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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MED25-CCDC155 (FusionGDB2 ID:52730)

Fusion Gene Summary for MED25-CCDC155

Fusion gene summary

Fusion gene information	Fusion gene name: MED25-CCDC155
	Fusion gene ID: 52730
		Hgene	Tgene
	Gene symbol	MED25	CCDC155
	Gene ID	81857	147872
	Gene name	mediator complex subunit 25	KASH domain containing 5
	Synonyms	ACID1\|ARC92\|BVSYS\|CMT2B2\|P78\|PTOV2\|TCBAP0758	CCDC155
	Cytomap	19q13.33	19q13.33
	Type of gene	protein-coding	protein-coding
	Description	mediator of RNA polymerase II transcription subunit 25ARC/mediator transcriptional coactivator subunitactivator interaction domain-containing protein 1activator-recruited cofactor 92 kDa componentmediator of RNA polymerase II transcription, subunit 25	protein KASH5KASH domain-containing protein 5coiled-coil domain containing 155
	Modification date	20200328	20200313
	UniProtAcc	Q71SY5	.
	Ensembl transtripts involved in fusion gene	ENST00000312865, ENST00000538643,	ENST00000593725, ENST00000447857,
Fusion gene scores	* DoF score	10 X 6 X 6=360	5 X 5 X 5=125
	# samples	13	7
	** MAII score	log2(13/360*10)=-1.46948528330122 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/125*10)=-0.836501267717121 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MED25 [Title/Abstract] AND CCDC155 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MED25(50335672)-CCDC155(49910143), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MED25	GO:0045944	positive regulation of transcription by RNA polymerase II	17641689

Fusion gene breakpoints across MED25 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CCDC155 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCEC	TCGA-B5-A5OD-01A	MED25	chr19	50335672	-	CCDC155	chr19	49910143	+
ChimerDB4	UCEC	TCGA-B5-A5OD-01A	MED25	chr19	50335672	+	CCDC155	chr19	49910143	+
ChimerDB4	UCEC	TCGA-B5-A5OD	MED25	chr19	50335672	+	CCDC155	chr19	49910142	+

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Fusion Gene ORF analysis for MED25-CCDC155

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000312865	ENST00000593725	MED25	chr19	50335672	+	CCDC155	chr19	49910143	+
5CDS-intron	ENST00000312865	ENST00000593725	MED25	chr19	50335672	+	CCDC155	chr19	49910142	+
5CDS-intron	ENST00000538643	ENST00000593725	MED25	chr19	50335672	+	CCDC155	chr19	49910143	+
5CDS-intron	ENST00000538643	ENST00000593725	MED25	chr19	50335672	+	CCDC155	chr19	49910142	+
In-frame	ENST00000312865	ENST00000447857	MED25	chr19	50335672	+	CCDC155	chr19	49910143	+
In-frame	ENST00000312865	ENST00000447857	MED25	chr19	50335672	+	CCDC155	chr19	49910142	+
In-frame	ENST00000538643	ENST00000447857	MED25	chr19	50335672	+	CCDC155	chr19	49910143	+
In-frame	ENST00000538643	ENST00000447857	MED25	chr19	50335672	+	CCDC155	chr19	49910142	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000312865

MED25

chr19

50335672

ENST00000447857

CCDC155

chr19

49910143

2910

1535

2425

790

ENST00000538643

MED25

chr19

50335672

ENST00000447857

CCDC155

chr19

49910143

2218

843

1733

577

ENST00000312865

MED25

chr19

50335672

ENST00000447857

CCDC155

chr19

49910142

2910

1535

2425

790

ENST00000538643

MED25

chr19

50335672

ENST00000447857

CCDC155

chr19

49910142

2218

843

1733

577

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000312865	ENST00000447857	MED25	chr19	50335672	+	CCDC155	chr19	49910143	+	0.01397591	0.9860241
ENST00000538643	ENST00000447857	MED25	chr19	50335672	+	CCDC155	chr19	49910143	+	0.019340564	0.9806594
ENST00000312865	ENST00000447857	MED25	chr19	50335672	+	CCDC155	chr19	49910142	+	0.01397591	0.9860241
ENST00000538643	ENST00000447857	MED25	chr19	50335672	+	CCDC155	chr19	49910142	+	0.019340564	0.9806594

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Fusion Genomic Features for MED25-CCDC155

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MED25-CCDC155

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:50335672/chr19:49910143)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MED25 Q71SY5	.
FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription. {ECO:0000269\|PubMed:14657022, ECO:0000269\|PubMed:14983011, ECO:0000269\|PubMed:17641689}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MED25

chr19:50335672

chr19:49910142

ENST00000312865

200_381

494

748.0

Compositional bias

Note=Pro-rich

Hgene

MED25

chr19:50335672

chr19:49910143

ENST00000312865

200_381

494

748.0

Compositional bias

Note=Pro-rich

Tgene

CCDC155

chr19:50335672

chr19:49910142

ENST00000447857

448_451

266

563.0

Compositional bias

Note=Poly-Glu

Tgene

CCDC155

chr19:50335672

chr19:49910142

ENST00000447857

528_536

266

563.0

Compositional bias

Note=Poly-Leu

Tgene

CCDC155

chr19:50335672

chr19:49910143

ENST00000447857

448_451

266

563.0

Compositional bias

Note=Poly-Glu

Tgene

CCDC155

chr19:50335672

chr19:49910143

ENST00000447857

528_536

266

563.0

Compositional bias

Note=Poly-Leu

Tgene

CCDC155

chr19:50335672

chr19:49910142

ENST00000447857

543_562

266

563.0

Topological domain

Perinuclear space

Tgene

CCDC155

chr19:50335672

chr19:49910143

ENST00000447857

543_562

266

563.0

Topological domain

Perinuclear space

Tgene

CCDC155

chr19:50335672

chr19:49910142

ENST00000447857

522_542

266

563.0

Transmembrane

Helical%3B Anchor for type IV membrane protein

Tgene

CCDC155

chr19:50335672

chr19:49910143

ENST00000447857

522_542

266

563.0

Transmembrane

Helical%3B Anchor for type IV membrane protein

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MED25

chr19:50335672

chr19:49910142

ENST00000312865

565_735

494

748.0

Compositional bias

Note=Pro-rich

Hgene

MED25

chr19:50335672

chr19:49910142

ENST00000538643

200_381

281

535.0

Compositional bias

Note=Pro-rich

Hgene

MED25

chr19:50335672

chr19:49910142

ENST00000538643

565_735

281

535.0

Compositional bias

Note=Pro-rich

Hgene

MED25

chr19:50335672

chr19:49910143

ENST00000312865

565_735

494

748.0

Compositional bias

Note=Pro-rich

Hgene

MED25

chr19:50335672

chr19:49910143

ENST00000538643

200_381

281

535.0

Compositional bias

Note=Pro-rich

Hgene

MED25

chr19:50335672

chr19:49910143

ENST00000538643

565_735

281

535.0

Compositional bias

Note=Pro-rich

Hgene

MED25

chr19:50335672

chr19:49910142

ENST00000312865

646_650

494

748.0

Motif

Note=LXXLL motif

Hgene

MED25

chr19:50335672

chr19:49910142

ENST00000538643

646_650

281

535.0

Motif

Note=LXXLL motif

Hgene

MED25

chr19:50335672

chr19:49910143

ENST00000312865

646_650

494

748.0

Motif

Note=LXXLL motif

Hgene

MED25

chr19:50335672

chr19:49910143

ENST00000538643

646_650

281

535.0

Motif

Note=LXXLL motif

Tgene

CCDC155

chr19:50335672

chr19:49910142

ENST00000447857

164_349

266

563.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CCDC155

chr19:50335672

chr19:49910143

ENST00000447857

164_349

266

563.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CCDC155

chr19:50335672

chr19:49910142

ENST00000447857

1_521

266

563.0

Topological domain

Cytoplasmic

Tgene

CCDC155

chr19:50335672

chr19:49910143

ENST00000447857

1_521

266

563.0

Topological domain

Cytoplasmic

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Fusion Gene Sequence for MED25-CCDC155

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>52730_52730_1_MED25-CCDC155_MED25_chr19_50335672_ENST00000312865_CCDC155_chr19_49910142_ENST00000447857_length(transcript)=2910nt_BP=1535nt
ATTCCGCGGCGTCGGCTGCGGCTGCAGTGGTGGTGGCGGGTACCGCACGGGGTATGGTCCCCGGGTCCGAGGGCCCGGCCCGCGCCGGGA
GCGTGGTGGCCGACGTGGTGTTTGTGATTGAGGGTACGGCCAACCTGGGACCCTACTTCGAGGGGCTCCGCAAGCACTACCTGCTCCCGG
CCATCGAGTATTTTAATGGTGGTCCTCCTGCTGAGACGGACTTCGGGGGAGACTATGGGGGGACCCAGTACAGCCTCGTGGTGTTCAACA
CAGTGGACTGCGCTCCCGAGTCCTACGTACAATGTCACGCTCCCACCAGCAGCGCCTATGAGTTTGTCACCTGGCTCGATGGCATTAAGT
TCATGGGCGGGGGTGGTGAGAGCTGCAGCCTCATCGCGGAAGGACTCAGCACAGCCTTGCAGCTGTTTGATGACTTCAAGAAGATGCGCG
AGCAGATTGGCCAGACGCACCGGGTCTGCCTCCTCATCTGCAACTCACCCCCATACTTGTTGCCTGCTGTTGAGAGCACCACGTACTCTG
GATGCACAACTGAGAATCTTGTGCAGCAGATTGGGGAGCGGGGGATCCACTTCTCCATTGTGTCTCCCCGGAAGCTGCCTGCGCTTCGGC
TTCTGTTTGAGAAGGCAGCCCCCCCGGCCTTGCTGGAGCCGCTGCAGCCTCCGACAGATGTGAGCCAGGACCCGAGGCACATGGTGCTGG
TTCGGGGACTCGTGCTGCCTGTTGGGGGTGGCTCAGCCCCAGGCCCCCTCCAGTCAAAGCAGCCAGTCCCCCTGCCTCCCGCCGCACCCT
CAGGTGCCACTCTCTCAGCAGCCCCCCAGCAGCCTCTGCCCCCCGTCCCCCCGCAGTACCAGGTTCCCGGGAACCTGAGTGCAGCTCAGG
TGGCCGCGCAGAATGCAGTGGAGGCTGCCAAGAACCAGAAGGCTGGGCTGGGCCCTCGCTTCTCGCCCATCACCCCTCTCCAACAAGCTG
CTCCCGGAGTGGGTCCCCCCTTCAGCCAGGCCCCAGCTCCCCAACTACCCCCAGGACCCCCTGGCGCCCCCAAGCCACCACCTGCTTCCC
AGCCCAGTCTGGTCTCCACTGTGGCCCCTGGCTCCGGCCTGGCTCCCACGGCACAGCCCGGGGCACCGTCCATGGCAGGCACTGTGGCCC
CAGGAGGGGTGAGCGGCCCTTCCCCAGCCCAGCTGGGAGCCCCAGCCCTCGGTGGGCAGCAGTCAGTCTCCAATAAGCTTCTGGCCTGGA
GCGGGGTCCTGGAGTGGCAAGAGAAACCCAAACCTGCCTCAGTGGATGCCAACACCAAGCTGACGCGGTCACTGCCCTGCCAGGTCTACG
TGAATCATGGCGAGAACCTGAAGACGGAGCAGTGGCCCCAGAAGCTGATCATGCAGCTCATCCCCCAGCAGCTGCTGACCACCCTGGGCC
CTTTGTTCCGGAACTCAAGGATGGTCCAGTTCCATTTCACCAACAAGGACCTGGAGTCTCTCAAAGGCCTCTACCGCATCATGGGCAACG
GCTTCAACGGGAAGCTGCTTGCCGAGCGGGATGGAGTGAAAAAGAGAAGTCAGGAGCTGGCCATGGAGAAGGACACTTTGAAGCGGCAGC
TCTTTGAGTGTGAACACCTCATTTGCCAAAGAGACACCATCCTCTCTGAGCGCACTCGCGATGTGGAGAGCCTGGCCCAGACCCTGGAAG
AATACAGAGTGACGACGCAGGAACTGAGGCTGGAGATTTCACGCCTGGAGGAGCAGCTGAGTCAGACCTATGAGGGGCCCGATGAGCTAC
CTGAAGGGGCCCAGCTGAGAAGAGTGGGCTGGACCGAGCTGCTACCCCCATCGCTGGGCTTGGAGATCGAGGCCATTCGACAGAAACAGG
AAGTGGCAACTGCTGATCTCTCCAACCCTCTGTGTGGGGTGTGGCAGTGGGAGGAAGTCATCCATGAGACCAGTGAGGAAACTGAGTTTC
CATCTGAAGCCCCAGCTGGGGGACAGAGAAACTTCCAGGGAGAGCCAGCGCACCCTGAAGAAGGAAGGAAGGAGCCATCCATGTGGTTGA
CCAGAAGAGAGGAAGAGGAGGATGCAGAGAGCCAGGTCACGGCTGATCTCCCTGTCCCTCTAGGAGCCCCTCGCCCTGGAGACATCCCAG
AAAACCCTCCAGAGAGACCTGCGCGGCGGGAACTCCAGCAAGCCCTGGTGCCTGTGATGAAAAAGCTGGTCCCAGTCAGGAGGAGGGCCT
GGGGCCAGCTCTGCCTGCCCCCACAGCGGCTCAGAGTCACTCGACATCCACTGATCCCAGCTCCTGTCCTGGGCCTGCTGCTGCTGCTGC
TGCTCTCTGTCCTGCTGCTTGGCCCGTCCCCACCTCCCACCTGGCCCCACCTCCAGCTCTGCTACCTCCAGCCCCCTCCAGTGTGAGAGG
CTCTACTTGCCCCTCAGAGCAGTGTCTAGCTCAATAAATCCCCTGGCCCTCTCTCCACTGGGATCCCCATTGTTAGTCCACTGTTGCGCA
GGCTTACCCTAGATAGAGTACAGGGGATCCACATCCCTGTATTTTTATGTGAAGTCTCCTAGTTTTTTAATGCTGACATTTCTTAACAAT
AGCAAAACTCCCCCAGTAATGGATTAAGCACTAAGGATTATTCCCTCACAAAACAAGCCTGGCGAGGGCAGCTGTGGGCACACAGCTAAG
TCTCGGTTGCCTTGGGGTCAGGGCCTCAGTGATTCTCCTGTCCCCTCCCTCATGCTCAGGAGTTGGCAGTTGTAGCTTCCTACATCACAT
CTGCGGGAAACGGAAATTTCTTCCTTCCTTTTTATAAAGAGAGGCAGTAGCCTCAGTGTGCAGTGGGTAGATTCAAATCATATTCATAAT

>52730_52730_1_MED25-CCDC155_MED25_chr19_50335672_ENST00000312865_CCDC155_chr19_49910142_ENST00000447857_length(amino acids)=790AA_BP=494
MVPGSEGPARAGSVVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSS
AYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTENLVQQIGERGIHF
SIVSPRKLPALRLLFEKAAPPALLEPLQPPTDVSQDPRHMVLVRGLVLPVGGGSAPGPLQSKQPVPLPPAAPSGATLSAAPQQPLPPVPP
QYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTA
QPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIM
QLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFNGKLLAERDGVKKRSQELAMEKDTLKRQLFECEHLICQRDTILSER
TRDVESLAQTLEEYRVTTQELRLEISRLEEQLSQTYEGPDELPEGAQLRRVGWTELLPPSLGLEIEAIRQKQEVATADLSNPLCGVWQWE
EVIHETSEETEFPSEAPAGGQRNFQGEPAHPEEGRKEPSMWLTRREEEEDAESQVTADLPVPLGAPRPGDIPENPPERPARRELQQALVP

--------------------------------------------------------------
>52730_52730_2_MED25-CCDC155_MED25_chr19_50335672_ENST00000312865_CCDC155_chr19_49910143_ENST00000447857_length(transcript)=2910nt_BP=1535nt
ATTCCGCGGCGTCGGCTGCGGCTGCAGTGGTGGTGGCGGGTACCGCACGGGGTATGGTCCCCGGGTCCGAGGGCCCGGCCCGCGCCGGGA
GCGTGGTGGCCGACGTGGTGTTTGTGATTGAGGGTACGGCCAACCTGGGACCCTACTTCGAGGGGCTCCGCAAGCACTACCTGCTCCCGG
CCATCGAGTATTTTAATGGTGGTCCTCCTGCTGAGACGGACTTCGGGGGAGACTATGGGGGGACCCAGTACAGCCTCGTGGTGTTCAACA
CAGTGGACTGCGCTCCCGAGTCCTACGTACAATGTCACGCTCCCACCAGCAGCGCCTATGAGTTTGTCACCTGGCTCGATGGCATTAAGT
TCATGGGCGGGGGTGGTGAGAGCTGCAGCCTCATCGCGGAAGGACTCAGCACAGCCTTGCAGCTGTTTGATGACTTCAAGAAGATGCGCG
AGCAGATTGGCCAGACGCACCGGGTCTGCCTCCTCATCTGCAACTCACCCCCATACTTGTTGCCTGCTGTTGAGAGCACCACGTACTCTG
GATGCACAACTGAGAATCTTGTGCAGCAGATTGGGGAGCGGGGGATCCACTTCTCCATTGTGTCTCCCCGGAAGCTGCCTGCGCTTCGGC
TTCTGTTTGAGAAGGCAGCCCCCCCGGCCTTGCTGGAGCCGCTGCAGCCTCCGACAGATGTGAGCCAGGACCCGAGGCACATGGTGCTGG
TTCGGGGACTCGTGCTGCCTGTTGGGGGTGGCTCAGCCCCAGGCCCCCTCCAGTCAAAGCAGCCAGTCCCCCTGCCTCCCGCCGCACCCT
CAGGTGCCACTCTCTCAGCAGCCCCCCAGCAGCCTCTGCCCCCCGTCCCCCCGCAGTACCAGGTTCCCGGGAACCTGAGTGCAGCTCAGG
TGGCCGCGCAGAATGCAGTGGAGGCTGCCAAGAACCAGAAGGCTGGGCTGGGCCCTCGCTTCTCGCCCATCACCCCTCTCCAACAAGCTG
CTCCCGGAGTGGGTCCCCCCTTCAGCCAGGCCCCAGCTCCCCAACTACCCCCAGGACCCCCTGGCGCCCCCAAGCCACCACCTGCTTCCC
AGCCCAGTCTGGTCTCCACTGTGGCCCCTGGCTCCGGCCTGGCTCCCACGGCACAGCCCGGGGCACCGTCCATGGCAGGCACTGTGGCCC
CAGGAGGGGTGAGCGGCCCTTCCCCAGCCCAGCTGGGAGCCCCAGCCCTCGGTGGGCAGCAGTCAGTCTCCAATAAGCTTCTGGCCTGGA
GCGGGGTCCTGGAGTGGCAAGAGAAACCCAAACCTGCCTCAGTGGATGCCAACACCAAGCTGACGCGGTCACTGCCCTGCCAGGTCTACG
TGAATCATGGCGAGAACCTGAAGACGGAGCAGTGGCCCCAGAAGCTGATCATGCAGCTCATCCCCCAGCAGCTGCTGACCACCCTGGGCC
CTTTGTTCCGGAACTCAAGGATGGTCCAGTTCCATTTCACCAACAAGGACCTGGAGTCTCTCAAAGGCCTCTACCGCATCATGGGCAACG
GCTTCAACGGGAAGCTGCTTGCCGAGCGGGATGGAGTGAAAAAGAGAAGTCAGGAGCTGGCCATGGAGAAGGACACTTTGAAGCGGCAGC
TCTTTGAGTGTGAACACCTCATTTGCCAAAGAGACACCATCCTCTCTGAGCGCACTCGCGATGTGGAGAGCCTGGCCCAGACCCTGGAAG
AATACAGAGTGACGACGCAGGAACTGAGGCTGGAGATTTCACGCCTGGAGGAGCAGCTGAGTCAGACCTATGAGGGGCCCGATGAGCTAC
CTGAAGGGGCCCAGCTGAGAAGAGTGGGCTGGACCGAGCTGCTACCCCCATCGCTGGGCTTGGAGATCGAGGCCATTCGACAGAAACAGG
AAGTGGCAACTGCTGATCTCTCCAACCCTCTGTGTGGGGTGTGGCAGTGGGAGGAAGTCATCCATGAGACCAGTGAGGAAACTGAGTTTC
CATCTGAAGCCCCAGCTGGGGGACAGAGAAACTTCCAGGGAGAGCCAGCGCACCCTGAAGAAGGAAGGAAGGAGCCATCCATGTGGTTGA
CCAGAAGAGAGGAAGAGGAGGATGCAGAGAGCCAGGTCACGGCTGATCTCCCTGTCCCTCTAGGAGCCCCTCGCCCTGGAGACATCCCAG
AAAACCCTCCAGAGAGACCTGCGCGGCGGGAACTCCAGCAAGCCCTGGTGCCTGTGATGAAAAAGCTGGTCCCAGTCAGGAGGAGGGCCT
GGGGCCAGCTCTGCCTGCCCCCACAGCGGCTCAGAGTCACTCGACATCCACTGATCCCAGCTCCTGTCCTGGGCCTGCTGCTGCTGCTGC
TGCTCTCTGTCCTGCTGCTTGGCCCGTCCCCACCTCCCACCTGGCCCCACCTCCAGCTCTGCTACCTCCAGCCCCCTCCAGTGTGAGAGG
CTCTACTTGCCCCTCAGAGCAGTGTCTAGCTCAATAAATCCCCTGGCCCTCTCTCCACTGGGATCCCCATTGTTAGTCCACTGTTGCGCA
GGCTTACCCTAGATAGAGTACAGGGGATCCACATCCCTGTATTTTTATGTGAAGTCTCCTAGTTTTTTAATGCTGACATTTCTTAACAAT
AGCAAAACTCCCCCAGTAATGGATTAAGCACTAAGGATTATTCCCTCACAAAACAAGCCTGGCGAGGGCAGCTGTGGGCACACAGCTAAG
TCTCGGTTGCCTTGGGGTCAGGGCCTCAGTGATTCTCCTGTCCCCTCCCTCATGCTCAGGAGTTGGCAGTTGTAGCTTCCTACATCACAT
CTGCGGGAAACGGAAATTTCTTCCTTCCTTTTTATAAAGAGAGGCAGTAGCCTCAGTGTGCAGTGGGTAGATTCAAATCATATTCATAAT

>52730_52730_2_MED25-CCDC155_MED25_chr19_50335672_ENST00000312865_CCDC155_chr19_49910143_ENST00000447857_length(amino acids)=790AA_BP=494
MVPGSEGPARAGSVVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSS
AYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTENLVQQIGERGIHF
SIVSPRKLPALRLLFEKAAPPALLEPLQPPTDVSQDPRHMVLVRGLVLPVGGGSAPGPLQSKQPVPLPPAAPSGATLSAAPQQPLPPVPP
QYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTA
QPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIM
QLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFNGKLLAERDGVKKRSQELAMEKDTLKRQLFECEHLICQRDTILSER
TRDVESLAQTLEEYRVTTQELRLEISRLEEQLSQTYEGPDELPEGAQLRRVGWTELLPPSLGLEIEAIRQKQEVATADLSNPLCGVWQWE
EVIHETSEETEFPSEAPAGGQRNFQGEPAHPEEGRKEPSMWLTRREEEEDAESQVTADLPVPLGAPRPGDIPENPPERPARRELQQALVP

--------------------------------------------------------------
>52730_52730_3_MED25-CCDC155_MED25_chr19_50335672_ENST00000538643_CCDC155_chr19_49910142_ENST00000447857_length(transcript)=2218nt_BP=843nt
ATGGTCCCCGGGTCCGAGGGCCCGGCCCGCGCCGGGAGCGTGGTGGCCGACGTGGTGTTTGTGATTGAGGGTACGGCCAACCTGGGACCC
TACTTCGAGGGGCTCCGCAAGCACTACCTGCTCCCGGCCATCGAGTATTTTAATGGTGGTCCTCCTGCTGAGACGGACTTCGGGGGAGAC
GTTCCCGGGAACCTGAGTGCAGCTCAGGTGGCCGCGCAGAATGCAGTGGAGGCTGCCAAGAACCAGAAGGCTGGGCTGGGCCCTCGCTTC
TCGCCCATCACCCCTCTCCAACAAGCTGCTCCCGGAGTGGGTCCCCCCTTCAGCCAGGCCCCAGCTCCCCAACTACCCCCAGGACCCCCT
GGCGCCCCCAAGCCACCACCTGCTTCCCAGCCCAGTCTGGTCTCCACTGTGGCCCCTGGCTCCGGCCTGGCTCCCACGGCACAGCCCGGG
GCACCGTCCATGGCAGGCACTGTGGCCCCAGGAGGGGTGAGCGGCCCTTCCCCAGCCCAGCTGGGAGCCCCAGCCCTCGGTGGGCAGCAG
TCAGTCTCCAATAAGCTTCTGGCCTGGAGCGGGGTCCTGGAGTGGCAAGAGAAACCCAAACCTGCCTCAGTGGATGCCAACACCAAGCTG
ACGCGGTCACTGCCCTGCCAGGTCTACGTGAATCATGGCGAGAACCTGAAGACGGAGCAGTGGCCCCAGAAGCTGATCATGCAGCTCATC
CCCCAGCAGCTGCTGACCACCCTGGGCCCTTTGTTCCGGAACTCAAGGATGGTCCAGTTCCATTTCACCAACAAGGACCTGGAGTCTCTC
AAAGGCCTCTACCGCATCATGGGCAACGGCTTCAACGGGAAGCTGCTTGCCGAGCGGGATGGAGTGAAAAAGAGAAGTCAGGAGCTGGCC
ATGGAGAAGGACACTTTGAAGCGGCAGCTCTTTGAGTGTGAACACCTCATTTGCCAAAGAGACACCATCCTCTCTGAGCGCACTCGCGAT
GTGGAGAGCCTGGCCCAGACCCTGGAAGAATACAGAGTGACGACGCAGGAACTGAGGCTGGAGATTTCACGCCTGGAGGAGCAGCTGAGT
CAGACCTATGAGGGGCCCGATGAGCTACCTGAAGGGGCCCAGCTGAGAAGAGTGGGCTGGACCGAGCTGCTACCCCCATCGCTGGGCTTG
GAGATCGAGGCCATTCGACAGAAACAGGAAGTGGCAACTGCTGATCTCTCCAACCCTCTGTGTGGGGTGTGGCAGTGGGAGGAAGTCATC
CATGAGACCAGTGAGGAAACTGAGTTTCCATCTGAAGCCCCAGCTGGGGGACAGAGAAACTTCCAGGGAGAGCCAGCGCACCCTGAAGAA
GGAAGGAAGGAGCCATCCATGTGGTTGACCAGAAGAGAGGAAGAGGAGGATGCAGAGAGCCAGGTCACGGCTGATCTCCCTGTCCCTCTA
GGAGCCCCTCGCCCTGGAGACATCCCAGAAAACCCTCCAGAGAGACCTGCGCGGCGGGAACTCCAGCAAGCCCTGGTGCCTGTGATGAAA
AAGCTGGTCCCAGTCAGGAGGAGGGCCTGGGGCCAGCTCTGCCTGCCCCCACAGCGGCTCAGAGTCACTCGACATCCACTGATCCCAGCT
CCTGTCCTGGGCCTGCTGCTGCTGCTGCTGCTCTCTGTCCTGCTGCTTGGCCCGTCCCCACCTCCCACCTGGCCCCACCTCCAGCTCTGC
TACCTCCAGCCCCCTCCAGTGTGAGAGGCTCTACTTGCCCCTCAGAGCAGTGTCTAGCTCAATAAATCCCCTGGCCCTCTCTCCACTGGG
ATCCCCATTGTTAGTCCACTGTTGCGCAGGCTTACCCTAGATAGAGTACAGGGGATCCACATCCCTGTATTTTTATGTGAAGTCTCCTAG
TTTTTTAATGCTGACATTTCTTAACAATAGCAAAACTCCCCCAGTAATGGATTAAGCACTAAGGATTATTCCCTCACAAAACAAGCCTGG
CGAGGGCAGCTGTGGGCACACAGCTAAGTCTCGGTTGCCTTGGGGTCAGGGCCTCAGTGATTCTCCTGTCCCCTCCCTCATGCTCAGGAG
TTGGCAGTTGTAGCTTCCTACATCACATCTGCGGGAAACGGAAATTTCTTCCTTCCTTTTTATAAAGAGAGGCAGTAGCCTCAGTGTGCA

>52730_52730_3_MED25-CCDC155_MED25_chr19_50335672_ENST00000538643_CCDC155_chr19_49910142_ENST00000447857_length(amino acids)=577AA_BP=281
MVPGSEGPARAGSVVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDVPGNLSAAQVAAQNAVEAAKNQKAGLGPRF
SPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQ
SVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESL
KGLYRIMGNGFNGKLLAERDGVKKRSQELAMEKDTLKRQLFECEHLICQRDTILSERTRDVESLAQTLEEYRVTTQELRLEISRLEEQLS
QTYEGPDELPEGAQLRRVGWTELLPPSLGLEIEAIRQKQEVATADLSNPLCGVWQWEEVIHETSEETEFPSEAPAGGQRNFQGEPAHPEE
GRKEPSMWLTRREEEEDAESQVTADLPVPLGAPRPGDIPENPPERPARRELQQALVPVMKKLVPVRRRAWGQLCLPPQRLRVTRHPLIPA

--------------------------------------------------------------
>52730_52730_4_MED25-CCDC155_MED25_chr19_50335672_ENST00000538643_CCDC155_chr19_49910143_ENST00000447857_length(transcript)=2218nt_BP=843nt
ATGGTCCCCGGGTCCGAGGGCCCGGCCCGCGCCGGGAGCGTGGTGGCCGACGTGGTGTTTGTGATTGAGGGTACGGCCAACCTGGGACCC
TACTTCGAGGGGCTCCGCAAGCACTACCTGCTCCCGGCCATCGAGTATTTTAATGGTGGTCCTCCTGCTGAGACGGACTTCGGGGGAGAC
GTTCCCGGGAACCTGAGTGCAGCTCAGGTGGCCGCGCAGAATGCAGTGGAGGCTGCCAAGAACCAGAAGGCTGGGCTGGGCCCTCGCTTC
TCGCCCATCACCCCTCTCCAACAAGCTGCTCCCGGAGTGGGTCCCCCCTTCAGCCAGGCCCCAGCTCCCCAACTACCCCCAGGACCCCCT
GGCGCCCCCAAGCCACCACCTGCTTCCCAGCCCAGTCTGGTCTCCACTGTGGCCCCTGGCTCCGGCCTGGCTCCCACGGCACAGCCCGGG
GCACCGTCCATGGCAGGCACTGTGGCCCCAGGAGGGGTGAGCGGCCCTTCCCCAGCCCAGCTGGGAGCCCCAGCCCTCGGTGGGCAGCAG
TCAGTCTCCAATAAGCTTCTGGCCTGGAGCGGGGTCCTGGAGTGGCAAGAGAAACCCAAACCTGCCTCAGTGGATGCCAACACCAAGCTG
ACGCGGTCACTGCCCTGCCAGGTCTACGTGAATCATGGCGAGAACCTGAAGACGGAGCAGTGGCCCCAGAAGCTGATCATGCAGCTCATC
CCCCAGCAGCTGCTGACCACCCTGGGCCCTTTGTTCCGGAACTCAAGGATGGTCCAGTTCCATTTCACCAACAAGGACCTGGAGTCTCTC
AAAGGCCTCTACCGCATCATGGGCAACGGCTTCAACGGGAAGCTGCTTGCCGAGCGGGATGGAGTGAAAAAGAGAAGTCAGGAGCTGGCC
ATGGAGAAGGACACTTTGAAGCGGCAGCTCTTTGAGTGTGAACACCTCATTTGCCAAAGAGACACCATCCTCTCTGAGCGCACTCGCGAT
GTGGAGAGCCTGGCCCAGACCCTGGAAGAATACAGAGTGACGACGCAGGAACTGAGGCTGGAGATTTCACGCCTGGAGGAGCAGCTGAGT
CAGACCTATGAGGGGCCCGATGAGCTACCTGAAGGGGCCCAGCTGAGAAGAGTGGGCTGGACCGAGCTGCTACCCCCATCGCTGGGCTTG
GAGATCGAGGCCATTCGACAGAAACAGGAAGTGGCAACTGCTGATCTCTCCAACCCTCTGTGTGGGGTGTGGCAGTGGGAGGAAGTCATC
CATGAGACCAGTGAGGAAACTGAGTTTCCATCTGAAGCCCCAGCTGGGGGACAGAGAAACTTCCAGGGAGAGCCAGCGCACCCTGAAGAA
GGAAGGAAGGAGCCATCCATGTGGTTGACCAGAAGAGAGGAAGAGGAGGATGCAGAGAGCCAGGTCACGGCTGATCTCCCTGTCCCTCTA
GGAGCCCCTCGCCCTGGAGACATCCCAGAAAACCCTCCAGAGAGACCTGCGCGGCGGGAACTCCAGCAAGCCCTGGTGCCTGTGATGAAA
AAGCTGGTCCCAGTCAGGAGGAGGGCCTGGGGCCAGCTCTGCCTGCCCCCACAGCGGCTCAGAGTCACTCGACATCCACTGATCCCAGCT
CCTGTCCTGGGCCTGCTGCTGCTGCTGCTGCTCTCTGTCCTGCTGCTTGGCCCGTCCCCACCTCCCACCTGGCCCCACCTCCAGCTCTGC
TACCTCCAGCCCCCTCCAGTGTGAGAGGCTCTACTTGCCCCTCAGAGCAGTGTCTAGCTCAATAAATCCCCTGGCCCTCTCTCCACTGGG
ATCCCCATTGTTAGTCCACTGTTGCGCAGGCTTACCCTAGATAGAGTACAGGGGATCCACATCCCTGTATTTTTATGTGAAGTCTCCTAG
TTTTTTAATGCTGACATTTCTTAACAATAGCAAAACTCCCCCAGTAATGGATTAAGCACTAAGGATTATTCCCTCACAAAACAAGCCTGG
CGAGGGCAGCTGTGGGCACACAGCTAAGTCTCGGTTGCCTTGGGGTCAGGGCCTCAGTGATTCTCCTGTCCCCTCCCTCATGCTCAGGAG
TTGGCAGTTGTAGCTTCCTACATCACATCTGCGGGAAACGGAAATTTCTTCCTTCCTTTTTATAAAGAGAGGCAGTAGCCTCAGTGTGCA

>52730_52730_4_MED25-CCDC155_MED25_chr19_50335672_ENST00000538643_CCDC155_chr19_49910143_ENST00000447857_length(amino acids)=577AA_BP=281
MVPGSEGPARAGSVVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDVPGNLSAAQVAAQNAVEAAKNQKAGLGPRF
SPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQ
SVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESL
KGLYRIMGNGFNGKLLAERDGVKKRSQELAMEKDTLKRQLFECEHLICQRDTILSERTRDVESLAQTLEEYRVTTQELRLEISRLEEQLS
QTYEGPDELPEGAQLRRVGWTELLPPSLGLEIEAIRQKQEVATADLSNPLCGVWQWEEVIHETSEETEFPSEAPAGGQRNFQGEPAHPEE
GRKEPSMWLTRREEEEDAESQVTADLPVPLGAPRPGDIPENPPERPARRELQQALVPVMKKLVPVRRRAWGQLCLPPQRLRVTRHPLIPA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MED25-CCDC155

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Hgene	MED25	chr19:50335672	chr19:49910142	ENST00000312865	+	13	18	1_226	494.0	748.0	the Mediator complex
Hgene	MED25	chr19:50335672	chr19:49910142	ENST00000538643	+	8	13	1_226	281.0	535.0	the Mediator complex
Hgene	MED25	chr19:50335672	chr19:49910143	ENST00000312865	+	13	18	1_226	494.0	748.0	the Mediator complex
Hgene	MED25	chr19:50335672	chr19:49910143	ENST00000538643	+	8	13	1_226	281.0	535.0	the Mediator complex

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	MED25	chr19:50335672	chr19:49910142	ENST00000312865	+	13	18	395_545	494.0	748.0	CREBBP
Hgene	MED25	chr19:50335672	chr19:49910142	ENST00000538643	+	8	13	395_545	281.0	535.0	CREBBP
Hgene	MED25	chr19:50335672	chr19:49910143	ENST00000312865	+	13	18	395_545	494.0	748.0	CREBBP
Hgene	MED25	chr19:50335672	chr19:49910143	ENST00000538643	+	8	13	395_545	281.0	535.0	CREBBP
Hgene	MED25	chr19:50335672	chr19:49910142	ENST00000312865	+	13	18	564_653	494.0	748.0	RARA
Hgene	MED25	chr19:50335672	chr19:49910142	ENST00000312865	+	13	18	640_707	494.0	748.0	RARA
Hgene	MED25	chr19:50335672	chr19:49910142	ENST00000538643	+	8	13	564_653	281.0	535.0	RARA
Hgene	MED25	chr19:50335672	chr19:49910142	ENST00000538643	+	8	13	640_707	281.0	535.0	RARA
Hgene	MED25	chr19:50335672	chr19:49910143	ENST00000312865	+	13	18	564_653	494.0	748.0	RARA
Hgene	MED25	chr19:50335672	chr19:49910143	ENST00000312865	+	13	18	640_707	494.0	748.0	RARA
Hgene	MED25	chr19:50335672	chr19:49910143	ENST00000538643	+	8	13	564_653	281.0	535.0	RARA
Hgene	MED25	chr19:50335672	chr19:49910143	ENST00000538643	+	8	13	640_707	281.0	535.0	RARA
Hgene	MED25	chr19:50335672	chr19:49910142	ENST00000312865	+	13	18	389_543	494.0	748.0	VP16
Hgene	MED25	chr19:50335672	chr19:49910142	ENST00000538643	+	8	13	389_543	281.0	535.0	VP16
Hgene	MED25	chr19:50335672	chr19:49910143	ENST00000312865	+	13	18	389_543	494.0	748.0	VP16
Hgene	MED25	chr19:50335672	chr19:49910143	ENST00000538643	+	8	13	389_543	281.0	535.0	VP16

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for MED25-CCDC155

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for MED25-CCDC155

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source