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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MED15-LYZ (FusionGDB2 ID:52617)

Fusion Gene Summary for MED15-LYZ

check button Fusion gene summary
Fusion gene informationFusion gene name: MED15-LYZ
Fusion gene ID: 52617
HgeneTgene
Gene symbol

MED15

LYZ

Gene ID

51586

4069

Gene namemediator complex subunit 15lysozyme
SynonymsARC105|CAG7A|CTG7A|PCQAP|TIG-1|TIG1|TNRC7LYZF1|LZM
Cytomap

22q11.21

12q15

Type of geneprotein-codingprotein-coding
Descriptionmediator of RNA polymerase II transcription subunit 15CTG repeat protein 7aPC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated proteinPC2 glutamine/Q-rich-associated proteinPC2-glutamine-rich-associated proteinTPA inducible gelysozyme C1,4-beta-N-acetylmuramidase Cc-type lysozymelysozyme F1
Modification date2020031320200313
UniProtAcc

Q96RN5

P61626

Ensembl transtripts involved in fusion geneENST00000263205, ENST00000292733, 
ENST00000382974, ENST00000406969, 
ENST00000425759, ENST00000541476, 
ENST00000478831, ENST00000542773, 
ENST00000548839, ENST00000261267, 
ENST00000549690, 
Fusion gene scores* DoF score17 X 11 X 9=168351 X 27 X 13=17901
# samples 2060
** MAII scorelog2(20/1683*10)=-3.07296327155522
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(60/17901*10)=-4.89893387178018
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MED15 [Title/Abstract] AND LYZ [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMED15(20905774)-LYZ(69743888), # samples:1
Anticipated loss of major functional domain due to fusion event.MED15-LYZ seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLYZ

GO:0031640

killing of cells of other organism

9727055

TgeneLYZ

GO:0042742

defense response to bacterium

21093056

TgeneLYZ

GO:0050830

defense response to Gram-positive bacterium

21093056


check buttonFusion gene breakpoints across MED15 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LYZ (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GH-01AMED15chr22

20905774

+LYZchr12

69743888

+


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Fusion Gene ORF analysis for MED15-LYZ

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000263205ENST00000548839MED15chr22

20905774

+LYZchr12

69743888

+
Frame-shiftENST00000292733ENST00000548839MED15chr22

20905774

+LYZchr12

69743888

+
Frame-shiftENST00000382974ENST00000548839MED15chr22

20905774

+LYZchr12

69743888

+
Frame-shiftENST00000406969ENST00000548839MED15chr22

20905774

+LYZchr12

69743888

+
Frame-shiftENST00000425759ENST00000548839MED15chr22

20905774

+LYZchr12

69743888

+
Frame-shiftENST00000541476ENST00000548839MED15chr22

20905774

+LYZchr12

69743888

+
In-frameENST00000263205ENST00000261267MED15chr22

20905774

+LYZchr12

69743888

+
In-frameENST00000263205ENST00000549690MED15chr22

20905774

+LYZchr12

69743888

+
In-frameENST00000292733ENST00000261267MED15chr22

20905774

+LYZchr12

69743888

+
In-frameENST00000292733ENST00000549690MED15chr22

20905774

+LYZchr12

69743888

+
In-frameENST00000382974ENST00000261267MED15chr22

20905774

+LYZchr12

69743888

+
In-frameENST00000382974ENST00000549690MED15chr22

20905774

+LYZchr12

69743888

+
In-frameENST00000406969ENST00000261267MED15chr22

20905774

+LYZchr12

69743888

+
In-frameENST00000406969ENST00000549690MED15chr22

20905774

+LYZchr12

69743888

+
In-frameENST00000425759ENST00000261267MED15chr22

20905774

+LYZchr12

69743888

+
In-frameENST00000425759ENST00000549690MED15chr22

20905774

+LYZchr12

69743888

+
In-frameENST00000541476ENST00000261267MED15chr22

20905774

+LYZchr12

69743888

+
In-frameENST00000541476ENST00000549690MED15chr22

20905774

+LYZchr12

69743888

+
intron-3CDSENST00000478831ENST00000261267MED15chr22

20905774

+LYZchr12

69743888

+
intron-3CDSENST00000478831ENST00000548839MED15chr22

20905774

+LYZchr12

69743888

+
intron-3CDSENST00000478831ENST00000549690MED15chr22

20905774

+LYZchr12

69743888

+
intron-3CDSENST00000542773ENST00000261267MED15chr22

20905774

+LYZchr12

69743888

+
intron-3CDSENST00000542773ENST00000548839MED15chr22

20905774

+LYZchr12

69743888

+
intron-3CDSENST00000542773ENST00000549690MED15chr22

20905774

+LYZchr12

69743888

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000425759MED15chr2220905774+ENST00000261267LYZchr1269743888+161428880598172
ENST00000425759MED15chr2220905774+ENST00000549690LYZchr1269743888+79628880565161
ENST00000292733MED15chr2220905774+ENST00000261267LYZchr1269743888+161128577595172
ENST00000292733MED15chr2220905774+ENST00000549690LYZchr1269743888+79328577562161
ENST00000263205MED15chr2220905774+ENST00000261267LYZchr1269743888+160327769587172
ENST00000263205MED15chr2220905774+ENST00000549690LYZchr1269743888+78527769554161
ENST00000406969MED15chr2220905774+ENST00000261267LYZchr1269743888+15842582568188
ENST00000406969MED15chr2220905774+ENST00000549690LYZchr1269743888+7662582535177
ENST00000382974MED15chr2220905774+ENST00000261267LYZchr1269743888+157224638556172
ENST00000382974MED15chr2220905774+ENST00000549690LYZchr1269743888+75424638523161
ENST00000541476MED15chr2220905774+ENST00000261267LYZchr1269743888+1859533403843146
ENST00000541476MED15chr2220905774+ENST00000549690LYZchr1269743888+1041533403810135

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000425759ENST00000261267MED15chr2220905774+LYZchr1269743888+0.0078628270.99213713
ENST00000425759ENST00000549690MED15chr2220905774+LYZchr1269743888+0.0285833050.9714167
ENST00000292733ENST00000261267MED15chr2220905774+LYZchr1269743888+0.0075629580.99243706
ENST00000292733ENST00000549690MED15chr2220905774+LYZchr1269743888+0.027395540.9726044
ENST00000263205ENST00000261267MED15chr2220905774+LYZchr1269743888+0.0073157830.9926842
ENST00000263205ENST00000549690MED15chr2220905774+LYZchr1269743888+0.028192180.9718078
ENST00000406969ENST00000261267MED15chr2220905774+LYZchr1269743888+0.0116972260.98830277
ENST00000406969ENST00000549690MED15chr2220905774+LYZchr1269743888+0.0455145460.9544855
ENST00000382974ENST00000261267MED15chr2220905774+LYZchr1269743888+0.0077377460.99226224
ENST00000382974ENST00000549690MED15chr2220905774+LYZchr1269743888+0.031252210.9687478
ENST00000541476ENST00000261267MED15chr2220905774+LYZchr1269743888+0.0175847320.98241526
ENST00000541476ENST00000549690MED15chr2220905774+LYZchr1269743888+0.0779659150.9220341

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Fusion Genomic Features for MED15-LYZ


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MED15-LYZ


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:20905774/chr12:69743888)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MED15

Q96RN5

LYZ

P61626

FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway. {ECO:0000269|PubMed:12167862, ECO:0000269|PubMed:16630888, ECO:0000269|PubMed:16799563}.FUNCTION: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMED15chr22:20905774chr12:69743888ENST00000263205+318161_17469789.0Compositional biasNote=Poly-Gln
HgeneMED15chr22:20905774chr12:69743888ENST00000263205+318178_19369789.0Compositional biasNote=Poly-Gln
HgeneMED15chr22:20905774chr12:69743888ENST00000263205+318205_21869789.0Compositional biasNote=Poly-Gln
HgeneMED15chr22:20905774chr12:69743888ENST00000263205+318226_23969789.0Compositional biasNote=Poly-Gln
HgeneMED15chr22:20905774chr12:69743888ENST00000263205+318243_26269789.0Compositional biasNote=Poly-Gln
HgeneMED15chr22:20905774chr12:69743888ENST00000263205+318266_51569789.0Compositional biasNote=Pro-rich
HgeneMED15chr22:20905774chr12:69743888ENST00000263205+318360_36769789.0Compositional biasNote=Poly-Gln
HgeneMED15chr22:20905774chr12:69743888ENST00000263205+318449_45669789.0Compositional biasNote=Poly-Pro
HgeneMED15chr22:20905774chr12:69743888ENST00000263205+318602_61169789.0Compositional biasNote=Poly-Pro
HgeneMED15chr22:20905774chr12:69743888ENST00000292733+317161_17469749.0Compositional biasNote=Poly-Gln
HgeneMED15chr22:20905774chr12:69743888ENST00000292733+317178_19369749.0Compositional biasNote=Poly-Gln
HgeneMED15chr22:20905774chr12:69743888ENST00000292733+317205_21869749.0Compositional biasNote=Poly-Gln
HgeneMED15chr22:20905774chr12:69743888ENST00000292733+317226_23969749.0Compositional biasNote=Poly-Gln
HgeneMED15chr22:20905774chr12:69743888ENST00000292733+317243_26269749.0Compositional biasNote=Poly-Gln
HgeneMED15chr22:20905774chr12:69743888ENST00000292733+317266_51569749.0Compositional biasNote=Pro-rich
HgeneMED15chr22:20905774chr12:69743888ENST00000292733+317360_36769749.0Compositional biasNote=Poly-Gln
HgeneMED15chr22:20905774chr12:69743888ENST00000292733+317449_45669749.0Compositional biasNote=Poly-Pro
HgeneMED15chr22:20905774chr12:69743888ENST00000292733+317602_61169749.0Compositional biasNote=Poly-Pro
HgeneMED15chr22:20905774chr12:69743888ENST00000382974+316161_17469678.0Compositional biasNote=Poly-Gln
HgeneMED15chr22:20905774chr12:69743888ENST00000382974+316178_19369678.0Compositional biasNote=Poly-Gln
HgeneMED15chr22:20905774chr12:69743888ENST00000382974+316205_21869678.0Compositional biasNote=Poly-Gln
HgeneMED15chr22:20905774chr12:69743888ENST00000382974+316226_23969678.0Compositional biasNote=Poly-Gln
HgeneMED15chr22:20905774chr12:69743888ENST00000382974+316243_26269678.0Compositional biasNote=Poly-Gln
HgeneMED15chr22:20905774chr12:69743888ENST00000382974+316266_51569678.0Compositional biasNote=Pro-rich
HgeneMED15chr22:20905774chr12:69743888ENST00000382974+316360_36769678.0Compositional biasNote=Poly-Gln
HgeneMED15chr22:20905774chr12:69743888ENST00000382974+316449_45669678.0Compositional biasNote=Poly-Pro
HgeneMED15chr22:20905774chr12:69743888ENST00000382974+316602_61169678.0Compositional biasNote=Poly-Pro
HgeneMED15chr22:20905774chr12:69743888ENST00000263205+318547_56469789.0MotifNuclear localization signal
HgeneMED15chr22:20905774chr12:69743888ENST00000292733+317547_56469749.0MotifNuclear localization signal
HgeneMED15chr22:20905774chr12:69743888ENST00000382974+316547_56469678.0MotifNuclear localization signal
TgeneLYZchr22:20905774chr12:69743888ENST000002612670419_14845149.0DomainC-type lysozyme


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Fusion Gene Sequence for MED15-LYZ


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>52617_52617_1_MED15-LYZ_MED15_chr22_20905774_ENST00000263205_LYZ_chr12_69743888_ENST00000261267_length(transcript)=1603nt_BP=277nt
GGCTCTGTGACTGAGGCGGCGGCGGTGGCGGCCAAGCGGGATACGGGCGGCGGGAGCTGGGGAACAGGCATGGACGTTTCCGGGCAAGAG
ACCGACTGGCGGAGCACCGCCTTCCGGCAGAAGCTGGTCAGTCAAATCGAGGATGCCATGAGGAAAGCTGGTGTGGCACACAGTAAATCC
AGCAAGGATATGGAGAGCCATGTTTTCCTGAAGGCCAAGACCCGGGACGAATACCTTTCTCTCGTGGCCAGGCTCATTATCCATTTTCGA
GACATTCGGATGTGTTTGGCCAAATGGGAGAGTGGTTACAACACACGAGCTACAAACTACAATGCTGGAGACAGAAGCACTGATTATGGG
ATATTTCAGATCAATAGCCGCTACTGGTGTAATGATGGCAAAACCCCAGGAGCAGTTAATGCCTGTCATTTATCCTGCAGTGCTTTGCTG
CAAGATAACATCGCTGATGCTGTAGCTTGTGCAAAGAGGGTTGTCCGTGATCCACAAGGCATTAGAGCATGGGTGGCATGGAGAAATCGT
TGTCAAAACAGAGATGTCCGTCAGTATGTTCAAGGTTGTGGAGTGTAACTCCAGAATTTTCCTTCTTCAGCTCATTTTGTCTCTCTCACA
TTAAGGGAGTAGGAATTAAGTGAAAGGTCACACTACCATTATTTCCCCTTCAAACAAATAATATTTTTACAGAAGCAGGAGCAAAATATG
GCCTTTCTTCTAAGAGATATAATGTTCACTAATGTGGTTATTTTACATTAAGCCTACAACATTTTTCAGTTTGCAAATAGAACTAATACT
GGTGAAAATTTACCTAAAACCTTGGTTATCAAATACATCTCCAGTACATTCCGTTCTTTTTTTTTTTGAGACAGTCTCGCTCTGTCGCCC
AGGCTGGAGTGCAGTGGCGCAATCTCGGCTCACTGCAACCTCCACCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCT
GGGATTACGGGCGCCCGCCACCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCGTGTTAGCCAGGATGGTCTCGA
TCTCCTGACCTTGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCACATTCAGTTCTTA
TCAAAGAAATAACCCAGACTTAATCTTGAATGATACGATTATGCCCAATATTAAGTAAAAAATATAAGAAAAGGTTATCTTAAATAGATC
TTAGGCAAAATACCAGCTGATGAAGGCATCTGATGCCTTCATCTGTTCAGTCATCTCCAAAAACAGTAAAAATAACCACTTTTTGTTGGG
CAATATGAAATTTTTAAAGGAGTAGAATACCAAATGATAGAAACAGACTGCCTGAATTGAGAATTTTGATTTCTTAAAGTGTGTTTCTTT
CTAAATTGCTGTTCCTTAATTTGATTAATTTAATTCATGTATTATGATTAAATCTGAGGCAGATGAGCTTACAAGTATTGAAATAATTAC

>52617_52617_1_MED15-LYZ_MED15_chr22_20905774_ENST00000263205_LYZ_chr12_69743888_ENST00000261267_length(amino acids)=172AA_BP=70
MDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIRMCLAKWESGYNTRATNYNAG

--------------------------------------------------------------
>52617_52617_2_MED15-LYZ_MED15_chr22_20905774_ENST00000263205_LYZ_chr12_69743888_ENST00000549690_length(transcript)=785nt_BP=277nt
GGCTCTGTGACTGAGGCGGCGGCGGTGGCGGCCAAGCGGGATACGGGCGGCGGGAGCTGGGGAACAGGCATGGACGTTTCCGGGCAAGAG
ACCGACTGGCGGAGCACCGCCTTCCGGCAGAAGCTGGTCAGTCAAATCGAGGATGCCATGAGGAAAGCTGGTGTGGCACACAGTAAATCC
AGCAAGGATATGGAGAGCCATGTTTTCCTGAAGGCCAAGACCCGGGACGAATACCTTTCTCTCGTGGCCAGGCTCATTATCCATTTTCGA
GACATTCGGATGTGTTTGGCCAAATGGGAGAGTGGTTACAACACACGAGCTACAAACTACAATGCTGGAGACAGAAGCACTGATTATGGG
ATATTTCAGATCAATAGCCGCTACTGGTGTAATGATGGCAAAACCCCAGGAGCAGTTAATGCCTGTCATTTATCCTGCAGTGGGTGGCAT
GGAGAAATCGTTGTCAAAACAGAGATGTCCGTCAGTATGTTCAAGGTTGTGGAGTGTAACTCCAGAATTTTCCTTCTTCAGCTCATTTTG
TCTCTCTCACATTAAGGGAGTAGGAATTAAGTGAAAGGTCACACTACCATTATTTCCCCTTCAAACAAATAATATTTTTACAGAAGCAGG
AGCAAAATATGGCCTTTCTTCTAAGAGATATAATGTTCACTAATGTGGTTATTTTACATTAAGCCTACAACATTTTTCAGTTTGCAAATA

>52617_52617_2_MED15-LYZ_MED15_chr22_20905774_ENST00000263205_LYZ_chr12_69743888_ENST00000549690_length(amino acids)=161AA_BP=70
MDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIRMCLAKWESGYNTRATNYNAG

--------------------------------------------------------------
>52617_52617_3_MED15-LYZ_MED15_chr22_20905774_ENST00000292733_LYZ_chr12_69743888_ENST00000261267_length(transcript)=1611nt_BP=285nt
TTGGGCCTGGCTCTGTGACTGAGGCGGCGGCGGTGGCGGCCAAGCGGGATACGGGCGGCGGGAGCTGGGGAACAGGCATGGACGTTTCCG
GGCAAGAGACCGACTGGCGGAGCACCGCCTTCCGGCAGAAGCTGGTCAGTCAAATCGAGGATGCCATGAGGAAAGCTGGTGTGGCACACA
GTAAATCCAGCAAGGATATGGAGAGCCATGTTTTCCTGAAGGCCAAGACCCGGGACGAATACCTTTCTCTCGTGGCCAGGCTCATTATCC
ATTTTCGAGACATTCGGATGTGTTTGGCCAAATGGGAGAGTGGTTACAACACACGAGCTACAAACTACAATGCTGGAGACAGAAGCACTG
ATTATGGGATATTTCAGATCAATAGCCGCTACTGGTGTAATGATGGCAAAACCCCAGGAGCAGTTAATGCCTGTCATTTATCCTGCAGTG
CTTTGCTGCAAGATAACATCGCTGATGCTGTAGCTTGTGCAAAGAGGGTTGTCCGTGATCCACAAGGCATTAGAGCATGGGTGGCATGGA
GAAATCGTTGTCAAAACAGAGATGTCCGTCAGTATGTTCAAGGTTGTGGAGTGTAACTCCAGAATTTTCCTTCTTCAGCTCATTTTGTCT
CTCTCACATTAAGGGAGTAGGAATTAAGTGAAAGGTCACACTACCATTATTTCCCCTTCAAACAAATAATATTTTTACAGAAGCAGGAGC
AAAATATGGCCTTTCTTCTAAGAGATATAATGTTCACTAATGTGGTTATTTTACATTAAGCCTACAACATTTTTCAGTTTGCAAATAGAA
CTAATACTGGTGAAAATTTACCTAAAACCTTGGTTATCAAATACATCTCCAGTACATTCCGTTCTTTTTTTTTTTGAGACAGTCTCGCTC
TGTCGCCCAGGCTGGAGTGCAGTGGCGCAATCTCGGCTCACTGCAACCTCCACCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCC
GAGTAGCTGGGATTACGGGCGCCCGCCACCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCGTGTTAGCCAGGAT
GGTCTCGATCTCCTGACCTTGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCACATTC
AGTTCTTATCAAAGAAATAACCCAGACTTAATCTTGAATGATACGATTATGCCCAATATTAAGTAAAAAATATAAGAAAAGGTTATCTTA
AATAGATCTTAGGCAAAATACCAGCTGATGAAGGCATCTGATGCCTTCATCTGTTCAGTCATCTCCAAAAACAGTAAAAATAACCACTTT
TTGTTGGGCAATATGAAATTTTTAAAGGAGTAGAATACCAAATGATAGAAACAGACTGCCTGAATTGAGAATTTTGATTTCTTAAAGTGT
GTTTCTTTCTAAATTGCTGTTCCTTAATTTGATTAATTTAATTCATGTATTATGATTAAATCTGAGGCAGATGAGCTTACAAGTATTGAA

>52617_52617_3_MED15-LYZ_MED15_chr22_20905774_ENST00000292733_LYZ_chr12_69743888_ENST00000261267_length(amino acids)=172AA_BP=70
MDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIRMCLAKWESGYNTRATNYNAG

--------------------------------------------------------------
>52617_52617_4_MED15-LYZ_MED15_chr22_20905774_ENST00000292733_LYZ_chr12_69743888_ENST00000549690_length(transcript)=793nt_BP=285nt
TTGGGCCTGGCTCTGTGACTGAGGCGGCGGCGGTGGCGGCCAAGCGGGATACGGGCGGCGGGAGCTGGGGAACAGGCATGGACGTTTCCG
GGCAAGAGACCGACTGGCGGAGCACCGCCTTCCGGCAGAAGCTGGTCAGTCAAATCGAGGATGCCATGAGGAAAGCTGGTGTGGCACACA
GTAAATCCAGCAAGGATATGGAGAGCCATGTTTTCCTGAAGGCCAAGACCCGGGACGAATACCTTTCTCTCGTGGCCAGGCTCATTATCC
ATTTTCGAGACATTCGGATGTGTTTGGCCAAATGGGAGAGTGGTTACAACACACGAGCTACAAACTACAATGCTGGAGACAGAAGCACTG
ATTATGGGATATTTCAGATCAATAGCCGCTACTGGTGTAATGATGGCAAAACCCCAGGAGCAGTTAATGCCTGTCATTTATCCTGCAGTG
GGTGGCATGGAGAAATCGTTGTCAAAACAGAGATGTCCGTCAGTATGTTCAAGGTTGTGGAGTGTAACTCCAGAATTTTCCTTCTTCAGC
TCATTTTGTCTCTCTCACATTAAGGGAGTAGGAATTAAGTGAAAGGTCACACTACCATTATTTCCCCTTCAAACAAATAATATTTTTACA
GAAGCAGGAGCAAAATATGGCCTTTCTTCTAAGAGATATAATGTTCACTAATGTGGTTATTTTACATTAAGCCTACAACATTTTTCAGTT

>52617_52617_4_MED15-LYZ_MED15_chr22_20905774_ENST00000292733_LYZ_chr12_69743888_ENST00000549690_length(amino acids)=161AA_BP=70
MDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIRMCLAKWESGYNTRATNYNAG

--------------------------------------------------------------
>52617_52617_5_MED15-LYZ_MED15_chr22_20905774_ENST00000382974_LYZ_chr12_69743888_ENST00000261267_length(transcript)=1572nt_BP=246nt
CCAAGCGGGATACGGGCGGCGGGAGCTGGGGAACAGGCATGGACGTTTCCGGGCAAGAGACCGACTGGCGGAGCACCGCCTTCCGGCAGA
AGCTGGTCAGTCAAATCGAGGATGCCATGAGGAAAGCTGGTGTGGCACACAGTAAATCCAGCAAGGATATGGAGAGCCATGTTTTCCTGA
AGGCCAAGACCCGGGACGAATACCTTTCTCTCGTGGCCAGGCTCATTATCCATTTTCGAGACATTCGGATGTGTTTGGCCAAATGGGAGA
GTGGTTACAACACACGAGCTACAAACTACAATGCTGGAGACAGAAGCACTGATTATGGGATATTTCAGATCAATAGCCGCTACTGGTGTA
ATGATGGCAAAACCCCAGGAGCAGTTAATGCCTGTCATTTATCCTGCAGTGCTTTGCTGCAAGATAACATCGCTGATGCTGTAGCTTGTG
CAAAGAGGGTTGTCCGTGATCCACAAGGCATTAGAGCATGGGTGGCATGGAGAAATCGTTGTCAAAACAGAGATGTCCGTCAGTATGTTC
AAGGTTGTGGAGTGTAACTCCAGAATTTTCCTTCTTCAGCTCATTTTGTCTCTCTCACATTAAGGGAGTAGGAATTAAGTGAAAGGTCAC
ACTACCATTATTTCCCCTTCAAACAAATAATATTTTTACAGAAGCAGGAGCAAAATATGGCCTTTCTTCTAAGAGATATAATGTTCACTA
ATGTGGTTATTTTACATTAAGCCTACAACATTTTTCAGTTTGCAAATAGAACTAATACTGGTGAAAATTTACCTAAAACCTTGGTTATCA
AATACATCTCCAGTACATTCCGTTCTTTTTTTTTTTGAGACAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCAATCTCGGCTC
ACTGCAACCTCCACCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACGGGCGCCCGCCACCACGCCCGGC
TAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCCACCCACCTCGGC
CTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCACATTCAGTTCTTATCAAAGAAATAACCCAGACTTAATCTTGAAT
GATACGATTATGCCCAATATTAAGTAAAAAATATAAGAAAAGGTTATCTTAAATAGATCTTAGGCAAAATACCAGCTGATGAAGGCATCT
GATGCCTTCATCTGTTCAGTCATCTCCAAAAACAGTAAAAATAACCACTTTTTGTTGGGCAATATGAAATTTTTAAAGGAGTAGAATACC
AAATGATAGAAACAGACTGCCTGAATTGAGAATTTTGATTTCTTAAAGTGTGTTTCTTTCTAAATTGCTGTTCCTTAATTTGATTAATTT
AATTCATGTATTATGATTAAATCTGAGGCAGATGAGCTTACAAGTATTGAAATAATTACTAATTAATCACAAATGTGAAGTTATGCATGA

>52617_52617_5_MED15-LYZ_MED15_chr22_20905774_ENST00000382974_LYZ_chr12_69743888_ENST00000261267_length(amino acids)=172AA_BP=70
MDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIRMCLAKWESGYNTRATNYNAG

--------------------------------------------------------------
>52617_52617_6_MED15-LYZ_MED15_chr22_20905774_ENST00000382974_LYZ_chr12_69743888_ENST00000549690_length(transcript)=754nt_BP=246nt
CCAAGCGGGATACGGGCGGCGGGAGCTGGGGAACAGGCATGGACGTTTCCGGGCAAGAGACCGACTGGCGGAGCACCGCCTTCCGGCAGA
AGCTGGTCAGTCAAATCGAGGATGCCATGAGGAAAGCTGGTGTGGCACACAGTAAATCCAGCAAGGATATGGAGAGCCATGTTTTCCTGA
AGGCCAAGACCCGGGACGAATACCTTTCTCTCGTGGCCAGGCTCATTATCCATTTTCGAGACATTCGGATGTGTTTGGCCAAATGGGAGA
GTGGTTACAACACACGAGCTACAAACTACAATGCTGGAGACAGAAGCACTGATTATGGGATATTTCAGATCAATAGCCGCTACTGGTGTA
ATGATGGCAAAACCCCAGGAGCAGTTAATGCCTGTCATTTATCCTGCAGTGGGTGGCATGGAGAAATCGTTGTCAAAACAGAGATGTCCG
TCAGTATGTTCAAGGTTGTGGAGTGTAACTCCAGAATTTTCCTTCTTCAGCTCATTTTGTCTCTCTCACATTAAGGGAGTAGGAATTAAG
TGAAAGGTCACACTACCATTATTTCCCCTTCAAACAAATAATATTTTTACAGAAGCAGGAGCAAAATATGGCCTTTCTTCTAAGAGATAT
AATGTTCACTAATGTGGTTATTTTACATTAAGCCTACAACATTTTTCAGTTTGCAAATAGAACTAATACTGGTGAAAATTTACCTAAAAC

>52617_52617_6_MED15-LYZ_MED15_chr22_20905774_ENST00000382974_LYZ_chr12_69743888_ENST00000549690_length(amino acids)=161AA_BP=70
MDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIRMCLAKWESGYNTRATNYNAG

--------------------------------------------------------------
>52617_52617_7_MED15-LYZ_MED15_chr22_20905774_ENST00000406969_LYZ_chr12_69743888_ENST00000261267_length(transcript)=1584nt_BP=258nt
GACTGAGGCGGCGGCGGTGGCGGCCAAGCGGGATACGGGCGGCGGGAGCTGGGGAACAGGCATGGACGTTTCCGGGCAAGAGACCGACTG
GCGGAGCACCGCCTTCCGGCAGAAGCTGCGAGGATGCCATGAGGAAAGCTGGTGTGGCACACAGTAAATCCAGCAAGGATATGGAGAGCC
ATGTTTTCCTGAAGGCCAAGACCCGGGACGAATACCTTTCTCTCGTGGCCAGGCTCATTATCCATTTTCGAGACATTCGGATGTGTTTGG
CCAAATGGGAGAGTGGTTACAACACACGAGCTACAAACTACAATGCTGGAGACAGAAGCACTGATTATGGGATATTTCAGATCAATAGCC
GCTACTGGTGTAATGATGGCAAAACCCCAGGAGCAGTTAATGCCTGTCATTTATCCTGCAGTGCTTTGCTGCAAGATAACATCGCTGATG
CTGTAGCTTGTGCAAAGAGGGTTGTCCGTGATCCACAAGGCATTAGAGCATGGGTGGCATGGAGAAATCGTTGTCAAAACAGAGATGTCC
GTCAGTATGTTCAAGGTTGTGGAGTGTAACTCCAGAATTTTCCTTCTTCAGCTCATTTTGTCTCTCTCACATTAAGGGAGTAGGAATTAA
GTGAAAGGTCACACTACCATTATTTCCCCTTCAAACAAATAATATTTTTACAGAAGCAGGAGCAAAATATGGCCTTTCTTCTAAGAGATA
TAATGTTCACTAATGTGGTTATTTTACATTAAGCCTACAACATTTTTCAGTTTGCAAATAGAACTAATACTGGTGAAAATTTACCTAAAA
CCTTGGTTATCAAATACATCTCCAGTACATTCCGTTCTTTTTTTTTTTGAGACAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCG
CAATCTCGGCTCACTGCAACCTCCACCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACGGGCGCCCGCC
ACCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCC
ACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCACATTCAGTTCTTATCAAAGAAATAACCCAGAC
TTAATCTTGAATGATACGATTATGCCCAATATTAAGTAAAAAATATAAGAAAAGGTTATCTTAAATAGATCTTAGGCAAAATACCAGCTG
ATGAAGGCATCTGATGCCTTCATCTGTTCAGTCATCTCCAAAAACAGTAAAAATAACCACTTTTTGTTGGGCAATATGAAATTTTTAAAG
GAGTAGAATACCAAATGATAGAAACAGACTGCCTGAATTGAGAATTTTGATTTCTTAAAGTGTGTTTCTTTCTAAATTGCTGTTCCTTAA
TTTGATTAATTTAATTCATGTATTATGATTAAATCTGAGGCAGATGAGCTTACAAGTATTGAAATAATTACTAATTAATCACAAATGTGA

>52617_52617_7_MED15-LYZ_MED15_chr22_20905774_ENST00000406969_LYZ_chr12_69743888_ENST00000261267_length(amino acids)=188AA_BP=86
LRRRRWRPSGIRAAGAGEQAWTFPGKRPTGGAPPSGRSCEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIRMCLA
KWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVR

--------------------------------------------------------------
>52617_52617_8_MED15-LYZ_MED15_chr22_20905774_ENST00000406969_LYZ_chr12_69743888_ENST00000549690_length(transcript)=766nt_BP=258nt
GACTGAGGCGGCGGCGGTGGCGGCCAAGCGGGATACGGGCGGCGGGAGCTGGGGAACAGGCATGGACGTTTCCGGGCAAGAGACCGACTG
GCGGAGCACCGCCTTCCGGCAGAAGCTGCGAGGATGCCATGAGGAAAGCTGGTGTGGCACACAGTAAATCCAGCAAGGATATGGAGAGCC
ATGTTTTCCTGAAGGCCAAGACCCGGGACGAATACCTTTCTCTCGTGGCCAGGCTCATTATCCATTTTCGAGACATTCGGATGTGTTTGG
CCAAATGGGAGAGTGGTTACAACACACGAGCTACAAACTACAATGCTGGAGACAGAAGCACTGATTATGGGATATTTCAGATCAATAGCC
GCTACTGGTGTAATGATGGCAAAACCCCAGGAGCAGTTAATGCCTGTCATTTATCCTGCAGTGGGTGGCATGGAGAAATCGTTGTCAAAA
CAGAGATGTCCGTCAGTATGTTCAAGGTTGTGGAGTGTAACTCCAGAATTTTCCTTCTTCAGCTCATTTTGTCTCTCTCACATTAAGGGA
GTAGGAATTAAGTGAAAGGTCACACTACCATTATTTCCCCTTCAAACAAATAATATTTTTACAGAAGCAGGAGCAAAATATGGCCTTTCT
TCTAAGAGATATAATGTTCACTAATGTGGTTATTTTACATTAAGCCTACAACATTTTTCAGTTTGCAAATAGAACTAATACTGGTGAAAA

>52617_52617_8_MED15-LYZ_MED15_chr22_20905774_ENST00000406969_LYZ_chr12_69743888_ENST00000549690_length(amino acids)=177AA_BP=86
LRRRRWRPSGIRAAGAGEQAWTFPGKRPTGGAPPSGRSCEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIRMCLA

--------------------------------------------------------------
>52617_52617_9_MED15-LYZ_MED15_chr22_20905774_ENST00000425759_LYZ_chr12_69743888_ENST00000261267_length(transcript)=1614nt_BP=288nt
GGTTTGGGCCTGGCTCTGTGACTGAGGCGGCGGCGGTGGCGGCCAAGCGGGATACGGGCGGCGGGAGCTGGGGAACAGGCATGGACGTTT
CCGGGCAAGAGACCGACTGGCGGAGCACCGCCTTCCGGCAGAAGCTGGTCAGTCAAATCGAGGATGCCATGAGGAAAGCTGGTGTGGCAC
ACAGTAAATCCAGCAAGGATATGGAGAGCCATGTTTTCCTGAAGGCCAAGACCCGGGACGAATACCTTTCTCTCGTGGCCAGGCTCATTA
TCCATTTTCGAGACATTCGGATGTGTTTGGCCAAATGGGAGAGTGGTTACAACACACGAGCTACAAACTACAATGCTGGAGACAGAAGCA
CTGATTATGGGATATTTCAGATCAATAGCCGCTACTGGTGTAATGATGGCAAAACCCCAGGAGCAGTTAATGCCTGTCATTTATCCTGCA
GTGCTTTGCTGCAAGATAACATCGCTGATGCTGTAGCTTGTGCAAAGAGGGTTGTCCGTGATCCACAAGGCATTAGAGCATGGGTGGCAT
GGAGAAATCGTTGTCAAAACAGAGATGTCCGTCAGTATGTTCAAGGTTGTGGAGTGTAACTCCAGAATTTTCCTTCTTCAGCTCATTTTG
TCTCTCTCACATTAAGGGAGTAGGAATTAAGTGAAAGGTCACACTACCATTATTTCCCCTTCAAACAAATAATATTTTTACAGAAGCAGG
AGCAAAATATGGCCTTTCTTCTAAGAGATATAATGTTCACTAATGTGGTTATTTTACATTAAGCCTACAACATTTTTCAGTTTGCAAATA
GAACTAATACTGGTGAAAATTTACCTAAAACCTTGGTTATCAAATACATCTCCAGTACATTCCGTTCTTTTTTTTTTTGAGACAGTCTCG
CTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCAATCTCGGCTCACTGCAACCTCCACCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCT
CCCGAGTAGCTGGGATTACGGGCGCCCGCCACCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCGTGTTAGCCAG
GATGGTCTCGATCTCCTGACCTTGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCACA
TTCAGTTCTTATCAAAGAAATAACCCAGACTTAATCTTGAATGATACGATTATGCCCAATATTAAGTAAAAAATATAAGAAAAGGTTATC
TTAAATAGATCTTAGGCAAAATACCAGCTGATGAAGGCATCTGATGCCTTCATCTGTTCAGTCATCTCCAAAAACAGTAAAAATAACCAC
TTTTTGTTGGGCAATATGAAATTTTTAAAGGAGTAGAATACCAAATGATAGAAACAGACTGCCTGAATTGAGAATTTTGATTTCTTAAAG
TGTGTTTCTTTCTAAATTGCTGTTCCTTAATTTGATTAATTTAATTCATGTATTATGATTAAATCTGAGGCAGATGAGCTTACAAGTATT

>52617_52617_9_MED15-LYZ_MED15_chr22_20905774_ENST00000425759_LYZ_chr12_69743888_ENST00000261267_length(amino acids)=172AA_BP=70
MDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIRMCLAKWESGYNTRATNYNAG

--------------------------------------------------------------
>52617_52617_10_MED15-LYZ_MED15_chr22_20905774_ENST00000425759_LYZ_chr12_69743888_ENST00000549690_length(transcript)=796nt_BP=288nt
GGTTTGGGCCTGGCTCTGTGACTGAGGCGGCGGCGGTGGCGGCCAAGCGGGATACGGGCGGCGGGAGCTGGGGAACAGGCATGGACGTTT
CCGGGCAAGAGACCGACTGGCGGAGCACCGCCTTCCGGCAGAAGCTGGTCAGTCAAATCGAGGATGCCATGAGGAAAGCTGGTGTGGCAC
ACAGTAAATCCAGCAAGGATATGGAGAGCCATGTTTTCCTGAAGGCCAAGACCCGGGACGAATACCTTTCTCTCGTGGCCAGGCTCATTA
TCCATTTTCGAGACATTCGGATGTGTTTGGCCAAATGGGAGAGTGGTTACAACACACGAGCTACAAACTACAATGCTGGAGACAGAAGCA
CTGATTATGGGATATTTCAGATCAATAGCCGCTACTGGTGTAATGATGGCAAAACCCCAGGAGCAGTTAATGCCTGTCATTTATCCTGCA
GTGGGTGGCATGGAGAAATCGTTGTCAAAACAGAGATGTCCGTCAGTATGTTCAAGGTTGTGGAGTGTAACTCCAGAATTTTCCTTCTTC
AGCTCATTTTGTCTCTCTCACATTAAGGGAGTAGGAATTAAGTGAAAGGTCACACTACCATTATTTCCCCTTCAAACAAATAATATTTTT
ACAGAAGCAGGAGCAAAATATGGCCTTTCTTCTAAGAGATATAATGTTCACTAATGTGGTTATTTTACATTAAGCCTACAACATTTTTCA

>52617_52617_10_MED15-LYZ_MED15_chr22_20905774_ENST00000425759_LYZ_chr12_69743888_ENST00000549690_length(amino acids)=161AA_BP=70
MDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIRMCLAKWESGYNTRATNYNAG

--------------------------------------------------------------
>52617_52617_11_MED15-LYZ_MED15_chr22_20905774_ENST00000541476_LYZ_chr12_69743888_ENST00000261267_length(transcript)=1859nt_BP=533nt
ACACTGAATAGGGAAAGGGAGAGAAGCAGCCGGCTGTAGTGGGTTTAGCAGGGCTGGGTGCTTCATGGTTTCTCTTCCAGAAAAGCGCAT
CAACGGTGAAAGAAAGTGATGGGAGGAGGGTGGATGTAAGATGAGATTGGGAAGGTAGTTGTTTGGGGTGTGGGCGGTGGGACGGAGGAT
CTGAGGGTGACCCCCCGAAGGAATGTGGACTTTGCCGAAGGATGGCAGGAAGCCGCTGTCAGGAAGCGATCGTCGTTTCTGGAGGAGAGC
GTGAAGAGCTGGGGTCAGTGGCCCCGCTCAGAGGAACTCTAGCCCCTCACCACCGACTGCTTGTTTCTGTTAGCAGTTTTTTTCATGCGC
GTCCGTGTGAAGAGACCACCAAACAGGCTTTGTCGAGGATGCCATGAGGAAAGCTGGTGTGGCACACAGTAAATCCAGCAAGGATATGGA
GAGCCATGTTTTCCTGAAGGCCAAGACCCGGGACGAATACCTTTCTCTCGTGGCCAGGCTCATTATCCATTTTCGAGACATTCGGATGTG
TTTGGCCAAATGGGAGAGTGGTTACAACACACGAGCTACAAACTACAATGCTGGAGACAGAAGCACTGATTATGGGATATTTCAGATCAA
TAGCCGCTACTGGTGTAATGATGGCAAAACCCCAGGAGCAGTTAATGCCTGTCATTTATCCTGCAGTGCTTTGCTGCAAGATAACATCGC
TGATGCTGTAGCTTGTGCAAAGAGGGTTGTCCGTGATCCACAAGGCATTAGAGCATGGGTGGCATGGAGAAATCGTTGTCAAAACAGAGA
TGTCCGTCAGTATGTTCAAGGTTGTGGAGTGTAACTCCAGAATTTTCCTTCTTCAGCTCATTTTGTCTCTCTCACATTAAGGGAGTAGGA
ATTAAGTGAAAGGTCACACTACCATTATTTCCCCTTCAAACAAATAATATTTTTACAGAAGCAGGAGCAAAATATGGCCTTTCTTCTAAG
AGATATAATGTTCACTAATGTGGTTATTTTACATTAAGCCTACAACATTTTTCAGTTTGCAAATAGAACTAATACTGGTGAAAATTTACC
TAAAACCTTGGTTATCAAATACATCTCCAGTACATTCCGTTCTTTTTTTTTTTGAGACAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAG
TGGCGCAATCTCGGCTCACTGCAACCTCCACCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACGGGCGC
CCGCCACCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTTGT
GATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCACATTCAGTTCTTATCAAAGAAATAACC
CAGACTTAATCTTGAATGATACGATTATGCCCAATATTAAGTAAAAAATATAAGAAAAGGTTATCTTAAATAGATCTTAGGCAAAATACC
AGCTGATGAAGGCATCTGATGCCTTCATCTGTTCAGTCATCTCCAAAAACAGTAAAAATAACCACTTTTTGTTGGGCAATATGAAATTTT
TAAAGGAGTAGAATACCAAATGATAGAAACAGACTGCCTGAATTGAGAATTTTGATTTCTTAAAGTGTGTTTCTTTCTAAATTGCTGTTC
CTTAATTTGATTAATTTAATTCATGTATTATGATTAAATCTGAGGCAGATGAGCTTACAAGTATTGAAATAATTACTAATTAATCACAAA

>52617_52617_11_MED15-LYZ_MED15_chr22_20905774_ENST00000541476_LYZ_chr12_69743888_ENST00000261267_length(amino acids)=146AA_BP=44
MRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIRMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAV

--------------------------------------------------------------
>52617_52617_12_MED15-LYZ_MED15_chr22_20905774_ENST00000541476_LYZ_chr12_69743888_ENST00000549690_length(transcript)=1041nt_BP=533nt
ACACTGAATAGGGAAAGGGAGAGAAGCAGCCGGCTGTAGTGGGTTTAGCAGGGCTGGGTGCTTCATGGTTTCTCTTCCAGAAAAGCGCAT
CAACGGTGAAAGAAAGTGATGGGAGGAGGGTGGATGTAAGATGAGATTGGGAAGGTAGTTGTTTGGGGTGTGGGCGGTGGGACGGAGGAT
CTGAGGGTGACCCCCCGAAGGAATGTGGACTTTGCCGAAGGATGGCAGGAAGCCGCTGTCAGGAAGCGATCGTCGTTTCTGGAGGAGAGC
GTGAAGAGCTGGGGTCAGTGGCCCCGCTCAGAGGAACTCTAGCCCCTCACCACCGACTGCTTGTTTCTGTTAGCAGTTTTTTTCATGCGC
GTCCGTGTGAAGAGACCACCAAACAGGCTTTGTCGAGGATGCCATGAGGAAAGCTGGTGTGGCACACAGTAAATCCAGCAAGGATATGGA
GAGCCATGTTTTCCTGAAGGCCAAGACCCGGGACGAATACCTTTCTCTCGTGGCCAGGCTCATTATCCATTTTCGAGACATTCGGATGTG
TTTGGCCAAATGGGAGAGTGGTTACAACACACGAGCTACAAACTACAATGCTGGAGACAGAAGCACTGATTATGGGATATTTCAGATCAA
TAGCCGCTACTGGTGTAATGATGGCAAAACCCCAGGAGCAGTTAATGCCTGTCATTTATCCTGCAGTGGGTGGCATGGAGAAATCGTTGT
CAAAACAGAGATGTCCGTCAGTATGTTCAAGGTTGTGGAGTGTAACTCCAGAATTTTCCTTCTTCAGCTCATTTTGTCTCTCTCACATTA
AGGGAGTAGGAATTAAGTGAAAGGTCACACTACCATTATTTCCCCTTCAAACAAATAATATTTTTACAGAAGCAGGAGCAAAATATGGCC
TTTCTTCTAAGAGATATAATGTTCACTAATGTGGTTATTTTACATTAAGCCTACAACATTTTTCAGTTTGCAAATAGAACTAATACTGGT

>52617_52617_12_MED15-LYZ_MED15_chr22_20905774_ENST00000541476_LYZ_chr12_69743888_ENST00000549690_length(amino acids)=135AA_BP=44
MRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIRMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MED15-LYZ


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMED15chr22:20905774chr12:69743888ENST00000263205+3189_7369.33333333333333789.0SREBF1
HgeneMED15chr22:20905774chr12:69743888ENST00000292733+3179_7369.33333333333333749.0SREBF1
HgeneMED15chr22:20905774chr12:69743888ENST00000382974+3169_7369.33333333333333678.0SREBF1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MED15-LYZ


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MED15-LYZ


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource