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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MED24-SSH2 (FusionGDB2 ID:52721)

Fusion Gene Summary for MED24-SSH2

check button Fusion gene summary
Fusion gene informationFusion gene name: MED24-SSH2
Fusion gene ID: 52721
HgeneTgene
Gene symbol

MED24

SSH2

Gene ID

9862

85464

Gene namemediator complex subunit 24slingshot protein phosphatase 2
SynonymsARC100|CRSP100|CRSP4|DRIP100|MED5|THRAP4|TRAP100SSH-2|SSH-2L
Cytomap

17q21.1

17q11.2

Type of geneprotein-codingprotein-coding
Descriptionmediator of RNA polymerase II transcription subunit 24CRSP complex subunit 4activator-recruited cofactor 100 kDa componentcofactor required for Sp1 transcriptional activation subunit 4cofactor required for Sp1 transcriptional activation, subunit 4, 10protein phosphatase Slingshot homolog 2SSH-like protein 2
Modification date2020031320200313
UniProtAcc

O75448

.
Ensembl transtripts involved in fusion geneENST00000356271, ENST00000394126, 
ENST00000394127, ENST00000394128, 
ENST00000501516, ENST00000479829, 
ENST00000324677, ENST00000579954, 
ENST00000582084, ENST00000590153, 
ENST00000269033, ENST00000540801, 
Fusion gene scores* DoF score21 X 18 X 9=340225 X 21 X 10=5250
# samples 2631
** MAII scorelog2(26/3402*10)=-3.70979961263493
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(31/5250*10)=-4.08197730216661
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MED24 [Title/Abstract] AND SSH2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMED24(38209551)-SSH2(28030080), # samples:3
Anticipated loss of major functional domain due to fusion event.MED24-SSH2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
MED24-SSH2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
MED24-SSH2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMED24

GO:0006367

transcription initiation from RNA polymerase II promoter

12218053

HgeneMED24

GO:0045893

positive regulation of transcription, DNA-templated

10198638


check buttonFusion gene breakpoints across MED24 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SSH2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-B6-A0WV-01AMED24chr17

38209551

-SSH2chr17

28030080

-


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Fusion Gene ORF analysis for MED24-SSH2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000356271ENST00000324677MED24chr17

38209551

-SSH2chr17

28030080

-
5CDS-5UTRENST00000394126ENST00000324677MED24chr17

38209551

-SSH2chr17

28030080

-
5CDS-5UTRENST00000394127ENST00000324677MED24chr17

38209551

-SSH2chr17

28030080

-
5CDS-5UTRENST00000394128ENST00000324677MED24chr17

38209551

-SSH2chr17

28030080

-
5CDS-5UTRENST00000501516ENST00000324677MED24chr17

38209551

-SSH2chr17

28030080

-
5CDS-intronENST00000356271ENST00000579954MED24chr17

38209551

-SSH2chr17

28030080

-
5CDS-intronENST00000356271ENST00000582084MED24chr17

38209551

-SSH2chr17

28030080

-
5CDS-intronENST00000356271ENST00000590153MED24chr17

38209551

-SSH2chr17

28030080

-
5CDS-intronENST00000394126ENST00000579954MED24chr17

38209551

-SSH2chr17

28030080

-
5CDS-intronENST00000394126ENST00000582084MED24chr17

38209551

-SSH2chr17

28030080

-
5CDS-intronENST00000394126ENST00000590153MED24chr17

38209551

-SSH2chr17

28030080

-
5CDS-intronENST00000394127ENST00000579954MED24chr17

38209551

-SSH2chr17

28030080

-
5CDS-intronENST00000394127ENST00000582084MED24chr17

38209551

-SSH2chr17

28030080

-
5CDS-intronENST00000394127ENST00000590153MED24chr17

38209551

-SSH2chr17

28030080

-
5CDS-intronENST00000394128ENST00000579954MED24chr17

38209551

-SSH2chr17

28030080

-
5CDS-intronENST00000394128ENST00000582084MED24chr17

38209551

-SSH2chr17

28030080

-
5CDS-intronENST00000394128ENST00000590153MED24chr17

38209551

-SSH2chr17

28030080

-
5CDS-intronENST00000501516ENST00000579954MED24chr17

38209551

-SSH2chr17

28030080

-
5CDS-intronENST00000501516ENST00000582084MED24chr17

38209551

-SSH2chr17

28030080

-
5CDS-intronENST00000501516ENST00000590153MED24chr17

38209551

-SSH2chr17

28030080

-
5UTR-3CDSENST00000479829ENST00000269033MED24chr17

38209551

-SSH2chr17

28030080

-
5UTR-3CDSENST00000479829ENST00000540801MED24chr17

38209551

-SSH2chr17

28030080

-
5UTR-5UTRENST00000479829ENST00000324677MED24chr17

38209551

-SSH2chr17

28030080

-
5UTR-intronENST00000479829ENST00000579954MED24chr17

38209551

-SSH2chr17

28030080

-
5UTR-intronENST00000479829ENST00000582084MED24chr17

38209551

-SSH2chr17

28030080

-
5UTR-intronENST00000479829ENST00000590153MED24chr17

38209551

-SSH2chr17

28030080

-
Frame-shiftENST00000356271ENST00000269033MED24chr17

38209551

-SSH2chr17

28030080

-
Frame-shiftENST00000356271ENST00000540801MED24chr17

38209551

-SSH2chr17

28030080

-
Frame-shiftENST00000394126ENST00000269033MED24chr17

38209551

-SSH2chr17

28030080

-
Frame-shiftENST00000394126ENST00000540801MED24chr17

38209551

-SSH2chr17

28030080

-
Frame-shiftENST00000394128ENST00000269033MED24chr17

38209551

-SSH2chr17

28030080

-
Frame-shiftENST00000394128ENST00000540801MED24chr17

38209551

-SSH2chr17

28030080

-
Frame-shiftENST00000501516ENST00000269033MED24chr17

38209551

-SSH2chr17

28030080

-
Frame-shiftENST00000501516ENST00000540801MED24chr17

38209551

-SSH2chr17

28030080

-
In-frameENST00000394127ENST00000269033MED24chr17

38209551

-SSH2chr17

28030080

-
In-frameENST00000394127ENST00000540801MED24chr17

38209551

-SSH2chr17

28030080

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000394127MED24chr1738209551-ENST00000269033SSH2chr1728030080-938531730044811393
ENST00000394127MED24chr1738209551-ENST00000540801SSH2chr1728030080-457431730044811393

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000394127ENST00000269033MED24chr1738209551-SSH2chr1728030080-0.000493590.99950635
ENST00000394127ENST00000540801MED24chr1738209551-SSH2chr1728030080-0.0028758390.99712414

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Fusion Genomic Features for MED24-SSH2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MED24-SSH2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:38209551/chr17:28030080)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MED24

O75448

.
FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:16595664}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSSH2chr17:38209551chr17:28030080ENST00000269033115307_448351424.0DomainTyrosine-protein phosphatase

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMED24chr17:38209551chr17:28030080ENST00000356271-325128_13271977.0MotifNote=LXXLL motif 1
HgeneMED24chr17:38209551chr17:28030080ENST00000356271-325344_34871977.0MotifNote=LXXLL motif 2
HgeneMED24chr17:38209551chr17:28030080ENST00000356271-325448_45271977.0MotifNote=LXXLL motif 3
HgeneMED24chr17:38209551chr17:28030080ENST00000356271-325557_56171977.0MotifNote=LXXLL motif 4
HgeneMED24chr17:38209551chr17:28030080ENST00000356271-325788_79271977.0MotifNote=LXXLL motif 5
HgeneMED24chr17:38209551chr17:28030080ENST00000356271-325857_86171977.0MotifNote=LXXLL motif 6
HgeneMED24chr17:38209551chr17:28030080ENST00000394127-325128_13271977.0MotifNote=LXXLL motif 1
HgeneMED24chr17:38209551chr17:28030080ENST00000394127-325344_34871977.0MotifNote=LXXLL motif 2
HgeneMED24chr17:38209551chr17:28030080ENST00000394127-325448_45271977.0MotifNote=LXXLL motif 3
HgeneMED24chr17:38209551chr17:28030080ENST00000394127-325557_56171977.0MotifNote=LXXLL motif 4
HgeneMED24chr17:38209551chr17:28030080ENST00000394127-325788_79271977.0MotifNote=LXXLL motif 5
HgeneMED24chr17:38209551chr17:28030080ENST00000394127-325857_86171977.0MotifNote=LXXLL motif 6
HgeneMED24chr17:38209551chr17:28030080ENST00000394128-326128_13271990.0MotifNote=LXXLL motif 1
HgeneMED24chr17:38209551chr17:28030080ENST00000394128-326344_34871990.0MotifNote=LXXLL motif 2
HgeneMED24chr17:38209551chr17:28030080ENST00000394128-326448_45271990.0MotifNote=LXXLL motif 3
HgeneMED24chr17:38209551chr17:28030080ENST00000394128-326557_56171990.0MotifNote=LXXLL motif 4
HgeneMED24chr17:38209551chr17:28030080ENST00000394128-326788_79271990.0MotifNote=LXXLL motif 5
HgeneMED24chr17:38209551chr17:28030080ENST00000394128-326857_86171990.0MotifNote=LXXLL motif 6


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Fusion Gene Sequence for MED24-SSH2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>52721_52721_1_MED24-SSH2_MED24_chr17_38209551_ENST00000394127_SSH2_chr17_28030080_ENST00000269033_length(transcript)=9385nt_BP=317nt
AAGTGCCAAAATGGCGATGCCTACCACCTAGAACTGGATTGTGCGCTCCATTTCTTTCACCTCAAAGCTGGCCGCCACCGCTGCCACCTG
CTCAGAGTGAAATAATGAAGGTGGTCAACCTGAAGCAAGCCATTTTGCAAGCCTGGAAGGAGCGCTGGAGTGACTACCAATGGGCAATCA
ACATGAAGAAATTCTTTCCTAAAGGAGCCACCTGGGATATTCTCAACCTGGCAGATGCGTTACTAGAGCAGGCCATGATTGGACCATCCC
CCAATCCTCTCATCTTGTCCTACCTGAAGTATGCCATTAGTTCCCAGCATCAGCGAGAGCTTTCTAACTGTCAAAGGTGCTGCCCTTTTT
CTACCACGGGGAAATGGCTCATCCACACCAAGAATCAGCCACAGACGGAACAAGCATGCAGGCGATCTCCAACAGCATCTCCAAGCAATG
TTCATTTTACTCCGCCCAGAAGACAACATCAGGCTGGCTGTAAGACTGGAAAGTACTTACCAGAATCGAACACGCTATATGGTAGTGGTT
TCAACTAATGGTAGACAAGACACTGAAGAAAGCATCGTCCTAGGAATGGATTTCTCCTCTAATGACAGTAGCACTTGTACCATGGGCTTA
GTTTTGCCTCTCTGGAGCGACACGCTAATTCATTTGGATGGTGATGGTGGGTTCAGTGTATCGACGGATAACAGAGTTCACATATTCAAA
CCTGTATCTGTGCAGGCAATGTGGTCTGCACTACAGAGCTTACACAAGGCTTGTGAAGTCGCCAGAGCGCATAACTACTACCCAGGCAGC
CTATTTCTCACTTGGGTGAGTTATTATGAGAGCCATATCAACTCAGATCAATCCTCAGTCAATGAATGGAATGCAATGCAAGATGTACAG
TCCCACCGGCCCGACTCTCCAGCTCTCTTCACCGACATACCTACTGAACGTGAACGAACAGAAAGGCTAATTAAAACCAAATTAAGGGAG
ATCATGATGCAGAAGGATTTGGAGAATATTACATCCAAAGAGATAAGAACAGAGTTGGAAATGCAAATGGTGTGCAACTTGCGGGAATTC
AAGGAATTTATAGACAATGAAATGATAGTGATCCTTGGTCAAATGGATAGCCCTACACAGATATTTGAGCATGTGTTCCTGGGCTCAGAA
TGGAATGCCTCCAACTTAGAGGACTTACAGAACCGAGGGGTACGGTATATCTTGAATGTCACTCGAGAGATAGATAACTTCTTCCCAGGA
GTCTTTGAGTATCATAACATTCGGGTATATGATGAAGAGGCAACGGATCTCCTGGCGTACTGGAATGACACTTACAAATTCATCTCTAAA
GCAAAGAAACATGGATCTAAATGCCTTGTGCACTGCAAAATGGGGGTGAGTCGCTCAGCCTCCACCGTGATTGCCTATGCAATGAAGGAA
TATGGCTGGAATCTGGACCGAGCCTATGACTATGTGAAAGAAAGACGAACGGTAACCAAGCCCAACCCAAGCTTCATGAGACAACTGGAA
GAGTATCAGGGGATCTTGCTGGCAAGCAAACAGCGGCATAACAAACTATGGAGATCTCATTCAGATAGTGACCTCTCAGACCACCACGAA
CCCATCTGCAAACCTGGGCTAGAACTCAACAAGAAGGATATCACCACCTCAGCAGACCAGATTGCTGAGGTGAAGACCATGGAGAGTCAC
CCACCCATACCTCCTGTCTTTGTGGAACATATGGTCCCACAAGATGCAAATCAGAAAGGCCTGTGTACCAAAGAAAGAATGATCTGCTTG
GAGTTTACTTCTAGGGAATTTCATGCTGGACAGATTGAGGATGAATTAAACTTAAATGACATCAATGGATGCTCATCAGGGTGTTGTCTG
AATGAATCAAAATTTCCTCTTGACAATTGCCATGCATCCAAAGCCTTAATTCAGCCTGGACATGTCCCAGAAATGGCCAACAAGTTTCCA
GACTTAACAGTGGAAGATTTGGAGACAGATGCACTGAAAGCAGACATGAATGTCCACCTACTGCCTATGGAAGAATTGACATCTCCACTG
AAAGACCCCCCCATGTCCCCTGATCCTGAGTCACCAAGCCCCCAACCCAGTTGCCAGACTGAAATCTCAGATTTCAGTACAGATCGCATT
GACTTTTTTAGTGCCCTAGAGAAGTTTGTGGAGCTCTCCCAAGAAACCCGGTCACGATCTTTTTCCCATTCAAGGATGGAGGAACTGGGT
GGAGGAAGGAATGAGAGCTGTCGACTGTCAGTGGTAGAAGTAGCCCCTTCCAAAGTGACAGCTGATGACCAGAGAAGCAGCTCTTTGAGT
AATACTCCCCATGCATCAGAAGAATCTTCAATGGATGAGGAACAGTCAAAGGCAATTTCAGAACTGGTCAGCCCAGACATCTTCATGCAG
TCTCACTCGGAAAATGCAATTTCAGTCAAAGAAATTGTCACTGAAATTGAGTCCATCAGTCAAGGAGTTGGGCAGATTCAACTGAAAGGA
GACATCTTACCCAACCCATGCCATACACCAAAGAAGAACAGCATCCATGAGCTGCTCCTTGAGAGGGCCCAGACTCCAGAGAACAAACCT
GGACATATGGAGCAAGATGAGGACTCCTGCACAGCCCAGCCTGAACTAGCCAAAGACTCAGGGATGTGCAACCCAGAAGGCTGCCTAACC
ACACACTCATCTATAGCAGACTTGGAAGAAGGGGAACCAGCTGAGGGGGAACAAGAGCTCCAGGGCTCAGGGATGCACCCAGGTGCCAAG
TGGTACCCTGGGTCTGTGAGGCGAGCCACCTTGGAGTTCGAAGAGCGCTTACGGCAGGAGCAAGAGCATCATGGTGCTGCCCCAACATGT
ACCTCATTGTCCACTCGTAAGAATTCAAAGAATGATTCTTCTGTGGCAGACCTAGCACCAAAAGGGAAAAGTGATGAAGCCCCCCCAGAA
CATTCATTTGTCCTCAAGGAACCAGAAATGAGCAAAGGCAAAGGGAAATACAGTGGGTCTGAGGCTGGCTCACTGTCCCATTCTGAGCAG
AATGCCACTGTTCCAGCTCCCAGGGTGCTGGAGTTTGACCACTTGCCAGATCCTCAGGAGGGCCCAGGGTCAGATACTGGAACACAGCAG
GAAGGAGTCCTGAAGGATCTGAGGACTGTGATTCCATACCAGGAGTCTGAAACACAAGCAGTCCCTCTTCCCCTTCCCAAGAGGGTAGAA
ATCATTGAATATACCCACATAGTTACATCACCCAATCACACTGGGCCAGGGAGTGAAATAGCCACCAGTGAGAAGAGCGGAGAGCAAGGG
CTGAGGAAAGTGAACATGGAAAAATCTGTCACTGTGCTCTGCACACTGGATGAAAATCTAAACAGGACTCTGGACCCCAACCAGGTTTCT
CTGCACCCCCAAGTGCTACCTCTGCCTCATTCTTCCTCCCCTGAGCACAACAGACCCACTGACCATCCAACCTCCATCCTGAGTAGCCCT
GAAGACAGAGGCAGCAGCCTGTCCACAGCCCTGGAGACAGCAGCACCTTTTGTCAGTCATACAACCCATTTACTGTCTGCCAGTTTGGAT
TACCTGCATCCCCAGACTATGGTTCACCTGGAGGGCTTCACAGAGCAGAGCAGCACTACAGATGAGCCCTCTGCAGAACAGGTTAGCTGG
GAAGAAAGTCAGGAGAGCCCTCTCTCCAGTGGCAGTGAGGTGCCATATAAGGACTCCCAGCTAAGTAGCGCAGACCTAAGTTTAATTAGC
AAACTTGGTGACAACACTGGGGAGTTACAGGAGAAAATGGACCCATTGCCTGTAGCCTGTCGACTCCCACATAGCTCTAGTAGTGAAAAC
ATAAAGAGTCTCAGCCACAGCCCCGGTGTGGTGAAGGAGCGTGCTAAAGAAATCGAGTCTCGAGTGGTTTTCCAGGCAGGGCTCACCAAA
CCATCCCAAATGAGGCGCTCAGCTTCTCTCGCCAAATTAGGTTACTTGGACCTCTGTAAAGACTGCTTACCAGAGAGGGAGCCTGCCTCC
TGTGAATCCCCTCATCTCAAACTGCTTCAGCCTTTCCTCAGAACAGACTCAGGCATGCACGCGATGGAGGACCAAGAGTCCCTAGAAAAC
CCAGGTGCCCCCCACAACCCAGAGCCCACCAAGTCTTTTGTAGAACAACTCACAACAACAGAGTGTATTGTGCAGAGCAAGCCAGTGGAG
AGGCCCCTTGTGCAGTATGCCAAAGAATTTGGTTCTAGTCAGCAGTATTTGCTCCCCAGGGCAGGACTTGAATTGACTAGTTCTGAAGGA
GGCCTTCCCGTGCTACAGACCCAGGGACTGCAGTGTGCATGCCCAGCTCCAGGGCTGGCCGTGGCACCCCGTCAGCAACACGGCAGAACT
CACCCCCTTAGGAGACTGAAAAAGGCAAATGACAAAAAACGGACAACCAACCCCTTCTATAATACCATGTGATTCTGAGCCTACACATGT
GACTTTCTAGAAGAAATGTTTGTAAAAGGGGCAGGTGTAATATGTAAGGAACATGCACTTTATTGGTTAATTTTATAATATTTTGGTCAT
TTTACTGTTTCTGGTGCATGCAGGGTTTGGGTGTTTTTCAGTGTGTATGTGTGTGTATATGTAAGGGGAAAGAGAGATTGATCTGGATGG
CAAGACCGTTTATCATTTTTTATTTAAAAAAATCAAACCTCAAAAAAGTCATTTTCAGAGAACACCTTTATCAAAGGCAAATTGCTGTTT
TTCAGTCAGCTGCCACCTGCTTCTCATTTTGCCCTCTGAGAAAAGGCATGGTTTCTTAATTGAGGGAAGGAAGCAGATTCGGAGGGGTGG
AGATAAAGCTGGGGATTGGAGATGTTCCCCTGCCTTTGTGATGATGGTTTGGTTTCCAGACCTGAGGCATCGAATGGGCTAAAGGTCAGC
CAGAAGTCAGAGGGCTCTCAGCCTTCATCCAGCCGCAGCCCTTTAGAGTTCCTGAAGGAGGCAGGTTCCGCTTTGCTTTAAAAGAGGGTC
TTCCGGTGTTCCAGAGTGTATCGTTACAGTAAGACATGATAATGGCCGGCTCTGCAAATTTATCATATAGTTTTTTTCCCAAGAAAATTA
TTTTTGAAATTAAAACAGGACCCCAAATGAAATCCAAGTGGTCTTCTGTAGAGGAAAGCATGATAAGAGGAGGAAGACATAAAGTTGGGG
GTGGAGAGGCTGCTGCCCAGAAACTGCTGGGTTGGTGGGATCCACACAGATGGGCATCTTGGCTCTCCCTGCCAGAAAAATGTGCTCTGC
AGTGTCCTCCCAACTGAAAACAACAGTGACATGTTTGAAAAGCAGCAATCGAAAGTCAGTGTGTTCTTGTAAAATGAATATGTATGTAGG
GTTTTAACCCTTCCATTACTTGAATAATTCTTTGGGCCTTCTGAGTTTAATGGCCATATTTTCTTCCAGTTTATTTTCCTTCCCCATGCT
GTTGTCCCCATGCTGCCTATTTTTTTAAATTTCATAGATTATATTTGAATTGTTACATATGTTTAACATCCATTGAATGCAACGTTTTAT
TTTTGGTATTATCACTGTTAACACTTTTTTTTCCTTTTCCTGGAAGGTTTGTCATTTCTCTAAAGTTTGTACACAGTATTTATGTACATA
ATATTGTCACTGTCTTAGTGTCTTGTTCATGTTGTAGGGTAATTTTGATTTATTCTTTTTAAGAAGGAGTAGAGTTGCAACTGGAAAACA
CAGACACCAGAAATGAAAGTGTTGGGTGTTGATAGGAATCTGTACAATATGTTGATGGTGGCTGTAGTTGTTTAAATGGAGACTTCCAAT
CACCAGCTCCTGCCAAATTATGCATTAGTAACTTTTTCCTCAGAGACACCCCTAAAGGCTCCCATTAGGTCACAGCGTGACTGAAAGCTG
ATTTCTCTGTGAGACTGAAATCCCAGAACATTGTTTGCCAGTATCTCAACCACAGCCAGGAAGTATATGTGAGTTGCCCAGAGTGGAAGC
TCCTAGTAGAGGCTGAAGGCCACAGGGGAGGCCTCAGCCAGGGGCAAGTGCCCACAGTGACTCCATTTAGGATGCTGTCGTTTTGCTACT
GTTGTGGAGATCCTTAACGCAGCAGCGCCTGTCATAAACAAGCCTCTTGTAGCTTCTTACAGAAAACAGATTTAGTCTAGCATGAAACAC
CTCTGCATCTCATTGAAACTGAAGAGGCTTGCAGATTTGCTTTCGTTGATGTCCACGTTACTGAGGATTGACTGAGTATAGACTGGAGAC
AGGTTTTTGGCTTATCACAGCACTGAGGAAAATACAAATGCACAGACTGTCAGCATGATGTCAGAGGCCAGAGTTTGGTGGGGGCAGATG
GCAGGGCGACCCAAAAGATGCAGAAAAGGTAGACTGGGGCCACTGGGTCTTAAGAGGAGCTGTGAAGTTGTGTGGAAGCCAAGGCTGGGT
CTGACATCCCTGCCAGGAAGCAGGTTGGACAGAAACCACTTGCTAAAAGCGTCTCTATGGTGCAGTGATTATGTGTACCCTGTGCTGTTG
CTCAGTAGTCTCCTTGAATGTTCAAGTATCTCATCCACTCAGTTTTGTGATTCCTGGATATTTGTGTGTTGTAAAGTGTTTTGTTAGGTG
GTATGAACCAATGTGAGGAGGCTTGAGACAGGGTTATGGATTTCCAGAGCTCTTCCATGTAGAATACCCTGCCTTCTTGAAGCAGTTCCA
CCACCAATATGATGGGGAAGGGCAGGAACTTATGGCAGGGTGGGGAGAGGGTTTGCCTGGAAGTTAAGAGAGTGGCATCCACTTGTGGTA
ACCCCTTACGATGATGACATCCCACACACTAAGAGGTACAAGCAGGACCAAAGTTTTGGACTGTTCCCTCTTCTCCCCTCCACTGTGTTT
AATGTTCACTCACTGCATTAAATAACAACAAAGATGGGACAAAACCCACTAATACTGTGGGGAAAAAAAATTTTCAAGAGCAGAGGAAAG
TCTTTCTGCCTTTTTATAATTACTTTTTTTATCATTTAATTTACCTGCCTAAATAAACATCTTCTACAGAATATCTGTCATTCAACCATG
CCAAGGAGTTTGTGCCAGCCTTTTCAGACTCCCAGAATTGGGTGTTCCTGGGTTATTTACATAGCTGAGCAGTGTCCAGGGGAGGTGCGC
AGTGAACTGTCAAGGACTTTCCAGACTGTCTTCTCTTCAGACTTTTATAATCTCCAGTGGCATCTTTCCCTTTTCTTTTGTTCATGACCT
GACCTGAAGCAGCAGATTTGATAGACTGGCAAAGATGAATAGGAAAAACTTTGACTCTTGCCCAGTGCCTGCCTGCCTCTCTCTCTCTCC
TCTCTCTCTCTCTCTTTTTAAACCACCATAGACTCTCACTTATTTTGGAGGAGTGTATGTGCATGTGTACACATATGTACATATATAAAA
ACAGTTGATGTTTTGGTGTATGGGGTAAAAGCCCCAGGAGCATACAGAACTTGAGCTGAACCTGGTCAGTAGAAAGGGAAACCCCAACCC
TTTCTTGATTTTTGGAGACACCCAGGACTAATGGATACTGTAGTAGACATGTAGTACTATAGTACCGTAATATTCATCTCTCCTCATTTT
AGTTGCCTTTCAGATTCTAAATGTTTGGGATCATTCCTATCATCTTAGTCTCTTCAGGATCTTTAGTATTTTCCTGGTTCTGAGGAGGCT
TGAGACAGGGTTATGGATTTCCTTGTTCTGTGTCTTTATCCCTACTGATAGTTCCTCTTTCTCATTTTGCAAACTACCCAGAGCTCCAAG
GACAGCCTGAAGATCTCAGTGCCTCAGGCTCTGAGGTACTCTGCTCACAGGCCCCAGACAGATGCTGTTGGGTAAACTCAAAGCTTCCTA
TGAGAAGCTTCTGAGATGTAGCAGGTCACAGAAGTGTTCACCTGTTTCATCTGAGGATTTCAGTTCTGAAGTGATCTAGGCATGTTTGGT
AAAAATGTTTTTGTGAGAGTTCTTTTTTTAAGAAAGCATTATGCAAAAAGTCACTTTTAAGGGCATTTAAAAATTTTTAAGTAAAGCCAT
TCTTTGGCTTTTTTGGACTATTTGTGGATACTTTGTTTACATTTTGAATATTAAAATGTGCATCATCTTGTCGGCCATGCAGTCCTGCAG
GCATCAGTGCCCTGGCTGTCCTGTGAGTCCTCATGCAGAGCAGGGCCATCATGGTCAGCCCTTGTGAGTAAGTGGGTATACGCTGAAGCT
GACTTCCGTCTGTGTCCTGCCCTCCCATCCAGCACTCTCTATGGAAATAGTTGTCATTTCCTCAGTGATGGTGTGTCTTATAGTGATGGT
TGTAATGGTGAATGGCTAGTGTCATTTTGTTTAATTTTGTTTTGCTTTTTGATGGTGGATAAGATGAAATTTTAGCTGTTTCAGCATCAA
TCCAACTTAAAAGCATCTTGGACTTTGTTTTCCCTTCCAAACTAAAAGATCAAGGCATGTATTAGACACAAGCATATTTGCTGCCTCAAC
TCCTCTGACACCCATATTAGGAAAAGGCCTGCCACCAAAGCAGGAAGCTGCACACTCCTAACCCTTCTCCCAGGGTGTGGGGTCCCTTGA
CGTCATGAAGAGCTATTGCAAGGTGCTTCTGTACTTTTCCAGCCTGGAAATGGAGGGTGACTGGCCCTGGCTCCTGCTATGAGAAGATAA
CCAGCCTCATTTTCTCAGTGCCCCAGAGGTCTAGGATAGGATTTCTAAACTGGAATCATCCTTAATCACCTTGAAGATCCCTTAAGAGGC
ATTTGACTGGTGCTGCCGTCTGTGTCCTCAAAGCAATGCTGGTGGCAGCGTCCTGTGTACACATGCAGAGCTAATACCCAAACTAAAAAC
TGGGTAACTGGCCCTGAAGTGCTTCCCAATCAGTAAGCCCACAGGGAAATGTTTGATTTTTATGTTCTGTTGGATTTTGGTTTGCTTGGC
ATATCTAAAGGTGCCTTTACTTTTCTTTTTTTTTTTTTTTCTTTCTGCTTTGTTTTGTAGGACTTGTTCTAACATGGAAAACAAGTCCAG
AAGACTCTCCTCTGACTGTTACCTTTGCCCCAAGCCACCCCAAACTTTTATGCTCATGTTTTATTAAAGCAGGTGCTCCCTGGAATCTCT
GGGACATTTTTGAGGCATTTGAAGCAGAATATAGAGTGGTCTCATCTCCTTCCTTAATCTTCCTGGTGGTTGGGATGTTCCACTTGTATC
ATAGATTTTTTTATTACAGATATGCTCCACTGTTTTTAAATGTGAACTTGTGCGCAAATGTGCAGATTCAATGTTCTTGTTACAGATTGA

>52721_52721_1_MED24-SSH2_MED24_chr17_38209551_ENST00000394127_SSH2_chr17_28030080_ENST00000269033_length(amino acids)=1393AA_BP=5
MPLVPSISESFLTVKGAALFLPRGNGSSTPRISHRRNKHAGDLQQHLQAMFILLRPEDNIRLAVRLESTYQNRTRYMVVVSTNGRQDTEE
SIVLGMDFSSNDSSTCTMGLVLPLWSDTLIHLDGDGGFSVSTDNRVHIFKPVSVQAMWSALQSLHKACEVARAHNYYPGSLFLTWVSYYE
SHINSDQSSVNEWNAMQDVQSHRPDSPALFTDIPTERERTERLIKTKLREIMMQKDLENITSKEIRTELEMQMVCNLREFKEFIDNEMIV
ILGQMDSPTQIFEHVFLGSEWNASNLEDLQNRGVRYILNVTREIDNFFPGVFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSKCLV
HCKMGVSRSASTVIAYAMKEYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQGILLASKQRHNKLWRSHSDSDLSDHHEPICKPGLELN
KKDITTSADQIAEVKTMESHPPIPPVFVEHMVPQDANQKGLCTKERMICLEFTSREFHAGQIEDELNLNDINGCSSGCCLNESKFPLDNC
HASKALIQPGHVPEMANKFPDLTVEDLETDALKADMNVHLLPMEELTSPLKDPPMSPDPESPSPQPSCQTEISDFSTDRIDFFSALEKFV
ELSQETRSRSFSHSRMEELGGGRNESCRLSVVEVAPSKVTADDQRSSSLSNTPHASEESSMDEEQSKAISELVSPDIFMQSHSENAISVK
EIVTEIESISQGVGQIQLKGDILPNPCHTPKKNSIHELLLERAQTPENKPGHMEQDEDSCTAQPELAKDSGMCNPEGCLTTHSSIADLEE
GEPAEGEQELQGSGMHPGAKWYPGSVRRATLEFEERLRQEQEHHGAAPTCTSLSTRKNSKNDSSVADLAPKGKSDEAPPEHSFVLKEPEM
SKGKGKYSGSEAGSLSHSEQNATVPAPRVLEFDHLPDPQEGPGSDTGTQQEGVLKDLRTVIPYQESETQAVPLPLPKRVEIIEYTHIVTS
PNHTGPGSEIATSEKSGEQGLRKVNMEKSVTVLCTLDENLNRTLDPNQVSLHPQVLPLPHSSSPEHNRPTDHPTSILSSPEDRGSSLSTA
LETAAPFVSHTTHLLSASLDYLHPQTMVHLEGFTEQSSTTDEPSAEQVSWEESQESPLSSGSEVPYKDSQLSSADLSLISKLGDNTGELQ
EKMDPLPVACRLPHSSSSENIKSLSHSPGVVKERAKEIESRVVFQAGLTKPSQMRRSASLAKLGYLDLCKDCLPEREPASCESPHLKLLQ
PFLRTDSGMHAMEDQESLENPGAPHNPEPTKSFVEQLTTTECIVQSKPVERPLVQYAKEFGSSQQYLLPRAGLELTSSEGGLPVLQTQGL

--------------------------------------------------------------
>52721_52721_2_MED24-SSH2_MED24_chr17_38209551_ENST00000394127_SSH2_chr17_28030080_ENST00000540801_length(transcript)=4574nt_BP=317nt
AAGTGCCAAAATGGCGATGCCTACCACCTAGAACTGGATTGTGCGCTCCATTTCTTTCACCTCAAAGCTGGCCGCCACCGCTGCCACCTG
CTCAGAGTGAAATAATGAAGGTGGTCAACCTGAAGCAAGCCATTTTGCAAGCCTGGAAGGAGCGCTGGAGTGACTACCAATGGGCAATCA
ACATGAAGAAATTCTTTCCTAAAGGAGCCACCTGGGATATTCTCAACCTGGCAGATGCGTTACTAGAGCAGGCCATGATTGGACCATCCC
CCAATCCTCTCATCTTGTCCTACCTGAAGTATGCCATTAGTTCCCAGCATCAGCGAGAGCTTTCTAACTGTCAAAGGTGCTGCCCTTTTT
CTACCACGGGGAAATGGCTCATCCACACCAAGAATCAGCCACAGACGGAACAAGCATGCAGGCGATCTCCAACAGCATCTCCAAGCAATG
TTCATTTTACTCCGCCCAGAAGACAACATCAGGCTGGCTGTAAGACTGGAAAGTACTTACCAGAATCGAACACGCTATATGGTAGTGGTT
TCAACTAATGGTAGACAAGACACTGAAGAAAGCATCGTCCTAGGAATGGATTTCTCCTCTAATGACAGTAGCACTTGTACCATGGGCTTA
GTTTTGCCTCTCTGGAGCGACACGCTAATTCATTTGGATGGTGATGGTGGGTTCAGTGTATCGACGGATAACAGAGTTCACATATTCAAA
CCTGTATCTGTGCAGGCAATGTGGTCTGCACTACAGAGCTTACACAAGGCTTGTGAAGTCGCCAGAGCGCATAACTACTACCCAGGCAGC
CTATTTCTCACTTGGGTGAGTTATTATGAGAGCCATATCAACTCAGATCAATCCTCAGTCAATGAATGGAATGCAATGCAAGATGTACAG
TCCCACCGGCCCGACTCTCCAGCTCTCTTCACCGACATACCTACTGAACGTGAACGAACAGAAAGGCTAATTAAAACCAAATTAAGGGAG
ATCATGATGCAGAAGGATTTGGAGAATATTACATCCAAAGAGATAAGAACAGAGTTGGAAATGCAAATGGTGTGCAACTTGCGGGAATTC
AAGGAATTTATAGACAATGAAATGATAGTGATCCTTGGTCAAATGGATAGCCCTACACAGATATTTGAGCATGTGTTCCTGGGCTCAGAA
TGGAATGCCTCCAACTTAGAGGACTTACAGAACCGAGGGGTACGGTATATCTTGAATGTCACTCGAGAGATAGATAACTTCTTCCCAGGA
GTCTTTGAGTATCATAACATTCGGGTATATGATGAAGAGGCAACGGATCTCCTGGCGTACTGGAATGACACTTACAAATTCATCTCTAAA
GCAAAGAAACATGGATCTAAATGCCTTGTGCACTGCAAAATGGGGGTGAGTCGCTCAGCCTCCACCGTGATTGCCTATGCAATGAAGGAA
TATGGCTGGAATCTGGACCGAGCCTATGACTATGTGAAAGAAAGACGAACGGTAACCAAGCCCAACCCAAGCTTCATGAGACAACTGGAA
GAGTATCAGGGGATCTTGCTGGCAAGCAAACAGCGGCATAACAAACTATGGAGATCTCATTCAGATAGTGACCTCTCAGACCACCACGAA
CCCATCTGCAAACCTGGGCTAGAACTCAACAAGAAGGATATCACCACCTCAGCAGACCAGATTGCTGAGGTGAAGACCATGGAGAGTCAC
CCACCCATACCTCCTGTCTTTGTGGAACATATGGTCCCACAAGATGCAAATCAGAAAGGCCTGTGTACCAAAGAAAGAATGATCTGCTTG
GAGTTTACTTCTAGGGAATTTCATGCTGGACAGATTGAGGATGAATTAAACTTAAATGACATCAATGGATGCTCATCAGGGTGTTGTCTG
AATGAATCAAAATTTCCTCTTGACAATTGCCATGCATCCAAAGCCTTAATTCAGCCTGGACATGTCCCAGAAATGGCCAACAAGTTTCCA
GACTTAACAGTGGAAGATTTGGAGACAGATGCACTGAAAGCAGACATGAATGTCCACCTACTGCCTATGGAAGAATTGACATCTCCACTG
AAAGACCCCCCCATGTCCCCTGATCCTGAGTCACCAAGCCCCCAACCCAGTTGCCAGACTGAAATCTCAGATTTCAGTACAGATCGCATT
GACTTTTTTAGTGCCCTAGAGAAGTTTGTGGAGCTCTCCCAAGAAACCCGGTCACGATCTTTTTCCCATTCAAGGATGGAGGAACTGGGT
GGAGGAAGGAATGAGAGCTGTCGACTGTCAGTGGTAGAAGTAGCCCCTTCCAAAGTGACAGCTGATGACCAGAGAAGCAGCTCTTTGAGT
AATACTCCCCATGCATCAGAAGAATCTTCAATGGATGAGGAACAGTCAAAGGCAATTTCAGAACTGGTCAGCCCAGACATCTTCATGCAG
TCTCACTCGGAAAATGCAATTTCAGTCAAAGAAATTGTCACTGAAATTGAGTCCATCAGTCAAGGAGTTGGGCAGATTCAACTGAAAGGA
GACATCTTACCCAACCCATGCCATACACCAAAGAAGAACAGCATCCATGAGCTGCTCCTTGAGAGGGCCCAGACTCCAGAGAACAAACCT
GGACATATGGAGCAAGATGAGGACTCCTGCACAGCCCAGCCTGAACTAGCCAAAGACTCAGGGATGTGCAACCCAGAAGGCTGCCTAACC
ACACACTCATCTATAGCAGACTTGGAAGAAGGGGAACCAGCTGAGGGGGAACAAGAGCTCCAGGGCTCAGGGATGCACCCAGGTGCCAAG
TGGTACCCTGGGTCTGTGAGGCGAGCCACCTTGGAGTTCGAAGAGCGCTTACGGCAGGAGCAAGAGCATCATGGTGCTGCCCCAACATGT
ACCTCATTGTCCACTCGTAAGAATTCAAAGAATGATTCTTCTGTGGCAGACCTAGCACCAAAAGGGAAAAGTGATGAAGCCCCCCCAGAA
CATTCATTTGTCCTCAAGGAACCAGAAATGAGCAAAGGCAAAGGGAAATACAGTGGGTCTGAGGCTGGCTCACTGTCCCATTCTGAGCAG
AATGCCACTGTTCCAGCTCCCAGGGTGCTGGAGTTTGACCACTTGCCAGATCCTCAGGAGGGCCCAGGGTCAGATACTGGAACACAGCAG
GAAGGAGTCCTGAAGGATCTGAGGACTGTGATTCCATACCAGGAGTCTGAAACACAAGCAGTCCCTCTTCCCCTTCCCAAGAGGGTAGAA
ATCATTGAATATACCCACATAGTTACATCACCCAATCACACTGGGCCAGGGAGTGAAATAGCCACCAGTGAGAAGAGCGGAGAGCAAGGG
CTGAGGAAAGTGAACATGGAAAAATCTGTCACTGTGCTCTGCACACTGGATGAAAATCTAAACAGGACTCTGGACCCCAACCAGGTTTCT
CTGCACCCCCAAGTGCTACCTCTGCCTCATTCTTCCTCCCCTGAGCACAACAGACCCACTGACCATCCAACCTCCATCCTGAGTAGCCCT
GAAGACAGAGGCAGCAGCCTGTCCACAGCCCTGGAGACAGCAGCACCTTTTGTCAGTCATACAACCCATTTACTGTCTGCCAGTTTGGAT
TACCTGCATCCCCAGACTATGGTTCACCTGGAGGGCTTCACAGAGCAGAGCAGCACTACAGATGAGCCCTCTGCAGAACAGGTTAGCTGG
GAAGAAAGTCAGGAGAGCCCTCTCTCCAGTGGCAGTGAGGTGCCATATAAGGACTCCCAGCTAAGTAGCGCAGACCTAAGTTTAATTAGC
AAACTTGGTGACAACACTGGGGAGTTACAGGAGAAAATGGACCCATTGCCTGTAGCCTGTCGACTCCCACATAGCTCTAGTAGTGAAAAC
ATAAAGAGTCTCAGCCACAGCCCCGGTGTGGTGAAGGAGCGTGCTAAAGAAATCGAGTCTCGAGTGGTTTTCCAGGCAGGGCTCACCAAA
CCATCCCAAATGAGGCGCTCAGCTTCTCTCGCCAAATTAGGTTACTTGGACCTCTGTAAAGACTGCTTACCAGAGAGGGAGCCTGCCTCC
TGTGAATCCCCTCATCTCAAACTGCTTCAGCCTTTCCTCAGAACAGACTCAGGCATGCACGCGATGGAGGACCAAGAGTCCCTAGAAAAC
CCAGGTGCCCCCCACAACCCAGAGCCCACCAAGTCTTTTGTAGAACAACTCACAACAACAGAGTGTATTGTGCAGAGCAAGCCAGTGGAG
AGGCCCCTTGTGCAGTATGCCAAAGAATTTGGTTCTAGTCAGCAGTATTTGCTCCCCAGGGCAGGACTTGAATTGACTAGTTCTGAAGGA
GGCCTTCCCGTGCTACAGACCCAGGGACTGCAGTGTGCATGCCCAGCTCCAGGGCTGGCCGTGGCACCCCGTCAGCAACACGGCAGAACT
CACCCCCTTAGGAGACTGAAAAAGGCAAATGACAAAAAACGGACAACCAACCCCTTCTATAATACCATGTGATTCTGAGCCTACACATGT

>52721_52721_2_MED24-SSH2_MED24_chr17_38209551_ENST00000394127_SSH2_chr17_28030080_ENST00000540801_length(amino acids)=1393AA_BP=5
MPLVPSISESFLTVKGAALFLPRGNGSSTPRISHRRNKHAGDLQQHLQAMFILLRPEDNIRLAVRLESTYQNRTRYMVVVSTNGRQDTEE
SIVLGMDFSSNDSSTCTMGLVLPLWSDTLIHLDGDGGFSVSTDNRVHIFKPVSVQAMWSALQSLHKACEVARAHNYYPGSLFLTWVSYYE
SHINSDQSSVNEWNAMQDVQSHRPDSPALFTDIPTERERTERLIKTKLREIMMQKDLENITSKEIRTELEMQMVCNLREFKEFIDNEMIV
ILGQMDSPTQIFEHVFLGSEWNASNLEDLQNRGVRYILNVTREIDNFFPGVFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSKCLV
HCKMGVSRSASTVIAYAMKEYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQGILLASKQRHNKLWRSHSDSDLSDHHEPICKPGLELN
KKDITTSADQIAEVKTMESHPPIPPVFVEHMVPQDANQKGLCTKERMICLEFTSREFHAGQIEDELNLNDINGCSSGCCLNESKFPLDNC
HASKALIQPGHVPEMANKFPDLTVEDLETDALKADMNVHLLPMEELTSPLKDPPMSPDPESPSPQPSCQTEISDFSTDRIDFFSALEKFV
ELSQETRSRSFSHSRMEELGGGRNESCRLSVVEVAPSKVTADDQRSSSLSNTPHASEESSMDEEQSKAISELVSPDIFMQSHSENAISVK
EIVTEIESISQGVGQIQLKGDILPNPCHTPKKNSIHELLLERAQTPENKPGHMEQDEDSCTAQPELAKDSGMCNPEGCLTTHSSIADLEE
GEPAEGEQELQGSGMHPGAKWYPGSVRRATLEFEERLRQEQEHHGAAPTCTSLSTRKNSKNDSSVADLAPKGKSDEAPPEHSFVLKEPEM
SKGKGKYSGSEAGSLSHSEQNATVPAPRVLEFDHLPDPQEGPGSDTGTQQEGVLKDLRTVIPYQESETQAVPLPLPKRVEIIEYTHIVTS
PNHTGPGSEIATSEKSGEQGLRKVNMEKSVTVLCTLDENLNRTLDPNQVSLHPQVLPLPHSSSPEHNRPTDHPTSILSSPEDRGSSLSTA
LETAAPFVSHTTHLLSASLDYLHPQTMVHLEGFTEQSSTTDEPSAEQVSWEESQESPLSSGSEVPYKDSQLSSADLSLISKLGDNTGELQ
EKMDPLPVACRLPHSSSSENIKSLSHSPGVVKERAKEIESRVVFQAGLTKPSQMRRSASLAKLGYLDLCKDCLPEREPASCESPHLKLLQ
PFLRTDSGMHAMEDQESLENPGAPHNPEPTKSFVEQLTTTECIVQSKPVERPLVQYAKEFGSSQQYLLPRAGLELTSSEGGLPVLQTQGL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MED24-SSH2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MED24-SSH2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MED24-SSH2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource