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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MED15-TRIM40 (FusionGDB2 ID:52626)

Fusion Gene Summary for MED15-TRIM40

check button Fusion gene summary
Fusion gene informationFusion gene name: MED15-TRIM40
Fusion gene ID: 52626
HgeneTgene
Gene symbol

MED15

TRIM40

Gene ID

51586

135644

Gene namemediator complex subunit 15tripartite motif containing 40
SynonymsARC105|CAG7A|CTG7A|PCQAP|TIG-1|TIG1|TNRC7RNF35
Cytomap

22q11.21

6p22.1

Type of geneprotein-codingprotein-coding
Descriptionmediator of RNA polymerase II transcription subunit 15CTG repeat protein 7aPC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated proteinPC2 glutamine/Q-rich-associated proteinPC2-glutamine-rich-associated proteinTPA inducible getripartite motif-containing protein 40RING finger protein 35probable E3 NEDD8-protein ligasering finger RNF35
Modification date2020031320200313
UniProtAcc

Q96RN5

.
Ensembl transtripts involved in fusion geneENST00000263205, ENST00000292733, 
ENST00000382974, ENST00000406969, 
ENST00000425759, ENST00000478831, 
ENST00000541476, ENST00000542773, 
ENST00000307859, ENST00000376724, 
ENST00000383610, ENST00000396581, 
ENST00000400651, ENST00000418267, 
ENST00000421981, ENST00000425845, 
ENST00000429471, ENST00000430485, 
ENST00000431397, ENST00000433713, 
ENST00000434151, ENST00000436951, 
ENST00000437563, ENST00000445004, 
ENST00000456884, ENST00000462556, 
ENST00000470577, ENST00000475016, 
ENST00000476094, ENST00000486552, 
ENST00000488232, ENST00000489892, 
ENST00000497688, ENST00000547289, 
ENST00000548672, ENST00000549728, 
ENST00000552119, 
Fusion gene scores* DoF score17 X 11 X 9=16833 X 4 X 3=36
# samples 204
** MAII scorelog2(20/1683*10)=-3.07296327155522
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MED15 [Title/Abstract] AND TRIM40 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMED15(20928959)-TRIM40(30114985), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTRIM40

GO:0032088

negative regulation of NF-kappaB transcription factor activity

21474709

TgeneTRIM40

GO:0042177

negative regulation of protein catabolic process

21474709

TgeneTRIM40

GO:0045116

protein neddylation

21474709

TgeneTRIM40

GO:1900181

negative regulation of protein localization to nucleus

21474709


check buttonFusion gene breakpoints across MED15 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TRIM40 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABF991563MED15chr22

20928959

+TRIM40chr6

30114985

-


Top

Fusion Gene ORF analysis for MED15-TRIM40

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000263205ENST00000307859MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000263205ENST00000376724MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000263205ENST00000383610MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000263205ENST00000396581MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000263205ENST00000400651MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000263205ENST00000418267MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000263205ENST00000421981MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000263205ENST00000425845MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000263205ENST00000429471MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000263205ENST00000430485MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000263205ENST00000431397MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000263205ENST00000433713MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000263205ENST00000434151MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000263205ENST00000436951MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000263205ENST00000437563MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000263205ENST00000445004MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000263205ENST00000456884MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000263205ENST00000462556MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000263205ENST00000470577MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000263205ENST00000475016MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000263205ENST00000476094MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000263205ENST00000486552MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000263205ENST00000488232MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000263205ENST00000489892MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000263205ENST00000497688MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000263205ENST00000547289MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000263205ENST00000548672MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000263205ENST00000549728MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000263205ENST00000552119MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000292733ENST00000307859MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000292733ENST00000376724MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000292733ENST00000383610MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000292733ENST00000396581MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000292733ENST00000400651MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000292733ENST00000418267MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000292733ENST00000421981MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000292733ENST00000425845MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000292733ENST00000429471MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000292733ENST00000430485MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000292733ENST00000431397MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000292733ENST00000433713MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000292733ENST00000434151MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000292733ENST00000436951MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000292733ENST00000437563MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000292733ENST00000445004MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000292733ENST00000456884MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000292733ENST00000462556MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000292733ENST00000470577MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000292733ENST00000475016MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000292733ENST00000476094MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000292733ENST00000486552MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000292733ENST00000488232MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000292733ENST00000489892MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000292733ENST00000497688MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000292733ENST00000547289MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000292733ENST00000548672MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000292733ENST00000549728MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000292733ENST00000552119MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000382974ENST00000307859MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000382974ENST00000376724MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000382974ENST00000383610MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000382974ENST00000396581MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000382974ENST00000400651MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000382974ENST00000418267MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000382974ENST00000421981MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000382974ENST00000425845MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000382974ENST00000429471MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000382974ENST00000430485MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000382974ENST00000431397MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000382974ENST00000433713MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000382974ENST00000434151MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000382974ENST00000436951MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000382974ENST00000437563MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000382974ENST00000445004MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000382974ENST00000456884MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000382974ENST00000462556MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000382974ENST00000470577MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000382974ENST00000475016MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000382974ENST00000476094MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000382974ENST00000486552MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000382974ENST00000488232MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000382974ENST00000489892MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000382974ENST00000497688MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000382974ENST00000547289MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000382974ENST00000548672MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000382974ENST00000549728MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000382974ENST00000552119MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000406969ENST00000307859MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000406969ENST00000376724MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000406969ENST00000383610MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000406969ENST00000396581MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000406969ENST00000400651MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000406969ENST00000418267MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000406969ENST00000421981MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000406969ENST00000425845MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000406969ENST00000429471MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000406969ENST00000430485MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000406969ENST00000431397MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000406969ENST00000433713MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000406969ENST00000434151MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000406969ENST00000436951MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000406969ENST00000437563MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000406969ENST00000445004MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000406969ENST00000456884MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000406969ENST00000462556MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000406969ENST00000470577MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000406969ENST00000475016MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000406969ENST00000476094MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000406969ENST00000486552MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000406969ENST00000488232MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000406969ENST00000489892MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000406969ENST00000497688MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000406969ENST00000547289MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000406969ENST00000548672MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000406969ENST00000549728MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000406969ENST00000552119MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000425759ENST00000307859MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000425759ENST00000376724MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000425759ENST00000383610MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000425759ENST00000396581MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000425759ENST00000400651MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000425759ENST00000418267MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000425759ENST00000421981MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000425759ENST00000425845MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000425759ENST00000429471MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000425759ENST00000430485MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000425759ENST00000431397MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000425759ENST00000433713MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000425759ENST00000434151MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000425759ENST00000436951MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000425759ENST00000437563MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000425759ENST00000445004MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000425759ENST00000456884MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000425759ENST00000462556MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000425759ENST00000470577MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000425759ENST00000475016MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000425759ENST00000476094MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000425759ENST00000486552MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000425759ENST00000488232MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000425759ENST00000489892MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000425759ENST00000497688MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000425759ENST00000547289MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000425759ENST00000548672MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000425759ENST00000549728MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000425759ENST00000552119MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000478831ENST00000307859MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000478831ENST00000376724MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000478831ENST00000383610MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000478831ENST00000396581MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000478831ENST00000400651MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000478831ENST00000418267MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000478831ENST00000421981MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000478831ENST00000425845MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000478831ENST00000429471MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000478831ENST00000430485MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000478831ENST00000431397MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000478831ENST00000433713MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000478831ENST00000434151MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000478831ENST00000436951MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000478831ENST00000437563MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000478831ENST00000445004MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000478831ENST00000456884MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000478831ENST00000462556MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000478831ENST00000470577MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000478831ENST00000475016MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000478831ENST00000476094MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000478831ENST00000486552MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000478831ENST00000488232MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000478831ENST00000489892MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000478831ENST00000497688MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000478831ENST00000547289MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000478831ENST00000548672MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000478831ENST00000549728MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000478831ENST00000552119MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000541476ENST00000307859MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000541476ENST00000376724MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000541476ENST00000383610MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000541476ENST00000396581MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000541476ENST00000400651MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000541476ENST00000418267MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000541476ENST00000421981MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000541476ENST00000425845MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000541476ENST00000429471MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000541476ENST00000430485MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000541476ENST00000431397MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000541476ENST00000433713MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000541476ENST00000434151MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000541476ENST00000436951MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000541476ENST00000437563MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000541476ENST00000445004MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000541476ENST00000456884MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000541476ENST00000462556MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000541476ENST00000470577MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000541476ENST00000475016MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000541476ENST00000476094MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000541476ENST00000486552MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000541476ENST00000488232MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000541476ENST00000489892MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000541476ENST00000497688MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000541476ENST00000547289MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000541476ENST00000548672MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000541476ENST00000549728MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000541476ENST00000552119MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000542773ENST00000307859MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000542773ENST00000376724MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000542773ENST00000383610MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000542773ENST00000396581MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000542773ENST00000400651MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000542773ENST00000418267MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000542773ENST00000421981MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000542773ENST00000425845MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000542773ENST00000429471MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000542773ENST00000430485MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000542773ENST00000431397MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000542773ENST00000433713MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000542773ENST00000434151MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000542773ENST00000436951MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000542773ENST00000437563MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000542773ENST00000445004MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000542773ENST00000456884MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000542773ENST00000462556MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000542773ENST00000470577MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000542773ENST00000475016MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000542773ENST00000476094MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000542773ENST00000486552MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000542773ENST00000488232MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000542773ENST00000489892MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000542773ENST00000497688MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000542773ENST00000547289MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000542773ENST00000548672MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000542773ENST00000549728MED15chr22

20928959

+TRIM40chr6

30114985

-
intron-intronENST00000542773ENST00000552119MED15chr22

20928959

+TRIM40chr6

30114985

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MED15-TRIM40


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MED15-TRIM40


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:20928959/:30114985)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MED15

Q96RN5

.
FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway. {ECO:0000269|PubMed:12167862, ECO:0000269|PubMed:16630888, ECO:0000269|PubMed:16799563}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MED15-TRIM40


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MED15-TRIM40


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MED15-TRIM40


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MED15-TRIM40


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource