Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:AP3B1-MRPS36 (FusionGDB2 ID:5269)

Fusion Gene Summary for AP3B1-MRPS36

Fusion gene summary

Fusion gene information	Fusion gene name: AP3B1-MRPS36
	Fusion gene ID: 5269
		Hgene	Tgene
	Gene symbol	AP3B1	MRPS36
	Gene ID	8546	92259
	Gene name	adaptor related protein complex 3 subunit beta 1	mitochondrial ribosomal protein S36
	Synonyms	ADTB3\|ADTB3A\|HPS\|HPS2\|PE	DC47\|MRP-S36
	Cytomap	5q14.1	5q13.2
	Type of gene	protein-coding	protein-coding
	Description	AP-3 complex subunit beta-1AP-3 complex beta-3A subunitadaptor protein complex AP-3 subunit beta-1adaptor related protein complex 3 beta 1 subunitbeta-3A-adaptinclathrin assembly protein complex 3 beta-1 large chain	28S ribosomal protein S36, mitochondrialS36mt
	Modification date	20200313	20200313
	UniProtAcc	O00203	P82909
	Ensembl transtripts involved in fusion gene	ENST00000255194, ENST00000519295, ENST00000523204,	ENST00000512880, ENST00000602380, ENST00000507022, ENST00000256441,
Fusion gene scores	* DoF score	10 X 12 X 6=720	2 X 2 X 2=8
	# samples	12	2
	** MAII score	log2(12/720*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context	PubMed: AP3B1 [Title/Abstract] AND MRPS36 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	AP3B1(77385216)-MRPS36(68522164), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across AP3B1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MRPS36 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	61N	AP3B1	chr5	77385216	-	MRPS36	chr5	68522164	+

Top

Fusion Gene ORF analysis for AP3B1-MRPS36

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000255194	ENST00000512880	AP3B1	chr5	77385216	-	MRPS36	chr5	68522164	+
5CDS-5UTR	ENST00000255194	ENST00000602380	AP3B1	chr5	77385216	-	MRPS36	chr5	68522164	+
5CDS-5UTR	ENST00000519295	ENST00000512880	AP3B1	chr5	77385216	-	MRPS36	chr5	68522164	+
5CDS-5UTR	ENST00000519295	ENST00000602380	AP3B1	chr5	77385216	-	MRPS36	chr5	68522164	+
5CDS-intron	ENST00000255194	ENST00000507022	AP3B1	chr5	77385216	-	MRPS36	chr5	68522164	+
5CDS-intron	ENST00000519295	ENST00000507022	AP3B1	chr5	77385216	-	MRPS36	chr5	68522164	+
In-frame	ENST00000255194	ENST00000256441	AP3B1	chr5	77385216	-	MRPS36	chr5	68522164	+
In-frame	ENST00000519295	ENST00000256441	AP3B1	chr5	77385216	-	MRPS36	chr5	68522164	+
intron-3CDS	ENST00000523204	ENST00000256441	AP3B1	chr5	77385216	-	MRPS36	chr5	68522164	+
intron-5UTR	ENST00000523204	ENST00000512880	AP3B1	chr5	77385216	-	MRPS36	chr5	68522164	+
intron-5UTR	ENST00000523204	ENST00000602380	AP3B1	chr5	77385216	-	MRPS36	chr5	68522164	+
intron-intron	ENST00000523204	ENST00000507022	AP3B1	chr5	77385216	-	MRPS36	chr5	68522164	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000255194

AP3B1

chr5

77385216

ENST00000256441

MRPS36

chr5

68522164

3927

2753

3022

985

ENST00000519295

AP3B1

chr5

77385216

ENST00000256441

MRPS36

chr5

68522164

3876

2702

272

2971

899

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000255194	ENST00000256441	AP3B1	chr5	77385216	-	MRPS36	chr5	68522164	+	0.000529437	0.99947053
ENST00000519295	ENST00000256441	AP3B1	chr5	77385216	-	MRPS36	chr5	68522164	+	0.000500696	0.9994993

Top

Fusion Genomic Features for AP3B1-MRPS36

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
AP3B1	chr5	77385216	-	MRPS36	chr5	68522168	+	0.000117975	0.999882
AP3B1	chr5	77385216	-	MRPS36	chr5	68522168	+	0.000117975	0.999882

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for AP3B1-MRPS36

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:77385216/chr5:68522164)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
AP3B1 O00203	MRPS36 P82909
FUNCTION: Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. {ECO:0000305\|PubMed:9151686}.	FUNCTION: May be necessary to recruit DLD/E3 to the mitochondrial 2-oxoglutarate dehydrogenase complex (OGDC) core composed of OGDH/E1 and DLST/E2, hence stabilizes the complex. {ECO:0000250\|UniProtKB:Q9CQX8}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

AP3B1

chr5:77385216

chr5:68522164

ENST00000255194

677_802

859

1095.0

Compositional bias

Note=Glu/Ser-rich

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

Fusion Gene Sequence for AP3B1-MRPS36

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>5269_5269_1_AP3B1-MRPS36_AP3B1_chr5_77385216_ENST00000255194_MRPS36_chr5_68522164_ENST00000256441_length(transcript)=3927nt_BP=2753nt
ACTGCGCATGCGCAGGGGGTGGACTGCCAGGTCGGCTCAGGGAGCCGTGACGAGTCCGGAAGCGCCTGCGCGCGCTCCTCCGTACGAGAA
CTAGTTTTGTTCCGTGCCCTCTGGACTGGAACCTTTTGGAGAGAACCCCCGGCAGGACCAACCCCGCACCCGCCAGCACCGCGGCAATGT
CCAGCAATAGTTTTCCTTACAATGAGCAGTCCGGAGGAGGGGAGGCGACGGAGCTGGGTCAGGAGGCGACCTCAACCATTTCCCCCTCGG
GGGCCTTCGGCCTCTTTAGCAGCGATTTGAAGAAGAATGAAGATCTAAAGCAAATGTTAGAGAGCAACAAAGATTCTGCTAAACTGGATG
CTATGAAGCGGATTGTTGGGATGATTGCAAAAGGGAAAAATGCATCTGAACTGTTTCCTGCTGTTGTGAAGAATGTGGCCAGTAAAAATA
TTGAGATCAAGAAGTTGGTATATGTTTACCTGGTTCGATATGCTGAAGAACAGCAGGATCTTGCACTCCTGTCCATAAGCACTTTTCAGC
GAGCTCTGAAGGACCCAAACCAACTAATTCGTGCAAGCGCTTTGAGAGTTCTGTCAAGTATTAGAGTGCCAATTATTGTACCTATCATGA
TGCTTGCTATTAAGGAAGCTTCTGCTGACTTATCACCATATGTTAGGAAGAATGCAGCCCATGCAATACAAAAATTATACAGCCTTGATC
CAGAGCAGAAGGAAATGTTAATTGAAGTAATTGAAAAACTTCTGAAAGATAAAAGCACATTGGTAGCTGGCAGTGTTGTGATGGCTTTTG
AAGAAGTATGCCCGGACAGAATAGATCTGATTCATAAAAATTACCGCAAGCTATGTAACTTACTAGTGGATGTTGAAGAGTGGGGGCAGG
TTGTCATAATCCACATGCTAACTCGATATGCTCGGACACAGTTTGTCAGCCCTTGGAAAGAGGGTGATGAATTAGAAGACAATGGAAAGA
ATTTCTACGAATCTGATGATGATCAGAAGGAAAAGACTGACAAAAAGAAGAAGCCGTATACTATGGATCCAGATCATAGACTCTTAATTA
GAAATACAAAGCCTTTGCTTCAGAGCAGGAATGCTGCGGTGGTTATGGCAGTTGCTCAGCTGTATTGGCACATATCACCAAAATCTGAAG
CTGGCATAATTTCTAAATCACTAGTGCGTTTACTTCGTAGCAATAGGGAGGTGCAGTATATTGTCCTACAAAATATAGCAACTATGTCAA
TTCAAAGAAAGGGGATGTTTGAACCTTATCTGAAGAGTTTCTATGTTAGGTCAACTGATCCAACTATGATCAAGACACTGAAGCTTGAAA
TTTTGACAAACTTGGCAAATGAAGCCAACATATCAACTCTTCTTCGAGAATTTCAGACCTATGTGAAAAGCCAGGATAAACAATTTGCAG
CAGCCACTATTCAGACTATAGGCAGATGTGCAACCAACATCTTGGAAGTCACTGACACGTGCCTCAATGGCTTGGTCTGTCTGCTGTCCA
ACAGGGATGAAATAGTTGTTGCTGAAAGTGTGGTTGTTATAAAGAAATTACTGCAAATGCAACCTGCACAACATGGTGAAATTATTAAAC
ATATGGCCAAACTCCTGGACAGTATCACTGTTCCTGTTGCTAGAGCAAGTATTCTTTGGCTAATTGGAGAAAACTGTGAACGAGTTCCTA
AAATTGCCCCTGATGTTTTGAGGAAGATGGCTAAAAGCTTCACTAGTGAAGATGATCTGGTAAAACTGCAGATATTAAATCTGGGAGCAA
AATTGTATTTAACCAACTCCAAACAGACAAAATTGCTTACCCAGTACATATTAAATCTCGGCAAGTATGATCAAAACTACGACATCAGAG
ACCGTACAAGATTTATTAGGCAGCTTATTGTTCCGAATGTAAAGAGTGGAGCTTTAAGTAAATATGCCAAAAAAATATTCCTAGCACAAA
AGCCTGCACCACTGCTTGAGTCTCCTTTTAAAGATAGAGATCATTTCCAGCTTGGCACCTTATCTCATACTCTCAACATTAAAGCTACTG
GGTACCTGGAATTATCTAATTGGCCAGAGGTGGCGCCCGACCCATCAGTTCGAAATGTAGAAGTAATAGAGTTGGCAAAAGAATGGACCC
CAGCAGGAAAAGCAAAGCAAGAGAATTCTGCTAAGAAGTTTTATTCTGAATCTGAGGAAGAGGAGGACTCTTCTGATAGTAGCAGTGACA
GTGAGAGTGAATCTGGAAGTGAAAGTGGAGAACAAGGCGAAAGTGGGGAGGAAGGAGACAGCAATGAGGACAGCAGTGAGGACTCCTCCA
GTGAGCAGGACAGTGAGAGTGGACGGGAGTCAGGCCTAGAAAACAAAAGAACAGCCAAGAGGAACTCAAAAGCCAAAGGAAAAAGTGATT
CTGAAGATGGGGAGAAGGAAAATGAAAAATCTAAAACTTCAGATTCTTCAAATGACGAATCTAGTTCAATAGAAGACAGTTCTTCCGATT
CTGAATCAGAGTCAGAACCTGAAAGTGAATCTGAATCCAGAAGAGTCACTAAGGAGAAAGAAAAGAAAACAAAGCAAGATAGAACTCCTC
TTACCAAAGATGTTTCACTTCTAGATCTGGATGATTTTAACCCAGTATCCACTCCAGTTGCACTTCCCACACCAGCTCTTTCTCCAAGTT
TGATGGCTGATCTTGAAGGTTTACACTTGTCAACTTCCTCTTCAGTCATCAGTGTAGTCAAACCACACACTCCATTAATAAGGTTTCCTG
ACAGAAGAGACAATCCTAAACCCAATGTATCAGAAGCTTTGAGATCAGCAGGGCTACCATCTCACTCTTCTGTAATTTCACAACATTCTA
AAGGAAGTAAATCACCAGATTTGCTGATGTATCAGGGTCCACCAGACACTGCAGAAATAATAAAAACATTACCTCAGAAATACAGAAGGA
AACTTGTGTCTCAAGAAGAAATGGAATTTATCCAACGTGGAGGTCCTGAATAACCATGGTGGCTGCTGTTTGTCATCAGACAATAGAATT
GTCTTTACAATAAAGGACTTCCAAAATGACAGATGAGAAACTGTATATTAAACACCTTTAATAAATATTATGAAAAAAATGAAATATAGA
AAATTTAGATGGACACTTGTATTTCCTAATTTATGTATCTTGGTCAGCTTCTCCACAAGCTTACCTAATTGTTTATATACTTTATACTTA
TTAAAGTATACATTTTTAAATGTTAGCCTATTAATTTACTCTTGATTATCAAACATTACCAGTGTTGAACTATTAAAAGCACACAATGTG
TAGTAAACTATCATAGGATTCCCATAATTTCACTTTACTTTCTGTTTAGGCATGGAAAAATTTATCAGTCAGAATTGCTGTTTTAGGGAC
ATGATTTTCCTGAAATTGGGTGAGGATCAGTGAAATAATTACTCTATTACTTGTTCTTAATTCTCTGTTCTCTAATGTTTTTTCATTCAC
AAGTTTACTGGAGTATAACTGGCTTAGTAAGTATATCCTACTCTGAATGATAAAAATATAGTCAAGCTAAAATAGGTGACTATACTATTA
AGATAGAGATCATACAAAAGATTCCAAAGAAAGTCAAAAAGTGTAAAATGGAAAATAAGAGATCAAAATGAATATAGCATAGGAATAAAG
ATTTCACTAGAAATTGCAATTTATTATGTTTTGGAGGTTGTAAGGAAGTCTTGTTTTTTGGTTTATTTTACTGTTTTGTGATCTTGTATG
CAAATCCTGATAACCATTAACCTTCTCAAACTTAATGTCTGAGAGCCTCATAAAATCAACATATTTACTTATTAAGCAGTTTATGAAACT

>5269_5269_1_AP3B1-MRPS36_AP3B1_chr5_77385216_ENST00000255194_MRPS36_chr5_68522164_ENST00000256441_length(amino acids)=985AA_BP=894
MRALLRTRTSFVPCPLDWNLLERTPGRTNPAPASTAAMSSNSFPYNEQSGGGEATELGQEATSTISPSGAFGLFSSDLKKNEDLKQMLES
NKDSAKLDAMKRIVGMIAKGKNASELFPAVVKNVASKNIEIKKLVYVYLVRYAEEQQDLALLSISTFQRALKDPNQLIRASALRVLSSIR
VPIIVPIMMLAIKEASADLSPYVRKNAAHAIQKLYSLDPEQKEMLIEVIEKLLKDKSTLVAGSVVMAFEEVCPDRIDLIHKNYRKLCNLL
VDVEEWGQVVIIHMLTRYARTQFVSPWKEGDELEDNGKNFYESDDDQKEKTDKKKKPYTMDPDHRLLIRNTKPLLQSRNAAVVMAVAQLY
WHISPKSEAGIISKSLVRLLRSNREVQYIVLQNIATMSIQRKGMFEPYLKSFYVRSTDPTMIKTLKLEILTNLANEANISTLLREFQTYV
KSQDKQFAAATIQTIGRCATNILEVTDTCLNGLVCLLSNRDEIVVAESVVVIKKLLQMQPAQHGEIIKHMAKLLDSITVPVARASILWLI
GENCERVPKIAPDVLRKMAKSFTSEDDLVKLQILNLGAKLYLTNSKQTKLLTQYILNLGKYDQNYDIRDRTRFIRQLIVPNVKSGALSKY
AKKIFLAQKPAPLLESPFKDRDHFQLGTLSHTLNIKATGYLELSNWPEVAPDPSVRNVEVIELAKEWTPAGKAKQENSAKKFYSESEEEE
DSSDSSSDSESESGSESGEQGESGEEGDSNEDSSEDSSSEQDSESGRESGLENKRTAKRNSKAKGKSDSEDGEKENEKSKTSDSSNDESS
SIEDSSSDSESESEPESESESRRVTKEKEKKTKQDRTPLTKDVSLLDLDDFNPVSTPVALPTPALSPSLMADLEGLHLSTSSSVISVVKP

--------------------------------------------------------------
>5269_5269_2_AP3B1-MRPS36_AP3B1_chr5_77385216_ENST00000519295_MRPS36_chr5_68522164_ENST00000256441_length(transcript)=3876nt_BP=2702nt
GCCTGCGCGCGCTCCTCCGTACGAGAACTAGTTTTGTTCCGTGCCCTCTGGACTGGAACCTTTTGGAGAGAACCCCCGGCAGGACCAACC
CCGCACCCGCCAGCACCGCGGCAATGTCCAGCAATAGTTTTCCTTACAATGAGCAGTCCGGAGGAGGGGAGGCGACGGAGCTGGGTCAGG
AGGCGACCTCAACCATTTCCCCCTCGGGGGCCTTCGGCCTCTTTAGCAGCGATTTGAAGAAGTGAGGAGAAAGGAATGAAGATCTAAAGC
AAATGTTAGAGAGCAACAAAGATTCTGCTAAACTGGATGCTATGAAGCGGATTGTTGGGATGATTGCAAAAGGGAAAAATGCATCTGAAC
TGTTTCCTGCTGTTGTGAAGAATGTGGCCAGTAAAAATATTGAGATCAAGAAGTTGGTATATGTTTACCTGGTTCGATATGCTGAAGAAC
AGCAGGATCTTGCACTCCTGTCCATAAGCACTTTTCAGCGAGCTCTGAAGGACCCAAACCAACTAATTCGTGCAAGCGCTTTGAGAGTTC
TGTCAAGTATTAGAGTGCCAATTATTGTACCTATCATGATGCTTGCTATTAAGGAAGCTTCTGCTGACTTATCACCATATGTTAGGAAGA
ATGCAGCCCATGCAATACAAAAATTATACAGCCTTGATCCAGAGCAGAAGGAAATGTTAATTGAAGTAATTGAAAAACTTCTGAAAGATA
AAAGCACATTGGTAGCTGGCAGTGTTGTGATGGCTTTTGAAGAAGTATGCCCGGACAGAATAGATCTGATTCATAAAAATTACCGCAAGC
TATGTAACTTACTAGTGGATGTTGAAGAGTGGGGGCAGGTTGTCATAATCCACATGCTAACTCGATATGCTCGGACACAGTTTGTCAGCC
CTTGGAAAGAGGGTGATGAATTAGAAGACAATGGAAAGAATTTCTACGAATCTGATGATGATCAGAAGGAAAAGACTGACAAAAAGAAGA
AGCCGTATACTATGGATCCAGATCATAGACTCTTAATTAGAAATACAAAGCCTTTGCTTCAGAGCAGGAATGCTGCGGTGGTTATGGCAG
TTGCTCAGCTGTATTGGCACATATCACCAAAATCTGAAGCTGGCATAATTTCTAAATCACTAGTGCGTTTACTTCGTAGCAATAGGGAGG
TGCAGTATATTGTCCTACAAAATATAGCAACTATGTCAATTCAAAGAAAGGGGATGTTTGAACCTTATCTGAAGAGTTTCTATGTTAGGT
CAACTGATCCAACTATGATCAAGACACTGAAGCTTGAAATTTTGACAAACTTGGCAAATGAAGCCAACATATCAACTCTTCTTCGAGAAT
TTCAGACCTATGTGAAAAGCCAGGATAAACAATTTGCAGCAGCCACTATTCAGACTATAGGCAGATGTGCAACCAACATCTTGGAAGTCA
CTGACACGTGCCTCAATGGCTTGGTCTGTCTGCTGTCCAACAGGGATGAAATAGTTGTTGCTGAAAGTGTGGTTGTTATAAAGAAATTAC
TGCAAATGCAACCTGCACAACATGGTGAAATTATTAAACATATGGCCAAACTCCTGGACAGTATCACTGTTCCTGTTGCTAGAGCAAGTA
TTCTTTGGCTAATTGGAGAAAACTGTGAACGAGTTCCTAAAATTGCCCCTGATGTTTTGAGGAAGATGGCTAAAAGCTTCACTAGTGAAG
ATGATCTGGTAAAACTGCAGATATTAAATCTGGGAGCAAAATTGTATTTAACCAACTCCAAACAGACAAAATTGCTTACCCAGTACATAT
TAAATCTCGGCAAGTATGATCAAAACTACGACATCAGAGACCGTACAAGATTTATTAGGCAGCTTATTGTTCCGAATGTAAAGAGTGGAG
CTTTAAGTAAATATGCCAAAAAAATATTCCTAGCACAAAAGCCTGCACCACTGCTTGAGTCTCCTTTTAAAGATAGAGATCATTTCCAGC
TTGGCACCTTATCTCATACTCTCAACATTAAAGCTACTGGGTACCTGGAATTATCTAATTGGCCAGAGGTGGCGCCCGACCCATCAGTTC
GAAATGTAGAAGTAATAGAGTTGGCAAAAGAATGGACCCCAGCAGGAAAAGCAAAGCAAGAGAATTCTGCTAAGAAGTTTTATTCTGAAT
CTGAGGAAGAGGAGGACTCTTCTGATAGTAGCAGTGACAGTGAGAGTGAATCTGGAAGTGAAAGTGGAGAACAAGGCGAAAGTGGGGAGG
AAGGAGACAGCAATGAGGACAGCAGTGAGGACTCCTCCAGTGAGCAGGACAGTGAGAGTGGACGGGAGTCAGGCCTAGAAAACAAAAGAA
CAGCCAAGAGGAACTCAAAAGCCAAAGGAAAAAGTGATTCTGAAGATGGGGAGAAGGAAAATGAAAAATCTAAAACTTCAGATTCTTCAA
ATGACGAATCTAGTTCAATAGAAGACAGTTCTTCCGATTCTGAATCAGAGTCAGAACCTGAAAGTGAATCTGAATCCAGAAGAGTCACTA
AGGAGAAAGAAAAGAAAACAAAGCAAGATAGAACTCCTCTTACCAAAGATGTTTCACTTCTAGATCTGGATGATTTTAACCCAGTATCCA
CTCCAGTTGCACTTCCCACACCAGCTCTTTCTCCAAGTTTGATGGCTGATCTTGAAGGTTTACACTTGTCAACTTCCTCTTCAGTCATCA
GTGTAGTCAAACCACACACTCCATTAATAAGGTTTCCTGACAGAAGAGACAATCCTAAACCCAATGTATCAGAAGCTTTGAGATCAGCAG
GGCTACCATCTCACTCTTCTGTAATTTCACAACATTCTAAAGGAAGTAAATCACCAGATTTGCTGATGTATCAGGGTCCACCAGACACTG
CAGAAATAATAAAAACATTACCTCAGAAATACAGAAGGAAACTTGTGTCTCAAGAAGAAATGGAATTTATCCAACGTGGAGGTCCTGAAT
AACCATGGTGGCTGCTGTTTGTCATCAGACAATAGAATTGTCTTTACAATAAAGGACTTCCAAAATGACAGATGAGAAACTGTATATTAA
ACACCTTTAATAAATATTATGAAAAAAATGAAATATAGAAAATTTAGATGGACACTTGTATTTCCTAATTTATGTATCTTGGTCAGCTTC
TCCACAAGCTTACCTAATTGTTTATATACTTTATACTTATTAAAGTATACATTTTTAAATGTTAGCCTATTAATTTACTCTTGATTATCA
AACATTACCAGTGTTGAACTATTAAAAGCACACAATGTGTAGTAAACTATCATAGGATTCCCATAATTTCACTTTACTTTCTGTTTAGGC
ATGGAAAAATTTATCAGTCAGAATTGCTGTTTTAGGGACATGATTTTCCTGAAATTGGGTGAGGATCAGTGAAATAATTACTCTATTACT
TGTTCTTAATTCTCTGTTCTCTAATGTTTTTTCATTCACAAGTTTACTGGAGTATAACTGGCTTAGTAAGTATATCCTACTCTGAATGAT
AAAAATATAGTCAAGCTAAAATAGGTGACTATACTATTAAGATAGAGATCATACAAAAGATTCCAAAGAAAGTCAAAAAGTGTAAAATGG
AAAATAAGAGATCAAAATGAATATAGCATAGGAATAAAGATTTCACTAGAAATTGCAATTTATTATGTTTTGGAGGTTGTAAGGAAGTCT
TGTTTTTTGGTTTATTTTACTGTTTTGTGATCTTGTATGCAAATCCTGATAACCATTAACCTTCTCAAACTTAATGTCTGAGAGCCTCAT
AAAATCAACATATTTACTTATTAAGCAGTTTATGAAACTTTAATGGGGCCCCTCCTGTGCCAAGGGTACGTATATTGTGAAGTAAAGCCT

>5269_5269_2_AP3B1-MRPS36_AP3B1_chr5_77385216_ENST00000519295_MRPS36_chr5_68522164_ENST00000256441_length(amino acids)=899AA_BP=808
MLESNKDSAKLDAMKRIVGMIAKGKNASELFPAVVKNVASKNIEIKKLVYVYLVRYAEEQQDLALLSISTFQRALKDPNQLIRASALRVL
SSIRVPIIVPIMMLAIKEASADLSPYVRKNAAHAIQKLYSLDPEQKEMLIEVIEKLLKDKSTLVAGSVVMAFEEVCPDRIDLIHKNYRKL
CNLLVDVEEWGQVVIIHMLTRYARTQFVSPWKEGDELEDNGKNFYESDDDQKEKTDKKKKPYTMDPDHRLLIRNTKPLLQSRNAAVVMAV
AQLYWHISPKSEAGIISKSLVRLLRSNREVQYIVLQNIATMSIQRKGMFEPYLKSFYVRSTDPTMIKTLKLEILTNLANEANISTLLREF
QTYVKSQDKQFAAATIQTIGRCATNILEVTDTCLNGLVCLLSNRDEIVVAESVVVIKKLLQMQPAQHGEIIKHMAKLLDSITVPVARASI
LWLIGENCERVPKIAPDVLRKMAKSFTSEDDLVKLQILNLGAKLYLTNSKQTKLLTQYILNLGKYDQNYDIRDRTRFIRQLIVPNVKSGA
LSKYAKKIFLAQKPAPLLESPFKDRDHFQLGTLSHTLNIKATGYLELSNWPEVAPDPSVRNVEVIELAKEWTPAGKAKQENSAKKFYSES
EEEEDSSDSSSDSESESGSESGEQGESGEEGDSNEDSSEDSSSEQDSESGRESGLENKRTAKRNSKAKGKSDSEDGEKENEKSKTSDSSN
DESSSIEDSSSDSESESEPESESESRRVTKEKEKKTKQDRTPLTKDVSLLDLDDFNPVSTPVALPTPALSPSLMADLEGLHLSTSSSVIS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for AP3B1-MRPS36

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for AP3B1-MRPS36

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for AP3B1-MRPS36

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source