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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:AP3B1-IPO11 (FusionGDB2 ID:5267)

Fusion Gene Summary for AP3B1-IPO11

Fusion gene summary

Fusion gene information	Fusion gene name: AP3B1-IPO11
	Fusion gene ID: 5267
		Hgene	Tgene
	Gene symbol	AP3B1	IPO11
	Gene ID	8546	51194
	Gene name	adaptor related protein complex 3 subunit beta 1	importin 11
	Synonyms	ADTB3\|ADTB3A\|HPS\|HPS2\|PE	RanBP11
	Cytomap	5q14.1	5q12.1
	Type of gene	protein-coding	protein-coding
	Description	AP-3 complex subunit beta-1AP-3 complex beta-3A subunitadaptor protein complex AP-3 subunit beta-1adaptor related protein complex 3 beta 1 subunitbeta-3A-adaptinclathrin assembly protein complex 3 beta-1 large chain	importin-11Ran binding protein 11imp11ran-binding protein 11
	Modification date	20200313	20200313
	UniProtAcc	O00203	Q9UI26
	Ensembl transtripts involved in fusion gene	ENST00000255194, ENST00000519295, ENST00000523204,	ENST00000409534, ENST00000512177, ENST00000325324, ENST00000409296,
Fusion gene scores	* DoF score	10 X 12 X 6=720	6 X 6 X 7=252
	# samples	12	7
	** MAII score	log2(12/720*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/252*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: AP3B1 [Title/Abstract] AND IPO11 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	AP3B1(77590276)-IPO11(61762958), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across AP3B1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across IPO11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SKCM	TCGA-D3-A51N-06A	AP3B1	chr5	77590276	-	IPO11	chr5	61762958	+

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Fusion Gene ORF analysis for AP3B1-IPO11

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000255194	ENST00000409534	AP3B1	chr5	77590276	-	IPO11	chr5	61762958	+
5CDS-intron	ENST00000255194	ENST00000512177	AP3B1	chr5	77590276	-	IPO11	chr5	61762958	+
In-frame	ENST00000255194	ENST00000325324	AP3B1	chr5	77590276	-	IPO11	chr5	61762958	+
In-frame	ENST00000255194	ENST00000409296	AP3B1	chr5	77590276	-	IPO11	chr5	61762958	+
intron-3CDS	ENST00000519295	ENST00000325324	AP3B1	chr5	77590276	-	IPO11	chr5	61762958	+
intron-3CDS	ENST00000519295	ENST00000409296	AP3B1	chr5	77590276	-	IPO11	chr5	61762958	+
intron-3CDS	ENST00000523204	ENST00000325324	AP3B1	chr5	77590276	-	IPO11	chr5	61762958	+
intron-3CDS	ENST00000523204	ENST00000409296	AP3B1	chr5	77590276	-	IPO11	chr5	61762958	+
intron-intron	ENST00000519295	ENST00000409534	AP3B1	chr5	77590276	-	IPO11	chr5	61762958	+
intron-intron	ENST00000519295	ENST00000512177	AP3B1	chr5	77590276	-	IPO11	chr5	61762958	+
intron-intron	ENST00000523204	ENST00000409534	AP3B1	chr5	77590276	-	IPO11	chr5	61762958	+
intron-intron	ENST00000523204	ENST00000512177	AP3B1	chr5	77590276	-	IPO11	chr5	61762958	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000255194

AP3B1

chr5

77590276

ENST00000325324

IPO11

chr5

61762958

3975

304

337

2715

792

ENST00000255194

AP3B1

chr5

77590276

ENST00000409296

IPO11

chr5

61762958

3102

304

337

2715

792

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000255194	ENST00000325324	AP3B1	chr5	77590276	-	IPO11	chr5	61762958	+	0.000530878	0.9994691
ENST00000255194	ENST00000409296	AP3B1	chr5	77590276	-	IPO11	chr5	61762958	+	0.000819178	0.99918085

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Fusion Genomic Features for AP3B1-IPO11

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
AP3B1	chr5	77590275	-	IPO11	chr5	61762957	+	4.19E-05	0.99995816
AP3B1	chr5	77590275	-	IPO11	chr5	61762957	+	4.19E-05	0.99995816

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for AP3B1-IPO11

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:77590276/chr5:61762958)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
AP3B1 O00203	IPO11 Q9UI26
FUNCTION: Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. {ECO:0000305\|PubMed:9151686}.	FUNCTION: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBE2E3, and of RPL12 (By similarity). {ECO:0000250, ECO:0000269\|PubMed:11032817}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

IPO11

chr5:77590276

chr5:61762958

ENST00000325324

209_248

172

976.0

Repeat

Note=HEAT 2

Tgene

IPO11

chr5:77590276

chr5:61762958

ENST00000325324

318_356

172

976.0

Repeat

Note=HEAT 3

Tgene

IPO11

chr5:77590276

chr5:61762958

ENST00000325324

422_459

172

976.0

Repeat

Note=HEAT 4

Tgene

IPO11

chr5:77590276

chr5:61762958

ENST00000325324

473_509

172

976.0

Repeat

Note=HEAT 5

Tgene

IPO11

chr5:77590276

chr5:61762958

ENST00000325324

511_548

172

976.0

Repeat

Note=HEAT 6

Tgene

IPO11

chr5:77590276

chr5:61762958

ENST00000325324

555_593

172

976.0

Repeat

Note=HEAT 7

Tgene

IPO11

chr5:77590276

chr5:61762958

ENST00000325324

600_636

172

976.0

Repeat

Note=HEAT 8

Tgene

IPO11

chr5:77590276

chr5:61762958

ENST00000325324

640_677

172

976.0

Repeat

Note=HEAT 9

Tgene

IPO11

chr5:77590276

chr5:61762958

ENST00000325324

683_720

172

976.0

Repeat

Note=HEAT 10

Tgene

IPO11

chr5:77590276

chr5:61762958

ENST00000325324

743_764

172

976.0

Repeat

Note=HEAT 11

Tgene

IPO11

chr5:77590276

chr5:61762958

ENST00000325324

765_804

172

976.0

Repeat

Note=HEAT 12

Tgene

IPO11

chr5:77590276

chr5:61762958

ENST00000325324

819_849

172

976.0

Repeat

Note=HEAT 13

Tgene

IPO11

chr5:77590276

chr5:61762958

ENST00000325324

850_887

172

976.0

Repeat

Note=HEAT 14

Tgene

IPO11

chr5:77590276

chr5:61762958

ENST00000325324

957_974

172

976.0

Repeat

Note=HEAT 15

Tgene

IPO11

chr5:77590276

chr5:61762958

ENST00000409296

209_248

212

1016.0

Repeat

Note=HEAT 2

Tgene

IPO11

chr5:77590276

chr5:61762958

ENST00000409296

318_356

212

1016.0

Repeat

Note=HEAT 3

Tgene

IPO11

chr5:77590276

chr5:61762958

ENST00000409296

422_459

212

1016.0

Repeat

Note=HEAT 4

Tgene

IPO11

chr5:77590276

chr5:61762958

ENST00000409296

473_509

212

1016.0

Repeat

Note=HEAT 5

Tgene

IPO11

chr5:77590276

chr5:61762958

ENST00000409296

511_548

212

1016.0

Repeat

Note=HEAT 6

Tgene

IPO11

chr5:77590276

chr5:61762958

ENST00000409296

555_593

212

1016.0

Repeat

Note=HEAT 7

Tgene

IPO11

chr5:77590276

chr5:61762958

ENST00000409296

600_636

212

1016.0

Repeat

Note=HEAT 8

Tgene

IPO11

chr5:77590276

chr5:61762958

ENST00000409296

640_677

212

1016.0

Repeat

Note=HEAT 9

Tgene

IPO11

chr5:77590276

chr5:61762958

ENST00000409296

683_720

212

1016.0

Repeat

Note=HEAT 10

Tgene

IPO11

chr5:77590276

chr5:61762958

ENST00000409296

743_764

212

1016.0

Repeat

Note=HEAT 11

Tgene

IPO11

chr5:77590276

chr5:61762958

ENST00000409296

765_804

212

1016.0

Repeat

Note=HEAT 12

Tgene

IPO11

chr5:77590276

chr5:61762958

ENST00000409296

819_849

212

1016.0

Repeat

Note=HEAT 13

Tgene

IPO11

chr5:77590276

chr5:61762958

ENST00000409296

850_887

212

1016.0

Repeat

Note=HEAT 14

Tgene

IPO11

chr5:77590276

chr5:61762958

ENST00000409296

957_974

212

1016.0

Repeat

Note=HEAT 15

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

AP3B1

chr5:77590276

chr5:61762958

ENST00000255194

677_802

1095.0

Compositional bias

Note=Glu/Ser-rich

Tgene

IPO11

chr5:77590276

chr5:61762958

ENST00000325324

28_100

172

976.0

Domain

Importin N-terminal

Tgene

IPO11

chr5:77590276

chr5:61762958

ENST00000409296

28_100

212

1016.0

Domain

Importin N-terminal

Tgene

IPO11

chr5:77590276

chr5:61762958

ENST00000325324

123_160

172

976.0

Repeat

Note=HEAT 1

Tgene

IPO11

chr5:77590276

chr5:61762958

ENST00000409296

123_160

212

1016.0

Repeat

Note=HEAT 1

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Fusion Gene Sequence for AP3B1-IPO11

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>5267_5267_1_AP3B1-IPO11_AP3B1_chr5_77590276_ENST00000255194_IPO11_chr5_61762958_ENST00000325324_length(transcript)=3975nt_BP=304nt
ACTGCGCATGCGCAGGGGGTGGACTGCCAGGTCGGCTCAGGGAGCCGTGACGAGTCCGGAAGCGCCTGCGCGCGCTCCTCCGTACGAGAA
CTAGTTTTGTTCCGTGCCCTCTGGACTGGAACCTTTTGGAGAGAACCCCCGGCAGGACCAACCCCGCACCCGCCAGCACCGCGGCAATGT
CCAGCAATAGTTTTCCTTACAATGAGCAGTCCGGAGGAGGGGAGGCGACGGAGCTGGGTCAGGAGGCGACCTCAACCATTTCCCCCTCGG
GGGCCTTCGGCCTCTTTAGCAGCGATTTGAAGAATTAGCTTCTGGAATTTATAATTTTGCCTGCTCTCTGTGGAATCACCACACAGACAC
ATTCCTGCAAGAAGTTTCTTCTGGCAATGAAGCTGCAATTTTGAGTTCACTAGAACGAACACTGCTATCATTGAAAGTGCTGCGTAAGTT
AACTGTTAATGGATTTGTGGAACCTCATAAGAATATGGAGGTGATGGGTTTTTTACATGGAATATTTGAACGTCTAAAACAGTTTCTGGA
ATGCAGTAGAAGTATAGGTACAGATAATGTGTGTAGAGATAGACTGGAAAAGACCATCATTCTTTTTACTAAAGTGCTTTTGGACTTCTT
GGATCAGCATCCTTTTTCATTTACTCCTCTAATTCAGAGATCACTGGAATTTTCTGTAAGCTATGTTTTTACAGAAGTTGGTGAAGGCGT
TACATTTGAACGATTCATTGTCCAATGTATGAATCTTATTAAGATGATTGTCAAAAATTATGCTTATAAGCCATCCAAAAATTTTGAAGA
TAGCAGCCCTGAAACTCTTGAAGCCCATAAGATTAAGATGGCATTCTTCACATATCCTACTTTGACAGAGATATGTAGAAGATTAGTCTC
TCATTATTTCCTATTAACTGAAGAAGAACTGACAATGTGGGAAGAAGACCCAGAAGGCTTTACAGTGGAAGAAACAGGAGGAGATTCTTG
GAAATATAGTTTGAGGCCATGCACTGAAGTATTATTTATAGATATATTCCATGAATATAATCAGACTCTTACTCCTGTACTTCTAGAAAT
GATGCAAACACTTCAAGGACCCACAAATGTGGAAGATATGAATGCACTGTTAATCAAAGATGCTGTGTATAATGCTGTTGGATTAGCTGC
TTATGAGCTCTTTGACAGTGTTGATTTTGATCAGTGGTTTAAAAACCAGCTTCTTCCAGAATTACAAGTCATTCACAATAGGTATAAGCC
ATTGCGACGCAGGGTGATTTGGCTCATCGGTCAGTGGATTTCTGTGAAATTCAAGTCTGACTTAAGACCCATGCTTTATGAAGCAATCTG
TAACTTGCTTCAAGATCAAGATTTAGTGGTCCGTATTGAAACAGCTACAACTTTGAAGTTAACTGTTGATGATTTTGAATTTAGAACAGA
TCAGTTTCTACCGTATTTGGAAACCATGTTCACACTACTTTTTCAGTTACTGCAGCAAGTTACAGAATGTGACACAAAGATGCATGTTTT
GCATGTCCTTTCTTGTGTGATCGAAAGAGTCAACATGCAGATACGACCATATGTGGGATGTTTGGTACAATATTTGCCCCTCCTTTGGAA
GCAGAGTGAAGAACACAATATGTTGAGATGTGCTATTTTGACAACACTTATTCATCTTGTTCAGGGATTAGGAGCAGACAGCAAGAACCT
GTACCCTTTCCTGCTCCCAGTTATTCAACTGAGTACAGATGTTTCACAGCCTCCACATGTTTATCTTCTGGAAGATGGTTTAGAATTATG
GTTAGTAACTTTGGAAAACAGTCCATGTATTACACCAGAGTTGCTTCGTATATTTCAGAATATGTCACCACTTCTTGAACTAAGTTCAGA
AAATCTTAGAACTTGCTTTAAGATCATCAATGGTTATATCTTTTTATCATCAACAGAATTTTTACAGACATACGCAGTAGGTCTATGCCA
GTCCTTTTGTGAACTTTTAAAGGAAATTACTACAGAAGGTCAAGTTCAGGTGCTCAAGGTTGTGGAAAATGCCCTTAAAGTGAACCCAAT
ACTAGGTCCACAAATGTTTCAACCGATTTTACCCTATGTTTTCAAGGGTATTATAGAAGGGGAGAGGTATCCTGTAGTGATGTCCACGTA
TCTTGGAGTTATGGGTCGAGTTCTACTACAAAACACTAGTTTTTTTTCTTCACTACTTAATGAGATGGCCCATAAATTTAATCAGGAGAT
GGACCAGCTTTTGGGAAATATGATTGAAATGTGGGTTGATCGAATGGACAACATTACCCAGCCTGAAAGAAGAAAACTTTCAGCTTTGGC
TTTGCTCTCTCTTCTGCCATCTGATAATAGTGTTATCCAAGATAAATTCTGTGGGATTATAAACATTTCAGTAGAAGGCCTGCATGATGT
CATGACGGAAGATCCTGAAACAGGAACTTATAAAGACTGTATGTTGATGTCTCATCTTGAGGAACCAAAAGTAACAGAAGATGAAGAACC
ACCCACAGAACAAGATAAGAGGAAAAAGATGCTGGCCCTGAAGGACCCTGTTCATACAGTGTCACTGCAGCAGTTCATCTACGAGAAGCT
CAAGGCACAGCAGGAGATGCTAGGAGAACAAGGTTTCCAGTCCCTCATGGAAACAGTGGATACGGAGATTGTCACCCAGCTACAGGAGTT
TTTGCAAGGATTCTAAGAGCACATGACATGTGGCTGCCTCCCCTTTCAGAAACAAGCTGAGTAACCCAGCCTGCCGTTTGTATGTGAGAG
CCTGCTGAGATGAAGAAATCACTTCATGAAAATAAGCAAAGACCACACATTTTTTACTACAAAATGTAAAGGATAAATGTAAATCCTGCA
TAACTAAAATCACAAACCTATTCCTCAAAAGAATTTAATTTTATATTTATGAGGGGGCCCTTCACTAAAAAGTACATGTAAAAGTACATT
TGATGACAATAGCTGCTTAGTTTCCTGTTAAGAGAAGAAACTTTATCTTTTAATTATGTGCTCTTAATATTTGAAGATGAGAGTTAATAC
CTGAGATGTTTTTCTGCAACCAAAATTCATTAAATTTGGCTGCCTTATCCTTTTTTTAAGCTAATGAAACTACAGGTTTGAAAAATGACA
AAGCTGTTCAGATGATGCTATTAAAGAAATGTGTGTACTAAGCAAAAATATATAAATAGTGACAAATACACATTACCAAGCTTATCTTGC
AAGGGAGTTATTTTCATCTAACATAGAAAGTGTGTTTTATCAGACAAATGCTTTTATTTTCATTCTAATAATTTGATACAGAAATTAGTA
AAGGCATTTTTTTCTTTTTTTTTCCAGTAAATACATTGGGTCTATAAATGTGCATTTGTAAGGGCCACAAAAGTGAACGTGTGGTACTGT
AGTACCACGTGGGAGACCTCTGGTTATGGTTTAGTCCTAGTTCCTTTGTTACTCCTGTGAGCACCGAGAAGAACTGGGCGACTCCCAGTC
CCACCTGTGCTGTGACAGTCCCACGTGGCTATGACAGACTGTTTAGTACTTACCCTTCTCAGGTTCCTCAGTGCAGGGGTGCATCAGGGC
CTCAATAATAGGGGTATACCTGGGAGGATCCAGCAGTAATCCCCAGGGTACTAGGATTACTAGTACTCTGATGGAACTAGTCTTCCTTCC
TTATTCCTCGAACATGCAGTACATAAAAAGGGGAAAAGGAGAAAAAAAAAGCCTTACTTTGTTTTACTTGCCATTTATTGTAAGGAAACT
TTAAAGCATTTTTTAGGAAATACTCAAAAGCAAGGTTGGAAAATGTTTTATCTTTCTATAGAAAGTTGGGTACAGTATGTAACTGCGGGA
AACCCACTGCCCCTTTGTAAGCTGTGGAACCCAAACTGTATGGGGATATTTGATGTTTTCAGAAAGAGGAAGAAAATATGGTCCAAATTA

>5267_5267_1_AP3B1-IPO11_AP3B1_chr5_77590276_ENST00000255194_IPO11_chr5_61762958_ENST00000325324_length(amino acids)=792AA_BP=
MWNHHTDTFLQEVSSGNEAAILSSLERTLLSLKVLRKLTVNGFVEPHKNMEVMGFLHGIFERLKQFLECSRSIGTDNVCRDRLEKTIILF
TKVLLDFLDQHPFSFTPLIQRSLEFSVSYVFTEVGEGVTFERFIVQCMNLIKMIVKNYAYKPSKNFEDSSPETLEAHKIKMAFFTYPTLT
EICRRLVSHYFLLTEEELTMWEEDPEGFTVEETGGDSWKYSLRPCTEVLFIDIFHEYNQTLTPVLLEMMQTLQGPTNVEDMNALLIKDAV
YNAVGLAAYELFDSVDFDQWFKNQLLPELQVIHNRYKPLRRRVIWLIGQWISVKFKSDLRPMLYEAICNLLQDQDLVVRIETATTLKLTV
DDFEFRTDQFLPYLETMFTLLFQLLQQVTECDTKMHVLHVLSCVIERVNMQIRPYVGCLVQYLPLLWKQSEEHNMLRCAILTTLIHLVQG
LGADSKNLYPFLLPVIQLSTDVSQPPHVYLLEDGLELWLVTLENSPCITPELLRIFQNMSPLLELSSENLRTCFKIINGYIFLSSTEFLQ
TYAVGLCQSFCELLKEITTEGQVQVLKVVENALKVNPILGPQMFQPILPYVFKGIIEGERYPVVMSTYLGVMGRVLLQNTSFFSSLLNEM
AHKFNQEMDQLLGNMIEMWVDRMDNITQPERRKLSALALLSLLPSDNSVIQDKFCGIINISVEGLHDVMTEDPETGTYKDCMLMSHLEEP

--------------------------------------------------------------
>5267_5267_2_AP3B1-IPO11_AP3B1_chr5_77590276_ENST00000255194_IPO11_chr5_61762958_ENST00000409296_length(transcript)=3102nt_BP=304nt
ACTGCGCATGCGCAGGGGGTGGACTGCCAGGTCGGCTCAGGGAGCCGTGACGAGTCCGGAAGCGCCTGCGCGCGCTCCTCCGTACGAGAA
CTAGTTTTGTTCCGTGCCCTCTGGACTGGAACCTTTTGGAGAGAACCCCCGGCAGGACCAACCCCGCACCCGCCAGCACCGCGGCAATGT
CCAGCAATAGTTTTCCTTACAATGAGCAGTCCGGAGGAGGGGAGGCGACGGAGCTGGGTCAGGAGGCGACCTCAACCATTTCCCCCTCGG
GGGCCTTCGGCCTCTTTAGCAGCGATTTGAAGAATTAGCTTCTGGAATTTATAATTTTGCCTGCTCTCTGTGGAATCACCACACAGACAC
ATTCCTGCAAGAAGTTTCTTCTGGCAATGAAGCTGCAATTTTGAGTTCACTAGAACGAACACTGCTATCATTGAAAGTGCTGCGTAAGTT
AACTGTTAATGGATTTGTGGAACCTCATAAGAATATGGAGGTGATGGGTTTTTTACATGGAATATTTGAACGTCTAAAACAGTTTCTGGA
ATGCAGTAGAAGTATAGGTACAGATAATGTGTGTAGAGATAGACTGGAAAAGACCATCATTCTTTTTACTAAAGTGCTTTTGGACTTCTT
GGATCAGCATCCTTTTTCATTTACTCCTCTAATTCAGAGATCACTGGAATTTTCTGTAAGCTATGTTTTTACAGAAGTTGGTGAAGGCGT
TACATTTGAACGATTCATTGTCCAATGTATGAATCTTATTAAGATGATTGTCAAAAATTATGCTTATAAGCCATCCAAAAATTTTGAAGA
TAGCAGCCCTGAAACTCTTGAAGCCCATAAGATTAAGATGGCATTCTTCACATATCCTACTTTGACAGAGATATGTAGAAGATTAGTCTC
TCATTATTTCCTATTAACTGAAGAAGAACTGACAATGTGGGAAGAAGACCCAGAAGGCTTTACAGTGGAAGAAACAGGAGGAGATTCTTG
GAAATATAGTTTGAGGCCATGCACTGAAGTATTATTTATAGATATATTCCATGAATATAATCAGACTCTTACTCCTGTACTTCTAGAAAT
GATGCAAACACTTCAAGGACCCACAAATGTGGAAGATATGAATGCACTGTTAATCAAAGATGCTGTGTATAATGCTGTTGGATTAGCTGC
TTATGAGCTCTTTGACAGTGTTGATTTTGATCAGTGGTTTAAAAACCAGCTTCTTCCAGAATTACAAGTCATTCACAATAGGTATAAGCC
ATTGCGACGCAGGGTGATTTGGCTCATCGGTCAGTGGATTTCTGTGAAATTCAAGTCTGACTTAAGACCCATGCTTTATGAAGCAATCTG
TAACTTGCTTCAAGATCAAGATTTAGTGGTCCGTATTGAAACAGCTACAACTTTGAAGTTAACTGTTGATGATTTTGAATTTAGAACAGA
TCAGTTTCTACCGTATTTGGAAACCATGTTCACACTACTTTTTCAGTTACTGCAGCAAGTTACAGAATGTGACACAAAGATGCATGTTTT
GCATGTCCTTTCTTGTGTGATCGAAAGAGTCAACATGCAGATACGACCATATGTGGGATGTTTGGTACAATATTTGCCCCTCCTTTGGAA
GCAGAGTGAAGAACACAATATGTTGAGATGTGCTATTTTGACAACACTTATTCATCTTGTTCAGGGATTAGGAGCAGACAGCAAGAACCT
GTACCCTTTCCTGCTCCCAGTTATTCAACTGAGTACAGATGTTTCACAGCCTCCACATGTTTATCTTCTGGAAGATGGTTTAGAATTATG
GTTAGTAACTTTGGAAAACAGTCCATGTATTACACCAGAGTTGCTTCGTATATTTCAGAATATGTCACCACTTCTTGAACTAAGTTCAGA
AAATCTTAGAACTTGCTTTAAGATCATCAATGGTTATATCTTTTTATCATCAACAGAATTTTTACAGACATACGCAGTAGGTCTATGCCA
GTCCTTTTGTGAACTTTTAAAGGAAATTACTACAGAAGGTCAAGTTCAGGTGCTCAAGGTTGTGGAAAATGCCCTTAAAGTGAACCCAAT
ACTAGGTCCACAAATGTTTCAACCGATTTTACCCTATGTTTTCAAGGGTATTATAGAAGGGGAGAGGTATCCTGTAGTGATGTCCACGTA
TCTTGGAGTTATGGGTCGAGTTCTACTACAAAACACTAGTTTTTTTTCTTCACTACTTAATGAGATGGCCCATAAATTTAATCAGGAGAT
GGACCAGCTTTTGGGAAATATGATTGAAATGTGGGTTGATCGAATGGACAACATTACCCAGCCTGAAAGAAGAAAACTTTCAGCTTTGGC
TTTGCTCTCTCTTCTGCCATCTGATAATAGTGTTATCCAAGATAAATTCTGTGGGATTATAAACATTTCAGTAGAAGGCCTGCATGATGT
CATGACGGAAGATCCTGAAACAGGAACTTATAAAGACTGTATGTTGATGTCTCATCTTGAGGAACCAAAAGTAACAGAAGATGAAGAACC
ACCCACAGAACAAGATAAGAGGAAAAAGATGCTGGCCCTGAAGGACCCTGTTCATACAGTGTCACTGCAGCAGTTCATCTACGAGAAGCT
CAAGGCACAGCAGGAGATGCTAGGAGAACAAGGTTTCCAGTCCCTCATGGAAACAGTGGATACGGAGATTGTCACCCAGCTACAGGAGTT
TTTGCAAGGATTCTAAGAGCACATGACATGTGGCTGCCTCCCCTTTCAGAAACAAGCTGAGTAACCCAGCCTGCCGTTTGTATGTGAGAG
CCTGCTGAGATGAAGAAATCACTTCATGAAAATAAGCAAAGACCACACATTTTTTACTACAAAATGTAAAGGATAAATGTAAATCCTGCA
TAACTAAAATCACAAACCTATTCCTCAAAAGAATTTAATTTTATATTTATGAGGGGGCCCTTCACTAAAAAGTACATGTAAAAGTACATT
TGATGACAATAGCTGCTTAGTTTCCTGTTAAGAGAAGAAACTTTATCTTTTAATTATGTGCTCTTAATATTTGAAGATGAGAGTTAATAC

>5267_5267_2_AP3B1-IPO11_AP3B1_chr5_77590276_ENST00000255194_IPO11_chr5_61762958_ENST00000409296_length(amino acids)=792AA_BP=
MWNHHTDTFLQEVSSGNEAAILSSLERTLLSLKVLRKLTVNGFVEPHKNMEVMGFLHGIFERLKQFLECSRSIGTDNVCRDRLEKTIILF
TKVLLDFLDQHPFSFTPLIQRSLEFSVSYVFTEVGEGVTFERFIVQCMNLIKMIVKNYAYKPSKNFEDSSPETLEAHKIKMAFFTYPTLT
EICRRLVSHYFLLTEEELTMWEEDPEGFTVEETGGDSWKYSLRPCTEVLFIDIFHEYNQTLTPVLLEMMQTLQGPTNVEDMNALLIKDAV
YNAVGLAAYELFDSVDFDQWFKNQLLPELQVIHNRYKPLRRRVIWLIGQWISVKFKSDLRPMLYEAICNLLQDQDLVVRIETATTLKLTV
DDFEFRTDQFLPYLETMFTLLFQLLQQVTECDTKMHVLHVLSCVIERVNMQIRPYVGCLVQYLPLLWKQSEEHNMLRCAILTTLIHLVQG
LGADSKNLYPFLLPVIQLSTDVSQPPHVYLLEDGLELWLVTLENSPCITPELLRIFQNMSPLLELSSENLRTCFKIINGYIFLSSTEFLQ
TYAVGLCQSFCELLKEITTEGQVQVLKVVENALKVNPILGPQMFQPILPYVFKGIIEGERYPVVMSTYLGVMGRVLLQNTSFFSSLLNEM
AHKFNQEMDQLLGNMIEMWVDRMDNITQPERRKLSALALLSLLPSDNSVIQDKFCGIINISVEGLHDVMTEDPETGTYKDCMLMSHLEEP

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Fusion Gene PPI Analysis for AP3B1-IPO11

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for AP3B1-IPO11

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for AP3B1-IPO11

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source