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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MED1-GSDMB (FusionGDB2 ID:52653)

Fusion Gene Summary for MED1-GSDMB

check button Fusion gene summary
Fusion gene informationFusion gene name: MED1-GSDMB
Fusion gene ID: 52653
HgeneTgene
Gene symbol

MED1

GSDMB

Gene ID

8930

55876

Gene namemethyl-CpG binding domain 4, DNA glycosylasegasdermin B
SynonymsMED1GSDMB-1|GSDML|PP4052|PRO2521
Cytomap

3q21.3

17q21.1

Type of geneprotein-codingprotein-coding
Descriptionmethyl-CpG-binding domain protein 43,N(4)-ethenocytosine glycosylaseG/5-fluorouracil mismatch glycosylase with biphasic kineticsG/T mismatch glycosylaseG/U mismatch glycosylasemethyl-CpG binding domain protein 4methyl-CpG-binding endonuclease 1methgasdermin-Bgasdermin-like proteingasderminB-1
Modification date2020031320200313
UniProtAcc

Q15648

Q8TAX9

Ensembl transtripts involved in fusion geneENST00000300651, ENST00000394287, 
ENST00000309481, ENST00000394175, 
ENST00000394179, ENST00000418519, 
ENST00000520542, ENST00000360317, 
Fusion gene scores* DoF score42 X 23 X 11=1062612 X 13 X 9=1404
# samples 4115
** MAII scorelog2(41/10626*10)=-4.69583089796762
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1404*10)=-3.22650852980868
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MED1 [Title/Abstract] AND GSDMB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMED1(37575970)-GSDMB(38062524), # samples:4
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MED1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GSDMB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-5B-A90C-01AMED1chr17

37575969

-GSDMBchr17

38062523

-
ChimerDB4UCECTCGA-5B-A90C-01AMED1chr17

37575969

-GSDMBchr17

38063239

-
ChimerDB4UCECTCGA-5B-A90C-01AMED1chr17

37575970

-GSDMBchr17

38062524

-
ChimerDB4UCECTCGA-5B-A90C-01AMED1chr17

37575970

-GSDMBchr17

38063240

-
ChimerDB4UCECTCGA-5B-A90CMED1chr17

37575969

-GSDMBchr17

38062524

-
ChimerDB4UCECTCGA-5B-A90CMED1chr17

37575970

-GSDMBchr17

38062524

-
ChimerDB4UCECTCGA-5B-A90CMED1chr17

37575970

-GSDMBchr17

38063240

-


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Fusion Gene ORF analysis for MED1-GSDMB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000300651ENST00000309481MED1chr17

37575969

-GSDMBchr17

38063239

-
5CDS-intronENST00000300651ENST00000309481MED1chr17

37575970

-GSDMBchr17

38063240

-
5CDS-intronENST00000300651ENST00000394175MED1chr17

37575969

-GSDMBchr17

38063239

-
5CDS-intronENST00000300651ENST00000394175MED1chr17

37575970

-GSDMBchr17

38063240

-
5CDS-intronENST00000300651ENST00000394179MED1chr17

37575969

-GSDMBchr17

38063239

-
5CDS-intronENST00000300651ENST00000394179MED1chr17

37575970

-GSDMBchr17

38063240

-
5CDS-intronENST00000300651ENST00000418519MED1chr17

37575969

-GSDMBchr17

38063239

-
5CDS-intronENST00000300651ENST00000418519MED1chr17

37575970

-GSDMBchr17

38063240

-
5CDS-intronENST00000300651ENST00000520542MED1chr17

37575969

-GSDMBchr17

38063239

-
5CDS-intronENST00000300651ENST00000520542MED1chr17

37575970

-GSDMBchr17

38063240

-
5CDS-intronENST00000394287ENST00000309481MED1chr17

37575969

-GSDMBchr17

38063239

-
5CDS-intronENST00000394287ENST00000309481MED1chr17

37575970

-GSDMBchr17

38063240

-
5CDS-intronENST00000394287ENST00000394175MED1chr17

37575969

-GSDMBchr17

38063239

-
5CDS-intronENST00000394287ENST00000394175MED1chr17

37575970

-GSDMBchr17

38063240

-
5CDS-intronENST00000394287ENST00000394179MED1chr17

37575969

-GSDMBchr17

38063239

-
5CDS-intronENST00000394287ENST00000394179MED1chr17

37575970

-GSDMBchr17

38063240

-
5CDS-intronENST00000394287ENST00000418519MED1chr17

37575969

-GSDMBchr17

38063239

-
5CDS-intronENST00000394287ENST00000418519MED1chr17

37575970

-GSDMBchr17

38063240

-
5CDS-intronENST00000394287ENST00000520542MED1chr17

37575969

-GSDMBchr17

38063239

-
5CDS-intronENST00000394287ENST00000520542MED1chr17

37575970

-GSDMBchr17

38063240

-
In-frameENST00000300651ENST00000309481MED1chr17

37575969

-GSDMBchr17

38062523

-
In-frameENST00000300651ENST00000309481MED1chr17

37575970

-GSDMBchr17

38062524

-
In-frameENST00000300651ENST00000309481MED1chr17

37575969

-GSDMBchr17

38062524

-
In-frameENST00000300651ENST00000360317MED1chr17

37575969

-GSDMBchr17

38062523

-
In-frameENST00000300651ENST00000360317MED1chr17

37575969

-GSDMBchr17

38063239

-
In-frameENST00000300651ENST00000360317MED1chr17

37575970

-GSDMBchr17

38062524

-
In-frameENST00000300651ENST00000360317MED1chr17

37575969

-GSDMBchr17

38062524

-
In-frameENST00000300651ENST00000360317MED1chr17

37575970

-GSDMBchr17

38063240

-
In-frameENST00000300651ENST00000394175MED1chr17

37575969

-GSDMBchr17

38062523

-
In-frameENST00000300651ENST00000394175MED1chr17

37575970

-GSDMBchr17

38062524

-
In-frameENST00000300651ENST00000394175MED1chr17

37575969

-GSDMBchr17

38062524

-
In-frameENST00000300651ENST00000394179MED1chr17

37575969

-GSDMBchr17

38062523

-
In-frameENST00000300651ENST00000394179MED1chr17

37575970

-GSDMBchr17

38062524

-
In-frameENST00000300651ENST00000394179MED1chr17

37575969

-GSDMBchr17

38062524

-
In-frameENST00000300651ENST00000418519MED1chr17

37575969

-GSDMBchr17

38062523

-
In-frameENST00000300651ENST00000418519MED1chr17

37575970

-GSDMBchr17

38062524

-
In-frameENST00000300651ENST00000418519MED1chr17

37575969

-GSDMBchr17

38062524

-
In-frameENST00000300651ENST00000520542MED1chr17

37575969

-GSDMBchr17

38062523

-
In-frameENST00000300651ENST00000520542MED1chr17

37575970

-GSDMBchr17

38062524

-
In-frameENST00000300651ENST00000520542MED1chr17

37575969

-GSDMBchr17

38062524

-
In-frameENST00000394287ENST00000309481MED1chr17

37575969

-GSDMBchr17

38062523

-
In-frameENST00000394287ENST00000309481MED1chr17

37575970

-GSDMBchr17

38062524

-
In-frameENST00000394287ENST00000309481MED1chr17

37575969

-GSDMBchr17

38062524

-
In-frameENST00000394287ENST00000360317MED1chr17

37575969

-GSDMBchr17

38062523

-
In-frameENST00000394287ENST00000360317MED1chr17

37575969

-GSDMBchr17

38063239

-
In-frameENST00000394287ENST00000360317MED1chr17

37575970

-GSDMBchr17

38062524

-
In-frameENST00000394287ENST00000360317MED1chr17

37575969

-GSDMBchr17

38062524

-
In-frameENST00000394287ENST00000360317MED1chr17

37575970

-GSDMBchr17

38063240

-
In-frameENST00000394287ENST00000394175MED1chr17

37575969

-GSDMBchr17

38062523

-
In-frameENST00000394287ENST00000394175MED1chr17

37575970

-GSDMBchr17

38062524

-
In-frameENST00000394287ENST00000394175MED1chr17

37575969

-GSDMBchr17

38062524

-
In-frameENST00000394287ENST00000394179MED1chr17

37575969

-GSDMBchr17

38062523

-
In-frameENST00000394287ENST00000394179MED1chr17

37575970

-GSDMBchr17

38062524

-
In-frameENST00000394287ENST00000394179MED1chr17

37575969

-GSDMBchr17

38062524

-
In-frameENST00000394287ENST00000418519MED1chr17

37575969

-GSDMBchr17

38062523

-
In-frameENST00000394287ENST00000418519MED1chr17

37575970

-GSDMBchr17

38062524

-
In-frameENST00000394287ENST00000418519MED1chr17

37575969

-GSDMBchr17

38062524

-
In-frameENST00000394287ENST00000520542MED1chr17

37575969

-GSDMBchr17

38062523

-
In-frameENST00000394287ENST00000520542MED1chr17

37575970

-GSDMBchr17

38062524

-
In-frameENST00000394287ENST00000520542MED1chr17

37575969

-GSDMBchr17

38062524

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000394287MED1chr1737575970-ENST00000360317GSDMBchr1738062524-224415032062026606
ENST00000394287MED1chr1737575970-ENST00000394175GSDMBchr1738062524-224415032062026606
ENST00000394287MED1chr1737575970-ENST00000309481GSDMBchr1738062524-224415032062026606
ENST00000394287MED1chr1737575970-ENST00000520542GSDMBchr1738062524-224215032062026606
ENST00000394287MED1chr1737575970-ENST00000418519GSDMBchr1738062524-224215032062026606
ENST00000394287MED1chr1737575970-ENST00000394179GSDMBchr1738062524-224215032062026606
ENST00000300651MED1chr1737575970-ENST00000360317GSDMBchr1738062524-226215212242044606
ENST00000300651MED1chr1737575970-ENST00000394175GSDMBchr1738062524-226215212242044606
ENST00000300651MED1chr1737575970-ENST00000309481GSDMBchr1738062524-226215212242044606
ENST00000300651MED1chr1737575970-ENST00000520542GSDMBchr1738062524-226015212242044606
ENST00000300651MED1chr1737575970-ENST00000418519GSDMBchr1738062524-226015212242044606
ENST00000300651MED1chr1737575970-ENST00000394179GSDMBchr1738062524-226015212242044606
ENST00000394287MED1chr1737575969-ENST00000360317GSDMBchr1738062524-224415032062026606
ENST00000394287MED1chr1737575969-ENST00000394175GSDMBchr1738062524-224415032062026606
ENST00000394287MED1chr1737575969-ENST00000309481GSDMBchr1738062524-224415032062026606
ENST00000394287MED1chr1737575969-ENST00000520542GSDMBchr1738062524-224215032062026606
ENST00000394287MED1chr1737575969-ENST00000418519GSDMBchr1738062524-224215032062026606
ENST00000394287MED1chr1737575969-ENST00000394179GSDMBchr1738062524-224215032062026606
ENST00000300651MED1chr1737575969-ENST00000360317GSDMBchr1738062524-226215212242044606
ENST00000300651MED1chr1737575969-ENST00000394175GSDMBchr1738062524-226215212242044606
ENST00000300651MED1chr1737575969-ENST00000309481GSDMBchr1738062524-226215212242044606
ENST00000300651MED1chr1737575969-ENST00000520542GSDMBchr1738062524-226015212242044606
ENST00000300651MED1chr1737575969-ENST00000418519GSDMBchr1738062524-226015212242044606
ENST00000300651MED1chr1737575969-ENST00000394179GSDMBchr1738062524-226015212242044606
ENST00000394287MED1chr1737575970-ENST00000360317GSDMBchr1738063240-227115032062053615
ENST00000300651MED1chr1737575970-ENST00000360317GSDMBchr1738063240-228915212242071615
ENST00000394287MED1chr1737575969-ENST00000360317GSDMBchr1738062523-224415032062026606
ENST00000394287MED1chr1737575969-ENST00000394175GSDMBchr1738062523-224415032062026606
ENST00000394287MED1chr1737575969-ENST00000309481GSDMBchr1738062523-224415032062026606
ENST00000394287MED1chr1737575969-ENST00000520542GSDMBchr1738062523-224215032062026606
ENST00000394287MED1chr1737575969-ENST00000418519GSDMBchr1738062523-224215032062026606
ENST00000394287MED1chr1737575969-ENST00000394179GSDMBchr1738062523-224215032062026606
ENST00000300651MED1chr1737575969-ENST00000360317GSDMBchr1738062523-226215212242044606
ENST00000300651MED1chr1737575969-ENST00000394175GSDMBchr1738062523-226215212242044606
ENST00000300651MED1chr1737575969-ENST00000309481GSDMBchr1738062523-226215212242044606
ENST00000300651MED1chr1737575969-ENST00000520542GSDMBchr1738062523-226015212242044606
ENST00000300651MED1chr1737575969-ENST00000418519GSDMBchr1738062523-226015212242044606
ENST00000300651MED1chr1737575969-ENST00000394179GSDMBchr1738062523-226015212242044606
ENST00000394287MED1chr1737575969-ENST00000360317GSDMBchr1738063239-227115032062053615
ENST00000300651MED1chr1737575969-ENST00000360317GSDMBchr1738063239-228915212242071615

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000394287ENST00000360317MED1chr1737575970-GSDMBchr1738062524-0.0020468150.9979532
ENST00000394287ENST00000394175MED1chr1737575970-GSDMBchr1738062524-0.0020468150.9979532
ENST00000394287ENST00000309481MED1chr1737575970-GSDMBchr1738062524-0.0020468150.9979532
ENST00000394287ENST00000520542MED1chr1737575970-GSDMBchr1738062524-0.0020970190.997903
ENST00000394287ENST00000418519MED1chr1737575970-GSDMBchr1738062524-0.0020970190.997903
ENST00000394287ENST00000394179MED1chr1737575970-GSDMBchr1738062524-0.0020970190.997903
ENST00000300651ENST00000360317MED1chr1737575970-GSDMBchr1738062524-0.0020320960.9979679
ENST00000300651ENST00000394175MED1chr1737575970-GSDMBchr1738062524-0.0020320960.9979679
ENST00000300651ENST00000309481MED1chr1737575970-GSDMBchr1738062524-0.0020320960.9979679
ENST00000300651ENST00000520542MED1chr1737575970-GSDMBchr1738062524-0.0020846830.9979153
ENST00000300651ENST00000418519MED1chr1737575970-GSDMBchr1738062524-0.0020846830.9979153
ENST00000300651ENST00000394179MED1chr1737575970-GSDMBchr1738062524-0.0020846830.9979153
ENST00000394287ENST00000360317MED1chr1737575969-GSDMBchr1738062524-0.0020468150.9979532
ENST00000394287ENST00000394175MED1chr1737575969-GSDMBchr1738062524-0.0020468150.9979532
ENST00000394287ENST00000309481MED1chr1737575969-GSDMBchr1738062524-0.0020468150.9979532
ENST00000394287ENST00000520542MED1chr1737575969-GSDMBchr1738062524-0.0020970190.997903
ENST00000394287ENST00000418519MED1chr1737575969-GSDMBchr1738062524-0.0020970190.997903
ENST00000394287ENST00000394179MED1chr1737575969-GSDMBchr1738062524-0.0020970190.997903
ENST00000300651ENST00000360317MED1chr1737575969-GSDMBchr1738062524-0.0020320960.9979679
ENST00000300651ENST00000394175MED1chr1737575969-GSDMBchr1738062524-0.0020320960.9979679
ENST00000300651ENST00000309481MED1chr1737575969-GSDMBchr1738062524-0.0020320960.9979679
ENST00000300651ENST00000520542MED1chr1737575969-GSDMBchr1738062524-0.0020846830.9979153
ENST00000300651ENST00000418519MED1chr1737575969-GSDMBchr1738062524-0.0020846830.9979153
ENST00000300651ENST00000394179MED1chr1737575969-GSDMBchr1738062524-0.0020846830.9979153
ENST00000394287ENST00000360317MED1chr1737575970-GSDMBchr1738063240-0.0028369180.997163
ENST00000300651ENST00000360317MED1chr1737575970-GSDMBchr1738063240-0.0028157570.9971842
ENST00000394287ENST00000360317MED1chr1737575969-GSDMBchr1738062523-0.0020468150.9979532
ENST00000394287ENST00000394175MED1chr1737575969-GSDMBchr1738062523-0.0020468150.9979532
ENST00000394287ENST00000309481MED1chr1737575969-GSDMBchr1738062523-0.0020468150.9979532
ENST00000394287ENST00000520542MED1chr1737575969-GSDMBchr1738062523-0.0020970190.997903
ENST00000394287ENST00000418519MED1chr1737575969-GSDMBchr1738062523-0.0020970190.997903
ENST00000394287ENST00000394179MED1chr1737575969-GSDMBchr1738062523-0.0020970190.997903
ENST00000300651ENST00000360317MED1chr1737575969-GSDMBchr1738062523-0.0020320960.9979679
ENST00000300651ENST00000394175MED1chr1737575969-GSDMBchr1738062523-0.0020320960.9979679
ENST00000300651ENST00000309481MED1chr1737575969-GSDMBchr1738062523-0.0020320960.9979679
ENST00000300651ENST00000520542MED1chr1737575969-GSDMBchr1738062523-0.0020846830.9979153
ENST00000300651ENST00000418519MED1chr1737575969-GSDMBchr1738062523-0.0020846830.9979153
ENST00000300651ENST00000394179MED1chr1737575969-GSDMBchr1738062523-0.0020846830.9979153
ENST00000394287ENST00000360317MED1chr1737575969-GSDMBchr1738063239-0.0028369180.997163
ENST00000300651ENST00000360317MED1chr1737575969-GSDMBchr1738063239-0.0028157570.9971842

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Fusion Genomic Features for MED1-GSDMB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MED1-GSDMB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:37575970/chr17:38062524)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MED1

Q15648

GSDMB

Q8TAX9

FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}.FUNCTION: [Gasdermin-B]: Precursor of a pore-forming protein that acts as a downstream mediator of granzyme-mediated cell death (PubMed:32299851). This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-B, N-terminal) binds to membranes and forms pores, triggering pyroptosis (PubMed:32299851). {ECO:0000269|PubMed:32299851}.; FUNCTION: [Gasdermin-B, N-terminal]: Pore-forming protein produced by cleavage by granzyme A (GZMA), which causes membrane permeabilization and pyroptosis in target cells of cytotoxic T and natural killer (NK) cells (PubMed:27281216, PubMed:32299851). Key downstream mediator of granzyme-mediated cell death: (1) granzyme A (GZMA), delivered to target cells from cytotoxic T- and NK-cells, (2) specifically cleaves Gasdermin-B to generate this form (PubMed:32299851). After cleavage, moves to the plasma membrane, homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis (PubMed:32299851). Binds to membrane inner leaflet lipids, such as phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate, and more weakly to phosphatidic acid (PubMed:28154144). Also binds sufatide, a component of the apical membrane of epithelial cells (PubMed:28154144). {ECO:0000269|PubMed:27281216, ECO:0000269|PubMed:28154144, ECO:0000269|PubMed:32299851}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

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* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGSDMBchr17:37575969chr17:38062523ENST00000309481510243_271229404.0Coiled coilOntology_term=ECO:0000255
TgeneGSDMBchr17:37575969chr17:38062523ENST00000360317510243_271242417.0Coiled coilOntology_term=ECO:0000255
TgeneGSDMBchr17:37575969chr17:38062523ENST0000039417538243_271220395.0Coiled coilOntology_term=ECO:0000255
TgeneGSDMBchr17:37575969chr17:38062523ENST00000394179510243_271237412.0Coiled coilOntology_term=ECO:0000255
TgeneGSDMBchr17:37575969chr17:38062523ENST00000418519611243_271242417.0Coiled coilOntology_term=ECO:0000255
TgeneGSDMBchr17:37575969chr17:38062523ENST00000520542510243_271233408.0Coiled coilOntology_term=ECO:0000255
TgeneGSDMBchr17:37575969chr17:38062524ENST00000309481510243_271229404.0Coiled coilOntology_term=ECO:0000255
TgeneGSDMBchr17:37575969chr17:38062524ENST00000360317510243_271242417.0Coiled coilOntology_term=ECO:0000255
TgeneGSDMBchr17:37575969chr17:38062524ENST0000039417538243_271220395.0Coiled coilOntology_term=ECO:0000255
TgeneGSDMBchr17:37575969chr17:38062524ENST00000394179510243_271237412.0Coiled coilOntology_term=ECO:0000255
TgeneGSDMBchr17:37575969chr17:38062524ENST00000418519611243_271242417.0Coiled coilOntology_term=ECO:0000255
TgeneGSDMBchr17:37575969chr17:38062524ENST00000520542510243_271233408.0Coiled coilOntology_term=ECO:0000255
TgeneGSDMBchr17:37575969chr17:38063239ENST00000309481410243_271220404.0Coiled coilOntology_term=ECO:0000255
TgeneGSDMBchr17:37575969chr17:38063239ENST00000360317410243_271233417.0Coiled coilOntology_term=ECO:0000255
TgeneGSDMBchr17:37575969chr17:38063239ENST0000039417508243_2710395.0Coiled coilOntology_term=ECO:0000255
TgeneGSDMBchr17:37575969chr17:38063239ENST00000394179010243_2710412.0Coiled coilOntology_term=ECO:0000255
TgeneGSDMBchr17:37575969chr17:38063239ENST00000418519511243_271233417.0Coiled coilOntology_term=ECO:0000255
TgeneGSDMBchr17:37575969chr17:38063239ENST00000520542010243_2710408.0Coiled coilOntology_term=ECO:0000255
TgeneGSDMBchr17:37575970chr17:38062524ENST00000309481510243_271229404.0Coiled coilOntology_term=ECO:0000255
TgeneGSDMBchr17:37575970chr17:38062524ENST00000360317510243_271242417.0Coiled coilOntology_term=ECO:0000255
TgeneGSDMBchr17:37575970chr17:38062524ENST0000039417538243_271220395.0Coiled coilOntology_term=ECO:0000255
TgeneGSDMBchr17:37575970chr17:38062524ENST00000394179510243_271237412.0Coiled coilOntology_term=ECO:0000255
TgeneGSDMBchr17:37575970chr17:38062524ENST00000418519611243_271242417.0Coiled coilOntology_term=ECO:0000255
TgeneGSDMBchr17:37575970chr17:38062524ENST00000520542510243_271233408.0Coiled coilOntology_term=ECO:0000255
TgeneGSDMBchr17:37575970chr17:38063240ENST00000309481410243_271220404.0Coiled coilOntology_term=ECO:0000255
TgeneGSDMBchr17:37575970chr17:38063240ENST00000360317410243_271233417.0Coiled coilOntology_term=ECO:0000255
TgeneGSDMBchr17:37575970chr17:38063240ENST0000039417508243_2710395.0Coiled coilOntology_term=ECO:0000255
TgeneGSDMBchr17:37575970chr17:38063240ENST00000394179010243_2710412.0Coiled coilOntology_term=ECO:0000255
TgeneGSDMBchr17:37575970chr17:38063240ENST00000418519511243_271233417.0Coiled coilOntology_term=ECO:0000255
TgeneGSDMBchr17:37575970chr17:38063240ENST00000520542010243_2710408.0Coiled coilOntology_term=ECO:0000255
TgeneGSDMBchr17:37575969chr17:38063239ENST00000394175081_2750395.0RegionTriggers pyroptosis
TgeneGSDMBchr17:37575969chr17:38063239ENST000003941790101_2750412.0RegionTriggers pyroptosis
TgeneGSDMBchr17:37575969chr17:38063239ENST000005205420101_2750408.0RegionTriggers pyroptosis
TgeneGSDMBchr17:37575970chr17:38063240ENST00000394175081_2750395.0RegionTriggers pyroptosis
TgeneGSDMBchr17:37575970chr17:38063240ENST000003941790101_2750412.0RegionTriggers pyroptosis
TgeneGSDMBchr17:37575970chr17:38063240ENST000005205420101_2750408.0RegionTriggers pyroptosis

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMED1chr17:37575969chr17:38062523ENST00000300651-14171078_14824321582.0Compositional biasNote=Ser-rich
HgeneMED1chr17:37575969chr17:38062523ENST00000300651-14171496_15294321582.0Compositional biasNote=Lys-rich
HgeneMED1chr17:37575969chr17:38062523ENST00000394287-14181078_1482432557.0Compositional biasNote=Ser-rich
HgeneMED1chr17:37575969chr17:38062523ENST00000394287-14181496_1529432557.0Compositional biasNote=Lys-rich
HgeneMED1chr17:37575969chr17:38062524ENST00000300651-14171078_14824321582.0Compositional biasNote=Ser-rich
HgeneMED1chr17:37575969chr17:38062524ENST00000300651-14171496_15294321582.0Compositional biasNote=Lys-rich
HgeneMED1chr17:37575969chr17:38062524ENST00000394287-14181078_1482432557.0Compositional biasNote=Ser-rich
HgeneMED1chr17:37575969chr17:38062524ENST00000394287-14181496_1529432557.0Compositional biasNote=Lys-rich
HgeneMED1chr17:37575969chr17:38063239ENST00000300651-14171078_14824321582.0Compositional biasNote=Ser-rich
HgeneMED1chr17:37575969chr17:38063239ENST00000300651-14171496_15294321582.0Compositional biasNote=Lys-rich
HgeneMED1chr17:37575969chr17:38063239ENST00000394287-14181078_1482432557.0Compositional biasNote=Ser-rich
HgeneMED1chr17:37575969chr17:38063239ENST00000394287-14181496_1529432557.0Compositional biasNote=Lys-rich
HgeneMED1chr17:37575970chr17:38062524ENST00000300651-14171078_14824321582.0Compositional biasNote=Ser-rich
HgeneMED1chr17:37575970chr17:38062524ENST00000300651-14171496_15294321582.0Compositional biasNote=Lys-rich
HgeneMED1chr17:37575970chr17:38062524ENST00000394287-14181078_1482432557.0Compositional biasNote=Ser-rich
HgeneMED1chr17:37575970chr17:38062524ENST00000394287-14181496_1529432557.0Compositional biasNote=Lys-rich
HgeneMED1chr17:37575970chr17:38063240ENST00000300651-14171078_14824321582.0Compositional biasNote=Ser-rich
HgeneMED1chr17:37575970chr17:38063240ENST00000300651-14171496_15294321582.0Compositional biasNote=Lys-rich
HgeneMED1chr17:37575970chr17:38063240ENST00000394287-14181078_1482432557.0Compositional biasNote=Ser-rich
HgeneMED1chr17:37575970chr17:38063240ENST00000394287-14181496_1529432557.0Compositional biasNote=Lys-rich
HgeneMED1chr17:37575969chr17:38062523ENST00000300651-1417604_6084321582.0MotifNote=LXXLL motif 1
HgeneMED1chr17:37575969chr17:38062523ENST00000300651-1417645_6494321582.0MotifNote=LXXLL motif 2
HgeneMED1chr17:37575969chr17:38062523ENST00000300651-1417875_9024321582.0MotifIntegrase domain-binding motif (IBM)
HgeneMED1chr17:37575969chr17:38062523ENST00000394287-1418604_608432557.0MotifNote=LXXLL motif 1
HgeneMED1chr17:37575969chr17:38062523ENST00000394287-1418645_649432557.0MotifNote=LXXLL motif 2
HgeneMED1chr17:37575969chr17:38062523ENST00000394287-1418875_902432557.0MotifIntegrase domain-binding motif (IBM)
HgeneMED1chr17:37575969chr17:38062524ENST00000300651-1417604_6084321582.0MotifNote=LXXLL motif 1
HgeneMED1chr17:37575969chr17:38062524ENST00000300651-1417645_6494321582.0MotifNote=LXXLL motif 2
HgeneMED1chr17:37575969chr17:38062524ENST00000300651-1417875_9024321582.0MotifIntegrase domain-binding motif (IBM)
HgeneMED1chr17:37575969chr17:38062524ENST00000394287-1418604_608432557.0MotifNote=LXXLL motif 1
HgeneMED1chr17:37575969chr17:38062524ENST00000394287-1418645_649432557.0MotifNote=LXXLL motif 2
HgeneMED1chr17:37575969chr17:38062524ENST00000394287-1418875_902432557.0MotifIntegrase domain-binding motif (IBM)
HgeneMED1chr17:37575969chr17:38063239ENST00000300651-1417604_6084321582.0MotifNote=LXXLL motif 1
HgeneMED1chr17:37575969chr17:38063239ENST00000300651-1417645_6494321582.0MotifNote=LXXLL motif 2
HgeneMED1chr17:37575969chr17:38063239ENST00000300651-1417875_9024321582.0MotifIntegrase domain-binding motif (IBM)
HgeneMED1chr17:37575969chr17:38063239ENST00000394287-1418604_608432557.0MotifNote=LXXLL motif 1
HgeneMED1chr17:37575969chr17:38063239ENST00000394287-1418645_649432557.0MotifNote=LXXLL motif 2
HgeneMED1chr17:37575969chr17:38063239ENST00000394287-1418875_902432557.0MotifIntegrase domain-binding motif (IBM)
HgeneMED1chr17:37575970chr17:38062524ENST00000300651-1417604_6084321582.0MotifNote=LXXLL motif 1
HgeneMED1chr17:37575970chr17:38062524ENST00000300651-1417645_6494321582.0MotifNote=LXXLL motif 2
HgeneMED1chr17:37575970chr17:38062524ENST00000300651-1417875_9024321582.0MotifIntegrase domain-binding motif (IBM)
HgeneMED1chr17:37575970chr17:38062524ENST00000394287-1418604_608432557.0MotifNote=LXXLL motif 1
HgeneMED1chr17:37575970chr17:38062524ENST00000394287-1418645_649432557.0MotifNote=LXXLL motif 2
HgeneMED1chr17:37575970chr17:38062524ENST00000394287-1418875_902432557.0MotifIntegrase domain-binding motif (IBM)
HgeneMED1chr17:37575970chr17:38063240ENST00000300651-1417604_6084321582.0MotifNote=LXXLL motif 1
HgeneMED1chr17:37575970chr17:38063240ENST00000300651-1417645_6494321582.0MotifNote=LXXLL motif 2
HgeneMED1chr17:37575970chr17:38063240ENST00000300651-1417875_9024321582.0MotifIntegrase domain-binding motif (IBM)
HgeneMED1chr17:37575970chr17:38063240ENST00000394287-1418604_608432557.0MotifNote=LXXLL motif 1
HgeneMED1chr17:37575970chr17:38063240ENST00000394287-1418645_649432557.0MotifNote=LXXLL motif 2
HgeneMED1chr17:37575970chr17:38063240ENST00000394287-1418875_902432557.0MotifIntegrase domain-binding motif (IBM)
TgeneGSDMBchr17:37575969chr17:38062523ENST000003094815101_275229404.0RegionTriggers pyroptosis
TgeneGSDMBchr17:37575969chr17:38062523ENST000003603175101_275242417.0RegionTriggers pyroptosis
TgeneGSDMBchr17:37575969chr17:38062523ENST00000394175381_275220395.0RegionTriggers pyroptosis
TgeneGSDMBchr17:37575969chr17:38062523ENST000003941795101_275237412.0RegionTriggers pyroptosis
TgeneGSDMBchr17:37575969chr17:38062523ENST000004185196111_275242417.0RegionTriggers pyroptosis
TgeneGSDMBchr17:37575969chr17:38062523ENST000005205425101_275233408.0RegionTriggers pyroptosis
TgeneGSDMBchr17:37575969chr17:38062524ENST000003094815101_275229404.0RegionTriggers pyroptosis
TgeneGSDMBchr17:37575969chr17:38062524ENST000003603175101_275242417.0RegionTriggers pyroptosis
TgeneGSDMBchr17:37575969chr17:38062524ENST00000394175381_275220395.0RegionTriggers pyroptosis
TgeneGSDMBchr17:37575969chr17:38062524ENST000003941795101_275237412.0RegionTriggers pyroptosis
TgeneGSDMBchr17:37575969chr17:38062524ENST000004185196111_275242417.0RegionTriggers pyroptosis
TgeneGSDMBchr17:37575969chr17:38062524ENST000005205425101_275233408.0RegionTriggers pyroptosis
TgeneGSDMBchr17:37575969chr17:38063239ENST000003094814101_275220404.0RegionTriggers pyroptosis
TgeneGSDMBchr17:37575969chr17:38063239ENST000003603174101_275233417.0RegionTriggers pyroptosis
TgeneGSDMBchr17:37575969chr17:38063239ENST000004185195111_275233417.0RegionTriggers pyroptosis
TgeneGSDMBchr17:37575970chr17:38062524ENST000003094815101_275229404.0RegionTriggers pyroptosis
TgeneGSDMBchr17:37575970chr17:38062524ENST000003603175101_275242417.0RegionTriggers pyroptosis
TgeneGSDMBchr17:37575970chr17:38062524ENST00000394175381_275220395.0RegionTriggers pyroptosis
TgeneGSDMBchr17:37575970chr17:38062524ENST000003941795101_275237412.0RegionTriggers pyroptosis
TgeneGSDMBchr17:37575970chr17:38062524ENST000004185196111_275242417.0RegionTriggers pyroptosis
TgeneGSDMBchr17:37575970chr17:38062524ENST000005205425101_275233408.0RegionTriggers pyroptosis
TgeneGSDMBchr17:37575970chr17:38063240ENST000003094814101_275220404.0RegionTriggers pyroptosis
TgeneGSDMBchr17:37575970chr17:38063240ENST000003603174101_275233417.0RegionTriggers pyroptosis
TgeneGSDMBchr17:37575970chr17:38063240ENST000004185195111_275233417.0RegionTriggers pyroptosis


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Fusion Gene Sequence for MED1-GSDMB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>52653_52653_1_MED1-GSDMB_MED1_chr17_37575969_ENST00000300651_GSDMB_chr17_38062523_ENST00000309481_length(transcript)=2262nt_BP=1521nt
ACGGTTTATCTCGCGAATTTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAG
ATTGATCCTTCCCGGGAAGAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAG
GGCTTATCCTTTTGTGGCGGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGA
TGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGA
AGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAG
CAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAG
ATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTC
CGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGG
ACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTA
ATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATG
TCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCAT
CAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCC
CTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAG
CATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGT
TTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCC
TCAACAAGGATGCTCCTCTTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTC
TTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTT
TGGGTTCGGAGGATTCCAGAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATG
TGCTAAACTCCCTCGCTAAGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGC
TACACATGGAGGACCCAGACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGG
ACTTCCTGGATGCCCTGCTAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACC
AGGTGAAATCTGTCATGGAGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTG
CGCTGTATGTTGTTGTCTCTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAA
GCCTCTGGGTTTTCCCTTTACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCA
ACCATTCTTTGATGTATCCCATTCGCTCCATGTTAACATCCAAAACCAGCCTGGATTTCATACATGGACTTCTGATTAAAAGTGGCAGGT

>52653_52653_1_MED1-GSDMB_MED1_chr17_37575969_ENST00000300651_GSDMB_chr17_38062523_ENST00000309481_length(amino acids)=606AA_BP=432
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL
GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI
APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED
MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF

--------------------------------------------------------------
>52653_52653_2_MED1-GSDMB_MED1_chr17_37575969_ENST00000300651_GSDMB_chr17_38062523_ENST00000360317_length(transcript)=2262nt_BP=1521nt
ACGGTTTATCTCGCGAATTTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAG
ATTGATCCTTCCCGGGAAGAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAG
GGCTTATCCTTTTGTGGCGGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGA
TGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGA
AGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAG
CAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAG
ATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTC
CGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGG
ACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTA
ATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATG
TCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCAT
CAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCC
CTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAG
CATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGT
TTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCC
TCAACAAGGATGCTCCTCTTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTC
TTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTT
TGGGTTCGGAGGATTCCAGAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATG
TGCTAAACTCCCTCGCTAAGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGC
TACACATGGAGGACCCAGACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGG
ACTTCCTGGATGCCCTGCTAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACC
AGGTGAAATCTGTCATGGAGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTG
CGCTGTATGTTGTTGTCTCTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAA
GCCTCTGGGTTTTCCCTTTACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCA
ACCATTCTTTGATGTATCCCATTCGCTCCATGTTAACATCCAAAACCAGCCTGGATTTCATACATGGACTTCTGATTAAAAGTGGCAGGT

>52653_52653_2_MED1-GSDMB_MED1_chr17_37575969_ENST00000300651_GSDMB_chr17_38062523_ENST00000360317_length(amino acids)=606AA_BP=432
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL
GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI
APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED
MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF

--------------------------------------------------------------
>52653_52653_3_MED1-GSDMB_MED1_chr17_37575969_ENST00000300651_GSDMB_chr17_38062523_ENST00000394175_length(transcript)=2262nt_BP=1521nt
ACGGTTTATCTCGCGAATTTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAG
ATTGATCCTTCCCGGGAAGAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAG
GGCTTATCCTTTTGTGGCGGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGA
TGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGA
AGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAG
CAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAG
ATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTC
CGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGG
ACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTA
ATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATG
TCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCAT
CAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCC
CTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAG
CATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGT
TTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCC
TCAACAAGGATGCTCCTCTTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTC
TTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTT
TGGGTTCGGAGGATTCCAGAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATG
TGCTAAACTCCCTCGCTAAGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGC
TACACATGGAGGACCCAGACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGG
ACTTCCTGGATGCCCTGCTAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACC
AGGTGAAATCTGTCATGGAGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTG
CGCTGTATGTTGTTGTCTCTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAA
GCCTCTGGGTTTTCCCTTTACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCA
ACCATTCTTTGATGTATCCCATTCGCTCCATGTTAACATCCAAAACCAGCCTGGATTTCATACATGGACTTCTGATTAAAAGTGGCAGGT

>52653_52653_3_MED1-GSDMB_MED1_chr17_37575969_ENST00000300651_GSDMB_chr17_38062523_ENST00000394175_length(amino acids)=606AA_BP=432
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL
GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI
APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED
MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF

--------------------------------------------------------------
>52653_52653_4_MED1-GSDMB_MED1_chr17_37575969_ENST00000300651_GSDMB_chr17_38062523_ENST00000394179_length(transcript)=2260nt_BP=1521nt
ACGGTTTATCTCGCGAATTTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAG
ATTGATCCTTCCCGGGAAGAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAG
GGCTTATCCTTTTGTGGCGGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGA
TGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGA
AGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAG
CAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAG
ATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTC
CGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGG
ACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTA
ATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATG
TCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCAT
CAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCC
CTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAG
CATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGT
TTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCC
TCAACAAGGATGCTCCTCTTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTC
TTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTT
TGGGTTCGGAGGATTCCAGAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATG
TGCTAAACTCCCTCGCTAAGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGC
TACACATGGAGGACCCAGACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGG
ACTTCCTGGATGCCCTGCTAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACC
AGGTGAAATCTGTCATGGAGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTG
CGCTGTATGTTGTTGTCTCTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAA
GCCTCTGGGTTTTCCCTTTACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCA
ACCATTCTTTGATGTATCCCATTCGCTCCATGTTAACATCCAAAACCAGCCTGGATTTCATACATGGACTTCTGATTAAAAGTGGCAGGT

>52653_52653_4_MED1-GSDMB_MED1_chr17_37575969_ENST00000300651_GSDMB_chr17_38062523_ENST00000394179_length(amino acids)=606AA_BP=432
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL
GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI
APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED
MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF

--------------------------------------------------------------
>52653_52653_5_MED1-GSDMB_MED1_chr17_37575969_ENST00000300651_GSDMB_chr17_38062523_ENST00000418519_length(transcript)=2260nt_BP=1521nt
ACGGTTTATCTCGCGAATTTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAG
ATTGATCCTTCCCGGGAAGAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAG
GGCTTATCCTTTTGTGGCGGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGA
TGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGA
AGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAG
CAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAG
ATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTC
CGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGG
ACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTA
ATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATG
TCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCAT
CAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCC
CTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAG
CATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGT
TTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCC
TCAACAAGGATGCTCCTCTTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTC
TTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTT
TGGGTTCGGAGGATTCCAGAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATG
TGCTAAACTCCCTCGCTAAGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGC
TACACATGGAGGACCCAGACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGG
ACTTCCTGGATGCCCTGCTAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACC
AGGTGAAATCTGTCATGGAGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTG
CGCTGTATGTTGTTGTCTCTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAA
GCCTCTGGGTTTTCCCTTTACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCA
ACCATTCTTTGATGTATCCCATTCGCTCCATGTTAACATCCAAAACCAGCCTGGATTTCATACATGGACTTCTGATTAAAAGTGGCAGGT

>52653_52653_5_MED1-GSDMB_MED1_chr17_37575969_ENST00000300651_GSDMB_chr17_38062523_ENST00000418519_length(amino acids)=606AA_BP=432
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL
GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI
APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED
MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF

--------------------------------------------------------------
>52653_52653_6_MED1-GSDMB_MED1_chr17_37575969_ENST00000300651_GSDMB_chr17_38062523_ENST00000520542_length(transcript)=2260nt_BP=1521nt
ACGGTTTATCTCGCGAATTTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAG
ATTGATCCTTCCCGGGAAGAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAG
GGCTTATCCTTTTGTGGCGGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGA
TGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGA
AGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAG
CAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAG
ATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTC
CGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGG
ACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTA
ATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATG
TCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCAT
CAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCC
CTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAG
CATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGT
TTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCC
TCAACAAGGATGCTCCTCTTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTC
TTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTT
TGGGTTCGGAGGATTCCAGAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATG
TGCTAAACTCCCTCGCTAAGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGC
TACACATGGAGGACCCAGACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGG
ACTTCCTGGATGCCCTGCTAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACC
AGGTGAAATCTGTCATGGAGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTG
CGCTGTATGTTGTTGTCTCTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAA
GCCTCTGGGTTTTCCCTTTACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCA
ACCATTCTTTGATGTATCCCATTCGCTCCATGTTAACATCCAAAACCAGCCTGGATTTCATACATGGACTTCTGATTAAAAGTGGCAGGT

>52653_52653_6_MED1-GSDMB_MED1_chr17_37575969_ENST00000300651_GSDMB_chr17_38062523_ENST00000520542_length(amino acids)=606AA_BP=432
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL
GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI
APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED
MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF

--------------------------------------------------------------
>52653_52653_7_MED1-GSDMB_MED1_chr17_37575969_ENST00000300651_GSDMB_chr17_38062524_ENST00000309481_length(transcript)=2262nt_BP=1521nt
ACGGTTTATCTCGCGAATTTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAG
ATTGATCCTTCCCGGGAAGAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAG
GGCTTATCCTTTTGTGGCGGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGA
TGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGA
AGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAG
CAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAG
ATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTC
CGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGG
ACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTA
ATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATG
TCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCAT
CAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCC
CTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAG
CATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGT
TTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCC
TCAACAAGGATGCTCCTCTTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTC
TTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTT
TGGGTTCGGAGGATTCCAGAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATG
TGCTAAACTCCCTCGCTAAGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGC
TACACATGGAGGACCCAGACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGG
ACTTCCTGGATGCCCTGCTAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACC
AGGTGAAATCTGTCATGGAGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTG
CGCTGTATGTTGTTGTCTCTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAA
GCCTCTGGGTTTTCCCTTTACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCA
ACCATTCTTTGATGTATCCCATTCGCTCCATGTTAACATCCAAAACCAGCCTGGATTTCATACATGGACTTCTGATTAAAAGTGGCAGGT

>52653_52653_7_MED1-GSDMB_MED1_chr17_37575969_ENST00000300651_GSDMB_chr17_38062524_ENST00000309481_length(amino acids)=606AA_BP=432
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL
GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI
APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED
MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF

--------------------------------------------------------------
>52653_52653_8_MED1-GSDMB_MED1_chr17_37575969_ENST00000300651_GSDMB_chr17_38062524_ENST00000360317_length(transcript)=2262nt_BP=1521nt
ACGGTTTATCTCGCGAATTTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAG
ATTGATCCTTCCCGGGAAGAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAG
GGCTTATCCTTTTGTGGCGGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGA
TGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGA
AGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAG
CAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAG
ATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTC
CGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGG
ACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTA
ATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATG
TCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCAT
CAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCC
CTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAG
CATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGT
TTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCC
TCAACAAGGATGCTCCTCTTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTC
TTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTT
TGGGTTCGGAGGATTCCAGAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATG
TGCTAAACTCCCTCGCTAAGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGC
TACACATGGAGGACCCAGACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGG
ACTTCCTGGATGCCCTGCTAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACC
AGGTGAAATCTGTCATGGAGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTG
CGCTGTATGTTGTTGTCTCTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAA
GCCTCTGGGTTTTCCCTTTACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCA
ACCATTCTTTGATGTATCCCATTCGCTCCATGTTAACATCCAAAACCAGCCTGGATTTCATACATGGACTTCTGATTAAAAGTGGCAGGT

>52653_52653_8_MED1-GSDMB_MED1_chr17_37575969_ENST00000300651_GSDMB_chr17_38062524_ENST00000360317_length(amino acids)=606AA_BP=432
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL
GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI
APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED
MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF

--------------------------------------------------------------
>52653_52653_9_MED1-GSDMB_MED1_chr17_37575969_ENST00000300651_GSDMB_chr17_38062524_ENST00000394175_length(transcript)=2262nt_BP=1521nt
ACGGTTTATCTCGCGAATTTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAG
ATTGATCCTTCCCGGGAAGAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAG
GGCTTATCCTTTTGTGGCGGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGA
TGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGA
AGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAG
CAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAG
ATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTC
CGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGG
ACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTA
ATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATG
TCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCAT
CAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCC
CTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAG
CATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGT
TTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCC
TCAACAAGGATGCTCCTCTTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTC
TTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTT
TGGGTTCGGAGGATTCCAGAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATG
TGCTAAACTCCCTCGCTAAGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGC
TACACATGGAGGACCCAGACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGG
ACTTCCTGGATGCCCTGCTAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACC
AGGTGAAATCTGTCATGGAGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTG
CGCTGTATGTTGTTGTCTCTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAA
GCCTCTGGGTTTTCCCTTTACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCA
ACCATTCTTTGATGTATCCCATTCGCTCCATGTTAACATCCAAAACCAGCCTGGATTTCATACATGGACTTCTGATTAAAAGTGGCAGGT

>52653_52653_9_MED1-GSDMB_MED1_chr17_37575969_ENST00000300651_GSDMB_chr17_38062524_ENST00000394175_length(amino acids)=606AA_BP=432
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL
GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI
APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED
MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF

--------------------------------------------------------------
>52653_52653_10_MED1-GSDMB_MED1_chr17_37575969_ENST00000300651_GSDMB_chr17_38062524_ENST00000394179_length(transcript)=2260nt_BP=1521nt
ACGGTTTATCTCGCGAATTTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAG
ATTGATCCTTCCCGGGAAGAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAG
GGCTTATCCTTTTGTGGCGGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGA
TGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGA
AGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAG
CAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAG
ATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTC
CGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGG
ACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTA
ATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATG
TCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCAT
CAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCC
CTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAG
CATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGT
TTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCC
TCAACAAGGATGCTCCTCTTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTC
TTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTT
TGGGTTCGGAGGATTCCAGAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATG
TGCTAAACTCCCTCGCTAAGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGC
TACACATGGAGGACCCAGACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGG
ACTTCCTGGATGCCCTGCTAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACC
AGGTGAAATCTGTCATGGAGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTG
CGCTGTATGTTGTTGTCTCTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAA
GCCTCTGGGTTTTCCCTTTACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCA
ACCATTCTTTGATGTATCCCATTCGCTCCATGTTAACATCCAAAACCAGCCTGGATTTCATACATGGACTTCTGATTAAAAGTGGCAGGT

>52653_52653_10_MED1-GSDMB_MED1_chr17_37575969_ENST00000300651_GSDMB_chr17_38062524_ENST00000394179_length(amino acids)=606AA_BP=432
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL
GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI
APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED
MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF

--------------------------------------------------------------
>52653_52653_11_MED1-GSDMB_MED1_chr17_37575969_ENST00000300651_GSDMB_chr17_38062524_ENST00000418519_length(transcript)=2260nt_BP=1521nt
ACGGTTTATCTCGCGAATTTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAG
ATTGATCCTTCCCGGGAAGAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAG
GGCTTATCCTTTTGTGGCGGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGA
TGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGA
AGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAG
CAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAG
ATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTC
CGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGG
ACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTA
ATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATG
TCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCAT
CAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCC
CTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAG
CATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGT
TTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCC
TCAACAAGGATGCTCCTCTTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTC
TTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTT
TGGGTTCGGAGGATTCCAGAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATG
TGCTAAACTCCCTCGCTAAGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGC
TACACATGGAGGACCCAGACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGG
ACTTCCTGGATGCCCTGCTAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACC
AGGTGAAATCTGTCATGGAGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTG
CGCTGTATGTTGTTGTCTCTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAA
GCCTCTGGGTTTTCCCTTTACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCA
ACCATTCTTTGATGTATCCCATTCGCTCCATGTTAACATCCAAAACCAGCCTGGATTTCATACATGGACTTCTGATTAAAAGTGGCAGGT

>52653_52653_11_MED1-GSDMB_MED1_chr17_37575969_ENST00000300651_GSDMB_chr17_38062524_ENST00000418519_length(amino acids)=606AA_BP=432
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL
GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI
APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED
MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF

--------------------------------------------------------------
>52653_52653_12_MED1-GSDMB_MED1_chr17_37575969_ENST00000300651_GSDMB_chr17_38062524_ENST00000520542_length(transcript)=2260nt_BP=1521nt
ACGGTTTATCTCGCGAATTTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAG
ATTGATCCTTCCCGGGAAGAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAG
GGCTTATCCTTTTGTGGCGGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGA
TGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGA
AGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAG
CAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAG
ATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTC
CGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGG
ACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTA
ATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATG
TCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCAT
CAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCC
CTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAG
CATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGT
TTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCC
TCAACAAGGATGCTCCTCTTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTC
TTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTT
TGGGTTCGGAGGATTCCAGAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATG
TGCTAAACTCCCTCGCTAAGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGC
TACACATGGAGGACCCAGACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGG
ACTTCCTGGATGCCCTGCTAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACC
AGGTGAAATCTGTCATGGAGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTG
CGCTGTATGTTGTTGTCTCTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAA
GCCTCTGGGTTTTCCCTTTACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCA
ACCATTCTTTGATGTATCCCATTCGCTCCATGTTAACATCCAAAACCAGCCTGGATTTCATACATGGACTTCTGATTAAAAGTGGCAGGT

>52653_52653_12_MED1-GSDMB_MED1_chr17_37575969_ENST00000300651_GSDMB_chr17_38062524_ENST00000520542_length(amino acids)=606AA_BP=432
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL
GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI
APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED
MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF

--------------------------------------------------------------
>52653_52653_13_MED1-GSDMB_MED1_chr17_37575969_ENST00000300651_GSDMB_chr17_38063239_ENST00000360317_length(transcript)=2289nt_BP=1521nt
ACGGTTTATCTCGCGAATTTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAG
ATTGATCCTTCCCGGGAAGAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAG
GGCTTATCCTTTTGTGGCGGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGA
TGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGA
AGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAG
CAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAG
ATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTC
CGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGG
ACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTA
ATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATG
TCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCAT
CAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCC
CTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAG
CATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGT
TTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCC
TCAACAAGGATGCTCCTCTTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTC
TTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGAGAAGGATG
GTGCTTCATCCTGTTTAGGAAAGTCTTTGGGTTCGGAGGATTCCAGAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGG
ACCTGACAGAGGAGAAGAGAAAAGATGTGCTAAACTCCCTCGCTAAGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAG
TATCTGAGGTCCTGATTTCCGGGGAGCTACACATGGAGGACCCAGACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGG
TAGAAGCGCGTGCAAAAGCCATTCTGGACTTCCTGGATGCCCTGCTAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGA
AGGGGACCCTTCCTCTGTTGAAGGACCAGGTGAAATCTGTCATGGAGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACT
ATGACCCTGAGGCACGAATTCTCTGTGCGCTGTATGTTGTTGTCTCTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCT
AACTACAAAAGCCCTTTCTCCCCACAAGCCTCTGGGTTTTCCCTTTACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCA
GTGGGACCTCTTTAAAACAAGCAGCCAACCATTCTTTGATGTATCCCATTCGCTCCATGTTAACATCCAAAACCAGCCTGGATTTCATAC

>52653_52653_13_MED1-GSDMB_MED1_chr17_37575969_ENST00000300651_GSDMB_chr17_38063239_ENST00000360317_length(amino acids)=615AA_BP=432
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL
GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI
APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEEKDGASSCLGKSLGSEDS
RNMKEKLEDMESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDAL

--------------------------------------------------------------
>52653_52653_14_MED1-GSDMB_MED1_chr17_37575969_ENST00000394287_GSDMB_chr17_38062523_ENST00000309481_length(transcript)=2244nt_BP=1503nt
TTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAGATTGATCCTTCCCGGGAA
GAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAGGGCTTATCCTTTTGTGGC
GGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAAC
GGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTT
CTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGG
AGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAG
TGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGC
TAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTA
AAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATA
AGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTAC
TGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAA
CATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCA
CCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGC
AGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACC
CTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCCTCAACAAGGATGCTCCTC
TTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTCTTATCCTAAATCTGATCA
GACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTTTGGGTTCGGAGGATTCCA
GAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATGTGCTAAACTCCCTCGCTA
AGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGCTACACATGGAGGACCCAG
ACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGGACTTCCTGGATGCCCTGC
TAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACCAGGTGAAATCTGTCATGG
AGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTGCGCTGTATGTTGTTGTCT
CTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAAGCCTCTGGGTTTTCCCTT
TACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCAACCATTCTTTGATGTATC

>52653_52653_14_MED1-GSDMB_MED1_chr17_37575969_ENST00000394287_GSDMB_chr17_38062523_ENST00000309481_length(amino acids)=606AA_BP=432
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL
GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI
APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED
MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF

--------------------------------------------------------------
>52653_52653_15_MED1-GSDMB_MED1_chr17_37575969_ENST00000394287_GSDMB_chr17_38062523_ENST00000360317_length(transcript)=2244nt_BP=1503nt
TTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAGATTGATCCTTCCCGGGAA
GAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAGGGCTTATCCTTTTGTGGC
GGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAAC
GGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTT
CTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGG
AGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAG
TGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGC
TAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTA
AAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATA
AGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTAC
TGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAA
CATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCA
CCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGC
AGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACC
CTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCCTCAACAAGGATGCTCCTC
TTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTCTTATCCTAAATCTGATCA
GACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTTTGGGTTCGGAGGATTCCA
GAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATGTGCTAAACTCCCTCGCTA
AGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGCTACACATGGAGGACCCAG
ACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGGACTTCCTGGATGCCCTGC
TAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACCAGGTGAAATCTGTCATGG
AGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTGCGCTGTATGTTGTTGTCT
CTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAAGCCTCTGGGTTTTCCCTT
TACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCAACCATTCTTTGATGTATC

>52653_52653_15_MED1-GSDMB_MED1_chr17_37575969_ENST00000394287_GSDMB_chr17_38062523_ENST00000360317_length(amino acids)=606AA_BP=432
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL
GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI
APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED
MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF

--------------------------------------------------------------
>52653_52653_16_MED1-GSDMB_MED1_chr17_37575969_ENST00000394287_GSDMB_chr17_38062523_ENST00000394175_length(transcript)=2244nt_BP=1503nt
TTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAGATTGATCCTTCCCGGGAA
GAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAGGGCTTATCCTTTTGTGGC
GGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAAC
GGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTT
CTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGG
AGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAG
TGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGC
TAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTA
AAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATA
AGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTAC
TGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAA
CATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCA
CCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGC
AGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACC
CTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCCTCAACAAGGATGCTCCTC
TTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTCTTATCCTAAATCTGATCA
GACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTTTGGGTTCGGAGGATTCCA
GAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATGTGCTAAACTCCCTCGCTA
AGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGCTACACATGGAGGACCCAG
ACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGGACTTCCTGGATGCCCTGC
TAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACCAGGTGAAATCTGTCATGG
AGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTGCGCTGTATGTTGTTGTCT
CTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAAGCCTCTGGGTTTTCCCTT
TACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCAACCATTCTTTGATGTATC

>52653_52653_16_MED1-GSDMB_MED1_chr17_37575969_ENST00000394287_GSDMB_chr17_38062523_ENST00000394175_length(amino acids)=606AA_BP=432
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL
GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI
APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED
MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF

--------------------------------------------------------------
>52653_52653_17_MED1-GSDMB_MED1_chr17_37575969_ENST00000394287_GSDMB_chr17_38062523_ENST00000394179_length(transcript)=2242nt_BP=1503nt
TTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAGATTGATCCTTCCCGGGAA
GAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAGGGCTTATCCTTTTGTGGC
GGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAAC
GGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTT
CTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGG
AGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAG
TGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGC
TAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTA
AAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATA
AGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTAC
TGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAA
CATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCA
CCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGC
AGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACC
CTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCCTCAACAAGGATGCTCCTC
TTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTCTTATCCTAAATCTGATCA
GACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTTTGGGTTCGGAGGATTCCA
GAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATGTGCTAAACTCCCTCGCTA
AGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGCTACACATGGAGGACCCAG
ACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGGACTTCCTGGATGCCCTGC
TAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACCAGGTGAAATCTGTCATGG
AGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTGCGCTGTATGTTGTTGTCT
CTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAAGCCTCTGGGTTTTCCCTT
TACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCAACCATTCTTTGATGTATC

>52653_52653_17_MED1-GSDMB_MED1_chr17_37575969_ENST00000394287_GSDMB_chr17_38062523_ENST00000394179_length(amino acids)=606AA_BP=432
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL
GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI
APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED
MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF

--------------------------------------------------------------
>52653_52653_18_MED1-GSDMB_MED1_chr17_37575969_ENST00000394287_GSDMB_chr17_38062523_ENST00000418519_length(transcript)=2242nt_BP=1503nt
TTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAGATTGATCCTTCCCGGGAA
GAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAGGGCTTATCCTTTTGTGGC
GGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAAC
GGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTT
CTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGG
AGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAG
TGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGC
TAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTA
AAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATA
AGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTAC
TGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAA
CATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCA
CCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGC
AGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACC
CTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCCTCAACAAGGATGCTCCTC
TTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTCTTATCCTAAATCTGATCA
GACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTTTGGGTTCGGAGGATTCCA
GAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATGTGCTAAACTCCCTCGCTA
AGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGCTACACATGGAGGACCCAG
ACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGGACTTCCTGGATGCCCTGC
TAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACCAGGTGAAATCTGTCATGG
AGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTGCGCTGTATGTTGTTGTCT
CTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAAGCCTCTGGGTTTTCCCTT
TACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCAACCATTCTTTGATGTATC

>52653_52653_18_MED1-GSDMB_MED1_chr17_37575969_ENST00000394287_GSDMB_chr17_38062523_ENST00000418519_length(amino acids)=606AA_BP=432
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL
GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI
APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED
MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF

--------------------------------------------------------------
>52653_52653_19_MED1-GSDMB_MED1_chr17_37575969_ENST00000394287_GSDMB_chr17_38062523_ENST00000520542_length(transcript)=2242nt_BP=1503nt
TTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAGATTGATCCTTCCCGGGAA
GAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAGGGCTTATCCTTTTGTGGC
GGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAAC
GGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTT
CTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGG
AGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAG
TGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGC
TAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTA
AAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATA
AGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTAC
TGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAA
CATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCA
CCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGC
AGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACC
CTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCCTCAACAAGGATGCTCCTC
TTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTCTTATCCTAAATCTGATCA
GACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTTTGGGTTCGGAGGATTCCA
GAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATGTGCTAAACTCCCTCGCTA
AGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGCTACACATGGAGGACCCAG
ACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGGACTTCCTGGATGCCCTGC
TAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACCAGGTGAAATCTGTCATGG
AGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTGCGCTGTATGTTGTTGTCT
CTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAAGCCTCTGGGTTTTCCCTT
TACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCAACCATTCTTTGATGTATC

>52653_52653_19_MED1-GSDMB_MED1_chr17_37575969_ENST00000394287_GSDMB_chr17_38062523_ENST00000520542_length(amino acids)=606AA_BP=432
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL
GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI
APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED
MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF

--------------------------------------------------------------
>52653_52653_20_MED1-GSDMB_MED1_chr17_37575969_ENST00000394287_GSDMB_chr17_38062524_ENST00000309481_length(transcript)=2244nt_BP=1503nt
TTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAGATTGATCCTTCCCGGGAA
GAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAGGGCTTATCCTTTTGTGGC
GGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAAC
GGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTT
CTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGG
AGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAG
TGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGC
TAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTA
AAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATA
AGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTAC
TGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAA
CATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCA
CCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGC
AGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACC
CTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCCTCAACAAGGATGCTCCTC
TTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTCTTATCCTAAATCTGATCA
GACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTTTGGGTTCGGAGGATTCCA
GAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATGTGCTAAACTCCCTCGCTA
AGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGCTACACATGGAGGACCCAG
ACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGGACTTCCTGGATGCCCTGC
TAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACCAGGTGAAATCTGTCATGG
AGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTGCGCTGTATGTTGTTGTCT
CTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAAGCCTCTGGGTTTTCCCTT
TACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCAACCATTCTTTGATGTATC

>52653_52653_20_MED1-GSDMB_MED1_chr17_37575969_ENST00000394287_GSDMB_chr17_38062524_ENST00000309481_length(amino acids)=606AA_BP=432
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL
GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI
APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED
MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF

--------------------------------------------------------------
>52653_52653_21_MED1-GSDMB_MED1_chr17_37575969_ENST00000394287_GSDMB_chr17_38062524_ENST00000360317_length(transcript)=2244nt_BP=1503nt
TTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAGATTGATCCTTCCCGGGAA
GAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAGGGCTTATCCTTTTGTGGC
GGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAAC
GGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTT
CTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGG
AGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAG
TGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGC
TAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTA
AAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATA
AGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTAC
TGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAA
CATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCA
CCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGC
AGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACC
CTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCCTCAACAAGGATGCTCCTC
TTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTCTTATCCTAAATCTGATCA
GACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTTTGGGTTCGGAGGATTCCA
GAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATGTGCTAAACTCCCTCGCTA
AGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGCTACACATGGAGGACCCAG
ACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGGACTTCCTGGATGCCCTGC
TAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACCAGGTGAAATCTGTCATGG
AGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTGCGCTGTATGTTGTTGTCT
CTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAAGCCTCTGGGTTTTCCCTT
TACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCAACCATTCTTTGATGTATC

>52653_52653_21_MED1-GSDMB_MED1_chr17_37575969_ENST00000394287_GSDMB_chr17_38062524_ENST00000360317_length(amino acids)=606AA_BP=432
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL
GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI
APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED
MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF

--------------------------------------------------------------
>52653_52653_22_MED1-GSDMB_MED1_chr17_37575969_ENST00000394287_GSDMB_chr17_38062524_ENST00000394175_length(transcript)=2244nt_BP=1503nt
TTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAGATTGATCCTTCCCGGGAA
GAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAGGGCTTATCCTTTTGTGGC
GGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAAC
GGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTT
CTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGG
AGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAG
TGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGC
TAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTA
AAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATA
AGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTAC
TGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAA
CATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCA
CCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGC
AGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACC
CTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCCTCAACAAGGATGCTCCTC
TTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTCTTATCCTAAATCTGATCA
GACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTTTGGGTTCGGAGGATTCCA
GAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATGTGCTAAACTCCCTCGCTA
AGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGCTACACATGGAGGACCCAG
ACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGGACTTCCTGGATGCCCTGC
TAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACCAGGTGAAATCTGTCATGG
AGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTGCGCTGTATGTTGTTGTCT
CTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAAGCCTCTGGGTTTTCCCTT
TACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCAACCATTCTTTGATGTATC

>52653_52653_22_MED1-GSDMB_MED1_chr17_37575969_ENST00000394287_GSDMB_chr17_38062524_ENST00000394175_length(amino acids)=606AA_BP=432
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL
GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI
APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED
MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF

--------------------------------------------------------------
>52653_52653_23_MED1-GSDMB_MED1_chr17_37575969_ENST00000394287_GSDMB_chr17_38062524_ENST00000394179_length(transcript)=2242nt_BP=1503nt
TTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAGATTGATCCTTCCCGGGAA
GAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAGGGCTTATCCTTTTGTGGC
GGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAAC
GGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTT
CTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGG
AGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAG
TGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGC
TAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTA
AAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATA
AGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTAC
TGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAA
CATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCA
CCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGC
AGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACC
CTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCCTCAACAAGGATGCTCCTC
TTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTCTTATCCTAAATCTGATCA
GACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTTTGGGTTCGGAGGATTCCA
GAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATGTGCTAAACTCCCTCGCTA
AGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGCTACACATGGAGGACCCAG
ACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGGACTTCCTGGATGCCCTGC
TAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACCAGGTGAAATCTGTCATGG
AGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTGCGCTGTATGTTGTTGTCT
CTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAAGCCTCTGGGTTTTCCCTT
TACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCAACCATTCTTTGATGTATC

>52653_52653_23_MED1-GSDMB_MED1_chr17_37575969_ENST00000394287_GSDMB_chr17_38062524_ENST00000394179_length(amino acids)=606AA_BP=432
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL
GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI
APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED
MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF

--------------------------------------------------------------
>52653_52653_24_MED1-GSDMB_MED1_chr17_37575969_ENST00000394287_GSDMB_chr17_38062524_ENST00000418519_length(transcript)=2242nt_BP=1503nt
TTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAGATTGATCCTTCCCGGGAA
GAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAGGGCTTATCCTTTTGTGGC
GGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAAC
GGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTT
CTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGG
AGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAG
TGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGC
TAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTA
AAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATA
AGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTAC
TGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAA
CATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCA
CCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGC
AGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACC
CTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCCTCAACAAGGATGCTCCTC
TTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTCTTATCCTAAATCTGATCA
GACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTTTGGGTTCGGAGGATTCCA
GAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATGTGCTAAACTCCCTCGCTA
AGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGCTACACATGGAGGACCCAG
ACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGGACTTCCTGGATGCCCTGC
TAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACCAGGTGAAATCTGTCATGG
AGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTGCGCTGTATGTTGTTGTCT
CTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAAGCCTCTGGGTTTTCCCTT
TACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCAACCATTCTTTGATGTATC

>52653_52653_24_MED1-GSDMB_MED1_chr17_37575969_ENST00000394287_GSDMB_chr17_38062524_ENST00000418519_length(amino acids)=606AA_BP=432
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL
GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI
APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED
MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF

--------------------------------------------------------------
>52653_52653_25_MED1-GSDMB_MED1_chr17_37575969_ENST00000394287_GSDMB_chr17_38062524_ENST00000520542_length(transcript)=2242nt_BP=1503nt
TTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAGATTGATCCTTCCCGGGAA
GAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAGGGCTTATCCTTTTGTGGC
GGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAAC
GGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTT
CTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGG
AGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAG
TGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGC
TAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTA
AAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATA
AGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTAC
TGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAA
CATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCA
CCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGC
AGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACC
CTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCCTCAACAAGGATGCTCCTC
TTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTCTTATCCTAAATCTGATCA
GACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTTTGGGTTCGGAGGATTCCA
GAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATGTGCTAAACTCCCTCGCTA
AGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGCTACACATGGAGGACCCAG
ACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGGACTTCCTGGATGCCCTGC
TAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACCAGGTGAAATCTGTCATGG
AGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTGCGCTGTATGTTGTTGTCT
CTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAAGCCTCTGGGTTTTCCCTT
TACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCAACCATTCTTTGATGTATC

>52653_52653_25_MED1-GSDMB_MED1_chr17_37575969_ENST00000394287_GSDMB_chr17_38062524_ENST00000520542_length(amino acids)=606AA_BP=432
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL
GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI
APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED
MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF

--------------------------------------------------------------
>52653_52653_26_MED1-GSDMB_MED1_chr17_37575969_ENST00000394287_GSDMB_chr17_38063239_ENST00000360317_length(transcript)=2271nt_BP=1503nt
TTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAGATTGATCCTTCCCGGGAA
GAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAGGGCTTATCCTTTTGTGGC
GGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAAC
GGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTT
CTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGG
AGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAG
TGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGC
TAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTA
AAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATA
AGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTAC
TGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAA
CATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCA
CCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGC
AGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACC
CTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCCTCAACAAGGATGCTCCTC
TTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTCTTATCCTAAATCTGATCA
GACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGAGAAGGATGGTGCTTCATCCTGTTTAG
GAAAGTCTTTGGGTTCGGAGGATTCCAGAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGA
GAAAAGATGTGCTAAACTCCCTCGCTAAGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTT
CCGGGGAGCTACACATGGAGGACCCAGACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAG
CCATTCTGGACTTCCTGGATGCCCTGCTAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGT
TGAAGGACCAGGTGAAATCTGTCATGGAGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAA
TTCTCTGTGCGCTGTATGTTGTTGTCTCTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTC
TCCCCACAAGCCTCTGGGTTTTCCCTTTACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAAC
AAGCAGCCAACCATTCTTTGATGTATCCCATTCGCTCCATGTTAACATCCAAAACCAGCCTGGATTTCATACATGGACTTCTGATTAAAA

>52653_52653_26_MED1-GSDMB_MED1_chr17_37575969_ENST00000394287_GSDMB_chr17_38063239_ENST00000360317_length(amino acids)=615AA_BP=432
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL
GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI
APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEEKDGASSCLGKSLGSEDS
RNMKEKLEDMESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDAL

--------------------------------------------------------------
>52653_52653_27_MED1-GSDMB_MED1_chr17_37575970_ENST00000300651_GSDMB_chr17_38062524_ENST00000309481_length(transcript)=2262nt_BP=1521nt
ACGGTTTATCTCGCGAATTTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAG
ATTGATCCTTCCCGGGAAGAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAG
GGCTTATCCTTTTGTGGCGGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGA
TGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGA
AGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAG
CAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAG
ATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTC
CGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGG
ACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTA
ATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATG
TCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCAT
CAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCC
CTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAG
CATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGT
TTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCC
TCAACAAGGATGCTCCTCTTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTC
TTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTT
TGGGTTCGGAGGATTCCAGAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATG
TGCTAAACTCCCTCGCTAAGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGC
TACACATGGAGGACCCAGACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGG
ACTTCCTGGATGCCCTGCTAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACC
AGGTGAAATCTGTCATGGAGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTG
CGCTGTATGTTGTTGTCTCTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAA
GCCTCTGGGTTTTCCCTTTACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCA
ACCATTCTTTGATGTATCCCATTCGCTCCATGTTAACATCCAAAACCAGCCTGGATTTCATACATGGACTTCTGATTAAAAGTGGCAGGT

>52653_52653_27_MED1-GSDMB_MED1_chr17_37575970_ENST00000300651_GSDMB_chr17_38062524_ENST00000309481_length(amino acids)=606AA_BP=432
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL
GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI
APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED
MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF

--------------------------------------------------------------
>52653_52653_28_MED1-GSDMB_MED1_chr17_37575970_ENST00000300651_GSDMB_chr17_38062524_ENST00000360317_length(transcript)=2262nt_BP=1521nt
ACGGTTTATCTCGCGAATTTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAG
ATTGATCCTTCCCGGGAAGAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAG
GGCTTATCCTTTTGTGGCGGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGA
TGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGA
AGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAG
CAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAG
ATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTC
CGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGG
ACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTA
ATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATG
TCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCAT
CAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCC
CTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAG
CATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGT
TTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCC
TCAACAAGGATGCTCCTCTTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTC
TTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTT
TGGGTTCGGAGGATTCCAGAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATG
TGCTAAACTCCCTCGCTAAGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGC
TACACATGGAGGACCCAGACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGG
ACTTCCTGGATGCCCTGCTAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACC
AGGTGAAATCTGTCATGGAGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTG
CGCTGTATGTTGTTGTCTCTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAA
GCCTCTGGGTTTTCCCTTTACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCA
ACCATTCTTTGATGTATCCCATTCGCTCCATGTTAACATCCAAAACCAGCCTGGATTTCATACATGGACTTCTGATTAAAAGTGGCAGGT

>52653_52653_28_MED1-GSDMB_MED1_chr17_37575970_ENST00000300651_GSDMB_chr17_38062524_ENST00000360317_length(amino acids)=606AA_BP=432
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL
GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI
APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED
MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF

--------------------------------------------------------------
>52653_52653_29_MED1-GSDMB_MED1_chr17_37575970_ENST00000300651_GSDMB_chr17_38062524_ENST00000394175_length(transcript)=2262nt_BP=1521nt
ACGGTTTATCTCGCGAATTTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAG
ATTGATCCTTCCCGGGAAGAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAG
GGCTTATCCTTTTGTGGCGGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGA
TGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGA
AGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAG
CAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAG
ATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTC
CGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGG
ACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTA
ATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATG
TCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCAT
CAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCC
CTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAG
CATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGT
TTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCC
TCAACAAGGATGCTCCTCTTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTC
TTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTT
TGGGTTCGGAGGATTCCAGAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATG
TGCTAAACTCCCTCGCTAAGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGC
TACACATGGAGGACCCAGACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGG
ACTTCCTGGATGCCCTGCTAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACC
AGGTGAAATCTGTCATGGAGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTG
CGCTGTATGTTGTTGTCTCTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAA
GCCTCTGGGTTTTCCCTTTACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCA
ACCATTCTTTGATGTATCCCATTCGCTCCATGTTAACATCCAAAACCAGCCTGGATTTCATACATGGACTTCTGATTAAAAGTGGCAGGT

>52653_52653_29_MED1-GSDMB_MED1_chr17_37575970_ENST00000300651_GSDMB_chr17_38062524_ENST00000394175_length(amino acids)=606AA_BP=432
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL
GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI
APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED
MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF

--------------------------------------------------------------
>52653_52653_30_MED1-GSDMB_MED1_chr17_37575970_ENST00000300651_GSDMB_chr17_38062524_ENST00000394179_length(transcript)=2260nt_BP=1521nt
ACGGTTTATCTCGCGAATTTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAG
ATTGATCCTTCCCGGGAAGAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAG
GGCTTATCCTTTTGTGGCGGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGA
TGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGA
AGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAG
CAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAG
ATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTC
CGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGG
ACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTA
ATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATG
TCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCAT
CAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCC
CTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAG
CATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGT
TTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCC
TCAACAAGGATGCTCCTCTTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTC
TTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTT
TGGGTTCGGAGGATTCCAGAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATG
TGCTAAACTCCCTCGCTAAGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGC
TACACATGGAGGACCCAGACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGG
ACTTCCTGGATGCCCTGCTAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACC
AGGTGAAATCTGTCATGGAGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTG
CGCTGTATGTTGTTGTCTCTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAA
GCCTCTGGGTTTTCCCTTTACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCA
ACCATTCTTTGATGTATCCCATTCGCTCCATGTTAACATCCAAAACCAGCCTGGATTTCATACATGGACTTCTGATTAAAAGTGGCAGGT

>52653_52653_30_MED1-GSDMB_MED1_chr17_37575970_ENST00000300651_GSDMB_chr17_38062524_ENST00000394179_length(amino acids)=606AA_BP=432
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL
GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI
APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED
MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF

--------------------------------------------------------------
>52653_52653_31_MED1-GSDMB_MED1_chr17_37575970_ENST00000300651_GSDMB_chr17_38062524_ENST00000418519_length(transcript)=2260nt_BP=1521nt
ACGGTTTATCTCGCGAATTTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAG
ATTGATCCTTCCCGGGAAGAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAG
GGCTTATCCTTTTGTGGCGGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGA
TGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGA
AGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAG
CAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAG
ATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTC
CGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGG
ACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTA
ATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATG
TCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCAT
CAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCC
CTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAG
CATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGT
TTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCC
TCAACAAGGATGCTCCTCTTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTC
TTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTT
TGGGTTCGGAGGATTCCAGAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATG
TGCTAAACTCCCTCGCTAAGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGC
TACACATGGAGGACCCAGACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGG
ACTTCCTGGATGCCCTGCTAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACC
AGGTGAAATCTGTCATGGAGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTG
CGCTGTATGTTGTTGTCTCTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAA
GCCTCTGGGTTTTCCCTTTACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCA
ACCATTCTTTGATGTATCCCATTCGCTCCATGTTAACATCCAAAACCAGCCTGGATTTCATACATGGACTTCTGATTAAAAGTGGCAGGT

>52653_52653_31_MED1-GSDMB_MED1_chr17_37575970_ENST00000300651_GSDMB_chr17_38062524_ENST00000418519_length(amino acids)=606AA_BP=432
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL
GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI
APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED
MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF

--------------------------------------------------------------
>52653_52653_32_MED1-GSDMB_MED1_chr17_37575970_ENST00000300651_GSDMB_chr17_38062524_ENST00000520542_length(transcript)=2260nt_BP=1521nt
ACGGTTTATCTCGCGAATTTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAG
ATTGATCCTTCCCGGGAAGAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAG
GGCTTATCCTTTTGTGGCGGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGA
TGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGA
AGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAG
CAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAG
ATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTC
CGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGG
ACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTA
ATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATG
TCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCAT
CAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCC
CTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAG
CATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGT
TTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCC
TCAACAAGGATGCTCCTCTTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTC
TTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTT
TGGGTTCGGAGGATTCCAGAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATG
TGCTAAACTCCCTCGCTAAGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGC
TACACATGGAGGACCCAGACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGG
ACTTCCTGGATGCCCTGCTAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACC
AGGTGAAATCTGTCATGGAGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTG
CGCTGTATGTTGTTGTCTCTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAA
GCCTCTGGGTTTTCCCTTTACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCA
ACCATTCTTTGATGTATCCCATTCGCTCCATGTTAACATCCAAAACCAGCCTGGATTTCATACATGGACTTCTGATTAAAAGTGGCAGGT

>52653_52653_32_MED1-GSDMB_MED1_chr17_37575970_ENST00000300651_GSDMB_chr17_38062524_ENST00000520542_length(amino acids)=606AA_BP=432
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL
GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI
APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED
MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF

--------------------------------------------------------------
>52653_52653_33_MED1-GSDMB_MED1_chr17_37575970_ENST00000300651_GSDMB_chr17_38063240_ENST00000360317_length(transcript)=2289nt_BP=1521nt
ACGGTTTATCTCGCGAATTTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAG
ATTGATCCTTCCCGGGAAGAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAG
GGCTTATCCTTTTGTGGCGGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGA
TGAGTTCTCTCCTGGAACGGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGA
AGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAG
CAATGACTGATCGTTTGGAGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAG
ATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTC
CGGAGCTTGTACAGCAGCTAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGG
ACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTA
ATGCTGGTCCCTTGGATAAGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATG
TCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCAT
CAGTGACAATTGAAGGAACATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCC
CTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAG
CATTTGTTCAGAAACTGCAGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGT
TTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCC
TCAACAAGGATGCTCCTCTTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTC
TTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGAGAAGGATG
GTGCTTCATCCTGTTTAGGAAAGTCTTTGGGTTCGGAGGATTCCAGAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGG
ACCTGACAGAGGAGAAGAGAAAAGATGTGCTAAACTCCCTCGCTAAGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAG
TATCTGAGGTCCTGATTTCCGGGGAGCTACACATGGAGGACCCAGACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGG
TAGAAGCGCGTGCAAAAGCCATTCTGGACTTCCTGGATGCCCTGCTAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGA
AGGGGACCCTTCCTCTGTTGAAGGACCAGGTGAAATCTGTCATGGAGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACT
ATGACCCTGAGGCACGAATTCTCTGTGCGCTGTATGTTGTTGTCTCTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCT
AACTACAAAAGCCCTTTCTCCCCACAAGCCTCTGGGTTTTCCCTTTACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCA
GTGGGACCTCTTTAAAACAAGCAGCCAACCATTCTTTGATGTATCCCATTCGCTCCATGTTAACATCCAAAACCAGCCTGGATTTCATAC

>52653_52653_33_MED1-GSDMB_MED1_chr17_37575970_ENST00000300651_GSDMB_chr17_38063240_ENST00000360317_length(amino acids)=615AA_BP=432
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL
GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI
APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEEKDGASSCLGKSLGSEDS
RNMKEKLEDMESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDAL

--------------------------------------------------------------
>52653_52653_34_MED1-GSDMB_MED1_chr17_37575970_ENST00000394287_GSDMB_chr17_38062524_ENST00000309481_length(transcript)=2244nt_BP=1503nt
TTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAGATTGATCCTTCCCGGGAA
GAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAGGGCTTATCCTTTTGTGGC
GGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAAC
GGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTT
CTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGG
AGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAG
TGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGC
TAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTA
AAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATA
AGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTAC
TGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAA
CATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCA
CCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGC
AGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACC
CTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCCTCAACAAGGATGCTCCTC
TTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTCTTATCCTAAATCTGATCA
GACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTTTGGGTTCGGAGGATTCCA
GAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATGTGCTAAACTCCCTCGCTA
AGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGCTACACATGGAGGACCCAG
ACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGGACTTCCTGGATGCCCTGC
TAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACCAGGTGAAATCTGTCATGG
AGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTGCGCTGTATGTTGTTGTCT
CTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAAGCCTCTGGGTTTTCCCTT
TACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCAACCATTCTTTGATGTATC

>52653_52653_34_MED1-GSDMB_MED1_chr17_37575970_ENST00000394287_GSDMB_chr17_38062524_ENST00000309481_length(amino acids)=606AA_BP=432
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL
GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI
APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED
MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF

--------------------------------------------------------------
>52653_52653_35_MED1-GSDMB_MED1_chr17_37575970_ENST00000394287_GSDMB_chr17_38062524_ENST00000360317_length(transcript)=2244nt_BP=1503nt
TTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAGATTGATCCTTCCCGGGAA
GAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAGGGCTTATCCTTTTGTGGC
GGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAAC
GGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTT
CTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGG
AGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAG
TGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGC
TAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTA
AAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATA
AGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTAC
TGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAA
CATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCA
CCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGC
AGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACC
CTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCCTCAACAAGGATGCTCCTC
TTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTCTTATCCTAAATCTGATCA
GACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTTTGGGTTCGGAGGATTCCA
GAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATGTGCTAAACTCCCTCGCTA
AGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGCTACACATGGAGGACCCAG
ACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGGACTTCCTGGATGCCCTGC
TAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACCAGGTGAAATCTGTCATGG
AGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTGCGCTGTATGTTGTTGTCT
CTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAAGCCTCTGGGTTTTCCCTT
TACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCAACCATTCTTTGATGTATC

>52653_52653_35_MED1-GSDMB_MED1_chr17_37575970_ENST00000394287_GSDMB_chr17_38062524_ENST00000360317_length(amino acids)=606AA_BP=432
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL
GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI
APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED
MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF

--------------------------------------------------------------
>52653_52653_36_MED1-GSDMB_MED1_chr17_37575970_ENST00000394287_GSDMB_chr17_38062524_ENST00000394175_length(transcript)=2244nt_BP=1503nt
TTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAGATTGATCCTTCCCGGGAA
GAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAGGGCTTATCCTTTTGTGGC
GGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAAC
GGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTT
CTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGG
AGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAG
TGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGC
TAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTA
AAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATA
AGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTAC
TGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAA
CATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCA
CCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGC
AGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACC
CTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCCTCAACAAGGATGCTCCTC
TTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTCTTATCCTAAATCTGATCA
GACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTTTGGGTTCGGAGGATTCCA
GAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATGTGCTAAACTCCCTCGCTA
AGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGCTACACATGGAGGACCCAG
ACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGGACTTCCTGGATGCCCTGC
TAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACCAGGTGAAATCTGTCATGG
AGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTGCGCTGTATGTTGTTGTCT
CTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAAGCCTCTGGGTTTTCCCTT
TACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCAACCATTCTTTGATGTATC

>52653_52653_36_MED1-GSDMB_MED1_chr17_37575970_ENST00000394287_GSDMB_chr17_38062524_ENST00000394175_length(amino acids)=606AA_BP=432
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL
GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI
APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED
MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF

--------------------------------------------------------------
>52653_52653_37_MED1-GSDMB_MED1_chr17_37575970_ENST00000394287_GSDMB_chr17_38062524_ENST00000394179_length(transcript)=2242nt_BP=1503nt
TTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAGATTGATCCTTCCCGGGAA
GAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAGGGCTTATCCTTTTGTGGC
GGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAAC
GGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTT
CTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGG
AGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAG
TGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGC
TAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTA
AAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATA
AGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTAC
TGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAA
CATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCA
CCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGC
AGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACC
CTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCCTCAACAAGGATGCTCCTC
TTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTCTTATCCTAAATCTGATCA
GACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTTTGGGTTCGGAGGATTCCA
GAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATGTGCTAAACTCCCTCGCTA
AGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGCTACACATGGAGGACCCAG
ACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGGACTTCCTGGATGCCCTGC
TAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACCAGGTGAAATCTGTCATGG
AGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTGCGCTGTATGTTGTTGTCT
CTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAAGCCTCTGGGTTTTCCCTT
TACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCAACCATTCTTTGATGTATC

>52653_52653_37_MED1-GSDMB_MED1_chr17_37575970_ENST00000394287_GSDMB_chr17_38062524_ENST00000394179_length(amino acids)=606AA_BP=432
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL
GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI
APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED
MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF

--------------------------------------------------------------
>52653_52653_38_MED1-GSDMB_MED1_chr17_37575970_ENST00000394287_GSDMB_chr17_38062524_ENST00000418519_length(transcript)=2242nt_BP=1503nt
TTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAGATTGATCCTTCCCGGGAA
GAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAGGGCTTATCCTTTTGTGGC
GGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAAC
GGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTT
CTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGG
AGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAG
TGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGC
TAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTA
AAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATA
AGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTAC
TGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAA
CATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCA
CCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGC
AGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACC
CTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCCTCAACAAGGATGCTCCTC
TTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTCTTATCCTAAATCTGATCA
GACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTTTGGGTTCGGAGGATTCCA
GAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATGTGCTAAACTCCCTCGCTA
AGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGCTACACATGGAGGACCCAG
ACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGGACTTCCTGGATGCCCTGC
TAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACCAGGTGAAATCTGTCATGG
AGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTGCGCTGTATGTTGTTGTCT
CTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAAGCCTCTGGGTTTTCCCTT
TACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCAACCATTCTTTGATGTATC

>52653_52653_38_MED1-GSDMB_MED1_chr17_37575970_ENST00000394287_GSDMB_chr17_38062524_ENST00000418519_length(amino acids)=606AA_BP=432
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL
GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI
APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED
MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF

--------------------------------------------------------------
>52653_52653_39_MED1-GSDMB_MED1_chr17_37575970_ENST00000394287_GSDMB_chr17_38062524_ENST00000520542_length(transcript)=2242nt_BP=1503nt
TTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAGATTGATCCTTCCCGGGAA
GAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAGGGCTTATCCTTTTGTGGC
GGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAAC
GGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTT
CTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGG
AGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAG
TGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGC
TAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTA
AAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATA
AGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTAC
TGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAA
CATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCA
CCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGC
AGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACC
CTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCCTCAACAAGGATGCTCCTC
TTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTCTTATCCTAAATCTGATCA
GACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGGAAAGTCTTTGGGTTCGGAGGATTCCA
GAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATGTGCTAAACTCCCTCGCTA
AGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGCTACACATGGAGGACCCAG
ACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGGACTTCCTGGATGCCCTGC
TAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACCAGGTGAAATCTGTCATGG
AGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTGCGCTGTATGTTGTTGTCT
CTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAAGCCTCTGGGTTTTCCCTT
TACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCAACCATTCTTTGATGTATC

>52653_52653_39_MED1-GSDMB_MED1_chr17_37575970_ENST00000394287_GSDMB_chr17_38062524_ENST00000520542_length(amino acids)=606AA_BP=432
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL
GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI
APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGKSLGSEDSRNMKEKLED
MESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQF

--------------------------------------------------------------
>52653_52653_40_MED1-GSDMB_MED1_chr17_37575970_ENST00000394287_GSDMB_chr17_38063240_ENST00000360317_length(transcript)=2271nt_BP=1503nt
TTTGGGAAGTTCCGTTGGGGAAGATGGCGGCGGCCTCGAGCACCCTTCTCTTCTTGCCGCCGGGGACTTCAGATTGATCCTTCCCGGGAA
GAGTAGGGACTGCTGGTGCCCTGCGTCCCGGGATCCCGAGCCAACTTGTTTCCTCCGTTAGTGGTGGGGAAGGGCTTATCCTTTTGTGGC
GGATCTAGCTTCTCCTCGCCTTCAGGATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTGGAAC
GGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTGCGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTT
CTGGAGGGCATCAACATTTGGTCAGCTGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGTTTGG
AGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAATGTTACATCACGTCAGATATGTTCTATGTGGAAG
TGCAGTTAGATCCTGCAGGACAGCTTTGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAGCAGC
TAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTGTATAACCTTCCAGGGGACAACAAACTGAAGACTA
AAATGTACTTGGCTCTCCAATCCTTAGAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTGGATA
AGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATGAACCTGAAGTACTATGTCTCTCCTTCTGACCTAC
TGGATGACAAGACTGCATCTCCCATCATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAAGGAA
CATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTTGACAATAAATGGACCCCTTCCTTCTCCTCAATCA
CCAGTGCCAACAGTGTTGATCTTCCTGCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAACTGC
AGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTATGAACTGATCACTCAGTTTGAGCTATCAAAGGACC
CTGACCCCATACCTTTGAATCACAACATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCCTCAACAAGGATGCTCCTC
TTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCACCCTGGCCGAGTTCCTCTTATCCTAAATCTGATCA
GACACCAAGTGGCCTATAACACCCTCATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGAGAAGGATGGTGCTTCATCCTGTTTAG
GAAAGTCTTTGGGTTCGGAGGATTCCAGAAACATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGA
GAAAAGATGTGCTAAACTCCCTCGCTAAGTGCCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTT
CCGGGGAGCTACACATGGAGGACCCAGACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAG
CCATTCTGGACTTCCTGGATGCCCTGCTAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGT
TGAAGGACCAGGTGAAATCTGTCATGGAGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAA
TTCTCTGTGCGCTGTATGTTGTTGTCTCTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTC
TCCCCACAAGCCTCTGGGTTTTCCCTTTACCAGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAAC
AAGCAGCCAACCATTCTTTGATGTATCCCATTCGCTCCATGTTAACATCCAAAACCAGCCTGGATTTCATACATGGACTTCTGATTAAAA

>52653_52653_40_MED1-GSDMB_MED1_chr17_37575970_ENST00000394287_GSDMB_chr17_38063240_ENST00000360317_length(amino acids)=615AA_BP=432
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGL
GSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPI
APLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEEKDGASSCLGKSLGSEDS
RNMKEKLEDMESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDAL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MED1-GSDMB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneMED1chr17:37575969chr17:38062523ENST00000300651-1417108_212432.33333333333331582.0the Mediator complex
HgeneMED1chr17:37575969chr17:38062523ENST00000300651-1417215_390432.33333333333331582.0the Mediator complex
HgeneMED1chr17:37575969chr17:38062523ENST00000394287-1418108_212432.3333333333333557.0the Mediator complex
HgeneMED1chr17:37575969chr17:38062523ENST00000394287-1418215_390432.3333333333333557.0the Mediator complex
HgeneMED1chr17:37575969chr17:38062524ENST00000300651-1417108_212432.33333333333331582.0the Mediator complex
HgeneMED1chr17:37575969chr17:38062524ENST00000300651-1417215_390432.33333333333331582.0the Mediator complex
HgeneMED1chr17:37575969chr17:38062524ENST00000394287-1418108_212432.3333333333333557.0the Mediator complex
HgeneMED1chr17:37575969chr17:38062524ENST00000394287-1418215_390432.3333333333333557.0the Mediator complex
HgeneMED1chr17:37575969chr17:38063239ENST00000300651-1417108_212432.33333333333331582.0the Mediator complex
HgeneMED1chr17:37575969chr17:38063239ENST00000300651-1417215_390432.33333333333331582.0the Mediator complex
HgeneMED1chr17:37575969chr17:38063239ENST00000394287-1418108_212432.3333333333333557.0the Mediator complex
HgeneMED1chr17:37575969chr17:38063239ENST00000394287-1418215_390432.3333333333333557.0the Mediator complex
HgeneMED1chr17:37575970chr17:38062524ENST00000300651-1417108_212432.33333333333331582.0the Mediator complex
HgeneMED1chr17:37575970chr17:38062524ENST00000300651-1417215_390432.33333333333331582.0the Mediator complex
HgeneMED1chr17:37575970chr17:38062524ENST00000394287-1418108_212432.3333333333333557.0the Mediator complex
HgeneMED1chr17:37575970chr17:38062524ENST00000394287-1418215_390432.3333333333333557.0the Mediator complex
HgeneMED1chr17:37575970chr17:38063240ENST00000300651-1417108_212432.33333333333331582.0the Mediator complex
HgeneMED1chr17:37575970chr17:38063240ENST00000300651-1417215_390432.33333333333331582.0the Mediator complex
HgeneMED1chr17:37575970chr17:38063240ENST00000394287-1418108_212432.3333333333333557.0the Mediator complex
HgeneMED1chr17:37575970chr17:38063240ENST00000394287-1418215_390432.3333333333333557.0the Mediator complex


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMED1chr17:37575969chr17:38062523ENST00000300651-141716_590432.33333333333331582.0ESR1
HgeneMED1chr17:37575969chr17:38062523ENST00000300651-1417656_1066432.33333333333331582.0ESR1
HgeneMED1chr17:37575969chr17:38062523ENST00000394287-141816_590432.3333333333333557.0ESR1
HgeneMED1chr17:37575969chr17:38062523ENST00000394287-1418656_1066432.3333333333333557.0ESR1
HgeneMED1chr17:37575969chr17:38062524ENST00000300651-141716_590432.33333333333331582.0ESR1
HgeneMED1chr17:37575969chr17:38062524ENST00000300651-1417656_1066432.33333333333331582.0ESR1
HgeneMED1chr17:37575969chr17:38062524ENST00000394287-141816_590432.3333333333333557.0ESR1
HgeneMED1chr17:37575969chr17:38062524ENST00000394287-1418656_1066432.3333333333333557.0ESR1
HgeneMED1chr17:37575969chr17:38063239ENST00000300651-141716_590432.33333333333331582.0ESR1
HgeneMED1chr17:37575969chr17:38063239ENST00000300651-1417656_1066432.33333333333331582.0ESR1
HgeneMED1chr17:37575969chr17:38063239ENST00000394287-141816_590432.3333333333333557.0ESR1
HgeneMED1chr17:37575969chr17:38063239ENST00000394287-1418656_1066432.3333333333333557.0ESR1
HgeneMED1chr17:37575970chr17:38062524ENST00000300651-141716_590432.33333333333331582.0ESR1
HgeneMED1chr17:37575970chr17:38062524ENST00000300651-1417656_1066432.33333333333331582.0ESR1
HgeneMED1chr17:37575970chr17:38062524ENST00000394287-141816_590432.3333333333333557.0ESR1
HgeneMED1chr17:37575970chr17:38062524ENST00000394287-1418656_1066432.3333333333333557.0ESR1
HgeneMED1chr17:37575970chr17:38063240ENST00000300651-141716_590432.33333333333331582.0ESR1
HgeneMED1chr17:37575970chr17:38063240ENST00000300651-1417656_1066432.33333333333331582.0ESR1
HgeneMED1chr17:37575970chr17:38063240ENST00000394287-141816_590432.3333333333333557.0ESR1
HgeneMED1chr17:37575970chr17:38063240ENST00000394287-1418656_1066432.3333333333333557.0ESR1
HgeneMED1chr17:37575969chr17:38062523ENST00000300651-1417681_715432.33333333333331582.0GATA1
HgeneMED1chr17:37575969chr17:38062523ENST00000394287-1418681_715432.3333333333333557.0GATA1
HgeneMED1chr17:37575969chr17:38062524ENST00000300651-1417681_715432.33333333333331582.0GATA1
HgeneMED1chr17:37575969chr17:38062524ENST00000394287-1418681_715432.3333333333333557.0GATA1
HgeneMED1chr17:37575969chr17:38063239ENST00000300651-1417681_715432.33333333333331582.0GATA1
HgeneMED1chr17:37575969chr17:38063239ENST00000394287-1418681_715432.3333333333333557.0GATA1
HgeneMED1chr17:37575970chr17:38062524ENST00000300651-1417681_715432.33333333333331582.0GATA1
HgeneMED1chr17:37575970chr17:38062524ENST00000394287-1418681_715432.3333333333333557.0GATA1
HgeneMED1chr17:37575970chr17:38063240ENST00000300651-1417681_715432.33333333333331582.0GATA1
HgeneMED1chr17:37575970chr17:38063240ENST00000394287-1418681_715432.3333333333333557.0GATA1
HgeneMED1chr17:37575969chr17:38062523ENST00000300651-1417622_701432.33333333333331582.0PPARGC1A and THRA
HgeneMED1chr17:37575969chr17:38062523ENST00000394287-1418622_701432.3333333333333557.0PPARGC1A and THRA
HgeneMED1chr17:37575969chr17:38062524ENST00000300651-1417622_701432.33333333333331582.0PPARGC1A and THRA
HgeneMED1chr17:37575969chr17:38062524ENST00000394287-1418622_701432.3333333333333557.0PPARGC1A and THRA
HgeneMED1chr17:37575969chr17:38063239ENST00000300651-1417622_701432.33333333333331582.0PPARGC1A and THRA
HgeneMED1chr17:37575969chr17:38063239ENST00000394287-1418622_701432.3333333333333557.0PPARGC1A and THRA
HgeneMED1chr17:37575970chr17:38062524ENST00000300651-1417622_701432.33333333333331582.0PPARGC1A and THRA
HgeneMED1chr17:37575970chr17:38062524ENST00000394287-1418622_701432.3333333333333557.0PPARGC1A and THRA
HgeneMED1chr17:37575970chr17:38063240ENST00000300651-1417622_701432.33333333333331582.0PPARGC1A and THRA
HgeneMED1chr17:37575970chr17:38063240ENST00000394287-1418622_701432.3333333333333557.0PPARGC1A and THRA
HgeneMED1chr17:37575969chr17:38062523ENST00000300651-14171_670432.33333333333331582.0the Mediator complex and THRA
HgeneMED1chr17:37575969chr17:38062523ENST00000394287-14181_670432.3333333333333557.0the Mediator complex and THRA
HgeneMED1chr17:37575969chr17:38062524ENST00000300651-14171_670432.33333333333331582.0the Mediator complex and THRA
HgeneMED1chr17:37575969chr17:38062524ENST00000394287-14181_670432.3333333333333557.0the Mediator complex and THRA
HgeneMED1chr17:37575969chr17:38063239ENST00000300651-14171_670432.33333333333331582.0the Mediator complex and THRA
HgeneMED1chr17:37575969chr17:38063239ENST00000394287-14181_670432.3333333333333557.0the Mediator complex and THRA
HgeneMED1chr17:37575970chr17:38062524ENST00000300651-14171_670432.33333333333331582.0the Mediator complex and THRA
HgeneMED1chr17:37575970chr17:38062524ENST00000394287-14181_670432.3333333333333557.0the Mediator complex and THRA
HgeneMED1chr17:37575970chr17:38063240ENST00000300651-14171_670432.33333333333331582.0the Mediator complex and THRA
HgeneMED1chr17:37575970chr17:38063240ENST00000394287-14181_670432.3333333333333557.0the Mediator complex and THRA
HgeneMED1chr17:37575969chr17:38062523ENST00000300651-1417405_644432.33333333333331582.0THRA
HgeneMED1chr17:37575969chr17:38062523ENST00000394287-1418405_644432.3333333333333557.0THRA
HgeneMED1chr17:37575969chr17:38062524ENST00000300651-1417405_644432.33333333333331582.0THRA
HgeneMED1chr17:37575969chr17:38062524ENST00000394287-1418405_644432.3333333333333557.0THRA
HgeneMED1chr17:37575969chr17:38063239ENST00000300651-1417405_644432.33333333333331582.0THRA
HgeneMED1chr17:37575969chr17:38063239ENST00000394287-1418405_644432.3333333333333557.0THRA
HgeneMED1chr17:37575970chr17:38062524ENST00000300651-1417405_644432.33333333333331582.0THRA
HgeneMED1chr17:37575970chr17:38062524ENST00000394287-1418405_644432.3333333333333557.0THRA
HgeneMED1chr17:37575970chr17:38063240ENST00000300651-1417405_644432.33333333333331582.0THRA
HgeneMED1chr17:37575970chr17:38063240ENST00000394287-1418405_644432.3333333333333557.0THRA
HgeneMED1chr17:37575969chr17:38062523ENST00000300651-14171249_1421432.33333333333331582.0TP53
HgeneMED1chr17:37575969chr17:38062523ENST00000394287-14181249_1421432.3333333333333557.0TP53
HgeneMED1chr17:37575969chr17:38062524ENST00000300651-14171249_1421432.33333333333331582.0TP53
HgeneMED1chr17:37575969chr17:38062524ENST00000394287-14181249_1421432.3333333333333557.0TP53
HgeneMED1chr17:37575969chr17:38063239ENST00000300651-14171249_1421432.33333333333331582.0TP53
HgeneMED1chr17:37575969chr17:38063239ENST00000394287-14181249_1421432.3333333333333557.0TP53
HgeneMED1chr17:37575970chr17:38062524ENST00000300651-14171249_1421432.33333333333331582.0TP53
HgeneMED1chr17:37575970chr17:38062524ENST00000394287-14181249_1421432.3333333333333557.0TP53
HgeneMED1chr17:37575970chr17:38063240ENST00000300651-14171249_1421432.33333333333331582.0TP53
HgeneMED1chr17:37575970chr17:38063240ENST00000394287-14181249_1421432.3333333333333557.0TP53
HgeneMED1chr17:37575969chr17:38062523ENST00000300651-1417542_789432.33333333333331582.0VDR
HgeneMED1chr17:37575969chr17:38062523ENST00000394287-1418542_789432.3333333333333557.0VDR
HgeneMED1chr17:37575969chr17:38062524ENST00000300651-1417542_789432.33333333333331582.0VDR
HgeneMED1chr17:37575969chr17:38062524ENST00000394287-1418542_789432.3333333333333557.0VDR
HgeneMED1chr17:37575969chr17:38063239ENST00000300651-1417542_789432.33333333333331582.0VDR
HgeneMED1chr17:37575969chr17:38063239ENST00000394287-1418542_789432.3333333333333557.0VDR
HgeneMED1chr17:37575970chr17:38062524ENST00000300651-1417542_789432.33333333333331582.0VDR
HgeneMED1chr17:37575970chr17:38062524ENST00000394287-1418542_789432.3333333333333557.0VDR
HgeneMED1chr17:37575970chr17:38063240ENST00000300651-1417542_789432.33333333333331582.0VDR
HgeneMED1chr17:37575970chr17:38063240ENST00000394287-1418542_789432.3333333333333557.0VDR


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MED1-GSDMB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MED1-GSDMB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource