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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MED25-MAPK15 (FusionGDB2 ID:52733)

Fusion Gene Summary for MED25-MAPK15

check button Fusion gene summary
Fusion gene informationFusion gene name: MED25-MAPK15
Fusion gene ID: 52733
HgeneTgene
Gene symbol

MED25

MAPK15

Gene ID

81857

225689

Gene namemediator complex subunit 25mitogen-activated protein kinase 15
SynonymsACID1|ARC92|BVSYS|CMT2B2|P78|PTOV2|TCBAP0758ERK7|ERK8
Cytomap

19q13.33

8q24.3

Type of geneprotein-codingprotein-coding
Descriptionmediator of RNA polymerase II transcription subunit 25ARC/mediator transcriptional coactivator subunitactivator interaction domain-containing protein 1activator-recruited cofactor 92 kDa componentmediator of RNA polymerase II transcription, subunit 25mitogen-activated protein kinase 15ERK-7ERK-8MAP kinase 15MAPK 15extracellular regulated kinase 8 deltaextracellular signal-regulated kinase 7extracellular signal-regulated kinase 8
Modification date2020032820200313
UniProtAcc

Q71SY5

.
Ensembl transtripts involved in fusion geneENST00000312865, ENST00000538643, 
ENST00000338033, ENST00000395107, 
ENST00000395108, 
Fusion gene scores* DoF score10 X 6 X 6=3601 X 1 X 1=1
# samples 131
** MAII scorelog2(13/360*10)=-1.46948528330122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: MED25 [Title/Abstract] AND MAPK15 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMED25(50335672)-MAPK15(144799864), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMED25

GO:0045944

positive regulation of transcription by RNA polymerase II

17641689

TgeneMAPK15

GO:0006974

cellular response to DNA damage stimulus

19166846

TgeneMAPK15

GO:0008284

positive regulation of cell proliferation

20638370

TgeneMAPK15

GO:0010506

regulation of autophagy

22948227

TgeneMAPK15

GO:0032212

positive regulation of telomere maintenance via telomerase

21531765

TgeneMAPK15

GO:0046777

protein autophosphorylation

11875070

TgeneMAPK15

GO:0051973

positive regulation of telomerase activity

21531765

TgeneMAPK15

GO:0090494

dopamine uptake

28842414

TgeneMAPK15

GO:1904355

positive regulation of telomere capping

21531765


check buttonFusion gene breakpoints across MED25 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MAPK15 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-OL-A66I-01AMED25chr19

50335672

-MAPK15chr8

144799864

+
ChimerDB4BRCATCGA-OL-A66I-01AMED25chr19

50335672

+MAPK15chr8

144799864

+


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Fusion Gene ORF analysis for MED25-MAPK15

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000312865ENST00000338033MED25chr19

50335672

+MAPK15chr8

144799864

+
In-frameENST00000312865ENST00000395107MED25chr19

50335672

+MAPK15chr8

144799864

+
In-frameENST00000312865ENST00000395108MED25chr19

50335672

+MAPK15chr8

144799864

+
In-frameENST00000538643ENST00000338033MED25chr19

50335672

+MAPK15chr8

144799864

+
In-frameENST00000538643ENST00000395107MED25chr19

50335672

+MAPK15chr8

144799864

+
In-frameENST00000538643ENST00000395108MED25chr19

50335672

+MAPK15chr8

144799864

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000312865MED25chr1950335672+ENST00000338033MAPK15chr8144799864+331115355331031016
ENST00000312865MED25chr1950335672+ENST00000395107MAPK15chr8144799864+23031535532302750
ENST00000312865MED25chr1950335672+ENST00000395108MAPK15chr8144799864+22341535532233727
ENST00000538643MED25chr1950335672+ENST00000338033MAPK15chr8144799864+261984302411803
ENST00000538643MED25chr1950335672+ENST00000395107MAPK15chr8144799864+161184301610536
ENST00000538643MED25chr1950335672+ENST00000395108MAPK15chr8144799864+154284301541513

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000312865ENST00000338033MED25chr1950335672+MAPK15chr8144799864+0.0037325940.9962674
ENST00000312865ENST00000395107MED25chr1950335672+MAPK15chr8144799864+0.0184042750.9815957
ENST00000312865ENST00000395108MED25chr1950335672+MAPK15chr8144799864+0.014509660.9854903
ENST00000538643ENST00000338033MED25chr1950335672+MAPK15chr8144799864+0.0155564350.98444355
ENST00000538643ENST00000395107MED25chr1950335672+MAPK15chr8144799864+0.0190311630.98096883
ENST00000538643ENST00000395108MED25chr1950335672+MAPK15chr8144799864+0.0104510810.9895489

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Fusion Genomic Features for MED25-MAPK15


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MED25-MAPK15


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:50335672/chr8:144799864)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MED25

Q71SY5

.
FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription. {ECO:0000269|PubMed:14657022, ECO:0000269|PubMed:14983011, ECO:0000269|PubMed:17641689}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMED25chr19:50335672chr8:144799864ENST00000312865+1318200_381494748.0Compositional biasNote=Pro-rich
TgeneMAPK15chr19:50335672chr8:144799864ENST00000338033014175_17722545.0MotifNote=TXY
TgeneMAPK15chr19:50335672chr8:144799864ENST0000039510708175_17722278.0MotifNote=TXY
TgeneMAPK15chr19:50335672chr8:144799864ENST0000039510808175_17722255.0MotifNote=TXY
TgeneMAPK15chr19:50335672chr8:144799864ENST0000033803301419_2722545.0Nucleotide bindingATP
TgeneMAPK15chr19:50335672chr8:144799864ENST000003951070819_2722278.0Nucleotide bindingATP
TgeneMAPK15chr19:50335672chr8:144799864ENST000003951080819_2722255.0Nucleotide bindingATP
TgeneMAPK15chr19:50335672chr8:144799864ENST00000338033014265_28522545.0RegionNecessary to interact with ESRRA%2C to regulate its subcellular localization and to inhibit its transcriptional activity
TgeneMAPK15chr19:50335672chr8:144799864ENST0000039510708265_28522278.0RegionNecessary to interact with ESRRA%2C to regulate its subcellular localization and to inhibit its transcriptional activity
TgeneMAPK15chr19:50335672chr8:144799864ENST0000039510808265_28522255.0RegionNecessary to interact with ESRRA%2C to regulate its subcellular localization and to inhibit its transcriptional activity
TgeneMAPK15chr19:50335672chr8:144799864ENST00000338033014371_37522545.0RepeatPXXXP motif
TgeneMAPK15chr19:50335672chr8:144799864ENST00000338033014378_38222545.0RepeatPXXXP motif
TgeneMAPK15chr19:50335672chr8:144799864ENST0000039510708371_37522278.0RepeatPXXXP motif
TgeneMAPK15chr19:50335672chr8:144799864ENST0000039510708378_38222278.0RepeatPXXXP motif
TgeneMAPK15chr19:50335672chr8:144799864ENST0000039510808371_37522255.0RepeatPXXXP motif
TgeneMAPK15chr19:50335672chr8:144799864ENST0000039510808378_38222255.0RepeatPXXXP motif

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMED25chr19:50335672chr8:144799864ENST00000312865+1318565_735494748.0Compositional biasNote=Pro-rich
HgeneMED25chr19:50335672chr8:144799864ENST00000538643+813200_381281535.0Compositional biasNote=Pro-rich
HgeneMED25chr19:50335672chr8:144799864ENST00000538643+813565_735281535.0Compositional biasNote=Pro-rich
HgeneMED25chr19:50335672chr8:144799864ENST00000312865+1318646_650494748.0MotifNote=LXXLL motif
HgeneMED25chr19:50335672chr8:144799864ENST00000538643+813646_650281535.0MotifNote=LXXLL motif
TgeneMAPK15chr19:50335672chr8:144799864ENST0000033803301413_30422545.0DomainProtein kinase
TgeneMAPK15chr19:50335672chr8:144799864ENST000003951070813_30422278.0DomainProtein kinase
TgeneMAPK15chr19:50335672chr8:144799864ENST000003951080813_30422255.0DomainProtein kinase


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Fusion Gene Sequence for MED25-MAPK15


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>52733_52733_1_MED25-MAPK15_MED25_chr19_50335672_ENST00000312865_MAPK15_chr8_144799864_ENST00000338033_length(transcript)=3311nt_BP=1535nt
ATTCCGCGGCGTCGGCTGCGGCTGCAGTGGTGGTGGCGGGTACCGCACGGGGTATGGTCCCCGGGTCCGAGGGCCCGGCCCGCGCCGGGA
GCGTGGTGGCCGACGTGGTGTTTGTGATTGAGGGTACGGCCAACCTGGGACCCTACTTCGAGGGGCTCCGCAAGCACTACCTGCTCCCGG
CCATCGAGTATTTTAATGGTGGTCCTCCTGCTGAGACGGACTTCGGGGGAGACTATGGGGGGACCCAGTACAGCCTCGTGGTGTTCAACA
CAGTGGACTGCGCTCCCGAGTCCTACGTACAATGTCACGCTCCCACCAGCAGCGCCTATGAGTTTGTCACCTGGCTCGATGGCATTAAGT
TCATGGGCGGGGGTGGTGAGAGCTGCAGCCTCATCGCGGAAGGACTCAGCACAGCCTTGCAGCTGTTTGATGACTTCAAGAAGATGCGCG
AGCAGATTGGCCAGACGCACCGGGTCTGCCTCCTCATCTGCAACTCACCCCCATACTTGTTGCCTGCTGTTGAGAGCACCACGTACTCTG
GATGCACAACTGAGAATCTTGTGCAGCAGATTGGGGAGCGGGGGATCCACTTCTCCATTGTGTCTCCCCGGAAGCTGCCTGCGCTTCGGC
TTCTGTTTGAGAAGGCAGCCCCCCCGGCCTTGCTGGAGCCGCTGCAGCCTCCGACAGATGTGAGCCAGGACCCGAGGCACATGGTGCTGG
TTCGGGGACTCGTGCTGCCTGTTGGGGGTGGCTCAGCCCCAGGCCCCCTCCAGTCAAAGCAGCCAGTCCCCCTGCCTCCCGCCGCACCCT
CAGGTGCCACTCTCTCAGCAGCCCCCCAGCAGCCTCTGCCCCCCGTCCCCCCGCAGTACCAGGTTCCCGGGAACCTGAGTGCAGCTCAGG
TGGCCGCGCAGAATGCAGTGGAGGCTGCCAAGAACCAGAAGGCTGGGCTGGGCCCTCGCTTCTCGCCCATCACCCCTCTCCAACAAGCTG
CTCCCGGAGTGGGTCCCCCCTTCAGCCAGGCCCCAGCTCCCCAACTACCCCCAGGACCCCCTGGCGCCCCCAAGCCACCACCTGCTTCCC
AGCCCAGTCTGGTCTCCACTGTGGCCCCTGGCTCCGGCCTGGCTCCCACGGCACAGCCCGGGGCACCGTCCATGGCAGGCACTGTGGCCC
CAGGAGGGGTGAGCGGCCCTTCCCCAGCCCAGCTGGGAGCCCCAGCCCTCGGTGGGCAGCAGTCAGTCTCCAATAAGCTTCTGGCCTGGA
GCGGGGTCCTGGAGTGGCAAGAGAAACCCAAACCTGCCTCAGTGGATGCCAACACCAAGCTGACGCGGTCACTGCCCTGCCAGGTCTACG
TGAATCATGGCGAGAACCTGAAGACGGAGCAGTGGCCCCAGAAGCTGATCATGCAGCTCATCCCCCAGCAGCTGCTGACCACCCTGGGCC
CTTTGTTCCGGAACTCAAGGATGGTCCAGTTCCATTTCACCAACAAGGACCTGGAGTCTCTCAAAGGCCTCTACCGCATCATGGGCAACG
GCTTCGCCTATGGCATTGTGTGGAAGGCAGTGGACCGGAGGACTGGTGAGGTCGTGGCCATCAAGAAAATCTTTGATGCTTTTAGGGATA
AGACAGATGCCCAGAGAACATTCCGGGAAATCACGCTCCTCCAGGAGTTTGGGGACCATCCCAACATCATCAGCCTCCTTGACGTGATCC
GGGCAGAGAACGACAGGGACATTTACCTGGTGTTTGAGTTTATGGACACTGACCTGAACGCAGTCATCCGGAAGGGCGGCCTGCTGCAGG
ACGTCCACGTGCGCTCCATCTTCTACCAGCTCCTGCGGGCCACCCGGTTCCTCCACTCGGGGCACGTTGTGCACCGGGACCAGAAGCCGT
CCAATGTGCTCCTGGATGCCAACTGCACAGTGAAGCTGTGTGACTTTGGCCTGGCCCGCTCCCTGGGCGACCTCCCCGAGGGGCCTGAGG
ACCAGGCCGTGACAGAGTACGTGGCCACACGCTGGTACCGAGCACCGGAGGTGCTGCTCTCTTCGCACCGATACACCCTTGGGGTGGACA
TGTGGAGTCTGGGCTGTATCCTGGGGGAGATGCTGCGGGGGAGACCCCTGTTCCCCGGCACGTCCACCCTCCACCAGCTGGAGCTGATCC
TGGAGACCATCCCACCGCCATCTGAGGAGGACCTCCTGGCTCTCGGCTCAGGCTGCCGTGCCTCTGTGCTGCACCAGCTGGGGTCCCGGC
CACGACAGACGCTGGATGCCCTCCTACCGCCAGACACCTCCCCAGAGGCCTTGGACCTCCTTAGGCGACTCCTGGTGTTCGCCCCGGACA
AGCGGTTAAGCGCGACCCAGGCACTGCAGCACCCCTACGTGCAGAGGTTCCACTGCCCCAGCGACGAGTGGGCACGAGAGGCAGATGTGC
GGCCCCGGGCACACGAAGGGGTCCAGCTCTCTGTGCCTGAGTACCGCAGCCGCGTCTATCAGATGATCCTGGAGTGTGGAGGCAGCAGCG
GCACCTCGAGAGAGAAGGGCCCGGAGGGTGTCTCCCCAAGCCAGGCACACCTGCACAAACCCAGAGCCGACCCTCAGCTGCCTTCTAGGA
CACCTGTGCAGGGTCCCAGACCCAGGCCCCAGAGCAGCCCAGGCCATGACCCTGCCGAGCACGAGTCCCCCCGTGCAGCCAAGAACGTTC
CCAGGCAGAACTCCGCTCCCCTGCTCCAAACTGCTCTCCTAGGGAATGGGGAAAGGCCCCCTGGGGCGAAGGAAGCGCCCCCCTTGACAC
TCTCGCTGGTGAAGCCAAGCGGGAGGGGAGCTGCGCCCTCCCTGACCTCCCAGGCTGCGGCTCAGGTGGCCAACCAGGCCCTGATCCGGG
GTGACTGGAACCGGGGCGGTGGGGTGAGGGTGGCCAGCGTACAACAGGTCCCTCCCCGGCTTCCTCCGGAGGCCCGGCCCGGCCGGAGGA
TGTTCAGCACCTCTGCCTTGCAGGGTGCCCAGGGGGGTGCCAGGGCTTTGCTTGGAGGCTACTCCCAAGCCTACGGGACTGTCTGCCACT
CGGCACTGGGCCACCTGCCCCTGCTGGAGGGGCACCATGTGTGAGCCGCCCTACTCCCTTCACCTGGCCCTCTGTTCCTGCCCCAGCCCC
TTCCCCAGACCCCTCTCCAGTCTCCTGCACCCCTTAGCCCTCCCTGCTTTGCCTGGCCCGTTGAAGTTCCAGGGAGCTTGCCCGGGTCTC

>52733_52733_1_MED25-MAPK15_MED25_chr19_50335672_ENST00000312865_MAPK15_chr8_144799864_ENST00000338033_length(amino acids)=1016AA_BP=260
MVPGSEGPARAGSVVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSS
AYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTENLVQQIGERGIHF
SIVSPRKLPALRLLFEKAAPPALLEPLQPPTDVSQDPRHMVLVRGLVLPVGGGSAPGPLQSKQPVPLPPAAPSGATLSAAPQQPLPPVPP
QYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTA
QPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIM
QLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFG
DHPNIISLLDVIRAENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGL
ARSLGDLPEGPEDQAVTEYVATRWYRAPEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLALGSG
CRASVLHQLGSRPRQTLDALLPPDTSPEALDLLRRLLVFAPDKRLSATQALQHPYVQRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSR
VYQMILECGGSSGTSREKGPEGVSPSQAHLHKPRADPQLPSRTPVQGPRPRPQSSPGHDPAEHESPRAAKNVPRQNSAPLLQTALLGNGE
RPPGAKEAPPLTLSLVKPSGRGAAPSLTSQAAAQVANQALIRGDWNRGGGVRVASVQQVPPRLPPEARPGRRMFSTSALQGAQGGARALL

--------------------------------------------------------------
>52733_52733_2_MED25-MAPK15_MED25_chr19_50335672_ENST00000312865_MAPK15_chr8_144799864_ENST00000395107_length(transcript)=2303nt_BP=1535nt
ATTCCGCGGCGTCGGCTGCGGCTGCAGTGGTGGTGGCGGGTACCGCACGGGGTATGGTCCCCGGGTCCGAGGGCCCGGCCCGCGCCGGGA
GCGTGGTGGCCGACGTGGTGTTTGTGATTGAGGGTACGGCCAACCTGGGACCCTACTTCGAGGGGCTCCGCAAGCACTACCTGCTCCCGG
CCATCGAGTATTTTAATGGTGGTCCTCCTGCTGAGACGGACTTCGGGGGAGACTATGGGGGGACCCAGTACAGCCTCGTGGTGTTCAACA
CAGTGGACTGCGCTCCCGAGTCCTACGTACAATGTCACGCTCCCACCAGCAGCGCCTATGAGTTTGTCACCTGGCTCGATGGCATTAAGT
TCATGGGCGGGGGTGGTGAGAGCTGCAGCCTCATCGCGGAAGGACTCAGCACAGCCTTGCAGCTGTTTGATGACTTCAAGAAGATGCGCG
AGCAGATTGGCCAGACGCACCGGGTCTGCCTCCTCATCTGCAACTCACCCCCATACTTGTTGCCTGCTGTTGAGAGCACCACGTACTCTG
GATGCACAACTGAGAATCTTGTGCAGCAGATTGGGGAGCGGGGGATCCACTTCTCCATTGTGTCTCCCCGGAAGCTGCCTGCGCTTCGGC
TTCTGTTTGAGAAGGCAGCCCCCCCGGCCTTGCTGGAGCCGCTGCAGCCTCCGACAGATGTGAGCCAGGACCCGAGGCACATGGTGCTGG
TTCGGGGACTCGTGCTGCCTGTTGGGGGTGGCTCAGCCCCAGGCCCCCTCCAGTCAAAGCAGCCAGTCCCCCTGCCTCCCGCCGCACCCT
CAGGTGCCACTCTCTCAGCAGCCCCCCAGCAGCCTCTGCCCCCCGTCCCCCCGCAGTACCAGGTTCCCGGGAACCTGAGTGCAGCTCAGG
TGGCCGCGCAGAATGCAGTGGAGGCTGCCAAGAACCAGAAGGCTGGGCTGGGCCCTCGCTTCTCGCCCATCACCCCTCTCCAACAAGCTG
CTCCCGGAGTGGGTCCCCCCTTCAGCCAGGCCCCAGCTCCCCAACTACCCCCAGGACCCCCTGGCGCCCCCAAGCCACCACCTGCTTCCC
AGCCCAGTCTGGTCTCCACTGTGGCCCCTGGCTCCGGCCTGGCTCCCACGGCACAGCCCGGGGCACCGTCCATGGCAGGCACTGTGGCCC
CAGGAGGGGTGAGCGGCCCTTCCCCAGCCCAGCTGGGAGCCCCAGCCCTCGGTGGGCAGCAGTCAGTCTCCAATAAGCTTCTGGCCTGGA
GCGGGGTCCTGGAGTGGCAAGAGAAACCCAAACCTGCCTCAGTGGATGCCAACACCAAGCTGACGCGGTCACTGCCCTGCCAGGTCTACG
TGAATCATGGCGAGAACCTGAAGACGGAGCAGTGGCCCCAGAAGCTGATCATGCAGCTCATCCCCCAGCAGCTGCTGACCACCCTGGGCC
CTTTGTTCCGGAACTCAAGGATGGTCCAGTTCCATTTCACCAACAAGGACCTGGAGTCTCTCAAAGGCCTCTACCGCATCATGGGCAACG
GCTTCGCCTATGGCATTGTGTGGAAGGCAGTGGACCGGAGGACTGGTGAGGTCGTGGCCATCAAGAAAATCTTTGATGCTTTTAGGGATA
AGACAGATGCCCAGAGAACATTCCGGGAAATCACGCTCCTCCAGGAGTTTGGGGACCATCCCAACATCATCAGCCTCCTTGACGTGATCC
GGGCAGAGAACGACAGGGACATTTACCTGGTGTTTGAGTTTATGGGTTGCCCCCCCAGCCCCCCACCCCCGACTGCAGTGCGCACCCTCT
CTGCAGACACTGACCTGAACGCAGTCATCCGGAAGGGCGGCCTGCTGCAGGACGTCCACGTGCGCTCCATCTTCTACCAGCTCCTGCGGG
CCACCCGGTTCCTCCACTCGGGGCACGTTGTGCACCGGGACCAGAAGCCGTCCAATGTGCTCCTGGATGCCAACTGCACAGTGAAGCTGT
GTGACTTTGGCCTGGCCCGCTCCCTGGGCGACCTCCCCGAGGGGCCTGAGGACCAGGCCGTGACAGAGTACGTGGCCACACGCTGGTACC
GAGCACCGGAGGTGCTGCTCTCTTCGCACCGATACACCCTTGGGGTGGACATGTGGAGTCTGGGCTGTATCCTGGGGGAGATGCTGCGGG
GGAGACCCCTGTTCCCCGGCACGTCCACCCTCCACCAGCTGGAGCTGATCCTGGAGACCATCCCACCGCCATCTGAGGAGGACCTCCTGG

>52733_52733_2_MED25-MAPK15_MED25_chr19_50335672_ENST00000312865_MAPK15_chr8_144799864_ENST00000395107_length(amino acids)=750AA_BP=260
MVPGSEGPARAGSVVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSS
AYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTENLVQQIGERGIHF
SIVSPRKLPALRLLFEKAAPPALLEPLQPPTDVSQDPRHMVLVRGLVLPVGGGSAPGPLQSKQPVPLPPAAPSGATLSAAPQQPLPPVPP
QYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTA
QPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIM
QLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFG
DHPNIISLLDVIRAENDRDIYLVFEFMGCPPSPPPPTAVRTLSADTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFLHSGHVVHRDQKPS
NVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYRAPEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELIL

--------------------------------------------------------------
>52733_52733_3_MED25-MAPK15_MED25_chr19_50335672_ENST00000312865_MAPK15_chr8_144799864_ENST00000395108_length(transcript)=2234nt_BP=1535nt
ATTCCGCGGCGTCGGCTGCGGCTGCAGTGGTGGTGGCGGGTACCGCACGGGGTATGGTCCCCGGGTCCGAGGGCCCGGCCCGCGCCGGGA
GCGTGGTGGCCGACGTGGTGTTTGTGATTGAGGGTACGGCCAACCTGGGACCCTACTTCGAGGGGCTCCGCAAGCACTACCTGCTCCCGG
CCATCGAGTATTTTAATGGTGGTCCTCCTGCTGAGACGGACTTCGGGGGAGACTATGGGGGGACCCAGTACAGCCTCGTGGTGTTCAACA
CAGTGGACTGCGCTCCCGAGTCCTACGTACAATGTCACGCTCCCACCAGCAGCGCCTATGAGTTTGTCACCTGGCTCGATGGCATTAAGT
TCATGGGCGGGGGTGGTGAGAGCTGCAGCCTCATCGCGGAAGGACTCAGCACAGCCTTGCAGCTGTTTGATGACTTCAAGAAGATGCGCG
AGCAGATTGGCCAGACGCACCGGGTCTGCCTCCTCATCTGCAACTCACCCCCATACTTGTTGCCTGCTGTTGAGAGCACCACGTACTCTG
GATGCACAACTGAGAATCTTGTGCAGCAGATTGGGGAGCGGGGGATCCACTTCTCCATTGTGTCTCCCCGGAAGCTGCCTGCGCTTCGGC
TTCTGTTTGAGAAGGCAGCCCCCCCGGCCTTGCTGGAGCCGCTGCAGCCTCCGACAGATGTGAGCCAGGACCCGAGGCACATGGTGCTGG
TTCGGGGACTCGTGCTGCCTGTTGGGGGTGGCTCAGCCCCAGGCCCCCTCCAGTCAAAGCAGCCAGTCCCCCTGCCTCCCGCCGCACCCT
CAGGTGCCACTCTCTCAGCAGCCCCCCAGCAGCCTCTGCCCCCCGTCCCCCCGCAGTACCAGGTTCCCGGGAACCTGAGTGCAGCTCAGG
TGGCCGCGCAGAATGCAGTGGAGGCTGCCAAGAACCAGAAGGCTGGGCTGGGCCCTCGCTTCTCGCCCATCACCCCTCTCCAACAAGCTG
CTCCCGGAGTGGGTCCCCCCTTCAGCCAGGCCCCAGCTCCCCAACTACCCCCAGGACCCCCTGGCGCCCCCAAGCCACCACCTGCTTCCC
AGCCCAGTCTGGTCTCCACTGTGGCCCCTGGCTCCGGCCTGGCTCCCACGGCACAGCCCGGGGCACCGTCCATGGCAGGCACTGTGGCCC
CAGGAGGGGTGAGCGGCCCTTCCCCAGCCCAGCTGGGAGCCCCAGCCCTCGGTGGGCAGCAGTCAGTCTCCAATAAGCTTCTGGCCTGGA
GCGGGGTCCTGGAGTGGCAAGAGAAACCCAAACCTGCCTCAGTGGATGCCAACACCAAGCTGACGCGGTCACTGCCCTGCCAGGTCTACG
TGAATCATGGCGAGAACCTGAAGACGGAGCAGTGGCCCCAGAAGCTGATCATGCAGCTCATCCCCCAGCAGCTGCTGACCACCCTGGGCC
CTTTGTTCCGGAACTCAAGGATGGTCCAGTTCCATTTCACCAACAAGGACCTGGAGTCTCTCAAAGGCCTCTACCGCATCATGGGCAACG
GCTTCGCCTATGGCATTGTGTGGAAGGCAGTGGACCGGAGGACTGGTGAGGTCGTGGCCATCAAGAAAATCTTTGATGCTTTTAGGGATA
AGACAGATGCCCAGAGAACATTCCGGGAAATCACGCTCCTCCAGGAGTTTGGGGACCATCCCAACATCATCAGCCTCCTTGACGTGATCC
GGGCAGAGAACGACAGGGACATTTACCTGGTGTTTGAGTTTATGGACACTGACCTGAACGCAGTCATCCGGAAGGGCGGCCTGCTGCAGG
ACGTCCACGTGCGCTCCATCTTCTACCAGCTCCTGCGGGCCACCCGGTTCCTCCACTCGGGGCACGTTGTGCACCGGGACCAGAAGCCGT
CCAATGTGCTCCTGGATGCCAACTGCACAGTGAAGCTGTGTGACTTTGGCCTGGCCCGCTCCCTGGGCGACCTCCCCGAGGGGCCTGAGG
ACCAGGCCGTGACAGAGTACGTGGCCACACGCTGGTACCGAGCACCGGAGGTGCTGCTCTCTTCGCACCGATACACCCTTGGGGTGGACA
TGTGGAGTCTGGGCTGTATCCTGGGGGAGATGCTGCGGGGGAGACCCCTGTTCCCCGGCACGTCCACCCTCCACCAGCTGGAGCTGATCC

>52733_52733_3_MED25-MAPK15_MED25_chr19_50335672_ENST00000312865_MAPK15_chr8_144799864_ENST00000395108_length(amino acids)=727AA_BP=260
MVPGSEGPARAGSVVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSS
AYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTENLVQQIGERGIHF
SIVSPRKLPALRLLFEKAAPPALLEPLQPPTDVSQDPRHMVLVRGLVLPVGGGSAPGPLQSKQPVPLPPAAPSGATLSAAPQQPLPPVPP
QYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTA
QPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIM
QLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFG
DHPNIISLLDVIRAENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGL
ARSLGDLPEGPEDQAVTEYVATRWYRAPEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEGAQTACRS

--------------------------------------------------------------
>52733_52733_4_MED25-MAPK15_MED25_chr19_50335672_ENST00000538643_MAPK15_chr8_144799864_ENST00000338033_length(transcript)=2619nt_BP=843nt
ATGGTCCCCGGGTCCGAGGGCCCGGCCCGCGCCGGGAGCGTGGTGGCCGACGTGGTGTTTGTGATTGAGGGTACGGCCAACCTGGGACCC
TACTTCGAGGGGCTCCGCAAGCACTACCTGCTCCCGGCCATCGAGTATTTTAATGGTGGTCCTCCTGCTGAGACGGACTTCGGGGGAGAC
GTTCCCGGGAACCTGAGTGCAGCTCAGGTGGCCGCGCAGAATGCAGTGGAGGCTGCCAAGAACCAGAAGGCTGGGCTGGGCCCTCGCTTC
TCGCCCATCACCCCTCTCCAACAAGCTGCTCCCGGAGTGGGTCCCCCCTTCAGCCAGGCCCCAGCTCCCCAACTACCCCCAGGACCCCCT
GGCGCCCCCAAGCCACCACCTGCTTCCCAGCCCAGTCTGGTCTCCACTGTGGCCCCTGGCTCCGGCCTGGCTCCCACGGCACAGCCCGGG
GCACCGTCCATGGCAGGCACTGTGGCCCCAGGAGGGGTGAGCGGCCCTTCCCCAGCCCAGCTGGGAGCCCCAGCCCTCGGTGGGCAGCAG
TCAGTCTCCAATAAGCTTCTGGCCTGGAGCGGGGTCCTGGAGTGGCAAGAGAAACCCAAACCTGCCTCAGTGGATGCCAACACCAAGCTG
ACGCGGTCACTGCCCTGCCAGGTCTACGTGAATCATGGCGAGAACCTGAAGACGGAGCAGTGGCCCCAGAAGCTGATCATGCAGCTCATC
CCCCAGCAGCTGCTGACCACCCTGGGCCCTTTGTTCCGGAACTCAAGGATGGTCCAGTTCCATTTCACCAACAAGGACCTGGAGTCTCTC
AAAGGCCTCTACCGCATCATGGGCAACGGCTTCGCCTATGGCATTGTGTGGAAGGCAGTGGACCGGAGGACTGGTGAGGTCGTGGCCATC
AAGAAAATCTTTGATGCTTTTAGGGATAAGACAGATGCCCAGAGAACATTCCGGGAAATCACGCTCCTCCAGGAGTTTGGGGACCATCCC
AACATCATCAGCCTCCTTGACGTGATCCGGGCAGAGAACGACAGGGACATTTACCTGGTGTTTGAGTTTATGGACACTGACCTGAACGCA
GTCATCCGGAAGGGCGGCCTGCTGCAGGACGTCCACGTGCGCTCCATCTTCTACCAGCTCCTGCGGGCCACCCGGTTCCTCCACTCGGGG
CACGTTGTGCACCGGGACCAGAAGCCGTCCAATGTGCTCCTGGATGCCAACTGCACAGTGAAGCTGTGTGACTTTGGCCTGGCCCGCTCC
CTGGGCGACCTCCCCGAGGGGCCTGAGGACCAGGCCGTGACAGAGTACGTGGCCACACGCTGGTACCGAGCACCGGAGGTGCTGCTCTCT
TCGCACCGATACACCCTTGGGGTGGACATGTGGAGTCTGGGCTGTATCCTGGGGGAGATGCTGCGGGGGAGACCCCTGTTCCCCGGCACG
TCCACCCTCCACCAGCTGGAGCTGATCCTGGAGACCATCCCACCGCCATCTGAGGAGGACCTCCTGGCTCTCGGCTCAGGCTGCCGTGCC
TCTGTGCTGCACCAGCTGGGGTCCCGGCCACGACAGACGCTGGATGCCCTCCTACCGCCAGACACCTCCCCAGAGGCCTTGGACCTCCTT
AGGCGACTCCTGGTGTTCGCCCCGGACAAGCGGTTAAGCGCGACCCAGGCACTGCAGCACCCCTACGTGCAGAGGTTCCACTGCCCCAGC
GACGAGTGGGCACGAGAGGCAGATGTGCGGCCCCGGGCACACGAAGGGGTCCAGCTCTCTGTGCCTGAGTACCGCAGCCGCGTCTATCAG
ATGATCCTGGAGTGTGGAGGCAGCAGCGGCACCTCGAGAGAGAAGGGCCCGGAGGGTGTCTCCCCAAGCCAGGCACACCTGCACAAACCC
AGAGCCGACCCTCAGCTGCCTTCTAGGACACCTGTGCAGGGTCCCAGACCCAGGCCCCAGAGCAGCCCAGGCCATGACCCTGCCGAGCAC
GAGTCCCCCCGTGCAGCCAAGAACGTTCCCAGGCAGAACTCCGCTCCCCTGCTCCAAACTGCTCTCCTAGGGAATGGGGAAAGGCCCCCT
GGGGCGAAGGAAGCGCCCCCCTTGACACTCTCGCTGGTGAAGCCAAGCGGGAGGGGAGCTGCGCCCTCCCTGACCTCCCAGGCTGCGGCT
CAGGTGGCCAACCAGGCCCTGATCCGGGGTGACTGGAACCGGGGCGGTGGGGTGAGGGTGGCCAGCGTACAACAGGTCCCTCCCCGGCTT
CCTCCGGAGGCCCGGCCCGGCCGGAGGATGTTCAGCACCTCTGCCTTGCAGGGTGCCCAGGGGGGTGCCAGGGCTTTGCTTGGAGGCTAC
TCCCAAGCCTACGGGACTGTCTGCCACTCGGCACTGGGCCACCTGCCCCTGCTGGAGGGGCACCATGTGTGAGCCGCCCTACTCCCTTCA
CCTGGCCCTCTGTTCCTGCCCCAGCCCCTTCCCCAGACCCCTCTCCAGTCTCCTGCACCCCTTAGCCCTCCCTGCTTTGCCTGGCCCGTT
GAAGTTCCAGGGAGCTTGCCCGGGTCTCCTCGGGGGAGCAGATGAGGGCCCTGCCCCCGCCCCACTGACTTCCTCCAATAAAGTCATGTC

>52733_52733_4_MED25-MAPK15_MED25_chr19_50335672_ENST00000538643_MAPK15_chr8_144799864_ENST00000338033_length(amino acids)=803AA_BP=281
MVPGSEGPARAGSVVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDVPGNLSAAQVAAQNAVEAAKNQKAGLGPRF
SPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQ
SVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESL
KGLYRIMGNGFAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHPNIISLLDVIRAENDRDIYLVFEFMDTDLNA
VIRKGGLLQDVHVRSIFYQLLRATRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYRAPEVLLS
SHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLALGSGCRASVLHQLGSRPRQTLDALLPPDTSPEALDLL
RRLLVFAPDKRLSATQALQHPYVQRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSRVYQMILECGGSSGTSREKGPEGVSPSQAHLHKP
RADPQLPSRTPVQGPRPRPQSSPGHDPAEHESPRAAKNVPRQNSAPLLQTALLGNGERPPGAKEAPPLTLSLVKPSGRGAAPSLTSQAAA

--------------------------------------------------------------
>52733_52733_5_MED25-MAPK15_MED25_chr19_50335672_ENST00000538643_MAPK15_chr8_144799864_ENST00000395107_length(transcript)=1611nt_BP=843nt
ATGGTCCCCGGGTCCGAGGGCCCGGCCCGCGCCGGGAGCGTGGTGGCCGACGTGGTGTTTGTGATTGAGGGTACGGCCAACCTGGGACCC
TACTTCGAGGGGCTCCGCAAGCACTACCTGCTCCCGGCCATCGAGTATTTTAATGGTGGTCCTCCTGCTGAGACGGACTTCGGGGGAGAC
GTTCCCGGGAACCTGAGTGCAGCTCAGGTGGCCGCGCAGAATGCAGTGGAGGCTGCCAAGAACCAGAAGGCTGGGCTGGGCCCTCGCTTC
TCGCCCATCACCCCTCTCCAACAAGCTGCTCCCGGAGTGGGTCCCCCCTTCAGCCAGGCCCCAGCTCCCCAACTACCCCCAGGACCCCCT
GGCGCCCCCAAGCCACCACCTGCTTCCCAGCCCAGTCTGGTCTCCACTGTGGCCCCTGGCTCCGGCCTGGCTCCCACGGCACAGCCCGGG
GCACCGTCCATGGCAGGCACTGTGGCCCCAGGAGGGGTGAGCGGCCCTTCCCCAGCCCAGCTGGGAGCCCCAGCCCTCGGTGGGCAGCAG
TCAGTCTCCAATAAGCTTCTGGCCTGGAGCGGGGTCCTGGAGTGGCAAGAGAAACCCAAACCTGCCTCAGTGGATGCCAACACCAAGCTG
ACGCGGTCACTGCCCTGCCAGGTCTACGTGAATCATGGCGAGAACCTGAAGACGGAGCAGTGGCCCCAGAAGCTGATCATGCAGCTCATC
CCCCAGCAGCTGCTGACCACCCTGGGCCCTTTGTTCCGGAACTCAAGGATGGTCCAGTTCCATTTCACCAACAAGGACCTGGAGTCTCTC
AAAGGCCTCTACCGCATCATGGGCAACGGCTTCGCCTATGGCATTGTGTGGAAGGCAGTGGACCGGAGGACTGGTGAGGTCGTGGCCATC
AAGAAAATCTTTGATGCTTTTAGGGATAAGACAGATGCCCAGAGAACATTCCGGGAAATCACGCTCCTCCAGGAGTTTGGGGACCATCCC
AACATCATCAGCCTCCTTGACGTGATCCGGGCAGAGAACGACAGGGACATTTACCTGGTGTTTGAGTTTATGGGTTGCCCCCCCAGCCCC
CCACCCCCGACTGCAGTGCGCACCCTCTCTGCAGACACTGACCTGAACGCAGTCATCCGGAAGGGCGGCCTGCTGCAGGACGTCCACGTG
CGCTCCATCTTCTACCAGCTCCTGCGGGCCACCCGGTTCCTCCACTCGGGGCACGTTGTGCACCGGGACCAGAAGCCGTCCAATGTGCTC
CTGGATGCCAACTGCACAGTGAAGCTGTGTGACTTTGGCCTGGCCCGCTCCCTGGGCGACCTCCCCGAGGGGCCTGAGGACCAGGCCGTG
ACAGAGTACGTGGCCACACGCTGGTACCGAGCACCGGAGGTGCTGCTCTCTTCGCACCGATACACCCTTGGGGTGGACATGTGGAGTCTG
GGCTGTATCCTGGGGGAGATGCTGCGGGGGAGACCCCTGTTCCCCGGCACGTCCACCCTCCACCAGCTGGAGCTGATCCTGGAGACCATC

>52733_52733_5_MED25-MAPK15_MED25_chr19_50335672_ENST00000538643_MAPK15_chr8_144799864_ENST00000395107_length(amino acids)=536AA_BP=281
MVPGSEGPARAGSVVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDVPGNLSAAQVAAQNAVEAAKNQKAGLGPRF
SPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQ
SVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESL
KGLYRIMGNGFAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHPNIISLLDVIRAENDRDIYLVFEFMGCPPSP
PPPTAVRTLSADTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAV

--------------------------------------------------------------
>52733_52733_6_MED25-MAPK15_MED25_chr19_50335672_ENST00000538643_MAPK15_chr8_144799864_ENST00000395108_length(transcript)=1542nt_BP=843nt
ATGGTCCCCGGGTCCGAGGGCCCGGCCCGCGCCGGGAGCGTGGTGGCCGACGTGGTGTTTGTGATTGAGGGTACGGCCAACCTGGGACCC
TACTTCGAGGGGCTCCGCAAGCACTACCTGCTCCCGGCCATCGAGTATTTTAATGGTGGTCCTCCTGCTGAGACGGACTTCGGGGGAGAC
GTTCCCGGGAACCTGAGTGCAGCTCAGGTGGCCGCGCAGAATGCAGTGGAGGCTGCCAAGAACCAGAAGGCTGGGCTGGGCCCTCGCTTC
TCGCCCATCACCCCTCTCCAACAAGCTGCTCCCGGAGTGGGTCCCCCCTTCAGCCAGGCCCCAGCTCCCCAACTACCCCCAGGACCCCCT
GGCGCCCCCAAGCCACCACCTGCTTCCCAGCCCAGTCTGGTCTCCACTGTGGCCCCTGGCTCCGGCCTGGCTCCCACGGCACAGCCCGGG
GCACCGTCCATGGCAGGCACTGTGGCCCCAGGAGGGGTGAGCGGCCCTTCCCCAGCCCAGCTGGGAGCCCCAGCCCTCGGTGGGCAGCAG
TCAGTCTCCAATAAGCTTCTGGCCTGGAGCGGGGTCCTGGAGTGGCAAGAGAAACCCAAACCTGCCTCAGTGGATGCCAACACCAAGCTG
ACGCGGTCACTGCCCTGCCAGGTCTACGTGAATCATGGCGAGAACCTGAAGACGGAGCAGTGGCCCCAGAAGCTGATCATGCAGCTCATC
CCCCAGCAGCTGCTGACCACCCTGGGCCCTTTGTTCCGGAACTCAAGGATGGTCCAGTTCCATTTCACCAACAAGGACCTGGAGTCTCTC
AAAGGCCTCTACCGCATCATGGGCAACGGCTTCGCCTATGGCATTGTGTGGAAGGCAGTGGACCGGAGGACTGGTGAGGTCGTGGCCATC
AAGAAAATCTTTGATGCTTTTAGGGATAAGACAGATGCCCAGAGAACATTCCGGGAAATCACGCTCCTCCAGGAGTTTGGGGACCATCCC
AACATCATCAGCCTCCTTGACGTGATCCGGGCAGAGAACGACAGGGACATTTACCTGGTGTTTGAGTTTATGGACACTGACCTGAACGCA
GTCATCCGGAAGGGCGGCCTGCTGCAGGACGTCCACGTGCGCTCCATCTTCTACCAGCTCCTGCGGGCCACCCGGTTCCTCCACTCGGGG
CACGTTGTGCACCGGGACCAGAAGCCGTCCAATGTGCTCCTGGATGCCAACTGCACAGTGAAGCTGTGTGACTTTGGCCTGGCCCGCTCC
CTGGGCGACCTCCCCGAGGGGCCTGAGGACCAGGCCGTGACAGAGTACGTGGCCACACGCTGGTACCGAGCACCGGAGGTGCTGCTCTCT
TCGCACCGATACACCCTTGGGGTGGACATGTGGAGTCTGGGCTGTATCCTGGGGGAGATGCTGCGGGGGAGACCCCTGTTCCCCGGCACG
TCCACCCTCCACCAGCTGGAGCTGATCCTGGAGACCATCCCACCGCCATCTGAGGAGGGGGCCCAGACTGCCTGCAGGTCAGGCACAGGG

>52733_52733_6_MED25-MAPK15_MED25_chr19_50335672_ENST00000538643_MAPK15_chr8_144799864_ENST00000395108_length(amino acids)=513AA_BP=281
MVPGSEGPARAGSVVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDVPGNLSAAQVAAQNAVEAAKNQKAGLGPRF
SPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQ
SVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESL
KGLYRIMGNGFAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHPNIISLLDVIRAENDRDIYLVFEFMDTDLNA
VIRKGGLLQDVHVRSIFYQLLRATRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYRAPEVLLS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MED25-MAPK15


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneMED25chr19:50335672chr8:144799864ENST00000312865+13181_226494.0748.0the Mediator complex
HgeneMED25chr19:50335672chr8:144799864ENST00000538643+8131_226281.0535.0the Mediator complex


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMED25chr19:50335672chr8:144799864ENST00000312865+1318395_545494.0748.0CREBBP
HgeneMED25chr19:50335672chr8:144799864ENST00000538643+813395_545281.0535.0CREBBP
HgeneMED25chr19:50335672chr8:144799864ENST00000312865+1318564_653494.0748.0RARA
HgeneMED25chr19:50335672chr8:144799864ENST00000312865+1318640_707494.0748.0RARA
HgeneMED25chr19:50335672chr8:144799864ENST00000538643+813564_653281.0535.0RARA
HgeneMED25chr19:50335672chr8:144799864ENST00000538643+813640_707281.0535.0RARA
HgeneMED25chr19:50335672chr8:144799864ENST00000312865+1318389_543494.0748.0VP16
HgeneMED25chr19:50335672chr8:144799864ENST00000538643+813389_543281.0535.0VP16


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MED25-MAPK15


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MED25-MAPK15


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource