_8185720.0DomainbHLH
TgeneAHRRchr22:20909435chr5:376725ENST0000050511321128_8185702.0DomainbHLH


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Fusion Gene Sequence for MED15-AHRR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>52605_52605_1_MED15-AHRR_MED15_chr22_20909435_ENST00000263205_AHRR_chr5_376725_ENST00000316418_length(transcript)=5881nt_BP=520nt
GGCTCTGTGACTGAGGCGGCGGCGGTGGCGGCCAAGCGGGATACGGGCGGCGGGAGCTGGGGAACAGGCATGGACGTTTCCGGGCAAGAG
ACCGACTGGCGGAGCACCGCCTTCCGGCAGAAGCTGGTCAGTCAAATCGAGGATGCCATGAGGAAAGCTGGTGTGGCACACAGTAAATCC
AGCAAGGATATGGAGAGCCATGTTTTCCTGAAGGCCAAGACCCGGGACGAATACCTTTCTCTCGTGGCCAGGCTCATTATCCATTTTCGA
GACATTCATAACAAGAAATCTCAAGCTTCCGTCAGTGATCCTATGAATGCACTCCAGAGCCTGACTGGCGGACCTGCTGCGGGAGCCGCT
GGAATTGGCATGCCTCCTCGGGGCCCGGGACAGTCTCTGGGCGGGATGGGTAGCCTTGGTGCCATGGGACAGCCAATGTCTCTCTCAGGG
CAGCCGCCTCCTGGGACCTCGGGGATGGCCCCTCACAGCATGGCTGTCGTGTCTACGGCAACTCCACAGATCGTGCAGGAGCAGAGCTCA
CGGCAGCCTGCGGCCGGCGCCCCCTCGCCCGGAGACAGCTGTCCTCTTGCAGGGTCTGCCGTGCTGGAGGGAAGGCTGCTGTTGGAGTCT
CTTAATGGCTTTGCTCTGGTCGTGAGTGCAGAAGGGACGATATTTTATGCATCAGCAACGATCGTGGACTATCTGGGCTTCCATCAGACG
GATGTAATGCACCAGAACATTTATGACTACATCCACGTGGACGACCGCCAGGACTTCTGCCGGCAGCTCCACTGGGCCATGGACCCTCCC
CAGGTGGTGTTTGGGCAGCCCCCGCCCTTGGAGACAGGAGATGATGCTATCCTGGGGAGGCTGCTCAGGGCCCAGGAGTGGGGCACAGGC
ACGCCCACCGAGTACTCGGCCTTCCTGACCCGCTGCTTCATCTGCCGTGTGCGCTGCCTGCTGGACAGCACCTCGGGCTTCCTGGCCCGG
GGGTCACAGGCTTGGCAGCTGCGGCTCTGCTGTCCCGAGCCACTCATGACGATGCAGTTTCAAGGAAAACTAAAATTCCTGTTTGGACAG
AAGAAGAAGGCGCCGTCAGGAGCCATGCTCCCGCCGCGGCTGTCGCTGTTCTGCATTGCGGCACCCGTTCTCCTCCCCTCCGCAGCGGAG
ATGAAAATGAGGAGCGCGCTCCTGAGGGCAAAACCCAGAGCAGACACCGCAGCCACCGCGGATGCAAAAGTAAAAGCCACCACCAGTCTG
TGCGAATCGGAACTGCATGGAAAACCCAATTACTCAGCAGGAAGGAGCAGCAGAGAGAGCGGCGTTTTGGTGCTCAGGGAACAGACTGAC
GCTGGCCGATGGGCACAGGTTCCCGCCAGGGCCCCATGCCTGTGCCTCCGGGGTGGCCCTGACCTTGTCCTTGACCCCAAGGGGGGCTCA
GGGGACAGGGAGGAGGAGCAGCACAGGATGCTGAGCAGGGCCTCTGGAGTGACAGGGCGGAGGGAGACTCCAGGACCCACAAAGCCCCTG
CCCTGGACAGCGGGAAAGCACAGTGAGGATGGTGCCAGGCCGAGGCTGCAGCCCAGCAAGAATGACCCGCCCTCCCTGCGCCCCATGCCC
CGCGGCTCCTGCCTGCCCTGCCCGTGTGTCCAGGGCACTTTCAGGAACTCGCCCATCTCTCACCCGCCGAGCCCGTCCCCCAGTGCCTAC
TCCAGCCGGACCAGCAGACCCATGCGGGATGTCGGTGAGGACCAGGTGCACCCTCCCCTCTGCCACTTTCCCCAGAGGAGCCTGCAGCAC
CAGCTCCCTCAGCCTGGAGCTCAGCGTTTTGCCACGAGGGGCTATCCCATGGAGGACATGAAGCTGCAAGGTGTACCGATGCCTCCGGGG
GACCTGTGTGGTCCGACGCTGCTGCTAGATGTGTCCATCAAGATGGAGAAGGACTCTGGGTGTGAGGGTGCTGCAGACGGCTGTGTGCCC
AGCCAGGTGTGGCTGGGGGCCAGTGACAGGAGCCACCCAGCCACCTTCCCTACCAGGATGCACCTGAAAACAGAGCCAGACTCTCGGCAA
CAGGTGTACATCTCGCACCTGGGGCACGGCGTGCGGGGGGCTCAGCCCCATGGGAGGGCCACTGCTGGGCGCAGCAGGGAGCTGACCCCT
TTCCACCCTGCACACTGTGCCTGCCTGGAGCCCACAGACGGCCTTCCCCAGTCGGAGCCTCCCCACCAGCTCTGTGCACGGGGCCGAGGT
GAACAGTCCTGCACCTGCAGAGCTGCTGAGGCCGCCCCTGTGGTCAAGCGGGAGCCCTTGGACTCACCCCAGTGGGCTACTCACAGCCAG
GGAATGGTGCCCGGGATGTTGCCCAAAAGTGCCTTGGCCACGCTGGTCCCGCCCCAAGCTTCGGGGTGCACATTCCTGCCATAGCGCAGT
GACCACCATCCAAGCTCAGATCTGTGTGTCTACGCTCAGATGCGTCGGTGGCTGGGCTGCCCTGCTCCTGGTCAGGCCGGAGCCCGTCCT
AAGACACACGCTTTGCAGAGCTGTGCATGCGCAGTCTGCTAGTGTGTGTGTGCAGCATACGCAGGAGCCTATCCTGAATTTTGTAAAATA
TCCCAACAGTTCTTAAATGAAAACTGGCCTTAAGTCTATTCAAGCATGACAGCATTTCTCTTTGAGGAATTAAAATCTTTAGGAAAGTGA
TCATGGCTGGACAGCTTCATGCCCCAGAGGCAGCGAGCACCCGTCCCATGGCTGCCAAGTCCACAGTCGGGGATGAAGCAGTCGGGTGAT
GCTCCCAAGTCCGCAGTCGGGGATGAAGCGGTCGGGTGATGCTCCCAAGTCCGCAGTCGGGGATGAAGCGGTCGGGTGACACACCTAGCT
CAGCCCTCCCAGGCCACCTGCAGCTCCCAGCCTGTGCTGTGCAGGCAGGGTCAGCCCATCGCCACAGTGCACTGTAGAGGCCAGCACACG
GCAAATTAGAAATACAACACGCGGAGAAAGGGGTCCGTGAGCCCACTCATAGAGGAATCTAGAACGTTCCAGGCAGCAGAGGCTGGCAGC
GTGGGTCCCACACTGCCCCACACCGTGCGGCAGGTGCTCCATGGCGCCATGACAGAGTCTGAGGCCAGACCTGGACTGGAATTGACAGCA
TAACCCCTGTTCCTTCTGGACATCTCCCGAGTTCTCAGTGGGTCTCTGCGGACGGTTCTTCCTAATCTGCCTCTTGGTACATCACGTAAT
ACAGAGTTCACAGACTCCGGGTTTGGAAGTACAGAGAAACACACAACGTAGAGAGAAGACACAGGAAACTGCGCTGCCTGTGGGGGTTTC
TCTCTGGCTGGCTGTACAGTTCACTCAAATGAGGGTTCCCATTGCCATCCTAGGAGAATAATTAGGGACAAGACAGACAAGTATTAATAG
CATTAAAACAGTTGTAAAGGCGATATTTTCTGAGAGTAGGAAATTTGGATACAAAAGCATAAGTCAGAAAGTGAAGGTCACCAATCCACC
AACCCGAGAACCTACAGCTGATGGTGCATTTCAGGCTTCTTCCACGGTCTGGCCTGGAACCCCACCCGGCTGGTGCAGGCATCAGATCAG
GGTGTAGAAGTCACCCCAAGCAAGAGGAAGCCAGGCAGTGAGGCCCTGGGGTGTGGCTGCAGCTGGGCCCACCTGTGCGGGGGTGGGAAG
GCCCCATCCTCAGGGAGAGGGCATCGGCGCCCTGACGTCAGCTCCACTGGGAGTGGCAGGAGCTGTGGGAGCCCATGGGTGAGGGACCCA
CCACCCCGCTGCACTGTGCATTGTGCCTCCCGTGTGGACGCCCTCTCTGTTGTTGGCCCGCGGGTGAGGGACCCACCACCCCTAGGGACC
CACCACCCCGCCGCACTGTGCATTCTGCCTCCTGTGTGGACGCCCTCTCTGTTGTCAGTGGCTTTGAGGTGTCAGTGCTTACTTAGATGC
TGGTTTAATGCTGGACCCATTTGTTAAACGCACCTTCACTTTGTCAAAACCCAGGTTTGGTTGGCAGGACTGGGTCTTCTGCCCAATGCC
AGGTGCCTGCGCCTCTCAGTGGCCTGGTTCTTGGACAGTTTGCCCCCATGTGGCAGGGATAGGGATAAGGATCTCCTCTCAGTACTGGAA
GAGAACAGCCAACCATCTGAGCCCAGAGTCACAGATCCATCGTGGCCCCCTATGACCCCCAAGCCCTACCGAGGGGGCACTCACTCTCTG
CTTAGCCAGGGGGCGTCTTTCAAAAGGTGACCTCCATGCTGTGCTGTCGTGGGTGTGAGACGTGCTCATGGCCTTCCACTGCCATCTCTC
CCTTATCTGATGCCTAAAGTCACGATGGGGACAGAGCTACCCAGGGGCCAGCCATGGGGTGACCAGCCACCTGAGGGTCAGTCACCTGTG
GAGAGCAGGCACCTGTGAAGACCAGGCACCTGAGGACTGGCGCCTACTTCCCACTTTGGCCCTACACTGGCACAGAGCCCCTCTTTATTC
ATTTCTCATGCTGAGCATGGCACACTTCTGGCCTCTGGGCATTTATGGATTTAAGACCAGGATGGTATTTCAGAAGCTTCCCACTTCCTT
CCTATTCTAACCGAGTGCCCAGCTCCTTTGCTGATCATGGAAAGACCCTTAATAATTAGGCCTGCAGGCCAGGCGCAGTGGCTCATGCCT
ATAATCCCAGCACTTTAGGAGGTCAAGGTAGGAGGATCGCTTAAGCCCAGGAGTTCAAGACCAGCCTGGGCAACACAGGAAGAATGTGTC
TCTACAAAAAATAATTAAAAATCAGATCTGCTGTATCCCTGAAAAAGTCTCAATCAACATGCATGTTCCACTCTTGGAGTTCCCTGTTCT
GAGGGCCAGCCACGTCCTGTGTCCTGGAGCTTAGCCCTCAGCAGCTCCCTTCAGCCTGGGCGCCGCCTGGGTCCCAAACGTGGCAGCTGC
TCTTCCAGTCTCGGGGCCGAGGAGGGCAGGGAGCTCAGTGACTGAGAGTCTTGTGTATCACATGTCTTGAGTGTCCTGGAGCCAACGGCT
GTCACTGGGAAAAACACCAGGCCCCAAAGATCGAATCAGAGACGTGGCTGCGTGTTTGCGATTGTAGCCAGGCCCTTCAGTGTCATCAAA
GGAGCACTGGGGCCTCCTTAAGCACAGACGGCAGCCCCTGCCCAGGAGGCTTCTTCACCACGTCCTGCCCTGCAGCCTCCCAGACCTTTA
GATGCGCCCCTGCCCAAGGCCCTCCTGGTGACAGGTGCCAGATTGAGTGGTGGGTTGCTGCCAGGCAGGCCACGCTGTGTTGACGCTGCA
CTCAGCACGTGGGTGTTGGCTCTGCCGGTTTTGTGGTGTGGGGACCCTACAGGAGGCTGCGGCCCTGAGAGCCTGGGATCAGCGAGGTGT
CCGACATCCCTTCCTCAACGGCAACAAAAACTCCCCAAGTCAGCACTTTGGTTATTTTATAGCCACAACCCTCTTGGAAAACAGTGGGGA
AGACTATGGAACATAGAAAGTGTGGATGTATCACTTCTCTCTAAAATGTCATTGTTAGCACTAATTACAGGTTCATGTTTTTCTGTGTAT
GTAGCTTTTCCCTATATAGCTGAAAAAGTATTAAAGTCAAATATAAGGTGGGAATGGGATGGAAGGGAGGAGATCAATACAACTTATATT
TTTGCAGTTTCTACTGGAAGAAAAAAGTTTTCAATACCTAGACCAACTTGTTGAATTTTTAAAACTTATGCACTATAAATGCAACTTTCT
CTACTGCTTTCTCAGTGCCTTTAGGAAGCTTTCAAATTTTTTTGTACTGTGGTTTGTATTAAATTTGCAATATTGATGTAAAATACATGA

>52605_52605_1_MED15-AHRR_MED15_chr22_20909435_ENST00000263205_AHRR_chr5_376725_ENST00000316418_length(amino acids)=784AA_BP=90
MDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTG
GPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQIVQEQSSRQPAAGAPSPGDSCPLAGSAVLE
GRLLLESLNGFALVVSAEGTIFYASATIVDYLGFHQTDVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQVVFGQPPPLETGDDAILGRLLR
AQEWGTGTPTEYSAFLTRCFICRVRCLLDSTSGFLARGSQAWQLRLCCPEPLMTMQFQGKLKFLFGQKKKAPSGAMLPPRLSLFCIAAPV
LLPSAAEMKMRSALLRAKPRADTAATADAKVKATTSLCESELHGKPNYSAGRSSRESGVLVLREQTDAGRWAQVPARAPCLCLRGGPDLV
LDPKGGSGDREEEQHRMLSRASGVTGRRETPGPTKPLPWTAGKHSEDGARPRLQPSKNDPPSLRPMPRGSCLPCPCVQGTFRNSPISHPP
SPSPSAYSSRTSRPMRDVGEDQVHPPLCHFPQRSLQHQLPQPGAQRFATRGYPMEDMKLQGVPMPPGDLCGPTLLLDVSIKMEKDSGCEG
AADGCVPSQVWLGASDRSHPATFPTRMHLKTEPDSRQQVYISHLGHGVRGAQPHGRATAGRSRELTPFHPAHCACLEPTDGLPQSEPPHQ

--------------------------------------------------------------
>52605_52605_2_MED15-AHRR_MED15_chr22_20909435_ENST00000263205_AHRR_chr5_376725_ENST00000505113_length(transcript)=2393nt_BP=520nt
GGCTCTGTGACTGAGGCGGCGGCGGTGGCGGCCAAGCGGGATACGGGCGGCGGGAGCTGGGGAACAGGCATGGACGTTTCCGGGCAAGAG
ACCGACTGGCGGAGCACCGCCTTCCGGCAGAAGCTGGTCAGTCAAATCGAGGATGCCATGAGGAAAGCTGGTGTGGCACACAGTAAATCC
AGCAAGGATATGGAGAGCCATGTTTTCCTGAAGGCCAAGACCCGGGACGAATACCTTTCTCTCGTGGCCAGGCTCATTATCCATTTTCGA
GACATTCATAACAAGAAATCTCAAGCTTCCGTCAGTGATCCTATGAATGCACTCCAGAGCCTGACTGGCGGACCTGCTGCGGGAGCCGCT
GGAATTGGCATGCCTCCTCGGGGCCCGGGACAGTCTCTGGGCGGGATGGGTAGCCTTGGTGCCATGGGACAGCCAATGTCTCTCTCAGGG
CAGCCGCCTCCTGGGACCTCGGGGATGGCCCCTCACAGCATGGCTGTCGTGTCTACGGCAACTCCACAGATCGTGCAGGAGCAGAGCTCA
CGGCAGCCTGCGGCCGGCGCCCCCTCGCCCGGAGACAGCTGTCCTCTTGCAGGGTCTGCCGTGCTGGAGGGAAGGCTGCTGTTGGAGTCT
CTTAATGGCTTTGCTCTGGTCGTGAGTGCAGAAGGGACGATATTTTATGCATCAGCAACGATCGTGGACTATCTGGGCTTCCATCAGACG
GATGTAATGCACCAGAACATTTATGACTACATCCACGTGGACGACCGCCAGGACTTCTGCCGGCAGCTCCACTGGGCCATGGACCCTCCC
CAGGTGGTGTTTGGGCAGCCCCCGCCCTTGGAGACAGGAGATGATGCTATCCTGGGGAGGCTGCTCAGGGCCCAGGAGTGGGGCACAGGC
ACGCCCACCGAGTACTCGGCCTTCCTGACCCGCTGCTTCATCTGCCGTGTGCGCTGCCTGCTGGACAGCACCTCGGGCTTCCTGACGATG
CAGTTTCAAGGAAAACTAAAATTCCTGTTTGGACAGAAGAAGAAGGCGCCGTCAGGAGCCATGCTCCCGCCGCGGCTGTCGCTGTTCTGC
ATTGCGGCACCCGTTCTCCTCCCCTCCGCAGCGGAGATGAAAATGAGGAGCGCGCTCCTGAGGGCAAAACCCAGAGCAGACACCGCAGCC
ACCGCGGATGCAAAAGTAAAAGCCACCACCAGTCTGTGCGAATCGGAACTGCATGGAAAACCCAATTACTCAGCAGGAAGGAGCAGCAGA
GAGAGCGGCGTTTTGGTGCTCAGGGAACAGACTGACGCTGGCCGATGGGCACAGGTTCCCGCCAGGGCCCCATGCCTGTGCCTCCGGGGT
GGCCCTGACCTTGTCCTTGACCCCAAGGGGGGCTCAGGGGACAGGGAGGAGGAGCAGCACAGGATGCTGAGCAGGGCCTCTGGAGTGACA
GGGCGGAGGGAGACTCCAGGACCCACAAAGCCCCTGCCCTGGACAGCGGGAAAGCACAGTGAGGATGGTGCCAGGCCGAGGCTGCAGCCC
AGCAAGAATGACCCGCCCTCCCTGCGCCCCATGCCCCGCGGCTCCTGCCTGCCCTGCCCGTGTGTCCAGGGCACTTTCAGGAACTCGCCC
ATCTCTCACCCGCCGAGCCCGTCCCCCAGTGCCTACTCCAGCCGGACCAGCAGACCCATGCGGGATGTCGGTGAGGACCAGGTGCACCCT
CCCCTCTGCCACTTTCCCCAGAGGAGCCTGCAGCACCAGCTCCCTCAGCCTGGAGCTCAGCGTTTTGCCACGAGGGGCTATCCCATGGAG
GACATGAAGCTGCAAGGTGTACCGATGCCTCCGGGGGACCTGTGTGGTCCGACGCTGCTGCTAGATGTGTCCATCAAGATGGAGAAGGAC
TCTGGGTGTGAGGGTGCTGCAGACGGCTGTGTGCCCAGCCAGGTGTGGCTGGGGGCCAGTGACAGGAGCCACCCAGCCACCTTCCCTACC
AGGATGCACCTGAAAACAGAGCCAGACTCTCGGCAACAGGTGTACATCTCGCACCTGGGGCACGGCGTGCGGGGGGCTCAGCCCCATGGG
AGGGCCACTGCTGGGCGCAGCAGGGAGCTGACCCCTTTCCACCCTGCACACTGTGCCTGCCTGGAGCCCACAGACGGCCTTCCCCAGTCG
GAGCCTCCCCACCAGCTCTGTGCACGGGGCCGAGGTGAACAGTCCTGCACCTGCAGAGCTGCTGAGGCCGCCCCTGTGGTCAAGCGGGAG
CCCTTGGACTCACCCCAGTGGGCTACTCACAGCCAGGGAATGGTGCCCGGGATGTTGCCCAAAAGTGCCTTGGCCACGCTGGTCCCGCCC

>52605_52605_2_MED15-AHRR_MED15_chr22_20909435_ENST00000263205_AHRR_chr5_376725_ENST00000505113_length(amino acids)=766AA_BP=90
MDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTG
GPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQIVQEQSSRQPAAGAPSPGDSCPLAGSAVLE
GRLLLESLNGFALVVSAEGTIFYASATIVDYLGFHQTDVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQVVFGQPPPLETGDDAILGRLLR
AQEWGTGTPTEYSAFLTRCFICRVRCLLDSTSGFLTMQFQGKLKFLFGQKKKAPSGAMLPPRLSLFCIAAPVLLPSAAEMKMRSALLRAK
PRADTAATADAKVKATTSLCESELHGKPNYSAGRSSRESGVLVLREQTDAGRWAQVPARAPCLCLRGGPDLVLDPKGGSGDREEEQHRML
SRASGVTGRRETPGPTKPLPWTAGKHSEDGARPRLQPSKNDPPSLRPMPRGSCLPCPCVQGTFRNSPISHPPSPSPSAYSSRTSRPMRDV
GEDQVHPPLCHFPQRSLQHQLPQPGAQRFATRGYPMEDMKLQGVPMPPGDLCGPTLLLDVSIKMEKDSGCEGAADGCVPSQVWLGASDRS
HPATFPTRMHLKTEPDSRQQVYISHLGHGVRGAQPHGRATAGRSRELTPFHPAHCACLEPTDGLPQSEPPHQLCARGRGEQSCTCRAAEA

--------------------------------------------------------------
>52605_52605_3_MED15-AHRR_MED15_chr22_20909435_ENST00000292733_AHRR_chr5_376725_ENST00000316418_length(transcript)=5889nt_BP=528nt
TTGGGCCTGGCTCTGTGACTGAGGCGGCGGCGGTGGCGGCCAAGCGGGATACGGGCGGCGGGAGCTGGGGAACAGGCATGGACGTTTCCG
GGCAAGAGACCGACTGGCGGAGCACCGCCTTCCGGCAGAAGCTGGTCAGTCAAATCGAGGATGCCATGAGGAAAGCTGGTGTGGCACACA
GTAAATCCAGCAAGGATATGGAGAGCCATGTTTTCCTGAAGGCCAAGACCCGGGACGAATACCTTTCTCTCGTGGCCAGGCTCATTATCC
ATTTTCGAGACATTCATAACAAGAAATCTCAAGCTTCCGTCAGTGATCCTATGAATGCACTCCAGAGCCTGACTGGCGGACCTGCTGCGG
GAGCCGCTGGAATTGGCATGCCTCCTCGGGGCCCGGGACAGTCTCTGGGCGGGATGGGTAGCCTTGGTGCCATGGGACAGCCAATGTCTC
TCTCAGGGCAGCCGCCTCCTGGGACCTCGGGGATGGCCCCTCACAGCATGGCTGTCGTGTCTACGGCAACTCCACAGATCGTGCAGGAGC
AGAGCTCACGGCAGCCTGCGGCCGGCGCCCCCTCGCCCGGAGACAGCTGTCCTCTTGCAGGGTCTGCCGTGCTGGAGGGAAGGCTGCTGT
TGGAGTCTCTTAATGGCTTTGCTCTGGTCGTGAGTGCAGAAGGGACGATATTTTATGCATCAGCAACGATCGTGGACTATCTGGGCTTCC
ATCAGACGGATGTAATGCACCAGAACATTTATGACTACATCCACGTGGACGACCGCCAGGACTTCTGCCGGCAGCTCCACTGGGCCATGG
ACCCTCCCCAGGTGGTGTTTGGGCAGCCCCCGCCCTTGGAGACAGGAGATGATGCTATCCTGGGGAGGCTGCTCAGGGCCCAGGAGTGGG
GCACAGGCACGCCCACCGAGTACTCGGCCTTCCTGACCCGCTGCTTCATCTGCCGTGTGCGCTGCCTGCTGGACAGCACCTCGGGCTTCC
TGGCCCGGGGGTCACAGGCTTGGCAGCTGCGGCTCTGCTGTCCCGAGCCACTCATGACGATGCAGTTTCAAGGAAAACTAAAATTCCTGT
TTGGACAGAAGAAGAAGGCGCCGTCAGGAGCCATGCTCCCGCCGCGGCTGTCGCTGTTCTGCATTGCGGCACCCGTTCTCCTCCCCTCCG
CAGCGGAGATGAAAATGAGGAGCGCGCTCCTGAGGGCAAAACCCAGAGCAGACACCGCAGCCACCGCGGATGCAAAAGTAAAAGCCACCA
CCAGTCTGTGCGAATCGGAACTGCATGGAAAACCCAATTACTCAGCAGGAAGGAGCAGCAGAGAGAGCGGCGTTTTGGTGCTCAGGGAAC
AGACTGACGCTGGCCGATGGGCACAGGTTCCCGCCAGGGCCCCATGCCTGTGCCTCCGGGGTGGCCCTGACCTTGTCCTTGACCCCAAGG
GGGGCTCAGGGGACAGGGAGGAGGAGCAGCACAGGATGCTGAGCAGGGCCTCTGGAGTGACAGGGCGGAGGGAGACTCCAGGACCCACAA
AGCCCCTGCCCTGGACAGCGGGAAAGCACAGTGAGGATGGTGCCAGGCCGAGGCTGCAGCCCAGCAAGAATGACCCGCCCTCCCTGCGCC
CCATGCCCCGCGGCTCCTGCCTGCCCTGCCCGTGTGTCCAGGGCACTTTCAGGAACTCGCCCATCTCTCACCCGCCGAGCCCGTCCCCCA
GTGCCTACTCCAGCCGGACCAGCAGACCCATGCGGGATGTCGGTGAGGACCAGGTGCACCCTCCCCTCTGCCACTTTCCCCAGAGGAGCC
TGCAGCACCAGCTCCCTCAGCCTGGAGCTCAGCGTTTTGCCACGAGGGGCTATCCCATGGAGGACATGAAGCTGCAAGGTGTACCGATGC
CTCCGGGGGACCTGTGTGGTCCGACGCTGCTGCTAGATGTGTCCATCAAGATGGAGAAGGACTCTGGGTGTGAGGGTGCTGCAGACGGCT
GTGTGCCCAGCCAGGTGTGGCTGGGGGCCAGTGACAGGAGCCACCCAGCCACCTTCCCTACCAGGATGCACCTGAAAACAGAGCCAGACT
CTCGGCAACAGGTGTACATCTCGCACCTGGGGCACGGCGTGCGGGGGGCTCAGCCCCATGGGAGGGCCACTGCTGGGCGCAGCAGGGAGC
TGACCCCTTTCCACCCTGCACACTGTGCCTGCCTGGAGCCCACAGACGGCCTTCCCCAGTCGGAGCCTCCCCACCAGCTCTGTGCACGGG
GCCGAGGTGAACAGTCCTGCACCTGCAGAGCTGCTGAGGCCGCCCCTGTGGTCAAGCGGGAGCCCTTGGACTCACCCCAGTGGGCTACTC
ACAGCCAGGGAATGGTGCCCGGGATGTTGCCCAAAAGTGCCTTGGCCACGCTGGTCCCGCCCCAAGCTTCGGGGTGCACATTCCTGCCAT
AGCGCAGTGACCACCATCCAAGCTCAGATCTGTGTGTCTACGCTCAGATGCGTCGGTGGCTGGGCTGCCCTGCTCCTGGTCAGGCCGGAG
CCCGTCCTAAGACACACGCTTTGCAGAGCTGTGCATGCGCAGTCTGCTAGTGTGTGTGTGCAGCATACGCAGGAGCCTATCCTGAATTTT
GTAAAATATCCCAACAGTTCTTAAATGAAAACTGGCCTTAAGTCTATTCAAGCATGACAGCATTTCTCTTTGAGGAATTAAAATCTTTAG
GAAAGTGATCATGGCTGGACAGCTTCATGCCCCAGAGGCAGCGAGCACCCGTCCCATGGCTGCCAAGTCCACAGTCGGGGATGAAGCAGT
CGGGTGATGCTCCCAAGTCCGCAGTCGGGGATGAAGCGGTCGGGTGATGCTCCCAAGTCCGCAGTCGGGGATGAAGCGGTCGGGTGACAC
ACCTAGCTCAGCCCTCCCAGGCCACCTGCAGCTCCCAGCCTGTGCTGTGCAGGCAGGGTCAGCCCATCGCCACAGTGCACTGTAGAGGCC
AGCACACGGCAAATTAGAAATACAACACGCGGAGAAAGGGGTCCGTGAGCCCACTCATAGAGGAATCTAGAACGTTCCAGGCAGCAGAGG
CTGGCAGCGTGGGTCCCACACTGCCCCACACCGTGCGGCAGGTGCTCCATGGCGCCATGACAGAGTCTGAGGCCAGACCTGGACTGGAAT
TGACAGCATAACCCCTGTTCCTTCTGGACATCTCCCGAGTTCTCAGTGGGTCTCTGCGGACGGTTCTTCCTAATCTGCCTCTTGGTACAT
CACGTAATACAGAGTTCACAGACTCCGGGTTTGGAAGTACAGAGAAACACACAACGTAGAGAGAAGACACAGGAAACTGCGCTGCCTGTG
GGGGTTTCTCTCTGGCTGGCTGTACAGTTCACTCAAATGAGGGTTCCCATTGCCATCCTAGGAGAATAATTAGGGACAAGACAGACAAGT
ATTAATAGCATTAAAACAGTTGTAAAGGCGATATTTTCTGAGAGTAGGAAATTTGGATACAAAAGCATAAGTCAGAAAGTGAAGGTCACC
AATCCACCAACCCGAGAACCTACAGCTGATGGTGCATTTCAGGCTTCTTCCACGGTCTGGCCTGGAACCCCACCCGGCTGGTGCAGGCAT
CAGATCAGGGTGTAGAAGTCACCCCAAGCAAGAGGAAGCCAGGCAGTGAGGCCCTGGGGTGTGGCTGCAGCTGGGCCCACCTGTGCGGGG
GTGGGAAGGCCCCATCCTCAGGGAGAGGGCATCGGCGCCCTGACGTCAGCTCCACTGGGAGTGGCAGGAGCTGTGGGAGCCCATGGGTGA
GGGACCCACCACCCCGCTGCACTGTGCATTGTGCCTCCCGTGTGGACGCCCTCTCTGTTGTTGGCCCGCGGGTGAGGGACCCACCACCCC
TAGGGACCCACCACCCCGCCGCACTGTGCATTCTGCCTCCTGTGTGGACGCCCTCTCTGTTGTCAGTGGCTTTGAGGTGTCAGTGCTTAC
TTAGATGCTGGTTTAATGCTGGACCCATTTGTTAAACGCACCTTCACTTTGTCAAAACCCAGGTTTGGTTGGCAGGACTGGGTCTTCTGC
CCAATGCCAGGTGCCTGCGCCTCTCAGTGGCCTGGTTCTTGGACAGTTTGCCCCCATGTGGCAGGGATAGGGATAAGGATCTCCTCTCAG
TACTGGAAGAGAACAGCCAACCATCTGAGCCCAGAGTCACAGATCCATCGTGGCCCCCTATGACCCCCAAGCCCTACCGAGGGGGCACTC
ACTCTCTGCTTAGCCAGGGGGCGTCTTTCAAAAGGTGACCTCCATGCTGTGCTGTCGTGGGTGTGAGACGTGCTCATGGCCTTCCACTGC
CATCTCTCCCTTATCTGATGCCTAAAGTCACGATGGGGACAGAGCTACCCAGGGGCCAGCCATGGGGTGACCAGCCACCTGAGGGTCAGT
CACCTGTGGAGAGCAGGCACCTGTGAAGACCAGGCACCTGAGGACTGGCGCCTACTTCCCACTTTGGCCCTACACTGGCACAGAGCCCCT
CTTTATTCATTTCTCATGCTGAGCATGGCACACTTCTGGCCTCTGGGCATTTATGGATTTAAGACCAGGATGGTATTTCAGAAGCTTCCC
ACTTCCTTCCTATTCTAACCGAGTGCCCAGCTCCTTTGCTGATCATGGAAAGACCCTTAATAATTAGGCCTGCAGGCCAGGCGCAGTGGC
TCATGCCTATAATCCCAGCACTTTAGGAGGTCAAGGTAGGAGGATCGCTTAAGCCCAGGAGTTCAAGACCAGCCTGGGCAACACAGGAAG
AATGTGTCTCTACAAAAAATAATTAAAAATCAGATCTGCTGTATCCCTGAAAAAGTCTCAATCAACATGCATGTTCCACTCTTGGAGTTC
CCTGTTCTGAGGGCCAGCCACGTCCTGTGTCCTGGAGCTTAGCCCTCAGCAGCTCCCTTCAGCCTGGGCGCCGCCTGGGTCCCAAACGTG
GCAGCTGCTCTTCCAGTCTCGGGGCCGAGGAGGGCAGGGAGCTCAGTGACTGAGAGTCTTGTGTATCACATGTCTTGAGTGTCCTGGAGC
CAACGGCTGTCACTGGGAAAAACACCAGGCCCCAAAGATCGAATCAGAGACGTGGCTGCGTGTTTGCGATTGTAGCCAGGCCCTTCAGTG
TCATCAAAGGAGCACTGGGGCCTCCTTAAGCACAGACGGCAGCCCCTGCCCAGGAGGCTTCTTCACCACGTCCTGCCCTGCAGCCTCCCA
GACCTTTAGATGCGCCCCTGCCCAAGGCCCTCCTGGTGACAGGTGCCAGATTGAGTGGTGGGTTGCTGCCAGGCAGGCCACGCTGTGTTG
ACGCTGCACTCAGCACGTGGGTGTTGGCTCTGCCGGTTTTGTGGTGTGGGGACCCTACAGGAGGCTGCGGCCCTGAGAGCCTGGGATCAG
CGAGGTGTCCGACATCCCTTCCTCAACGGCAACAAAAACTCCCCAAGTCAGCACTTTGGTTATTTTATAGCCACAACCCTCTTGGAAAAC
AGTGGGGAAGACTATGGAACATAGAAAGTGTGGATGTATCACTTCTCTCTAAAATGTCATTGTTAGCACTAATTACAGGTTCATGTTTTT
CTGTGTATGTAGCTTTTCCCTATATAGCTGAAAAAGTATTAAAGTCAAATATAAGGTGGGAATGGGATGGAAGGGAGGAGATCAATACAA
CTTATATTTTTGCAGTTTCTACTGGAAGAAAAAAGTTTTCAATACCTAGACCAACTTGTTGAATTTTTAAAACTTATGCACTATAAATGC
AACTTTCTCTACTGCTTTCTCAGTGCCTTTAGGAAGCTTTCAAATTTTTTTGTACTGTGGTTTGTATTAAATTTGCAATATTGATGTAAA

>52605_52605_3_MED15-AHRR_MED15_chr22_20909435_ENST00000292733_AHRR_chr5_376725_ENST00000316418_length(amino acids)=784AA_BP=90
MDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTG
GPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQIVQEQSSRQPAAGAPSPGDSCPLAGSAVLE
GRLLLESLNGFALVVSAEGTIFYASATIVDYLGFHQTDVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQVVFGQPPPLETGDDAILGRLLR
AQEWGTGTPTEYSAFLTRCFICRVRCLLDSTSGFLARGSQAWQLRLCCPEPLMTMQFQGKLKFLFGQKKKAPSGAMLPPRLSLFCIAAPV
LLPSAAEMKMRSALLRAKPRADTAATADAKVKATTSLCESELHGKPNYSAGRSSRESGVLVLREQTDAGRWAQVPARAPCLCLRGGPDLV
LDPKGGSGDREEEQHRMLSRASGVTGRRETPGPTKPLPWTAGKHSEDGARPRLQPSKNDPPSLRPMPRGSCLPCPCVQGTFRNSPISHPP
SPSPSAYSSRTSRPMRDVGEDQVHPPLCHFPQRSLQHQLPQPGAQRFATRGYPMEDMKLQGVPMPPGDLCGPTLLLDVSIKMEKDSGCEG
AADGCVPSQVWLGASDRSHPATFPTRMHLKTEPDSRQQVYISHLGHGVRGAQPHGRATAGRSRELTPFHPAHCACLEPTDGLPQSEPPHQ

--------------------------------------------------------------
>52605_52605_4_MED15-AHRR_MED15_chr22_20909435_ENST00000292733_AHRR_chr5_376725_ENST00000505113_length(transcript)=2401nt_BP=528nt
TTGGGCCTGGCTCTGTGACTGAGGCGGCGGCGGTGGCGGCCAAGCGGGATACGGGCGGCGGGAGCTGGGGAACAGGCATGGACGTTTCCG
GGCAAGAGACCGACTGGCGGAGCACCGCCTTCCGGCAGAAGCTGGTCAGTCAAATCGAGGATGCCATGAGGAAAGCTGGTGTGGCACACA
GTAAATCCAGCAAGGATATGGAGAGCCATGTTTTCCTGAAGGCCAAGACCCGGGACGAATACCTTTCTCTCGTGGCCAGGCTCATTATCC
ATTTTCGAGACATTCATAACAAGAAATCTCAAGCTTCCGTCAGTGATCCTATGAATGCACTCCAGAGCCTGACTGGCGGACCTGCTGCGG
GAGCCGCTGGAATTGGCATGCCTCCTCGGGGCCCGGGACAGTCTCTGGGCGGGATGGGTAGCCTTGGTGCCATGGGACAGCCAATGTCTC
TCTCAGGGCAGCCGCCTCCTGGGACCTCGGGGATGGCCCCTCACAGCATGGCTGTCGTGTCTACGGCAACTCCACAGATCGTGCAGGAGC
AGAGCTCACGGCAGCCTGCGGCCGGCGCCCCCTCGCCCGGAGACAGCTGTCCTCTTGCAGGGTCTGCCGTGCTGGAGGGAAGGCTGCTGT
TGGAGTCTCTTAATGGCTTTGCTCTGGTCGTGAGTGCAGAAGGGACGATATTTTATGCATCAGCAACGATCGTGGACTATCTGGGCTTCC
ATCAGACGGATGTAATGCACCAGAACATTTATGACTACATCCACGTGGACGACCGCCAGGACTTCTGCCGGCAGCTCCACTGGGCCATGG
ACCCTCCCCAGGTGGTGTTTGGGCAGCCCCCGCCCTTGGAGACAGGAGATGATGCTATCCTGGGGAGGCTGCTCAGGGCCCAGGAGTGGG
GCACAGGCACGCCCACCGAGTACTCGGCCTTCCTGACCCGCTGCTTCATCTGCCGTGTGCGCTGCCTGCTGGACAGCACCTCGGGCTTCC
TGACGATGCAGTTTCAAGGAAAACTAAAATTCCTGTTTGGACAGAAGAAGAAGGCGCCGTCAGGAGCCATGCTCCCGCCGCGGCTGTCGC
TGTTCTGCATTGCGGCACCCGTTCTCCTCCCCTCCGCAGCGGAGATGAAAATGAGGAGCGCGCTCCTGAGGGCAAAACCCAGAGCAGACA
CCGCAGCCACCGCGGATGCAAAAGTAAAAGCCACCACCAGTCTGTGCGAATCGGAACTGCATGGAAAACCCAATTACTCAGCAGGAAGGA
GCAGCAGAGAGAGCGGCGTTTTGGTGCTCAGGGAACAGACTGACGCTGGCCGATGGGCACAGGTTCCCGCCAGGGCCCCATGCCTGTGCC
TCCGGGGTGGCCCTGACCTTGTCCTTGACCCCAAGGGGGGCTCAGGGGACAGGGAGGAGGAGCAGCACAGGATGCTGAGCAGGGCCTCTG
GAGTGACAGGGCGGAGGGAGACTCCAGGACCCACAAAGCCCCTGCCCTGGACAGCGGGAAAGCACAGTGAGGATGGTGCCAGGCCGAGGC
TGCAGCCCAGCAAGAATGACCCGCCCTCCCTGCGCCCCATGCCCCGCGGCTCCTGCCTGCCCTGCCCGTGTGTCCAGGGCACTTTCAGGA
ACTCGCCCATCTCTCACCCGCCGAGCCCGTCCCCCAGTGCCTACTCCAGCCGGACCAGCAGACCCATGCGGGATGTCGGTGAGGACCAGG
TGCACCCTCCCCTCTGCCACTTTCCCCAGAGGAGCCTGCAGCACCAGCTCCCTCAGCCTGGAGCTCAGCGTTTTGCCACGAGGGGCTATC
CCATGGAGGACATGAAGCTGCAAGGTGTACCGATGCCTCCGGGGGACCTGTGTGGTCCGACGCTGCTGCTAGATGTGTCCATCAAGATGG
AGAAGGACTCTGGGTGTGAGGGTGCTGCAGACGGCTGTGTGCCCAGCCAGGTGTGGCTGGGGGCCAGTGACAGGAGCCACCCAGCCACCT
TCCCTACCAGGATGCACCTGAAAACAGAGCCAGACTCTCGGCAACAGGTGTACATCTCGCACCTGGGGCACGGCGTGCGGGGGGCTCAGC
CCCATGGGAGGGCCACTGCTGGGCGCAGCAGGGAGCTGACCCCTTTCCACCCTGCACACTGTGCCTGCCTGGAGCCCACAGACGGCCTTC
CCCAGTCGGAGCCTCCCCACCAGCTCTGTGCACGGGGCCGAGGTGAACAGTCCTGCACCTGCAGAGCTGCTGAGGCCGCCCCTGTGGTCA
AGCGGGAGCCCTTGGACTCACCCCAGTGGGCTACTCACAGCCAGGGAATGGTGCCCGGGATGTTGCCCAAAAGTGCCTTGGCCACGCTGG

>52605_52605_4_MED15-AHRR_MED15_chr22_20909435_ENST00000292733_AHRR_chr5_376725_ENST00000505113_length(amino acids)=766AA_BP=90
MDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTG
GPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQIVQEQSSRQPAAGAPSPGDSCPLAGSAVLE
GRLLLESLNGFALVVSAEGTIFYASATIVDYLGFHQTDVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQVVFGQPPPLETGDDAILGRLLR
AQEWGTGTPTEYSAFLTRCFICRVRCLLDSTSGFLTMQFQGKLKFLFGQKKKAPSGAMLPPRLSLFCIAAPVLLPSAAEMKMRSALLRAK
PRADTAATADAKVKATTSLCESELHGKPNYSAGRSSRESGVLVLREQTDAGRWAQVPARAPCLCLRGGPDLVLDPKGGSGDREEEQHRML
SRASGVTGRRETPGPTKPLPWTAGKHSEDGARPRLQPSKNDPPSLRPMPRGSCLPCPCVQGTFRNSPISHPPSPSPSAYSSRTSRPMRDV
GEDQVHPPLCHFPQRSLQHQLPQPGAQRFATRGYPMEDMKLQGVPMPPGDLCGPTLLLDVSIKMEKDSGCEGAADGCVPSQVWLGASDRS
HPATFPTRMHLKTEPDSRQQVYISHLGHGVRGAQPHGRATAGRSRELTPFHPAHCACLEPTDGLPQSEPPHQLCARGRGEQSCTCRAAEA

--------------------------------------------------------------
>52605_52605_5_MED15-AHRR_MED15_chr22_20909435_ENST00000406969_AHRR_chr5_376725_ENST00000316418_length(transcript)=5862nt_BP=501nt
GACTGAGGCGGCGGCGGTGGCGGCCAAGCGGGATACGGGCGGCGGGAGCTGGGGAACAGGCATGGACGTTTCCGGGCAAGAGACCGACTG
GCGGAGCACCGCCTTCCGGCAGAAGCTGCGAGGATGCCATGAGGAAAGCTGGTGTGGCACACAGTAAATCCAGCAAGGATATGGAGAGCC
ATGTTTTCCTGAAGGCCAAGACCCGGGACGAATACCTTTCTCTCGTGGCCAGGCTCATTATCCATTTTCGAGACATTCATAACAAGAAAT
CTCAAGCTTCCGTCAGTGATCCTATGAATGCACTCCAGAGCCTGACTGGCGGACCTGCTGCGGGAGCCGCTGGAATTGGCATGCCTCCTC
GGGGCCCGGGACAGTCTCTGGGCGGGATGGGTAGCCTTGGTGCCATGGGACAGCCAATGTCTCTCTCAGGGCAGCCGCCTCCTGGGACCT
CGGGGATGGCCCCTCACAGCATGGCTGTCGTGTCTACGGCAACTCCACAGATCGTGCAGGAGCAGAGCTCACGGCAGCCTGCGGCCGGCG
CCCCCTCGCCCGGAGACAGCTGTCCTCTTGCAGGGTCTGCCGTGCTGGAGGGAAGGCTGCTGTTGGAGTCTCTTAATGGCTTTGCTCTGG
TCGTGAGTGCAGAAGGGACGATATTTTATGCATCAGCAACGATCGTGGACTATCTGGGCTTCCATCAGACGGATGTAATGCACCAGAACA
TTTATGACTACATCCACGTGGACGACCGCCAGGACTTCTGCCGGCAGCTCCACTGGGCCATGGACCCTCCCCAGGTGGTGTTTGGGCAGC
CCCCGCCCTTGGAGACAGGAGATGATGCTATCCTGGGGAGGCTGCTCAGGGCCCAGGAGTGGGGCACAGGCACGCCCACCGAGTACTCGG
CCTTCCTGACCCGCTGCTTCATCTGCCGTGTGCGCTGCCTGCTGGACAGCACCTCGGGCTTCCTGGCCCGGGGGTCACAGGCTTGGCAGC
TGCGGCTCTGCTGTCCCGAGCCACTCATGACGATGCAGTTTCAAGGAAAACTAAAATTCCTGTTTGGACAGAAGAAGAAGGCGCCGTCAG
GAGCCATGCTCCCGCCGCGGCTGTCGCTGTTCTGCATTGCGGCACCCGTTCTCCTCCCCTCCGCAGCGGAGATGAAAATGAGGAGCGCGC
TCCTGAGGGCAAAACCCAGAGCAGACACCGCAGCCACCGCGGATGCAAAAGTAAAAGCCACCACCAGTCTGTGCGAATCGGAACTGCATG
GAAAACCCAATTACTCAGCAGGAAGGAGCAGCAGAGAGAGCGGCGTTTTGGTGCTCAGGGAACAGACTGACGCTGGCCGATGGGCACAGG
TTCCCGCCAGGGCCCCATGCCTGTGCCTCCGGGGTGGCCCTGACCTTGTCCTTGACCCCAAGGGGGGCTCAGGGGACAGGGAGGAGGAGC
AGCACAGGATGCTGAGCAGGGCCTCTGGAGTGACAGGGCGGAGGGAGACTCCAGGACCCACAAAGCCCCTGCCCTGGACAGCGGGAAAGC
ACAGTGAGGATGGTGCCAGGCCGAGGCTGCAGCCCAGCAAGAATGACCCGCCCTCCCTGCGCCCCATGCCCCGCGGCTCCTGCCTGCCCT
GCCCGTGTGTCCAGGGCACTTTCAGGAACTCGCCCATCTCTCACCCGCCGAGCCCGTCCCCCAGTGCCTACTCCAGCCGGACCAGCAGAC
CCATGCGGGATGTCGGTGAGGACCAGGTGCACCCTCCCCTCTGCCACTTTCCCCAGAGGAGCCTGCAGCACCAGCTCCCTCAGCCTGGAG
CTCAGCGTTTTGCCACGAGGGGCTATCCCATGGAGGACATGAAGCTGCAAGGTGTACCGATGCCTCCGGGGGACCTGTGTGGTCCGACGC
TGCTGCTAGATGTGTCCATCAAGATGGAGAAGGACTCTGGGTGTGAGGGTGCTGCAGACGGCTGTGTGCCCAGCCAGGTGTGGCTGGGGG
CCAGTGACAGGAGCCACCCAGCCACCTTCCCTACCAGGATGCACCTGAAAACAGAGCCAGACTCTCGGCAACAGGTGTACATCTCGCACC
TGGGGCACGGCGTGCGGGGGGCTCAGCCCCATGGGAGGGCCACTGCTGGGCGCAGCAGGGAGCTGACCCCTTTCCACCCTGCACACTGTG
CCTGCCTGGAGCCCACAGACGGCCTTCCCCAGTCGGAGCCTCCCCACCAGCTCTGTGCACGGGGCCGAGGTGAACAGTCCTGCACCTGCA
GAGCTGCTGAGGCCGCCCCTGTGGTCAAGCGGGAGCCCTTGGACTCACCCCAGTGGGCTACTCACAGCCAGGGAATGGTGCCCGGGATGT
TGCCCAAAAGTGCCTTGGCCACGCTGGTCCCGCCCCAAGCTTCGGGGTGCACATTCCTGCCATAGCGCAGTGACCACCATCCAAGCTCAG
ATCTGTGTGTCTACGCTCAGATGCGTCGGTGGCTGGGCTGCCCTGCTCCTGGTCAGGCCGGAGCCCGTCCTAAGACACACGCTTTGCAGA
GCTGTGCATGCGCAGTCTGCTAGTGTGTGTGTGCAGCATACGCAGGAGCCTATCCTGAATTTTGTAAAATATCCCAACAGTTCTTAAATG
AAAACTGGCCTTAAGTCTATTCAAGCATGACAGCATTTCTCTTTGAGGAATTAAAATCTTTAGGAAAGTGATCATGGCTGGACAGCTTCA
TGCCCCAGAGGCAGCGAGCACCCGTCCCATGGCTGCCAAGTCCACAGTCGGGGATGAAGCAGTCGGGTGATGCTCCCAAGTCCGCAGTCG
GGGATGAAGCGGTCGGGTGATGCTCCCAAGTCCGCAGTCGGGGATGAAGCGGTCGGGTGACACACCTAGCTCAGCCCTCCCAGGCCACCT
GCAGCTCCCAGCCTGTGCTGTGCAGGCAGGGTCAGCCCATCGCCACAGTGCACTGTAGAGGCCAGCACACGGCAAATTAGAAATACAACA
CGCGGAGAAAGGGGTCCGTGAGCCCACTCATAGAGGAATCTAGAACGTTCCAGGCAGCAGAGGCTGGCAGCGTGGGTCCCACACTGCCCC
ACACCGTGCGGCAGGTGCTCCATGGCGCCATGACAGAGTCTGAGGCCAGACCTGGACTGGAATTGACAGCATAACCCCTGTTCCTTCTGG
ACATCTCCCGAGTTCTCAGTGGGTCTCTGCGGACGGTTCTTCCTAATCTGCCTCTTGGTACATCACGTAATACAGAGTTCACAGACTCCG
GGTTTGGAAGTACAGAGAAACACACAACGTAGAGAGAAGACACAGGAAACTGCGCTGCCTGTGGGGGTTTCTCTCTGGCTGGCTGTACAG
TTCACTCAAATGAGGGTTCCCATTGCCATCCTAGGAGAATAATTAGGGACAAGACAGACAAGTATTAATAGCATTAAAACAGTTGTAAAG
GCGATATTTTCTGAGAGTAGGAAATTTGGATACAAAAGCATAAGTCAGAAAGTGAAGGTCACCAATCCACCAACCCGAGAACCTACAGCT
GATGGTGCATTTCAGGCTTCTTCCACGGTCTGGCCTGGAACCCCACCCGGCTGGTGCAGGCATCAGATCAGGGTGTAGAAGTCACCCCAA
GCAAGAGGAAGCCAGGCAGTGAGGCCCTGGGGTGTGGCTGCAGCTGGGCCCACCTGTGCGGGGGTGGGAAGGCCCCATCCTCAGGGAGAG
GGCATCGGCGCCCTGACGTCAGCTCCACTGGGAGTGGCAGGAGCTGTGGGAGCCCATGGGTGAGGGACCCACCACCCCGCTGCACTGTGC
ATTGTGCCTCCCGTGTGGACGCCCTCTCTGTTGTTGGCCCGCGGGTGAGGGACCCACCACCCCTAGGGACCCACCACCCCGCCGCACTGT
GCATTCTGCCTCCTGTGTGGACGCCCTCTCTGTTGTCAGTGGCTTTGAGGTGTCAGTGCTTACTTAGATGCTGGTTTAATGCTGGACCCA
TTTGTTAAACGCACCTTCACTTTGTCAAAACCCAGGTTTGGTTGGCAGGACTGGGTCTTCTGCCCAATGCCAGGTGCCTGCGCCTCTCAG
TGGCCTGGTTCTTGGACAGTTTGCCCCCATGTGGCAGGGATAGGGATAAGGATCTCCTCTCAGTACTGGAAGAGAACAGCCAACCATCTG
AGCCCAGAGTCACAGATCCATCGTGGCCCCCTATGACCCCCAAGCCCTACCGAGGGGGCACTCACTCTCTGCTTAGCCAGGGGGCGTCTT
TCAAAAGGTGACCTCCATGCTGTGCTGTCGTGGGTGTGAGACGTGCTCATGGCCTTCCACTGCCATCTCTCCCTTATCTGATGCCTAAAG
TCACGATGGGGACAGAGCTACCCAGGGGCCAGCCATGGGGTGACCAGCCACCTGAGGGTCAGTCACCTGTGGAGAGCAGGCACCTGTGAA
GACCAGGCACCTGAGGACTGGCGCCTACTTCCCACTTTGGCCCTACACTGGCACAGAGCCCCTCTTTATTCATTTCTCATGCTGAGCATG
GCACACTTCTGGCCTCTGGGCATTTATGGATTTAAGACCAGGATGGTATTTCAGAAGCTTCCCACTTCCTTCCTATTCTAACCGAGTGCC
CAGCTCCTTTGCTGATCATGGAAAGACCCTTAATAATTAGGCCTGCAGGCCAGGCGCAGTGGCTCATGCCTATAATCCCAGCACTTTAGG
AGGTCAAGGTAGGAGGATCGCTTAAGCCCAGGAGTTCAAGACCAGCCTGGGCAACACAGGAAGAATGTGTCTCTACAAAAAATAATTAAA
AATCAGATCTGCTGTATCCCTGAAAAAGTCTCAATCAACATGCATGTTCCACTCTTGGAGTTCCCTGTTCTGAGGGCCAGCCACGTCCTG
TGTCCTGGAGCTTAGCCCTCAGCAGCTCCCTTCAGCCTGGGCGCCGCCTGGGTCCCAAACGTGGCAGCTGCTCTTCCAGTCTCGGGGCCG
AGGAGGGCAGGGAGCTCAGTGACTGAGAGTCTTGTGTATCACATGTCTTGAGTGTCCTGGAGCCAACGGCTGTCACTGGGAAAAACACCA
GGCCCCAAAGATCGAATCAGAGACGTGGCTGCGTGTTTGCGATTGTAGCCAGGCCCTTCAGTGTCATCAAAGGAGCACTGGGGCCTCCTT
AAGCACAGACGGCAGCCCCTGCCCAGGAGGCTTCTTCACCACGTCCTGCCCTGCAGCCTCCCAGACCTTTAGATGCGCCCCTGCCCAAGG
CCCTCCTGGTGACAGGTGCCAGATTGAGTGGTGGGTTGCTGCCAGGCAGGCCACGCTGTGTTGACGCTGCACTCAGCACGTGGGTGTTGG
CTCTGCCGGTTTTGTGGTGTGGGGACCCTACAGGAGGCTGCGGCCCTGAGAGCCTGGGATCAGCGAGGTGTCCGACATCCCTTCCTCAAC
GGCAACAAAAACTCCCCAAGTCAGCACTTTGGTTATTTTATAGCCACAACCCTCTTGGAAAACAGTGGGGAAGACTATGGAACATAGAAA
GTGTGGATGTATCACTTCTCTCTAAAATGTCATTGTTAGCACTAATTACAGGTTCATGTTTTTCTGTGTATGTAGCTTTTCCCTATATAG
CTGAAAAAGTATTAAAGTCAAATATAAGGTGGGAATGGGATGGAAGGGAGGAGATCAATACAACTTATATTTTTGCAGTTTCTACTGGAA
GAAAAAAGTTTTCAATACCTAGACCAACTTGTTGAATTTTTAAAACTTATGCACTATAAATGCAACTTTCTCTACTGCTTTCTCAGTGCC
TTTAGGAAGCTTTCAAATTTTTTTGTACTGTGGTTTGTATTAAATTTGCAATATTGATGTAAAATACATGACATGCTAGTACATGTTTAA

>52605_52605_5_MED15-AHRR_MED15_chr22_20909435_ENST00000406969_AHRR_chr5_376725_ENST00000316418_length(amino acids)=800AA_BP=106
LRRRRWRPSGIRAAGAGEQAWTFPGKRPTGGAPPSGRSCEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKS
QASVSDPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQIVQEQSSRQPAAGA
PSPGDSCPLAGSAVLEGRLLLESLNGFALVVSAEGTIFYASATIVDYLGFHQTDVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQVVFGQP
PPLETGDDAILGRLLRAQEWGTGTPTEYSAFLTRCFICRVRCLLDSTSGFLARGSQAWQLRLCCPEPLMTMQFQGKLKFLFGQKKKAPSG
AMLPPRLSLFCIAAPVLLPSAAEMKMRSALLRAKPRADTAATADAKVKATTSLCESELHGKPNYSAGRSSRESGVLVLREQTDAGRWAQV
PARAPCLCLRGGPDLVLDPKGGSGDREEEQHRMLSRASGVTGRRETPGPTKPLPWTAGKHSEDGARPRLQPSKNDPPSLRPMPRGSCLPC
PCVQGTFRNSPISHPPSPSPSAYSSRTSRPMRDVGEDQVHPPLCHFPQRSLQHQLPQPGAQRFATRGYPMEDMKLQGVPMPPGDLCGPTL
LLDVSIKMEKDSGCEGAADGCVPSQVWLGASDRSHPATFPTRMHLKTEPDSRQQVYISHLGHGVRGAQPHGRATAGRSRELTPFHPAHCA

--------------------------------------------------------------
>52605_52605_6_MED15-AHRR_MED15_chr22_20909435_ENST00000406969_AHRR_chr5_376725_ENST00000505113_length(transcript)=2374nt_BP=501nt
GACTGAGGCGGCGGCGGTGGCGGCCAAGCGGGATACGGGCGGCGGGAGCTGGGGAACAGGCATGGACGTTTCCGGGCAAGAGACCGACTG
GCGGAGCACCGCCTTCCGGCAGAAGCTGCGAGGATGCCATGAGGAAAGCTGGTGTGGCACACAGTAAATCCAGCAAGGATATGGAGAGCC
ATGTTTTCCTGAAGGCCAAGACCCGGGACGAATACCTTTCTCTCGTGGCCAGGCTCATTATCCATTTTCGAGACATTCATAACAAGAAAT
CTCAAGCTTCCGTCAGTGATCCTATGAATGCACTCCAGAGCCTGACTGGCGGACCTGCTGCGGGAGCCGCTGGAATTGGCATGCCTCCTC
GGGGCCCGGGACAGTCTCTGGGCGGGATGGGTAGCCTTGGTGCCATGGGACAGCCAATGTCTCTCTCAGGGCAGCCGCCTCCTGGGACCT
CGGGGATGGCCCCTCACAGCATGGCTGTCGTGTCTACGGCAACTCCACAGATCGTGCAGGAGCAGAGCTCACGGCAGCCTGCGGCCGGCG
CCCCCTCGCCCGGAGACAGCTGTCCTCTTGCAGGGTCTGCCGTGCTGGAGGGAAGGCTGCTGTTGGAGTCTCTTAATGGCTTTGCTCTGG
TCGTGAGTGCAGAAGGGACGATATTTTATGCATCAGCAACGATCGTGGACTATCTGGGCTTCCATCAGACGGATGTAATGCACCAGAACA
TTTATGACTACATCCACGTGGACGACCGCCAGGACTTCTGCCGGCAGCTCCACTGGGCCATGGACCCTCCCCAGGTGGTGTTTGGGCAGC
CCCCGCCCTTGGAGACAGGAGATGATGCTATCCTGGGGAGGCTGCTCAGGGCCCAGGAGTGGGGCACAGGCACGCCCACCGAGTACTCGG
CCTTCCTGACCCGCTGCTTCATCTGCCGTGTGCGCTGCCTGCTGGACAGCACCTCGGGCTTCCTGACGATGCAGTTTCAAGGAAAACTAA
AATTCCTGTTTGGACAGAAGAAGAAGGCGCCGTCAGGAGCCATGCTCCCGCCGCGGCTGTCGCTGTTCTGCATTGCGGCACCCGTTCTCC
TCCCCTCCGCAGCGGAGATGAAAATGAGGAGCGCGCTCCTGAGGGCAAAACCCAGAGCAGACACCGCAGCCACCGCGGATGCAAAAGTAA
AAGCCACCACCAGTCTGTGCGAATCGGAACTGCATGGAAAACCCAATTACTCAGCAGGAAGGAGCAGCAGAGAGAGCGGCGTTTTGGTGC
TCAGGGAACAGACTGACGCTGGCCGATGGGCACAGGTTCCCGCCAGGGCCCCATGCCTGTGCCTCCGGGGTGGCCCTGACCTTGTCCTTG
ACCCCAAGGGGGGCTCAGGGGACAGGGAGGAGGAGCAGCACAGGATGCTGAGCAGGGCCTCTGGAGTGACAGGGCGGAGGGAGACTCCAG
GACCCACAAAGCCCCTGCCCTGGACAGCGGGAAAGCACAGTGAGGATGGTGCCAGGCCGAGGCTGCAGCCCAGCAAGAATGACCCGCCCT
CCCTGCGCCCCATGCCCCGCGGCTCCTGCCTGCCCTGCCCGTGTGTCCAGGGCACTTTCAGGAACTCGCCCATCTCTCACCCGCCGAGCC
CGTCCCCCAGTGCCTACTCCAGCCGGACCAGCAGACCCATGCGGGATGTCGGTGAGGACCAGGTGCACCCTCCCCTCTGCCACTTTCCCC
AGAGGAGCCTGCAGCACCAGCTCCCTCAGCCTGGAGCTCAGCGTTTTGCCACGAGGGGCTATCCCATGGAGGACATGAAGCTGCAAGGTG
TACCGATGCCTCCGGGGGACCTGTGTGGTCCGACGCTGCTGCTAGATGTGTCCATCAAGATGGAGAAGGACTCTGGGTGTGAGGGTGCTG
CAGACGGCTGTGTGCCCAGCCAGGTGTGGCTGGGGGCCAGTGACAGGAGCCACCCAGCCACCTTCCCTACCAGGATGCACCTGAAAACAG
AGCCAGACTCTCGGCAACAGGTGTACATCTCGCACCTGGGGCACGGCGTGCGGGGGGCTCAGCCCCATGGGAGGGCCACTGCTGGGCGCA
GCAGGGAGCTGACCCCTTTCCACCCTGCACACTGTGCCTGCCTGGAGCCCACAGACGGCCTTCCCCAGTCGGAGCCTCCCCACCAGCTCT
GTGCACGGGGCCGAGGTGAACAGTCCTGCACCTGCAGAGCTGCTGAGGCCGCCCCTGTGGTCAAGCGGGAGCCCTTGGACTCACCCCAGT
GGGCTACTCACAGCCAGGGAATGGTGCCCGGGATGTTGCCCAAAAGTGCCTTGGCCACGCTGGTCCCGCCCCAAGCTTCGGGGTGCACAT

>52605_52605_6_MED15-AHRR_MED15_chr22_20909435_ENST00000406969_AHRR_chr5_376725_ENST00000505113_length(amino acids)=782AA_BP=106
LRRRRWRPSGIRAAGAGEQAWTFPGKRPTGGAPPSGRSCEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKS
QASVSDPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQIVQEQSSRQPAAGA
PSPGDSCPLAGSAVLEGRLLLESLNGFALVVSAEGTIFYASATIVDYLGFHQTDVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQVVFGQP
PPLETGDDAILGRLLRAQEWGTGTPTEYSAFLTRCFICRVRCLLDSTSGFLTMQFQGKLKFLFGQKKKAPSGAMLPPRLSLFCIAAPVLL
PSAAEMKMRSALLRAKPRADTAATADAKVKATTSLCESELHGKPNYSAGRSSRESGVLVLREQTDAGRWAQVPARAPCLCLRGGPDLVLD
PKGGSGDREEEQHRMLSRASGVTGRRETPGPTKPLPWTAGKHSEDGARPRLQPSKNDPPSLRPMPRGSCLPCPCVQGTFRNSPISHPPSP
SPSAYSSRTSRPMRDVGEDQVHPPLCHFPQRSLQHQLPQPGAQRFATRGYPMEDMKLQGVPMPPGDLCGPTLLLDVSIKMEKDSGCEGAA
DGCVPSQVWLGASDRSHPATFPTRMHLKTEPDSRQQVYISHLGHGVRGAQPHGRATAGRSRELTPFHPAHCACLEPTDGLPQSEPPHQLC

--------------------------------------------------------------
>52605_52605_7_MED15-AHRR_MED15_chr22_20909435_ENST00000541476_AHRR_chr5_376725_ENST00000316418_length(transcript)=6137nt_BP=776nt
ACACTGAATAGGGAAAGGGAGAGAAGCAGCCGGCTGTAGTGGGTTTAGCAGGGCTGGGTGCTTCATGGTTTCTCTTCCAGAAAAGCGCAT
CAACGGTGAAAGAAAGTGATGGGAGGAGGGTGGATGTAAGATGAGATTGGGAAGGTAGTTGTTTGGGGTGTGGGCGGTGGGACGGAGGAT
CTGAGGGTGACCCCCCGAAGGAATGTGGACTTTGCCGAAGGATGGCAGGAAGCCGCTGTCAGGAAGCGATCGTCGTTTCTGGAGGAGAGC
GTGAAGAGCTGGGGTCAGTGGCCCCGCTCAGAGGAACTCTAGCCCCTCACCACCGACTGCTTGTTTCTGTTAGCAGTTTTTTTCATGCGC
GTCCGTGTGAAGAGACCACCAAACAGGCTTTGTCGAGGATGCCATGAGGAAAGCTGGTGTGGCACACAGTAAATCCAGCAAGGATATGGA
GAGCCATGTTTTCCTGAAGGCCAAGACCCGGGACGAATACCTTTCTCTCGTGGCCAGGCTCATTATCCATTTTCGAGACATTCATAACAA
GAAATCTCAAGCTTCCGTCAGTGATCCTATGAATGCACTCCAGAGCCTGACTGGCGGACCTGCTGCGGGAGCCGCTGGAATTGGCATGCC
TCCTCGGGGCCCGGGACAGTCTCTGGGCGGGATGGGTAGCCTTGGTGCCATGGGACAGCCAATGTCTCTCTCAGGGCAGCCGCCTCCTGG
GACCTCGGGGATGGCCCCTCACAGCATGGCTGTCGTGTCTACGGCAACTCCACAGATCGTGCAGGAGCAGAGCTCACGGCAGCCTGCGGC
CGGCGCCCCCTCGCCCGGAGACAGCTGTCCTCTTGCAGGGTCTGCCGTGCTGGAGGGAAGGCTGCTGTTGGAGTCTCTTAATGGCTTTGC
TCTGGTCGTGAGTGCAGAAGGGACGATATTTTATGCATCAGCAACGATCGTGGACTATCTGGGCTTCCATCAGACGGATGTAATGCACCA
GAACATTTATGACTACATCCACGTGGACGACCGCCAGGACTTCTGCCGGCAGCTCCACTGGGCCATGGACCCTCCCCAGGTGGTGTTTGG
GCAGCCCCCGCCCTTGGAGACAGGAGATGATGCTATCCTGGGGAGGCTGCTCAGGGCCCAGGAGTGGGGCACAGGCACGCCCACCGAGTA
CTCGGCCTTCCTGACCCGCTGCTTCATCTGCCGTGTGCGCTGCCTGCTGGACAGCACCTCGGGCTTCCTGGCCCGGGGGTCACAGGCTTG
GCAGCTGCGGCTCTGCTGTCCCGAGCCACTCATGACGATGCAGTTTCAAGGAAAACTAAAATTCCTGTTTGGACAGAAGAAGAAGGCGCC
GTCAGGAGCCATGCTCCCGCCGCGGCTGTCGCTGTTCTGCATTGCGGCACCCGTTCTCCTCCCCTCCGCAGCGGAGATGAAAATGAGGAG
CGCGCTCCTGAGGGCAAAACCCAGAGCAGACACCGCAGCCACCGCGGATGCAAAAGTAAAAGCCACCACCAGTCTGTGCGAATCGGAACT
GCATGGAAAACCCAATTACTCAGCAGGAAGGAGCAGCAGAGAGAGCGGCGTTTTGGTGCTCAGGGAACAGACTGACGCTGGCCGATGGGC
ACAGGTTCCCGCCAGGGCCCCATGCCTGTGCCTCCGGGGTGGCCCTGACCTTGTCCTTGACCCCAAGGGGGGCTCAGGGGACAGGGAGGA
GGAGCAGCACAGGATGCTGAGCAGGGCCTCTGGAGTGACAGGGCGGAGGGAGACTCCAGGACCCACAAAGCCCCTGCCCTGGACAGCGGG
AAAGCACAGTGAGGATGGTGCCAGGCCGAGGCTGCAGCCCAGCAAGAATGACCCGCCCTCCCTGCGCCCCATGCCCCGCGGCTCCTGCCT
GCCCTGCCCGTGTGTCCAGGGCACTTTCAGGAACTCGCCCATCTCTCACCCGCCGAGCCCGTCCCCCAGTGCCTACTCCAGCCGGACCAG
CAGACCCATGCGGGATGTCGGTGAGGACCAGGTGCACCCTCCCCTCTGCCACTTTCCCCAGAGGAGCCTGCAGCACCAGCTCCCTCAGCC
TGGAGCTCAGCGTTTTGCCACGAGGGGCTATCCCATGGAGGACATGAAGCTGCAAGGTGTACCGATGCCTCCGGGGGACCTGTGTGGTCC
GACGCTGCTGCTAGATGTGTCCATCAAGATGGAGAAGGACTCTGGGTGTGAGGGTGCTGCAGACGGCTGTGTGCCCAGCCAGGTGTGGCT
GGGGGCCAGTGACAGGAGCCACCCAGCCACCTTCCCTACCAGGATGCACCTGAAAACAGAGCCAGACTCTCGGCAACAGGTGTACATCTC
GCACCTGGGGCACGGCGTGCGGGGGGCTCAGCCCCATGGGAGGGCCACTGCTGGGCGCAGCAGGGAGCTGACCCCTTTCCACCCTGCACA
CTGTGCCTGCCTGGAGCCCACAGACGGCCTTCCCCAGTCGGAGCCTCCCCACCAGCTCTGTGCACGGGGCCGAGGTGAACAGTCCTGCAC
CTGCAGAGCTGCTGAGGCCGCCCCTGTGGTCAAGCGGGAGCCCTTGGACTCACCCCAGTGGGCTACTCACAGCCAGGGAATGGTGCCCGG
GATGTTGCCCAAAAGTGCCTTGGCCACGCTGGTCCCGCCCCAAGCTTCGGGGTGCACATTCCTGCCATAGCGCAGTGACCACCATCCAAG
CTCAGATCTGTGTGTCTACGCTCAGATGCGTCGGTGGCTGGGCTGCCCTGCTCCTGGTCAGGCCGGAGCCCGTCCTAAGACACACGCTTT
GCAGAGCTGTGCATGCGCAGTCTGCTAGTGTGTGTGTGCAGCATACGCAGGAGCCTATCCTGAATTTTGTAAAATATCCCAACAGTTCTT
AAATGAAAACTGGCCTTAAGTCTATTCAAGCATGACAGCATTTCTCTTTGAGGAATTAAAATCTTTAGGAAAGTGATCATGGCTGGACAG
CTTCATGCCCCAGAGGCAGCGAGCACCCGTCCCATGGCTGCCAAGTCCACAGTCGGGGATGAAGCAGTCGGGTGATGCTCCCAAGTCCGC
AGTCGGGGATGAAGCGGTCGGGTGATGCTCCCAAGTCCGCAGTCGGGGATGAAGCGGTCGGGTGACACACCTAGCTCAGCCCTCCCAGGC
CACCTGCAGCTCCCAGCCTGTGCTGTGCAGGCAGGGTCAGCCCATCGCCACAGTGCACTGTAGAGGCCAGCACACGGCAAATTAGAAATA
CAACACGCGGAGAAAGGGGTCCGTGAGCCCACTCATAGAGGAATCTAGAACGTTCCAGGCAGCAGAGGCTGGCAGCGTGGGTCCCACACT
GCCCCACACCGTGCGGCAGGTGCTCCATGGCGCCATGACAGAGTCTGAGGCCAGACCTGGACTGGAATTGACAGCATAACCCCTGTTCCT
TCTGGACATCTCCCGAGTTCTCAGTGGGTCTCTGCGGACGGTTCTTCCTAATCTGCCTCTTGGTACATCACGTAATACAGAGTTCACAGA
CTCCGGGTTTGGAAGTACAGAGAAACACACAACGTAGAGAGAAGACACAGGAAACTGCGCTGCCTGTGGGGGTTTCTCTCTGGCTGGCTG
TACAGTTCACTCAAATGAGGGTTCCCATTGCCATCCTAGGAGAATAATTAGGGACAAGACAGACAAGTATTAATAGCATTAAAACAGTTG
TAAAGGCGATATTTTCTGAGAGTAGGAAATTTGGATACAAAAGCATAAGTCAGAAAGTGAAGGTCACCAATCCACCAACCCGAGAACCTA
CAGCTGATGGTGCATTTCAGGCTTCTTCCACGGTCTGGCCTGGAACCCCACCCGGCTGGTGCAGGCATCAGATCAGGGTGTAGAAGTCAC
CCCAAGCAAGAGGAAGCCAGGCAGTGAGGCCCTGGGGTGTGGCTGCAGCTGGGCCCACCTGTGCGGGGGTGGGAAGGCCCCATCCTCAGG
GAGAGGGCATCGGCGCCCTGACGTCAGCTCCACTGGGAGTGGCAGGAGCTGTGGGAGCCCATGGGTGAGGGACCCACCACCCCGCTGCAC
TGTGCATTGTGCCTCCCGTGTGGACGCCCTCTCTGTTGTTGGCCCGCGGGTGAGGGACCCACCACCCCTAGGGACCCACCACCCCGCCGC
ACTGTGCATTCTGCCTCCTGTGTGGACGCCCTCTCTGTTGTCAGTGGCTTTGAGGTGTCAGTGCTTACTTAGATGCTGGTTTAATGCTGG
ACCCATTTGTTAAACGCACCTTCACTTTGTCAAAACCCAGGTTTGGTTGGCAGGACTGGGTCTTCTGCCCAATGCCAGGTGCCTGCGCCT
CTCAGTGGCCTGGTTCTTGGACAGTTTGCCCCCATGTGGCAGGGATAGGGATAAGGATCTCCTCTCAGTACTGGAAGAGAACAGCCAACC
ATCTGAGCCCAGAGTCACAGATCCATCGTGGCCCCCTATGACCCCCAAGCCCTACCGAGGGGGCACTCACTCTCTGCTTAGCCAGGGGGC
GTCTTTCAAAAGGTGACCTCCATGCTGTGCTGTCGTGGGTGTGAGACGTGCTCATGGCCTTCCACTGCCATCTCTCCCTTATCTGATGCC
TAAAGTCACGATGGGGACAGAGCTACCCAGGGGCCAGCCATGGGGTGACCAGCCACCTGAGGGTCAGTCACCTGTGGAGAGCAGGCACCT
GTGAAGACCAGGCACCTGAGGACTGGCGCCTACTTCCCACTTTGGCCCTACACTGGCACAGAGCCCCTCTTTATTCATTTCTCATGCTGA
GCATGGCACACTTCTGGCCTCTGGGCATTTATGGATTTAAGACCAGGATGGTATTTCAGAAGCTTCCCACTTCCTTCCTATTCTAACCGA
GTGCCCAGCTCCTTTGCTGATCATGGAAAGACCCTTAATAATTAGGCCTGCAGGCCAGGCGCAGTGGCTCATGCCTATAATCCCAGCACT
TTAGGAGGTCAAGGTAGGAGGATCGCTTAAGCCCAGGAGTTCAAGACCAGCCTGGGCAACACAGGAAGAATGTGTCTCTACAAAAAATAA
TTAAAAATCAGATCTGCTGTATCCCTGAAAAAGTCTCAATCAACATGCATGTTCCACTCTTGGAGTTCCCTGTTCTGAGGGCCAGCCACG
TCCTGTGTCCTGGAGCTTAGCCCTCAGCAGCTCCCTTCAGCCTGGGCGCCGCCTGGGTCCCAAACGTGGCAGCTGCTCTTCCAGTCTCGG
GGCCGAGGAGGGCAGGGAGCTCAGTGACTGAGAGTCTTGTGTATCACATGTCTTGAGTGTCCTGGAGCCAACGGCTGTCACTGGGAAAAA
CACCAGGCCCCAAAGATCGAATCAGAGACGTGGCTGCGTGTTTGCGATTGTAGCCAGGCCCTTCAGTGTCATCAAAGGAGCACTGGGGCC
TCCTTAAGCACAGACGGCAGCCCCTGCCCAGGAGGCTTCTTCACCACGTCCTGCCCTGCAGCCTCCCAGACCTTTAGATGCGCCCCTGCC
CAAGGCCCTCCTGGTGACAGGTGCCAGATTGAGTGGTGGGTTGCTGCCAGGCAGGCCACGCTGTGTTGACGCTGCACTCAGCACGTGGGT
GTTGGCTCTGCCGGTTTTGTGGTGTGGGGACCCTACAGGAGGCTGCGGCCCTGAGAGCCTGGGATCAGCGAGGTGTCCGACATCCCTTCC
TCAACGGCAACAAAAACTCCCCAAGTCAGCACTTTGGTTATTTTATAGCCACAACCCTCTTGGAAAACAGTGGGGAAGACTATGGAACAT
AGAAAGTGTGGATGTATCACTTCTCTCTAAAATGTCATTGTTAGCACTAATTACAGGTTCATGTTTTTCTGTGTATGTAGCTTTTCCCTA
TATAGCTGAAAAAGTATTAAAGTCAAATATAAGGTGGGAATGGGATGGAAGGGAGGAGATCAATACAACTTATATTTTTGCAGTTTCTAC
TGGAAGAAAAAAGTTTTCAATACCTAGACCAACTTGTTGAATTTTTAAAACTTATGCACTATAAATGCAACTTTCTCTACTGCTTTCTCA
GTGCCTTTAGGAAGCTTTCAAATTTTTTTGTACTGTGGTTTGTATTAAATTTGCAATATTGATGTAAAATACATGACATGCTAGTACATG

>52605_52605_7_MED15-AHRR_MED15_chr22_20909435_ENST00000541476_AHRR_chr5_376725_ENST00000316418_length(amino acids)=758AA_BP=64
MRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSL
GAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQIVQEQSSRQPAAGAPSPGDSCPLAGSAVLEGRLLLESLNGFALVVSAEGTIFYASA
TIVDYLGFHQTDVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQVVFGQPPPLETGDDAILGRLLRAQEWGTGTPTEYSAFLTRCFICRVRC
LLDSTSGFLARGSQAWQLRLCCPEPLMTMQFQGKLKFLFGQKKKAPSGAMLPPRLSLFCIAAPVLLPSAAEMKMRSALLRAKPRADTAAT
ADAKVKATTSLCESELHGKPNYSAGRSSRESGVLVLREQTDAGRWAQVPARAPCLCLRGGPDLVLDPKGGSGDREEEQHRMLSRASGVTG
RRETPGPTKPLPWTAGKHSEDGARPRLQPSKNDPPSLRPMPRGSCLPCPCVQGTFRNSPISHPPSPSPSAYSSRTSRPMRDVGEDQVHPP
LCHFPQRSLQHQLPQPGAQRFATRGYPMEDMKLQGVPMPPGDLCGPTLLLDVSIKMEKDSGCEGAADGCVPSQVWLGASDRSHPATFPTR
MHLKTEPDSRQQVYISHLGHGVRGAQPHGRATAGRSRELTPFHPAHCACLEPTDGLPQSEPPHQLCARGRGEQSCTCRAAEAAPVVKREP

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>52605_52605_8_MED15-AHRR_MED15_chr22_20909435_ENST00000541476_AHRR_chr5_376725_ENST00000505113_length(transcript)=2649nt_BP=776nt
ACACTGAATAGGGAAAGGGAGAGAAGCAGCCGGCTGTAGTGGGTTTAGCAGGGCTGGGTGCTTCATGGTTTCTCTTCCAGAAAAGCGCAT
CAACGGTGAAAGAAAGTGATGGGAGGAGGGTGGATGTAAGATGAGATTGGGAAGGTAGTTGTTTGGGGTGTGGGCGGTGGGACGGAGGAT
CTGAGGGTGACCCCCCGAAGGAATGTGGACTTTGCCGAAGGATGGCAGGAAGCCGCTGTCAGGAAGCGATCGTCGTTTCTGGAGGAGAGC
GTGAAGAGCTGGGGTCAGTGGCCCCGCTCAGAGGAACTCTAGCCCCTCACCACCGACTGCTTGTTTCTGTTAGCAGTTTTTTTCATGCGC
GTCCGTGTGAAGAGACCACCAAACAGGCTTTGTCGAGGATGCCATGAGGAAAGCTGGTGTGGCACACAGTAAATCCAGCAAGGATATGGA
GAGCCATGTTTTCCTGAAGGCCAAGACCCGGGACGAATACCTTTCTCTCGTGGCCAGGCTCATTATCCATTTTCGAGACATTCATAACAA
GAAATCTCAAGCTTCCGTCAGTGATCCTATGAATGCACTCCAGAGCCTGACTGGCGGACCTGCTGCGGGAGCCGCTGGAATTGGCATGCC
TCCTCGGGGCCCGGGACAGTCTCTGGGCGGGATGGGTAGCCTTGGTGCCATGGGACAGCCAATGTCTCTCTCAGGGCAGCCGCCTCCTGG
GACCTCGGGGATGGCCCCTCACAGCATGGCTGTCGTGTCTACGGCAACTCCACAGATCGTGCAGGAGCAGAGCTCACGGCAGCCTGCGGC
CGGCGCCCCCTCGCCCGGAGACAGCTGTCCTCTTGCAGGGTCTGCCGTGCTGGAGGGAAGGCTGCTGTTGGAGTCTCTTAATGGCTTTGC
TCTGGTCGTGAGTGCAGAAGGGACGATATTTTATGCATCAGCAACGATCGTGGACTATCTGGGCTTCCATCAGACGGATGTAATGCACCA
GAACATTTATGACTACATCCACGTGGACGACCGCCAGGACTTCTGCCGGCAGCTCCACTGGGCCATGGACCCTCCCCAGGTGGTGTTTGG
GCAGCCCCCGCCCTTGGAGACAGGAGATGATGCTATCCTGGGGAGGCTGCTCAGGGCCCAGGAGTGGGGCACAGGCACGCCCACCGAGTA
CTCGGCCTTCCTGACCCGCTGCTTCATCTGCCGTGTGCGCTGCCTGCTGGACAGCACCTCGGGCTTCCTGACGATGCAGTTTCAAGGAAA
ACTAAAATTCCTGTTTGGACAGAAGAAGAAGGCGCCGTCAGGAGCCATGCTCCCGCCGCGGCTGTCGCTGTTCTGCATTGCGGCACCCGT
TCTCCTCCCCTCCGCAGCGGAGATGAAAATGAGGAGCGCGCTCCTGAGGGCAAAACCCAGAGCAGACACCGCAGCCACCGCGGATGCAAA
AGTAAAAGCCACCACCAGTCTGTGCGAATCGGAACTGCATGGAAAACCCAATTACTCAGCAGGAAGGAGCAGCAGAGAGAGCGGCGTTTT
GGTGCTCAGGGAACAGACTGACGCTGGCCGATGGGCACAGGTTCCCGCCAGGGCCCCATGCCTGTGCCTCCGGGGTGGCCCTGACCTTGT
CCTTGACCCCAAGGGGGGCTCAGGGGACAGGGAGGAGGAGCAGCACAGGATGCTGAGCAGGGCCTCTGGAGTGACAGGGCGGAGGGAGAC
TCCAGGACCCACAAAGCCCCTGCCCTGGACAGCGGGAAAGCACAGTGAGGATGGTGCCAGGCCGAGGCTGCAGCCCAGCAAGAATGACCC
GCCCTCCCTGCGCCCCATGCCCCGCGGCTCCTGCCTGCCCTGCCCGTGTGTCCAGGGCACTTTCAGGAACTCGCCCATCTCTCACCCGCC
GAGCCCGTCCCCCAGTGCCTACTCCAGCCGGACCAGCAGACCCATGCGGGATGTCGGTGAGGACCAGGTGCACCCTCCCCTCTGCCACTT
TCCCCAGAGGAGCCTGCAGCACCAGCTCCCTCAGCCTGGAGCTCAGCGTTTTGCCACGAGGGGCTATCCCATGGAGGACATGAAGCTGCA
AGGTGTACCGATGCCTCCGGGGGACCTGTGTGGTCCGACGCTGCTGCTAGATGTGTCCATCAAGATGGAGAAGGACTCTGGGTGTGAGGG
TGCTGCAGACGGCTGTGTGCCCAGCCAGGTGTGGCTGGGGGCCAGTGACAGGAGCCACCCAGCCACCTTCCCTACCAGGATGCACCTGAA
AACAGAGCCAGACTCTCGGCAACAGGTGTACATCTCGCACCTGGGGCACGGCGTGCGGGGGGCTCAGCCCCATGGGAGGGCCACTGCTGG
GCGCAGCAGGGAGCTGACCCCTTTCCACCCTGCACACTGTGCCTGCCTGGAGCCCACAGACGGCCTTCCCCAGTCGGAGCCTCCCCACCA
GCTCTGTGCACGGGGCCGAGGTGAACAGTCCTGCACCTGCAGAGCTGCTGAGGCCGCCCCTGTGGTCAAGCGGGAGCCCTTGGACTCACC
CCAGTGGGCTACTCACAGCCAGGGAATGGTGCCCGGGATGTTGCCCAAAAGTGCCTTGGCCACGCTGGTCCCGCCCCAAGCTTCGGGGTG

>52605_52605_8_MED15-AHRR_MED15_chr22_20909435_ENST00000541476_AHRR_chr5_376725_ENST00000505113_length(amino acids)=740AA_BP=64
MRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSL
GAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQIVQEQSSRQPAAGAPSPGDSCPLAGSAVLEGRLLLESLNGFALVVSAEGTIFYASA
TIVDYLGFHQTDVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQVVFGQPPPLETGDDAILGRLLRAQEWGTGTPTEYSAFLTRCFICRVRC
LLDSTSGFLTMQFQGKLKFLFGQKKKAPSGAMLPPRLSLFCIAAPVLLPSAAEMKMRSALLRAKPRADTAATADAKVKATTSLCESELHG
KPNYSAGRSSRESGVLVLREQTDAGRWAQVPARAPCLCLRGGPDLVLDPKGGSGDREEEQHRMLSRASGVTGRRETPGPTKPLPWTAGKH
SEDGARPRLQPSKNDPPSLRPMPRGSCLPCPCVQGTFRNSPISHPPSPSPSAYSSRTSRPMRDVGEDQVHPPLCHFPQRSLQHQLPQPGA
QRFATRGYPMEDMKLQGVPMPPGDLCGPTLLLDVSIKMEKDSGCEGAADGCVPSQVWLGASDRSHPATFPTRMHLKTEPDSRQQVYISHL
GHGVRGAQPHGRATAGRSRELTPFHPAHCACLEPTDGLPQSEPPHQLCARGRGEQSCTCRAAEAAPVVKREPLDSPQWATHSQGMVPGML

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Fusion Gene PPI Analysis for MED15-AHRR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneMED15chr22:20909435chr5:376725ENST00000263205+5189_73150.33333333333334789.0SREBF1
HgeneMED15chr22:20909435chr5:376725ENST00000292733+5179_73150.33333333333334749.0SREBF1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMED15chr22:20909435chr5:376725ENST00000382974+1169_730678.0SREBF1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MED15-AHRR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MED15-AHRR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource