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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MED24-CEP112 (FusionGDB2 ID:52708)

Fusion Gene Summary for MED24-CEP112

check button Fusion gene summary
Fusion gene informationFusion gene name: MED24-CEP112
Fusion gene ID: 52708
HgeneTgene
Gene symbol

MED24

CEP112

Gene ID

9862

201134

Gene namemediator complex subunit 24centrosomal protein 112
SynonymsARC100|CRSP100|CRSP4|DRIP100|MED5|THRAP4|TRAP100CCDC46|MACOCO
Cytomap

17q21.1

17q24.1

Type of geneprotein-codingprotein-coding
Descriptionmediator of RNA polymerase II transcription subunit 24CRSP complex subunit 4activator-recruited cofactor 100 kDa componentcofactor required for Sp1 transcriptional activation subunit 4cofactor required for Sp1 transcriptional activation, subunit 4, 10centrosomal protein of 112 kDacentrosomal protein 112kDacoiled-coil domain-containing protein 46
Modification date2020031320200313
UniProtAcc

O75448

Q8N8E3

Ensembl transtripts involved in fusion geneENST00000356271, ENST00000394126, 
ENST00000394127, ENST00000394128, 
ENST00000501516, ENST00000479829, 
ENST00000317442, ENST00000580482, 
ENST00000392769, ENST00000535342, 
ENST00000537949, ENST00000541355, 
Fusion gene scores* DoF score21 X 18 X 9=340222 X 17 X 10=3740
# samples 2621
** MAII scorelog2(26/3402*10)=-3.70979961263493
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/3740*10)=-4.15457703710888
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MED24 [Title/Abstract] AND CEP112 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMED24(38209551)-CEP112(63957716), # samples:3
Anticipated loss of major functional domain due to fusion event.MED24-CEP112 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
MED24-CEP112 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMED24

GO:0006367

transcription initiation from RNA polymerase II promoter

12218053

HgeneMED24

GO:0045893

positive regulation of transcription, DNA-templated

10198638


check buttonFusion gene breakpoints across MED24 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CEP112 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A076-01AMED24chr17

38209551

-CEP112chr17

63957716

-


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Fusion Gene ORF analysis for MED24-CEP112

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000356271ENST00000317442MED24chr17

38209551

-CEP112chr17

63957716

-
5CDS-intronENST00000356271ENST00000580482MED24chr17

38209551

-CEP112chr17

63957716

-
5CDS-intronENST00000394126ENST00000317442MED24chr17

38209551

-CEP112chr17

63957716

-
5CDS-intronENST00000394126ENST00000580482MED24chr17

38209551

-CEP112chr17

63957716

-
5CDS-intronENST00000394127ENST00000317442MED24chr17

38209551

-CEP112chr17

63957716

-
5CDS-intronENST00000394127ENST00000580482MED24chr17

38209551

-CEP112chr17

63957716

-
5CDS-intronENST00000394128ENST00000317442MED24chr17

38209551

-CEP112chr17

63957716

-
5CDS-intronENST00000394128ENST00000580482MED24chr17

38209551

-CEP112chr17

63957716

-
5CDS-intronENST00000501516ENST00000317442MED24chr17

38209551

-CEP112chr17

63957716

-
5CDS-intronENST00000501516ENST00000580482MED24chr17

38209551

-CEP112chr17

63957716

-
5UTR-3CDSENST00000479829ENST00000392769MED24chr17

38209551

-CEP112chr17

63957716

-
5UTR-3CDSENST00000479829ENST00000535342MED24chr17

38209551

-CEP112chr17

63957716

-
5UTR-3CDSENST00000479829ENST00000537949MED24chr17

38209551

-CEP112chr17

63957716

-
5UTR-3CDSENST00000479829ENST00000541355MED24chr17

38209551

-CEP112chr17

63957716

-
5UTR-intronENST00000479829ENST00000317442MED24chr17

38209551

-CEP112chr17

63957716

-
5UTR-intronENST00000479829ENST00000580482MED24chr17

38209551

-CEP112chr17

63957716

-
Frame-shiftENST00000356271ENST00000392769MED24chr17

38209551

-CEP112chr17

63957716

-
Frame-shiftENST00000356271ENST00000535342MED24chr17

38209551

-CEP112chr17

63957716

-
Frame-shiftENST00000356271ENST00000537949MED24chr17

38209551

-CEP112chr17

63957716

-
Frame-shiftENST00000356271ENST00000541355MED24chr17

38209551

-CEP112chr17

63957716

-
Frame-shiftENST00000394126ENST00000392769MED24chr17

38209551

-CEP112chr17

63957716

-
Frame-shiftENST00000394126ENST00000535342MED24chr17

38209551

-CEP112chr17

63957716

-
Frame-shiftENST00000394126ENST00000537949MED24chr17

38209551

-CEP112chr17

63957716

-
Frame-shiftENST00000394126ENST00000541355MED24chr17

38209551

-CEP112chr17

63957716

-
Frame-shiftENST00000394128ENST00000392769MED24chr17

38209551

-CEP112chr17

63957716

-
Frame-shiftENST00000394128ENST00000535342MED24chr17

38209551

-CEP112chr17

63957716

-
Frame-shiftENST00000394128ENST00000537949MED24chr17

38209551

-CEP112chr17

63957716

-
Frame-shiftENST00000394128ENST00000541355MED24chr17

38209551

-CEP112chr17

63957716

-
Frame-shiftENST00000501516ENST00000392769MED24chr17

38209551

-CEP112chr17

63957716

-
Frame-shiftENST00000501516ENST00000535342MED24chr17

38209551

-CEP112chr17

63957716

-
Frame-shiftENST00000501516ENST00000537949MED24chr17

38209551

-CEP112chr17

63957716

-
Frame-shiftENST00000501516ENST00000541355MED24chr17

38209551

-CEP112chr17

63957716

-
In-frameENST00000394127ENST00000392769MED24chr17

38209551

-CEP112chr17

63957716

-
In-frameENST00000394127ENST00000535342MED24chr17

38209551

-CEP112chr17

63957716

-
In-frameENST00000394127ENST00000537949MED24chr17

38209551

-CEP112chr17

63957716

-
In-frameENST00000394127ENST00000541355MED24chr17

38209551

-CEP112chr17

63957716

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000394127MED24chr1738209551-ENST00000535342CEP112chr1763957716-18823173001448382
ENST00000394127MED24chr1738209551-ENST00000392769CEP112chr1763957716-18793173001448382
ENST00000394127MED24chr1738209551-ENST00000541355CEP112chr1763957716-13863173001235311
ENST00000394127MED24chr1738209551-ENST00000537949CEP112chr1763957716-15073173001448382

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000394127ENST00000535342MED24chr1738209551-CEP112chr1763957716-0.0016664540.9983335
ENST00000394127ENST00000392769MED24chr1738209551-CEP112chr1763957716-0.0016548930.99834514
ENST00000394127ENST00000541355MED24chr1738209551-CEP112chr1763957716-0.0024129890.99758697
ENST00000394127ENST00000537949MED24chr1738209551-CEP112chr1763957716-0.0040634810.9959365

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Fusion Genomic Features for MED24-CEP112


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MED24-CEP112


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:38209551/chr17:63957716)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MED24

O75448

CEP112

Q8N8E3

FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:16595664}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCEP112chr17:38209551chr17:63957716ENST0000031744207277_9540212.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMED24chr17:38209551chr17:63957716ENST00000356271-325128_13271977.0MotifNote=LXXLL motif 1
HgeneMED24chr17:38209551chr17:63957716ENST00000356271-325344_34871977.0MotifNote=LXXLL motif 2
HgeneMED24chr17:38209551chr17:63957716ENST00000356271-325448_45271977.0MotifNote=LXXLL motif 3
HgeneMED24chr17:38209551chr17:63957716ENST00000356271-325557_56171977.0MotifNote=LXXLL motif 4
HgeneMED24chr17:38209551chr17:63957716ENST00000356271-325788_79271977.0MotifNote=LXXLL motif 5
HgeneMED24chr17:38209551chr17:63957716ENST00000356271-325857_86171977.0MotifNote=LXXLL motif 6
HgeneMED24chr17:38209551chr17:63957716ENST00000394127-325128_13271977.0MotifNote=LXXLL motif 1
HgeneMED24chr17:38209551chr17:63957716ENST00000394127-325344_34871977.0MotifNote=LXXLL motif 2
HgeneMED24chr17:38209551chr17:63957716ENST00000394127-325448_45271977.0MotifNote=LXXLL motif 3
HgeneMED24chr17:38209551chr17:63957716ENST00000394127-325557_56171977.0MotifNote=LXXLL motif 4
HgeneMED24chr17:38209551chr17:63957716ENST00000394127-325788_79271977.0MotifNote=LXXLL motif 5
HgeneMED24chr17:38209551chr17:63957716ENST00000394127-325857_86171977.0MotifNote=LXXLL motif 6
HgeneMED24chr17:38209551chr17:63957716ENST00000394128-326128_13271990.0MotifNote=LXXLL motif 1
HgeneMED24chr17:38209551chr17:63957716ENST00000394128-326344_34871990.0MotifNote=LXXLL motif 2
HgeneMED24chr17:38209551chr17:63957716ENST00000394128-326448_45271990.0MotifNote=LXXLL motif 3
HgeneMED24chr17:38209551chr17:63957716ENST00000394128-326557_56171990.0MotifNote=LXXLL motif 4
HgeneMED24chr17:38209551chr17:63957716ENST00000394128-326788_79271990.0MotifNote=LXXLL motif 5
HgeneMED24chr17:38209551chr17:63957716ENST00000394128-326857_86171990.0MotifNote=LXXLL motif 6
TgeneCEP112chr17:38209551chr17:63957716ENST000003927691627277_954578956.0Coiled coilOntology_term=ECO:0000255
TgeneCEP112chr17:38209551chr17:63957716ENST000005353421627277_954578956.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for MED24-CEP112


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>52708_52708_1_MED24-CEP112_MED24_chr17_38209551_ENST00000394127_CEP112_chr17_63957716_ENST00000392769_length(transcript)=1879nt_BP=317nt
AAGTGCCAAAATGGCGATGCCTACCACCTAGAACTGGATTGTGCGCTCCATTTCTTTCACCTCAAAGCTGGCCGCCACCGCTGCCACCTG
CTCAGAGTGAAATAATGAAGGTGGTCAACCTGAAGCAAGCCATTTTGCAAGCCTGGAAGGAGCGCTGGAGTGACTACCAATGGGCAATCA
ACATGAAGAAATTCTTTCCTAAAGGAGCCACCTGGGATATTCTCAACCTGGCAGATGCGTTACTAGAGCAGGCCATGATTGGACCATCCC
CCAATCCTCTCATCTTGTCCTACCTGAAGTATGCCATTAGTTCCCAGGGAAAAAGAGGAGCAGCTAACTCGTGTGACTGAAGTTCAGAGG
TTGCAGGCCCAGCAGGCAGATGCCGCTCTGGAAGAGTTTAAGCGGCAGGTGGAACTGAACTCAGAGAAAGTCTATGCTGAAATGAAAGAG
CAGATGGAAAAAGTGGAGGCAGATCTAACTAGATCCAAATCTCTTCGTGAGAAACAATCAAAGGAGTTTTTATGGCAACTGGAGGACATC
AGACAGCGGTATGAACAACAGATAGTAGAGCTGAAGCTGGAGCATGAACAGGAGAAGACGCACCTATTACAGCAGCATAACGCAGAGAAG
GATAGCCTAGTCCGAGACCATGAACGGGAAATTGAAAACCTGGAAAAACAGCTTCGCGCTGCCAATATGGAGCACGAAAATCAAATTCAG
GAGTTCAAGAAACGAGATGCACAGGTTATTGCCGACATGGAGGCCCAGGTTCACAAGTTGAGAGAAGAATTGATCAATGTGAACTCACAG
CGGAAACAGCAGCTGGTAGAGCTTGGTCTTCTTCGTGAAGAGGAAAAGCAAAGGGCTACAAGGGAACATGAGATTGTCGTCAATAAACTG
AAGGCTGAATCAGAAAAGATGAAAATAGAGCTGAAAAAGACTCATGCTGCTGAGACAGAGATGACACTGGAAAAGGCCAACAGCAAGCTG
AAGCAGATTGAGAAGGAATACACTCAGAAGCTTGCCAAATCTTCACAGATCATAGCAGAACTTCAGACAACCATTTCCTCTCTGAAAGAA
GAGAACAGCCAGCAGCAGCTTGCTGCAGAAAGGCGGCTCCAGGATGTTAGACAAAAGTTTGAAGATGAGAAGAAGCAGCTGATTAGAGAT
AATGACCAAGCAATCAAGGTTTTACAAGATGAATTAGAAAACCGTTCTAATCAGGTGCGATGTGCAGAGAAAAAATTACAACACAAAGAA
TTGGAGTCACAGGAACAGATAACTTACATACGACAAGAATATGAAACAAAATTGAAAGGATTGATGCCAGCATCCCTAAGACAAGAACTT
GAAGACACCATTTCCTCCCTAAAATCACAGGTTAATTTTCTGCAAAAGAGAGCTTCCATCCTTCAGGAAGAACTGACTACATATCAAGGC
AGAAGGTAACTGCACGAGAGAATGCAACGGATGCAATTTCCAGGCTGTGCTGTGGACTTCTTCCAGCAGGTTTGAAGATTTGGATATTGT
AAACTGTGAGATCAGTGGCATTTTTTAAATCCTTAAATGTAATTAAGATCATAAAAACATGCATCATTCATACACTAGTGGGGTGGTTTT
ATTTGTGTCTGCCTAAGTTATTTTTTTAACATTCCTTTATTTCCGATTTTCATGTTTGTGTGCATTTGAGTATGTGCTGAGAACTGCTTA
TATTGGGCAAAGTGATTTCCTATGATATGCCTTGTTAATCCTTTTGCATAGAATTTTACCAGTTGCGTACGATCAAAATCACGTTTGTAG

>52708_52708_1_MED24-CEP112_MED24_chr17_38209551_ENST00000394127_CEP112_chr17_63957716_ENST00000392769_length(amino acids)=382AA_BP=5
MPLVPREKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVE
LKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGL
LREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQLAAE
RRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQ

--------------------------------------------------------------
>52708_52708_2_MED24-CEP112_MED24_chr17_38209551_ENST00000394127_CEP112_chr17_63957716_ENST00000535342_length(transcript)=1882nt_BP=317nt
AAGTGCCAAAATGGCGATGCCTACCACCTAGAACTGGATTGTGCGCTCCATTTCTTTCACCTCAAAGCTGGCCGCCACCGCTGCCACCTG
CTCAGAGTGAAATAATGAAGGTGGTCAACCTGAAGCAAGCCATTTTGCAAGCCTGGAAGGAGCGCTGGAGTGACTACCAATGGGCAATCA
ACATGAAGAAATTCTTTCCTAAAGGAGCCACCTGGGATATTCTCAACCTGGCAGATGCGTTACTAGAGCAGGCCATGATTGGACCATCCC
CCAATCCTCTCATCTTGTCCTACCTGAAGTATGCCATTAGTTCCCAGGGAAAAAGAGGAGCAGCTAACTCGTGTGACTGAAGTTCAGAGG
TTGCAGGCCCAGCAGGCAGATGCCGCTCTGGAAGAGTTTAAGCGGCAGGTGGAACTGAACTCAGAGAAAGTCTATGCTGAAATGAAAGAG
CAGATGGAAAAAGTGGAGGCAGATCTAACTAGATCCAAATCTCTTCGTGAGAAACAATCAAAGGAGTTTTTATGGCAACTGGAGGACATC
AGACAGCGGTATGAACAACAGATAGTAGAGCTGAAGCTGGAGCATGAACAGGAGAAGACGCACCTATTACAGCAGCATAACGCAGAGAAG
GATAGCCTAGTCCGAGACCATGAACGGGAAATTGAAAACCTGGAAAAACAGCTTCGCGCTGCCAATATGGAGCACGAAAATCAAATTCAG
GAGTTCAAGAAACGAGATGCACAGGTTATTGCCGACATGGAGGCCCAGGTTCACAAGTTGAGAGAAGAATTGATCAATGTGAACTCACAG
CGGAAACAGCAGCTGGTAGAGCTTGGTCTTCTTCGTGAAGAGGAAAAGCAAAGGGCTACAAGGGAACATGAGATTGTCGTCAATAAACTG
AAGGCTGAATCAGAAAAGATGAAAATAGAGCTGAAAAAGACTCATGCTGCTGAGACAGAGATGACACTGGAAAAGGCCAACAGCAAGCTG
AAGCAGATTGAGAAGGAATACACTCAGAAGCTTGCCAAATCTTCACAGATCATAGCAGAACTTCAGACAACCATTTCCTCTCTGAAAGAA
GAGAACAGCCAGCAGCAGCTTGCTGCAGAAAGGCGGCTCCAGGATGTTAGACAAAAGTTTGAAGATGAGAAGAAGCAGCTGATTAGAGAT
AATGACCAAGCAATCAAGGTTTTACAAGATGAATTAGAAAACCGTTCTAATCAGGTGCGATGTGCAGAGAAAAAATTACAACACAAAGAA
TTGGAGTCACAGGAACAGATAACTTACATACGACAAGAATATGAAACAAAATTGAAAGGATTGATGCCAGCATCCCTAAGACAAGAACTT
GAAGACACCATTTCCTCCCTAAAATCACAGGTTAATTTTCTGCAAAAGAGAGCTTCCATCCTTCAGGAAGAACTGACTACATATCAAGGC
AGAAGGTAACTGCACGAGAGAATGCAACGGATGCAATTTCCAGGCTGTGCTGTGGACTTCTTCCAGCAGGTTTGAAGATTTGGATATTGT
AAACTGTGAGATCAGTGGCATTTTTTAAATCCTTAAATGTAATTAAGATCATAAAAACATGCATCATTCATACACTAGTGGGGTGGTTTT
ATTTGTGTCTGCCTAAGTTATTTTTTTAACATTCCTTTATTTCCGATTTTCATGTTTGTGTGCATTTGAGTATGTGCTGAGAACTGCTTA
TATTGGGCAAAGTGATTTCCTATGATATGCCTTGTTAATCCTTTTGCATAGAATTTTACCAGTTGCGTACGATCAAAATCACGTTTGTAG

>52708_52708_2_MED24-CEP112_MED24_chr17_38209551_ENST00000394127_CEP112_chr17_63957716_ENST00000535342_length(amino acids)=382AA_BP=5
MPLVPREKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVE
LKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGL
LREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQLAAE
RRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQ

--------------------------------------------------------------
>52708_52708_3_MED24-CEP112_MED24_chr17_38209551_ENST00000394127_CEP112_chr17_63957716_ENST00000537949_length(transcript)=1507nt_BP=317nt
AAGTGCCAAAATGGCGATGCCTACCACCTAGAACTGGATTGTGCGCTCCATTTCTTTCACCTCAAAGCTGGCCGCCACCGCTGCCACCTG
CTCAGAGTGAAATAATGAAGGTGGTCAACCTGAAGCAAGCCATTTTGCAAGCCTGGAAGGAGCGCTGGAGTGACTACCAATGGGCAATCA
ACATGAAGAAATTCTTTCCTAAAGGAGCCACCTGGGATATTCTCAACCTGGCAGATGCGTTACTAGAGCAGGCCATGATTGGACCATCCC
CCAATCCTCTCATCTTGTCCTACCTGAAGTATGCCATTAGTTCCCAGGGAAAAAGAGGAGCAGCTAACTCGTGTGACTGAAGTTCAGAGG
TTGCAGGCCCAGCAGGCAGATGCCGCTCTGGAAGAGTTTAAGCGGCAGGTGGAACTGAACTCAGAGAAAGTCTATGCTGAAATGAAAGAG
CAGATGGAAAAAGTGGAGGCAGATCTAACTAGATCCAAATCTCTTCGTGAGAAACAATCAAAGGAGTTTTTATGGCAACTGGAGGACATC
AGACAGCGGTATGAACAACAGATAGTAGAGCTGAAGCTGGAGCATGAACAGGAGAAGACGCACCTATTACAGCAGCATAACGCAGAGAAG
GATAGCCTAGTCCGAGACCATGAACGGGAAATTGAAAACCTGGAAAAACAGCTTCGCGCTGCCAATATGGAGCACGAAAATCAAATTCAG
GAGTTCAAGAAACGAGATGCACAGGTTATTGCCGACATGGAGGCCCAGGTTCACAAGTTGAGAGAAGAATTGATCAATGTGAACTCACAG
CGGAAACAGCAGCTGGTAGAGCTTGGTCTTCTTCGTGAAGAGGAAAAGCAAAGGGCTACAAGGGAACATGAGATTGTCGTCAATAAACTG
AAGGCTGAATCAGAAAAGATGAAAATAGAGCTGAAAAAGACTCATGCTGCTGAGACAGAGATGACACTGGAAAAGGCCAACAGCAAGCTG
AAGCAGATTGAGAAGGAATACACTCAGAAGCTTGCCAAATCTTCACAGATCATAGCAGAACTTCAGACAACCATTTCCTCTCTGAAAGAA
GAGAACAGCCAGCAGCAGCTTGCTGCAGAAAGGCGGCTCCAGGATGTTAGACAAAAGTTTGAAGATGAGAAGAAGCAGCTGATTAGAGAT
AATGACCAAGCAATCAAGGTTTTACAAGATGAATTAGAAAACCGTTCTAATCAGGTGCGATGTGCAGAGAAAAAATTACAACACAAAGAA
TTGGAGTCACAGGAACAGATAACTTACATACGACAAGAATATGAAACAAAATTGAAAGGATTGATGCCAGCATCCCTAAGACAAGAACTT
GAAGACACCATTTCCTCCCTAAAATCACAGGTTAATTTTCTGCAAAAGAGAGCTTCCATCCTTCAGGAAGAACTGACTACATATCAAGGC

>52708_52708_3_MED24-CEP112_MED24_chr17_38209551_ENST00000394127_CEP112_chr17_63957716_ENST00000537949_length(amino acids)=382AA_BP=5
MPLVPREKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVE
LKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGL
LREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQLAAE
RRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQ

--------------------------------------------------------------
>52708_52708_4_MED24-CEP112_MED24_chr17_38209551_ENST00000394127_CEP112_chr17_63957716_ENST00000541355_length(transcript)=1386nt_BP=317nt
AAGTGCCAAAATGGCGATGCCTACCACCTAGAACTGGATTGTGCGCTCCATTTCTTTCACCTCAAAGCTGGCCGCCACCGCTGCCACCTG
CTCAGAGTGAAATAATGAAGGTGGTCAACCTGAAGCAAGCCATTTTGCAAGCCTGGAAGGAGCGCTGGAGTGACTACCAATGGGCAATCA
ACATGAAGAAATTCTTTCCTAAAGGAGCCACCTGGGATATTCTCAACCTGGCAGATGCGTTACTAGAGCAGGCCATGATTGGACCATCCC
CCAATCCTCTCATCTTGTCCTACCTGAAGTATGCCATTAGTTCCCAGGGAAAAAGAGGAGCAGCTAACTCGTGTGACTGAAGTTCAGAGG
TTGCAGGCCCAGCAGGCAGATGCCGCTCTGGAAGAGTTTAAGCGGCAGGTGGAACTGAACTCAGAGAAAGTCTATGCTGAAATGAAAGAG
CAGATGGAAAAAGTGGAGGCAGATCTAACTAGATCCAAATCTCTTCGTGAGAAACAATCAAAGGAGTTTTTATGGCAACTGGAGGACATC
AGACAGCGGTATGAACAACAGATAGTAGAGCTGAAGCTGGAGCATGAACAGGAGAAGACGCACCTATTACAGCAGCATAACGCAGAGAAG
GATAGCCTAGTCCGAGACCATGAACGGGAAATTGAAAACCTGGAAAAACAGCTTCGCGCTGCCAATATGGAGCACGAAAATCAAATTCAG
GAGTTCAAGAAACGAGATGCACAGGTTATTGCCGACATGGAGGCCCAGGTTCACAAGTTGAGAGAAGAATTGATCAATGTGAACTCACAG
CGGAAACAGCAGCTGGTAGAGCTTGGTCTTCTTCGTGAAGAGGAAAAGCAAAGGGCTACAAGGGAACATGAGATTGTCGTCAATAAACTG
AAGGCTGAATCAGAAAAGATGAAAATAGAGCTGAAAAAGACTCATGCTGCTGAGACAGAGATGACACTGGAAAAGGTTTTACAAGATGAA
TTAGAAAACCGTTCTAATCAGGTGCGATGTGCAGAGAAAAAATTACAACACAAAGAATTGGAGTCACAGGAACAGATAACTTACATACGA
CAAGAATATGAAACAAAATTGAAAGGATTGATGCCAGCATCCCTAAGACAAGAACTTGAAGACACCATTTCCTCCCTAAAATCACAGGTT
AATTTTCTGCAAAAGAGAGCTTCCATCCTTCAGGAAGAACTGACTACATATCAAGGCAGAAGGTAACTGCACGAGAGAATGCAACGGATG
CAATTTCCAGGCTGTGCTGTGGACTTCTTCCAGCAGGTTTGAAGATTTGGATATTGTAAACTGTGAGATCAGTGGCATTTTTTAAATCCT

>52708_52708_4_MED24-CEP112_MED24_chr17_38209551_ENST00000394127_CEP112_chr17_63957716_ENST00000541355_length(amino acids)=311AA_BP=5
MPLVPREKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVE
LKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGL
LREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MED24-CEP112


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MED24-CEP112


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MED24-CEP112


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource