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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:MED26-PLCB1 (FusionGDB2 ID:52748) |
Fusion Gene Summary for MED26-PLCB1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MED26-PLCB1 | Fusion gene ID: 52748 | Hgene | Tgene | Gene symbol | MED26 | PLCB1 | Gene ID | 9441 | 23236 |
| Gene name | mediator complex subunit 26 | phospholipase C beta 1 | |
| Synonyms | CRSP7|CRSP70 | EIEE12|PI-PLC|PLC-154|PLC-I|PLC-beta-1|PLC154|PLCB1A|PLCB1B | |
| Cytomap | 19p13.11 | 20p12.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mediator of RNA polymerase II transcription subunit 26ARC70CRSP complex subunit 7activator-recruited cofactor 70 kDa componentcofactor required for Sp1 transcriptional activation subunit 7cofactor required for Sp1 transcriptional activation, subunit | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-11-phosphatidyl-D-myo-inositol-4,5-bisphosphateinositoltrisphosphohydrolasemonophosphatidylinositol phosphodiesterasephosphoinositidase Cphosphoinositide phospholipase Cphospholipase C, | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | O95402 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000263390, | ENST00000494924, ENST00000338037, ENST00000378637, ENST00000378641, | |
| Fusion gene scores | * DoF score | 16 X 4 X 12=768 | 13 X 13 X 5=845 |
| # samples | 18 | 14 | |
| ** MAII score | log2(18/768*10)=-2.09310940439148 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(14/845*10)=-2.59352451422458 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MED26 [Title/Abstract] AND PLCB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | MED26(16738683)-PLCB1(8608941), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MED26 | GO:0006357 | regulation of transcription by RNA polymerase II | 15989967 |
| Tgene | PLCB1 | GO:0035722 | interleukin-12-mediated signaling pathway | 11743656 |
| Tgene | PLCB1 | GO:0035723 | interleukin-15-mediated signaling pathway | 11743656 |
| Tgene | PLCB1 | GO:0046330 | positive regulation of JNK cascade | 9500449 |
| Tgene | PLCB1 | GO:0070498 | interleukin-1-mediated signaling pathway | 8872139 |
| Fusion gene breakpoints across MED26 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across PLCB1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | SARC | TCGA-3B-A9HI-01A | MED26 | chr19 | 16738683 | - | PLCB1 | chr20 | 8608941 | + |
| ChimerDB4 | SARC | TCGA-QQ-A5VB-01A | MED26 | chr19 | 16738683 | - | PLCB1 | chr20 | 8608941 | + |
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Fusion Gene ORF analysis for MED26-PLCB1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000263390 | ENST00000494924 | MED26 | chr19 | 16738683 | - | PLCB1 | chr20 | 8608941 | + |
| In-frame | ENST00000263390 | ENST00000338037 | MED26 | chr19 | 16738683 | - | PLCB1 | chr20 | 8608941 | + |
| In-frame | ENST00000263390 | ENST00000378637 | MED26 | chr19 | 16738683 | - | PLCB1 | chr20 | 8608941 | + |
| In-frame | ENST00000263390 | ENST00000378641 | MED26 | chr19 | 16738683 | - | PLCB1 | chr20 | 8608941 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000263390 | MED26 | chr19 | 16738683 | - | ENST00000378641 | PLCB1 | chr20 | 8608941 | + | 6909 | 335 | 263 | 3610 | 1115 |
| ENST00000263390 | MED26 | chr19 | 16738683 | - | ENST00000338037 | PLCB1 | chr20 | 8608941 | + | 6791 | 335 | 263 | 3739 | 1158 |
| ENST00000263390 | MED26 | chr19 | 16738683 | - | ENST00000378637 | PLCB1 | chr20 | 8608941 | + | 3940 | 335 | 263 | 3610 | 1115 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000263390 | ENST00000378641 | MED26 | chr19 | 16738683 | - | PLCB1 | chr20 | 8608941 | + | 0.000126372 | 0.99987364 |
| ENST00000263390 | ENST00000338037 | MED26 | chr19 | 16738683 | - | PLCB1 | chr20 | 8608941 | + | 0.000178242 | 0.99982184 |
| ENST00000263390 | ENST00000378637 | MED26 | chr19 | 16738683 | - | PLCB1 | chr20 | 8608941 | + | 0.000912816 | 0.9990872 |
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Fusion Genomic Features for MED26-PLCB1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for MED26-PLCB1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:16738683/chr20:8608941) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MED26 | . |
| FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | PLCB1 | chr19:16738683 | chr20:8608941 | ENST00000338037 | 2 | 32 | 316_467 | 82 | 1217.0 | Domain | PI-PLC X-box | |
| Tgene | PLCB1 | chr19:16738683 | chr20:8608941 | ENST00000338037 | 2 | 32 | 540_656 | 82 | 1217.0 | Domain | PI-PLC Y-box | |
| Tgene | PLCB1 | chr19:16738683 | chr20:8608941 | ENST00000338037 | 2 | 32 | 656_786 | 82 | 1217.0 | Domain | C2 | |
| Tgene | PLCB1 | chr19:16738683 | chr20:8608941 | ENST00000378637 | 2 | 32 | 316_467 | 82 | 1174.0 | Domain | PI-PLC X-box | |
| Tgene | PLCB1 | chr19:16738683 | chr20:8608941 | ENST00000378637 | 2 | 32 | 540_656 | 82 | 1174.0 | Domain | PI-PLC Y-box | |
| Tgene | PLCB1 | chr19:16738683 | chr20:8608941 | ENST00000378637 | 2 | 32 | 656_786 | 82 | 1174.0 | Domain | C2 | |
| Tgene | PLCB1 | chr19:16738683 | chr20:8608941 | ENST00000378641 | 2 | 33 | 316_467 | 82 | 2075.6666666666665 | Domain | PI-PLC X-box | |
| Tgene | PLCB1 | chr19:16738683 | chr20:8608941 | ENST00000378641 | 2 | 33 | 540_656 | 82 | 2075.6666666666665 | Domain | PI-PLC Y-box | |
| Tgene | PLCB1 | chr19:16738683 | chr20:8608941 | ENST00000378641 | 2 | 33 | 656_786 | 82 | 2075.6666666666665 | Domain | C2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MED26 | chr19:16738683 | chr20:8608941 | ENST00000263390 | - | 1 | 3 | 228_325 | 24 | 601.0 | Compositional bias | Note=Pro-rich |
| Hgene | MED26 | chr19:16738683 | chr20:8608941 | ENST00000263390 | - | 1 | 3 | 10_87 | 24 | 601.0 | Domain | TFIIS N-terminal |
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Fusion Gene Sequence for MED26-PLCB1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >52748_52748_1_MED26-PLCB1_MED26_chr19_16738683_ENST00000263390_PLCB1_chr20_8608941_ENST00000338037_length(transcript)=6791nt_BP=335nt TCACTGGAGTTTGGTTCTCGAGGCGGCGGCAGCGAGCGGCGGCGGCTCCGGCGGCTCCTCCTCCTCCTTTGGTGGCGGCGGCGGCCCGGG ACCGAGACCCGGCCCCGGCTCCCCTCTCCGCCACCCCGCGCGCCCCCAACCCCCCGGCGCCGCGGGGAACATGCGGCTCCGGCTCCCGGA GGCCGGCGAGTGAGTGACCCCCGTCCCCCGCCTCAGCCCGCCCGCCCGCTGGCCCGGCCGCAACCCCCCGCCTCGCCCAGGCAATGACAG CGGCTCCGGCGTCTCCGCAGCAGATCAGGGACCGGCTGCTGCAGGCCATCGACCCCCAGAGCAACGACCCCAAATTACGTGAACTTTTGG ATGTGGGGAACATCGGGCGCCTGGAGCAGCGCATGATCACAGTGGTGTATGGGCCTGACCTCGTGAACATCTCCCATTTGAATCTCGTGG CTTTCCAAGAAGAAGTGGCCAAGGAATGGACAAATGAGGTTTTCAGTTTGGCAACAAACCTGCTGGCCCAAAACATGTCCAGGGATGCAT TTCTGGAAAAAGCCTATACTAAACTTAAGCTGCAAGTCACTCCAGAAGGGCGTATTCCTCTCAAAAACATATATCGCTTGTTTTCAGCAG ATCGGAAGCGAGTTGAAACTGCTTTAGAGGCTTGTAGTCTTCCATCTTCAAGGAATGATTCAATACCTCAAGAAGATTTCACTCCAGAAG TGTACAGAGTTTTCCTCAACAACCTTTGCCCTCGACCTGAAATTGATAACATCTTTTCAGAATTTGGTGCAAAAAGCAAACCATATCTTA CCGTTGATCAGATGATGGATTTTATCAACCTTAAGCAGCGAGATCCTCGGCTTAATGAAATACTTTATCCACCTCTAAAACAAGAGCAAG TCCAAGTATTGATTGAGAAGTATGAACCCAACAACAGCCTCGCCAGAAAAGGACAAATATCAGTGGATGGGTTCATGCGCTATCTGAGTG GAGAAGAAAACGGAGTCGTTTCACCTGAGAAACTGGATTTGAATGAAGACATGTCTCAGCCCCTTTCTCACTATTTCATTAATTCCTCGC ACAACACCTACCTCACAGCTGGCCAACTGGCTGGAAACTCCTCTGTTGAGATGTATCGCCAAGTGCTCCTGTCTGGTTGTCGCTGTGTGG AGCTGGACTGCTGGAAGGGACGGACTGCAGAAGAGGAACCTGTCATCACCCATGGCTTCACCATGACAACTGAAATATCTTTCAAGGAAG TGATAGAAGCAATTGCGGAGTGTGCATTTAAGACTTCACCTTTTCCAATTCTCCTTTCGTTTGAGAACCATGTGGATTCCCCAAAGCAGC AAGCCAAGATGGCGGAGTACTGCCGACTGATCTTTGGGGATGCCCTTCTCATGGAGCCCCTGGAAAAATATCCACTGGAATCTGGAGTTC CTCTTCCAAGCCCTATGGATTTAATGTATAAAATTTTGGTGAAAAATAAGAAGAAATCACACAAGTCATCAGAAGGAAGCGGCAAAAAGA AGCTCTCAGAACAAGCCTCCAACACCTACAGTGACTCCTCCAGCATGTTCGAGCCCTCATCCCCAGGAGCCGGAGAAGCTGATACGGAAA GTGACGACGACGATGATGATGATGACTGTAAAAAATCTTCAATGGATGAGGGGACTGCTGGAAGTGAGGCTATGGCCACAGAAGAAATGT CTAATCTGGTGAACTATATTCAGCCAGTCAAGTTTGAGTCATTTGAAATTTCAAAAAAAAGAAATAAAAGTTTTGAAATGTCTTCCTTCG TGGAAACCAAAGGACTTGAACAACTCACCAAGTCTCCAGTGGAATTTGTAGAATATAACAAAATGCAGCTTAGCAGGATATATCCAAAAG GAACACGTGTGGATTCATCCAACTATATGCCTCAGCTCTTCTGGAATGCAGGTTGTCAGATGGTGGCACTTAATTTCCAGACAATGGACC TGGCTATGCAAATAAATATGGGGATGTATGAATACAACGGGAAGAGTGGCTACAGATTGAAGCCAGAGTTCATGAGGAGGCCTGACAAGC ATTTTGATCCATTTACTGAAGGCATCGTAGATGGGATAGTGGCAAACACTTTGTCTGTTAAGATTATTTCAGGTCAGTTTCTTTCTGATA AGAAAGTTGGGACTTACGTGGAAGTAGATATGTTTGGTTTGCCTGTGGATACAAGGAGGAAGGCATTTAAGACCAAAACATCCCAAGGAA ATGCTGTGAATCCTGTCTGGGAAGAAGAACCTATTGTGTTCAAAAAGGTGGTTCTTCCTACTCTGGCCTGTTTGAGAATAGCAGTTTATG AAGAAGGAGGTAAATTCATTGGCCACCGTATCTTGCCAGTGCAAGCCATTCGGCCAGGCTATCACTATATCTGTCTAAGGAATGAAAGGA ACCAGCCTCTGACGCTGCCTGCTGTCTTTGTCTACATAGAAGTGAAAGACTATGTGCCAGACACATATGCAGATGTCATCGAAGCTTTAT CAAACCCAATCCGATATGTGAACCTGATGGAACAGAGAGCTAAGCAATTGGCTGCTTTGACACTGGAAGATGAAGAAGAAGTAAAGAAAG AGGCTGATCCTGGAGAAACACCATCAGAGGCTCCAAGTGAAGCGAGAACGACTCCAGCAGAAAATGGGGTGAATCACACTACAACCCTGA CACCCAAGCCACCCTCCCAGGCTCTCCACAGCCAGCCAGCTCCAGGTTCTGTAAAGGCACCTGCCAAAACAGAAGATCTTATTCAGAGTG TCTTAACAGAAGTGGAAGCACAGACCATCGAAGAACTAAAGCAACAGAAATCGTTTGTGAAACTTCAAAAGAAACACTACAAAGAAATGA AAGACCTGGTTAAGAGACACCACAAGAAAACCACTGACCTTATCAAAGAACACACTACCAAGTATAATGAAATTCAGAATGACTACTTGA GAAGGAGAGCCGCTTTGGAAAAGTCCGCCAAAAAGGACAGTAAGAAAAAATCGGAACCCAGCAGCCCTGATCATGGTTCATCAACGATTG AGCAAGACCTCGCTGCTCTGGATGCTGAAATGACCCAAAAGTTAATAGACTTGAAGGACAAACAACAGCAGCAGCTGCTTAATCTTCGGC AAGAACAGTATTATAGTGAAAAATACCAGAAGCGAGAACATATTAAACTGCTTATTCAAAAGTTGACGGATGTCGCAGAAGAGTGTCAGA ACAATCAGTTAAAGAAGCTCAAAGAAATCTGTGAGAAAGAAAAGAAAGAATTAAAGAAGAAAATGGATAAAAAGAGGCAGGAGAAGATAA CAGAAGCTAAATCCAAAGACAAAAGTCAGATGGAAGAGGAGAAGACAGAGATGATCCGGTCATATATCCAGGAAGTGGTGCAGTATATCA AGAGGCTAGAAGAAGCGCAAAGTAAACGGCAAGAAAAACTCGTAGAGAAACACAAGGAAATACGTCAGCAGATCCTGGATGAAAAGCCCA AGCTGCAGGTGGAGCTGGAGCAAGAATACCAAGACAAATTCAAAAGACTGCCCCTCGAGATTTTGGAATTCGTGCAGGAAGCCATGAAAG GAAAGATCAGTGAAGACAGCAATCACGGTTCTGCCCCTCTCTCCCTGTCCTCAGACCCTGGAAAAGTGAACCACAAGACTCCCTCCAGTG AGGAGCTGGGAGGAGACATCCCAGGAAAAGAATTTGATACTCCTCTGTGAATGCTCCTGCCAGGCCTTCAGAAATTGCATGGCCACTCCA GCGTCATCGGACTCTCTCTTATTACAAAGATCACTGCCCAGGACCATCTTCCCGAGAAGCATCCCTTAGCCTAAAATCCACACCAAAGGG AGAGTTCCAGAGGAATCCATGAAGAATTCCCATGCCCAGGCTCCATGTGTCATGTGGAAACCTCCACAGGTCTGCTAGTGAAGAATGCAT GTATGTGAGATTTTTGTTTTCTTTCCAATAGCAAATTCAAAGCAAGCAACTTGCAGGCTCCATGGAACTTTTAATGAAGGACAGTGTCTT CTTTGAAGAAAATCAAGCTCGTGTTTTTATTCGAAGCTCTGGTGTAAAATATTTCAAAGTCATAGAAATAGTTTGAGAAATGCATAGCAT TATTTAACACTATTGAACAGCCGACTTTGAGCATTGTTTCTTCTAACTGCCCCTCAACTACCATTATCTTCAAGTCAACATGCATATTAC ATTTTCATCCTTTGCTTTGCAAGCACTGGTGGCTTGCAGTTTGCTAATTTATTTATCATAGAGTCATCAATGTATTTGTTGCTGACATGG TTTTATTAGATACTGTAGTGATTCAAATAAGTTTTCTATTTGAAAAAAAAAATCACTTGATTGTATCCTTGCCCAGTGAAGCCATCCTAA GACTTAGCAATATGGATTGTACATTTGGCTGCATGAGCAAGTCGGCCGCACACTTCCAGACAGTGTGCTGTTTGAATTGACTATTTGCAC TCAAAGTCTGGGTATTCATTGGTTATTGGCCTGAAATGATCAAATAACTACAAATGATCTGTTGAATAAAAATAGTTGAGCTGATATATG TTAAGCAGATATTCAATCAGAATGAACAGGTTCCGGTGGTTATTTTGCCGTTTGACATTTTTTATGGTTCATTTATTTTTAATATAGAGA GGAAGATTGAATATTTATCTAGAGAATACAAAGACCCACATGTAAATGATAGGTATTATCTCCATGTATATATGTACCCACTTAGTCATG TAAGTGCATATACACATACACACACATGAGTGTAGACATGTGTTTATTAATTGACAATGACCCAAATCTCTTCCACAAGACTTAAAACCA AATTCAGGGACAAATGGATAGAGAAGAAAAGGGTCAAACATCGAGATTACATGGATGTTAAATTATATGGAGACGCTAAGAAATAATTGA TGGAGCCATTGATGCAAACCGAAGTAGATTTAGAACTTATATGAATTTGATTTATATTTTGCAAGATCAAAAATTAGATGTTAAGTATCA GATTTTAAGCTTGTTTTAATGGTCAAAAAATTAGGACAGAAATAATATGGACATTTATTAGTATCTTCCATAATTTTTAAGTCTGACACA TTTCTATTTTATTCTAACATAAAAAAACTTCCATTATATATTTACTAAGTATATTTAATTCACTTAACTCTGTCTTTATAAGTTCCTATT TTAGATGGAATAAGAGAAACAAATTATATCAAGGTAAAACTGATCAAAAGCATAATTGAAAGTTCTGAAAAAAGAAAAATAATAATATGT AGAAAAATGTAACTTAGAGAGTAACACATGAACATTGAAGTTAAAACCCAGAAGCCAGATGCTCACAGTTTTATTTTACTTTAAAATAAA CCTGTCTGACTGTAGCTTTGTGAAATATCTTAAAACGCAAAAACCAATTGTGTCCTGAAAATTGTTTCAAGAATTTAATATTTTTATGAA AATTATTTTATTTAACTTTAAGCAATAACTAGAGATTACAATTAAATTTTAATCAAAATGAAGGCTTAGTTCAAACATAAGGAAACAGTG TTTGATTAAAAAAAACACATCTAGTAAGACGTAAGGGGAAAATCACATCCTCTTTGGAGATGATTATATTTTGATCTGAAGGGTTTGGGG TGTTCATTAGACACTTAATAAAACTTAACTTCCAATGAAAAAGAAATCTTTTGTAAATCATTCTACTTTTGCACTTTGAAAGAAAGGCGT TAATCATAAAGAAGCAAGAATGGTCAAAATCGAATGCTGCATTTTTATAAACAAAATTACAGACTGTCTGAAATTGAAGAAGAATGAACT AATAATAGCATTCATAACCAAACACAATGATGATTATTGCAGAACATTGTATCACATTTTAGTCCAGAGATAGAATAAAGTTGAATAACC TTGACTTACACAAAACTGTTTTGGTAGTTGGATTTCATTATCTTAGTGAATTTAGTCATTTTACAATATGTTTGTATTTGGCCATTTACT GTAATCACATTTTTATATCTGTACAATGACACTTTTTGCAGTTGTGGGGTAGTGTGTAACACTGTCCATCTTGCATCATTGAAACTACTA CAATGATACTATCATTTAATAATATTAATATTACTTGAAATAGACTAAGATAAAGAAAAGGGGTCTGTATGATGTGCAGTTTTGTGCCTT TATGTATTTGCCTTGTTCTTTGTCGAATGTGTGAAATTCCGTACTGTGGTTTTTCCTATAATAGAAAGTAGAGCTGTGTATTAAATTAGA CTGTGTCTCTCTGATACCTTTACACTACTGAGAATAGCATGGTTTTGGCCATGTAAACCAATTTTCAAAGTTCTAATGACATAGCCATGT GTTTTTGGTTTTTTATATTTCATTTTAAAATTTGAGTATCACCATACATTAATTAATACTCCTGTAGTAGATAAGCTGTCATTAAGTAAT TCCCAAAAAAAGGGCCATTTGCTTGCATTACTTTGAATTTAATGTTGCGCTTGTGCACTGTGTTAATATTGTTTGTGATGGATTGGACGT TGTGACTCTTGCCTTTTAAGAAGAAAAAAAAGATAGGACAAAGTATTTGAAGCTCTTAAAATGTACATATTTTGGTTCTTCTATCTCAAA TTATTTAAAATGCATAATTCACATTTTTGTAATAATTCTATGCAATTTTGTGGCATGATGTTTCTTCCACTTGTAATTTTATGTGCTTTC >52748_52748_1_MED26-PLCB1_MED26_chr19_16738683_ENST00000263390_PLCB1_chr20_8608941_ENST00000338037_length(amino acids)=1158AA_BP=18 MTAAPASPQQIRDRLLQAIDPQSNDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSR DAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKP YLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFIN SSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSP KQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFEPSSPGAGEAD TESDDDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIY PKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFL SDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPTLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRN ERNQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKKEADPGETPSEAPSEARTTPAENGVNHTT TLTPKPPSQALHSQPAPGSVKAPAKTEDLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQND YLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEE CQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDE -------------------------------------------------------------- >52748_52748_2_MED26-PLCB1_MED26_chr19_16738683_ENST00000263390_PLCB1_chr20_8608941_ENST00000378637_length(transcript)=3940nt_BP=335nt TCACTGGAGTTTGGTTCTCGAGGCGGCGGCAGCGAGCGGCGGCGGCTCCGGCGGCTCCTCCTCCTCCTTTGGTGGCGGCGGCGGCCCGGG ACCGAGACCCGGCCCCGGCTCCCCTCTCCGCCACCCCGCGCGCCCCCAACCCCCCGGCGCCGCGGGGAACATGCGGCTCCGGCTCCCGGA GGCCGGCGAGTGAGTGACCCCCGTCCCCCGCCTCAGCCCGCCCGCCCGCTGGCCCGGCCGCAACCCCCCGCCTCGCCCAGGCAATGACAG CGGCTCCGGCGTCTCCGCAGCAGATCAGGGACCGGCTGCTGCAGGCCATCGACCCCCAGAGCAACGACCCCAAATTACGTGAACTTTTGG ATGTGGGGAACATCGGGCGCCTGGAGCAGCGCATGATCACAGTGGTGTATGGGCCTGACCTCGTGAACATCTCCCATTTGAATCTCGTGG CTTTCCAAGAAGAAGTGGCCAAGGAATGGACAAATGAGGTTTTCAGTTTGGCAACAAACCTGCTGGCCCAAAACATGTCCAGGGATGCAT TTCTGGAAAAAGCCTATACTAAACTTAAGCTGCAAGTCACTCCAGAAGGGCGTATTCCTCTCAAAAACATATATCGCTTGTTTTCAGCAG ATCGGAAGCGAGTTGAAACTGCTTTAGAGGCTTGTAGTCTTCCATCTTCAAGGAATGATTCAATACCTCAAGAAGATTTCACTCCAGAAG TGTACAGAGTTTTCCTCAACAACCTTTGCCCTCGACCTGAAATTGATAACATCTTTTCAGAATTTGGTGCAAAAAGCAAACCATATCTTA CCGTTGATCAGATGATGGATTTTATCAACCTTAAGCAGCGAGATCCTCGGCTTAATGAAATACTTTATCCACCTCTAAAACAAGAGCAAG TCCAAGTATTGATTGAGAAGTATGAACCCAACAACAGCCTCGCCAGAAAAGGACAAATATCAGTGGATGGGTTCATGCGCTATCTGAGTG GAGAAGAAAACGGAGTCGTTTCACCTGAGAAACTGGATTTGAATGAAGACATGTCTCAGCCCCTTTCTCACTATTTCATTAATTCCTCGC ACAACACCTACCTCACAGCTGGCCAACTGGCTGGAAACTCCTCTGTTGAGATGTATCGCCAAGTGCTCCTGTCTGGTTGTCGCTGTGTGG AGCTGGACTGCTGGAAGGGACGGACTGCAGAAGAGGAACCTGTCATCACCCATGGCTTCACCATGACAACTGAAATATCTTTCAAGGAAG TGATAGAAGCAATTGCGGAGTGTGCATTTAAGACTTCACCTTTTCCAATTCTCCTTTCGTTTGAGAACCATGTGGATTCCCCAAAGCAGC AAGCCAAGATGGCGGAGTACTGCCGACTGATCTTTGGGGATGCCCTTCTCATGGAGCCCCTGGAAAAATATCCACTGGAATCTGGAGTTC CTCTTCCAAGCCCTATGGATTTAATGTATAAAATTTTGGTGAAAAATAAGAAGAAATCACACAAGTCATCAGAAGGAAGCGGCAAAAAGA AGCTCTCAGAACAAGCCTCCAACACCTACAGTGACTCCTCCAGCATGTTCGAGCCCTCATCCCCAGGAGCCGGAGAAGCTGATACGGAAA GTGACGACGACGATGATGATGATGACTGTAAAAAATCTTCAATGGATGAGGGGACTGCTGGAAGTGAGGCTATGGCCACAGAAGAAATGT CTAATCTGGTGAACTATATTCAGCCAGTCAAGTTTGAGTCATTTGAAATTTCAAAAAAAAGAAATAAAAGTTTTGAAATGTCTTCCTTCG TGGAAACCAAAGGACTTGAACAACTCACCAAGTCTCCAGTGGAATTTGTAGAATATAACAAAATGCAGCTTAGCAGGATATATCCAAAAG GAACACGTGTGGATTCATCCAACTATATGCCTCAGCTCTTCTGGAATGCAGGTTGTCAGATGGTGGCACTTAATTTCCAGACAATGGACC TGGCTATGCAAATAAATATGGGGATGTATGAATACAACGGGAAGAGTGGCTACAGATTGAAGCCAGAGTTCATGAGGAGGCCTGACAAGC ATTTTGATCCATTTACTGAAGGCATCGTAGATGGGATAGTGGCAAACACTTTGTCTGTTAAGATTATTTCAGGTCAGTTTCTTTCTGATA AGAAAGTTGGGACTTACGTGGAAGTAGATATGTTTGGTTTGCCTGTGGATACAAGGAGGAAGGCATTTAAGACCAAAACATCCCAAGGAA ATGCTGTGAATCCTGTCTGGGAAGAAGAACCTATTGTGTTCAAAAAGGTGGTTCTTCCTACTCTGGCCTGTTTGAGAATAGCAGTTTATG AAGAAGGAGGTAAATTCATTGGCCACCGTATCTTGCCAGTGCAAGCCATTCGGCCAGGCTATCACTATATCTGTCTAAGGAATGAAAGGA ACCAGCCTCTGACGCTGCCTGCTGTCTTTGTCTACATAGAAGTGAAAGACTATGTGCCAGACACATATGCAGATGTCATCGAAGCTTTAT CAAACCCAATCCGATATGTGAACCTGATGGAACAGAGAGCTAAGCAATTGGCTGCTTTGACACTGGAAGATGAAGAAGAAGTAAAGAAAG AGGCTGATCCTGGAGAAACACCATCAGAGGCTCCAAGTGAAGCGAGAACGACTCCAGCAGAAAATGGGGTGAATCACACTACAACCCTGA CACCCAAGCCACCCTCCCAGGCTCTCCACAGCCAGCCAGCTCCAGGTTCTGTAAAGGCACCTGCCAAAACAGAAGATCTTATTCAGAGTG TCTTAACAGAAGTGGAAGCACAGACCATCGAAGAACTAAAGCAACAGAAATCGTTTGTGAAACTTCAAAAGAAACACTACAAAGAAATGA AAGACCTGGTTAAGAGACACCACAAGAAAACCACTGACCTTATCAAAGAACACACTACCAAGTATAATGAAATTCAGAATGACTACTTGA GAAGGAGAGCCGCTTTGGAAAAGTCCGCCAAAAAGGACAGTAAGAAAAAATCGGAACCCAGCAGCCCTGATCATGGTTCATCAACGATTG AGCAAGACCTCGCTGCTCTGGATGCTGAAATGACCCAAAAGTTAATAGACTTGAAGGACAAACAACAGCAGCAGCTGCTTAATCTTCGGC AAGAACAGTATTATAGTGAAAAATACCAGAAGCGAGAACATATTAAACTGCTTATTCAAAAGTTGACGGATGTCGCAGAAGAGTGTCAGA ACAATCAGTTAAAGAAGCTCAAAGAAATCTGTGAGAAAGAAAAGAAAGAATTAAAGAAGAAAATGGATAAAAAGAGGCAGGAGAAGATAA CAGAAGCTAAATCCAAAGACAAAAGTCAGATGGAAGAGGAGAAGACAGAGATGATCCGGTCATATATCCAGGAAGTGGTGCAGTATATCA AGAGGCTAGAAGAAGCGCAAAGTAAACGGCAAGAAAAACTCGTAGAGAAACACAAGGAAATACGTCAGCAGATCCTGGATGAAAAGCCCA AGGGGGAAGGTTCCTCCTCATTCTTGTCGGAAACTTGCCATGAGGATCCCTCTGTTTCCCCCAACTTTACTCCCCCCAACCCTCAAGCTC TCAAGTGGTGACCACCGTCCTTCCGGCCAGGTAGGACTGGATGGGAGGGGTCGCTTTTGAGAGAAGGGTGGTGTGTAGCCATCCAGTTTT CAGGCATCACGGACTTGCTCGTTTGTCCTTCATCCTCCCTTTCTCTACATTCCCATCTTTTTTTTCTGCTAAAGTTCCCAGCCACACCCA TGATCATTTCCTCATCCTTTCTGCCTTCCTCTGGTATTAATTTCTCCATCATTGTGCTCTCTCTTCCTGACATAAATCTCATTCTTCCAT >52748_52748_2_MED26-PLCB1_MED26_chr19_16738683_ENST00000263390_PLCB1_chr20_8608941_ENST00000378637_length(amino acids)=1115AA_BP=18 MTAAPASPQQIRDRLLQAIDPQSNDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSR DAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKP YLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFIN SSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSP KQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFEPSSPGAGEAD TESDDDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIY PKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFL SDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPTLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRN ERNQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKKEADPGETPSEAPSEARTTPAENGVNHTT TLTPKPPSQALHSQPAPGSVKAPAKTEDLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQND YLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEE CQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDE -------------------------------------------------------------- >52748_52748_3_MED26-PLCB1_MED26_chr19_16738683_ENST00000263390_PLCB1_chr20_8608941_ENST00000378641_length(transcript)=6909nt_BP=335nt TCACTGGAGTTTGGTTCTCGAGGCGGCGGCAGCGAGCGGCGGCGGCTCCGGCGGCTCCTCCTCCTCCTTTGGTGGCGGCGGCGGCCCGGG ACCGAGACCCGGCCCCGGCTCCCCTCTCCGCCACCCCGCGCGCCCCCAACCCCCCGGCGCCGCGGGGAACATGCGGCTCCGGCTCCCGGA GGCCGGCGAGTGAGTGACCCCCGTCCCCCGCCTCAGCCCGCCCGCCCGCTGGCCCGGCCGCAACCCCCCGCCTCGCCCAGGCAATGACAG CGGCTCCGGCGTCTCCGCAGCAGATCAGGGACCGGCTGCTGCAGGCCATCGACCCCCAGAGCAACGACCCCAAATTACGTGAACTTTTGG ATGTGGGGAACATCGGGCGCCTGGAGCAGCGCATGATCACAGTGGTGTATGGGCCTGACCTCGTGAACATCTCCCATTTGAATCTCGTGG CTTTCCAAGAAGAAGTGGCCAAGGAATGGACAAATGAGGTTTTCAGTTTGGCAACAAACCTGCTGGCCCAAAACATGTCCAGGGATGCAT TTCTGGAAAAAGCCTATACTAAACTTAAGCTGCAAGTCACTCCAGAAGGGCGTATTCCTCTCAAAAACATATATCGCTTGTTTTCAGCAG ATCGGAAGCGAGTTGAAACTGCTTTAGAGGCTTGTAGTCTTCCATCTTCAAGGAATGATTCAATACCTCAAGAAGATTTCACTCCAGAAG TGTACAGAGTTTTCCTCAACAACCTTTGCCCTCGACCTGAAATTGATAACATCTTTTCAGAATTTGGTGCAAAAAGCAAACCATATCTTA CCGTTGATCAGATGATGGATTTTATCAACCTTAAGCAGCGAGATCCTCGGCTTAATGAAATACTTTATCCACCTCTAAAACAAGAGCAAG TCCAAGTATTGATTGAGAAGTATGAACCCAACAACAGCCTCGCCAGAAAAGGACAAATATCAGTGGATGGGTTCATGCGCTATCTGAGTG GAGAAGAAAACGGAGTCGTTTCACCTGAGAAACTGGATTTGAATGAAGACATGTCTCAGCCCCTTTCTCACTATTTCATTAATTCCTCGC ACAACACCTACCTCACAGCTGGCCAACTGGCTGGAAACTCCTCTGTTGAGATGTATCGCCAAGTGCTCCTGTCTGGTTGTCGCTGTGTGG AGCTGGACTGCTGGAAGGGACGGACTGCAGAAGAGGAACCTGTCATCACCCATGGCTTCACCATGACAACTGAAATATCTTTCAAGGAAG TGATAGAAGCAATTGCGGAGTGTGCATTTAAGACTTCACCTTTTCCAATTCTCCTTTCGTTTGAGAACCATGTGGATTCCCCAAAGCAGC AAGCCAAGATGGCGGAGTACTGCCGACTGATCTTTGGGGATGCCCTTCTCATGGAGCCCCTGGAAAAATATCCACTGGAATCTGGAGTTC CTCTTCCAAGCCCTATGGATTTAATGTATAAAATTTTGGTGAAAAATAAGAAGAAATCACACAAGTCATCAGAAGGAAGCGGCAAAAAGA AGCTCTCAGAACAAGCCTCCAACACCTACAGTGACTCCTCCAGCATGTTCGAGCCCTCATCCCCAGGAGCCGGAGAAGCTGATACGGAAA GTGACGACGACGATGATGATGATGACTGTAAAAAATCTTCAATGGATGAGGGGACTGCTGGAAGTGAGGCTATGGCCACAGAAGAAATGT CTAATCTGGTGAACTATATTCAGCCAGTCAAGTTTGAGTCATTTGAAATTTCAAAAAAAAGAAATAAAAGTTTTGAAATGTCTTCCTTCG TGGAAACCAAAGGACTTGAACAACTCACCAAGTCTCCAGTGGAATTTGTAGAATATAACAAAATGCAGCTTAGCAGGATATATCCAAAAG GAACACGTGTGGATTCATCCAACTATATGCCTCAGCTCTTCTGGAATGCAGGTTGTCAGATGGTGGCACTTAATTTCCAGACAATGGACC TGGCTATGCAAATAAATATGGGGATGTATGAATACAACGGGAAGAGTGGCTACAGATTGAAGCCAGAGTTCATGAGGAGGCCTGACAAGC ATTTTGATCCATTTACTGAAGGCATCGTAGATGGGATAGTGGCAAACACTTTGTCTGTTAAGATTATTTCAGGTCAGTTTCTTTCTGATA AGAAAGTTGGGACTTACGTGGAAGTAGATATGTTTGGTTTGCCTGTGGATACAAGGAGGAAGGCATTTAAGACCAAAACATCCCAAGGAA ATGCTGTGAATCCTGTCTGGGAAGAAGAACCTATTGTGTTCAAAAAGGTGGTTCTTCCTACTCTGGCCTGTTTGAGAATAGCAGTTTATG AAGAAGGAGGTAAATTCATTGGCCACCGTATCTTGCCAGTGCAAGCCATTCGGCCAGGCTATCACTATATCTGTCTAAGGAATGAAAGGA ACCAGCCTCTGACGCTGCCTGCTGTCTTTGTCTACATAGAAGTGAAAGACTATGTGCCAGACACATATGCAGATGTCATCGAAGCTTTAT CAAACCCAATCCGATATGTGAACCTGATGGAACAGAGAGCTAAGCAATTGGCTGCTTTGACACTGGAAGATGAAGAAGAAGTAAAGAAAG AGGCTGATCCTGGAGAAACACCATCAGAGGCTCCAAGTGAAGCGAGAACGACTCCAGCAGAAAATGGGGTGAATCACACTACAACCCTGA CACCCAAGCCACCCTCCCAGGCTCTCCACAGCCAGCCAGCTCCAGGTTCTGTAAAGGCACCTGCCAAAACAGAAGATCTTATTCAGAGTG TCTTAACAGAAGTGGAAGCACAGACCATCGAAGAACTAAAGCAACAGAAATCGTTTGTGAAACTTCAAAAGAAACACTACAAAGAAATGA AAGACCTGGTTAAGAGACACCACAAGAAAACCACTGACCTTATCAAAGAACACACTACCAAGTATAATGAAATTCAGAATGACTACTTGA GAAGGAGAGCCGCTTTGGAAAAGTCCGCCAAAAAGGACAGTAAGAAAAAATCGGAACCCAGCAGCCCTGATCATGGTTCATCAACGATTG AGCAAGACCTCGCTGCTCTGGATGCTGAAATGACCCAAAAGTTAATAGACTTGAAGGACAAACAACAGCAGCAGCTGCTTAATCTTCGGC AAGAACAGTATTATAGTGAAAAATACCAGAAGCGAGAACATATTAAACTGCTTATTCAAAAGTTGACGGATGTCGCAGAAGAGTGTCAGA ACAATCAGTTAAAGAAGCTCAAAGAAATCTGTGAGAAAGAAAAGAAAGAATTAAAGAAGAAAATGGATAAAAAGAGGCAGGAGAAGATAA CAGAAGCTAAATCCAAAGACAAAAGTCAGATGGAAGAGGAGAAGACAGAGATGATCCGGTCATATATCCAGGAAGTGGTGCAGTATATCA AGAGGCTAGAAGAAGCGCAAAGTAAACGGCAAGAAAAACTCGTAGAGAAACACAAGGAAATACGTCAGCAGATCCTGGATGAAAAGCCCA AGGGGGAAGGTTCCTCCTCATTCTTGTCGGAAACTTGCCATGAGGATCCCTCTGTTTCCCCCAACTTTACTCCCCCCAACCCTCAAGCTC TCAAGTGGTGACCACCGTCCTTCCGGCCAGCTGCAGGTGGAGCTGGAGCAAGAATACCAAGACAAATTCAAAAGACTGCCCCTCGAGATT TTGGAATTCGTGCAGGAAGCCATGAAAGGAAAGATCAGTGAAGACAGCAATCACGGTTCTGCCCCTCTCTCCCTGTCCTCAGACCCTGGA AAAGTGAACCACAAGACTCCCTCCAGTGAGGAGCTGGGAGGAGACATCCCAGGAAAAGAATTTGATACTCCTCTGTGAATGCTCCTGCCA GGCCTTCAGAAATTGCATGGCCACTCCAGCGTCATCGGACTCTCTCTTATTACAAAGATCACTGCCCAGGACCATCTTCCCGAGAAGCAT CCCTTAGCCTAAAATCCACACCAAAGGGAGAGTTCCAGAGGAATCCATGAAGAATTCCCATGCCCAGGCTCCATGTGTCATGTGGAAACC TCCACAGGTCTGCTAGTGAAGAATGCATGTATGTGAGATTTTTGTTTTCTTTCCAATAGCAAATTCAAAGCAAGCAACTTGCAGGCTCCA TGGAACTTTTAATGAAGGACAGTGTCTTCTTTGAAGAAAATCAAGCTCGTGTTTTTATTCGAAGCTCTGGTGTAAAATATTTCAAAGTCA TAGAAATAGTTTGAGAAATGCATAGCATTATTTAACACTATTGAACAGCCGACTTTGAGCATTGTTTCTTCTAACTGCCCCTCAACTACC ATTATCTTCAAGTCAACATGCATATTACATTTTCATCCTTTGCTTTGCAAGCACTGGTGGCTTGCAGTTTGCTAATTTATTTATCATAGA GTCATCAATGTATTTGTTGCTGACATGGTTTTATTAGATACTGTAGTGATTCAAATAAGTTTTCTATTTGAAAAAAAAAATCACTTGATT GTATCCTTGCCCAGTGAAGCCATCCTAAGACTTAGCAATATGGATTGTACATTTGGCTGCATGAGCAAGTCGGCCGCACACTTCCAGACA GTGTGCTGTTTGAATTGACTATTTGCACTCAAAGTCTGGGTATTCATTGGTTATTGGCCTGAAATGATCAAATAACTACAAATGATCTGT TGAATAAAAATAGTTGAGCTGATATATGTTAAGCAGATATTCAATCAGAATGAACAGGTTCCGGTGGTTATTTTGCCGTTTGACATTTTT TATGGTTCATTTATTTTTAATATAGAGAGGAAGATTGAATATTTATCTAGAGAATACAAAGACCCACATGTAAATGATAGGTATTATCTC CATGTATATATGTACCCACTTAGTCATGTAAGTGCATATACACATACACACACATGAGTGTAGACATGTGTTTATTAATTGACAATGACC CAAATCTCTTCCACAAGACTTAAAACCAAATTCAGGGACAAATGGATAGAGAAGAAAAGGGTCAAACATCGAGATTACATGGATGTTAAA TTATATGGAGACGCTAAGAAATAATTGATGGAGCCATTGATGCAAACCGAAGTAGATTTAGAACTTATATGAATTTGATTTATATTTTGC AAGATCAAAAATTAGATGTTAAGTATCAGATTTTAAGCTTGTTTTAATGGTCAAAAAATTAGGACAGAAATAATATGGACATTTATTAGT ATCTTCCATAATTTTTAAGTCTGACACATTTCTATTTTATTCTAACATAAAAAAACTTCCATTATATATTTACTAAGTATATTTAATTCA CTTAACTCTGTCTTTATAAGTTCCTATTTTAGATGGAATAAGAGAAACAAATTATATCAAGGTAAAACTGATCAAAAGCATAATTGAAAG TTCTGAAAAAAGAAAAATAATAATATGTAGAAAAATGTAACTTAGAGAGTAACACATGAACATTGAAGTTAAAACCCAGAAGCCAGATGC TCACAGTTTTATTTTACTTTAAAATAAACCTGTCTGACTGTAGCTTTGTGAAATATCTTAAAACGCAAAAACCAATTGTGTCCTGAAAAT TGTTTCAAGAATTTAATATTTTTATGAAAATTATTTTATTTAACTTTAAGCAATAACTAGAGATTACAATTAAATTTTAATCAAAATGAA GGCTTAGTTCAAACATAAGGAAACAGTGTTTGATTAAAAAAAACACATCTAGTAAGACGTAAGGGGAAAATCACATCCTCTTTGGAGATG ATTATATTTTGATCTGAAGGGTTTGGGGTGTTCATTAGACACTTAATAAAACTTAACTTCCAATGAAAAAGAAATCTTTTGTAAATCATT CTACTTTTGCACTTTGAAAGAAAGGCGTTAATCATAAAGAAGCAAGAATGGTCAAAATCGAATGCTGCATTTTTATAAACAAAATTACAG ACTGTCTGAAATTGAAGAAGAATGAACTAATAATAGCATTCATAACCAAACACAATGATGATTATTGCAGAACATTGTATCACATTTTAG TCCAGAGATAGAATAAAGTTGAATAACCTTGACTTACACAAAACTGTTTTGGTAGTTGGATTTCATTATCTTAGTGAATTTAGTCATTTT ACAATATGTTTGTATTTGGCCATTTACTGTAATCACATTTTTATATCTGTACAATGACACTTTTTGCAGTTGTGGGGTAGTGTGTAACAC TGTCCATCTTGCATCATTGAAACTACTACAATGATACTATCATTTAATAATATTAATATTACTTGAAATAGACTAAGATAAAGAAAAGGG GTCTGTATGATGTGCAGTTTTGTGCCTTTATGTATTTGCCTTGTTCTTTGTCGAATGTGTGAAATTCCGTACTGTGGTTTTTCCTATAAT AGAAAGTAGAGCTGTGTATTAAATTAGACTGTGTCTCTCTGATACCTTTACACTACTGAGAATAGCATGGTTTTGGCCATGTAAACCAAT TTTCAAAGTTCTAATGACATAGCCATGTGTTTTTGGTTTTTTATATTTCATTTTAAAATTTGAGTATCACCATACATTAATTAATACTCC TGTAGTAGATAAGCTGTCATTAAGTAATTCCCAAAAAAAGGGCCATTTGCTTGCATTACTTTGAATTTAATGTTGCGCTTGTGCACTGTG TTAATATTGTTTGTGATGGATTGGACGTTGTGACTCTTGCCTTTTAAGAAGAAAAAAAAGATAGGACAAAGTATTTGAAGCTCTTAAAAT GTACATATTTTGGTTCTTCTATCTCAAATTATTTAAAATGCATAATTCACATTTTTGTAATAATTCTATGCAATTTTGTGGCATGATGTT >52748_52748_3_MED26-PLCB1_MED26_chr19_16738683_ENST00000263390_PLCB1_chr20_8608941_ENST00000378641_length(amino acids)=1115AA_BP=18 MTAAPASPQQIRDRLLQAIDPQSNDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSR DAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKP YLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFIN SSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSP KQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFEPSSPGAGEAD TESDDDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIY PKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFL SDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPTLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRN ERNQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKKEADPGETPSEAPSEARTTPAENGVNHTT TLTPKPPSQALHSQPAPGSVKAPAKTEDLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQND YLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEE CQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDE -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for MED26-PLCB1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for MED26-PLCB1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for MED26-PLCB1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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