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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MEF2D-CD55 (FusionGDB2 ID:52821)

Fusion Gene Summary for MEF2D-CD55

Fusion gene summary

Fusion gene information	Fusion gene name: MEF2D-CD55
	Fusion gene ID: 52821
		Hgene	Tgene
	Gene symbol	MEF2D	CD55
	Gene ID	4209	1604
	Gene name	myocyte enhancer factor 2D	CD55 molecule (Cromer blood group)
	Synonyms	-	CHAPLE\|CR\|CROM\|DAF\|TC
	Cytomap	1q22	1q32.2
	Type of gene	protein-coding	protein-coding
	Description	myocyte-specific enhancer factor 2DMADS box transcription enhancer factor 2, polypeptide D	complement decay-accelerating factorCD55 antigenCD55 molecule, decay accelerating factor for complement (Cromer blood group)Cromer blood group antigen
	Modification date	20200322	20200313
	UniProtAcc	.	P08174
	Ensembl transtripts involved in fusion gene	ENST00000340875, ENST00000348159, ENST00000353795, ENST00000368240, ENST00000360595, ENST00000464356,	ENST00000367064, ENST00000314754, ENST00000367062, ENST00000367065, ENST00000367067, ENST00000391920, ENST00000465534, ENST00000367063, ENST00000391921,
Fusion gene scores	* DoF score	15 X 14 X 10=2100	10 X 8 X 4=320
	# samples	16	10
	** MAII score	log2(16/2100*10)=-3.71424551766612 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/320*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MEF2D [Title/Abstract] AND CD55 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MEF2D(156470278)-CD55(207532891), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MEF2D	GO:0045944	positive regulation of transcription by RNA polymerase II	20590529
Tgene	CD55	GO:0007204	positive regulation of cytosolic calcium ion concentration	8223854
Tgene	CD55	GO:0030449	regulation of complement activation	25284781
Tgene	CD55	GO:0031664	regulation of lipopolysaccharide-mediated signaling pathway	12731067
Tgene	CD55	GO:0035743	CD4-positive, alpha-beta T cell cytokine production	16818763
Tgene	CD55	GO:0045916	negative regulation of complement activation	6211481
Tgene	CD55	GO:1903659	regulation of complement-dependent cytotoxicity	25284781
Tgene	CD55	GO:2000516	positive regulation of CD4-positive, alpha-beta T cell activation	16818763
Tgene	CD55	GO:2000563	positive regulation of CD4-positive, alpha-beta T cell proliferation	16818763

Fusion gene breakpoints across MEF2D (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CD55 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SARC	TCGA-DX-A7EI-01A	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+

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Fusion Gene ORF analysis for MEF2D-CD55

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000340875	ENST00000367064	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3CDS	ENST00000348159	ENST00000367064	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3CDS	ENST00000353795	ENST00000367064	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3CDS	ENST00000368240	ENST00000367064	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000340875	ENST00000314754	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000340875	ENST00000367062	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000340875	ENST00000367065	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000340875	ENST00000367067	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000340875	ENST00000391920	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000340875	ENST00000465534	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000348159	ENST00000314754	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000348159	ENST00000367062	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000348159	ENST00000367065	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000348159	ENST00000367067	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000348159	ENST00000391920	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000348159	ENST00000465534	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000353795	ENST00000314754	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000353795	ENST00000367062	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000353795	ENST00000367065	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000353795	ENST00000367067	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000353795	ENST00000391920	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000353795	ENST00000465534	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000368240	ENST00000314754	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000368240	ENST00000367062	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000368240	ENST00000367065	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000368240	ENST00000367067	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000368240	ENST00000391920	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-3UTR	ENST00000368240	ENST00000465534	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-intron	ENST00000340875	ENST00000367063	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-intron	ENST00000340875	ENST00000391921	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-intron	ENST00000348159	ENST00000367063	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-intron	ENST00000348159	ENST00000391921	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-intron	ENST00000353795	ENST00000367063	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-intron	ENST00000353795	ENST00000391921	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-intron	ENST00000368240	ENST00000367063	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
5UTR-intron	ENST00000368240	ENST00000391921	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
intron-3CDS	ENST00000360595	ENST00000367064	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
intron-3CDS	ENST00000464356	ENST00000367064	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
intron-3UTR	ENST00000360595	ENST00000314754	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
intron-3UTR	ENST00000360595	ENST00000367062	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
intron-3UTR	ENST00000360595	ENST00000367065	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
intron-3UTR	ENST00000360595	ENST00000367067	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
intron-3UTR	ENST00000360595	ENST00000391920	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
intron-3UTR	ENST00000360595	ENST00000465534	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
intron-3UTR	ENST00000464356	ENST00000314754	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
intron-3UTR	ENST00000464356	ENST00000367062	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
intron-3UTR	ENST00000464356	ENST00000367065	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
intron-3UTR	ENST00000464356	ENST00000367067	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
intron-3UTR	ENST00000464356	ENST00000391920	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
intron-3UTR	ENST00000464356	ENST00000465534	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
intron-intron	ENST00000360595	ENST00000367063	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
intron-intron	ENST00000360595	ENST00000391921	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
intron-intron	ENST00000464356	ENST00000367063	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+
intron-intron	ENST00000464356	ENST00000391921	MEF2D	chr1	156470278	-	CD55	chr1	207532891	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for MEF2D-CD55

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MEF2D-CD55

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:156470278/:207532891)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	CD55 P08174
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade (PubMed:7525274). Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage (PubMed:28657829). {ECO:0000269\|PubMed:7525274, ECO:0000305\|PubMed:28657829}.; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus A21, coxsackieviruses B1, B3 and B5. {ECO:0000269\|PubMed:9151867}.; FUNCTION: (Microbial infection) Acts as a receptor for Human enterovirus 70 and D68 (Probable). {ECO:0000269\|PubMed:8764022}.; FUNCTION: (Microbial infection) Acts as a receptor for Human echoviruses 6, 7, 11, 12, 20 and 21. {ECO:0000269\|PubMed:7525274, ECO:0000305\|PubMed:12409401}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for MEF2D-CD55

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MEF2D-CD55

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for MEF2D-CD55

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for MEF2D-CD55

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source