FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:MED24-CEP95 (FusionGDB2 ID:52709)

Fusion Gene Summary for MED24-CEP95

check button Fusion gene summary
Fusion gene informationFusion gene name: MED24-CEP95
Fusion gene ID: 52709
HgeneTgene
Gene symbol

MED24

CEP95

Gene ID

9862

90799

Gene namemediator complex subunit 24centrosomal protein 95
SynonymsARC100|CRSP100|CRSP4|DRIP100|MED5|THRAP4|TRAP100CCDC45
Cytomap

17q21.1

17q23.3

Type of geneprotein-codingprotein-coding
Descriptionmediator of RNA polymerase II transcription subunit 24CRSP complex subunit 4activator-recruited cofactor 100 kDa componentcofactor required for Sp1 transcriptional activation subunit 4cofactor required for Sp1 transcriptional activation, subunit 4, 10centrosomal protein of 95 kDacentrosomal protein 95kDacoiled-coil domain containing 45coiled-coil domain-containing protein 45
Modification date2020031320200313
UniProtAcc

O75448

Q96GE4

Ensembl transtripts involved in fusion geneENST00000356271, ENST00000394126, 
ENST00000394127, ENST00000394128, 
ENST00000501516, ENST00000479829, 
ENST00000577476, ENST00000581056, 
ENST00000553412, ENST00000556440, 
Fusion gene scores* DoF score21 X 18 X 9=34026 X 7 X 3=126
# samples 267
** MAII scorelog2(26/3402*10)=-3.70979961263493
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MED24 [Title/Abstract] AND CEP95 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMED24(38209551)-CEP95(62517520), # samples:3
Anticipated loss of major functional domain due to fusion event.MED24-CEP95 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
MED24-CEP95 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
MED24-CEP95 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMED24

GO:0006367

transcription initiation from RNA polymerase II promoter

12218053

HgeneMED24

GO:0045893

positive regulation of transcription, DNA-templated

10198638


check buttonFusion gene breakpoints across MED24 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CEP95 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-B6-A0IG-01AMED24chr17

38209551

-CEP95chr17

62517520

+
ChimerDB4BRCATCGA-B6-A0IG-01AMED24chr17

38209551

-CEP95chr17

62521888

+


Top

Fusion Gene ORF analysis for MED24-CEP95

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000356271ENST00000577476MED24chr17

38209551

-CEP95chr17

62517520

+
5CDS-intronENST00000356271ENST00000577476MED24chr17

38209551

-CEP95chr17

62521888

+
5CDS-intronENST00000356271ENST00000581056MED24chr17

38209551

-CEP95chr17

62517520

+
5CDS-intronENST00000356271ENST00000581056MED24chr17

38209551

-CEP95chr17

62521888

+
5CDS-intronENST00000394126ENST00000577476MED24chr17

38209551

-CEP95chr17

62517520

+
5CDS-intronENST00000394126ENST00000577476MED24chr17

38209551

-CEP95chr17

62521888

+
5CDS-intronENST00000394126ENST00000581056MED24chr17

38209551

-CEP95chr17

62517520

+
5CDS-intronENST00000394126ENST00000581056MED24chr17

38209551

-CEP95chr17

62521888

+
5CDS-intronENST00000394127ENST00000577476MED24chr17

38209551

-CEP95chr17

62517520

+
5CDS-intronENST00000394127ENST00000577476MED24chr17

38209551

-CEP95chr17

62521888

+
5CDS-intronENST00000394127ENST00000581056MED24chr17

38209551

-CEP95chr17

62517520

+
5CDS-intronENST00000394127ENST00000581056MED24chr17

38209551

-CEP95chr17

62521888

+
5CDS-intronENST00000394128ENST00000577476MED24chr17

38209551

-CEP95chr17

62517520

+
5CDS-intronENST00000394128ENST00000577476MED24chr17

38209551

-CEP95chr17

62521888

+
5CDS-intronENST00000394128ENST00000581056MED24chr17

38209551

-CEP95chr17

62517520

+
5CDS-intronENST00000394128ENST00000581056MED24chr17

38209551

-CEP95chr17

62521888

+
5CDS-intronENST00000501516ENST00000577476MED24chr17

38209551

-CEP95chr17

62517520

+
5CDS-intronENST00000501516ENST00000577476MED24chr17

38209551

-CEP95chr17

62521888

+
5CDS-intronENST00000501516ENST00000581056MED24chr17

38209551

-CEP95chr17

62517520

+
5CDS-intronENST00000501516ENST00000581056MED24chr17

38209551

-CEP95chr17

62521888

+
5UTR-3CDSENST00000479829ENST00000553412MED24chr17

38209551

-CEP95chr17

62517520

+
5UTR-3CDSENST00000479829ENST00000553412MED24chr17

38209551

-CEP95chr17

62521888

+
5UTR-3CDSENST00000479829ENST00000556440MED24chr17

38209551

-CEP95chr17

62517520

+
5UTR-3CDSENST00000479829ENST00000556440MED24chr17

38209551

-CEP95chr17

62521888

+
5UTR-intronENST00000479829ENST00000577476MED24chr17

38209551

-CEP95chr17

62517520

+
5UTR-intronENST00000479829ENST00000577476MED24chr17

38209551

-CEP95chr17

62521888

+
5UTR-intronENST00000479829ENST00000581056MED24chr17

38209551

-CEP95chr17

62517520

+
5UTR-intronENST00000479829ENST00000581056MED24chr17

38209551

-CEP95chr17

62521888

+
Frame-shiftENST00000356271ENST00000553412MED24chr17

38209551

-CEP95chr17

62521888

+
Frame-shiftENST00000356271ENST00000556440MED24chr17

38209551

-CEP95chr17

62521888

+
Frame-shiftENST00000394126ENST00000553412MED24chr17

38209551

-CEP95chr17

62517520

+
Frame-shiftENST00000394126ENST00000556440MED24chr17

38209551

-CEP95chr17

62517520

+
Frame-shiftENST00000394127ENST00000553412MED24chr17

38209551

-CEP95chr17

62517520

+
Frame-shiftENST00000394127ENST00000553412MED24chr17

38209551

-CEP95chr17

62521888

+
Frame-shiftENST00000394127ENST00000556440MED24chr17

38209551

-CEP95chr17

62517520

+
Frame-shiftENST00000394127ENST00000556440MED24chr17

38209551

-CEP95chr17

62521888

+
Frame-shiftENST00000394128ENST00000553412MED24chr17

38209551

-CEP95chr17

62521888

+
Frame-shiftENST00000394128ENST00000556440MED24chr17

38209551

-CEP95chr17

62521888

+
Frame-shiftENST00000501516ENST00000553412MED24chr17

38209551

-CEP95chr17

62517520

+
Frame-shiftENST00000501516ENST00000556440MED24chr17

38209551

-CEP95chr17

62517520

+
In-frameENST00000356271ENST00000553412MED24chr17

38209551

-CEP95chr17

62517520

+
In-frameENST00000356271ENST00000556440MED24chr17

38209551

-CEP95chr17

62517520

+
In-frameENST00000394126ENST00000553412MED24chr17

38209551

-CEP95chr17

62521888

+
In-frameENST00000394126ENST00000556440MED24chr17

38209551

-CEP95chr17

62521888

+
In-frameENST00000394128ENST00000553412MED24chr17

38209551

-CEP95chr17

62517520

+
In-frameENST00000394128ENST00000556440MED24chr17

38209551

-CEP95chr17

62517520

+
In-frameENST00000501516ENST00000553412MED24chr17

38209551

-CEP95chr17

62521888

+
In-frameENST00000501516ENST00000556440MED24chr17

38209551

-CEP95chr17

62521888

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000356271MED24chr1738209551-ENST00000556440CEP95chr1762517520+23372973172173618
ENST00000356271MED24chr1738209551-ENST00000553412CEP95chr1762517520+23372973172173618
ENST00000394128MED24chr1738209551-ENST00000556440CEP95chr1762517520+23352953152171618
ENST00000394128MED24chr1738209551-ENST00000553412CEP95chr1762517520+23352953152171618
ENST00000394126MED24chr1738209551-ENST00000556440CEP95chr1762521888+24277074192263614
ENST00000394126MED24chr1738209551-ENST00000553412CEP95chr1762521888+24277074192263614
ENST00000501516MED24chr1738209551-ENST00000556440CEP95chr1762521888+1943223101779589
ENST00000501516MED24chr1738209551-ENST00000553412CEP95chr1762521888+1943223101779589

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000356271ENST00000556440MED24chr1738209551-CEP95chr1762517520+0.0033965460.9966035
ENST00000356271ENST00000553412MED24chr1738209551-CEP95chr1762517520+0.0033965460.9966035
ENST00000394128ENST00000556440MED24chr1738209551-CEP95chr1762517520+0.0033591720.9966408
ENST00000394128ENST00000553412MED24chr1738209551-CEP95chr1762517520+0.0033591720.9966408
ENST00000394126ENST00000556440MED24chr1738209551-CEP95chr1762521888+0.0019604050.99803966
ENST00000394126ENST00000553412MED24chr1738209551-CEP95chr1762521888+0.0019604050.99803966
ENST00000501516ENST00000556440MED24chr1738209551-CEP95chr1762521888+0.0025885090.99741155
ENST00000501516ENST00000553412MED24chr1738209551-CEP95chr1762521888+0.0025885090.99741155

Top

Fusion Genomic Features for MED24-CEP95


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for MED24-CEP95


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:38209551/chr17:62517520)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MED24

O75448

CEP95

Q96GE4

FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:16595664}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCEP95chr17:38209551chr17:62517520ENST00000556440520585_632196822.0Coiled coilOntology_term=ECO:0000255
TgeneCEP95chr17:38209551chr17:62517520ENST00000556440520700_794196822.0Coiled coilOntology_term=ECO:0000255
TgeneCEP95chr17:38209551chr17:62521888ENST00000556440720585_632303822.0Coiled coilOntology_term=ECO:0000255
TgeneCEP95chr17:38209551chr17:62521888ENST00000556440720700_794303822.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMED24chr17:38209551chr17:62517520ENST00000356271-325128_13271977.0MotifNote=LXXLL motif 1
HgeneMED24chr17:38209551chr17:62517520ENST00000356271-325344_34871977.0MotifNote=LXXLL motif 2
HgeneMED24chr17:38209551chr17:62517520ENST00000356271-325448_45271977.0MotifNote=LXXLL motif 3
HgeneMED24chr17:38209551chr17:62517520ENST00000356271-325557_56171977.0MotifNote=LXXLL motif 4
HgeneMED24chr17:38209551chr17:62517520ENST00000356271-325788_79271977.0MotifNote=LXXLL motif 5
HgeneMED24chr17:38209551chr17:62517520ENST00000356271-325857_86171977.0MotifNote=LXXLL motif 6
HgeneMED24chr17:38209551chr17:62517520ENST00000394127-325128_13271977.0MotifNote=LXXLL motif 1
HgeneMED24chr17:38209551chr17:62517520ENST00000394127-325344_34871977.0MotifNote=LXXLL motif 2
HgeneMED24chr17:38209551chr17:62517520ENST00000394127-325448_45271977.0MotifNote=LXXLL motif 3
HgeneMED24chr17:38209551chr17:62517520ENST00000394127-325557_56171977.0MotifNote=LXXLL motif 4
HgeneMED24chr17:38209551chr17:62517520ENST00000394127-325788_79271977.0MotifNote=LXXLL motif 5
HgeneMED24chr17:38209551chr17:62517520ENST00000394127-325857_86171977.0MotifNote=LXXLL motif 6
HgeneMED24chr17:38209551chr17:62517520ENST00000394128-326128_13271990.0MotifNote=LXXLL motif 1
HgeneMED24chr17:38209551chr17:62517520ENST00000394128-326344_34871990.0MotifNote=LXXLL motif 2
HgeneMED24chr17:38209551chr17:62517520ENST00000394128-326448_45271990.0MotifNote=LXXLL motif 3
HgeneMED24chr17:38209551chr17:62517520ENST00000394128-326557_56171990.0MotifNote=LXXLL motif 4
HgeneMED24chr17:38209551chr17:62517520ENST00000394128-326788_79271990.0MotifNote=LXXLL motif 5
HgeneMED24chr17:38209551chr17:62517520ENST00000394128-326857_86171990.0MotifNote=LXXLL motif 6
HgeneMED24chr17:38209551chr17:62521888ENST00000356271-325128_13271977.0MotifNote=LXXLL motif 1
HgeneMED24chr17:38209551chr17:62521888ENST00000356271-325344_34871977.0MotifNote=LXXLL motif 2
HgeneMED24chr17:38209551chr17:62521888ENST00000356271-325448_45271977.0MotifNote=LXXLL motif 3
HgeneMED24chr17:38209551chr17:62521888ENST00000356271-325557_56171977.0MotifNote=LXXLL motif 4
HgeneMED24chr17:38209551chr17:62521888ENST00000356271-325788_79271977.0MotifNote=LXXLL motif 5
HgeneMED24chr17:38209551chr17:62521888ENST00000356271-325857_86171977.0MotifNote=LXXLL motif 6
HgeneMED24chr17:38209551chr17:62521888ENST00000394127-325128_13271977.0MotifNote=LXXLL motif 1
HgeneMED24chr17:38209551chr17:62521888ENST00000394127-325344_34871977.0MotifNote=LXXLL motif 2
HgeneMED24chr17:38209551chr17:62521888ENST00000394127-325448_45271977.0MotifNote=LXXLL motif 3
HgeneMED24chr17:38209551chr17:62521888ENST00000394127-325557_56171977.0MotifNote=LXXLL motif 4
HgeneMED24chr17:38209551chr17:62521888ENST00000394127-325788_79271977.0MotifNote=LXXLL motif 5
HgeneMED24chr17:38209551chr17:62521888ENST00000394127-325857_86171977.0MotifNote=LXXLL motif 6
HgeneMED24chr17:38209551chr17:62521888ENST00000394128-326128_13271990.0MotifNote=LXXLL motif 1
HgeneMED24chr17:38209551chr17:62521888ENST00000394128-326344_34871990.0MotifNote=LXXLL motif 2
HgeneMED24chr17:38209551chr17:62521888ENST00000394128-326448_45271990.0MotifNote=LXXLL motif 3
HgeneMED24chr17:38209551chr17:62521888ENST00000394128-326557_56171990.0MotifNote=LXXLL motif 4
HgeneMED24chr17:38209551chr17:62521888ENST00000394128-326788_79271990.0MotifNote=LXXLL motif 5
HgeneMED24chr17:38209551chr17:62521888ENST00000394128-326857_86171990.0MotifNote=LXXLL motif 6


Top

Fusion Gene Sequence for MED24-CEP95


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>52709_52709_1_MED24-CEP95_MED24_chr17_38209551_ENST00000356271_CEP95_chr17_62517520_ENST00000553412_length(transcript)=2337nt_BP=297nt
ACAAGTGCCAAAATGGCGATGCCTACCACCTAGAACTGGATTGTGCGCTGGCCGCCACCGCTGCCACCTGCTCAGAGTGAAATAATGAAG
GTGGTCAACCTGAAGCAAGCCATTTTGCAAGCCTGGAAGGAGCGCTGGAGTGACTACCAATGGGCAATCAACATGAAGAAATTCTTTCCT
AAAGGAGCCACCTGGGATATTCTCAACCTGGCAGATGCGTTACTAGAGCAGGCCATGATTGGACCATCCCCCAATCCTCTCATCTTGTCC
TACCTGAAGTATGCCATTAGTTCCCAGGTGCTCAATGTCCTAATGAAATGCTGTCTAAAAAAGCCTTAGCCTCACCAAGTTCTAAATCAC
ATGAAGATATGTTGTACCCTCCTAGTGTTTTGTCCAAGAGTAGGACATCCTTTGTTGAAGACACGGAAACCCTTTCTGTGAGTGGGATTC
CAAATGCTAGGAAGCTAGGGGAGCCTATCCGAGCAGCTATTCCTTTACATCCACCCTACCACCCTTCAGAGCCTCGAGCACCCTGCCCCA
TAGGAAAAGAATACTTGCATTCAAGTCACTGCTCCCCAGCCGTAAATTCTACTGGAGAGCATACGGAATTTTCTGGGGATCTAGATGATG
GACTTTTCTTAATTTCCAAGTTGCCTAAAGGCAGCAAATGGGAAGTATATCCAGCTCAGGTCCAAGGGCCTAGGACAAGGAAGCCTCCCA
AAGGAAAAAGAAATGAAAACAGAGCTACAGCCTCATCCTGCAATTCACCTTTCCCCCAGAGGCCAAGAAAGAGATTAACAGAACAAGAAT
TACATGATGTATCAGAAAAACTCTCTCAGCGGCTTTCTGAACTAGATTGGATGTTAAAAAGTGCTCTGGGTGATCGGATTAAAGAAAAGA
CTGACCATAAAGAAGAAAATACTGGAAATGAGGAGGTAGAGGATGGAACTGAGGAGACACTGTCTCAGCACAGTGATGGCATCGTGGAGT
ATGGGCCAAAGAAGTCAAGGCCAGGACTTTCCATGCGTAGAAAGCCACCCTACAGATCCCATTCGCTCTCTCCATCTCCAGTTAACAAAC
ACAAACAGTTCCACTTGGAGAGAAAAAGGCAGCGCAAGCCAAGAGAAACAGATGTCCGCCAATTCCAAGCACAGGCGTTTACTGAAGCAT
TTGAAAGGGAACTAAGAAGACATAAAGTTCAAGAGAATATTGGACCTCTAAGAATACATGAGAAGGAGGAGGAAACAGAAAAAATATACA
GAGGAGAAGCTGTTCGTAAAGGAACTCCAGAATGTAGTCAGCCCTGGAAGATTTACTCTAGAAAAACCACAACGCAGAGTCTAAGAGGTG
GCCTCCCAAAGCCAAATAAAGCAGTTCCAATGAAAGTAAGTGAACACAGTCTCCTGCCCCTTATGCTGGAGCAGTTTCCGTTTCTTTATG
TTTCTGGCCCAACACTAAGCAAAATGTGGAAACAGCAAATTGCACAGGTTGAACAGCTTAAGAAAGAAGCATGTAGAGAAAATCGATCAA
AGAAGAAACTCCAAGATGAAATAGAAGAAGCCCTAAGAAGGCATGACCTCCTTACTACCCTTGTCAAGAAAGAATATGAACATAACAAGA
GACTGCAAGACTTCAAGGACTGCATTCGTAGGCAAAGGTTGACCCAATCAAAGATAAAAGAAAATCGACAGCAAATCGTTCGTGCTCGAA
AATATTATGATGATTATAGAGTTCAGTTGTGTGCAAAAATGATGAGAATGAGGACCCGGGAAGAAATGATATTTAAGAAACTGTTTGAAG
AAGGTTTAAACATTCAAAAGCAAAGATTACGAGACCTAAGAAACTATGCCAAAGAAAAGCGAGATGAACAAAGGAGACGCCACCAGGATG
AACTGGACTCCATGGAGAACTACTATAAGGACCAGTTTTCATTGCTGGCAGAAGCCATATCACAGGAACATCAAGAACTTAAAGCCAGAG
AGAAATCTCAGGCCCAGACATTACATAAGGTGAAGAGGGAGCTGAGATCTAAGATGGAGAAGGAAATTCAGCAGCTGCAGGACATGATAA
CACAGAATGATGATGATGTTTTCTTCCGGGAACTGGAAGCTGAGCGCTTCAGATCTCGGCTTCAGCTGGCTTCCTTTCAGTACAGTAAAA
GTCCCTCCCTATGAGGCCAGACTTGATAATAGTAGGTGAAGGTTCTGGAGGCCTTTACCAGGACAGAGCTAGAATCGAGCCAGTAAACAG

>52709_52709_1_MED24-CEP95_MED24_chr17_38209551_ENST00000356271_CEP95_chr17_62517520_ENST00000553412_length(amino acids)=618AA_BP=
MLSKKALASPSSKSHEDMLYPPSVLSKSRTSFVEDTETLSVSGIPNARKLGEPIRAAIPLHPPYHPSEPRAPCPIGKEYLHSSHCSPAVN
STGEHTEFSGDLDDGLFLISKLPKGSKWEVYPAQVQGPRTRKPPKGKRNENRATASSCNSPFPQRPRKRLTEQELHDVSEKLSQRLSELD
WMLKSALGDRIKEKTDHKEENTGNEEVEDGTEETLSQHSDGIVEYGPKKSRPGLSMRRKPPYRSHSLSPSPVNKHKQFHLERKRQRKPRE
TDVRQFQAQAFTEAFERELRRHKVQENIGPLRIHEKEEETEKIYRGEAVRKGTPECSQPWKIYSRKTTTQSLRGGLPKPNKAVPMKVSEH
SLLPLMLEQFPFLYVSGPTLSKMWKQQIAQVEQLKKEACRENRSKKKLQDEIEEALRRHDLLTTLVKKEYEHNKRLQDFKDCIRRQRLTQ
SKIKENRQQIVRARKYYDDYRVQLCAKMMRMRTREEMIFKKLFEEGLNIQKQRLRDLRNYAKEKRDEQRRRHQDELDSMENYYKDQFSLL

--------------------------------------------------------------
>52709_52709_2_MED24-CEP95_MED24_chr17_38209551_ENST00000356271_CEP95_chr17_62517520_ENST00000556440_length(transcript)=2337nt_BP=297nt
ACAAGTGCCAAAATGGCGATGCCTACCACCTAGAACTGGATTGTGCGCTGGCCGCCACCGCTGCCACCTGCTCAGAGTGAAATAATGAAG
GTGGTCAACCTGAAGCAAGCCATTTTGCAAGCCTGGAAGGAGCGCTGGAGTGACTACCAATGGGCAATCAACATGAAGAAATTCTTTCCT
AAAGGAGCCACCTGGGATATTCTCAACCTGGCAGATGCGTTACTAGAGCAGGCCATGATTGGACCATCCCCCAATCCTCTCATCTTGTCC
TACCTGAAGTATGCCATTAGTTCCCAGGTGCTCAATGTCCTAATGAAATGCTGTCTAAAAAAGCCTTAGCCTCACCAAGTTCTAAATCAC
ATGAAGATATGTTGTACCCTCCTAGTGTTTTGTCCAAGAGTAGGACATCCTTTGTTGAAGACACGGAAACCCTTTCTGTGAGTGGGATTC
CAAATGCTAGGAAGCTAGGGGAGCCTATCCGAGCAGCTATTCCTTTACATCCACCCTACCACCCTTCAGAGCCTCGAGCACCCTGCCCCA
TAGGAAAAGAATACTTGCATTCAAGTCACTGCTCCCCAGCCGTAAATTCTACTGGAGAGCATACGGAATTTTCTGGGGATCTAGATGATG
GACTTTTCTTAATTTCCAAGTTGCCTAAAGGCAGCAAATGGGAAGTATATCCAGCTCAGGTCCAAGGGCCTAGGACAAGGAAGCCTCCCA
AAGGAAAAAGAAATGAAAACAGAGCTACAGCCTCATCCTGCAATTCACCTTTCCCCCAGAGGCCAAGAAAGAGATTAACAGAACAAGAAT
TACATGATGTATCAGAAAAACTCTCTCAGCGGCTTTCTGAACTAGATTGGATGTTAAAAAGTGCTCTGGGTGATCGGATTAAAGAAAAGA
CTGACCATAAAGAAGAAAATACTGGAAATGAGGAGGTAGAGGATGGAACTGAGGAGACACTGTCTCAGCACAGTGATGGCATCGTGGAGT
ATGGGCCAAAGAAGTCAAGGCCAGGACTTTCCATGCGTAGAAAGCCACCCTACAGATCCCATTCGCTCTCTCCATCTCCAGTTAACAAAC
ACAAACAGTTCCACTTGGAGAGAAAAAGGCAGCGCAAGCCAAGAGAAACAGATGTCCGCCAATTCCAAGCACAGGCGTTTACTGAAGCAT
TTGAAAGGGAACTAAGAAGACATAAAGTTCAAGAGAATATTGGACCTCTAAGAATACATGAGAAGGAGGAGGAAACAGAAAAAATATACA
GAGGAGAAGCTGTTCGTAAAGGAACTCCAGAATGTAGTCAGCCCTGGAAGATTTACTCTAGAAAAACCACAACGCAGAGTCTAAGAGGTG
GCCTCCCAAAGCCAAATAAAGCAGTTCCAATGAAAGTAAGTGAACACAGTCTCCTGCCCCTTATGCTGGAGCAGTTTCCGTTTCTTTATG
TTTCTGGCCCAACACTAAGCAAAATGTGGAAACAGCAAATTGCACAGGTTGAACAGCTTAAGAAAGAAGCATGTAGAGAAAATCGATCAA
AGAAGAAACTCCAAGATGAAATAGAAGAAGCCCTAAGAAGGCATGACCTCCTTACTACCCTTGTCAAGAAAGAATATGAACATAACAAGA
GACTGCAAGACTTCAAGGACTGCATTCGTAGGCAAAGGTTGACCCAATCAAAGATAAAAGAAAATCGACAGCAAATCGTTCGTGCTCGAA
AATATTATGATGATTATAGAGTTCAGTTGTGTGCAAAAATGATGAGAATGAGGACCCGGGAAGAAATGATATTTAAGAAACTGTTTGAAG
AAGGTTTAAACATTCAAAAGCAAAGATTACGAGACCTAAGAAACTATGCCAAAGAAAAGCGAGATGAACAAAGGAGACGCCACCAGGATG
AACTGGACTCCATGGAGAACTACTATAAGGACCAGTTTTCATTGCTGGCAGAAGCCATATCACAGGAACATCAAGAACTTAAAGCCAGAG
AGAAATCTCAGGCCCAGACATTACATAAGGTGAAGAGGGAGCTGAGATCTAAGATGGAGAAGGAAATTCAGCAGCTGCAGGACATGATAA
CACAGAATGATGATGATGTTTTCTTCCGGGAACTGGAAGCTGAGCGCTTCAGATCTCGGCTTCAGCTGGCTTCCTTTCAGTACAGTAAAA
GTCCCTCCCTATGAGGCCAGACTTGATAATAGTAGGTGAAGGTTCTGGAGGCCTTTACCAGGACAGAGCTAGAATCGAGCCAGTAAACAG

>52709_52709_2_MED24-CEP95_MED24_chr17_38209551_ENST00000356271_CEP95_chr17_62517520_ENST00000556440_length(amino acids)=618AA_BP=
MLSKKALASPSSKSHEDMLYPPSVLSKSRTSFVEDTETLSVSGIPNARKLGEPIRAAIPLHPPYHPSEPRAPCPIGKEYLHSSHCSPAVN
STGEHTEFSGDLDDGLFLISKLPKGSKWEVYPAQVQGPRTRKPPKGKRNENRATASSCNSPFPQRPRKRLTEQELHDVSEKLSQRLSELD
WMLKSALGDRIKEKTDHKEENTGNEEVEDGTEETLSQHSDGIVEYGPKKSRPGLSMRRKPPYRSHSLSPSPVNKHKQFHLERKRQRKPRE
TDVRQFQAQAFTEAFERELRRHKVQENIGPLRIHEKEEETEKIYRGEAVRKGTPECSQPWKIYSRKTTTQSLRGGLPKPNKAVPMKVSEH
SLLPLMLEQFPFLYVSGPTLSKMWKQQIAQVEQLKKEACRENRSKKKLQDEIEEALRRHDLLTTLVKKEYEHNKRLQDFKDCIRRQRLTQ
SKIKENRQQIVRARKYYDDYRVQLCAKMMRMRTREEMIFKKLFEEGLNIQKQRLRDLRNYAKEKRDEQRRRHQDELDSMENYYKDQFSLL

--------------------------------------------------------------
>52709_52709_3_MED24-CEP95_MED24_chr17_38209551_ENST00000394126_CEP95_chr17_62521888_ENST00000553412_length(transcript)=2427nt_BP=707nt
GGTGCGATCTCGGCTCACCCCAACAACCTCCGCCTCCCGGGTTCAAGCGATTCTACTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGC
ATGCACCACCAAGCCCGGCTAATTTTGTATTTTTAGTGGAGACGAGGTTTCTCCATGTTGGTCAGGCTAGTCTCGAACTCCTGACCTCCG
GTGATTCGCCCGCCTCTGCCTCCCGAAGTGCTGGGATTACAGGTGCGAGCCACTGCGCTCGGCCGATACTTTCTTAGTGCCCCAGTTTAA
GGAAGGGCGGTTCAGGAGGAGAGAGTCTGACAGGATCTTACTTTATCCCTTTAGCTCTTTTTCTTTCAAATTCCTCTGTCTCGCTTAAAT
CTTCCCGCATCTTCTCCTTTCTATTTAATTCTGCCTTCCCCGGTTCTCCTTAGAACCTCATGTCCTTTTCTTTAGCTCCATTTCTTTCAC
CTCAAAGCTGGCCGCCACCGCTGCCACCTGCTCAGAGTGAAATAATGAAGGTGGTCAACCTGAAGCAAGCCATTTTGCAAGCCTGGAAGG
AGCGCTGGAGTGACTACCAATGGGCAATCAACATGAAGAAATTCTTTCCTAAAGGAGCCACCTGGGATATTCTCAACCTGGCAGATGCGT
TACTAGAGCAGGCCATGATTGGACCATCCCCCAATCCTCTCATCTTGTCCTACCTGAAGTATGCCATTAGTTCCCAGGATCTAGATGATG
GACTTTTCTTAATTTCCAAGTTGCCTAAAGGCAGCAAATGGGAAGTATATCCAGCTCAGGTCCAAGGGCCTAGGACAAGGAAGCCTCCCA
AAGGAAAAAGAAATGAAAACAGAGCTACAGCCTCATCCTGCAATTCACCTTTCCCCCAGAGGCCAAGAAAGAGATTAACAGAACAAGAAT
TACATGATGTATCAGAAAAACTCTCTCAGCGGCTTTCTGAACTAGATTGGATGTTAAAAAGTGCTCTGGGTGATCGGATTAAAGAAAAGA
CTGACCATAAAGAAGAAAATACTGGAAATGAGGAGGTAGAGGATGGAACTGAGGAGACACTGTCTCAGCACAGTGATGGCATCGTGGAGT
ATGGGCCAAAGAAGTCAAGGCCAGGACTTTCCATGCGTAGAAAGCCACCCTACAGATCCCATTCGCTCTCTCCATCTCCAGTTAACAAAC
ACAAACAGTTCCACTTGGAGAGAAAAAGGCAGCGCAAGCCAAGAGAAACAGATGTCCGCCAATTCCAAGCACAGGCGTTTACTGAAGCAT
TTGAAAGGGAACTAAGAAGACATAAAGTTCAAGAGAATATTGGACCTCTAAGAATACATGAGAAGGAGGAGGAAACAGAAAAAATATACA
GAGGAGAAGCTGTTCGTAAAGGAACTCCAGAATGTAGTCAGCCCTGGAAGATTTACTCTAGAAAAACCACAACGCAGAGTCTAAGAGGTG
GCCTCCCAAAGCCAAATAAAGCAGTTCCAATGAAAGTAAGTGAACACAGTCTCCTGCCCCTTATGCTGGAGCAGTTTCCGTTTCTTTATG
TTTCTGGCCCAACACTAAGCAAAATGTGGAAACAGCAAATTGCACAGGTTGAACAGCTTAAGAAAGAAGCATGTAGAGAAAATCGATCAA
AGAAGAAACTCCAAGATGAAATAGAAGAAGCCCTAAGAAGGCATGACCTCCTTACTACCCTTGTCAAGAAAGAATATGAACATAACAAGA
GACTGCAAGACTTCAAGGACTGCATTCGTAGGCAAAGGTTGACCCAATCAAAGATAAAAGAAAATCGACAGCAAATCGTTCGTGCTCGAA
AATATTATGATGATTATAGAGTTCAGTTGTGTGCAAAAATGATGAGAATGAGGACCCGGGAAGAAATGATATTTAAGAAACTGTTTGAAG
AAGGTTTAAACATTCAAAAGCAAAGATTACGAGACCTAAGAAACTATGCCAAAGAAAAGCGAGATGAACAAAGGAGACGCCACCAGGATG
AACTGGACTCCATGGAGAACTACTATAAGGACCAGTTTTCATTGCTGGCAGAAGCCATATCACAGGAACATCAAGAACTTAAAGCCAGAG
AGAAATCTCAGGCCCAGACATTACATAAGGTGAAGAGGGAGCTGAGATCTAAGATGGAGAAGGAAATTCAGCAGCTGCAGGACATGATAA
CACAGAATGATGATGATGTTTTCTTCCGGGAACTGGAAGCTGAGCGCTTCAGATCTCGGCTTCAGCTGGCTTCCTTTCAGTACAGTAAAA
GTCCCTCCCTATGAGGCCAGACTTGATAATAGTAGGTGAAGGTTCTGGAGGCCTTTACCAGGACAGAGCTAGAATCGAGCCAGTAAACAG

>52709_52709_3_MED24-CEP95_MED24_chr17_38209551_ENST00000394126_CEP95_chr17_62521888_ENST00000553412_length(amino acids)=614AA_BP=96
MSFSLAPFLSPQSWPPPLPPAQSEIMKVVNLKQAILQAWKERWSDYQWAINMKKFFPKGATWDILNLADALLEQAMIGPSPNPLILSYLK
YAISSQDLDDGLFLISKLPKGSKWEVYPAQVQGPRTRKPPKGKRNENRATASSCNSPFPQRPRKRLTEQELHDVSEKLSQRLSELDWMLK
SALGDRIKEKTDHKEENTGNEEVEDGTEETLSQHSDGIVEYGPKKSRPGLSMRRKPPYRSHSLSPSPVNKHKQFHLERKRQRKPRETDVR
QFQAQAFTEAFERELRRHKVQENIGPLRIHEKEEETEKIYRGEAVRKGTPECSQPWKIYSRKTTTQSLRGGLPKPNKAVPMKVSEHSLLP
LMLEQFPFLYVSGPTLSKMWKQQIAQVEQLKKEACRENRSKKKLQDEIEEALRRHDLLTTLVKKEYEHNKRLQDFKDCIRRQRLTQSKIK
ENRQQIVRARKYYDDYRVQLCAKMMRMRTREEMIFKKLFEEGLNIQKQRLRDLRNYAKEKRDEQRRRHQDELDSMENYYKDQFSLLAEAI

--------------------------------------------------------------
>52709_52709_4_MED24-CEP95_MED24_chr17_38209551_ENST00000394126_CEP95_chr17_62521888_ENST00000556440_length(transcript)=2427nt_BP=707nt
GGTGCGATCTCGGCTCACCCCAACAACCTCCGCCTCCCGGGTTCAAGCGATTCTACTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGC
ATGCACCACCAAGCCCGGCTAATTTTGTATTTTTAGTGGAGACGAGGTTTCTCCATGTTGGTCAGGCTAGTCTCGAACTCCTGACCTCCG
GTGATTCGCCCGCCTCTGCCTCCCGAAGTGCTGGGATTACAGGTGCGAGCCACTGCGCTCGGCCGATACTTTCTTAGTGCCCCAGTTTAA
GGAAGGGCGGTTCAGGAGGAGAGAGTCTGACAGGATCTTACTTTATCCCTTTAGCTCTTTTTCTTTCAAATTCCTCTGTCTCGCTTAAAT
CTTCCCGCATCTTCTCCTTTCTATTTAATTCTGCCTTCCCCGGTTCTCCTTAGAACCTCATGTCCTTTTCTTTAGCTCCATTTCTTTCAC
CTCAAAGCTGGCCGCCACCGCTGCCACCTGCTCAGAGTGAAATAATGAAGGTGGTCAACCTGAAGCAAGCCATTTTGCAAGCCTGGAAGG
AGCGCTGGAGTGACTACCAATGGGCAATCAACATGAAGAAATTCTTTCCTAAAGGAGCCACCTGGGATATTCTCAACCTGGCAGATGCGT
TACTAGAGCAGGCCATGATTGGACCATCCCCCAATCCTCTCATCTTGTCCTACCTGAAGTATGCCATTAGTTCCCAGGATCTAGATGATG
GACTTTTCTTAATTTCCAAGTTGCCTAAAGGCAGCAAATGGGAAGTATATCCAGCTCAGGTCCAAGGGCCTAGGACAAGGAAGCCTCCCA
AAGGAAAAAGAAATGAAAACAGAGCTACAGCCTCATCCTGCAATTCACCTTTCCCCCAGAGGCCAAGAAAGAGATTAACAGAACAAGAAT
TACATGATGTATCAGAAAAACTCTCTCAGCGGCTTTCTGAACTAGATTGGATGTTAAAAAGTGCTCTGGGTGATCGGATTAAAGAAAAGA
CTGACCATAAAGAAGAAAATACTGGAAATGAGGAGGTAGAGGATGGAACTGAGGAGACACTGTCTCAGCACAGTGATGGCATCGTGGAGT
ATGGGCCAAAGAAGTCAAGGCCAGGACTTTCCATGCGTAGAAAGCCACCCTACAGATCCCATTCGCTCTCTCCATCTCCAGTTAACAAAC
ACAAACAGTTCCACTTGGAGAGAAAAAGGCAGCGCAAGCCAAGAGAAACAGATGTCCGCCAATTCCAAGCACAGGCGTTTACTGAAGCAT
TTGAAAGGGAACTAAGAAGACATAAAGTTCAAGAGAATATTGGACCTCTAAGAATACATGAGAAGGAGGAGGAAACAGAAAAAATATACA
GAGGAGAAGCTGTTCGTAAAGGAACTCCAGAATGTAGTCAGCCCTGGAAGATTTACTCTAGAAAAACCACAACGCAGAGTCTAAGAGGTG
GCCTCCCAAAGCCAAATAAAGCAGTTCCAATGAAAGTAAGTGAACACAGTCTCCTGCCCCTTATGCTGGAGCAGTTTCCGTTTCTTTATG
TTTCTGGCCCAACACTAAGCAAAATGTGGAAACAGCAAATTGCACAGGTTGAACAGCTTAAGAAAGAAGCATGTAGAGAAAATCGATCAA
AGAAGAAACTCCAAGATGAAATAGAAGAAGCCCTAAGAAGGCATGACCTCCTTACTACCCTTGTCAAGAAAGAATATGAACATAACAAGA
GACTGCAAGACTTCAAGGACTGCATTCGTAGGCAAAGGTTGACCCAATCAAAGATAAAAGAAAATCGACAGCAAATCGTTCGTGCTCGAA
AATATTATGATGATTATAGAGTTCAGTTGTGTGCAAAAATGATGAGAATGAGGACCCGGGAAGAAATGATATTTAAGAAACTGTTTGAAG
AAGGTTTAAACATTCAAAAGCAAAGATTACGAGACCTAAGAAACTATGCCAAAGAAAAGCGAGATGAACAAAGGAGACGCCACCAGGATG
AACTGGACTCCATGGAGAACTACTATAAGGACCAGTTTTCATTGCTGGCAGAAGCCATATCACAGGAACATCAAGAACTTAAAGCCAGAG
AGAAATCTCAGGCCCAGACATTACATAAGGTGAAGAGGGAGCTGAGATCTAAGATGGAGAAGGAAATTCAGCAGCTGCAGGACATGATAA
CACAGAATGATGATGATGTTTTCTTCCGGGAACTGGAAGCTGAGCGCTTCAGATCTCGGCTTCAGCTGGCTTCCTTTCAGTACAGTAAAA
GTCCCTCCCTATGAGGCCAGACTTGATAATAGTAGGTGAAGGTTCTGGAGGCCTTTACCAGGACAGAGCTAGAATCGAGCCAGTAAACAG

>52709_52709_4_MED24-CEP95_MED24_chr17_38209551_ENST00000394126_CEP95_chr17_62521888_ENST00000556440_length(amino acids)=614AA_BP=96
MSFSLAPFLSPQSWPPPLPPAQSEIMKVVNLKQAILQAWKERWSDYQWAINMKKFFPKGATWDILNLADALLEQAMIGPSPNPLILSYLK
YAISSQDLDDGLFLISKLPKGSKWEVYPAQVQGPRTRKPPKGKRNENRATASSCNSPFPQRPRKRLTEQELHDVSEKLSQRLSELDWMLK
SALGDRIKEKTDHKEENTGNEEVEDGTEETLSQHSDGIVEYGPKKSRPGLSMRRKPPYRSHSLSPSPVNKHKQFHLERKRQRKPRETDVR
QFQAQAFTEAFERELRRHKVQENIGPLRIHEKEEETEKIYRGEAVRKGTPECSQPWKIYSRKTTTQSLRGGLPKPNKAVPMKVSEHSLLP
LMLEQFPFLYVSGPTLSKMWKQQIAQVEQLKKEACRENRSKKKLQDEIEEALRRHDLLTTLVKKEYEHNKRLQDFKDCIRRQRLTQSKIK
ENRQQIVRARKYYDDYRVQLCAKMMRMRTREEMIFKKLFEEGLNIQKQRLRDLRNYAKEKRDEQRRRHQDELDSMENYYKDQFSLLAEAI

--------------------------------------------------------------
>52709_52709_5_MED24-CEP95_MED24_chr17_38209551_ENST00000394128_CEP95_chr17_62517520_ENST00000553412_length(transcript)=2335nt_BP=295nt
AAGTGCCAAAATGGCGATGCCTACCACCTAGAACTGGATTGTGCGCTGGCCGCCACCGCTGCCACCTGCTCAGAGTGAAATAATGAAGGT
GGTCAACCTGAAGCAAGCCATTTTGCAAGCCTGGAAGGAGCGCTGGAGTGACTACCAATGGGCAATCAACATGAAGAAATTCTTTCCTAA
AGGAGCCACCTGGGATATTCTCAACCTGGCAGATGCGTTACTAGAGCAGGCCATGATTGGACCATCCCCCAATCCTCTCATCTTGTCCTA
CCTGAAGTATGCCATTAGTTCCCAGGTGCTCAATGTCCTAATGAAATGCTGTCTAAAAAAGCCTTAGCCTCACCAAGTTCTAAATCACAT
GAAGATATGTTGTACCCTCCTAGTGTTTTGTCCAAGAGTAGGACATCCTTTGTTGAAGACACGGAAACCCTTTCTGTGAGTGGGATTCCA
AATGCTAGGAAGCTAGGGGAGCCTATCCGAGCAGCTATTCCTTTACATCCACCCTACCACCCTTCAGAGCCTCGAGCACCCTGCCCCATA
GGAAAAGAATACTTGCATTCAAGTCACTGCTCCCCAGCCGTAAATTCTACTGGAGAGCATACGGAATTTTCTGGGGATCTAGATGATGGA
CTTTTCTTAATTTCCAAGTTGCCTAAAGGCAGCAAATGGGAAGTATATCCAGCTCAGGTCCAAGGGCCTAGGACAAGGAAGCCTCCCAAA
GGAAAAAGAAATGAAAACAGAGCTACAGCCTCATCCTGCAATTCACCTTTCCCCCAGAGGCCAAGAAAGAGATTAACAGAACAAGAATTA
CATGATGTATCAGAAAAACTCTCTCAGCGGCTTTCTGAACTAGATTGGATGTTAAAAAGTGCTCTGGGTGATCGGATTAAAGAAAAGACT
GACCATAAAGAAGAAAATACTGGAAATGAGGAGGTAGAGGATGGAACTGAGGAGACACTGTCTCAGCACAGTGATGGCATCGTGGAGTAT
GGGCCAAAGAAGTCAAGGCCAGGACTTTCCATGCGTAGAAAGCCACCCTACAGATCCCATTCGCTCTCTCCATCTCCAGTTAACAAACAC
AAACAGTTCCACTTGGAGAGAAAAAGGCAGCGCAAGCCAAGAGAAACAGATGTCCGCCAATTCCAAGCACAGGCGTTTACTGAAGCATTT
GAAAGGGAACTAAGAAGACATAAAGTTCAAGAGAATATTGGACCTCTAAGAATACATGAGAAGGAGGAGGAAACAGAAAAAATATACAGA
GGAGAAGCTGTTCGTAAAGGAACTCCAGAATGTAGTCAGCCCTGGAAGATTTACTCTAGAAAAACCACAACGCAGAGTCTAAGAGGTGGC
CTCCCAAAGCCAAATAAAGCAGTTCCAATGAAAGTAAGTGAACACAGTCTCCTGCCCCTTATGCTGGAGCAGTTTCCGTTTCTTTATGTT
TCTGGCCCAACACTAAGCAAAATGTGGAAACAGCAAATTGCACAGGTTGAACAGCTTAAGAAAGAAGCATGTAGAGAAAATCGATCAAAG
AAGAAACTCCAAGATGAAATAGAAGAAGCCCTAAGAAGGCATGACCTCCTTACTACCCTTGTCAAGAAAGAATATGAACATAACAAGAGA
CTGCAAGACTTCAAGGACTGCATTCGTAGGCAAAGGTTGACCCAATCAAAGATAAAAGAAAATCGACAGCAAATCGTTCGTGCTCGAAAA
TATTATGATGATTATAGAGTTCAGTTGTGTGCAAAAATGATGAGAATGAGGACCCGGGAAGAAATGATATTTAAGAAACTGTTTGAAGAA
GGTTTAAACATTCAAAAGCAAAGATTACGAGACCTAAGAAACTATGCCAAAGAAAAGCGAGATGAACAAAGGAGACGCCACCAGGATGAA
CTGGACTCCATGGAGAACTACTATAAGGACCAGTTTTCATTGCTGGCAGAAGCCATATCACAGGAACATCAAGAACTTAAAGCCAGAGAG
AAATCTCAGGCCCAGACATTACATAAGGTGAAGAGGGAGCTGAGATCTAAGATGGAGAAGGAAATTCAGCAGCTGCAGGACATGATAACA
CAGAATGATGATGATGTTTTCTTCCGGGAACTGGAAGCTGAGCGCTTCAGATCTCGGCTTCAGCTGGCTTCCTTTCAGTACAGTAAAAGT
CCCTCCCTATGAGGCCAGACTTGATAATAGTAGGTGAAGGTTCTGGAGGCCTTTACCAGGACAGAGCTAGAATCGAGCCAGTAAACAGTC

>52709_52709_5_MED24-CEP95_MED24_chr17_38209551_ENST00000394128_CEP95_chr17_62517520_ENST00000553412_length(amino acids)=618AA_BP=
MLSKKALASPSSKSHEDMLYPPSVLSKSRTSFVEDTETLSVSGIPNARKLGEPIRAAIPLHPPYHPSEPRAPCPIGKEYLHSSHCSPAVN
STGEHTEFSGDLDDGLFLISKLPKGSKWEVYPAQVQGPRTRKPPKGKRNENRATASSCNSPFPQRPRKRLTEQELHDVSEKLSQRLSELD
WMLKSALGDRIKEKTDHKEENTGNEEVEDGTEETLSQHSDGIVEYGPKKSRPGLSMRRKPPYRSHSLSPSPVNKHKQFHLERKRQRKPRE
TDVRQFQAQAFTEAFERELRRHKVQENIGPLRIHEKEEETEKIYRGEAVRKGTPECSQPWKIYSRKTTTQSLRGGLPKPNKAVPMKVSEH
SLLPLMLEQFPFLYVSGPTLSKMWKQQIAQVEQLKKEACRENRSKKKLQDEIEEALRRHDLLTTLVKKEYEHNKRLQDFKDCIRRQRLTQ
SKIKENRQQIVRARKYYDDYRVQLCAKMMRMRTREEMIFKKLFEEGLNIQKQRLRDLRNYAKEKRDEQRRRHQDELDSMENYYKDQFSLL

--------------------------------------------------------------
>52709_52709_6_MED24-CEP95_MED24_chr17_38209551_ENST00000394128_CEP95_chr17_62517520_ENST00000556440_length(transcript)=2335nt_BP=295nt
AAGTGCCAAAATGGCGATGCCTACCACCTAGAACTGGATTGTGCGCTGGCCGCCACCGCTGCCACCTGCTCAGAGTGAAATAATGAAGGT
GGTCAACCTGAAGCAAGCCATTTTGCAAGCCTGGAAGGAGCGCTGGAGTGACTACCAATGGGCAATCAACATGAAGAAATTCTTTCCTAA
AGGAGCCACCTGGGATATTCTCAACCTGGCAGATGCGTTACTAGAGCAGGCCATGATTGGACCATCCCCCAATCCTCTCATCTTGTCCTA
CCTGAAGTATGCCATTAGTTCCCAGGTGCTCAATGTCCTAATGAAATGCTGTCTAAAAAAGCCTTAGCCTCACCAAGTTCTAAATCACAT
GAAGATATGTTGTACCCTCCTAGTGTTTTGTCCAAGAGTAGGACATCCTTTGTTGAAGACACGGAAACCCTTTCTGTGAGTGGGATTCCA
AATGCTAGGAAGCTAGGGGAGCCTATCCGAGCAGCTATTCCTTTACATCCACCCTACCACCCTTCAGAGCCTCGAGCACCCTGCCCCATA
GGAAAAGAATACTTGCATTCAAGTCACTGCTCCCCAGCCGTAAATTCTACTGGAGAGCATACGGAATTTTCTGGGGATCTAGATGATGGA
CTTTTCTTAATTTCCAAGTTGCCTAAAGGCAGCAAATGGGAAGTATATCCAGCTCAGGTCCAAGGGCCTAGGACAAGGAAGCCTCCCAAA
GGAAAAAGAAATGAAAACAGAGCTACAGCCTCATCCTGCAATTCACCTTTCCCCCAGAGGCCAAGAAAGAGATTAACAGAACAAGAATTA
CATGATGTATCAGAAAAACTCTCTCAGCGGCTTTCTGAACTAGATTGGATGTTAAAAAGTGCTCTGGGTGATCGGATTAAAGAAAAGACT
GACCATAAAGAAGAAAATACTGGAAATGAGGAGGTAGAGGATGGAACTGAGGAGACACTGTCTCAGCACAGTGATGGCATCGTGGAGTAT
GGGCCAAAGAAGTCAAGGCCAGGACTTTCCATGCGTAGAAAGCCACCCTACAGATCCCATTCGCTCTCTCCATCTCCAGTTAACAAACAC
AAACAGTTCCACTTGGAGAGAAAAAGGCAGCGCAAGCCAAGAGAAACAGATGTCCGCCAATTCCAAGCACAGGCGTTTACTGAAGCATTT
GAAAGGGAACTAAGAAGACATAAAGTTCAAGAGAATATTGGACCTCTAAGAATACATGAGAAGGAGGAGGAAACAGAAAAAATATACAGA
GGAGAAGCTGTTCGTAAAGGAACTCCAGAATGTAGTCAGCCCTGGAAGATTTACTCTAGAAAAACCACAACGCAGAGTCTAAGAGGTGGC
CTCCCAAAGCCAAATAAAGCAGTTCCAATGAAAGTAAGTGAACACAGTCTCCTGCCCCTTATGCTGGAGCAGTTTCCGTTTCTTTATGTT
TCTGGCCCAACACTAAGCAAAATGTGGAAACAGCAAATTGCACAGGTTGAACAGCTTAAGAAAGAAGCATGTAGAGAAAATCGATCAAAG
AAGAAACTCCAAGATGAAATAGAAGAAGCCCTAAGAAGGCATGACCTCCTTACTACCCTTGTCAAGAAAGAATATGAACATAACAAGAGA
CTGCAAGACTTCAAGGACTGCATTCGTAGGCAAAGGTTGACCCAATCAAAGATAAAAGAAAATCGACAGCAAATCGTTCGTGCTCGAAAA
TATTATGATGATTATAGAGTTCAGTTGTGTGCAAAAATGATGAGAATGAGGACCCGGGAAGAAATGATATTTAAGAAACTGTTTGAAGAA
GGTTTAAACATTCAAAAGCAAAGATTACGAGACCTAAGAAACTATGCCAAAGAAAAGCGAGATGAACAAAGGAGACGCCACCAGGATGAA
CTGGACTCCATGGAGAACTACTATAAGGACCAGTTTTCATTGCTGGCAGAAGCCATATCACAGGAACATCAAGAACTTAAAGCCAGAGAG
AAATCTCAGGCCCAGACATTACATAAGGTGAAGAGGGAGCTGAGATCTAAGATGGAGAAGGAAATTCAGCAGCTGCAGGACATGATAACA
CAGAATGATGATGATGTTTTCTTCCGGGAACTGGAAGCTGAGCGCTTCAGATCTCGGCTTCAGCTGGCTTCCTTTCAGTACAGTAAAAGT
CCCTCCCTATGAGGCCAGACTTGATAATAGTAGGTGAAGGTTCTGGAGGCCTTTACCAGGACAGAGCTAGAATCGAGCCAGTAAACAGTC

>52709_52709_6_MED24-CEP95_MED24_chr17_38209551_ENST00000394128_CEP95_chr17_62517520_ENST00000556440_length(amino acids)=618AA_BP=
MLSKKALASPSSKSHEDMLYPPSVLSKSRTSFVEDTETLSVSGIPNARKLGEPIRAAIPLHPPYHPSEPRAPCPIGKEYLHSSHCSPAVN
STGEHTEFSGDLDDGLFLISKLPKGSKWEVYPAQVQGPRTRKPPKGKRNENRATASSCNSPFPQRPRKRLTEQELHDVSEKLSQRLSELD
WMLKSALGDRIKEKTDHKEENTGNEEVEDGTEETLSQHSDGIVEYGPKKSRPGLSMRRKPPYRSHSLSPSPVNKHKQFHLERKRQRKPRE
TDVRQFQAQAFTEAFERELRRHKVQENIGPLRIHEKEEETEKIYRGEAVRKGTPECSQPWKIYSRKTTTQSLRGGLPKPNKAVPMKVSEH
SLLPLMLEQFPFLYVSGPTLSKMWKQQIAQVEQLKKEACRENRSKKKLQDEIEEALRRHDLLTTLVKKEYEHNKRLQDFKDCIRRQRLTQ
SKIKENRQQIVRARKYYDDYRVQLCAKMMRMRTREEMIFKKLFEEGLNIQKQRLRDLRNYAKEKRDEQRRRHQDELDSMENYYKDQFSLL

--------------------------------------------------------------
>52709_52709_7_MED24-CEP95_MED24_chr17_38209551_ENST00000501516_CEP95_chr17_62521888_ENST00000553412_length(transcript)=1943nt_BP=223nt
GAGTGAAATAATGAAGGTGGTCAACCTGAAGCAAGCCATTTTGCAAGCCTGGAAGGAGCGCTGGAGTGACTACCAATGGGCAATCAACAT
GAAGAAATTCTTTCCTAAAGGAGCCACCTGGGATATTCTCAACCTGGCAGATGCGTTACTAGAGCAGGCCATGATTGGACCATCCCCCAA
TCCTCTCATCTTGTCCTACCTGAAGTATGCCATTAGTTCCCAGGATCTAGATGATGGACTTTTCTTAATTTCCAAGTTGCCTAAAGGCAG
CAAATGGGAAGTATATCCAGCTCAGGTCCAAGGGCCTAGGACAAGGAAGCCTCCCAAAGGAAAAAGAAATGAAAACAGAGCTACAGCCTC
ATCCTGCAATTCACCTTTCCCCCAGAGGCCAAGAAAGAGATTAACAGAACAAGAATTACATGATGTATCAGAAAAACTCTCTCAGCGGCT
TTCTGAACTAGATTGGATGTTAAAAAGTGCTCTGGGTGATCGGATTAAAGAAAAGACTGACCATAAAGAAGAAAATACTGGAAATGAGGA
GGTAGAGGATGGAACTGAGGAGACACTGTCTCAGCACAGTGATGGCATCGTGGAGTATGGGCCAAAGAAGTCAAGGCCAGGACTTTCCAT
GCGTAGAAAGCCACCCTACAGATCCCATTCGCTCTCTCCATCTCCAGTTAACAAACACAAACAGTTCCACTTGGAGAGAAAAAGGCAGCG
CAAGCCAAGAGAAACAGATGTCCGCCAATTCCAAGCACAGGCGTTTACTGAAGCATTTGAAAGGGAACTAAGAAGACATAAAGTTCAAGA
GAATATTGGACCTCTAAGAATACATGAGAAGGAGGAGGAAACAGAAAAAATATACAGAGGAGAAGCTGTTCGTAAAGGAACTCCAGAATG
TAGTCAGCCCTGGAAGATTTACTCTAGAAAAACCACAACGCAGAGTCTAAGAGGTGGCCTCCCAAAGCCAAATAAAGCAGTTCCAATGAA
AGTAAGTGAACACAGTCTCCTGCCCCTTATGCTGGAGCAGTTTCCGTTTCTTTATGTTTCTGGCCCAACACTAAGCAAAATGTGGAAACA
GCAAATTGCACAGGTTGAACAGCTTAAGAAAGAAGCATGTAGAGAAAATCGATCAAAGAAGAAACTCCAAGATGAAATAGAAGAAGCCCT
AAGAAGGCATGACCTCCTTACTACCCTTGTCAAGAAAGAATATGAACATAACAAGAGACTGCAAGACTTCAAGGACTGCATTCGTAGGCA
AAGGTTGACCCAATCAAAGATAAAAGAAAATCGACAGCAAATCGTTCGTGCTCGAAAATATTATGATGATTATAGAGTTCAGTTGTGTGC
AAAAATGATGAGAATGAGGACCCGGGAAGAAATGATATTTAAGAAACTGTTTGAAGAAGGTTTAAACATTCAAAAGCAAAGATTACGAGA
CCTAAGAAACTATGCCAAAGAAAAGCGAGATGAACAAAGGAGACGCCACCAGGATGAACTGGACTCCATGGAGAACTACTATAAGGACCA
GTTTTCATTGCTGGCAGAAGCCATATCACAGGAACATCAAGAACTTAAAGCCAGAGAGAAATCTCAGGCCCAGACATTACATAAGGTGAA
GAGGGAGCTGAGATCTAAGATGGAGAAGGAAATTCAGCAGCTGCAGGACATGATAACACAGAATGATGATGATGTTTTCTTCCGGGAACT
GGAAGCTGAGCGCTTCAGATCTCGGCTTCAGCTGGCTTCCTTTCAGTACAGTAAAAGTCCCTCCCTATGAGGCCAGACTTGATAATAGTA
GGTGAAGGTTCTGGAGGCCTTTACCAGGACAGAGCTAGAATCGAGCCAGTAAACAGTCTAAGCCAGAAAAATAATTTTCAAATGCTTTAC

>52709_52709_7_MED24-CEP95_MED24_chr17_38209551_ENST00000501516_CEP95_chr17_62521888_ENST00000553412_length(amino acids)=589AA_BP=71
MKVVNLKQAILQAWKERWSDYQWAINMKKFFPKGATWDILNLADALLEQAMIGPSPNPLILSYLKYAISSQDLDDGLFLISKLPKGSKWE
VYPAQVQGPRTRKPPKGKRNENRATASSCNSPFPQRPRKRLTEQELHDVSEKLSQRLSELDWMLKSALGDRIKEKTDHKEENTGNEEVED
GTEETLSQHSDGIVEYGPKKSRPGLSMRRKPPYRSHSLSPSPVNKHKQFHLERKRQRKPRETDVRQFQAQAFTEAFERELRRHKVQENIG
PLRIHEKEEETEKIYRGEAVRKGTPECSQPWKIYSRKTTTQSLRGGLPKPNKAVPMKVSEHSLLPLMLEQFPFLYVSGPTLSKMWKQQIA
QVEQLKKEACRENRSKKKLQDEIEEALRRHDLLTTLVKKEYEHNKRLQDFKDCIRRQRLTQSKIKENRQQIVRARKYYDDYRVQLCAKMM
RMRTREEMIFKKLFEEGLNIQKQRLRDLRNYAKEKRDEQRRRHQDELDSMENYYKDQFSLLAEAISQEHQELKAREKSQAQTLHKVKREL

--------------------------------------------------------------
>52709_52709_8_MED24-CEP95_MED24_chr17_38209551_ENST00000501516_CEP95_chr17_62521888_ENST00000556440_length(transcript)=1943nt_BP=223nt
GAGTGAAATAATGAAGGTGGTCAACCTGAAGCAAGCCATTTTGCAAGCCTGGAAGGAGCGCTGGAGTGACTACCAATGGGCAATCAACAT
GAAGAAATTCTTTCCTAAAGGAGCCACCTGGGATATTCTCAACCTGGCAGATGCGTTACTAGAGCAGGCCATGATTGGACCATCCCCCAA
TCCTCTCATCTTGTCCTACCTGAAGTATGCCATTAGTTCCCAGGATCTAGATGATGGACTTTTCTTAATTTCCAAGTTGCCTAAAGGCAG
CAAATGGGAAGTATATCCAGCTCAGGTCCAAGGGCCTAGGACAAGGAAGCCTCCCAAAGGAAAAAGAAATGAAAACAGAGCTACAGCCTC
ATCCTGCAATTCACCTTTCCCCCAGAGGCCAAGAAAGAGATTAACAGAACAAGAATTACATGATGTATCAGAAAAACTCTCTCAGCGGCT
TTCTGAACTAGATTGGATGTTAAAAAGTGCTCTGGGTGATCGGATTAAAGAAAAGACTGACCATAAAGAAGAAAATACTGGAAATGAGGA
GGTAGAGGATGGAACTGAGGAGACACTGTCTCAGCACAGTGATGGCATCGTGGAGTATGGGCCAAAGAAGTCAAGGCCAGGACTTTCCAT
GCGTAGAAAGCCACCCTACAGATCCCATTCGCTCTCTCCATCTCCAGTTAACAAACACAAACAGTTCCACTTGGAGAGAAAAAGGCAGCG
CAAGCCAAGAGAAACAGATGTCCGCCAATTCCAAGCACAGGCGTTTACTGAAGCATTTGAAAGGGAACTAAGAAGACATAAAGTTCAAGA
GAATATTGGACCTCTAAGAATACATGAGAAGGAGGAGGAAACAGAAAAAATATACAGAGGAGAAGCTGTTCGTAAAGGAACTCCAGAATG
TAGTCAGCCCTGGAAGATTTACTCTAGAAAAACCACAACGCAGAGTCTAAGAGGTGGCCTCCCAAAGCCAAATAAAGCAGTTCCAATGAA
AGTAAGTGAACACAGTCTCCTGCCCCTTATGCTGGAGCAGTTTCCGTTTCTTTATGTTTCTGGCCCAACACTAAGCAAAATGTGGAAACA
GCAAATTGCACAGGTTGAACAGCTTAAGAAAGAAGCATGTAGAGAAAATCGATCAAAGAAGAAACTCCAAGATGAAATAGAAGAAGCCCT
AAGAAGGCATGACCTCCTTACTACCCTTGTCAAGAAAGAATATGAACATAACAAGAGACTGCAAGACTTCAAGGACTGCATTCGTAGGCA
AAGGTTGACCCAATCAAAGATAAAAGAAAATCGACAGCAAATCGTTCGTGCTCGAAAATATTATGATGATTATAGAGTTCAGTTGTGTGC
AAAAATGATGAGAATGAGGACCCGGGAAGAAATGATATTTAAGAAACTGTTTGAAGAAGGTTTAAACATTCAAAAGCAAAGATTACGAGA
CCTAAGAAACTATGCCAAAGAAAAGCGAGATGAACAAAGGAGACGCCACCAGGATGAACTGGACTCCATGGAGAACTACTATAAGGACCA
GTTTTCATTGCTGGCAGAAGCCATATCACAGGAACATCAAGAACTTAAAGCCAGAGAGAAATCTCAGGCCCAGACATTACATAAGGTGAA
GAGGGAGCTGAGATCTAAGATGGAGAAGGAAATTCAGCAGCTGCAGGACATGATAACACAGAATGATGATGATGTTTTCTTCCGGGAACT
GGAAGCTGAGCGCTTCAGATCTCGGCTTCAGCTGGCTTCCTTTCAGTACAGTAAAAGTCCCTCCCTATGAGGCCAGACTTGATAATAGTA
GGTGAAGGTTCTGGAGGCCTTTACCAGGACAGAGCTAGAATCGAGCCAGTAAACAGTCTAAGCCAGAAAAATAATTTTCAAATGCTTTAC

>52709_52709_8_MED24-CEP95_MED24_chr17_38209551_ENST00000501516_CEP95_chr17_62521888_ENST00000556440_length(amino acids)=589AA_BP=71
MKVVNLKQAILQAWKERWSDYQWAINMKKFFPKGATWDILNLADALLEQAMIGPSPNPLILSYLKYAISSQDLDDGLFLISKLPKGSKWE
VYPAQVQGPRTRKPPKGKRNENRATASSCNSPFPQRPRKRLTEQELHDVSEKLSQRLSELDWMLKSALGDRIKEKTDHKEENTGNEEVED
GTEETLSQHSDGIVEYGPKKSRPGLSMRRKPPYRSHSLSPSPVNKHKQFHLERKRQRKPRETDVRQFQAQAFTEAFERELRRHKVQENIG
PLRIHEKEEETEKIYRGEAVRKGTPECSQPWKIYSRKTTTQSLRGGLPKPNKAVPMKVSEHSLLPLMLEQFPFLYVSGPTLSKMWKQQIA
QVEQLKKEACRENRSKKKLQDEIEEALRRHDLLTTLVKKEYEHNKRLQDFKDCIRRQRLTQSKIKENRQQIVRARKYYDDYRVQLCAKMM
RMRTREEMIFKKLFEEGLNIQKQRLRDLRNYAKEKRDEQRRRHQDELDSMENYYKDQFSLLAEAISQEHQELKAREKSQAQTLHKVKREL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MED24-CEP95


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for MED24-CEP95


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for MED24-CEP95


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource