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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MED26-SLC1A6 (FusionGDB2 ID:52750)

Fusion Gene Summary for MED26-SLC1A6

Fusion gene summary

Fusion gene information	Fusion gene name: MED26-SLC1A6
	Fusion gene ID: 52750
		Hgene	Tgene
	Gene symbol	MED26	SLC1A6
	Gene ID	9441	6511
	Gene name	mediator complex subunit 26	solute carrier family 1 member 6
	Synonyms	CRSP7\|CRSP70	EAAT4
	Cytomap	19p13.11	19p13.12
	Type of gene	protein-coding	protein-coding
	Description	mediator of RNA polymerase II transcription subunit 26ARC70CRSP complex subunit 7activator-recruited cofactor 70 kDa componentcofactor required for Sp1 transcriptional activation subunit 7cofactor required for Sp1 transcriptional activation, subunit	excitatory amino acid transporter 4sodium-dependent glutamate/aspartate transportersolute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
	Modification date	20200313	20200313
	UniProtAcc	O95402	.
	Ensembl transtripts involved in fusion gene	ENST00000263390,	ENST00000544886, ENST00000598504, ENST00000600144, ENST00000221742, ENST00000430939,
Fusion gene scores	* DoF score	16 X 4 X 12=768	7 X 6 X 7=294
	# samples	18	9
	** MAII score	log2(18/768*10)=-2.09310940439148 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/294*10)=-1.70781924850669 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MED26 [Title/Abstract] AND SLC1A6 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MED26(16738683)-SLC1A6(15083729), # samples:2
Anticipated loss of major functional domain due to fusion event.	MED26-SLC1A6 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. MED26-SLC1A6 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. MED26-SLC1A6 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. MED26-SLC1A6 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MED26	GO:0006357	regulation of transcription by RNA polymerase II	15989967

Fusion gene breakpoints across MED26 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SLC1A6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-61-1728-01A	MED26	chr19	16738683	-	SLC1A6	chr19	15067521	-
ChimerDB4	OV	TCGA-61-1728-01A	MED26	chr19	16738683	-	SLC1A6	chr19	15075173	-
ChimerDB4	OV	TCGA-61-1728-01A	MED26	chr19	16738683	-	SLC1A6	chr19	15083729	-
ChimerDB4	OV	TCGA-61-1728	MED26	chr19	16738682	-	SLC1A6	chr19	15067521	-
ChimerDB4	OV	TCGA-61-1728	MED26	chr19	16738682	-	SLC1A6	chr19	15075173	-
ChimerDB4	OV	TCGA-61-1728	MED26	chr19	16738682	-	SLC1A6	chr19	15083730	-

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Fusion Gene ORF analysis for MED26-SLC1A6

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000263390	ENST00000544886	MED26	chr19	16738683	-	SLC1A6	chr19	15083729	-
5CDS-5UTR	ENST00000263390	ENST00000544886	MED26	chr19	16738682	-	SLC1A6	chr19	15083730	-
5CDS-5UTR	ENST00000263390	ENST00000598504	MED26	chr19	16738683	-	SLC1A6	chr19	15083729	-
5CDS-5UTR	ENST00000263390	ENST00000598504	MED26	chr19	16738682	-	SLC1A6	chr19	15083730	-
5CDS-5UTR	ENST00000263390	ENST00000600144	MED26	chr19	16738683	-	SLC1A6	chr19	15083729	-
5CDS-5UTR	ENST00000263390	ENST00000600144	MED26	chr19	16738682	-	SLC1A6	chr19	15083730	-
5CDS-intron	ENST00000263390	ENST00000544886	MED26	chr19	16738683	-	SLC1A6	chr19	15067521	-
5CDS-intron	ENST00000263390	ENST00000544886	MED26	chr19	16738682	-	SLC1A6	chr19	15067521	-
5CDS-intron	ENST00000263390	ENST00000598504	MED26	chr19	16738683	-	SLC1A6	chr19	15067521	-
5CDS-intron	ENST00000263390	ENST00000598504	MED26	chr19	16738682	-	SLC1A6	chr19	15067521	-
5CDS-intron	ENST00000263390	ENST00000600144	MED26	chr19	16738683	-	SLC1A6	chr19	15067521	-
5CDS-intron	ENST00000263390	ENST00000600144	MED26	chr19	16738682	-	SLC1A6	chr19	15067521	-
Frame-shift	ENST00000263390	ENST00000221742	MED26	chr19	16738683	-	SLC1A6	chr19	15067521	-
Frame-shift	ENST00000263390	ENST00000221742	MED26	chr19	16738683	-	SLC1A6	chr19	15075173	-
Frame-shift	ENST00000263390	ENST00000221742	MED26	chr19	16738682	-	SLC1A6	chr19	15067521	-
Frame-shift	ENST00000263390	ENST00000221742	MED26	chr19	16738682	-	SLC1A6	chr19	15075173	-
Frame-shift	ENST00000263390	ENST00000430939	MED26	chr19	16738683	-	SLC1A6	chr19	15067521	-
Frame-shift	ENST00000263390	ENST00000430939	MED26	chr19	16738683	-	SLC1A6	chr19	15075173	-
Frame-shift	ENST00000263390	ENST00000430939	MED26	chr19	16738682	-	SLC1A6	chr19	15067521	-
Frame-shift	ENST00000263390	ENST00000430939	MED26	chr19	16738682	-	SLC1A6	chr19	15075173	-
Frame-shift	ENST00000263390	ENST00000544886	MED26	chr19	16738683	-	SLC1A6	chr19	15075173	-
Frame-shift	ENST00000263390	ENST00000544886	MED26	chr19	16738682	-	SLC1A6	chr19	15075173	-
Frame-shift	ENST00000263390	ENST00000598504	MED26	chr19	16738683	-	SLC1A6	chr19	15075173	-
Frame-shift	ENST00000263390	ENST00000598504	MED26	chr19	16738682	-	SLC1A6	chr19	15075173	-
Frame-shift	ENST00000263390	ENST00000600144	MED26	chr19	16738683	-	SLC1A6	chr19	15075173	-
Frame-shift	ENST00000263390	ENST00000600144	MED26	chr19	16738682	-	SLC1A6	chr19	15075173	-
In-frame	ENST00000263390	ENST00000221742	MED26	chr19	16738683	-	SLC1A6	chr19	15083729	-
In-frame	ENST00000263390	ENST00000221742	MED26	chr19	16738682	-	SLC1A6	chr19	15083730	-
In-frame	ENST00000263390	ENST00000430939	MED26	chr19	16738683	-	SLC1A6	chr19	15083729	-
In-frame	ENST00000263390	ENST00000430939	MED26	chr19	16738682	-	SLC1A6	chr19	15083730	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000263390	MED26	chr19	16738683	-	ENST00000430939	SLC1A6	chr19	15083729	-	1993	335	263	1831	522
ENST00000263390	MED26	chr19	16738683	-	ENST00000221742	SLC1A6	chr19	15083729	-	2054	335	343	2037	564
ENST00000263390	MED26	chr19	16738682	-	ENST00000430939	SLC1A6	chr19	15083730	-	1993	335	263	1831	522
ENST00000263390	MED26	chr19	16738682	-	ENST00000221742	SLC1A6	chr19	15083730	-	2054	335	343	2037	564

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000263390	ENST00000430939	MED26	chr19	16738683	-	SLC1A6	chr19	15083729	-	0.01632094	0.983679
ENST00000263390	ENST00000221742	MED26	chr19	16738683	-	SLC1A6	chr19	15083729	-	0.01355212	0.98644793
ENST00000263390	ENST00000430939	MED26	chr19	16738682	-	SLC1A6	chr19	15083730	-	0.01632094	0.983679
ENST00000263390	ENST00000221742	MED26	chr19	16738682	-	SLC1A6	chr19	15083730	-	0.01355212	0.98644793

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Fusion Genomic Features for MED26-SLC1A6

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MED26-SLC1A6

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:16738683/chr19:15083729)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MED26 O95402	.
FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SLC1A6

chr19:16738682

chr19:15083730

ENST00000221742

-1

371_401

565.0

Intramembrane

Discontinuously helical

Tgene

SLC1A6

chr19:16738682

chr19:15083730

ENST00000221742

-1

451_484

565.0

Intramembrane

Discontinuously helical

Tgene

SLC1A6

chr19:16738683

chr19:15083729

ENST00000221742

-1

371_401

565.0

Intramembrane

Discontinuously helical

Tgene

SLC1A6

chr19:16738683

chr19:15083729

ENST00000221742

-1

451_484

565.0

Intramembrane

Discontinuously helical

Tgene

SLC1A6

chr19:16738682

chr19:15083730

ENST00000221742

-1

388_390

565.0

Region

Aspartate binding

Tgene

SLC1A6

chr19:16738682

chr19:15083730

ENST00000221742

-1

468_472

565.0

Region

Aspartate binding

Tgene

SLC1A6

chr19:16738683

chr19:15083729

ENST00000221742

-1

388_390

565.0

Region

Aspartate binding

Tgene

SLC1A6

chr19:16738683

chr19:15083729

ENST00000221742

-1

468_472

565.0

Region

Aspartate binding

Tgene

SLC1A6

chr19:16738682

chr19:15083730

ENST00000221742

-1

133_153

565.0

Transmembrane

Helical

Tgene

SLC1A6

chr19:16738682

chr19:15083730

ENST00000221742

-1

262_285

565.0

Transmembrane

Helical%3B Name%3D4

Tgene

SLC1A6

chr19:16738682

chr19:15083730

ENST00000221742

-1

295_322

565.0

Transmembrane

Helical%3B Name%3D5

Tgene

SLC1A6

chr19:16738682

chr19:15083730

ENST00000221742

-1

344_365

565.0

Transmembrane

Helical%3B Name%3D6

Tgene

SLC1A6

chr19:16738682

chr19:15083730

ENST00000221742

-1

411_437

565.0

Transmembrane

Helical%3B Name%3D7

Tgene

SLC1A6

chr19:16738682

chr19:15083730

ENST00000221742

-1

498_519

565.0

Transmembrane

Helical%3B Name%3D8

Tgene

SLC1A6

chr19:16738682

chr19:15083730

ENST00000221742

-1

99_119

565.0

Transmembrane

Helical

Tgene

SLC1A6

chr19:16738683

chr19:15083729

ENST00000221742

-1

133_153

565.0

Transmembrane

Helical

Tgene

SLC1A6

chr19:16738683

chr19:15083729

ENST00000221742

-1

262_285

565.0

Transmembrane

Helical%3B Name%3D4

Tgene

SLC1A6

chr19:16738683

chr19:15083729

ENST00000221742

-1

295_322

565.0

Transmembrane

Helical%3B Name%3D5

Tgene

SLC1A6

chr19:16738683

chr19:15083729

ENST00000221742

-1

344_365

565.0

Transmembrane

Helical%3B Name%3D6

Tgene

SLC1A6

chr19:16738683

chr19:15083729

ENST00000221742

-1

411_437

565.0

Transmembrane

Helical%3B Name%3D7

Tgene

SLC1A6

chr19:16738683

chr19:15083729

ENST00000221742

-1

498_519

565.0

Transmembrane

Helical%3B Name%3D8

Tgene

SLC1A6

chr19:16738683

chr19:15083729

ENST00000221742

-1

99_119

565.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MED26

chr19:16738682

chr19:15083730

ENST00000263390

228_325

601.0

Compositional bias

Note=Pro-rich

Hgene

MED26

chr19:16738683

chr19:15083729

ENST00000263390

228_325

601.0

Compositional bias

Note=Pro-rich

Hgene

MED26

chr19:16738682

chr19:15083730

ENST00000263390

10_87

601.0

Domain

TFIIS N-terminal

Hgene

MED26

chr19:16738683

chr19:15083729

ENST00000263390

10_87

601.0

Domain

TFIIS N-terminal

Tgene

SLC1A6

chr19:16738682

chr19:15083730

ENST00000221742

-1

1_55

565.0

Topological domain

Cytoplasmic

Tgene

SLC1A6

chr19:16738683

chr19:15083729

ENST00000221742

-1

1_55

565.0

Topological domain

Cytoplasmic

Tgene

SLC1A6

chr19:16738682

chr19:15083730

ENST00000221742

-1

56_76

565.0

Transmembrane

Helical

Tgene

SLC1A6

chr19:16738683

chr19:15083729

ENST00000221742

-1

56_76

565.0

Transmembrane

Helical

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Fusion Gene Sequence for MED26-SLC1A6

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>52750_52750_1_MED26-SLC1A6_MED26_chr19_16738682_ENST00000263390_SLC1A6_chr19_15083730_ENST00000221742_length(transcript)=2054nt_BP=335nt
TCACTGGAGTTTGGTTCTCGAGGCGGCGGCAGCGAGCGGCGGCGGCTCCGGCGGCTCCTCCTCCTCCTTTGGTGGCGGCGGCGGCCCGGG
ACCGAGACCCGGCCCCGGCTCCCCTCTCCGCCACCCCGCGCGCCCCCAACCCCCCGGCGCCGCGGGGAACATGCGGCTCCGGCTCCCGGA
GGCCGGCGAGTGAGTGACCCCCGTCCCCCGCCTCAGCCCGCCCGCCCGCTGGCCCGGCCGCAACCCCCCGCCTCGCCCAGGCAATGACAG
CGGCTCCGGCGTCTCCGCAGCAGATCAGGGACCGGCTGCTGCAGGCCATCGACCCCCAGAGCAACGATAGACCATGAGCAGCCATGGCAA
CAGCCTGTTCCTGCGGGAGAGCGGCCAGCGGCTGGGCCGGGTGGGCTGGCTGCAGCGGCTGCAGGAAAGCCTGCAGCAGAGAGCACTGCG
CACGCGCCTGCGCCTGCAGACCATGACCCTCGAGCACGTGCTGCGCTTCCTGCGCCGAAACGCCTTCATTCTGCTGACGGTCAGCGCCGT
GGTCATTGGGGTCAGCCTGGCCTTTGCCCTGCGCCCATATCAGCTCACCTACCGCCAGATCAAGTACTTCTCTTTTCCTGGAGAGCTTCT
GATGAGGATGCTGCAGATGCTGGTGTTACCTCTCATTGTCTCCAGCCTGGTCACAGGTATGGCATCCCTGGACAACAAGGCCACGGGGCG
GATGGGGATGCGGGCAGCTGTGTACTACATGGTGACCACCATCATCGCGGTCTTCATCGGCATCCTCATGGTCACCATCATCCATCCCGG
GAAGGGCTCCAAGGAGGGGCTGCACCGGGAGGGCCGGATCGAGACCATCCCCACAGCTGATGCCTTCATGGACCTGATCAGAAATATGTT
TCCACCAAACCTTGTGGAGGCCTGCTTCAAACAGTTCAAGACGCAGTACAGCACGAGGGTGGTAACCAGGACCATGGTGAGGACAGAGAA
CGGGTCTGAGCCGGGTGCCTCCATGCCTCCTCCATTCTCAGTGGAGAACGGAACCAGCTTCCTGGAAAATGTCACTCGGGCCTTGGGTAC
CCTGCAGGAGATGCTGAGCTTTGAGGAGACTGTACCCGTGCCTGGCTCCGCCAATGGCATCAACGCCCTGGGCCTCGTGGTCTTCTCTGT
GGCCTTTGGGCTGGTCATTGGTGGCATGAAACACAAGGGCAGAGTCCTCAGGGACTTCTTCGACAGCCTCAATGAGGCTATTATGAGGCT
GGTGGGCATCATTATCTGGTATGCACCTGTGGGCATCCTGTTCCTGATTGCTGGGAAGATTCTGGAGATGGAAGACATGGCCGTCCTGGG
GGGTCAGCTGGGCATGTACACCCTGACCGTCATCGTGGGCCTGTTCCTCCATGCCGGCATTGTCCTTCCCCTCATCTACTTCCTCGTCAC
TCACCGGAACCCCTTCCCCTTCATTGGGGGCATGCTACAAGCCCTCATCACCGCTATGGGCACGTCTTCCAGCTCGGCAACGCTGCCCAT
CACCTTCCGCTGCCTGGAGGAGGGCCTGGGTGTGGACCGCCGCATCACCAGGTTCGTCCTGCCCGTGGGCGCCACGGTCAACATGGATGG
CACTGCCCTCTACGAGGCCCTGGCTGCCATCTTCATTGCTCAAGTTAACAACTACGAGCTCAACCTGGGTCAGATCACAACCATCAGCAT
CACGGCCACAGCAGCCAGTGTTGGGGCTGCTGGCATCCCCCAGGCGGGTCTGGTCACCATGGTCATTGTGCTTACGTCGGTCGGCTTGCC
CACGGAAGACATCACGCTCATCATTGCCGTGGACTGGTTCCTTGACCGGCTTCGCACAATGACCAACGTACTGGGGGACTCAATTGGAGC
GGCCGTCATCGAGCACTTGTCTCAGCGGGAGCTGGAGCTTCAGGAAGCTGAGCTTACCCTCCCCAGCCTGGGGAAACCCTACAAGTCCCT

>52750_52750_1_MED26-SLC1A6_MED26_chr19_16738682_ENST00000263390_SLC1A6_chr19_15083730_ENST00000221742_length(amino acids)=564AA_BP=
MSSHGNSLFLRESGQRLGRVGWLQRLQESLQQRALRTRLRLQTMTLEHVLRFLRRNAFILLTVSAVVIGVSLAFALRPYQLTYRQIKYFS
FPGELLMRMLQMLVLPLIVSSLVTGMASLDNKATGRMGMRAAVYYMVTTIIAVFIGILMVTIIHPGKGSKEGLHREGRIETIPTADAFMD
LIRNMFPPNLVEACFKQFKTQYSTRVVTRTMVRTENGSEPGASMPPPFSVENGTSFLENVTRALGTLQEMLSFEETVPVPGSANGINALG
LVVFSVAFGLVIGGMKHKGRVLRDFFDSLNEAIMRLVGIIIWYAPVGILFLIAGKILEMEDMAVLGGQLGMYTLTVIVGLFLHAGIVLPL
IYFLVTHRNPFPFIGGMLQALITAMGTSSSSATLPITFRCLEEGLGVDRRITRFVLPVGATVNMDGTALYEALAAIFIAQVNNYELNLGQ
ITTISITATAASVGAAGIPQAGLVTMVIVLTSVGLPTEDITLIIAVDWFLDRLRTMTNVLGDSIGAAVIEHLSQRELELQEAELTLPSLG

--------------------------------------------------------------
>52750_52750_2_MED26-SLC1A6_MED26_chr19_16738682_ENST00000263390_SLC1A6_chr19_15083730_ENST00000430939_length(transcript)=1993nt_BP=335nt
TCACTGGAGTTTGGTTCTCGAGGCGGCGGCAGCGAGCGGCGGCGGCTCCGGCGGCTCCTCCTCCTCCTTTGGTGGCGGCGGCGGCCCGGG
ACCGAGACCCGGCCCCGGCTCCCCTCTCCGCCACCCCGCGCGCCCCCAACCCCCCGGCGCCGCGGGGAACATGCGGCTCCGGCTCCCGGA
GGCCGGCGAGTGAGTGACCCCCGTCCCCCGCCTCAGCCCGCCCGCCCGCTGGCCCGGCCGCAACCCCCCGCCTCGCCCAGGCAATGACAG
CGGCTCCGGCGTCTCCGCAGCAGATCAGGGACCGGCTGCTGCAGGCCATCGACCCCCAGAGCAACATAGACCATGAGCAGCCATGGCAAC
AGCCTGTTCCTGCGGGAGAGCGGCCAGCGGCTGGGCCGGGTGGGCTGGCTGCAGCGGCTGCAGGAAAGCCTGCAGCAGAGAGCACTGCGC
ACGCGCCTGCGCCTGCAGACCATGACCCTCGAGCACGTGCTGCGCTTCCTGCGCCGAAACGCCTTCATTCTGCTGACGGTCAGCGCCGTG
GTCATTGGGGTCAGCCTGGCCTTTGCCCTGCGCCCATATCAGCTCACCTACCGCCAGATCAAGTACTTCTCTTTTCCTGGAGAGCTTCTG
ATGAGGATGCTGCAGATGCTGGTGTTACCTCTCATTGTCTCCAGCCTGGTCACAGAAATATGTTTCCACCAAACCTTGTGGAGGCCTGCT
TCAAACAGTTCAAGACGCAGTACAGCACGAGGGTGGTAACCAGGACCATGGTGAGGACAGAGAACGGGTCTGAGCCGGGTGCCTCCATGC
CTCCTCCATTCTCAGTGGAGAACGGAACCAGCTTCCTGGAAAATGTCACTCGGGCCTTGGGTACCCTGCAGGAGATGCTGAGCTTTGAGG
AGACTGTACCCGTGCCTGGCTCCGCCAATGGCATCAACGCCCTGGGCCTCGTGGTCTTCTCTGTGGCCTTTGGGCTGGTCATTGGTGGCA
TGAAACACAAGGGCAGAGTCCTCAGGGACTTCTTCGACAGCCTCAATGAGGCTATTATGAGGCTGGTGGGCATCATTATCTGGTATGCAC
CTGTGGGCATCCTGTTCCTGATTGCTGGGAAGATTCTGGAGATGGAAGACATGGCCGTCCTGGGGGGTCAGCTGGGCATGTACACCCTGA
CCGTCATCGTGGGCCTGTTCCTCCATGCCGGCATTGTCCTTCCCCTCATCTACTTCCTCGTCACTCACCGGAACCCCTTCCCCTTCATTG
GGGGCATGCTACAAGCCCTCATCACCGCTATGGGCACGTCTTCCAGCTCGGCAACGCTGCCCATCACCTTCCGCTGCCTGGAGGAGGGCC
TGGGTGTGGACCGCCGCATCACCAGGTTCGTCCTGCCCGTGGGCGCCACGGTCAACATGGATGGCACTGCCCTCTACGAGGCCCTGGCTG
CCATCTTCATTGCTCAAGTTAACAACTACGAGCTCAACCTGGGTCAGATCACAACCATCAGCATCACGGCCACAGCAGCCAGTGTTGGGG
CTGCTGGCATCCCCCAGGCGGGTCTGGTCACCATGGTCATTGTGCTTACGTCGGTCGGCTTGCCCACGGAAGACATCACGCTCATCATTG
CCGTGGACTGGTTCCTTGACCGGCTTCGCACAATGACCAACGTACTGGGGGACTCAATTGGAGCGGCCGTCATCGAGCACTTGTCTCAGC
GGGAGCTGGAGCTTCAGGAAGCTGAGCTTACCCTCCCCAGCCTGGGGAAACCCTACAAGTCCCTCATGGCACAGGAGAAGGGGGCATCCC
GGGGACGGGGAGGCAACGAGAGTGCTATGTGAGGGGCCTCCAGCTCTGCCCCCCCAGAGAGGAGGGAAGGGGGCTGGGGAGGGGAGTCCT
GGTGACACATCTGTTGCCCAACTGACCGTGGGCTGAACACACGTTCTGCTTGACTCATTTAGGGGGGAGGGAAAAGTGAAATAAAGGAGC

>52750_52750_2_MED26-SLC1A6_MED26_chr19_16738682_ENST00000263390_SLC1A6_chr19_15083730_ENST00000430939_length(amino acids)=522AA_BP=24
MTAAPASPQQIRDRLLQAIDPQSNIDHEQPWQQPVPAGERPAAGPGGLAAAAAGKPAAESTAHAPAPADHDPRARAALPAPKRLHSADGQ
RRGHWGQPGLCPAPISAHLPPDQVLLFSWRASDEDAADAGVTSHCLQPGHRNMFPPNLVEACFKQFKTQYSTRVVTRTMVRTENGSEPGA
SMPPPFSVENGTSFLENVTRALGTLQEMLSFEETVPVPGSANGINALGLVVFSVAFGLVIGGMKHKGRVLRDFFDSLNEAIMRLVGIIIW
YAPVGILFLIAGKILEMEDMAVLGGQLGMYTLTVIVGLFLHAGIVLPLIYFLVTHRNPFPFIGGMLQALITAMGTSSSSATLPITFRCLE
EGLGVDRRITRFVLPVGATVNMDGTALYEALAAIFIAQVNNYELNLGQITTISITATAASVGAAGIPQAGLVTMVIVLTSVGLPTEDITL

--------------------------------------------------------------
>52750_52750_3_MED26-SLC1A6_MED26_chr19_16738683_ENST00000263390_SLC1A6_chr19_15083729_ENST00000221742_length(transcript)=2054nt_BP=335nt
TCACTGGAGTTTGGTTCTCGAGGCGGCGGCAGCGAGCGGCGGCGGCTCCGGCGGCTCCTCCTCCTCCTTTGGTGGCGGCGGCGGCCCGGG
ACCGAGACCCGGCCCCGGCTCCCCTCTCCGCCACCCCGCGCGCCCCCAACCCCCCGGCGCCGCGGGGAACATGCGGCTCCGGCTCCCGGA
GGCCGGCGAGTGAGTGACCCCCGTCCCCCGCCTCAGCCCGCCCGCCCGCTGGCCCGGCCGCAACCCCCCGCCTCGCCCAGGCAATGACAG
CGGCTCCGGCGTCTCCGCAGCAGATCAGGGACCGGCTGCTGCAGGCCATCGACCCCCAGAGCAACGATAGACCATGAGCAGCCATGGCAA
CAGCCTGTTCCTGCGGGAGAGCGGCCAGCGGCTGGGCCGGGTGGGCTGGCTGCAGCGGCTGCAGGAAAGCCTGCAGCAGAGAGCACTGCG
CACGCGCCTGCGCCTGCAGACCATGACCCTCGAGCACGTGCTGCGCTTCCTGCGCCGAAACGCCTTCATTCTGCTGACGGTCAGCGCCGT
GGTCATTGGGGTCAGCCTGGCCTTTGCCCTGCGCCCATATCAGCTCACCTACCGCCAGATCAAGTACTTCTCTTTTCCTGGAGAGCTTCT
GATGAGGATGCTGCAGATGCTGGTGTTACCTCTCATTGTCTCCAGCCTGGTCACAGGTATGGCATCCCTGGACAACAAGGCCACGGGGCG
GATGGGGATGCGGGCAGCTGTGTACTACATGGTGACCACCATCATCGCGGTCTTCATCGGCATCCTCATGGTCACCATCATCCATCCCGG
GAAGGGCTCCAAGGAGGGGCTGCACCGGGAGGGCCGGATCGAGACCATCCCCACAGCTGATGCCTTCATGGACCTGATCAGAAATATGTT
TCCACCAAACCTTGTGGAGGCCTGCTTCAAACAGTTCAAGACGCAGTACAGCACGAGGGTGGTAACCAGGACCATGGTGAGGACAGAGAA
CGGGTCTGAGCCGGGTGCCTCCATGCCTCCTCCATTCTCAGTGGAGAACGGAACCAGCTTCCTGGAAAATGTCACTCGGGCCTTGGGTAC
CCTGCAGGAGATGCTGAGCTTTGAGGAGACTGTACCCGTGCCTGGCTCCGCCAATGGCATCAACGCCCTGGGCCTCGTGGTCTTCTCTGT
GGCCTTTGGGCTGGTCATTGGTGGCATGAAACACAAGGGCAGAGTCCTCAGGGACTTCTTCGACAGCCTCAATGAGGCTATTATGAGGCT
GGTGGGCATCATTATCTGGTATGCACCTGTGGGCATCCTGTTCCTGATTGCTGGGAAGATTCTGGAGATGGAAGACATGGCCGTCCTGGG
GGGTCAGCTGGGCATGTACACCCTGACCGTCATCGTGGGCCTGTTCCTCCATGCCGGCATTGTCCTTCCCCTCATCTACTTCCTCGTCAC
TCACCGGAACCCCTTCCCCTTCATTGGGGGCATGCTACAAGCCCTCATCACCGCTATGGGCACGTCTTCCAGCTCGGCAACGCTGCCCAT
CACCTTCCGCTGCCTGGAGGAGGGCCTGGGTGTGGACCGCCGCATCACCAGGTTCGTCCTGCCCGTGGGCGCCACGGTCAACATGGATGG
CACTGCCCTCTACGAGGCCCTGGCTGCCATCTTCATTGCTCAAGTTAACAACTACGAGCTCAACCTGGGTCAGATCACAACCATCAGCAT
CACGGCCACAGCAGCCAGTGTTGGGGCTGCTGGCATCCCCCAGGCGGGTCTGGTCACCATGGTCATTGTGCTTACGTCGGTCGGCTTGCC
CACGGAAGACATCACGCTCATCATTGCCGTGGACTGGTTCCTTGACCGGCTTCGCACAATGACCAACGTACTGGGGGACTCAATTGGAGC
GGCCGTCATCGAGCACTTGTCTCAGCGGGAGCTGGAGCTTCAGGAAGCTGAGCTTACCCTCCCCAGCCTGGGGAAACCCTACAAGTCCCT

>52750_52750_3_MED26-SLC1A6_MED26_chr19_16738683_ENST00000263390_SLC1A6_chr19_15083729_ENST00000221742_length(amino acids)=564AA_BP=0
MSSHGNSLFLRESGQRLGRVGWLQRLQESLQQRALRTRLRLQTMTLEHVLRFLRRNAFILLTVSAVVIGVSLAFALRPYQLTYRQIKYFS
FPGELLMRMLQMLVLPLIVSSLVTGMASLDNKATGRMGMRAAVYYMVTTIIAVFIGILMVTIIHPGKGSKEGLHREGRIETIPTADAFMD
LIRNMFPPNLVEACFKQFKTQYSTRVVTRTMVRTENGSEPGASMPPPFSVENGTSFLENVTRALGTLQEMLSFEETVPVPGSANGINALG
LVVFSVAFGLVIGGMKHKGRVLRDFFDSLNEAIMRLVGIIIWYAPVGILFLIAGKILEMEDMAVLGGQLGMYTLTVIVGLFLHAGIVLPL
IYFLVTHRNPFPFIGGMLQALITAMGTSSSSATLPITFRCLEEGLGVDRRITRFVLPVGATVNMDGTALYEALAAIFIAQVNNYELNLGQ
ITTISITATAASVGAAGIPQAGLVTMVIVLTSVGLPTEDITLIIAVDWFLDRLRTMTNVLGDSIGAAVIEHLSQRELELQEAELTLPSLG

--------------------------------------------------------------
>52750_52750_4_MED26-SLC1A6_MED26_chr19_16738683_ENST00000263390_SLC1A6_chr19_15083729_ENST00000430939_length(transcript)=1993nt_BP=335nt
TCACTGGAGTTTGGTTCTCGAGGCGGCGGCAGCGAGCGGCGGCGGCTCCGGCGGCTCCTCCTCCTCCTTTGGTGGCGGCGGCGGCCCGGG
ACCGAGACCCGGCCCCGGCTCCCCTCTCCGCCACCCCGCGCGCCCCCAACCCCCCGGCGCCGCGGGGAACATGCGGCTCCGGCTCCCGGA
GGCCGGCGAGTGAGTGACCCCCGTCCCCCGCCTCAGCCCGCCCGCCCGCTGGCCCGGCCGCAACCCCCCGCCTCGCCCAGGCAATGACAG
CGGCTCCGGCGTCTCCGCAGCAGATCAGGGACCGGCTGCTGCAGGCCATCGACCCCCAGAGCAACATAGACCATGAGCAGCCATGGCAAC
AGCCTGTTCCTGCGGGAGAGCGGCCAGCGGCTGGGCCGGGTGGGCTGGCTGCAGCGGCTGCAGGAAAGCCTGCAGCAGAGAGCACTGCGC
ACGCGCCTGCGCCTGCAGACCATGACCCTCGAGCACGTGCTGCGCTTCCTGCGCCGAAACGCCTTCATTCTGCTGACGGTCAGCGCCGTG
GTCATTGGGGTCAGCCTGGCCTTTGCCCTGCGCCCATATCAGCTCACCTACCGCCAGATCAAGTACTTCTCTTTTCCTGGAGAGCTTCTG
ATGAGGATGCTGCAGATGCTGGTGTTACCTCTCATTGTCTCCAGCCTGGTCACAGAAATATGTTTCCACCAAACCTTGTGGAGGCCTGCT
TCAAACAGTTCAAGACGCAGTACAGCACGAGGGTGGTAACCAGGACCATGGTGAGGACAGAGAACGGGTCTGAGCCGGGTGCCTCCATGC
CTCCTCCATTCTCAGTGGAGAACGGAACCAGCTTCCTGGAAAATGTCACTCGGGCCTTGGGTACCCTGCAGGAGATGCTGAGCTTTGAGG
AGACTGTACCCGTGCCTGGCTCCGCCAATGGCATCAACGCCCTGGGCCTCGTGGTCTTCTCTGTGGCCTTTGGGCTGGTCATTGGTGGCA
TGAAACACAAGGGCAGAGTCCTCAGGGACTTCTTCGACAGCCTCAATGAGGCTATTATGAGGCTGGTGGGCATCATTATCTGGTATGCAC
CTGTGGGCATCCTGTTCCTGATTGCTGGGAAGATTCTGGAGATGGAAGACATGGCCGTCCTGGGGGGTCAGCTGGGCATGTACACCCTGA
CCGTCATCGTGGGCCTGTTCCTCCATGCCGGCATTGTCCTTCCCCTCATCTACTTCCTCGTCACTCACCGGAACCCCTTCCCCTTCATTG
GGGGCATGCTACAAGCCCTCATCACCGCTATGGGCACGTCTTCCAGCTCGGCAACGCTGCCCATCACCTTCCGCTGCCTGGAGGAGGGCC
TGGGTGTGGACCGCCGCATCACCAGGTTCGTCCTGCCCGTGGGCGCCACGGTCAACATGGATGGCACTGCCCTCTACGAGGCCCTGGCTG
CCATCTTCATTGCTCAAGTTAACAACTACGAGCTCAACCTGGGTCAGATCACAACCATCAGCATCACGGCCACAGCAGCCAGTGTTGGGG
CTGCTGGCATCCCCCAGGCGGGTCTGGTCACCATGGTCATTGTGCTTACGTCGGTCGGCTTGCCCACGGAAGACATCACGCTCATCATTG
CCGTGGACTGGTTCCTTGACCGGCTTCGCACAATGACCAACGTACTGGGGGACTCAATTGGAGCGGCCGTCATCGAGCACTTGTCTCAGC
GGGAGCTGGAGCTTCAGGAAGCTGAGCTTACCCTCCCCAGCCTGGGGAAACCCTACAAGTCCCTCATGGCACAGGAGAAGGGGGCATCCC
GGGGACGGGGAGGCAACGAGAGTGCTATGTGAGGGGCCTCCAGCTCTGCCCCCCCAGAGAGGAGGGAAGGGGGCTGGGGAGGGGAGTCCT
GGTGACACATCTGTTGCCCAACTGACCGTGGGCTGAACACACGTTCTGCTTGACTCATTTAGGGGGGAGGGAAAAGTGAAATAAAGGAGC

>52750_52750_4_MED26-SLC1A6_MED26_chr19_16738683_ENST00000263390_SLC1A6_chr19_15083729_ENST00000430939_length(amino acids)=522AA_BP=24
MTAAPASPQQIRDRLLQAIDPQSNIDHEQPWQQPVPAGERPAAGPGGLAAAAAGKPAAESTAHAPAPADHDPRARAALPAPKRLHSADGQ
RRGHWGQPGLCPAPISAHLPPDQVLLFSWRASDEDAADAGVTSHCLQPGHRNMFPPNLVEACFKQFKTQYSTRVVTRTMVRTENGSEPGA
SMPPPFSVENGTSFLENVTRALGTLQEMLSFEETVPVPGSANGINALGLVVFSVAFGLVIGGMKHKGRVLRDFFDSLNEAIMRLVGIIIW
YAPVGILFLIAGKILEMEDMAVLGGQLGMYTLTVIVGLFLHAGIVLPLIYFLVTHRNPFPFIGGMLQALITAMGTSSSSATLPITFRCLE
EGLGVDRRITRFVLPVGATVNMDGTALYEALAAIFIAQVNNYELNLGQITTISITATAASVGAAGIPQAGLVTMVIVLTSVGLPTEDITL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MED26-SLC1A6

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for MED26-SLC1A6

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for MED26-SLC1A6

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source