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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MED24-STAC2 (FusionGDB2 ID:52722)

Fusion Gene Summary for MED24-STAC2

check button Fusion gene summary
Fusion gene informationFusion gene name: MED24-STAC2
Fusion gene ID: 52722
HgeneTgene
Gene symbol

MED24

STAC2

Gene ID

9862

342667

Gene namemediator complex subunit 24SH3 and cysteine rich domain 2
SynonymsARC100|CRSP100|CRSP4|DRIP100|MED5|THRAP4|TRAP10024b2|24b2/STAC2
Cytomap

17q21.1

17q12

Type of geneprotein-codingprotein-coding
Descriptionmediator of RNA polymerase II transcription subunit 24CRSP complex subunit 4activator-recruited cofactor 100 kDa componentcofactor required for Sp1 transcriptional activation subunit 4cofactor required for Sp1 transcriptional activation, subunit 4, 10SH3 and cysteine-rich domain-containing protein 2SRC homology 3 and cysteine-rich domain-containing protein 2
Modification date2020031320200313
UniProtAcc

O75448

.
Ensembl transtripts involved in fusion geneENST00000479829, ENST00000356271, 
ENST00000394127, ENST00000394128, 
ENST00000394126, ENST00000501516, 
ENST00000333461, 
Fusion gene scores* DoF score21 X 18 X 9=34029 X 6 X 6=324
# samples 2612
** MAII scorelog2(26/3402*10)=-3.70979961263493
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/324*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MED24 [Title/Abstract] AND STAC2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMED24(38209551)-STAC2(37369385), # samples:1
MED24(38209550)-STAC2(37369385), # samples:1
Anticipated loss of major functional domain due to fusion event.MED24-STAC2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
MED24-STAC2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
MED24-STAC2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMED24

GO:0006367

transcription initiation from RNA polymerase II promoter

12218053

HgeneMED24

GO:0045893

positive regulation of transcription, DNA-templated

10198638


check buttonFusion gene breakpoints across MED24 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across STAC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-AA6G-01AMED24chr17

38209551

-STAC2chr17

37369385

-
ChimerDB4STADTCGA-VQ-AA6GMED24chr17

38209550

-STAC2chr17

37369385

-


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Fusion Gene ORF analysis for MED24-STAC2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000479829ENST00000333461MED24chr17

38209551

-STAC2chr17

37369385

-
5UTR-3CDSENST00000479829ENST00000333461MED24chr17

38209550

-STAC2chr17

37369385

-
Frame-shiftENST00000356271ENST00000333461MED24chr17

38209551

-STAC2chr17

37369385

-
Frame-shiftENST00000356271ENST00000333461MED24chr17

38209550

-STAC2chr17

37369385

-
Frame-shiftENST00000394127ENST00000333461MED24chr17

38209551

-STAC2chr17

37369385

-
Frame-shiftENST00000394127ENST00000333461MED24chr17

38209550

-STAC2chr17

37369385

-
Frame-shiftENST00000394128ENST00000333461MED24chr17

38209551

-STAC2chr17

37369385

-
Frame-shiftENST00000394128ENST00000333461MED24chr17

38209550

-STAC2chr17

37369385

-
In-frameENST00000394126ENST00000333461MED24chr17

38209551

-STAC2chr17

37369385

-
In-frameENST00000394126ENST00000333461MED24chr17

38209550

-STAC2chr17

37369385

-
In-frameENST00000501516ENST00000333461MED24chr17

38209551

-STAC2chr17

37369385

-
In-frameENST00000501516ENST00000333461MED24chr17

38209550

-STAC2chr17

37369385

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000394126MED24chr1738209551-ENST00000333461STAC2chr1737369385-270670719002685261
ENST00000501516MED24chr1738209551-ENST00000333461STAC2chr1737369385-222222314162201261
ENST00000394126MED24chr1738209550-ENST00000333461STAC2chr1737369385-270670719002685261
ENST00000501516MED24chr1738209550-ENST00000333461STAC2chr1737369385-222222314162201261

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000394126ENST00000333461MED24chr1738209551-STAC2chr1737369385-0.0154794010.9845206
ENST00000501516ENST00000333461MED24chr1738209551-STAC2chr1737369385-0.073423410.92657655
ENST00000394126ENST00000333461MED24chr1738209550-STAC2chr1737369385-0.0154794010.9845206
ENST00000501516ENST00000333461MED24chr1738209550-STAC2chr1737369385-0.073423410.92657655

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Fusion Genomic Features for MED24-STAC2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MED24-STAC2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:38209551/chr17:37369385)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MED24

O75448

.
FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:16595664}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSTAC2chr17:38209550chr17:37369385ENST00000333461811354_411331412.0DomainSH3 2
TgeneSTAC2chr17:38209551chr17:37369385ENST00000333461811354_411331412.0DomainSH3 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMED24chr17:38209550chr17:37369385ENST00000356271-325128_13271977.0MotifNote=LXXLL motif 1
HgeneMED24chr17:38209550chr17:37369385ENST00000356271-325344_34871977.0MotifNote=LXXLL motif 2
HgeneMED24chr17:38209550chr17:37369385ENST00000356271-325448_45271977.0MotifNote=LXXLL motif 3
HgeneMED24chr17:38209550chr17:37369385ENST00000356271-325557_56171977.0MotifNote=LXXLL motif 4
HgeneMED24chr17:38209550chr17:37369385ENST00000356271-325788_79271977.0MotifNote=LXXLL motif 5
HgeneMED24chr17:38209550chr17:37369385ENST00000356271-325857_86171977.0MotifNote=LXXLL motif 6
HgeneMED24chr17:38209550chr17:37369385ENST00000394127-325128_13271977.0MotifNote=LXXLL motif 1
HgeneMED24chr17:38209550chr17:37369385ENST00000394127-325344_34871977.0MotifNote=LXXLL motif 2
HgeneMED24chr17:38209550chr17:37369385ENST00000394127-325448_45271977.0MotifNote=LXXLL motif 3
HgeneMED24chr17:38209550chr17:37369385ENST00000394127-325557_56171977.0MotifNote=LXXLL motif 4
HgeneMED24chr17:38209550chr17:37369385ENST00000394127-325788_79271977.0MotifNote=LXXLL motif 5
HgeneMED24chr17:38209550chr17:37369385ENST00000394127-325857_86171977.0MotifNote=LXXLL motif 6
HgeneMED24chr17:38209550chr17:37369385ENST00000394128-326128_13271990.0MotifNote=LXXLL motif 1
HgeneMED24chr17:38209550chr17:37369385ENST00000394128-326344_34871990.0MotifNote=LXXLL motif 2
HgeneMED24chr17:38209550chr17:37369385ENST00000394128-326448_45271990.0MotifNote=LXXLL motif 3
HgeneMED24chr17:38209550chr17:37369385ENST00000394128-326557_56171990.0MotifNote=LXXLL motif 4
HgeneMED24chr17:38209550chr17:37369385ENST00000394128-326788_79271990.0MotifNote=LXXLL motif 5
HgeneMED24chr17:38209550chr17:37369385ENST00000394128-326857_86171990.0MotifNote=LXXLL motif 6
HgeneMED24chr17:38209551chr17:37369385ENST00000356271-325128_13271977.0MotifNote=LXXLL motif 1
HgeneMED24chr17:38209551chr17:37369385ENST00000356271-325344_34871977.0MotifNote=LXXLL motif 2
HgeneMED24chr17:38209551chr17:37369385ENST00000356271-325448_45271977.0MotifNote=LXXLL motif 3
HgeneMED24chr17:38209551chr17:37369385ENST00000356271-325557_56171977.0MotifNote=LXXLL motif 4
HgeneMED24chr17:38209551chr17:37369385ENST00000356271-325788_79271977.0MotifNote=LXXLL motif 5
HgeneMED24chr17:38209551chr17:37369385ENST00000356271-325857_86171977.0MotifNote=LXXLL motif 6
HgeneMED24chr17:38209551chr17:37369385ENST00000394127-325128_13271977.0MotifNote=LXXLL motif 1
HgeneMED24chr17:38209551chr17:37369385ENST00000394127-325344_34871977.0MotifNote=LXXLL motif 2
HgeneMED24chr17:38209551chr17:37369385ENST00000394127-325448_45271977.0MotifNote=LXXLL motif 3
HgeneMED24chr17:38209551chr17:37369385ENST00000394127-325557_56171977.0MotifNote=LXXLL motif 4
HgeneMED24chr17:38209551chr17:37369385ENST00000394127-325788_79271977.0MotifNote=LXXLL motif 5
HgeneMED24chr17:38209551chr17:37369385ENST00000394127-325857_86171977.0MotifNote=LXXLL motif 6
HgeneMED24chr17:38209551chr17:37369385ENST00000394128-326128_13271990.0MotifNote=LXXLL motif 1
HgeneMED24chr17:38209551chr17:37369385ENST00000394128-326344_34871990.0MotifNote=LXXLL motif 2
HgeneMED24chr17:38209551chr17:37369385ENST00000394128-326448_45271990.0MotifNote=LXXLL motif 3
HgeneMED24chr17:38209551chr17:37369385ENST00000394128-326557_56171990.0MotifNote=LXXLL motif 4
HgeneMED24chr17:38209551chr17:37369385ENST00000394128-326788_79271990.0MotifNote=LXXLL motif 5
HgeneMED24chr17:38209551chr17:37369385ENST00000394128-326857_86171990.0MotifNote=LXXLL motif 6
TgeneSTAC2chr17:38209550chr17:37369385ENST0000033346181170_101331412.0Compositional biasNote=Pro-rich
TgeneSTAC2chr17:38209551chr17:37369385ENST0000033346181170_101331412.0Compositional biasNote=Pro-rich
TgeneSTAC2chr17:38209550chr17:37369385ENST00000333461811292_351331412.0DomainSH3 1
TgeneSTAC2chr17:38209551chr17:37369385ENST00000333461811292_351331412.0DomainSH3 1
TgeneSTAC2chr17:38209550chr17:37369385ENST00000333461811110_161331412.0Zinc fingerPhorbol-ester/DAG-type
TgeneSTAC2chr17:38209551chr17:37369385ENST00000333461811110_161331412.0Zinc fingerPhorbol-ester/DAG-type


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Fusion Gene Sequence for MED24-STAC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>52722_52722_1_MED24-STAC2_MED24_chr17_38209550_ENST00000394126_STAC2_chr17_37369385_ENST00000333461_length(transcript)=2706nt_BP=707nt
GGTGCGATCTCGGCTCACCCCAACAACCTCCGCCTCCCGGGTTCAAGCGATTCTACTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGC
ATGCACCACCAAGCCCGGCTAATTTTGTATTTTTAGTGGAGACGAGGTTTCTCCATGTTGGTCAGGCTAGTCTCGAACTCCTGACCTCCG
GTGATTCGCCCGCCTCTGCCTCCCGAAGTGCTGGGATTACAGGTGCGAGCCACTGCGCTCGGCCGATACTTTCTTAGTGCCCCAGTTTAA
GGAAGGGCGGTTCAGGAGGAGAGAGTCTGACAGGATCTTACTTTATCCCTTTAGCTCTTTTTCTTTCAAATTCCTCTGTCTCGCTTAAAT
CTTCCCGCATCTTCTCCTTTCTATTTAATTCTGCCTTCCCCGGTTCTCCTTAGAACCTCATGTCCTTTTCTTTAGCTCCATTTCTTTCAC
CTCAAAGCTGGCCGCCACCGCTGCCACCTGCTCAGAGTGAAATAATGAAGGTGGTCAACCTGAAGCAAGCCATTTTGCAAGCCTGGAAGG
AGCGCTGGAGTGACTACCAATGGGCAATCAACATGAAGAAATTCTTTCCTAAAGGAGCCACCTGGGATATTCTCAACCTGGCAGATGCGT
TACTAGAGCAGGCCATGATTGGACCATCCCCCAATCCTCTCATCTTGTCCTACCTGAAGTATGCCATTAGTTCCCAGGGCAAGATCGGCG
ACCGGGTTGGCTTCTTCCCAGCTAATTTTGTGCAACGGGTGAGGCCAGGCGAGAATGTTTGGCGCTGCTGCCAACCCTTCTCCGGGAACA
AGGAACAGGGTTACATGAGCCTCAAGGAGAACCAGATCTGCGTGGGCGTGGGCAGAAGCAAGGATGCTGACGGCTTCATCCGCGTCAGCA
GTGGCAAGAAGCGGGGCCTGGTGCCAGTCGACGCCCTGACTGAGATCTGAGAGGAGCCAAGGGAACCCAGATGACACCCTTGCCCATGCC
TGGACCTTGCTTCTGGCCAGGGAGGGGATCAGGCCCCCTTGTCCACTCCATACCCTTCCTCCCTCTGTCCCTCTCCTAGGTGCCACTTAC
CGTGGCTTAGGAGCCTTTTGTACTGGGGAAGATTTTATTTCTTGGGTGGGGTGCCCTGAGTGGGTTGATCCTCTGGGACTTGGCGGGGAT
GGGGTGGGGTGGGAGGGAATGAGGAAGCTACAGGTAGGTCCACCCAACGCCCAGGCACCCCAGTCTACTTGCTGGGCTGAGTCCAGCCCT
GGGGAAGATTCCTGGGGAATTTATTTGCTGCTTCTCCCAGCCTTCCCCTGCCCACACCACCTGCGCATGCCTGGCACACCCCTCTCCCCA
CAGAGCCTCTGCTTGGGTCTATGTGTGTGTGACCGTGCATCTGCTCCTTTGCAAGTGGGGTCTTGGGAGCAGGCCTTTTTGTGTCCTCGG
CCCTCCACCCTTGGTGGGGAGGGGACCCAGGACCATAGGAAGGTCCTGAGTCCACCTCCTGGTCTCCACCTCTGTCATTCCGTCAATTCT
CAGGAAAGTTTTGCAGGAATCTCTCCCGTTACTTGAAACCTGGGCGGACAGATGAGGGGAAGGCTGAGGTCCCTGGAAGGTGTAACAAAT
CAGAGACTATCTGTTCAAGTAGAAAACCCAAGAGCTGGCCAGGTGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTG
GGCAGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAGTACGAAACTTAGCCAGGCA
TGATGGGGGTCTGCCTGTAATGCCAGCTACTCCAGAGGCTGAGGCAAGAGAATCACTTGAACCCGGGAGGCGGAGGTTTCAGTGAGCCGA
GATTGCACCATTGCACCCCAGCCTGGGCAACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAGAAAGAAAGAAAAGGAAACCCAAGAGCT
GCCTGGACACACGGAAACCCAACTGAGAACAAAATCCTGGCCCGTGCTTGGTCAAAGCAAACCCATTTCACTGTCAGGACCCCCGGTCAC
ACAGGAACCACCCGCCAGGGGAGCCTGTGACTGTCAGTTCCTGTCCCAGGCTTTGCCCGGCCGCCCCAGGAACCCAACCCTCTGGGCTGA
CCTTTCTCCTGCTTCTCTCCAGGCTCTGCAGGGGACAGGGCAGGTGCTGCAGGAGCCCCTTTGCTGGCTTTATCTGCTCCCTTGTTCTGG
ACACAGAGCCCTGGGAAAAAGAGGGGGTGGAAGACAGACAAGGAAGGTGGAATGTTCTGTTTTGGCCACCAGGAAATGGGGTGGGGTGGG
CATACACAGAGAGGACCCCTCTCTTAATACAGCTGCTTTTCTCGGTGCCAACCTCCCTCCCCCAAGCTCAGATCCTCCTCTTATGCCCTT
GATTGTGCCAGCCCATGCCACCCCCATCCTGGGCACAGTTACACCCTCCCATGCAGTGGGAGAAACACAGACCCTCGTACCCAAAGGCCC
CTGCCCCACTTCTCCCCCACAAAGCGGGGTCTCAAGCCACACTGCCCTGTTTGCTGCCATGAGGCCCCCCCCCCCAGCAATATCCCAGGG
GCGGGCCCAATGCCCACTGTACATGAGGCTGCATGATGGGTCTGGGGCCTTGCTGATTCCCCAGACCCCTAATTAAATGTTTCTTGTCCC

>52722_52722_1_MED24-STAC2_MED24_chr17_38209550_ENST00000394126_STAC2_chr17_37369385_ENST00000333461_length(amino acids)=261AA_BP=
MHPSLGNRARLRLKKKKRKKEKETQELPGHTETQLRTKSWPVLGQSKPISLSGPPVTQEPPARGACDCQFLSQALPGRPRNPTLWADLSP
ASLQALQGTGQVLQEPLCWLYLLPCSGHRALGKRGGGRQTRKVECSVLATRKWGGVGIHREDPSLNTAAFLGANLPPPSSDPPLMPLIVP

--------------------------------------------------------------
>52722_52722_2_MED24-STAC2_MED24_chr17_38209550_ENST00000501516_STAC2_chr17_37369385_ENST00000333461_length(transcript)=2222nt_BP=223nt
GAGTGAAATAATGAAGGTGGTCAACCTGAAGCAAGCCATTTTGCAAGCCTGGAAGGAGCGCTGGAGTGACTACCAATGGGCAATCAACAT
GAAGAAATTCTTTCCTAAAGGAGCCACCTGGGATATTCTCAACCTGGCAGATGCGTTACTAGAGCAGGCCATGATTGGACCATCCCCCAA
TCCTCTCATCTTGTCCTACCTGAAGTATGCCATTAGTTCCCAGGGCAAGATCGGCGACCGGGTTGGCTTCTTCCCAGCTAATTTTGTGCA
ACGGGTGAGGCCAGGCGAGAATGTTTGGCGCTGCTGCCAACCCTTCTCCGGGAACAAGGAACAGGGTTACATGAGCCTCAAGGAGAACCA
GATCTGCGTGGGCGTGGGCAGAAGCAAGGATGCTGACGGCTTCATCCGCGTCAGCAGTGGCAAGAAGCGGGGCCTGGTGCCAGTCGACGC
CCTGACTGAGATCTGAGAGGAGCCAAGGGAACCCAGATGACACCCTTGCCCATGCCTGGACCTTGCTTCTGGCCAGGGAGGGGATCAGGC
CCCCTTGTCCACTCCATACCCTTCCTCCCTCTGTCCCTCTCCTAGGTGCCACTTACCGTGGCTTAGGAGCCTTTTGTACTGGGGAAGATT
TTATTTCTTGGGTGGGGTGCCCTGAGTGGGTTGATCCTCTGGGACTTGGCGGGGATGGGGTGGGGTGGGAGGGAATGAGGAAGCTACAGG
TAGGTCCACCCAACGCCCAGGCACCCCAGTCTACTTGCTGGGCTGAGTCCAGCCCTGGGGAAGATTCCTGGGGAATTTATTTGCTGCTTC
TCCCAGCCTTCCCCTGCCCACACCACCTGCGCATGCCTGGCACACCCCTCTCCCCACAGAGCCTCTGCTTGGGTCTATGTGTGTGTGACC
GTGCATCTGCTCCTTTGCAAGTGGGGTCTTGGGAGCAGGCCTTTTTGTGTCCTCGGCCCTCCACCCTTGGTGGGGAGGGGACCCAGGACC
ATAGGAAGGTCCTGAGTCCACCTCCTGGTCTCCACCTCTGTCATTCCGTCAATTCTCAGGAAAGTTTTGCAGGAATCTCTCCCGTTACTT
GAAACCTGGGCGGACAGATGAGGGGAAGGCTGAGGTCCCTGGAAGGTGTAACAAATCAGAGACTATCTGTTCAAGTAGAAAACCCAAGAG
CTGGCCAGGTGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGCAGATCACCTGAGGTCAGGAGTTCAAGACCAG
CCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAGTACGAAACTTAGCCAGGCATGATGGGGGTCTGCCTGTAATGCCAGCTACTCCA
GAGGCTGAGGCAAGAGAATCACTTGAACCCGGGAGGCGGAGGTTTCAGTGAGCCGAGATTGCACCATTGCACCCCAGCCTGGGCAACAGA
GCGAGACTCCGTCTCAAAAAAAAAAAAAGAAAGAAAGAAAAGGAAACCCAAGAGCTGCCTGGACACACGGAAACCCAACTGAGAACAAAA
TCCTGGCCCGTGCTTGGTCAAAGCAAACCCATTTCACTGTCAGGACCCCCGGTCACACAGGAACCACCCGCCAGGGGAGCCTGTGACTGT
CAGTTCCTGTCCCAGGCTTTGCCCGGCCGCCCCAGGAACCCAACCCTCTGGGCTGACCTTTCTCCTGCTTCTCTCCAGGCTCTGCAGGGG
ACAGGGCAGGTGCTGCAGGAGCCCCTTTGCTGGCTTTATCTGCTCCCTTGTTCTGGACACAGAGCCCTGGGAAAAAGAGGGGGTGGAAGA
CAGACAAGGAAGGTGGAATGTTCTGTTTTGGCCACCAGGAAATGGGGTGGGGTGGGCATACACAGAGAGGACCCCTCTCTTAATACAGCT
GCTTTTCTCGGTGCCAACCTCCCTCCCCCAAGCTCAGATCCTCCTCTTATGCCCTTGATTGTGCCAGCCCATGCCACCCCCATCCTGGGC
ACAGTTACACCCTCCCATGCAGTGGGAGAAACACAGACCCTCGTACCCAAAGGCCCCTGCCCCACTTCTCCCCCACAAAGCGGGGTCTCA
AGCCACACTGCCCTGTTTGCTGCCATGAGGCCCCCCCCCCCAGCAATATCCCAGGGGCGGGCCCAATGCCCACTGTACATGAGGCTGCAT

>52722_52722_2_MED24-STAC2_MED24_chr17_38209550_ENST00000501516_STAC2_chr17_37369385_ENST00000333461_length(amino acids)=261AA_BP=
MHPSLGNRARLRLKKKKRKKEKETQELPGHTETQLRTKSWPVLGQSKPISLSGPPVTQEPPARGACDCQFLSQALPGRPRNPTLWADLSP
ASLQALQGTGQVLQEPLCWLYLLPCSGHRALGKRGGGRQTRKVECSVLATRKWGGVGIHREDPSLNTAAFLGANLPPPSSDPPLMPLIVP

--------------------------------------------------------------
>52722_52722_3_MED24-STAC2_MED24_chr17_38209551_ENST00000394126_STAC2_chr17_37369385_ENST00000333461_length(transcript)=2706nt_BP=707nt
GGTGCGATCTCGGCTCACCCCAACAACCTCCGCCTCCCGGGTTCAAGCGATTCTACTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGC
ATGCACCACCAAGCCCGGCTAATTTTGTATTTTTAGTGGAGACGAGGTTTCTCCATGTTGGTCAGGCTAGTCTCGAACTCCTGACCTCCG
GTGATTCGCCCGCCTCTGCCTCCCGAAGTGCTGGGATTACAGGTGCGAGCCACTGCGCTCGGCCGATACTTTCTTAGTGCCCCAGTTTAA
GGAAGGGCGGTTCAGGAGGAGAGAGTCTGACAGGATCTTACTTTATCCCTTTAGCTCTTTTTCTTTCAAATTCCTCTGTCTCGCTTAAAT
CTTCCCGCATCTTCTCCTTTCTATTTAATTCTGCCTTCCCCGGTTCTCCTTAGAACCTCATGTCCTTTTCTTTAGCTCCATTTCTTTCAC
CTCAAAGCTGGCCGCCACCGCTGCCACCTGCTCAGAGTGAAATAATGAAGGTGGTCAACCTGAAGCAAGCCATTTTGCAAGCCTGGAAGG
AGCGCTGGAGTGACTACCAATGGGCAATCAACATGAAGAAATTCTTTCCTAAAGGAGCCACCTGGGATATTCTCAACCTGGCAGATGCGT
TACTAGAGCAGGCCATGATTGGACCATCCCCCAATCCTCTCATCTTGTCCTACCTGAAGTATGCCATTAGTTCCCAGGGCAAGATCGGCG
ACCGGGTTGGCTTCTTCCCAGCTAATTTTGTGCAACGGGTGAGGCCAGGCGAGAATGTTTGGCGCTGCTGCCAACCCTTCTCCGGGAACA
AGGAACAGGGTTACATGAGCCTCAAGGAGAACCAGATCTGCGTGGGCGTGGGCAGAAGCAAGGATGCTGACGGCTTCATCCGCGTCAGCA
GTGGCAAGAAGCGGGGCCTGGTGCCAGTCGACGCCCTGACTGAGATCTGAGAGGAGCCAAGGGAACCCAGATGACACCCTTGCCCATGCC
TGGACCTTGCTTCTGGCCAGGGAGGGGATCAGGCCCCCTTGTCCACTCCATACCCTTCCTCCCTCTGTCCCTCTCCTAGGTGCCACTTAC
CGTGGCTTAGGAGCCTTTTGTACTGGGGAAGATTTTATTTCTTGGGTGGGGTGCCCTGAGTGGGTTGATCCTCTGGGACTTGGCGGGGAT
GGGGTGGGGTGGGAGGGAATGAGGAAGCTACAGGTAGGTCCACCCAACGCCCAGGCACCCCAGTCTACTTGCTGGGCTGAGTCCAGCCCT
GGGGAAGATTCCTGGGGAATTTATTTGCTGCTTCTCCCAGCCTTCCCCTGCCCACACCACCTGCGCATGCCTGGCACACCCCTCTCCCCA
CAGAGCCTCTGCTTGGGTCTATGTGTGTGTGACCGTGCATCTGCTCCTTTGCAAGTGGGGTCTTGGGAGCAGGCCTTTTTGTGTCCTCGG
CCCTCCACCCTTGGTGGGGAGGGGACCCAGGACCATAGGAAGGTCCTGAGTCCACCTCCTGGTCTCCACCTCTGTCATTCCGTCAATTCT
CAGGAAAGTTTTGCAGGAATCTCTCCCGTTACTTGAAACCTGGGCGGACAGATGAGGGGAAGGCTGAGGTCCCTGGAAGGTGTAACAAAT
CAGAGACTATCTGTTCAAGTAGAAAACCCAAGAGCTGGCCAGGTGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTG
GGCAGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAGTACGAAACTTAGCCAGGCA
TGATGGGGGTCTGCCTGTAATGCCAGCTACTCCAGAGGCTGAGGCAAGAGAATCACTTGAACCCGGGAGGCGGAGGTTTCAGTGAGCCGA
GATTGCACCATTGCACCCCAGCCTGGGCAACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAGAAAGAAAGAAAAGGAAACCCAAGAGCT
GCCTGGACACACGGAAACCCAACTGAGAACAAAATCCTGGCCCGTGCTTGGTCAAAGCAAACCCATTTCACTGTCAGGACCCCCGGTCAC
ACAGGAACCACCCGCCAGGGGAGCCTGTGACTGTCAGTTCCTGTCCCAGGCTTTGCCCGGCCGCCCCAGGAACCCAACCCTCTGGGCTGA
CCTTTCTCCTGCTTCTCTCCAGGCTCTGCAGGGGACAGGGCAGGTGCTGCAGGAGCCCCTTTGCTGGCTTTATCTGCTCCCTTGTTCTGG
ACACAGAGCCCTGGGAAAAAGAGGGGGTGGAAGACAGACAAGGAAGGTGGAATGTTCTGTTTTGGCCACCAGGAAATGGGGTGGGGTGGG
CATACACAGAGAGGACCCCTCTCTTAATACAGCTGCTTTTCTCGGTGCCAACCTCCCTCCCCCAAGCTCAGATCCTCCTCTTATGCCCTT
GATTGTGCCAGCCCATGCCACCCCCATCCTGGGCACAGTTACACCCTCCCATGCAGTGGGAGAAACACAGACCCTCGTACCCAAAGGCCC
CTGCCCCACTTCTCCCCCACAAAGCGGGGTCTCAAGCCACACTGCCCTGTTTGCTGCCATGAGGCCCCCCCCCCCAGCAATATCCCAGGG
GCGGGCCCAATGCCCACTGTACATGAGGCTGCATGATGGGTCTGGGGCCTTGCTGATTCCCCAGACCCCTAATTAAATGTTTCTTGTCCC

>52722_52722_3_MED24-STAC2_MED24_chr17_38209551_ENST00000394126_STAC2_chr17_37369385_ENST00000333461_length(amino acids)=261AA_BP=
MHPSLGNRARLRLKKKKRKKEKETQELPGHTETQLRTKSWPVLGQSKPISLSGPPVTQEPPARGACDCQFLSQALPGRPRNPTLWADLSP
ASLQALQGTGQVLQEPLCWLYLLPCSGHRALGKRGGGRQTRKVECSVLATRKWGGVGIHREDPSLNTAAFLGANLPPPSSDPPLMPLIVP

--------------------------------------------------------------
>52722_52722_4_MED24-STAC2_MED24_chr17_38209551_ENST00000501516_STAC2_chr17_37369385_ENST00000333461_length(transcript)=2222nt_BP=223nt
GAGTGAAATAATGAAGGTGGTCAACCTGAAGCAAGCCATTTTGCAAGCCTGGAAGGAGCGCTGGAGTGACTACCAATGGGCAATCAACAT
GAAGAAATTCTTTCCTAAAGGAGCCACCTGGGATATTCTCAACCTGGCAGATGCGTTACTAGAGCAGGCCATGATTGGACCATCCCCCAA
TCCTCTCATCTTGTCCTACCTGAAGTATGCCATTAGTTCCCAGGGCAAGATCGGCGACCGGGTTGGCTTCTTCCCAGCTAATTTTGTGCA
ACGGGTGAGGCCAGGCGAGAATGTTTGGCGCTGCTGCCAACCCTTCTCCGGGAACAAGGAACAGGGTTACATGAGCCTCAAGGAGAACCA
GATCTGCGTGGGCGTGGGCAGAAGCAAGGATGCTGACGGCTTCATCCGCGTCAGCAGTGGCAAGAAGCGGGGCCTGGTGCCAGTCGACGC
CCTGACTGAGATCTGAGAGGAGCCAAGGGAACCCAGATGACACCCTTGCCCATGCCTGGACCTTGCTTCTGGCCAGGGAGGGGATCAGGC
CCCCTTGTCCACTCCATACCCTTCCTCCCTCTGTCCCTCTCCTAGGTGCCACTTACCGTGGCTTAGGAGCCTTTTGTACTGGGGAAGATT
TTATTTCTTGGGTGGGGTGCCCTGAGTGGGTTGATCCTCTGGGACTTGGCGGGGATGGGGTGGGGTGGGAGGGAATGAGGAAGCTACAGG
TAGGTCCACCCAACGCCCAGGCACCCCAGTCTACTTGCTGGGCTGAGTCCAGCCCTGGGGAAGATTCCTGGGGAATTTATTTGCTGCTTC
TCCCAGCCTTCCCCTGCCCACACCACCTGCGCATGCCTGGCACACCCCTCTCCCCACAGAGCCTCTGCTTGGGTCTATGTGTGTGTGACC
GTGCATCTGCTCCTTTGCAAGTGGGGTCTTGGGAGCAGGCCTTTTTGTGTCCTCGGCCCTCCACCCTTGGTGGGGAGGGGACCCAGGACC
ATAGGAAGGTCCTGAGTCCACCTCCTGGTCTCCACCTCTGTCATTCCGTCAATTCTCAGGAAAGTTTTGCAGGAATCTCTCCCGTTACTT
GAAACCTGGGCGGACAGATGAGGGGAAGGCTGAGGTCCCTGGAAGGTGTAACAAATCAGAGACTATCTGTTCAAGTAGAAAACCCAAGAG
CTGGCCAGGTGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGCAGATCACCTGAGGTCAGGAGTTCAAGACCAG
CCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAGTACGAAACTTAGCCAGGCATGATGGGGGTCTGCCTGTAATGCCAGCTACTCCA
GAGGCTGAGGCAAGAGAATCACTTGAACCCGGGAGGCGGAGGTTTCAGTGAGCCGAGATTGCACCATTGCACCCCAGCCTGGGCAACAGA
GCGAGACTCCGTCTCAAAAAAAAAAAAAGAAAGAAAGAAAAGGAAACCCAAGAGCTGCCTGGACACACGGAAACCCAACTGAGAACAAAA
TCCTGGCCCGTGCTTGGTCAAAGCAAACCCATTTCACTGTCAGGACCCCCGGTCACACAGGAACCACCCGCCAGGGGAGCCTGTGACTGT
CAGTTCCTGTCCCAGGCTTTGCCCGGCCGCCCCAGGAACCCAACCCTCTGGGCTGACCTTTCTCCTGCTTCTCTCCAGGCTCTGCAGGGG
ACAGGGCAGGTGCTGCAGGAGCCCCTTTGCTGGCTTTATCTGCTCCCTTGTTCTGGACACAGAGCCCTGGGAAAAAGAGGGGGTGGAAGA
CAGACAAGGAAGGTGGAATGTTCTGTTTTGGCCACCAGGAAATGGGGTGGGGTGGGCATACACAGAGAGGACCCCTCTCTTAATACAGCT
GCTTTTCTCGGTGCCAACCTCCCTCCCCCAAGCTCAGATCCTCCTCTTATGCCCTTGATTGTGCCAGCCCATGCCACCCCCATCCTGGGC
ACAGTTACACCCTCCCATGCAGTGGGAGAAACACAGACCCTCGTACCCAAAGGCCCCTGCCCCACTTCTCCCCCACAAAGCGGGGTCTCA
AGCCACACTGCCCTGTTTGCTGCCATGAGGCCCCCCCCCCCAGCAATATCCCAGGGGCGGGCCCAATGCCCACTGTACATGAGGCTGCAT

>52722_52722_4_MED24-STAC2_MED24_chr17_38209551_ENST00000501516_STAC2_chr17_37369385_ENST00000333461_length(amino acids)=261AA_BP=
MHPSLGNRARLRLKKKKRKKEKETQELPGHTETQLRTKSWPVLGQSKPISLSGPPVTQEPPARGACDCQFLSQALPGRPRNPTLWADLSP
ASLQALQGTGQVLQEPLCWLYLLPCSGHRALGKRGGGRQTRKVECSVLATRKWGGVGIHREDPSLNTAAFLGANLPPPSSDPPLMPLIVP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MED24-STAC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MED24-STAC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MED24-STAC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource