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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MED24-IKZF3 (FusionGDB2 ID:52712)

Fusion Gene Summary for MED24-IKZF3

check button Fusion gene summary
Fusion gene informationFusion gene name: MED24-IKZF3
Fusion gene ID: 52712
HgeneTgene
Gene symbol

MED24

IKZF3

Gene ID

9862

22806

Gene namemediator complex subunit 24IKAROS family zinc finger 3
SynonymsARC100|CRSP100|CRSP4|DRIP100|MED5|THRAP4|TRAP100AIO|AIOLOS|ZNFN1A3
Cytomap

17q21.1

17q12-q21.1

Type of geneprotein-codingprotein-coding
Descriptionmediator of RNA polymerase II transcription subunit 24CRSP complex subunit 4activator-recruited cofactor 100 kDa componentcofactor required for Sp1 transcriptional activation subunit 4cofactor required for Sp1 transcriptional activation, subunit 4, 10zinc finger protein Aioloszinc finger DNA binding protein Aioloszinc finger protein, subfamily 1A, 3 (Aiolos)
Modification date2020031320200327
UniProtAcc

O75448

Q9UKT9

Ensembl transtripts involved in fusion geneENST00000356271, ENST00000394126, 
ENST00000394127, ENST00000394128, 
ENST00000501516, ENST00000479829, 
ENST00000346243, ENST00000350532, 
ENST00000351680, ENST00000377944, 
ENST00000377945, ENST00000377952, 
ENST00000377958, ENST00000394189, 
ENST00000439016, ENST00000439167, 
ENST00000467757, ENST00000535189, 
ENST00000583368, ENST00000346872, 
Fusion gene scores* DoF score21 X 18 X 9=340234 X 12 X 14=5712
# samples 2649
** MAII scorelog2(26/3402*10)=-3.70979961263493
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(49/5712*10)=-3.54314232502653
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MED24 [Title/Abstract] AND IKZF3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIKZF3(37985640)-MED24(38176186), # samples:2
MED24(38176526)-IKZF3(37949186), # samples:2
Anticipated loss of major functional domain due to fusion event.MED24-IKZF3 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
MED24-IKZF3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
MED24-IKZF3 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
MED24-IKZF3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
MED24-IKZF3 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
MED24-IKZF3 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMED24

GO:0006367

transcription initiation from RNA polymerase II promoter

12218053

HgeneMED24

GO:0045893

positive regulation of transcription, DNA-templated

10198638


check buttonFusion gene breakpoints across MED24 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across IKZF3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A14P-01AMED24chr17

38176526

-IKZF3chr17

37949186

-


Top

Fusion Gene ORF analysis for MED24-IKZF3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000356271ENST00000346243MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000356271ENST00000350532MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000356271ENST00000351680MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000356271ENST00000377944MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000356271ENST00000377945MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000356271ENST00000377952MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000356271ENST00000377958MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000356271ENST00000394189MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000356271ENST00000439016MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000356271ENST00000439167MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000356271ENST00000467757MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000356271ENST00000535189MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000356271ENST00000583368MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000394126ENST00000346243MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000394126ENST00000350532MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000394126ENST00000351680MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000394126ENST00000377944MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000394126ENST00000377945MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000394126ENST00000377952MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000394126ENST00000377958MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000394126ENST00000394189MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000394126ENST00000439016MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000394126ENST00000439167MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000394126ENST00000467757MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000394126ENST00000535189MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000394126ENST00000583368MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000394127ENST00000346243MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000394127ENST00000350532MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000394127ENST00000351680MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000394127ENST00000377944MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000394127ENST00000377945MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000394127ENST00000377952MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000394127ENST00000377958MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000394127ENST00000394189MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000394127ENST00000439016MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000394127ENST00000439167MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000394127ENST00000467757MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000394127ENST00000535189MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000394127ENST00000583368MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000394128ENST00000346243MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000394128ENST00000350532MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000394128ENST00000351680MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000394128ENST00000377944MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000394128ENST00000377945MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000394128ENST00000377952MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000394128ENST00000377958MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000394128ENST00000394189MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000394128ENST00000439016MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000394128ENST00000439167MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000394128ENST00000467757MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000394128ENST00000535189MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000394128ENST00000583368MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000501516ENST00000346243MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000501516ENST00000350532MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000501516ENST00000351680MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000501516ENST00000377944MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000501516ENST00000377945MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000501516ENST00000377952MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000501516ENST00000377958MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000501516ENST00000394189MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000501516ENST00000439016MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000501516ENST00000439167MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000501516ENST00000467757MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000501516ENST00000535189MED24chr17

38176526

-IKZF3chr17

37949186

-
5CDS-intronENST00000501516ENST00000583368MED24chr17

38176526

-IKZF3chr17

37949186

-
Frame-shiftENST00000356271ENST00000346872MED24chr17

38176526

-IKZF3chr17

37949186

-
Frame-shiftENST00000394127ENST00000346872MED24chr17

38176526

-IKZF3chr17

37949186

-
Frame-shiftENST00000394128ENST00000346872MED24chr17

38176526

-IKZF3chr17

37949186

-
In-frameENST00000394126ENST00000346872MED24chr17

38176526

-IKZF3chr17

37949186

-
In-frameENST00000501516ENST00000346872MED24chr17

38176526

-IKZF3chr17

37949186

-
intron-3CDSENST00000479829ENST00000346872MED24chr17

38176526

-IKZF3chr17

37949186

-
intron-intronENST00000479829ENST00000346243MED24chr17

38176526

-IKZF3chr17

37949186

-
intron-intronENST00000479829ENST00000350532MED24chr17

38176526

-IKZF3chr17

37949186

-
intron-intronENST00000479829ENST00000351680MED24chr17

38176526

-IKZF3chr17

37949186

-
intron-intronENST00000479829ENST00000377944MED24chr17

38176526

-IKZF3chr17

37949186

-
intron-intronENST00000479829ENST00000377945MED24chr17

38176526

-IKZF3chr17

37949186

-
intron-intronENST00000479829ENST00000377952MED24chr17

38176526

-IKZF3chr17

37949186

-
intron-intronENST00000479829ENST00000377958MED24chr17

38176526

-IKZF3chr17

37949186

-
intron-intronENST00000479829ENST00000394189MED24chr17

38176526

-IKZF3chr17

37949186

-
intron-intronENST00000479829ENST00000439016MED24chr17

38176526

-IKZF3chr17

37949186

-
intron-intronENST00000479829ENST00000439167MED24chr17

38176526

-IKZF3chr17

37949186

-
intron-intronENST00000479829ENST00000467757MED24chr17

38176526

-IKZF3chr17

37949186

-
intron-intronENST00000479829ENST00000535189MED24chr17

38176526

-IKZF3chr17

37949186

-
intron-intronENST00000479829ENST00000583368MED24chr17

38176526

-IKZF3chr17

37949186

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000394126MED24chr1738176526-ENST00000346872IKZF3chr1737949186-5410319841945641381
ENST00000501516MED24chr1738176526-ENST00000346872IKZF3chr1737949186-498327711041371375

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000394126ENST00000346872MED24chr1738176526-IKZF3chr1737949186-0.0019927910.99800724
ENST00000501516ENST00000346872MED24chr1738176526-IKZF3chr1737949186-0.0015040570.99849594

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Fusion Genomic Features for MED24-IKZF3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MED24-IKZF3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:37985640/chr17:38176186)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MED24

O75448

IKZF3

Q9UKT9

FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:16595664}.FUNCTION: Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner. {ECO:0000269|PubMed:10369681}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMED24chr17:38176526chr17:37949186ENST00000356271-2325128_132888977.0MotifNote=LXXLL motif 1
HgeneMED24chr17:38176526chr17:37949186ENST00000356271-2325344_348888977.0MotifNote=LXXLL motif 2
HgeneMED24chr17:38176526chr17:37949186ENST00000356271-2325448_452888977.0MotifNote=LXXLL motif 3
HgeneMED24chr17:38176526chr17:37949186ENST00000356271-2325557_561888977.0MotifNote=LXXLL motif 4
HgeneMED24chr17:38176526chr17:37949186ENST00000356271-2325788_792888977.0MotifNote=LXXLL motif 5
HgeneMED24chr17:38176526chr17:37949186ENST00000356271-2325857_861888977.0MotifNote=LXXLL motif 6
HgeneMED24chr17:38176526chr17:37949186ENST00000394127-2325128_132888977.0MotifNote=LXXLL motif 1
HgeneMED24chr17:38176526chr17:37949186ENST00000394127-2325344_348888977.0MotifNote=LXXLL motif 2
HgeneMED24chr17:38176526chr17:37949186ENST00000394127-2325448_452888977.0MotifNote=LXXLL motif 3
HgeneMED24chr17:38176526chr17:37949186ENST00000394127-2325557_561888977.0MotifNote=LXXLL motif 4
HgeneMED24chr17:38176526chr17:37949186ENST00000394127-2325788_792888977.0MotifNote=LXXLL motif 5
HgeneMED24chr17:38176526chr17:37949186ENST00000394127-2325857_861888977.0MotifNote=LXXLL motif 6
HgeneMED24chr17:38176526chr17:37949186ENST00000394128-2426128_132901990.0MotifNote=LXXLL motif 1
HgeneMED24chr17:38176526chr17:37949186ENST00000394128-2426344_348901990.0MotifNote=LXXLL motif 2
HgeneMED24chr17:38176526chr17:37949186ENST00000394128-2426448_452901990.0MotifNote=LXXLL motif 3
HgeneMED24chr17:38176526chr17:37949186ENST00000394128-2426557_561901990.0MotifNote=LXXLL motif 4
HgeneMED24chr17:38176526chr17:37949186ENST00000394128-2426788_792901990.0MotifNote=LXXLL motif 5
HgeneMED24chr17:38176526chr17:37949186ENST00000394128-2426857_861901990.0MotifNote=LXXLL motif 6
TgeneIKZF3chr17:38176526chr17:37949186ENST0000034624326118_14054432.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38176526chr17:37949186ENST0000034624326146_16854432.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38176526chr17:37949186ENST0000034624326174_19654432.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38176526chr17:37949186ENST0000034624326202_22454432.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38176526chr17:37949186ENST0000034624326452_47454432.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38176526chr17:37949186ENST0000034624326480_50454432.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38176526chr17:37949186ENST0000034687228118_14054510.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38176526chr17:37949186ENST0000034687228146_16854510.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38176526chr17:37949186ENST0000034687228174_19654510.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38176526chr17:37949186ENST0000034687228202_22454510.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38176526chr17:37949186ENST0000034687228452_47454510.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38176526chr17:37949186ENST0000034687228480_50454510.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38176526chr17:37949186ENST0000035053227118_14054471.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38176526chr17:37949186ENST0000035053227146_16854471.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38176526chr17:37949186ENST0000035053227174_19654471.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38176526chr17:37949186ENST0000035053227202_22454471.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38176526chr17:37949186ENST0000035053227452_47454471.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38176526chr17:37949186ENST0000035053227480_50454471.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38176526chr17:37949186ENST0000035168027118_14054471.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38176526chr17:37949186ENST0000035168027146_16854471.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38176526chr17:37949186ENST0000035168027174_19654471.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38176526chr17:37949186ENST0000035168027202_22454471.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38176526chr17:37949186ENST0000035168027452_47454471.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38176526chr17:37949186ENST0000035168027480_50454471.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38176526chr17:37949186ENST0000037794406118_1400367.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38176526chr17:37949186ENST0000037794406146_1680367.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38176526chr17:37949186ENST0000037794406174_1960367.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38176526chr17:37949186ENST0000037794406202_2240367.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38176526chr17:37949186ENST0000037794406452_4740367.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38176526chr17:37949186ENST0000037794406480_5040367.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38176526chr17:37949186ENST0000037794525118_14054376.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38176526chr17:37949186ENST0000037794525146_16854376.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38176526chr17:37949186ENST0000037794525174_19654376.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38176526chr17:37949186ENST0000037794525202_22454376.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38176526chr17:37949186ENST0000037794525452_47454376.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38176526chr17:37949186ENST0000037794525480_50454376.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38176526chr17:37949186ENST0000037795204118_1400289.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38176526chr17:37949186ENST0000037795204146_1680289.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38176526chr17:37949186ENST0000037795204174_1960289.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38176526chr17:37949186ENST0000037795204202_2240289.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38176526chr17:37949186ENST0000037795204452_4740289.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38176526chr17:37949186ENST0000037795204480_5040289.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38176526chr17:37949186ENST0000037795807118_1400423.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38176526chr17:37949186ENST0000037795807146_1680423.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38176526chr17:37949186ENST0000037795807174_1960423.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38176526chr17:37949186ENST0000037795807202_2240423.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38176526chr17:37949186ENST0000037795807452_4740423.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38176526chr17:37949186ENST0000037795807480_5040423.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38176526chr17:37949186ENST0000039418905118_1400328.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38176526chr17:37949186ENST0000039418905146_1680328.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38176526chr17:37949186ENST0000039418905174_1960328.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38176526chr17:37949186ENST0000039418905202_2240328.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38176526chr17:37949186ENST0000039418905452_4740328.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38176526chr17:37949186ENST0000039418905480_5040328.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38176526chr17:37949186ENST0000043901626118_14054415.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38176526chr17:37949186ENST0000043901626146_16854415.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38176526chr17:37949186ENST0000043901626174_19654415.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38176526chr17:37949186ENST0000043901626202_22454415.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38176526chr17:37949186ENST0000043901626452_47454415.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38176526chr17:37949186ENST0000043901626480_50454415.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38176526chr17:37949186ENST0000043916716118_14020437.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38176526chr17:37949186ENST0000043916716146_16820437.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38176526chr17:37949186ENST0000043916716174_19620437.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38176526chr17:37949186ENST0000043916716202_22420437.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38176526chr17:37949186ENST0000043916716452_47420437.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38176526chr17:37949186ENST0000043916716480_50420437.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38176526chr17:37949186ENST0000046775727118_14054454.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38176526chr17:37949186ENST0000046775727146_16854454.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38176526chr17:37949186ENST0000046775727174_19654454.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38176526chr17:37949186ENST0000046775727202_22454454.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38176526chr17:37949186ENST0000046775727452_47454454.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38176526chr17:37949186ENST0000046775727480_50454454.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38176526chr17:37949186ENST0000053518917118_14020476.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38176526chr17:37949186ENST0000053518917146_16820476.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38176526chr17:37949186ENST0000053518917174_19620476.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38176526chr17:37949186ENST0000053518917202_22420476.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38176526chr17:37949186ENST0000053518917452_47420476.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38176526chr17:37949186ENST0000053518917480_50420476.0Zinc fingerC2H2-type 6%3B atypical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MED24-IKZF3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>52712_52712_1_MED24-IKZF3_MED24_chr17_38176526_ENST00000394126_IKZF3_chr17_37949186_ENST00000346872_length(transcript)=5410nt_BP=3198nt
GGTGCGATCTCGGCTCACCCCAACAACCTCCGCCTCCCGGGTTCAAGCGATTCTACTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGC
ATGCACCACCAAGCCCGGCTAATTTTGTATTTTTAGTGGAGACGAGGTTTCTCCATGTTGGTCAGGCTAGTCTCGAACTCCTGACCTCCG
GTGATTCGCCCGCCTCTGCCTCCCGAAGTGCTGGGATTACAGGTGCGAGCCACTGCGCTCGGCCGATACTTTCTTAGTGCCCCAGTTTAA
GGAAGGGCGGTTCAGGAGGAGAGAGTCTGACAGGATCTTACTTTATCCCTTTAGCTCTTTTTCTTTCAAATTCCTCTGTCTCGCTTAAAT
CTTCCCGCATCTTCTCCTTTCTATTTAATTCTGCCTTCCCCGGTTCTCCTTAGAACCTCATGTCCTTTTCTTTAGCTCCATTTCTTTCAC
CTCAAAGCTGGCCGCCACCGCTGCCACCTGCTCAGAGTGAAATAATGAAGGTGGTCAACCTGAAGCAAGCCATTTTGCAAGCCTGGAAGG
AGCGCTGGAGTGACTACCAATGGGCAATCAACATGAAGAAATTCTTTCCTAAAGGAGCCACCTGGGATATTCTCAACCTGGCAGATGCGT
TACTAGAGCAGGCCATGATTGGACCATCCCCCAATCCTCTCATCTTGTCCTACCTGAAGTATGCCATTAGTTCCCAGATGGTGTCCTACT
CTTCTGTCCTCACAGCCATCAGTAAGTTTGATGACTTTTCTCGGGACCTGTGTGTCCAGGCATTGCTGGACATCATGGACATGTTTTGTG
ACCGTCTGAGCTGTCACGGCAAAGCAGAGGAATGCATCGGACTGTGCCGAGCCCTTCTTAGCGCCCTCCACTGGCTGCTGCGCTGCACGG
CAGCCTCTGCAGAGCGGCTGCGGGAGGGGCTGGAGGCCGGCACTCCAGCCGCTGGGGAGAAGCAGCTTGCCATGTGCCTTCAGCGCCTGG
AGAAAACCCTCAGCAGCACCAAGAACCGGGCCCTGCTGCACATCGCCAAACTAGAGGAGGCCTCTTCTTGGACTGCCATCGAGCATTCTC
TCTTGAAACTTGGAGAGATCCTGGCCAATCTCAGCAACCCGCAGCTCCGGAGTCAGGCCGAGCAGTGTGGCACCCTCATTAGGAGCATCC
CCACGATGCTGTCTGTGCATGCGGAGCAGATGCACAAGACCGGCTTCCCCACTGTCCACGCCGTGATCCTGCTCGAGGGCACCATGAACC
TGACAGGCGAGACGCAGTCCCTGGTGGAGCAGCTGACGATGGTGAAGCGCATGCAGCATATCCCCACCCCACTTTTTGTCCTGGAGATCT
GGAAAGCTTGCTTCGTGGGGCTCATTGAGTCTCCCGAGGGTACGGAGGAGCTCAAGTGGACAGCTTTCACTTTCCTCAAGATTCCACAGG
TTTTGGTGAAGTTGAAGAAGTACTCTCATGGAGACAAGGACTTCACTGAGGATGTCAACTGTGCTTTTGAGTTCCTGCTGAAGCTCACCC
CCTTGTTGGACAAAGCTGACCAGCGCTGCAACTGTGACTGTACAAACTTCCTGCTCCAAGAATGTGGCAAGCAGGGGCTTCTGTCTGAGG
CCAGCGTCAACAACCTTATGGCTAAGCGCAAAGCGGACCGAGAGCACGCACCCCAGCAGAAATCGGGAGAGAATGCCAACATCCAGCCCA
ACATCCAGCTGATCCTCCGGGCGGAGCCCACTGTCACAAACATCCTCAAGACGATGGATGCAGACCACTCTAAGTCACCGGAGGGACTGC
TGGGAGTCCTGGGCCACATGCTGTCCGGGAAGAGTCTGGACTTGCTGCTGGCTGCCGCCGCCGCCACTGGAAAGCTGAAATCCTTCGCCC
GGAAATTCATCAATTTGAATGAATTCACAACCTATGGCAGCGAAGAAAGCACCAAACCGGCCTCCGTCCGGGCCCTGCTGTTTGACATCT
CCTTCCTCATGCTGTGCCATGTGGCCCAGACCTATGGTTCAGAGGTGATTCTGTCCGAGTCGCGCACAGGAGCTGAGGTGCCCTTCTTCG
AGACCTGGATGCAGACCTGCATGCCTGAGGAGGGCAAGATCCTGAACCCTGACCACCCCTGCTTCCGCCCCGACTCCACCAAAGTGGAGT
CCCTGGTGGCCCTGCTCAACAACTCCTCGGAGATGAAGCTAGTGCAGATGAAGTGGCATGAGGCCTGTCTCAGCATCTCAGCCGCCATCT
TGGAAATCCTCAATGCCTGGGAGAATGGGGTCCTGGCCTTCGAGTCCATCCAGAAAATCACTGATAACATCAAAGGGAAGGTATGCAGTC
TGGCGGTGTGTGCTGTGGCTTGGCTTGTGGCCCACGTCCGGATGCTGGGGCTGGATGAGCGTGAGAAGTCGCTGCAGATGATCCGCCAGC
TGGCAGGGCCACTGTTTAGTGAGAACACCCTGCAGTTCTACAATGAGAGGGTGGTGATCATGAACTCGATCCTGGAGCGCATGTGTGCCG
ACGTGCTGCAGCAGACAGCCACGCAGATCAAGTTTCCCTCCACCGGGGTGGACACAATGCCCTACTGGAACCTGCTGCCCCCCAAGCGGC
CCATCAAAGAGGTGCTGACGGACATTTTTGCCAAGGTGCTGGAGAAGGGCTGGGTGGACAGCCGCTCCATCCACATCTTTGACACCCTGC
TGCACATGGGCGGCGTCTACTGGTTCTGCAACAACCTGATTAAGGAGCTGCTGAAGGAGACGCGGAAGGAGCACACGCTGCGGGCAGTGG
AGCTGCTCTACTCCATCTTCTGCCTGGACATGCAGCAAGTGACCCTGGTCCTGCTGGGCCACATCCTACCTGGCCTGCTCACTGACTCCT
CCAAGTGGCACAGCCTCATGGACCCCCCGGGCACTGCTCTTGCCAAGCTGGCCGTGTGGTGTGCCCTCAGTTCCTACTCCTCCCACAAGG
GACAGGCGTCCACCCGCCAGAAGAAGAGACACCGCGAAGACATTGAGGATTATATCAGCCTCTTCCCCCTGGACGATGTGCAGCCTTCGA
AGTTGATGCGACTGCTGAGCTCTAATGAGGACGATGCCAACATCCTTTCGAGCCCCACAGACCGATCCATGAGCAGCTCCCTCTCAGCCT
CTCAGCTCCACACGGTCAACATGCGGGACCCTCTGAACCGAGTCCTGGATGATTCAATGAAAGTGAAAGATGAATACAGTGAAAGAGATG
AGAATGTTTTAAAGTCAGAACCCATGGGAAATGCAGAAGAGCCTGAAATCCCTTACAGCTATTCAAGAGAATATAATGAATATGAAAACA
TTAAGTTGGAGAGACATGTTGTCTCATTCGATAGTAGCAGGCCAACCAGTGGAAAGATGAACTGCGATGTGTGTGGATTATCCTGCATCA
GCTTCAATGTCTTAATGGTTCATAAGCGAAGCCATACTGGTGAACGCCCATTCCAGTGTAATCAGTGTGGGGCATCTTTTACTCAGAAAG
GTAACCTCCTCCGCCACATTAAACTGCACACAGGGGAAAAACCTTTTAAGTGTCACCTCTGCAACTATGCATGCCAAAGAAGAGATGCGC
TCACGGGGCATCTTAGGACACATTCTGTGGAGAAACCCTACAAATGTGAGTTTTGTGGAAGGAGTTACAAGCAGAGAAGTTCCCTTGAGG
AGCACAAGGAGCGCTGCCGTACATTTCTTCAGAGCACTGACCCAGGGGACACTGCAAGTGCGGAGGCAAGACACATCAAAGCAGAGATGG
GAAGTGAAAGAGCTCTCGTACTGGACAGATTAGCAAGCAATGTGGCAAAACGAAAAAGCTCAATGCCTCAGAAATTCATTGGTGAGAAGC
GCCACTGCTTTGATGTCAACTATAATTCAAGTTACATGTATGAGAAAGAGAGTGAGCTCATACAGACCCGCATGATGGACCAAGCCATCA
ATAACGCCATCAGCTATCTTGGCGCCGAAGCCCTGCGCCCCTTGGTCCAGACACCGCCTGCTCCCACCTCGGAGATGGTTCCAGTTATCA
GCAGCATGTATCCCATAGCCCTCACCCGGGCTGAGATGTCAAACGGTGCCCCTCAAGAGCTGGAAAAGAAAAGCATCCACCTTCCAGAGA
AGAGCGTGCCTTCTGAGAGAGGCCTCTCTCCCAACAATAGTGGCCACGACTCCACGGACACTGACAGCAACCATGAAGAACGCCAGAATC
ACATCTATCAGCAAAATCACATGGTCCTGTCTCGGGCCCGCAATGGGATGCCACTTCTGAAGGAGGTTCCCCGCTCTTACGAACTCCTCA
AGCCCCCGCCCATCTGCCCAAGAGACTCCGTCAAAGTGATCAACAAGGAAGGGGAGGTGATGGATGTGTATCGGTGTGACCACTGCCGCG
TCCTCTTCCTGGACTATGTGATGTTCACGATTCACATGGGCTGCCACGGCTTCCGTGACCCTTTCGAGTGTAACATGTGTGGATATCGAA
GCCATGATCGGTATGAGTTCTCGTCTCACATAGCCAGAGGAGAACACAGAGCCCTGCTGAAGTGAATATCTGGTCTCAGGGATTGCTCCT
ATGTATTCAGCATCGTTTCTAAAAACCAATGACCTCGCCTAACAGATTGCTCTCAAAACATACTCAGTTCCAAACTTCTTTTCATACCAT
TTTTAGCTGTGTTCACAGGGGTAGCCAGGGAAACACTGTCTTCCTTCAGAAATTATTCGCAGGTCTAGCATATTATTACTTTTGTGAAAC
CTTTGTTTTCCCATCAGGGACTTGAATTTTATGGAATTTAAAAGCCAAAAAGGTATTTGGTCATTATCTTCTACAGCAGTGGAATGAGTG
GTCCCGGAGATGTGCTATATGAAACATTCTTTCTGAGATATATCAACCACACGTGGAAAAGCCTTTCAGTCATACATGCAAATCCACAAA
GAGGAAGAGCTGACCAGCTGACCTTGCTGGGAAGCCTCACCCTTCTGCCCTTCACAGGCTGAAGGGTTAAGATCTAATCTCCCTAATCTA
AATGACAGTCTAAGAGTAAGTAAAAGAACAGCCATAAAATAAGTATCTGTTACGAGTAACTGAAGACCCCATTCTCCAAGCATCAGATCC
ATTTCCTATCACAACATTTTTAAAAAATGTCATCTGATGGCACTTCTGCTTCTGTCCTTTACCTTCCCATCTCCAGTGAAAAGCTGAGCT
GCTTTGGGCTAAACCAGTTGTCTATAGAAGAAAATCTATGCCAGAAGAACTCATGGTTTTAAATATAGACCATCATCGAAACTCCAGAAA
TTTATCCACTGTGGATGATGACATCGCTTTCCTTTGGTCAAGGTTGGCAGAGCAAGGGTATAAAGGGGGAAATTGTTTGGCAGCACCAAC

>52712_52712_1_MED24-IKZF3_MED24_chr17_38176526_ENST00000394126_IKZF3_chr17_37949186_ENST00000346872_length(amino acids)=1381AA_BP=0
MSFSLAPFLSPQSWPPPLPPAQSEIMKVVNLKQAILQAWKERWSDYQWAINMKKFFPKGATWDILNLADALLEQAMIGPSPNPLILSYLK
YAISSQMVSYSSVLTAISKFDDFSRDLCVQALLDIMDMFCDRLSCHGKAEECIGLCRALLSALHWLLRCTAASAERLREGLEAGTPAAGE
KQLAMCLQRLEKTLSSTKNRALLHIAKLEEASSWTAIEHSLLKLGEILANLSNPQLRSQAEQCGTLIRSIPTMLSVHAEQMHKTGFPTVH
AVILLEGTMNLTGETQSLVEQLTMVKRMQHIPTPLFVLEIWKACFVGLIESPEGTEELKWTAFTFLKIPQVLVKLKKYSHGDKDFTEDVN
CAFEFLLKLTPLLDKADQRCNCDCTNFLLQECGKQGLLSEASVNNLMAKRKADREHAPQQKSGENANIQPNIQLILRAEPTVTNILKTMD
ADHSKSPEGLLGVLGHMLSGKSLDLLLAAAAATGKLKSFARKFINLNEFTTYGSEESTKPASVRALLFDISFLMLCHVAQTYGSEVILSE
SRTGAEVPFFETWMQTCMPEEGKILNPDHPCFRPDSTKVESLVALLNNSSEMKLVQMKWHEACLSISAAILEILNAWENGVLAFESIQKI
TDNIKGKVCSLAVCAVAWLVAHVRMLGLDEREKSLQMIRQLAGPLFSENTLQFYNERVVIMNSILERMCADVLQQTATQIKFPSTGVDTM
PYWNLLPPKRPIKEVLTDIFAKVLEKGWVDSRSIHIFDTLLHMGGVYWFCNNLIKELLKETRKEHTLRAVELLYSIFCLDMQQVTLVLLG
HILPGLLTDSSKWHSLMDPPGTALAKLAVWCALSSYSSHKGQASTRQKKRHREDIEDYISLFPLDDVQPSKLMRLLSSNEDDANILSSPT
DRSMSSSLSASQLHTVNMRDPLNRVLDDSMKVKDEYSERDENVLKSEPMGNAEEPEIPYSYSREYNEYENIKLERHVVSFDSSRPTSGKM
NCDVCGLSCISFNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHTGEKPFKCHLCNYACQRRDALTGHLRTHSVEKPYKCEFCG
RSYKQRSSLEEHKERCRTFLQSTDPGDTASAEARHIKAEMGSERALVLDRLASNVAKRKSSMPQKFIGEKRHCFDVNYNSSYMYEKESEL
IQTRMMDQAINNAISYLGAEALRPLVQTPPAPTSEMVPVISSMYPIALTRAEMSNGAPQELEKKSIHLPEKSVPSERGLSPNNSGHDSTD
TDSNHEERQNHIYQQNHMVLSRARNGMPLLKEVPRSYELLKPPPICPRDSVKVINKEGEVMDVYRCDHCRVLFLDYVMFTIHMGCHGFRD

--------------------------------------------------------------
>52712_52712_2_MED24-IKZF3_MED24_chr17_38176526_ENST00000501516_IKZF3_chr17_37949186_ENST00000346872_length(transcript)=4983nt_BP=2771nt
GAGTGAAATAATGAAGGTGGTCAACCTGAAGCAAGCCATTTTGCAAGCCTGGAAGGAGCGCTGGAGTGACTACCAATGGGCAATCAACAT
GAAGAAATTCTTTCCTAAAGGAGCCACCTGGGATATTCTCAACCTGGCAGATGCGTTACTAGAGCAGGCCATGATTGGACCATCCCCCAA
TCCTCTCATCTTGTCCTACCTGAAGTATGCCATTAGTTCCCAGATGGTGTCCTACTCTTCTGTCCTCACAGCCATCAGTAAGTTTGATGA
CTTTTCTCGGGACCTGTGTGTCCAGGCATTGCTGGACATCATGGACATGTTTTGTGACCGTCTGAGCTGTCACGGCAAAGCAGAGGAATG
CATCGGACTGTGCCGAGCCCTTCTTAGCGCCCTCCACTGGCTGCTGCGCTGCACGGCAGCCTCTGCAGAGCGGCTGCGGGAGGGGCTGGA
GGCCGGCACTCCAGCCGCTGGGGAGAAGCAGCTTGCCATGTGCCTTCAGCGCCTGGAGAAAACCCTCAGCAGCACCAAGAACCGGGCCCT
GCTGCACATCGCCAAACTAGAGGAGGCCTCATTGCACACATCCCAGGGACTTGGGCAGGGTGGCACCCGAGCCAATCAACCAACAGCTTC
TTGGACTGCCATCGAGCATTCTCTCTTGAAACTTGGAGAGATCCTGGCCAATCTCAGCAACCCGCAGCTCCGGAGTCAGGCCGAGCAGTG
TGGCACCCTCATTAGGAGCATCCCCACGATGCTGTCTGTGCATGCGGAGCAGATGCACAAGACCGGCTTCCCCACTGTCCACGCCGTGAT
CCTGCTCGAGGGCACCATGAACCTGACAGGCGAGACGCAGTCCCTGGTGGAGCAGCTGACGATGGTGAAGCGCATGCAGCATATCCCCAC
CCCACTTTTTGTCCTGGAGATCTGGAAAGCTTGCTTCGTGGGGCTCATTGAGTCTCCCGAGGGTACGGAGGAGCTCAAGTGGACAGCTTT
CACTTTCCTCAAGATTCCACAGGTTTTGGTGAAGTTGAAGAAGTACTCTCATGGAGACAAGGACTTCACTGAGGATGTCAACTGTGCTTT
TGAGTTCCTGCTGAAGCTCACCCCCTTGTTGGACAAAGCTGACCAGCGCTGCAACTGTGACTGTACAAACTTCCTGCTCCAAGAATGTGG
CAAGCAGGGGCTTCTGTCTGAGGCCAGCGTCAACAACCTTATGGCTAAGCGCAAAGCGGACCGAGAGCACGCACCCCAGCAGAAATCGGG
AGAGAATGCCAACATCCAGCCCAACATCCAGCTGATCCTCCGGGCGGAGCCCACTGTCACAAACATCCTCAAGACGATGGATGCAGACCA
CTCTAAGTCACCGGAGGGACTGCTGGGAGTCCTGGGCCACATGCTGTCCGGGAAGAGTCTGGACTTGCTGCTGGCTGCCGCCGCCGCCAC
TGGAAAGCTGAAATCCTTCGCCCGGAAATTCATCAATTTGAATGAATTCACAACCTATGGCAGCGAAGAAAGCACCAAACCGGCCTCCGT
CCGGGCCCTGCTGTTTGACATCTCCTTCCTCATGCTGTGCCATGTGGCCCAGACCTATGGTTCAGAGGTGATTCTGTCCGAGTCGCGCAC
AGGAGCTGAGGTGCCCTTCTTCGAGACCTGGATGCAGACCTGCATGCCTGAGGAGGGCAAGATCCTGAACCCTGACCACCCCTGCTTCCG
CCCCGACTCCACCAAAGTGGAGTCCCTGGTGGCCCTGCTCAACAACTCCTCGGAGATGAAGCTAGTGCAGATGAAGTGGCATGAGGCCTG
TCTCAGCATCTCAGCCGCCATCTTGGAAATCCTCAATGCCTGGGAGAATGGGGTCCTGGCCTTCGAGTCCATCCAGAAAATCACTGATAA
CATCAAAGGGAAGGTATGCAGTCTGGCGGTGTGTGCTGTGGCTTGGCTTGTGGCCCACGTCCGGATGCTGGGGCTGGATGAGCGTGAGAA
GTCGCTGCAGATGATCCGCCAGCTGGCAGGGCCACTGTTTAGTGAGAACACCCTGCAGTTCTACAATGAGAGGGTGGTGATCATGAACTC
GATCCTGGAGCGCATGTGTGCCGACGTGCTGCAGCAGACAGCCACGCAGATCAAGTTTCCCTCCACCGGGGTGGACACAATGCCCTACTG
GAACCTGCTGCCCCCCAAGCGGCCCATCAAAGAGGTGCTGACGGACATTTTTGCCAAGGTGCTGGAGAAGGGCTGGGTGGACAGCCGCTC
CATCCACATCTTTGACACCCTGCTGCACATGGGCGGCGTCTACTGGTTCTGCAACAACCTGATTAAGGAGCTGCTGAAGGAGACGCGGAA
GGAGCACACGCTGCGGGCAGTGGAGCTGCTCTACTCCATCTTCTGCCTGGACATGCAGCAAGTGACCCTGGTCCTGCTGGGCCACATCCT
ACCTGGCCTGCTCACTGACTCCTCCAAGTGGCACAGCCTCATGGACCCCCCGGGCACTGCTCTTGCCAAGCTGGCCGTGTGGTGTGCCCT
CAGTTCCTACTCCTCCCACAAGGGACAGGCGTCCACCCGCCAGAAGAAGAGACACCGCGAAGACATTGAGGATTATATCAGCCTCTTCCC
CCTGGACGATGTGCAGCCTTCGAAGTTGATGCGACTGCTGAGCTCTAATGAGGACGATGCCAACATCCTTTCGAGCCCCACAGACCGATC
CATGAGCAGCTCCCTCTCAGCCTCTCAGCTCCACACGGTCAACATGCGGGACCCTCTGAACCGAGTCCTGGATGATTCAATGAAAGTGAA
AGATGAATACAGTGAAAGAGATGAGAATGTTTTAAAGTCAGAACCCATGGGAAATGCAGAAGAGCCTGAAATCCCTTACAGCTATTCAAG
AGAATATAATGAATATGAAAACATTAAGTTGGAGAGACATGTTGTCTCATTCGATAGTAGCAGGCCAACCAGTGGAAAGATGAACTGCGA
TGTGTGTGGATTATCCTGCATCAGCTTCAATGTCTTAATGGTTCATAAGCGAAGCCATACTGGTGAACGCCCATTCCAGTGTAATCAGTG
TGGGGCATCTTTTACTCAGAAAGGTAACCTCCTCCGCCACATTAAACTGCACACAGGGGAAAAACCTTTTAAGTGTCACCTCTGCAACTA
TGCATGCCAAAGAAGAGATGCGCTCACGGGGCATCTTAGGACACATTCTGTGGAGAAACCCTACAAATGTGAGTTTTGTGGAAGGAGTTA
CAAGCAGAGAAGTTCCCTTGAGGAGCACAAGGAGCGCTGCCGTACATTTCTTCAGAGCACTGACCCAGGGGACACTGCAAGTGCGGAGGC
AAGACACATCAAAGCAGAGATGGGAAGTGAAAGAGCTCTCGTACTGGACAGATTAGCAAGCAATGTGGCAAAACGAAAAAGCTCAATGCC
TCAGAAATTCATTGGTGAGAAGCGCCACTGCTTTGATGTCAACTATAATTCAAGTTACATGTATGAGAAAGAGAGTGAGCTCATACAGAC
CCGCATGATGGACCAAGCCATCAATAACGCCATCAGCTATCTTGGCGCCGAAGCCCTGCGCCCCTTGGTCCAGACACCGCCTGCTCCCAC
CTCGGAGATGGTTCCAGTTATCAGCAGCATGTATCCCATAGCCCTCACCCGGGCTGAGATGTCAAACGGTGCCCCTCAAGAGCTGGAAAA
GAAAAGCATCCACCTTCCAGAGAAGAGCGTGCCTTCTGAGAGAGGCCTCTCTCCCAACAATAGTGGCCACGACTCCACGGACACTGACAG
CAACCATGAAGAACGCCAGAATCACATCTATCAGCAAAATCACATGGTCCTGTCTCGGGCCCGCAATGGGATGCCACTTCTGAAGGAGGT
TCCCCGCTCTTACGAACTCCTCAAGCCCCCGCCCATCTGCCCAAGAGACTCCGTCAAAGTGATCAACAAGGAAGGGGAGGTGATGGATGT
GTATCGGTGTGACCACTGCCGCGTCCTCTTCCTGGACTATGTGATGTTCACGATTCACATGGGCTGCCACGGCTTCCGTGACCCTTTCGA
GTGTAACATGTGTGGATATCGAAGCCATGATCGGTATGAGTTCTCGTCTCACATAGCCAGAGGAGAACACAGAGCCCTGCTGAAGTGAAT
ATCTGGTCTCAGGGATTGCTCCTATGTATTCAGCATCGTTTCTAAAAACCAATGACCTCGCCTAACAGATTGCTCTCAAAACATACTCAG
TTCCAAACTTCTTTTCATACCATTTTTAGCTGTGTTCACAGGGGTAGCCAGGGAAACACTGTCTTCCTTCAGAAATTATTCGCAGGTCTA
GCATATTATTACTTTTGTGAAACCTTTGTTTTCCCATCAGGGACTTGAATTTTATGGAATTTAAAAGCCAAAAAGGTATTTGGTCATTAT
CTTCTACAGCAGTGGAATGAGTGGTCCCGGAGATGTGCTATATGAAACATTCTTTCTGAGATATATCAACCACACGTGGAAAAGCCTTTC
AGTCATACATGCAAATCCACAAAGAGGAAGAGCTGACCAGCTGACCTTGCTGGGAAGCCTCACCCTTCTGCCCTTCACAGGCTGAAGGGT
TAAGATCTAATCTCCCTAATCTAAATGACAGTCTAAGAGTAAGTAAAAGAACAGCCATAAAATAAGTATCTGTTACGAGTAACTGAAGAC
CCCATTCTCCAAGCATCAGATCCATTTCCTATCACAACATTTTTAAAAAATGTCATCTGATGGCACTTCTGCTTCTGTCCTTTACCTTCC
CATCTCCAGTGAAAAGCTGAGCTGCTTTGGGCTAAACCAGTTGTCTATAGAAGAAAATCTATGCCAGAAGAACTCATGGTTTTAAATATA
GACCATCATCGAAACTCCAGAAATTTATCCACTGTGGATGATGACATCGCTTTCCTTTGGTCAAGGTTGGCAGAGCAAGGGTATAAAGGG

>52712_52712_2_MED24-IKZF3_MED24_chr17_38176526_ENST00000501516_IKZF3_chr17_37949186_ENST00000346872_length(amino acids)=1375AA_BP=0
MKVVNLKQAILQAWKERWSDYQWAINMKKFFPKGATWDILNLADALLEQAMIGPSPNPLILSYLKYAISSQMVSYSSVLTAISKFDDFSR
DLCVQALLDIMDMFCDRLSCHGKAEECIGLCRALLSALHWLLRCTAASAERLREGLEAGTPAAGEKQLAMCLQRLEKTLSSTKNRALLHI
AKLEEASLHTSQGLGQGGTRANQPTASWTAIEHSLLKLGEILANLSNPQLRSQAEQCGTLIRSIPTMLSVHAEQMHKTGFPTVHAVILLE
GTMNLTGETQSLVEQLTMVKRMQHIPTPLFVLEIWKACFVGLIESPEGTEELKWTAFTFLKIPQVLVKLKKYSHGDKDFTEDVNCAFEFL
LKLTPLLDKADQRCNCDCTNFLLQECGKQGLLSEASVNNLMAKRKADREHAPQQKSGENANIQPNIQLILRAEPTVTNILKTMDADHSKS
PEGLLGVLGHMLSGKSLDLLLAAAAATGKLKSFARKFINLNEFTTYGSEESTKPASVRALLFDISFLMLCHVAQTYGSEVILSESRTGAE
VPFFETWMQTCMPEEGKILNPDHPCFRPDSTKVESLVALLNNSSEMKLVQMKWHEACLSISAAILEILNAWENGVLAFESIQKITDNIKG
KVCSLAVCAVAWLVAHVRMLGLDEREKSLQMIRQLAGPLFSENTLQFYNERVVIMNSILERMCADVLQQTATQIKFPSTGVDTMPYWNLL
PPKRPIKEVLTDIFAKVLEKGWVDSRSIHIFDTLLHMGGVYWFCNNLIKELLKETRKEHTLRAVELLYSIFCLDMQQVTLVLLGHILPGL
LTDSSKWHSLMDPPGTALAKLAVWCALSSYSSHKGQASTRQKKRHREDIEDYISLFPLDDVQPSKLMRLLSSNEDDANILSSPTDRSMSS
SLSASQLHTVNMRDPLNRVLDDSMKVKDEYSERDENVLKSEPMGNAEEPEIPYSYSREYNEYENIKLERHVVSFDSSRPTSGKMNCDVCG
LSCISFNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHTGEKPFKCHLCNYACQRRDALTGHLRTHSVEKPYKCEFCGRSYKQR
SSLEEHKERCRTFLQSTDPGDTASAEARHIKAEMGSERALVLDRLASNVAKRKSSMPQKFIGEKRHCFDVNYNSSYMYEKESELIQTRMM
DQAINNAISYLGAEALRPLVQTPPAPTSEMVPVISSMYPIALTRAEMSNGAPQELEKKSIHLPEKSVPSERGLSPNNSGHDSTDTDSNHE
ERQNHIYQQNHMVLSRARNGMPLLKEVPRSYELLKPPPICPRDSVKVINKEGEVMDVYRCDHCRVLFLDYVMFTIHMGCHGFRDPFECNM

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Fusion Gene PPI Analysis for MED24-IKZF3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MED24-IKZF3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MED24-IKZF3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource