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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MED25-EEF2 (FusionGDB2 ID:52731)

Fusion Gene Summary for MED25-EEF2

Fusion gene summary

Fusion gene information	Fusion gene name: MED25-EEF2
	Fusion gene ID: 52731
		Hgene	Tgene
	Gene symbol	MED25	EEF2
	Gene ID	81857	1938
	Gene name	mediator complex subunit 25	eukaryotic translation elongation factor 2
	Synonyms	ACID1\|ARC92\|BVSYS\|CMT2B2\|P78\|PTOV2\|TCBAP0758	EEF-2\|EF-2\|EF2\|SCA26
	Cytomap	19q13.33	19p13.3
	Type of gene	protein-coding	protein-coding
	Description	mediator of RNA polymerase II transcription subunit 25ARC/mediator transcriptional coactivator subunitactivator interaction domain-containing protein 1activator-recruited cofactor 92 kDa componentmediator of RNA polymerase II transcription, subunit 25	elongation factor 2epididymis secretory sperm binding proteinpolypeptidyl-tRNA translocase
	Modification date	20200328	20200313
	UniProtAcc	Q71SY5	Q96G04
	Ensembl transtripts involved in fusion gene	ENST00000312865, ENST00000538643,	ENST00000600720, ENST00000309311,
Fusion gene scores	* DoF score	10 X 6 X 6=360	17 X 23 X 7=2737
	# samples	13	28
	** MAII score	log2(13/360*10)=-1.46948528330122 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(28/2737*10)=-3.28909670241999 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MED25 [Title/Abstract] AND EEF2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MED25(50339202)-EEF2(3976745), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MED25	GO:0045944	positive regulation of transcription by RNA polymerase II	17641689

Fusion gene breakpoints across MED25 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across EEF2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	TCGA-IN-8462-11A	MED25	chr19	50339202	+	EEF2	chr19	3976745	-

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Fusion Gene ORF analysis for MED25-EEF2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000312865	ENST00000600720	MED25	chr19	50339202	+	EEF2	chr19	3976745	-
5CDS-intron	ENST00000538643	ENST00000600720	MED25	chr19	50339202	+	EEF2	chr19	3976745	-
In-frame	ENST00000312865	ENST00000309311	MED25	chr19	50339202	+	EEF2	chr19	3976745	-
In-frame	ENST00000538643	ENST00000309311	MED25	chr19	50339202	+	EEF2	chr19	3976745	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000312865

MED25

chr19

50339202

ENST00000309311

EEF2

chr19

3976745

2710

2018

2035

660

ENST00000538643

MED25

chr19

50339202

ENST00000309311

EEF2

chr19

3976745

2018

1326

1343

447

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000312865	ENST00000309311	MED25	chr19	50339202	+	EEF2	chr19	3976745	-	0.02532822	0.9746718
ENST00000538643	ENST00000309311	MED25	chr19	50339202	+	EEF2	chr19	3976745	-	0.026184613	0.9738153

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Fusion Genomic Features for MED25-EEF2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MED25-EEF2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:50339202/chr19:3976745)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MED25 Q71SY5	EEF2 Q96G04
FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription. {ECO:0000269\|PubMed:14657022, ECO:0000269\|PubMed:14983011, ECO:0000269\|PubMed:17641689}.	FUNCTION: Catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on 'Lys-525'. {ECO:0000269\|PubMed:25231979}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MED25

chr19:50339202

chr19:3976745

ENST00000312865

200_381

655

748.0

Compositional bias

Note=Pro-rich

Hgene

MED25

chr19:50339202

chr19:3976745

ENST00000538643

200_381

442

535.0

Compositional bias

Note=Pro-rich

Hgene

MED25

chr19:50339202

chr19:3976745

ENST00000312865

646_650

655

748.0

Motif

Note=LXXLL motif

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MED25

chr19:50339202

chr19:3976745

ENST00000312865

565_735

655

748.0

Compositional bias

Note=Pro-rich

Hgene

MED25

chr19:50339202

chr19:3976745

ENST00000538643

565_735

442

535.0

Compositional bias

Note=Pro-rich

Hgene

MED25

chr19:50339202

chr19:3976745

ENST00000538643

646_650

442

535.0

Motif

Note=LXXLL motif

Tgene

EEF2

chr19:50339202

chr19:3976745

ENST00000309311

17_362

794

859.0

Domain

tr-type G

Tgene

EEF2

chr19:50339202

chr19:3976745

ENST00000309311

104_108

794

859.0

Nucleotide binding

GTP

Tgene

EEF2

chr19:50339202

chr19:3976745

ENST00000309311

158_161

794

859.0

Nucleotide binding

GTP

Tgene

EEF2

chr19:50339202

chr19:3976745

ENST00000309311

26_33

794

859.0

Nucleotide binding

GTP

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Fusion Gene Sequence for MED25-EEF2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>52731_52731_1_MED25-EEF2_MED25_chr19_50339202_ENST00000312865_EEF2_chr19_3976745_ENST00000309311_length(transcript)=2710nt_BP=2018nt
ATTCCGCGGCGTCGGCTGCGGCTGCAGTGGTGGTGGCGGGTACCGCACGGGGTATGGTCCCCGGGTCCGAGGGCCCGGCCCGCGCCGGGA
GCGTGGTGGCCGACGTGGTGTTTGTGATTGAGGGTACGGCCAACCTGGGACCCTACTTCGAGGGGCTCCGCAAGCACTACCTGCTCCCGG
CCATCGAGTATTTTAATGGTGGTCCTCCTGCTGAGACGGACTTCGGGGGAGACTATGGGGGGACCCAGTACAGCCTCGTGGTGTTCAACA
CAGTGGACTGCGCTCCCGAGTCCTACGTACAATGTCACGCTCCCACCAGCAGCGCCTATGAGTTTGTCACCTGGCTCGATGGCATTAAGT
TCATGGGCGGGGGTGGTGAGAGCTGCAGCCTCATCGCGGAAGGACTCAGCACAGCCTTGCAGCTGTTTGATGACTTCAAGAAGATGCGCG
AGCAGATTGGCCAGACGCACCGGGTCTGCCTCCTCATCTGCAACTCACCCCCATACTTGTTGCCTGCTGTTGAGAGCACCACGTACTCTG
GATGCACAACTGAGAATCTTGTGCAGCAGATTGGGGAGCGGGGGATCCACTTCTCCATTGTGTCTCCCCGGAAGCTGCCTGCGCTTCGGC
TTCTGTTTGAGAAGGCAGCCCCCCCGGCCTTGCTGGAGCCGCTGCAGCCTCCGACAGATGTGAGCCAGGACCCGAGGCACATGGTGCTGG
TTCGGGGACTCGTGCTGCCTGTTGGGGGTGGCTCAGCCCCAGGCCCCCTCCAGTCAAAGCAGCCAGTCCCCCTGCCTCCCGCCGCACCCT
CAGGTGCCACTCTCTCAGCAGCCCCCCAGCAGCCTCTGCCCCCCGTCCCCCCGCAGTACCAGGTTCCCGGGAACCTGAGTGCAGCTCAGG
TGGCCGCGCAGAATGCAGTGGAGGCTGCCAAGAACCAGAAGGCTGGGCTGGGCCCTCGCTTCTCGCCCATCACCCCTCTCCAACAAGCTG
CTCCCGGAGTGGGTCCCCCCTTCAGCCAGGCCCCAGCTCCCCAACTACCCCCAGGACCCCCTGGCGCCCCCAAGCCACCACCTGCTTCCC
AGCCCAGTCTGGTCTCCACTGTGGCCCCTGGCTCCGGCCTGGCTCCCACGGCACAGCCCGGGGCACCGTCCATGGCAGGCACTGTGGCCC
CAGGAGGGGTGAGCGGCCCTTCCCCAGCCCAGCTGGGAGCCCCAGCCCTCGGTGGGCAGCAGTCAGTCTCCAATAAGCTTCTGGCCTGGA
GCGGGGTCCTGGAGTGGCAAGAGAAACCCAAACCTGCCTCAGTGGATGCCAACACCAAGCTGACGCGGTCACTGCCCTGCCAGGTCTACG
TGAATCATGGCGAGAACCTGAAGACGGAGCAGTGGCCCCAGAAGCTGATCATGCAGCTCATCCCCCAGCAGCTGCTGACCACCCTGGGCC
CTTTGTTCCGGAACTCAAGGATGGTCCAGTTCCATTTCACCAACAAGGACCTGGAGTCTCTCAAAGGCCTCTACCGCATCATGGGCAACG
GCTTCGCGGGCTGCGTGCACTTCCCCCACACGGCGCCCTGTGAGGTGCGCGTGCTCATGCTCCTGTACTCGTCCAAGAAGAAGATCTTCA
TGGGCCTCATCCCCTACGACCAGAGCGGCTTCGTCAACGGCATCCGGCAGGTCATCACCAACCACAAGCAGGTCCAGCAGCAGAAGCTGG
AGCAGCAGCAGCGAGGAATGGGGGGACAGCAGGCACCCCCAGGGCTGGGGCCCATTCTGGAGGACCAAGCCAGGCCCTCACAGAATCTGC
TCCAGCTCCGCCCACCGCAGCCCCAGCCTCAGGGTACCGTAGGGGCCTCTGGGGCCACGGGGCAGCCCCAGCCCCAAGGTACTGCCCAGC
CCCCGCCAGGTGCCCCTCAAGGCCCTCCTGGAGCAGCTTCTGGCCCACCCCCTCCTGGACCCATCCTTCGGCCCCAGAACCCTGGGGCCA
ACCCTCAGCTGCGAAGCCTCCTCCTCAACCCACCACCGGCTTCACCGCTGACCTGAGGTCCAACACGGGCGGCCAGGCGTTCCCCCAGTG
TGTGTTTGACCACTGGCAGATCCTGCCCGGAGACCCCTTCGACAACAGCAGCCGCCCCAGCCAGGTGGTGGCGGAGACCCGCAAGCGCAA
GGGCCTGAAAGAAGGCATCCCTGCCCTGGACAACTTCCTGGACAAATTGTAGGCGGCCCTTCCTGCAGCGCCTGCCGCCCCGGGGACTCG
CAGCACCCACAGCACCACGTCCTCGAATTCTCAGACGACACCTGGAGACTGTCCCGACACAGCGACGCTCCCCTGAGAGGTTTCTGGGGC
CCGCTGCGTGCCATCACTCAACCATAACACTTGATGCCGTTTCTTTCAATATTTATTTCCAGAGTCCGGAGGCAGCAGACACGCCCTCTT
AGTAGGGACTTAATGGGCCGGTCGGGGAGGGGGAGGCGGGATGGGACACCCAACACTTTTTCCATTTCTTCAGAGGGAAACTCAGATGTC
CAAACTAATTTTAACAAACGCATTAAGAGGTTTATTTGGGTACATGGCCCGCAGTGGCTTTTGCCCCAGAAAGGGGAAAGGAACACGCGG
GTAGATGATTTCTAGCAGGCAGGAAGTCCTGTGCGGTGTCACCATGAGCACCTCCAGCTGTACTAGTGCCATTGGAATAATAAATTTGAT

>52731_52731_1_MED25-EEF2_MED25_chr19_50339202_ENST00000312865_EEF2_chr19_3976745_ENST00000309311_length(amino acids)=660AA_BP=
MVPGSEGPARAGSVVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSS
AYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTENLVQQIGERGIHF
SIVSPRKLPALRLLFEKAAPPALLEPLQPPTDVSQDPRHMVLVRGLVLPVGGGSAPGPLQSKQPVPLPPAAPSGATLSAAPQQPLPPVPP
QYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTA
QPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIM
QLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQV
ITNHKQVQQQKLEQQQRGMGGQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGTVGASGATGQPQPQGTAQPPPGAPQGPPGAASGPPP

--------------------------------------------------------------
>52731_52731_2_MED25-EEF2_MED25_chr19_50339202_ENST00000538643_EEF2_chr19_3976745_ENST00000309311_length(transcript)=2018nt_BP=1326nt
ATGGTCCCCGGGTCCGAGGGCCCGGCCCGCGCCGGGAGCGTGGTGGCCGACGTGGTGTTTGTGATTGAGGGTACGGCCAACCTGGGACCC
TACTTCGAGGGGCTCCGCAAGCACTACCTGCTCCCGGCCATCGAGTATTTTAATGGTGGTCCTCCTGCTGAGACGGACTTCGGGGGAGAC
GTTCCCGGGAACCTGAGTGCAGCTCAGGTGGCCGCGCAGAATGCAGTGGAGGCTGCCAAGAACCAGAAGGCTGGGCTGGGCCCTCGCTTC
TCGCCCATCACCCCTCTCCAACAAGCTGCTCCCGGAGTGGGTCCCCCCTTCAGCCAGGCCCCAGCTCCCCAACTACCCCCAGGACCCCCT
GGCGCCCCCAAGCCACCACCTGCTTCCCAGCCCAGTCTGGTCTCCACTGTGGCCCCTGGCTCCGGCCTGGCTCCCACGGCACAGCCCGGG
GCACCGTCCATGGCAGGCACTGTGGCCCCAGGAGGGGTGAGCGGCCCTTCCCCAGCCCAGCTGGGAGCCCCAGCCCTCGGTGGGCAGCAG
TCAGTCTCCAATAAGCTTCTGGCCTGGAGCGGGGTCCTGGAGTGGCAAGAGAAACCCAAACCTGCCTCAGTGGATGCCAACACCAAGCTG
ACGCGGTCACTGCCCTGCCAGGTCTACGTGAATCATGGCGAGAACCTGAAGACGGAGCAGTGGCCCCAGAAGCTGATCATGCAGCTCATC
CCCCAGCAGCTGCTGACCACCCTGGGCCCTTTGTTCCGGAACTCAAGGATGGTCCAGTTCCATTTCACCAACAAGGACCTGGAGTCTCTC
AAAGGCCTCTACCGCATCATGGGCAACGGCTTCGCGGGCTGCGTGCACTTCCCCCACACGGCGCCCTGTGAGGTGCGCGTGCTCATGCTC
CTGTACTCGTCCAAGAAGAAGATCTTCATGGGCCTCATCCCCTACGACCAGAGCGGCTTCGTCAACGGCATCCGGCAGGTCATCACCAAC
CACAAGCAGGTCCAGCAGCAGAAGCTGGAGCAGCAGCAGCGAGGAATGGGGGGACAGCAGGCACCCCCAGGGCTGGGGCCCATTCTGGAG
GACCAAGCCAGGCCCTCACAGAATCTGCTCCAGCTCCGCCCACCGCAGCCCCAGCCTCAGGGTACCGTAGGGGCCTCTGGGGCCACGGGG
CAGCCCCAGCCCCAAGGTACTGCCCAGCCCCCGCCAGGTGCCCCTCAAGGCCCTCCTGGAGCAGCTTCTGGCCCACCCCCTCCTGGACCC
ATCCTTCGGCCCCAGAACCCTGGGGCCAACCCTCAGCTGCGAAGCCTCCTCCTCAACCCACCACCGGCTTCACCGCTGACCTGAGGTCCA
ACACGGGCGGCCAGGCGTTCCCCCAGTGTGTGTTTGACCACTGGCAGATCCTGCCCGGAGACCCCTTCGACAACAGCAGCCGCCCCAGCC
AGGTGGTGGCGGAGACCCGCAAGCGCAAGGGCCTGAAAGAAGGCATCCCTGCCCTGGACAACTTCCTGGACAAATTGTAGGCGGCCCTTC
CTGCAGCGCCTGCCGCCCCGGGGACTCGCAGCACCCACAGCACCACGTCCTCGAATTCTCAGACGACACCTGGAGACTGTCCCGACACAG
CGACGCTCCCCTGAGAGGTTTCTGGGGCCCGCTGCGTGCCATCACTCAACCATAACACTTGATGCCGTTTCTTTCAATATTTATTTCCAG
AGTCCGGAGGCAGCAGACACGCCCTCTTAGTAGGGACTTAATGGGCCGGTCGGGGAGGGGGAGGCGGGATGGGACACCCAACACTTTTTC
CATTTCTTCAGAGGGAAACTCAGATGTCCAAACTAATTTTAACAAACGCATTAAGAGGTTTATTTGGGTACATGGCCCGCAGTGGCTTTT
GCCCCAGAAAGGGGAAAGGAACACGCGGGTAGATGATTTCTAGCAGGCAGGAAGTCCTGTGCGGTGTCACCATGAGCACCTCCAGCTGTA

>52731_52731_2_MED25-EEF2_MED25_chr19_50339202_ENST00000538643_EEF2_chr19_3976745_ENST00000309311_length(amino acids)=447AA_BP=
MVPGSEGPARAGSVVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDVPGNLSAAQVAAQNAVEAAKNQKAGLGPRF
SPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQ
SVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESL
KGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQQRGMGGQQAPPGLGPILE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MED25-EEF2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Hgene	MED25	chr19:50339202	chr19:3976745	ENST00000312865	+	16	18	395_545	655.0	748.0	CREBBP
Hgene	MED25	chr19:50339202	chr19:3976745	ENST00000312865	+	16	18	564_653	655.0	748.0	RARA
Hgene	MED25	chr19:50339202	chr19:3976745	ENST00000312865	+	16	18	1_226	655.0	748.0	the Mediator complex
Hgene	MED25	chr19:50339202	chr19:3976745	ENST00000538643	+	11	13	1_226	442.0	535.0	the Mediator complex
Hgene	MED25	chr19:50339202	chr19:3976745	ENST00000312865	+	16	18	389_543	655.0	748.0	VP16

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	MED25	chr19:50339202	chr19:3976745	ENST00000538643	+	11	13	395_545	442.0	535.0	CREBBP
Hgene	MED25	chr19:50339202	chr19:3976745	ENST00000312865	+	16	18	640_707	655.0	748.0	RARA
Hgene	MED25	chr19:50339202	chr19:3976745	ENST00000538643	+	11	13	564_653	442.0	535.0	RARA
Hgene	MED25	chr19:50339202	chr19:3976745	ENST00000538643	+	11	13	640_707	442.0	535.0	RARA
Hgene	MED25	chr19:50339202	chr19:3976745	ENST00000538643	+	11	13	389_543	442.0	535.0	VP16

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for MED25-EEF2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for MED25-EEF2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source