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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MED4-HTR2A (FusionGDB2 ID:52779)

Fusion Gene Summary for MED4-HTR2A

check button Fusion gene summary
Fusion gene informationFusion gene name: MED4-HTR2A
Fusion gene ID: 52779
HgeneTgene
Gene symbol

MED4

HTR2A

Gene ID

29079

3356

Gene namemediator complex subunit 45-hydroxytryptamine receptor 2A
SynonymsARC36|DRIP36|HSPC126|TRAP36|VDRIP5-HT2A|HTR2
Cytomap

13q14.2

13q14.2

Type of geneprotein-codingprotein-coding
Descriptionmediator of RNA polymerase II transcription subunit 4TRAP/SMCC/PC2 subunit p36activator-recruited cofactor 36 kDa componentmediator, 34-kD subunit, homologvitamin D receptor-interacting protein, 36-kDvitamin D3 receptor-interacting protein complex 365-hydroxytryptamine receptor 2A5-HT2 receptor5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupledserotonin 5-HT-2A receptor
Modification date2020031320200315
UniProtAcc

Q9NPJ6

.
Ensembl transtripts involved in fusion geneENST00000495013, ENST00000258648, 
ENST00000378586, 		ENST00000378688, 
ENST00000542664, ENST00000543956, 
Fusion gene scores* DoF score6 X 6 X 4=1441 X 1 X 1=1
# samples 61
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: MED4 [Title/Abstract] AND HTR2A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMED4(48653980)-HTR2A(47409774), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMED4

GO:0006366

transcription by RNA polymerase II

10882111

HgeneMED4

GO:0006367

transcription initiation from RNA polymerase II promoter

12218053

HgeneMED4

GO:0045893

positive regulation of transcription, DNA-templated

10198638

TgeneHTR2A

GO:0006874

cellular calcium ion homeostasis

16517693|19057895

TgeneHTR2A

GO:0007202

activation of phospholipase C activity

16517693

TgeneHTR2A

GO:0010513

positive regulation of phosphatidylinositol biosynthetic process

19057895

TgeneHTR2A

GO:0014065

phosphatidylinositol 3-kinase signaling

16517693

TgeneHTR2A

GO:0042493

response to drug

15862800|18703043

TgeneHTR2A

GO:0051209

release of sequestered calcium ion into cytosol

15862800

TgeneHTR2A

GO:0070374

positive regulation of ERK1 and ERK2 cascade

19057895


check buttonFusion gene breakpoints across MED4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HTR2A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-12-0619-01AMED4chr13

48653980

-HTR2Achr13

47409774

-


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Fusion Gene ORF analysis for MED4-HTR2A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000495013ENST00000378688MED4chr13

48653980

-HTR2Achr13

47409774

-
5UTR-3CDSENST00000495013ENST00000542664MED4chr13

48653980

-HTR2Achr13

47409774

-
5UTR-3CDSENST00000495013ENST00000543956MED4chr13

48653980

-HTR2Achr13

47409774

-
In-frameENST00000258648ENST00000378688MED4chr13

48653980

-HTR2Achr13

47409774

-
In-frameENST00000258648ENST00000542664MED4chr13

48653980

-HTR2Achr13

47409774

-
In-frameENST00000258648ENST00000543956MED4chr13

48653980

-HTR2Achr13

47409774

-
In-frameENST00000378586ENST00000378688MED4chr13

48653980

-HTR2Achr13

47409774

-
In-frameENST00000378586ENST00000542664MED4chr13

48653980

-HTR2Achr13

47409774

-
In-frameENST00000378586ENST00000543956MED4chr13

48653980

-HTR2Achr13

47409774

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000258648MED4chr1348653980-ENST00000378688HTR2Achr1347409774-4756666171468483
ENST00000258648MED4chr1348653980-ENST00000542664HTR2Achr1347409774-2928666171468483
ENST00000258648MED4chr1348653980-ENST00000543956HTR2Achr1347409774-2928666171468483
ENST00000378586MED4chr1348653980-ENST00000378688HTR2Achr1347409774-467758741389461
ENST00000378586MED4chr1348653980-ENST00000542664HTR2Achr1347409774-284958741389461
ENST00000378586MED4chr1348653980-ENST00000543956HTR2Achr1347409774-284958741389461

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000258648ENST00000378688MED4chr1348653980-HTR2Achr1347409774-0.000582380.99941766
ENST00000258648ENST00000542664MED4chr1348653980-HTR2Achr1347409774-0.0011480960.9988519
ENST00000258648ENST00000543956MED4chr1348653980-HTR2Achr1347409774-0.0011480960.9988519
ENST00000378586ENST00000378688MED4chr1348653980-HTR2Achr1347409774-0.0003438320.9996562
ENST00000378586ENST00000542664MED4chr1348653980-HTR2Achr1347409774-0.0007937120.99920636
ENST00000378586ENST00000543956MED4chr1348653980-HTR2Achr1347409774-0.0007937120.99920636

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Fusion Genomic Features for MED4-HTR2A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MED4-HTR2A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:48653980/chr13:47409774)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MED4

Q9NPJ6

.
FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMED4chr13:48653980chr13:47409774ENST00000258648-6724_48213271.0Coiled coilOntology_term=ECO:0000255
HgeneMED4chr13:48653980chr13:47409774ENST00000258648-6790_131213271.0Coiled coilOntology_term=ECO:0000255
HgeneMED4chr13:48653980chr13:47409774ENST00000378586-6724_48167225.0Coiled coilOntology_term=ECO:0000255
HgeneMED4chr13:48653980chr13:47409774ENST00000378586-6790_131167225.0Coiled coilOntology_term=ECO:0000255
TgeneHTR2Achr13:48653980chr13:47409774ENST0000037868813376_380204472.0MotifNPxxY motif%3B important for ligand-induced conformation changes and signaling
TgeneHTR2Achr13:48653980chr13:47409774ENST0000037868813469_471204472.0MotifPDZ-binding
TgeneHTR2Achr13:48653980chr13:47409774ENST0000054266424376_380204472.0MotifNPxxY motif%3B important for ligand-induced conformation changes and signaling
TgeneHTR2Achr13:48653980chr13:47409774ENST0000054266424469_471204472.0MotifPDZ-binding
TgeneHTR2Achr13:48653980chr13:47409774ENST0000054395613172_174120388.0MotifDRY motif%3B important for ligand-induced conformation changes
TgeneHTR2Achr13:48653980chr13:47409774ENST0000054395613376_380120388.0MotifNPxxY motif%3B important for ligand-induced conformation changes and signaling
TgeneHTR2Achr13:48653980chr13:47409774ENST0000054395613469_471120388.0MotifPDZ-binding
TgeneHTR2Achr13:48653980chr13:47409774ENST0000037868813336_340204472.0RegionAgonist binding
TgeneHTR2Achr13:48653980chr13:47409774ENST0000054266424336_340204472.0RegionAgonist binding
TgeneHTR2Achr13:48653980chr13:47409774ENST0000054395613155_160120388.0RegionAgonist binding
TgeneHTR2Achr13:48653980chr13:47409774ENST0000054395613336_340120388.0RegionAgonist binding
TgeneHTR2Achr13:48653980chr13:47409774ENST0000037868813216_233204472.0Topological domainExtracellular
TgeneHTR2Achr13:48653980chr13:47409774ENST0000037868813255_324204472.0Topological domainCytoplasmic
TgeneHTR2Achr13:48653980chr13:47409774ENST0000037868813347_362204472.0Topological domainExtracellular
TgeneHTR2Achr13:48653980chr13:47409774ENST0000037868813385_471204472.0Topological domainCytoplasmic
TgeneHTR2Achr13:48653980chr13:47409774ENST0000054266424216_233204472.0Topological domainExtracellular
TgeneHTR2Achr13:48653980chr13:47409774ENST0000054266424255_324204472.0Topological domainCytoplasmic
TgeneHTR2Achr13:48653980chr13:47409774ENST0000054266424347_362204472.0Topological domainExtracellular
TgeneHTR2Achr13:48653980chr13:47409774ENST0000054266424385_471204472.0Topological domainCytoplasmic
TgeneHTR2Achr13:48653980chr13:47409774ENST0000054395613133_148120388.0Topological domainExtracellular
TgeneHTR2Achr13:48653980chr13:47409774ENST0000054395613172_191120388.0Topological domainCytoplasmic
TgeneHTR2Achr13:48653980chr13:47409774ENST0000054395613216_233120388.0Topological domainExtracellular
TgeneHTR2Achr13:48653980chr13:47409774ENST0000054395613255_324120388.0Topological domainCytoplasmic
TgeneHTR2Achr13:48653980chr13:47409774ENST0000054395613347_362120388.0Topological domainExtracellular
TgeneHTR2Achr13:48653980chr13:47409774ENST0000054395613385_471120388.0Topological domainCytoplasmic
TgeneHTR2Achr13:48653980chr13:47409774ENST0000037868813234_254204472.0TransmembraneHelical%3B Name%3D5
TgeneHTR2Achr13:48653980chr13:47409774ENST0000037868813325_346204472.0TransmembraneHelical%3B Name%3D6
TgeneHTR2Achr13:48653980chr13:47409774ENST0000037868813363_384204472.0TransmembraneHelical%3B Name%3D7
TgeneHTR2Achr13:48653980chr13:47409774ENST0000054266424234_254204472.0TransmembraneHelical%3B Name%3D5
TgeneHTR2Achr13:48653980chr13:47409774ENST0000054266424325_346204472.0TransmembraneHelical%3B Name%3D6
TgeneHTR2Achr13:48653980chr13:47409774ENST0000054266424363_384204472.0TransmembraneHelical%3B Name%3D7
TgeneHTR2Achr13:48653980chr13:47409774ENST0000054395613149_171120388.0TransmembraneHelical%3B Name%3D3
TgeneHTR2Achr13:48653980chr13:47409774ENST0000054395613192_215120388.0TransmembraneHelical%3B Name%3D4
TgeneHTR2Achr13:48653980chr13:47409774ENST0000054395613234_254120388.0TransmembraneHelical%3B Name%3D5
TgeneHTR2Achr13:48653980chr13:47409774ENST0000054395613325_346120388.0TransmembraneHelical%3B Name%3D6
TgeneHTR2Achr13:48653980chr13:47409774ENST0000054395613363_384120388.0TransmembraneHelical%3B Name%3D7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMED4chr13:48653980chr13:47409774ENST00000258648-67262_269213271.0Compositional biasNote=Poly-Ser
HgeneMED4chr13:48653980chr13:47409774ENST00000378586-67262_269167225.0Compositional biasNote=Poly-Ser
TgeneHTR2Achr13:48653980chr13:47409774ENST0000037868813172_174204472.0MotifDRY motif%3B important for ligand-induced conformation changes
TgeneHTR2Achr13:48653980chr13:47409774ENST0000054266424172_174204472.0MotifDRY motif%3B important for ligand-induced conformation changes
TgeneHTR2Achr13:48653980chr13:47409774ENST0000037868813155_160204472.0RegionAgonist binding
TgeneHTR2Achr13:48653980chr13:47409774ENST0000054266424155_160204472.0RegionAgonist binding
TgeneHTR2Achr13:48653980chr13:47409774ENST0000037868813100_110204472.0Topological domainCytoplasmic
TgeneHTR2Achr13:48653980chr13:47409774ENST0000037868813133_148204472.0Topological domainExtracellular
TgeneHTR2Achr13:48653980chr13:47409774ENST0000037868813172_191204472.0Topological domainCytoplasmic
TgeneHTR2Achr13:48653980chr13:47409774ENST00000378688131_75204472.0Topological domainExtracellular
TgeneHTR2Achr13:48653980chr13:47409774ENST0000054266424100_110204472.0Topological domainCytoplasmic
TgeneHTR2Achr13:48653980chr13:47409774ENST0000054266424133_148204472.0Topological domainExtracellular
TgeneHTR2Achr13:48653980chr13:47409774ENST0000054266424172_191204472.0Topological domainCytoplasmic
TgeneHTR2Achr13:48653980chr13:47409774ENST00000542664241_75204472.0Topological domainExtracellular
TgeneHTR2Achr13:48653980chr13:47409774ENST0000054395613100_110120388.0Topological domainCytoplasmic
TgeneHTR2Achr13:48653980chr13:47409774ENST00000543956131_75120388.0Topological domainExtracellular
TgeneHTR2Achr13:48653980chr13:47409774ENST0000037868813111_132204472.0TransmembraneHelical%3B Name%3D2
TgeneHTR2Achr13:48653980chr13:47409774ENST0000037868813149_171204472.0TransmembraneHelical%3B Name%3D3
TgeneHTR2Achr13:48653980chr13:47409774ENST0000037868813192_215204472.0TransmembraneHelical%3B Name%3D4
TgeneHTR2Achr13:48653980chr13:47409774ENST000003786881376_99204472.0TransmembraneHelical%3B Name%3D1
TgeneHTR2Achr13:48653980chr13:47409774ENST0000054266424111_132204472.0TransmembraneHelical%3B Name%3D2
TgeneHTR2Achr13:48653980chr13:47409774ENST0000054266424149_171204472.0TransmembraneHelical%3B Name%3D3
TgeneHTR2Achr13:48653980chr13:47409774ENST0000054266424192_215204472.0TransmembraneHelical%3B Name%3D4
TgeneHTR2Achr13:48653980chr13:47409774ENST000005426642476_99204472.0TransmembraneHelical%3B Name%3D1
TgeneHTR2Achr13:48653980chr13:47409774ENST0000054395613111_132120388.0TransmembraneHelical%3B Name%3D2
TgeneHTR2Achr13:48653980chr13:47409774ENST000005439561376_99120388.0TransmembraneHelical%3B Name%3D1


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Fusion Gene Sequence for MED4-HTR2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>52779_52779_1_MED4-HTR2A_MED4_chr13_48653980_ENST00000258648_HTR2A_chr13_47409774_ENST00000378688_length(transcript)=4756nt_BP=666nt
GCGCCGGTGGCGGGACTCTGGGGAAAATGGCTGCGTCTTCGAGTGGTGAGAAGGAGAAGGAGCGGCTGGGAGGCGGTTTGGGAGTGGCGG
GTGGTAACAGCACACGAGAGCGGCTGCTGTCTGCGCTTGAGGACTTGGAGGTCCTGTCTAGGGAACTTATAGAAATGCTGGCAATTTCAA
GAAACCAAAAGTTGTTACAGGCTGGAGAGGAAAACCAGGTCCTGGAGTTGTTAATTCACCGAGATGGGGAATTTCAAGAACTAATGAAAT
TGGCACTTAATCAGGGAAAAATTCATCATGAAATGCAAGTTTTAGAAAAAGAAGTAGAGAAGAGAGACAGTGATATTCAGCAGCTACAAA
AACAGCTAAAGGAAGCAGAACAAATACTGGCAACAGCTGTTTACCAAGCGAAGGAGAAACTCAAGTCAATAGAAAAAGCAAGAAAAGGTG
CTATCTCCTCTGAAGAAATAATTAAGTATGCACATAGGATCAGTGCAAGTAATGCTGTATGTGCTCCACTGACCTGGGTTCCAGGGGACC
CCCGGAGACCCTACCCAACTGATTTAGAGATGAGAAGTGGGTTACTGGGTCAGATGAACAATCCTTCCACTAATGGCGTGAATGGCCATT
TACCAGGAGATGCACTTGCAGCAGGAAGATTGCCAGGTATATCCATGCCAATACCAGTCTTTGGGCTACAGGACGATTCGAAGGTCTTTA
AGGAGGGGAGTTGCTTACTCGCCGATGATAACTTTGTCCTGATCGGCTCTTTTGTGTCATTTTTCATTCCCTTAACCATCATGGTGATCA
CCTACTTTCTAACTATCAAGTCACTCCAGAAAGAAGCTACTTTGTGTGTAAGTGATCTTGGCACACGGGCCAAATTAGCTTCTTTCAGCT
TCCTCCCTCAGAGTTCTTTGTCTTCAGAAAAGCTCTTCCAGCGGTCGATCCATAGGGAGCCAGGGTCCTACACAGGCAGGAGGACTATGC
AGTCCATCAGCAATGAGCAAAAGGCATGCAAGGTGCTGGGCATCGTCTTCTTCCTGTTTGTGGTGATGTGGTGCCCTTTCTTCATCACAA
ACATCATGGCCGTCATCTGCAAAGAGTCCTGCAATGAGGATGTCATTGGGGCCCTGCTCAATGTGTTTGTTTGGATCGGTTATCTCTCTT
CAGCAGTCAACCCACTAGTCTACACACTGTTCAACAAGACCTATAGGTCAGCCTTTTCACGGTATATTCAGTGTCAGTACAAGGAAAACA
AAAAACCATTGCAGTTAATTTTAGTGAACACAATACCGGCTTTGGCCTACAAGTCTAGCCAACTTCAAATGGGACAAAAAAAGAATTCAA
AGCAAGATGCCAAGACAACAGATAATGACTGCTCAATGGTTGCTCTAGGAAAGCAGCATTCTGAAGAGGCTTCTAAAGACAATAGCGACG
GAGTGAATGAAAAGGTGAGCTGTGTGTGATAGGCTAGTTGCCGTGGCAACTGTGGAAGGCACACTGAGCAAGTTTTCACCTATCTGGAAA
AAAAAAAATATGAGATTGGAAAAAATTAGACAAGTCTAGTGGAACCAACGATCATATCTGTATGCCTCATTTTATTCTGTCAATGAAAAG
CGGGGTTCAATGCTACAAAATGTGTGCTTGGAAAATGTTCTGACAGCATTTCAGCTGTGAGCTTTCTGATACTTATTTATAACATTGTAA
ATGATATGTCTTTAAAATGATTCACTTTTATTGTATAATTATGAAGCCCTAAGTAAATCTAAATTAACTTCTATTTTCAAGTGGAAACCT
TGCTGCTATGCTGTTCATTGATGACATGGGATTGAGTTGGTTACCTATTGCTGTAAATAAAAATAGCTATAAATAGTGAAAATTTTATTG
AATATAATGGCCTCTTAAAAATTATCTTTAAAACTTACTATGGTATATATTTTGAAAGGAGAAAAAAAAAGCCACTAAGGTCAGTGTTAT
AAAATCTGTATTGCTAAGATAATTAAATGAAATACTTGACAACATTTTTCATTCCTGCTTTTTCATAGATACCATTTTGAAATATTCACA
AGGTTGCTGGCATTTGCTGCATTTCAAGTTAATTCTCAGAAGTGAAAAAGACTTCAAATGTTATTCAATAACTATTGCTGCTTTCTCTTC
TACTTCTTGTGCTTTACTCTGAATTTCCAGTGTGGTCTTGTTTAATATTTGTTCCTCTAGGTAAACTAGCAAAAGGATGATTTAACATTA
CCAAATGCCTTTCTAGCAATTGCTTCTCTAAAACAGCACTATCGAGGTATTTGGTAACTTGCTGTGAAATGACTGCATCATGCATGCACT
CTTTTGAGCAGTAAATGTATATTGATGTAACTGTGTCAGGATTGAGGATGAACTCAGGTTTCCGGCTACTGACAGTGGTAGAGTCCTAGG
ACATCTCTGTAAAAAGCAGGTGACTTTCCTATGACACTCATCAGGTAAACTGATGCTTTCAGATCCATCGGTTTATACTATTTATTAAAA
CCATTCTGCTTGGTTCCACAATCATCTATTGAGTGTACATTTATGTGTGAAGCAAATTTCTAGATATGAGAAATATAAAAATAATTAAAA
CAAAATCCTTGCCTTCAAACGAAATGGCTCGGCCAGGCACGGAGGCTCGTGCATGTAATCCTAGCACTTTGGGAGGCTGAGATGGGAGGA
TCACTTGAGGCCAAGAGTTTGAGACCAACCTGGGTAACAAAGTGAGACCTCCCTGTCTCTACAAAAAAAATCAAAAAATTATCTGATCCT
TGTGGCACACAACTGTGGTCCCAGCTACAGGGGAGGCTGAGACGCAAGGATCACTTGAGCCCAGAAGCTCAAGGCTGCAGTGAGCCAAGT
TCACACCACTGCCATTTCCTCCTGGGCAACAGAGTGAGACCCTATCACAAAAAAAAAGAAAGAAAAAAAGAAAATGACTAAACTGAAATG
GTCTTAGTCAAAAAATATATACAGACTTATTTTTAGAATCATTTCAACTTATTTCCTTCTTACCTGGTTCAGAAACAAGTTTGTTTCAAC
TGTGAGAGTAGTTTTAAAAATAAGTTTTCCTGATTGGTTACCAATAAACACCAAACAAATAAAGGAGGGGGAAAATATCACTTGAGGCTT
AACATTGCAATTAATTTAGAAATACGCACCTCAATCTCAAGCCAGTTTATAACTACCATAGTTTTGAGCAAAATTTTTCTTCTATTTCTC
CAAAAACTCACTCATTTCAGTATTACTCATTGACACTGGGCTCCCTAATAGAAAAGCAGATATTATAATATTTCATTGAAATGGTTACTA
AAGAGAAAAAGAGATTAACAACAGTTAATCCACCTTGATATTATAACACTCAAGGTTAAATTGCATGTTGTTATTAGAATCAATGTTATA
TATATGATTACAATGCTGAAGCATTTCTATTGAATGAGAAATAGTGTTTGCCCTAAACCTTTGGGAAAAAAATACAGATTTGAAAACTAA
AGAATGTGGGAAGTGTCATTGTGTAATTTGGAAATGCATAAAATTCTCATTATGTCCTCATAGATATGTTGAAAGATGGTTCACTGTTTC
AAAGATAGAATGTATAATATGCTGCTAGTACCAAGGCTGCATTTGAACTGAACTACTCCTTATGATATACCATACTAACTGATGAAAATA
TAAATGTTAAAATGTCTCCACTCTAATGTATTTTGCCTTCACTTGTAACTCTGCACATTTCATTATATATTAGGGAAAAGATTACAGATT
CTACCCCCATATACTCAATCTTGATCAGAATGTACATTAATGTTGCCTGATAGATGTCTTTTGACTACCTATATATTACAAATGTGTATG
TGTTTTTTTCTTCCATAAGTATCTATTCAAGTGTATACTGTATAGGCAAATGTGTAGCTGTATATATGTACAGACATGTTCTCATGCACT
TTATTCAATATTTATATATTTATATGGACGAAAAGCAAGTCAATGAAAACACTCAGTATATACACATGTGTGCATGTTTGTATCATGTTT
ATTTAAATGTGAATTCATGTTCTAATATTTCTATGACCTTCCATTGCTGCAAAGCAGATTAAAGTGTAACAAAAATATCAGCTCTTTAAA
TAAACTGGAAATTAATCTAATTTTGTGGAAGAACTTTAAGACAAGTCTATGAGGATGGCGAAAACAATGGTCCACATATATAGTTTCTTG
ATCCTAAATAAAATGGTACCTTTGGGCCCTTTGTTTAGTCTGGCAATTTTCTGACTACTATGGCTTTTTAAACAGACTCACACCTAAGTG
AAACACAGTTGTCAAATGATTTATGGATCTGTGATTAAAGGATTCACTTTTAATGAATACTATTAAAACGGAGTAACAAACCTTGCTCTA
CTTTAAGTTGAATGATAGATTCCTCTATATTCAAAAAAAAGCAATTAACTGCCATAATTAGGGAAAACTGTTTAAAGCATACTGCATTTA
CTTGGCCACAGCGCCATCTCATGGTAATTTTTTAAAGTGCTACCGTAGCCAAATTGAACTAAGTCACTGTACTGCTTTCAGCAAAGGGTG
CTCCTCCCATTTGTGCATCAATGAGACATATTTATAAAGTGCTAAATTATTCTGTGCCATATGTAACAAATACAGTGAAGATTATTTTAT

>52779_52779_1_MED4-HTR2A_MED4_chr13_48653980_ENST00000258648_HTR2A_chr13_47409774_ENST00000378688_length(amino acids)=483AA_BP=1
MGKMAASSSGEKEKERLGGGLGVAGGNSTRERLLSALEDLEVLSRELIEMLAISRNQKLLQAGEENQVLELLIHRDGEFQELMKLALNQG
KIHHEMQVLEKEVEKRDSDIQQLQKQLKEAEQILATAVYQAKEKLKSIEKARKGAISSEEIIKYAHRISASNAVCAPLTWVPGDPRRPYP
TDLEMRSGLLGQMNNPSTNGVNGHLPGDALAAGRLPGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTI
KSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVI
CKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKT

--------------------------------------------------------------
>52779_52779_2_MED4-HTR2A_MED4_chr13_48653980_ENST00000258648_HTR2A_chr13_47409774_ENST00000542664_length(transcript)=2928nt_BP=666nt
GCGCCGGTGGCGGGACTCTGGGGAAAATGGCTGCGTCTTCGAGTGGTGAGAAGGAGAAGGAGCGGCTGGGAGGCGGTTTGGGAGTGGCGG
GTGGTAACAGCACACGAGAGCGGCTGCTGTCTGCGCTTGAGGACTTGGAGGTCCTGTCTAGGGAACTTATAGAAATGCTGGCAATTTCAA
GAAACCAAAAGTTGTTACAGGCTGGAGAGGAAAACCAGGTCCTGGAGTTGTTAATTCACCGAGATGGGGAATTTCAAGAACTAATGAAAT
TGGCACTTAATCAGGGAAAAATTCATCATGAAATGCAAGTTTTAGAAAAAGAAGTAGAGAAGAGAGACAGTGATATTCAGCAGCTACAAA
AACAGCTAAAGGAAGCAGAACAAATACTGGCAACAGCTGTTTACCAAGCGAAGGAGAAACTCAAGTCAATAGAAAAAGCAAGAAAAGGTG
CTATCTCCTCTGAAGAAATAATTAAGTATGCACATAGGATCAGTGCAAGTAATGCTGTATGTGCTCCACTGACCTGGGTTCCAGGGGACC
CCCGGAGACCCTACCCAACTGATTTAGAGATGAGAAGTGGGTTACTGGGTCAGATGAACAATCCTTCCACTAATGGCGTGAATGGCCATT
TACCAGGAGATGCACTTGCAGCAGGAAGATTGCCAGGTATATCCATGCCAATACCAGTCTTTGGGCTACAGGACGATTCGAAGGTCTTTA
AGGAGGGGAGTTGCTTACTCGCCGATGATAACTTTGTCCTGATCGGCTCTTTTGTGTCATTTTTCATTCCCTTAACCATCATGGTGATCA
CCTACTTTCTAACTATCAAGTCACTCCAGAAAGAAGCTACTTTGTGTGTAAGTGATCTTGGCACACGGGCCAAATTAGCTTCTTTCAGCT
TCCTCCCTCAGAGTTCTTTGTCTTCAGAAAAGCTCTTCCAGCGGTCGATCCATAGGGAGCCAGGGTCCTACACAGGCAGGAGGACTATGC
AGTCCATCAGCAATGAGCAAAAGGCATGCAAGGTGCTGGGCATCGTCTTCTTCCTGTTTGTGGTGATGTGGTGCCCTTTCTTCATCACAA
ACATCATGGCCGTCATCTGCAAAGAGTCCTGCAATGAGGATGTCATTGGGGCCCTGCTCAATGTGTTTGTTTGGATCGGTTATCTCTCTT
CAGCAGTCAACCCACTAGTCTACACACTGTTCAACAAGACCTATAGGTCAGCCTTTTCACGGTATATTCAGTGTCAGTACAAGGAAAACA
AAAAACCATTGCAGTTAATTTTAGTGAACACAATACCGGCTTTGGCCTACAAGTCTAGCCAACTTCAAATGGGACAAAAAAAGAATTCAA
AGCAAGATGCCAAGACAACAGATAATGACTGCTCAATGGTTGCTCTAGGAAAGCAGCATTCTGAAGAGGCTTCTAAAGACAATAGCGACG
GAGTGAATGAAAAGGTGAGCTGTGTGTGATAGGCTAGTTGCCGTGGCAACTGTGGAAGGCACACTGAGCAAGTTTTCACCTATCTGGAAA
AAAAAAAATATGAGATTGGAAAAAATTAGACAAGTCTAGTGGAACCAACGATCATATCTGTATGCCTCATTTTATTCTGTCAATGAAAAG
CGGGGTTCAATGCTACAAAATGTGTGCTTGGAAAATGTTCTGACAGCATTTCAGCTGTGAGCTTTCTGATACTTATTTATAACATTGTAA
ATGATATGTCTTTAAAATGATTCACTTTTATTGTATAATTATGAAGCCCTAAGTAAATCTAAATTAACTTCTATTTTCAAGTGGAAACCT
TGCTGCTATGCTGTTCATTGATGACATGGGATTGAGTTGGTTACCTATTGCTGTAAATAAAAATAGCTATAAATAGTGAAAATTTTATTG
AATATAATGGCCTCTTAAAAATTATCTTTAAAACTTACTATGGTATATATTTTGAAAGGAGAAAAAAAAAGCCACTAAGGTCAGTGTTAT
AAAATCTGTATTGCTAAGATAATTAAATGAAATACTTGACAACATTTTTCATTCCTGCTTTTTCATAGATACCATTTTGAAATATTCACA
AGGTTGCTGGCATTTGCTGCATTTCAAGTTAATTCTCAGAAGTGAAAAAGACTTCAAATGTTATTCAATAACTATTGCTGCTTTCTCTTC
TACTTCTTGTGCTTTACTCTGAATTTCCAGTGTGGTCTTGTTTAATATTTGTTCCTCTAGGTAAACTAGCAAAAGGATGATTTAACATTA
CCAAATGCCTTTCTAGCAATTGCTTCTCTAAAACAGCACTATCGAGGTATTTGGTAACTTGCTGTGAAATGACTGCATCATGCATGCACT
CTTTTGAGCAGTAAATGTATATTGATGTAACTGTGTCAGGATTGAGGATGAACTCAGGTTTCCGGCTACTGACAGTGGTAGAGTCCTAGG
ACATCTCTGTAAAAAGCAGGTGACTTTCCTATGACACTCATCAGGTAAACTGATGCTTTCAGATCCATCGGTTTATACTATTTATTAAAA
CCATTCTGCTTGGTTCCACAATCATCTATTGAGTGTACATTTATGTGTGAAGCAAATTTCTAGATATGAGAAATATAAAAATAATTAAAA
CAAAATCCTTGCCTTCAAACGAAATGGCTCGGCCAGGCACGGAGGCTCGTGCATGTAATCCTAGCACTTTGGGAGGCTGAGATGGGAGGA
TCACTTGAGGCCAAGAGTTTGAGACCAACCTGGGTAACAAAGTGAGACCTCCCTGTCTCTACAAAAAAAATCAAAAAATTATCTGATCCT
TGTGGCACACAACTGTGGTCCCAGCTACAGGGGAGGCTGAGACGCAAGGATCACTTGAGCCCAGAAGCTCAAGGCTGCAGTGAGCCAAGT

>52779_52779_2_MED4-HTR2A_MED4_chr13_48653980_ENST00000258648_HTR2A_chr13_47409774_ENST00000542664_length(amino acids)=483AA_BP=1
MGKMAASSSGEKEKERLGGGLGVAGGNSTRERLLSALEDLEVLSRELIEMLAISRNQKLLQAGEENQVLELLIHRDGEFQELMKLALNQG
KIHHEMQVLEKEVEKRDSDIQQLQKQLKEAEQILATAVYQAKEKLKSIEKARKGAISSEEIIKYAHRISASNAVCAPLTWVPGDPRRPYP
TDLEMRSGLLGQMNNPSTNGVNGHLPGDALAAGRLPGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTI
KSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVI
CKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKT

--------------------------------------------------------------
>52779_52779_3_MED4-HTR2A_MED4_chr13_48653980_ENST00000258648_HTR2A_chr13_47409774_ENST00000543956_length(transcript)=2928nt_BP=666nt
GCGCCGGTGGCGGGACTCTGGGGAAAATGGCTGCGTCTTCGAGTGGTGAGAAGGAGAAGGAGCGGCTGGGAGGCGGTTTGGGAGTGGCGG
GTGGTAACAGCACACGAGAGCGGCTGCTGTCTGCGCTTGAGGACTTGGAGGTCCTGTCTAGGGAACTTATAGAAATGCTGGCAATTTCAA
GAAACCAAAAGTTGTTACAGGCTGGAGAGGAAAACCAGGTCCTGGAGTTGTTAATTCACCGAGATGGGGAATTTCAAGAACTAATGAAAT
TGGCACTTAATCAGGGAAAAATTCATCATGAAATGCAAGTTTTAGAAAAAGAAGTAGAGAAGAGAGACAGTGATATTCAGCAGCTACAAA
AACAGCTAAAGGAAGCAGAACAAATACTGGCAACAGCTGTTTACCAAGCGAAGGAGAAACTCAAGTCAATAGAAAAAGCAAGAAAAGGTG
CTATCTCCTCTGAAGAAATAATTAAGTATGCACATAGGATCAGTGCAAGTAATGCTGTATGTGCTCCACTGACCTGGGTTCCAGGGGACC
CCCGGAGACCCTACCCAACTGATTTAGAGATGAGAAGTGGGTTACTGGGTCAGATGAACAATCCTTCCACTAATGGCGTGAATGGCCATT
TACCAGGAGATGCACTTGCAGCAGGAAGATTGCCAGGTATATCCATGCCAATACCAGTCTTTGGGCTACAGGACGATTCGAAGGTCTTTA
AGGAGGGGAGTTGCTTACTCGCCGATGATAACTTTGTCCTGATCGGCTCTTTTGTGTCATTTTTCATTCCCTTAACCATCATGGTGATCA
CCTACTTTCTAACTATCAAGTCACTCCAGAAAGAAGCTACTTTGTGTGTAAGTGATCTTGGCACACGGGCCAAATTAGCTTCTTTCAGCT
TCCTCCCTCAGAGTTCTTTGTCTTCAGAAAAGCTCTTCCAGCGGTCGATCCATAGGGAGCCAGGGTCCTACACAGGCAGGAGGACTATGC
AGTCCATCAGCAATGAGCAAAAGGCATGCAAGGTGCTGGGCATCGTCTTCTTCCTGTTTGTGGTGATGTGGTGCCCTTTCTTCATCACAA
ACATCATGGCCGTCATCTGCAAAGAGTCCTGCAATGAGGATGTCATTGGGGCCCTGCTCAATGTGTTTGTTTGGATCGGTTATCTCTCTT
CAGCAGTCAACCCACTAGTCTACACACTGTTCAACAAGACCTATAGGTCAGCCTTTTCACGGTATATTCAGTGTCAGTACAAGGAAAACA
AAAAACCATTGCAGTTAATTTTAGTGAACACAATACCGGCTTTGGCCTACAAGTCTAGCCAACTTCAAATGGGACAAAAAAAGAATTCAA
AGCAAGATGCCAAGACAACAGATAATGACTGCTCAATGGTTGCTCTAGGAAAGCAGCATTCTGAAGAGGCTTCTAAAGACAATAGCGACG
GAGTGAATGAAAAGGTGAGCTGTGTGTGATAGGCTAGTTGCCGTGGCAACTGTGGAAGGCACACTGAGCAAGTTTTCACCTATCTGGAAA
AAAAAAAATATGAGATTGGAAAAAATTAGACAAGTCTAGTGGAACCAACGATCATATCTGTATGCCTCATTTTATTCTGTCAATGAAAAG
CGGGGTTCAATGCTACAAAATGTGTGCTTGGAAAATGTTCTGACAGCATTTCAGCTGTGAGCTTTCTGATACTTATTTATAACATTGTAA
ATGATATGTCTTTAAAATGATTCACTTTTATTGTATAATTATGAAGCCCTAAGTAAATCTAAATTAACTTCTATTTTCAAGTGGAAACCT
TGCTGCTATGCTGTTCATTGATGACATGGGATTGAGTTGGTTACCTATTGCTGTAAATAAAAATAGCTATAAATAGTGAAAATTTTATTG
AATATAATGGCCTCTTAAAAATTATCTTTAAAACTTACTATGGTATATATTTTGAAAGGAGAAAAAAAAAGCCACTAAGGTCAGTGTTAT
AAAATCTGTATTGCTAAGATAATTAAATGAAATACTTGACAACATTTTTCATTCCTGCTTTTTCATAGATACCATTTTGAAATATTCACA
AGGTTGCTGGCATTTGCTGCATTTCAAGTTAATTCTCAGAAGTGAAAAAGACTTCAAATGTTATTCAATAACTATTGCTGCTTTCTCTTC
TACTTCTTGTGCTTTACTCTGAATTTCCAGTGTGGTCTTGTTTAATATTTGTTCCTCTAGGTAAACTAGCAAAAGGATGATTTAACATTA
CCAAATGCCTTTCTAGCAATTGCTTCTCTAAAACAGCACTATCGAGGTATTTGGTAACTTGCTGTGAAATGACTGCATCATGCATGCACT
CTTTTGAGCAGTAAATGTATATTGATGTAACTGTGTCAGGATTGAGGATGAACTCAGGTTTCCGGCTACTGACAGTGGTAGAGTCCTAGG
ACATCTCTGTAAAAAGCAGGTGACTTTCCTATGACACTCATCAGGTAAACTGATGCTTTCAGATCCATCGGTTTATACTATTTATTAAAA
CCATTCTGCTTGGTTCCACAATCATCTATTGAGTGTACATTTATGTGTGAAGCAAATTTCTAGATATGAGAAATATAAAAATAATTAAAA
CAAAATCCTTGCCTTCAAACGAAATGGCTCGGCCAGGCACGGAGGCTCGTGCATGTAATCCTAGCACTTTGGGAGGCTGAGATGGGAGGA
TCACTTGAGGCCAAGAGTTTGAGACCAACCTGGGTAACAAAGTGAGACCTCCCTGTCTCTACAAAAAAAATCAAAAAATTATCTGATCCT
TGTGGCACACAACTGTGGTCCCAGCTACAGGGGAGGCTGAGACGCAAGGATCACTTGAGCCCAGAAGCTCAAGGCTGCAGTGAGCCAAGT

>52779_52779_3_MED4-HTR2A_MED4_chr13_48653980_ENST00000258648_HTR2A_chr13_47409774_ENST00000543956_length(amino acids)=483AA_BP=1
MGKMAASSSGEKEKERLGGGLGVAGGNSTRERLLSALEDLEVLSRELIEMLAISRNQKLLQAGEENQVLELLIHRDGEFQELMKLALNQG
KIHHEMQVLEKEVEKRDSDIQQLQKQLKEAEQILATAVYQAKEKLKSIEKARKGAISSEEIIKYAHRISASNAVCAPLTWVPGDPRRPYP
TDLEMRSGLLGQMNNPSTNGVNGHLPGDALAAGRLPGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTI
KSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVI
CKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKT

--------------------------------------------------------------
>52779_52779_4_MED4-HTR2A_MED4_chr13_48653980_ENST00000378586_HTR2A_chr13_47409774_ENST00000378688_length(transcript)=4677nt_BP=587nt
GCACCTGCGTCAGCTCGCTCTGCGCGTGCGCCGGTGGCGGGACTCTGGGGAAAATGGCTGCGTCTTCGAGTGGGAACTTATAGAAATGCT
GGCAATTTCAAGAAACCAAAAGTTGTTACAGGCTGGAGAGGAAAACCAGGTCCTGGAGTTGTTAATTCACCGAGATGGGGAATTTCAAGA
ACTAATGAAATTGGCACTTAATCAGGGAAAAATTCATCATGAAATGCAAGTTTTAGAAAAAGAAGTAGAGAAGAGAGACAGTGATATTCA
GCAGCTACAAAAACAGCTAAAGGAAGCAGAACAAATACTGGCAACAGCTGTTTACCAAGCGAAGGAGAAACTCAAGTCAATAGAAAAAGC
AAGAAAAGGTGCTATCTCCTCTGAAGAAATAATTAAGTATGCACATAGGATCAGTGCAAGTAATGCTGTATGTGCTCCACTGACCTGGGT
TCCAGGGGACCCCCGGAGACCCTACCCAACTGATTTAGAGATGAGAAGTGGGTTACTGGGTCAGATGAACAATCCTTCCACTAATGGCGT
GAATGGCCATTTACCAGGAGATGCACTTGCAGCAGGAAGATTGCCAGGTATATCCATGCCAATACCAGTCTTTGGGCTACAGGACGATTC
GAAGGTCTTTAAGGAGGGGAGTTGCTTACTCGCCGATGATAACTTTGTCCTGATCGGCTCTTTTGTGTCATTTTTCATTCCCTTAACCAT
CATGGTGATCACCTACTTTCTAACTATCAAGTCACTCCAGAAAGAAGCTACTTTGTGTGTAAGTGATCTTGGCACACGGGCCAAATTAGC
TTCTTTCAGCTTCCTCCCTCAGAGTTCTTTGTCTTCAGAAAAGCTCTTCCAGCGGTCGATCCATAGGGAGCCAGGGTCCTACACAGGCAG
GAGGACTATGCAGTCCATCAGCAATGAGCAAAAGGCATGCAAGGTGCTGGGCATCGTCTTCTTCCTGTTTGTGGTGATGTGGTGCCCTTT
CTTCATCACAAACATCATGGCCGTCATCTGCAAAGAGTCCTGCAATGAGGATGTCATTGGGGCCCTGCTCAATGTGTTTGTTTGGATCGG
TTATCTCTCTTCAGCAGTCAACCCACTAGTCTACACACTGTTCAACAAGACCTATAGGTCAGCCTTTTCACGGTATATTCAGTGTCAGTA
CAAGGAAAACAAAAAACCATTGCAGTTAATTTTAGTGAACACAATACCGGCTTTGGCCTACAAGTCTAGCCAACTTCAAATGGGACAAAA
AAAGAATTCAAAGCAAGATGCCAAGACAACAGATAATGACTGCTCAATGGTTGCTCTAGGAAAGCAGCATTCTGAAGAGGCTTCTAAAGA
CAATAGCGACGGAGTGAATGAAAAGGTGAGCTGTGTGTGATAGGCTAGTTGCCGTGGCAACTGTGGAAGGCACACTGAGCAAGTTTTCAC
CTATCTGGAAAAAAAAAAATATGAGATTGGAAAAAATTAGACAAGTCTAGTGGAACCAACGATCATATCTGTATGCCTCATTTTATTCTG
TCAATGAAAAGCGGGGTTCAATGCTACAAAATGTGTGCTTGGAAAATGTTCTGACAGCATTTCAGCTGTGAGCTTTCTGATACTTATTTA
TAACATTGTAAATGATATGTCTTTAAAATGATTCACTTTTATTGTATAATTATGAAGCCCTAAGTAAATCTAAATTAACTTCTATTTTCA
AGTGGAAACCTTGCTGCTATGCTGTTCATTGATGACATGGGATTGAGTTGGTTACCTATTGCTGTAAATAAAAATAGCTATAAATAGTGA
AAATTTTATTGAATATAATGGCCTCTTAAAAATTATCTTTAAAACTTACTATGGTATATATTTTGAAAGGAGAAAAAAAAAGCCACTAAG
GTCAGTGTTATAAAATCTGTATTGCTAAGATAATTAAATGAAATACTTGACAACATTTTTCATTCCTGCTTTTTCATAGATACCATTTTG
AAATATTCACAAGGTTGCTGGCATTTGCTGCATTTCAAGTTAATTCTCAGAAGTGAAAAAGACTTCAAATGTTATTCAATAACTATTGCT
GCTTTCTCTTCTACTTCTTGTGCTTTACTCTGAATTTCCAGTGTGGTCTTGTTTAATATTTGTTCCTCTAGGTAAACTAGCAAAAGGATG
ATTTAACATTACCAAATGCCTTTCTAGCAATTGCTTCTCTAAAACAGCACTATCGAGGTATTTGGTAACTTGCTGTGAAATGACTGCATC
ATGCATGCACTCTTTTGAGCAGTAAATGTATATTGATGTAACTGTGTCAGGATTGAGGATGAACTCAGGTTTCCGGCTACTGACAGTGGT
AGAGTCCTAGGACATCTCTGTAAAAAGCAGGTGACTTTCCTATGACACTCATCAGGTAAACTGATGCTTTCAGATCCATCGGTTTATACT
ATTTATTAAAACCATTCTGCTTGGTTCCACAATCATCTATTGAGTGTACATTTATGTGTGAAGCAAATTTCTAGATATGAGAAATATAAA
AATAATTAAAACAAAATCCTTGCCTTCAAACGAAATGGCTCGGCCAGGCACGGAGGCTCGTGCATGTAATCCTAGCACTTTGGGAGGCTG
AGATGGGAGGATCACTTGAGGCCAAGAGTTTGAGACCAACCTGGGTAACAAAGTGAGACCTCCCTGTCTCTACAAAAAAAATCAAAAAAT
TATCTGATCCTTGTGGCACACAACTGTGGTCCCAGCTACAGGGGAGGCTGAGACGCAAGGATCACTTGAGCCCAGAAGCTCAAGGCTGCA
GTGAGCCAAGTTCACACCACTGCCATTTCCTCCTGGGCAACAGAGTGAGACCCTATCACAAAAAAAAAGAAAGAAAAAAAGAAAATGACT
AAACTGAAATGGTCTTAGTCAAAAAATATATACAGACTTATTTTTAGAATCATTTCAACTTATTTCCTTCTTACCTGGTTCAGAAACAAG
TTTGTTTCAACTGTGAGAGTAGTTTTAAAAATAAGTTTTCCTGATTGGTTACCAATAAACACCAAACAAATAAAGGAGGGGGAAAATATC
ACTTGAGGCTTAACATTGCAATTAATTTAGAAATACGCACCTCAATCTCAAGCCAGTTTATAACTACCATAGTTTTGAGCAAAATTTTTC
TTCTATTTCTCCAAAAACTCACTCATTTCAGTATTACTCATTGACACTGGGCTCCCTAATAGAAAAGCAGATATTATAATATTTCATTGA
AATGGTTACTAAAGAGAAAAAGAGATTAACAACAGTTAATCCACCTTGATATTATAACACTCAAGGTTAAATTGCATGTTGTTATTAGAA
TCAATGTTATATATATGATTACAATGCTGAAGCATTTCTATTGAATGAGAAATAGTGTTTGCCCTAAACCTTTGGGAAAAAAATACAGAT
TTGAAAACTAAAGAATGTGGGAAGTGTCATTGTGTAATTTGGAAATGCATAAAATTCTCATTATGTCCTCATAGATATGTTGAAAGATGG
TTCACTGTTTCAAAGATAGAATGTATAATATGCTGCTAGTACCAAGGCTGCATTTGAACTGAACTACTCCTTATGATATACCATACTAAC
TGATGAAAATATAAATGTTAAAATGTCTCCACTCTAATGTATTTTGCCTTCACTTGTAACTCTGCACATTTCATTATATATTAGGGAAAA
GATTACAGATTCTACCCCCATATACTCAATCTTGATCAGAATGTACATTAATGTTGCCTGATAGATGTCTTTTGACTACCTATATATTAC
AAATGTGTATGTGTTTTTTTCTTCCATAAGTATCTATTCAAGTGTATACTGTATAGGCAAATGTGTAGCTGTATATATGTACAGACATGT
TCTCATGCACTTTATTCAATATTTATATATTTATATGGACGAAAAGCAAGTCAATGAAAACACTCAGTATATACACATGTGTGCATGTTT
GTATCATGTTTATTTAAATGTGAATTCATGTTCTAATATTTCTATGACCTTCCATTGCTGCAAAGCAGATTAAAGTGTAACAAAAATATC
AGCTCTTTAAATAAACTGGAAATTAATCTAATTTTGTGGAAGAACTTTAAGACAAGTCTATGAGGATGGCGAAAACAATGGTCCACATAT
ATAGTTTCTTGATCCTAAATAAAATGGTACCTTTGGGCCCTTTGTTTAGTCTGGCAATTTTCTGACTACTATGGCTTTTTAAACAGACTC
ACACCTAAGTGAAACACAGTTGTCAAATGATTTATGGATCTGTGATTAAAGGATTCACTTTTAATGAATACTATTAAAACGGAGTAACAA
ACCTTGCTCTACTTTAAGTTGAATGATAGATTCCTCTATATTCAAAAAAAAGCAATTAACTGCCATAATTAGGGAAAACTGTTTAAAGCA
TACTGCATTTACTTGGCCACAGCGCCATCTCATGGTAATTTTTTAAAGTGCTACCGTAGCCAAATTGAACTAAGTCACTGTACTGCTTTC
AGCAAAGGGTGCTCCTCCCATTTGTGCATCAATGAGACATATTTATAAAGTGCTAAATTATTCTGTGCCATATGTAACAAATACAGTGAA

>52779_52779_4_MED4-HTR2A_MED4_chr13_48653980_ENST00000378586_HTR2A_chr13_47409774_ENST00000378688_length(amino acids)=461AA_BP=1
MRQLALRVRRWRDSGENGCVFEWELIEMLAISRNQKLLQAGEENQVLELLIHRDGEFQELMKLALNQGKIHHEMQVLEKEVEKRDSDIQQ
LQKQLKEAEQILATAVYQAKEKLKSIEKARKGAISSEEIIKYAHRISASNAVCAPLTWVPGDPRRPYPTDLEMRSGLLGQMNNPSTNGVN
GHLPGDALAAGRLPGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLAS
FSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGY
LSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDN

--------------------------------------------------------------
>52779_52779_5_MED4-HTR2A_MED4_chr13_48653980_ENST00000378586_HTR2A_chr13_47409774_ENST00000542664_length(transcript)=2849nt_BP=587nt
GCACCTGCGTCAGCTCGCTCTGCGCGTGCGCCGGTGGCGGGACTCTGGGGAAAATGGCTGCGTCTTCGAGTGGGAACTTATAGAAATGCT
GGCAATTTCAAGAAACCAAAAGTTGTTACAGGCTGGAGAGGAAAACCAGGTCCTGGAGTTGTTAATTCACCGAGATGGGGAATTTCAAGA
ACTAATGAAATTGGCACTTAATCAGGGAAAAATTCATCATGAAATGCAAGTTTTAGAAAAAGAAGTAGAGAAGAGAGACAGTGATATTCA
GCAGCTACAAAAACAGCTAAAGGAAGCAGAACAAATACTGGCAACAGCTGTTTACCAAGCGAAGGAGAAACTCAAGTCAATAGAAAAAGC
AAGAAAAGGTGCTATCTCCTCTGAAGAAATAATTAAGTATGCACATAGGATCAGTGCAAGTAATGCTGTATGTGCTCCACTGACCTGGGT
TCCAGGGGACCCCCGGAGACCCTACCCAACTGATTTAGAGATGAGAAGTGGGTTACTGGGTCAGATGAACAATCCTTCCACTAATGGCGT
GAATGGCCATTTACCAGGAGATGCACTTGCAGCAGGAAGATTGCCAGGTATATCCATGCCAATACCAGTCTTTGGGCTACAGGACGATTC
GAAGGTCTTTAAGGAGGGGAGTTGCTTACTCGCCGATGATAACTTTGTCCTGATCGGCTCTTTTGTGTCATTTTTCATTCCCTTAACCAT
CATGGTGATCACCTACTTTCTAACTATCAAGTCACTCCAGAAAGAAGCTACTTTGTGTGTAAGTGATCTTGGCACACGGGCCAAATTAGC
TTCTTTCAGCTTCCTCCCTCAGAGTTCTTTGTCTTCAGAAAAGCTCTTCCAGCGGTCGATCCATAGGGAGCCAGGGTCCTACACAGGCAG
GAGGACTATGCAGTCCATCAGCAATGAGCAAAAGGCATGCAAGGTGCTGGGCATCGTCTTCTTCCTGTTTGTGGTGATGTGGTGCCCTTT
CTTCATCACAAACATCATGGCCGTCATCTGCAAAGAGTCCTGCAATGAGGATGTCATTGGGGCCCTGCTCAATGTGTTTGTTTGGATCGG
TTATCTCTCTTCAGCAGTCAACCCACTAGTCTACACACTGTTCAACAAGACCTATAGGTCAGCCTTTTCACGGTATATTCAGTGTCAGTA
CAAGGAAAACAAAAAACCATTGCAGTTAATTTTAGTGAACACAATACCGGCTTTGGCCTACAAGTCTAGCCAACTTCAAATGGGACAAAA
AAAGAATTCAAAGCAAGATGCCAAGACAACAGATAATGACTGCTCAATGGTTGCTCTAGGAAAGCAGCATTCTGAAGAGGCTTCTAAAGA
CAATAGCGACGGAGTGAATGAAAAGGTGAGCTGTGTGTGATAGGCTAGTTGCCGTGGCAACTGTGGAAGGCACACTGAGCAAGTTTTCAC
CTATCTGGAAAAAAAAAAATATGAGATTGGAAAAAATTAGACAAGTCTAGTGGAACCAACGATCATATCTGTATGCCTCATTTTATTCTG
TCAATGAAAAGCGGGGTTCAATGCTACAAAATGTGTGCTTGGAAAATGTTCTGACAGCATTTCAGCTGTGAGCTTTCTGATACTTATTTA
TAACATTGTAAATGATATGTCTTTAAAATGATTCACTTTTATTGTATAATTATGAAGCCCTAAGTAAATCTAAATTAACTTCTATTTTCA
AGTGGAAACCTTGCTGCTATGCTGTTCATTGATGACATGGGATTGAGTTGGTTACCTATTGCTGTAAATAAAAATAGCTATAAATAGTGA
AAATTTTATTGAATATAATGGCCTCTTAAAAATTATCTTTAAAACTTACTATGGTATATATTTTGAAAGGAGAAAAAAAAAGCCACTAAG
GTCAGTGTTATAAAATCTGTATTGCTAAGATAATTAAATGAAATACTTGACAACATTTTTCATTCCTGCTTTTTCATAGATACCATTTTG
AAATATTCACAAGGTTGCTGGCATTTGCTGCATTTCAAGTTAATTCTCAGAAGTGAAAAAGACTTCAAATGTTATTCAATAACTATTGCT
GCTTTCTCTTCTACTTCTTGTGCTTTACTCTGAATTTCCAGTGTGGTCTTGTTTAATATTTGTTCCTCTAGGTAAACTAGCAAAAGGATG
ATTTAACATTACCAAATGCCTTTCTAGCAATTGCTTCTCTAAAACAGCACTATCGAGGTATTTGGTAACTTGCTGTGAAATGACTGCATC
ATGCATGCACTCTTTTGAGCAGTAAATGTATATTGATGTAACTGTGTCAGGATTGAGGATGAACTCAGGTTTCCGGCTACTGACAGTGGT
AGAGTCCTAGGACATCTCTGTAAAAAGCAGGTGACTTTCCTATGACACTCATCAGGTAAACTGATGCTTTCAGATCCATCGGTTTATACT
ATTTATTAAAACCATTCTGCTTGGTTCCACAATCATCTATTGAGTGTACATTTATGTGTGAAGCAAATTTCTAGATATGAGAAATATAAA
AATAATTAAAACAAAATCCTTGCCTTCAAACGAAATGGCTCGGCCAGGCACGGAGGCTCGTGCATGTAATCCTAGCACTTTGGGAGGCTG
AGATGGGAGGATCACTTGAGGCCAAGAGTTTGAGACCAACCTGGGTAACAAAGTGAGACCTCCCTGTCTCTACAAAAAAAATCAAAAAAT
TATCTGATCCTTGTGGCACACAACTGTGGTCCCAGCTACAGGGGAGGCTGAGACGCAAGGATCACTTGAGCCCAGAAGCTCAAGGCTGCA

>52779_52779_5_MED4-HTR2A_MED4_chr13_48653980_ENST00000378586_HTR2A_chr13_47409774_ENST00000542664_length(amino acids)=461AA_BP=1
MRQLALRVRRWRDSGENGCVFEWELIEMLAISRNQKLLQAGEENQVLELLIHRDGEFQELMKLALNQGKIHHEMQVLEKEVEKRDSDIQQ
LQKQLKEAEQILATAVYQAKEKLKSIEKARKGAISSEEIIKYAHRISASNAVCAPLTWVPGDPRRPYPTDLEMRSGLLGQMNNPSTNGVN
GHLPGDALAAGRLPGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLAS
FSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGY
LSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDN

--------------------------------------------------------------
>52779_52779_6_MED4-HTR2A_MED4_chr13_48653980_ENST00000378586_HTR2A_chr13_47409774_ENST00000543956_length(transcript)=2849nt_BP=587nt
GCACCTGCGTCAGCTCGCTCTGCGCGTGCGCCGGTGGCGGGACTCTGGGGAAAATGGCTGCGTCTTCGAGTGGGAACTTATAGAAATGCT
GGCAATTTCAAGAAACCAAAAGTTGTTACAGGCTGGAGAGGAAAACCAGGTCCTGGAGTTGTTAATTCACCGAGATGGGGAATTTCAAGA
ACTAATGAAATTGGCACTTAATCAGGGAAAAATTCATCATGAAATGCAAGTTTTAGAAAAAGAAGTAGAGAAGAGAGACAGTGATATTCA
GCAGCTACAAAAACAGCTAAAGGAAGCAGAACAAATACTGGCAACAGCTGTTTACCAAGCGAAGGAGAAACTCAAGTCAATAGAAAAAGC
AAGAAAAGGTGCTATCTCCTCTGAAGAAATAATTAAGTATGCACATAGGATCAGTGCAAGTAATGCTGTATGTGCTCCACTGACCTGGGT
TCCAGGGGACCCCCGGAGACCCTACCCAACTGATTTAGAGATGAGAAGTGGGTTACTGGGTCAGATGAACAATCCTTCCACTAATGGCGT
GAATGGCCATTTACCAGGAGATGCACTTGCAGCAGGAAGATTGCCAGGTATATCCATGCCAATACCAGTCTTTGGGCTACAGGACGATTC
GAAGGTCTTTAAGGAGGGGAGTTGCTTACTCGCCGATGATAACTTTGTCCTGATCGGCTCTTTTGTGTCATTTTTCATTCCCTTAACCAT
CATGGTGATCACCTACTTTCTAACTATCAAGTCACTCCAGAAAGAAGCTACTTTGTGTGTAAGTGATCTTGGCACACGGGCCAAATTAGC
TTCTTTCAGCTTCCTCCCTCAGAGTTCTTTGTCTTCAGAAAAGCTCTTCCAGCGGTCGATCCATAGGGAGCCAGGGTCCTACACAGGCAG
GAGGACTATGCAGTCCATCAGCAATGAGCAAAAGGCATGCAAGGTGCTGGGCATCGTCTTCTTCCTGTTTGTGGTGATGTGGTGCCCTTT
CTTCATCACAAACATCATGGCCGTCATCTGCAAAGAGTCCTGCAATGAGGATGTCATTGGGGCCCTGCTCAATGTGTTTGTTTGGATCGG
TTATCTCTCTTCAGCAGTCAACCCACTAGTCTACACACTGTTCAACAAGACCTATAGGTCAGCCTTTTCACGGTATATTCAGTGTCAGTA
CAAGGAAAACAAAAAACCATTGCAGTTAATTTTAGTGAACACAATACCGGCTTTGGCCTACAAGTCTAGCCAACTTCAAATGGGACAAAA
AAAGAATTCAAAGCAAGATGCCAAGACAACAGATAATGACTGCTCAATGGTTGCTCTAGGAAAGCAGCATTCTGAAGAGGCTTCTAAAGA
CAATAGCGACGGAGTGAATGAAAAGGTGAGCTGTGTGTGATAGGCTAGTTGCCGTGGCAACTGTGGAAGGCACACTGAGCAAGTTTTCAC
CTATCTGGAAAAAAAAAAATATGAGATTGGAAAAAATTAGACAAGTCTAGTGGAACCAACGATCATATCTGTATGCCTCATTTTATTCTG
TCAATGAAAAGCGGGGTTCAATGCTACAAAATGTGTGCTTGGAAAATGTTCTGACAGCATTTCAGCTGTGAGCTTTCTGATACTTATTTA
TAACATTGTAAATGATATGTCTTTAAAATGATTCACTTTTATTGTATAATTATGAAGCCCTAAGTAAATCTAAATTAACTTCTATTTTCA
AGTGGAAACCTTGCTGCTATGCTGTTCATTGATGACATGGGATTGAGTTGGTTACCTATTGCTGTAAATAAAAATAGCTATAAATAGTGA
AAATTTTATTGAATATAATGGCCTCTTAAAAATTATCTTTAAAACTTACTATGGTATATATTTTGAAAGGAGAAAAAAAAAGCCACTAAG
GTCAGTGTTATAAAATCTGTATTGCTAAGATAATTAAATGAAATACTTGACAACATTTTTCATTCCTGCTTTTTCATAGATACCATTTTG
AAATATTCACAAGGTTGCTGGCATTTGCTGCATTTCAAGTTAATTCTCAGAAGTGAAAAAGACTTCAAATGTTATTCAATAACTATTGCT
GCTTTCTCTTCTACTTCTTGTGCTTTACTCTGAATTTCCAGTGTGGTCTTGTTTAATATTTGTTCCTCTAGGTAAACTAGCAAAAGGATG
ATTTAACATTACCAAATGCCTTTCTAGCAATTGCTTCTCTAAAACAGCACTATCGAGGTATTTGGTAACTTGCTGTGAAATGACTGCATC
ATGCATGCACTCTTTTGAGCAGTAAATGTATATTGATGTAACTGTGTCAGGATTGAGGATGAACTCAGGTTTCCGGCTACTGACAGTGGT
AGAGTCCTAGGACATCTCTGTAAAAAGCAGGTGACTTTCCTATGACACTCATCAGGTAAACTGATGCTTTCAGATCCATCGGTTTATACT
ATTTATTAAAACCATTCTGCTTGGTTCCACAATCATCTATTGAGTGTACATTTATGTGTGAAGCAAATTTCTAGATATGAGAAATATAAA
AATAATTAAAACAAAATCCTTGCCTTCAAACGAAATGGCTCGGCCAGGCACGGAGGCTCGTGCATGTAATCCTAGCACTTTGGGAGGCTG
AGATGGGAGGATCACTTGAGGCCAAGAGTTTGAGACCAACCTGGGTAACAAAGTGAGACCTCCCTGTCTCTACAAAAAAAATCAAAAAAT
TATCTGATCCTTGTGGCACACAACTGTGGTCCCAGCTACAGGGGAGGCTGAGACGCAAGGATCACTTGAGCCCAGAAGCTCAAGGCTGCA

>52779_52779_6_MED4-HTR2A_MED4_chr13_48653980_ENST00000378586_HTR2A_chr13_47409774_ENST00000543956_length(amino acids)=461AA_BP=1
MRQLALRVRRWRDSGENGCVFEWELIEMLAISRNQKLLQAGEENQVLELLIHRDGEFQELMKLALNQGKIHHEMQVLEKEVEKRDSDIQQ
LQKQLKEAEQILATAVYQAKEKLKSIEKARKGAISSEEIIKYAHRISASNAVCAPLTWVPGDPRRPYPTDLEMRSGLLGQMNNPSTNGVN
GHLPGDALAAGRLPGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLAS
FSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGY
LSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MED4-HTR2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MED4-HTR2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MED4-HTR2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource