|
||||||
|
 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:AP3B1-DCTN4 (FusionGDB2 ID:5266) |
Fusion Gene Summary for AP3B1-DCTN4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AP3B1-DCTN4 | Fusion gene ID: 5266 | Hgene | Tgene | Gene symbol | AP3B1 | DCTN4 | Gene ID | 8546 | 51164 |
| Gene name | adaptor related protein complex 3 subunit beta 1 | dynactin subunit 4 | |
| Synonyms | ADTB3|ADTB3A|HPS|HPS2|PE | DYN4|P62 | |
| Cytomap | 5q14.1 | 5q33.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | AP-3 complex subunit beta-1AP-3 complex beta-3A subunitadaptor protein complex AP-3 subunit beta-1adaptor related protein complex 3 beta 1 subunitbeta-3A-adaptinclathrin assembly protein complex 3 beta-1 large chain | dynactin subunit 4dynactin 4 (p62)dynactin p62 subunitdynactin subunit p62 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | O00203 | Q9UJW0 | |
| Ensembl transtripts involved in fusion gene | ENST00000255194, ENST00000519295, ENST00000523204, | ENST00000424236, ENST00000446090, ENST00000521093, ENST00000447998, | |
| Fusion gene scores | * DoF score | 10 X 12 X 6=720 | 5 X 7 X 4=140 |
| # samples | 12 | 7 | |
| ** MAII score | log2(12/720*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/140*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: AP3B1 [Title/Abstract] AND DCTN4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | AP3B1(77423854)-DCTN4(150136049), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across AP3B1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene breakpoints across DCTN4 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | KIRC | TCGA-BP-4986-01A | AP3B1 | chr5 | 77423854 | - | DCTN4 | chr5 | 150136049 | - |
Top |
Fusion Gene ORF analysis for AP3B1-DCTN4 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000255194 | ENST00000424236 | AP3B1 | chr5 | 77423854 | - | DCTN4 | chr5 | 150136049 | - |
| 5CDS-5UTR | ENST00000255194 | ENST00000446090 | AP3B1 | chr5 | 77423854 | - | DCTN4 | chr5 | 150136049 | - |
| 5CDS-5UTR | ENST00000255194 | ENST00000521093 | AP3B1 | chr5 | 77423854 | - | DCTN4 | chr5 | 150136049 | - |
| 5CDS-5UTR | ENST00000519295 | ENST00000424236 | AP3B1 | chr5 | 77423854 | - | DCTN4 | chr5 | 150136049 | - |
| 5CDS-5UTR | ENST00000519295 | ENST00000446090 | AP3B1 | chr5 | 77423854 | - | DCTN4 | chr5 | 150136049 | - |
| 5CDS-5UTR | ENST00000519295 | ENST00000521093 | AP3B1 | chr5 | 77423854 | - | DCTN4 | chr5 | 150136049 | - |
| In-frame | ENST00000255194 | ENST00000447998 | AP3B1 | chr5 | 77423854 | - | DCTN4 | chr5 | 150136049 | - |
| In-frame | ENST00000519295 | ENST00000447998 | AP3B1 | chr5 | 77423854 | - | DCTN4 | chr5 | 150136049 | - |
| intron-3CDS | ENST00000523204 | ENST00000447998 | AP3B1 | chr5 | 77423854 | - | DCTN4 | chr5 | 150136049 | - |
| intron-5UTR | ENST00000523204 | ENST00000424236 | AP3B1 | chr5 | 77423854 | - | DCTN4 | chr5 | 150136049 | - |
| intron-5UTR | ENST00000523204 | ENST00000446090 | AP3B1 | chr5 | 77423854 | - | DCTN4 | chr5 | 150136049 | - |
| intron-5UTR | ENST00000523204 | ENST00000521093 | AP3B1 | chr5 | 77423854 | - | DCTN4 | chr5 | 150136049 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000255194 | AP3B1 | chr5 | 77423854 | - | ENST00000447998 | DCTN4 | chr5 | 150136049 | - | 6101 | 2144 | 65 | 3391 | 1108 |
| ENST00000519295 | AP3B1 | chr5 | 77423854 | - | ENST00000447998 | DCTN4 | chr5 | 150136049 | - | 6050 | 2093 | 272 | 3340 | 1022 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000255194 | ENST00000447998 | AP3B1 | chr5 | 77423854 | - | DCTN4 | chr5 | 150136049 | - | 0.00019585 | 0.9998042 |
| ENST00000519295 | ENST00000447998 | AP3B1 | chr5 | 77423854 | - | DCTN4 | chr5 | 150136049 | - | 0.000208563 | 0.99979144 |
Top |
Fusion Genomic Features for AP3B1-DCTN4 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
Top |
Fusion Protein Features for AP3B1-DCTN4 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:77423854/chr5:150136049) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AP3B1 | DCTN4 |
| FUNCTION: Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. {ECO:0000305|PubMed:9151686}. | FUNCTION: Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | DCTN4 | chr5:77423854 | chr5:150136049 | ENST00000424236 | 0 | 13 | 152_172 | 0 | 404.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | DCTN4 | chr5:77423854 | chr5:150136049 | ENST00000446090 | 0 | 14 | 152_172 | 45 | 468.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | DCTN4 | chr5:77423854 | chr5:150136049 | ENST00000447998 | 0 | 13 | 152_172 | 45 | 461.0 | Coiled coil | Ontology_term=ECO:0000255 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | AP3B1 | chr5:77423854 | chr5:150136049 | ENST00000255194 | - | 17 | 27 | 677_802 | 656 | 1095.0 | Compositional bias | Note=Glu/Ser-rich |
Top |
Fusion Gene Sequence for AP3B1-DCTN4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >5266_5266_1_AP3B1-DCTN4_AP3B1_chr5_77423854_ENST00000255194_DCTN4_chr5_150136049_ENST00000447998_length(transcript)=6101nt_BP=2144nt ACTGCGCATGCGCAGGGGGTGGACTGCCAGGTCGGCTCAGGGAGCCGTGACGAGTCCGGAAGCGCCTGCGCGCGCTCCTCCGTACGAGAA CTAGTTTTGTTCCGTGCCCTCTGGACTGGAACCTTTTGGAGAGAACCCCCGGCAGGACCAACCCCGCACCCGCCAGCACCGCGGCAATGT CCAGCAATAGTTTTCCTTACAATGAGCAGTCCGGAGGAGGGGAGGCGACGGAGCTGGGTCAGGAGGCGACCTCAACCATTTCCCCCTCGG GGGCCTTCGGCCTCTTTAGCAGCGATTTGAAGAAGAATGAAGATCTAAAGCAAATGTTAGAGAGCAACAAAGATTCTGCTAAACTGGATG CTATGAAGCGGATTGTTGGGATGATTGCAAAAGGGAAAAATGCATCTGAACTGTTTCCTGCTGTTGTGAAGAATGTGGCCAGTAAAAATA TTGAGATCAAGAAGTTGGTATATGTTTACCTGGTTCGATATGCTGAAGAACAGCAGGATCTTGCACTCCTGTCCATAAGCACTTTTCAGC GAGCTCTGAAGGACCCAAACCAACTAATTCGTGCAAGCGCTTTGAGAGTTCTGTCAAGTATTAGAGTGCCAATTATTGTACCTATCATGA TGCTTGCTATTAAGGAAGCTTCTGCTGACTTATCACCATATGTTAGGAAGAATGCAGCCCATGCAATACAAAAATTATACAGCCTTGATC CAGAGCAGAAGGAAATGTTAATTGAAGTAATTGAAAAACTTCTGAAAGATAAAAGCACATTGGTAGCTGGCAGTGTTGTGATGGCTTTTG AAGAAGTATGCCCGGACAGAATAGATCTGATTCATAAAAATTACCGCAAGCTATGTAACTTACTAGTGGATGTTGAAGAGTGGGGGCAGG TTGTCATAATCCACATGCTAACTCGATATGCTCGGACACAGTTTGTCAGCCCTTGGAAAGAGGGTGATGAATTAGAAGACAATGGAAAGA ATTTCTACGAATCTGATGATGATCAGAAGGAAAAGACTGACAAAAAGAAGAAGCCGTATACTATGGATCCAGATCATAGACTCTTAATTA GAAATACAAAGCCTTTGCTTCAGAGCAGGAATGCTGCGGTGGTTATGGCAGTTGCTCAGCTGTATTGGCACATATCACCAAAATCTGAAG CTGGCATAATTTCTAAATCACTAGTGCGTTTACTTCGTAGCAATAGGGAGGTGCAGTATATTGTCCTACAAAATATAGCAACTATGTCAA TTCAAAGAAAGGGGATGTTTGAACCTTATCTGAAGAGTTTCTATGTTAGGTCAACTGATCCAACTATGATCAAGACACTGAAGCTTGAAA TTTTGACAAACTTGGCAAATGAAGCCAACATATCAACTCTTCTTCGAGAATTTCAGACCTATGTGAAAAGCCAGGATAAACAATTTGCAG CAGCCACTATTCAGACTATAGGCAGATGTGCAACCAACATCTTGGAAGTCACTGACACGTGCCTCAATGGCTTGGTCTGTCTGCTGTCCA ACAGGGATGAAATAGTTGTTGCTGAAAGTGTGGTTGTTATAAAGAAATTACTGCAAATGCAACCTGCACAACATGGTGAAATTATTAAAC ATATGGCCAAACTCCTGGACAGTATCACTGTTCCTGTTGCTAGAGCAAGTATTCTTTGGCTAATTGGAGAAAACTGTGAACGAGTTCCTA AAATTGCCCCTGATGTTTTGAGGAAGATGGCTAAAAGCTTCACTAGTGAAGATGATCTGGTAAAACTGCAGATATTAAATCTGGGAGCAA AATTGTATTTAACCAACTCCAAACAGACAAAATTGCTTACCCAGTACATATTAAATCTCGGCAAGTATGATCAAAACTACGACATCAGAG ACCGTACAAGATTTATTAGGCAGCTTATTGTTCCGAATGTAAAGAGTGGAGCTTTAAGTAAATATGCCAAAAAAATATTCCTAGCACAAA AGCCTGCACCACTGCTTGAGTCTCCTTTTAAAGATAGAGATCATTTCCAGCTTGGCACCTTATCTCATACTCTCAACATTAAAGCTACTG GGTACCTGGAATTATCTAATTGGCCAGAGGTGGCGCCCGACCCATCAGTTCGAAATGTAGAAGTAATAGAGTTGGTGGACTCCCATTATT GTCCCAGTTGTTTAGAAAATATGCCATCGGCTGAAGCCAAACTAAAAAAGAATAGATGTGCCAATTGTTTTGACTGTCCTGGCTGCATGC ACACCCTCTCTACTCGGGCCACGAGCATCTCCACACAGCTTCCAGATGACCCAGCCAAGACCACCATGAAGAAAGCCTATTACCTGGCAT GTGGATTTTGTCGCTGGACGTCTAGAGATGTGGGCATGGCAGACAAATCTGTAGCTAGTGGCGGTTGGCAGGAACCTGAAAATCCTCACA CACAACGGATGAACAAATTGATTGAATATTACCAGCAGCTTGCTCAGAAAGAGAAGGTTGAGCGAGATCGCAAGAAACTGGCACGACGTA GAAACTATATGCCTCTGGCTTTTTCGGACAAATATGGTCTTGGAACCAGGCTTCAGCGACCACGAGCTGGTGCATCCATCAGTACCCTTG CCGGACTTTCCCTTAAAGAAGGAGAGGATCAGAAAGAGATAAAGATTGAGCCAGCTCAGGCTGTGGATGAAGTGGAACCTCTACCTGAAG ACTATTATACAAGACCAGTAAATTTAACAGAGGTAACAACCCTTCAGCAGCGTCTGTTACAGCCTGACTTCCAGCCAGTCTGTGCTTCAC AGCTCTATCCTCGCCACAAACATCTTCTGATCAAACGGTCCCTGCGCTGCCGTAAATGTGAACATAATTTGAGCAAGCCAGAATTTAACC CAACGTCAATCAAATTCAAAATCCAGCTGGTCGCTGTCAATTATATTCCAGAAGTGAGAATCATGTCAATTCCCAACCTTCGCTACATGA AGGAGAGCCAGGTCCTCCTGACTCTTACAAATCCAGTTGAGAACCTCACCCATGTGACTCTCTTCGAGTGTGAGGAGGGGGACCCTGATG ATATCAACAGCACTGCTAAGGTGGTGGTGCCTCCCAAAGAGCTCGTTTTAGCTGGCAAGGATGCAGCAGCAGAGTACGATGAGTTGGCAG AACCTCAAGACTTTCAGGACGATCCTGACATTATAGCCTTCAGAAAGGCCAACAAAGTGGGTATTTTCATCAAAGTTACACCACAGCGTG AGGAGGGTGAAGTGACCGTGTGCTTCAAGATGAAGCATGATTTTAAAAACCTGGCAGCCCCCATTCGCCCCATTGAAGAAAGTGACCAGG GAACAGAAGTCATCTGGCTCACCCAGCATGTGGAACTTAGCTTGGGCCCACTTCTTCCTTAAAAGGTTCCACTGGAGGGCAGATCCCAAA GGACAGTATCACCGTAAACCTGCGTTAAAATGTGGAAGCTGCTGCTTCATTAGGCCTTGTTTATAACGATGTACCCATGCACTACGGAAT TCTATTGCTAAGAAAGTGGGAGCATAGGCAAGGCATTGGGAACACAGGGTAGCTGCTGTTGCTCTTGCTCTCACCCCTGTTGACACCAGT AAGTCTGTGTCTCCCTCACTGAACCCTGCACGTTGAGTAACAGCAGCATAATTCCATCCTAGGAAAGGGGATGGGTGTTCCTTGGAATGG CATTGTATTTACCACCTGAGAAACTCTGTACTGTCTCTTGATCTGATCTCACTAAGGATCACAATGTCACAGATGAAACTTAAATGATAA CCCAAAGGTAGACCTGCTGTTAATGATCCAGCATTGGTCACAATGTACCAACTGCTTTCTGCATTCCGTTAAATATCATCTAACAGTCTA AAACATATCCCTTCATTGCCATAATGGCTGCCATTTTGCCATAGATTTCCATATAACTGAAAAACTGAATTGTCACTTTATCTTTAGTAT CATGATGATTGGAAAAACCTGTGAAGTTGTTAAGGCACTCTCATTTGCCCTCTTTTTCTAAGTGAATACAGGACACGTATTAGTTGTTCT TAATTTTTTTCCCAGTAAAATATGGATCTTTTAAGAAGAATTTGAGAAGCAAACAATTACATGTCATGTCAAGGGGGTAGCAGATTCCAT TCGTTTTCAATATTGCCACAATACCCAGGGATTAATGCTGCCACAGGGGGGCAATCTTTATTTGTCTTACTTCCTACCCCTTCCCTGTTC TGCCTCTTTAACTCAGTTAAGTTGTTCTGTTTGGGACCTGGAAAAGAACCCAAAGAAAACCTGAGTGGACAGGTTCATTTCTGGAATGCA GAAAACATTTTAAAGGCTAGATTTTTAGAATATTCTCAACTAGCATTCTTTCCATTGATTTGAAGGGGAAATTAACTATTATAATCTCTT GAATCCAAAACTGGATATTAAGAACTTTCCCCCTTACTAAGTTTAAGACTTTTGTCATGTGGTGAGTCAAATAAGACCATTTTGATTGTA AACCATAAAATAGTTCAGCAAGTAGCCCACAGTTCTGGCCTAACAGCAGACTTGCTGTTTTCACTTGGTATCCTGGAGTTGGGTTGCTAA CCTTAATTTCTATGATGTTTTCTAAAATGAAACTTGATAAAGTAGACCACCAGCTGCACCGTGTTTTCTGTAAAAGTATTGTTAGTAAGT GGCCAAGAGACTTGAGGAAAATACAGATTTTTTGTTTACCTTGGTCTTGTTTTAAGTCTTAAAAAATTAAAGATAACATTATAATGTAGA ATACAGATGGGACATAGTCCTTGTAAGCTTCCCTTGAAAATGTTTTAAATATTTAGGAAGCTTTTAAAAGACACTAAATTGTACTCTAAA AGACACTAAATTGTACTAATTGTACAAAGGTCAAGCCAATTTTATGAAACAGTCCTACAGAGTAATATATGTGATGCAGTGTAAGAAGGA AAATACTCATCTCTAACATTATGGTAATAACATTTAGCCTCTTAGGAGTTGGAGCAGGGGGATGGGTAATTACAGATTTGCAGACTATAG AAAGAGTTTCATTTTTTTGTGACCCCACAGAGTCTCAAATTTTTATTTCACTACCTGCTAGAGCCTACTGTGAAATCACTGCTCCATATT TGCCAGTGGAGGAAATGGGCATAGAGTAGAGAATAGCTTCATATGTTTACACGTTTGCATAGACTACACACATGTCATGCGTTTATGGCA GGTAGCTGGTATTTATTCCCCAAAGTAATAATGTTGAAGTATGGGTCTCATCATTCCCATACACAGAAACACAAAACACTTTGATCATAA ACTTTTTTCTTCAGAAGCCAAACTAACTTGCAGAATAATAGAGCCACTGGTTTAATGTTTCCTCAAGATAGGTTTTAGTGTAAGCTAGTA TTCTGTGTGTTCGTAGAAATGATTCAATACCTGCAGCTGGTGAATTAGGAATTGTATTTGTTGCCTTTTTTATATTAGATGAGGTGCAAA AATTTTAATGCTAGTCAGTATGCACCACCACAGGAAAGTTAGATCCCATTAGCACTTGAAACTACAGCTTTGGAAACTTAGGCTAAGTTA ATTTGGATTTGTTACTTGATTCACCTACTGACCTTTTCTTTTGTTTGAAGTGCTTATCAGCATAATGAGCTAAGTGTCATGCATATTTGT GAAGAAACACCCTTTTTGGTCCCTTTTGGGACAGAGAGGTACTCCTTGATCTTTATGAATGACAGGTTACTGTTTTGCCTTATTGCTTAA CTTAATGTAGTGAAATAAAGCAGACAAAGCTTGAGCGTGTCTTTTGTTTGCTCTCATGTAGATACTAAGTAGCATGGCTCAGAGCCAAAA GACAAGCGTGAAGTTAAGAGAGTTGGCTAAGAGAGTTGGTGGGGCATGCTCCCTTCCATTCCTTAAATGAAGTAATCTAAAATCTCTTAG CAGGTTAGTTCACCATAATATATAAGTAGATGTTGCTTTGAGCTTCTTATATACATATTCACAGAACCATTATATAAATGTTGTTAGACC >5266_5266_1_AP3B1-DCTN4_AP3B1_chr5_77423854_ENST00000255194_DCTN4_chr5_150136049_ENST00000447998_length(amino acids)=1108AA_BP=693 MRALLRTRTSFVPCPLDWNLLERTPGRTNPAPASTAAMSSNSFPYNEQSGGGEATELGQEATSTISPSGAFGLFSSDLKKNEDLKQMLES NKDSAKLDAMKRIVGMIAKGKNASELFPAVVKNVASKNIEIKKLVYVYLVRYAEEQQDLALLSISTFQRALKDPNQLIRASALRVLSSIR VPIIVPIMMLAIKEASADLSPYVRKNAAHAIQKLYSLDPEQKEMLIEVIEKLLKDKSTLVAGSVVMAFEEVCPDRIDLIHKNYRKLCNLL VDVEEWGQVVIIHMLTRYARTQFVSPWKEGDELEDNGKNFYESDDDQKEKTDKKKKPYTMDPDHRLLIRNTKPLLQSRNAAVVMAVAQLY WHISPKSEAGIISKSLVRLLRSNREVQYIVLQNIATMSIQRKGMFEPYLKSFYVRSTDPTMIKTLKLEILTNLANEANISTLLREFQTYV KSQDKQFAAATIQTIGRCATNILEVTDTCLNGLVCLLSNRDEIVVAESVVVIKKLLQMQPAQHGEIIKHMAKLLDSITVPVARASILWLI GENCERVPKIAPDVLRKMAKSFTSEDDLVKLQILNLGAKLYLTNSKQTKLLTQYILNLGKYDQNYDIRDRTRFIRQLIVPNVKSGALSKY AKKIFLAQKPAPLLESPFKDRDHFQLGTLSHTLNIKATGYLELSNWPEVAPDPSVRNVEVIELVDSHYCPSCLENMPSAEAKLKKNRCAN CFDCPGCMHTLSTRATSISTQLPDDPAKTTMKKAYYLACGFCRWTSRDVGMADKSVASGGWQEPENPHTQRMNKLIEYYQQLAQKEKVER DRKKLARRRNYMPLAFSDKYGLGTRLQRPRAGASISTLAGLSLKEGEDQKEIKIEPAQAVDEVEPLPEDYYTRPVNLTEVTTLQQRLLQP DFQPVCASQLYPRHKHLLIKRSLRCRKCEHNLSKPEFNPTSIKFKIQLVAVNYIPEVRIMSIPNLRYMKESQVLLTLTNPVENLTHVTLF ECEEGDPDDINSTAKVVVPPKELVLAGKDAAAEYDELAEPQDFQDDPDIIAFRKANKVGIFIKVTPQREEGEVTVCFKMKHDFKNLAAPI -------------------------------------------------------------- >5266_5266_2_AP3B1-DCTN4_AP3B1_chr5_77423854_ENST00000519295_DCTN4_chr5_150136049_ENST00000447998_length(transcript)=6050nt_BP=2093nt GCCTGCGCGCGCTCCTCCGTACGAGAACTAGTTTTGTTCCGTGCCCTCTGGACTGGAACCTTTTGGAGAGAACCCCCGGCAGGACCAACC CCGCACCCGCCAGCACCGCGGCAATGTCCAGCAATAGTTTTCCTTACAATGAGCAGTCCGGAGGAGGGGAGGCGACGGAGCTGGGTCAGG AGGCGACCTCAACCATTTCCCCCTCGGGGGCCTTCGGCCTCTTTAGCAGCGATTTGAAGAAGTGAGGAGAAAGGAATGAAGATCTAAAGC AAATGTTAGAGAGCAACAAAGATTCTGCTAAACTGGATGCTATGAAGCGGATTGTTGGGATGATTGCAAAAGGGAAAAATGCATCTGAAC TGTTTCCTGCTGTTGTGAAGAATGTGGCCAGTAAAAATATTGAGATCAAGAAGTTGGTATATGTTTACCTGGTTCGATATGCTGAAGAAC AGCAGGATCTTGCACTCCTGTCCATAAGCACTTTTCAGCGAGCTCTGAAGGACCCAAACCAACTAATTCGTGCAAGCGCTTTGAGAGTTC TGTCAAGTATTAGAGTGCCAATTATTGTACCTATCATGATGCTTGCTATTAAGGAAGCTTCTGCTGACTTATCACCATATGTTAGGAAGA ATGCAGCCCATGCAATACAAAAATTATACAGCCTTGATCCAGAGCAGAAGGAAATGTTAATTGAAGTAATTGAAAAACTTCTGAAAGATA AAAGCACATTGGTAGCTGGCAGTGTTGTGATGGCTTTTGAAGAAGTATGCCCGGACAGAATAGATCTGATTCATAAAAATTACCGCAAGC TATGTAACTTACTAGTGGATGTTGAAGAGTGGGGGCAGGTTGTCATAATCCACATGCTAACTCGATATGCTCGGACACAGTTTGTCAGCC CTTGGAAAGAGGGTGATGAATTAGAAGACAATGGAAAGAATTTCTACGAATCTGATGATGATCAGAAGGAAAAGACTGACAAAAAGAAGA AGCCGTATACTATGGATCCAGATCATAGACTCTTAATTAGAAATACAAAGCCTTTGCTTCAGAGCAGGAATGCTGCGGTGGTTATGGCAG TTGCTCAGCTGTATTGGCACATATCACCAAAATCTGAAGCTGGCATAATTTCTAAATCACTAGTGCGTTTACTTCGTAGCAATAGGGAGG TGCAGTATATTGTCCTACAAAATATAGCAACTATGTCAATTCAAAGAAAGGGGATGTTTGAACCTTATCTGAAGAGTTTCTATGTTAGGT CAACTGATCCAACTATGATCAAGACACTGAAGCTTGAAATTTTGACAAACTTGGCAAATGAAGCCAACATATCAACTCTTCTTCGAGAAT TTCAGACCTATGTGAAAAGCCAGGATAAACAATTTGCAGCAGCCACTATTCAGACTATAGGCAGATGTGCAACCAACATCTTGGAAGTCA CTGACACGTGCCTCAATGGCTTGGTCTGTCTGCTGTCCAACAGGGATGAAATAGTTGTTGCTGAAAGTGTGGTTGTTATAAAGAAATTAC TGCAAATGCAACCTGCACAACATGGTGAAATTATTAAACATATGGCCAAACTCCTGGACAGTATCACTGTTCCTGTTGCTAGAGCAAGTA TTCTTTGGCTAATTGGAGAAAACTGTGAACGAGTTCCTAAAATTGCCCCTGATGTTTTGAGGAAGATGGCTAAAAGCTTCACTAGTGAAG ATGATCTGGTAAAACTGCAGATATTAAATCTGGGAGCAAAATTGTATTTAACCAACTCCAAACAGACAAAATTGCTTACCCAGTACATAT TAAATCTCGGCAAGTATGATCAAAACTACGACATCAGAGACCGTACAAGATTTATTAGGCAGCTTATTGTTCCGAATGTAAAGAGTGGAG CTTTAAGTAAATATGCCAAAAAAATATTCCTAGCACAAAAGCCTGCACCACTGCTTGAGTCTCCTTTTAAAGATAGAGATCATTTCCAGC TTGGCACCTTATCTCATACTCTCAACATTAAAGCTACTGGGTACCTGGAATTATCTAATTGGCCAGAGGTGGCGCCCGACCCATCAGTTC GAAATGTAGAAGTAATAGAGTTGGTGGACTCCCATTATTGTCCCAGTTGTTTAGAAAATATGCCATCGGCTGAAGCCAAACTAAAAAAGA ATAGATGTGCCAATTGTTTTGACTGTCCTGGCTGCATGCACACCCTCTCTACTCGGGCCACGAGCATCTCCACACAGCTTCCAGATGACC CAGCCAAGACCACCATGAAGAAAGCCTATTACCTGGCATGTGGATTTTGTCGCTGGACGTCTAGAGATGTGGGCATGGCAGACAAATCTG TAGCTAGTGGCGGTTGGCAGGAACCTGAAAATCCTCACACACAACGGATGAACAAATTGATTGAATATTACCAGCAGCTTGCTCAGAAAG AGAAGGTTGAGCGAGATCGCAAGAAACTGGCACGACGTAGAAACTATATGCCTCTGGCTTTTTCGGACAAATATGGTCTTGGAACCAGGC TTCAGCGACCACGAGCTGGTGCATCCATCAGTACCCTTGCCGGACTTTCCCTTAAAGAAGGAGAGGATCAGAAAGAGATAAAGATTGAGC CAGCTCAGGCTGTGGATGAAGTGGAACCTCTACCTGAAGACTATTATACAAGACCAGTAAATTTAACAGAGGTAACAACCCTTCAGCAGC GTCTGTTACAGCCTGACTTCCAGCCAGTCTGTGCTTCACAGCTCTATCCTCGCCACAAACATCTTCTGATCAAACGGTCCCTGCGCTGCC GTAAATGTGAACATAATTTGAGCAAGCCAGAATTTAACCCAACGTCAATCAAATTCAAAATCCAGCTGGTCGCTGTCAATTATATTCCAG AAGTGAGAATCATGTCAATTCCCAACCTTCGCTACATGAAGGAGAGCCAGGTCCTCCTGACTCTTACAAATCCAGTTGAGAACCTCACCC ATGTGACTCTCTTCGAGTGTGAGGAGGGGGACCCTGATGATATCAACAGCACTGCTAAGGTGGTGGTGCCTCCCAAAGAGCTCGTTTTAG CTGGCAAGGATGCAGCAGCAGAGTACGATGAGTTGGCAGAACCTCAAGACTTTCAGGACGATCCTGACATTATAGCCTTCAGAAAGGCCA ACAAAGTGGGTATTTTCATCAAAGTTACACCACAGCGTGAGGAGGGTGAAGTGACCGTGTGCTTCAAGATGAAGCATGATTTTAAAAACC TGGCAGCCCCCATTCGCCCCATTGAAGAAAGTGACCAGGGAACAGAAGTCATCTGGCTCACCCAGCATGTGGAACTTAGCTTGGGCCCAC TTCTTCCTTAAAAGGTTCCACTGGAGGGCAGATCCCAAAGGACAGTATCACCGTAAACCTGCGTTAAAATGTGGAAGCTGCTGCTTCATT AGGCCTTGTTTATAACGATGTACCCATGCACTACGGAATTCTATTGCTAAGAAAGTGGGAGCATAGGCAAGGCATTGGGAACACAGGGTA GCTGCTGTTGCTCTTGCTCTCACCCCTGTTGACACCAGTAAGTCTGTGTCTCCCTCACTGAACCCTGCACGTTGAGTAACAGCAGCATAA TTCCATCCTAGGAAAGGGGATGGGTGTTCCTTGGAATGGCATTGTATTTACCACCTGAGAAACTCTGTACTGTCTCTTGATCTGATCTCA CTAAGGATCACAATGTCACAGATGAAACTTAAATGATAACCCAAAGGTAGACCTGCTGTTAATGATCCAGCATTGGTCACAATGTACCAA CTGCTTTCTGCATTCCGTTAAATATCATCTAACAGTCTAAAACATATCCCTTCATTGCCATAATGGCTGCCATTTTGCCATAGATTTCCA TATAACTGAAAAACTGAATTGTCACTTTATCTTTAGTATCATGATGATTGGAAAAACCTGTGAAGTTGTTAAGGCACTCTCATTTGCCCT CTTTTTCTAAGTGAATACAGGACACGTATTAGTTGTTCTTAATTTTTTTCCCAGTAAAATATGGATCTTTTAAGAAGAATTTGAGAAGCA AACAATTACATGTCATGTCAAGGGGGTAGCAGATTCCATTCGTTTTCAATATTGCCACAATACCCAGGGATTAATGCTGCCACAGGGGGG CAATCTTTATTTGTCTTACTTCCTACCCCTTCCCTGTTCTGCCTCTTTAACTCAGTTAAGTTGTTCTGTTTGGGACCTGGAAAAGAACCC AAAGAAAACCTGAGTGGACAGGTTCATTTCTGGAATGCAGAAAACATTTTAAAGGCTAGATTTTTAGAATATTCTCAACTAGCATTCTTT CCATTGATTTGAAGGGGAAATTAACTATTATAATCTCTTGAATCCAAAACTGGATATTAAGAACTTTCCCCCTTACTAAGTTTAAGACTT TTGTCATGTGGTGAGTCAAATAAGACCATTTTGATTGTAAACCATAAAATAGTTCAGCAAGTAGCCCACAGTTCTGGCCTAACAGCAGAC TTGCTGTTTTCACTTGGTATCCTGGAGTTGGGTTGCTAACCTTAATTTCTATGATGTTTTCTAAAATGAAACTTGATAAAGTAGACCACC AGCTGCACCGTGTTTTCTGTAAAAGTATTGTTAGTAAGTGGCCAAGAGACTTGAGGAAAATACAGATTTTTTGTTTACCTTGGTCTTGTT TTAAGTCTTAAAAAATTAAAGATAACATTATAATGTAGAATACAGATGGGACATAGTCCTTGTAAGCTTCCCTTGAAAATGTTTTAAATA TTTAGGAAGCTTTTAAAAGACACTAAATTGTACTCTAAAAGACACTAAATTGTACTAATTGTACAAAGGTCAAGCCAATTTTATGAAACA GTCCTACAGAGTAATATATGTGATGCAGTGTAAGAAGGAAAATACTCATCTCTAACATTATGGTAATAACATTTAGCCTCTTAGGAGTTG GAGCAGGGGGATGGGTAATTACAGATTTGCAGACTATAGAAAGAGTTTCATTTTTTTGTGACCCCACAGAGTCTCAAATTTTTATTTCAC TACCTGCTAGAGCCTACTGTGAAATCACTGCTCCATATTTGCCAGTGGAGGAAATGGGCATAGAGTAGAGAATAGCTTCATATGTTTACA CGTTTGCATAGACTACACACATGTCATGCGTTTATGGCAGGTAGCTGGTATTTATTCCCCAAAGTAATAATGTTGAAGTATGGGTCTCAT CATTCCCATACACAGAAACACAAAACACTTTGATCATAAACTTTTTTCTTCAGAAGCCAAACTAACTTGCAGAATAATAGAGCCACTGGT TTAATGTTTCCTCAAGATAGGTTTTAGTGTAAGCTAGTATTCTGTGTGTTCGTAGAAATGATTCAATACCTGCAGCTGGTGAATTAGGAA TTGTATTTGTTGCCTTTTTTATATTAGATGAGGTGCAAAAATTTTAATGCTAGTCAGTATGCACCACCACAGGAAAGTTAGATCCCATTA GCACTTGAAACTACAGCTTTGGAAACTTAGGCTAAGTTAATTTGGATTTGTTACTTGATTCACCTACTGACCTTTTCTTTTGTTTGAAGT GCTTATCAGCATAATGAGCTAAGTGTCATGCATATTTGTGAAGAAACACCCTTTTTGGTCCCTTTTGGGACAGAGAGGTACTCCTTGATC TTTATGAATGACAGGTTACTGTTTTGCCTTATTGCTTAACTTAATGTAGTGAAATAAAGCAGACAAAGCTTGAGCGTGTCTTTTGTTTGC TCTCATGTAGATACTAAGTAGCATGGCTCAGAGCCAAAAGACAAGCGTGAAGTTAAGAGAGTTGGCTAAGAGAGTTGGTGGGGCATGCTC CCTTCCATTCCTTAAATGAAGTAATCTAAAATCTCTTAGCAGGTTAGTTCACCATAATATATAAGTAGATGTTGCTTTGAGCTTCTTATA TACATATTCACAGAACCATTATATAAATGTTGTTAGACCTCTACCAGTTTTTATCCTGGGTCATTGCTTCTAAAGATATCCTTTACAATA >5266_5266_2_AP3B1-DCTN4_AP3B1_chr5_77423854_ENST00000519295_DCTN4_chr5_150136049_ENST00000447998_length(amino acids)=1022AA_BP=607 MLESNKDSAKLDAMKRIVGMIAKGKNASELFPAVVKNVASKNIEIKKLVYVYLVRYAEEQQDLALLSISTFQRALKDPNQLIRASALRVL SSIRVPIIVPIMMLAIKEASADLSPYVRKNAAHAIQKLYSLDPEQKEMLIEVIEKLLKDKSTLVAGSVVMAFEEVCPDRIDLIHKNYRKL CNLLVDVEEWGQVVIIHMLTRYARTQFVSPWKEGDELEDNGKNFYESDDDQKEKTDKKKKPYTMDPDHRLLIRNTKPLLQSRNAAVVMAV AQLYWHISPKSEAGIISKSLVRLLRSNREVQYIVLQNIATMSIQRKGMFEPYLKSFYVRSTDPTMIKTLKLEILTNLANEANISTLLREF QTYVKSQDKQFAAATIQTIGRCATNILEVTDTCLNGLVCLLSNRDEIVVAESVVVIKKLLQMQPAQHGEIIKHMAKLLDSITVPVARASI LWLIGENCERVPKIAPDVLRKMAKSFTSEDDLVKLQILNLGAKLYLTNSKQTKLLTQYILNLGKYDQNYDIRDRTRFIRQLIVPNVKSGA LSKYAKKIFLAQKPAPLLESPFKDRDHFQLGTLSHTLNIKATGYLELSNWPEVAPDPSVRNVEVIELVDSHYCPSCLENMPSAEAKLKKN RCANCFDCPGCMHTLSTRATSISTQLPDDPAKTTMKKAYYLACGFCRWTSRDVGMADKSVASGGWQEPENPHTQRMNKLIEYYQQLAQKE KVERDRKKLARRRNYMPLAFSDKYGLGTRLQRPRAGASISTLAGLSLKEGEDQKEIKIEPAQAVDEVEPLPEDYYTRPVNLTEVTTLQQR LLQPDFQPVCASQLYPRHKHLLIKRSLRCRKCEHNLSKPEFNPTSIKFKIQLVAVNYIPEVRIMSIPNLRYMKESQVLLTLTNPVENLTH VTLFECEEGDPDDINSTAKVVVPPKELVLAGKDAAAEYDELAEPQDFQDDPDIIAFRKANKVGIFIKVTPQREEGEVTVCFKMKHDFKNL -------------------------------------------------------------- |
Top |
Fusion Gene PPI Analysis for AP3B1-DCTN4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for AP3B1-DCTN4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for AP3B1-DCTN4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies