FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:MEGF11-RPL4 (FusionGDB2 ID:52857)

Fusion Gene Summary for MEGF11-RPL4

check button Fusion gene summary
Fusion gene informationFusion gene name: MEGF11-RPL4
Fusion gene ID: 52857
HgeneTgene
Gene symbol

MEGF11

RPL4

Gene ID

84465

6124

Gene namemultiple EGF like domains 11ribosomal protein L4
Synonyms-L4
Cytomap

15q22.31

15q22.31

Type of geneprotein-codingprotein-coding
Descriptionmultiple epidermal growth factor-like domains protein 11multiple EGF-like domains protein 1160S ribosomal protein L460S ribosomal protein L1large ribosomal subunit protein uL4
Modification date2020031320200327
UniProtAcc

A6BM72

.
Ensembl transtripts involved in fusion geneENST00000288745, ENST00000360698, 
ENST00000395625, ENST00000409699, 
ENST00000422354, ENST00000395614, 
ENST00000478721, 		ENST00000568588, 
ENST00000564517, ENST00000307961, 
Fusion gene scores* DoF score9 X 9 X 2=16216 X 14 X 5=1120
# samples 917
** MAII scorelog2(9/162*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1120*10)=-2.71989208080726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MEGF11 [Title/Abstract] AND RPL4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMEGF11(66273116)-RPL4(66795867), # samples:2
Anticipated loss of major functional domain due to fusion event.MEGF11-RPL4 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
MEGF11-RPL4 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MEGF11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RPL4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-DU-7298-01AMEGF11chr15

66273116

-RPL4chr15

66795867

-
ChimerDB4LGGTCGA-DU-7298MEGF11chr15

66273116

-RPL4chr15

66795867

-


Top

Fusion Gene ORF analysis for MEGF11-RPL4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000288745ENST00000568588MEGF11chr15

66273116

-RPL4chr15

66795867

-
5CDS-5UTRENST00000360698ENST00000568588MEGF11chr15

66273116

-RPL4chr15

66795867

-
5CDS-5UTRENST00000395625ENST00000568588MEGF11chr15

66273116

-RPL4chr15

66795867

-
5CDS-5UTRENST00000409699ENST00000568588MEGF11chr15

66273116

-RPL4chr15

66795867

-
5CDS-5UTRENST00000422354ENST00000568588MEGF11chr15

66273116

-RPL4chr15

66795867

-
5CDS-intronENST00000288745ENST00000564517MEGF11chr15

66273116

-RPL4chr15

66795867

-
5CDS-intronENST00000360698ENST00000564517MEGF11chr15

66273116

-RPL4chr15

66795867

-
5CDS-intronENST00000395625ENST00000564517MEGF11chr15

66273116

-RPL4chr15

66795867

-
5CDS-intronENST00000409699ENST00000564517MEGF11chr15

66273116

-RPL4chr15

66795867

-
5CDS-intronENST00000422354ENST00000564517MEGF11chr15

66273116

-RPL4chr15

66795867

-
5UTR-3CDSENST00000395614ENST00000307961MEGF11chr15

66273116

-RPL4chr15

66795867

-
5UTR-5UTRENST00000395614ENST00000568588MEGF11chr15

66273116

-RPL4chr15

66795867

-
5UTR-intronENST00000395614ENST00000564517MEGF11chr15

66273116

-RPL4chr15

66795867

-
Frame-shiftENST00000288745ENST00000307961MEGF11chr15

66273116

-RPL4chr15

66795867

-
Frame-shiftENST00000360698ENST00000307961MEGF11chr15

66273116

-RPL4chr15

66795867

-
Frame-shiftENST00000409699ENST00000307961MEGF11chr15

66273116

-RPL4chr15

66795867

-
In-frameENST00000395625ENST00000307961MEGF11chr15

66273116

-RPL4chr15

66795867

-
In-frameENST00000422354ENST00000307961MEGF11chr15

66273116

-RPL4chr15

66795867

-
intron-3CDSENST00000478721ENST00000307961MEGF11chr15

66273116

-RPL4chr15

66795867

-
intron-5UTRENST00000478721ENST00000568588MEGF11chr15

66273116

-RPL4chr15

66795867

-
intron-intronENST00000478721ENST00000564517MEGF11chr15

66273116

-RPL4chr15

66795867

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000422354MEGF11chr1566273116-ENST00000307961RPL4chr1566795867-3574903272183718
ENST00000395625MEGF11chr1566273116-ENST00000307961RPL4chr1566795867-34738022502082610

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000422354ENST00000307961MEGF11chr1566273116-RPL4chr1566795867-0.002193880.99780613
ENST00000395625ENST00000307961MEGF11chr1566273116-RPL4chr1566795867-0.0062939320.99370605

Top

Fusion Genomic Features for MEGF11-RPL4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for MEGF11-RPL4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:66273116/chr15:66795867)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MEGF11

A6BM72

.
FUNCTION: May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMEGF11chr15:66273116chr15:66795867ENST00000288745-521143_173179970.0DomainEGF-like 2
HgeneMEGF11chr15:66273116chr15:66795867ENST00000288745-52124_101179970.0DomainEMI
HgeneMEGF11chr15:66273116chr15:66795867ENST00000288745-52195_130179970.0DomainEGF-like 1
HgeneMEGF11chr15:66273116chr15:66795867ENST00000360698-723143_1732541840.6666666666667DomainEGF-like 2
HgeneMEGF11chr15:66273116chr15:66795867ENST00000360698-723181_2162541840.6666666666667DomainEGF-like 3
HgeneMEGF11chr15:66273116chr15:66795867ENST00000360698-72324_1012541840.6666666666667DomainEMI
HgeneMEGF11chr15:66273116chr15:66795867ENST00000360698-72395_1302541840.6666666666667DomainEGF-like 1
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395625-622143_173179970.0DomainEGF-like 2
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395625-62224_101179970.0DomainEMI
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395625-62295_130179970.0DomainEGF-like 1
HgeneMEGF11chr15:66273116chr15:66795867ENST00000409699-723143_1732541045.0DomainEGF-like 2
HgeneMEGF11chr15:66273116chr15:66795867ENST00000409699-723181_2162541045.0DomainEGF-like 3
HgeneMEGF11chr15:66273116chr15:66795867ENST00000409699-72324_1012541045.0DomainEMI
HgeneMEGF11chr15:66273116chr15:66795867ENST00000409699-72395_1302541045.0DomainEGF-like 1
HgeneMEGF11chr15:66273116chr15:66795867ENST00000422354-723143_1732541045.0DomainEGF-like 2
HgeneMEGF11chr15:66273116chr15:66795867ENST00000422354-723181_2162541045.0DomainEGF-like 3
HgeneMEGF11chr15:66273116chr15:66795867ENST00000422354-72324_1012541045.0DomainEMI
HgeneMEGF11chr15:66273116chr15:66795867ENST00000422354-72395_1302541045.0DomainEGF-like 1
TgeneRPL4chr15:66273116chr15:66795867ENST00000307961010364_4271428.0Compositional biasNote=Lys-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMEGF11chr15:66273116chr15:66795867ENST00000288745-521181_216179970.0DomainEGF-like 3
HgeneMEGF11chr15:66273116chr15:66795867ENST00000288745-521224_259179970.0DomainEGF-like 4
HgeneMEGF11chr15:66273116chr15:66795867ENST00000288745-521267_302179970.0DomainEGF-like 5
HgeneMEGF11chr15:66273116chr15:66795867ENST00000288745-521310_345179970.0DomainEGF-like 6
HgeneMEGF11chr15:66273116chr15:66795867ENST00000288745-521399_434179970.0DomainEGF-like 7
HgeneMEGF11chr15:66273116chr15:66795867ENST00000288745-521442_477179970.0DomainEGF-like 8
HgeneMEGF11chr15:66273116chr15:66795867ENST00000288745-521490_520179970.0DomainEGF-like 9
HgeneMEGF11chr15:66273116chr15:66795867ENST00000288745-521571_606179970.0DomainEGF-like 10
HgeneMEGF11chr15:66273116chr15:66795867ENST00000288745-521659_694179970.0DomainEGF-like 11
HgeneMEGF11chr15:66273116chr15:66795867ENST00000288745-521707_737179970.0DomainEGF-like 12
HgeneMEGF11chr15:66273116chr15:66795867ENST00000288745-521750_780179970.0DomainEGF-like 13
HgeneMEGF11chr15:66273116chr15:66795867ENST00000288745-521788_823179970.0DomainEGF-like 14
HgeneMEGF11chr15:66273116chr15:66795867ENST00000360698-723224_2592541840.6666666666667DomainEGF-like 4
HgeneMEGF11chr15:66273116chr15:66795867ENST00000360698-723267_3022541840.6666666666667DomainEGF-like 5
HgeneMEGF11chr15:66273116chr15:66795867ENST00000360698-723310_3452541840.6666666666667DomainEGF-like 6
HgeneMEGF11chr15:66273116chr15:66795867ENST00000360698-723399_4342541840.6666666666667DomainEGF-like 7
HgeneMEGF11chr15:66273116chr15:66795867ENST00000360698-723442_4772541840.6666666666667DomainEGF-like 8
HgeneMEGF11chr15:66273116chr15:66795867ENST00000360698-723490_5202541840.6666666666667DomainEGF-like 9
HgeneMEGF11chr15:66273116chr15:66795867ENST00000360698-723571_6062541840.6666666666667DomainEGF-like 10
HgeneMEGF11chr15:66273116chr15:66795867ENST00000360698-723659_6942541840.6666666666667DomainEGF-like 11
HgeneMEGF11chr15:66273116chr15:66795867ENST00000360698-723707_7372541840.6666666666667DomainEGF-like 12
HgeneMEGF11chr15:66273116chr15:66795867ENST00000360698-723750_7802541840.6666666666667DomainEGF-like 13
HgeneMEGF11chr15:66273116chr15:66795867ENST00000360698-723788_8232541840.6666666666667DomainEGF-like 14
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395614-723143_1730138.0DomainEGF-like 2
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395614-723181_2160138.0DomainEGF-like 3
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395614-723224_2590138.0DomainEGF-like 4
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395614-72324_1010138.0DomainEMI
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395614-723267_3020138.0DomainEGF-like 5
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395614-723310_3450138.0DomainEGF-like 6
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395614-723399_4340138.0DomainEGF-like 7
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395614-723442_4770138.0DomainEGF-like 8
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395614-723490_5200138.0DomainEGF-like 9
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395614-723571_6060138.0DomainEGF-like 10
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395614-723659_6940138.0DomainEGF-like 11
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395614-723707_7370138.0DomainEGF-like 12
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395614-723750_7800138.0DomainEGF-like 13
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395614-723788_8230138.0DomainEGF-like 14
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395614-72395_1300138.0DomainEGF-like 1
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395625-622181_216179970.0DomainEGF-like 3
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395625-622224_259179970.0DomainEGF-like 4
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395625-622267_302179970.0DomainEGF-like 5
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395625-622310_345179970.0DomainEGF-like 6
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395625-622399_434179970.0DomainEGF-like 7
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395625-622442_477179970.0DomainEGF-like 8
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395625-622490_520179970.0DomainEGF-like 9
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395625-622571_606179970.0DomainEGF-like 10
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395625-622659_694179970.0DomainEGF-like 11
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395625-622707_737179970.0DomainEGF-like 12
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395625-622750_780179970.0DomainEGF-like 13
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395625-622788_823179970.0DomainEGF-like 14
HgeneMEGF11chr15:66273116chr15:66795867ENST00000409699-723224_2592541045.0DomainEGF-like 4
HgeneMEGF11chr15:66273116chr15:66795867ENST00000409699-723267_3022541045.0DomainEGF-like 5
HgeneMEGF11chr15:66273116chr15:66795867ENST00000409699-723310_3452541045.0DomainEGF-like 6
HgeneMEGF11chr15:66273116chr15:66795867ENST00000409699-723399_4342541045.0DomainEGF-like 7
HgeneMEGF11chr15:66273116chr15:66795867ENST00000409699-723442_4772541045.0DomainEGF-like 8
HgeneMEGF11chr15:66273116chr15:66795867ENST00000409699-723490_5202541045.0DomainEGF-like 9
HgeneMEGF11chr15:66273116chr15:66795867ENST00000409699-723571_6062541045.0DomainEGF-like 10
HgeneMEGF11chr15:66273116chr15:66795867ENST00000409699-723659_6942541045.0DomainEGF-like 11
HgeneMEGF11chr15:66273116chr15:66795867ENST00000409699-723707_7372541045.0DomainEGF-like 12
HgeneMEGF11chr15:66273116chr15:66795867ENST00000409699-723750_7802541045.0DomainEGF-like 13
HgeneMEGF11chr15:66273116chr15:66795867ENST00000409699-723788_8232541045.0DomainEGF-like 14
HgeneMEGF11chr15:66273116chr15:66795867ENST00000422354-723224_2592541045.0DomainEGF-like 4
HgeneMEGF11chr15:66273116chr15:66795867ENST00000422354-723267_3022541045.0DomainEGF-like 5
HgeneMEGF11chr15:66273116chr15:66795867ENST00000422354-723310_3452541045.0DomainEGF-like 6
HgeneMEGF11chr15:66273116chr15:66795867ENST00000422354-723399_4342541045.0DomainEGF-like 7
HgeneMEGF11chr15:66273116chr15:66795867ENST00000422354-723442_4772541045.0DomainEGF-like 8
HgeneMEGF11chr15:66273116chr15:66795867ENST00000422354-723490_5202541045.0DomainEGF-like 9
HgeneMEGF11chr15:66273116chr15:66795867ENST00000422354-723571_6062541045.0DomainEGF-like 10
HgeneMEGF11chr15:66273116chr15:66795867ENST00000422354-723659_6942541045.0DomainEGF-like 11
HgeneMEGF11chr15:66273116chr15:66795867ENST00000422354-723707_7372541045.0DomainEGF-like 12
HgeneMEGF11chr15:66273116chr15:66795867ENST00000422354-723750_7802541045.0DomainEGF-like 13
HgeneMEGF11chr15:66273116chr15:66795867ENST00000422354-723788_8232541045.0DomainEGF-like 14
HgeneMEGF11chr15:66273116chr15:66795867ENST00000288745-52120_848179970.0Topological domainExtracellular
HgeneMEGF11chr15:66273116chr15:66795867ENST00000288745-521870_1044179970.0Topological domainCytoplasmic
HgeneMEGF11chr15:66273116chr15:66795867ENST00000360698-72320_8482541840.6666666666667Topological domainExtracellular
HgeneMEGF11chr15:66273116chr15:66795867ENST00000360698-723870_10442541840.6666666666667Topological domainCytoplasmic
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395614-72320_8480138.0Topological domainExtracellular
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395614-723870_10440138.0Topological domainCytoplasmic
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395625-62220_848179970.0Topological domainExtracellular
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395625-622870_1044179970.0Topological domainCytoplasmic
HgeneMEGF11chr15:66273116chr15:66795867ENST00000409699-72320_8482541045.0Topological domainExtracellular
HgeneMEGF11chr15:66273116chr15:66795867ENST00000409699-723870_10442541045.0Topological domainCytoplasmic
HgeneMEGF11chr15:66273116chr15:66795867ENST00000422354-72320_8482541045.0Topological domainExtracellular
HgeneMEGF11chr15:66273116chr15:66795867ENST00000422354-723870_10442541045.0Topological domainCytoplasmic
HgeneMEGF11chr15:66273116chr15:66795867ENST00000288745-521849_869179970.0TransmembraneHelical
HgeneMEGF11chr15:66273116chr15:66795867ENST00000360698-723849_8692541840.6666666666667TransmembraneHelical
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395614-723849_8690138.0TransmembraneHelical
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395625-622849_869179970.0TransmembraneHelical
HgeneMEGF11chr15:66273116chr15:66795867ENST00000409699-723849_8692541045.0TransmembraneHelical
HgeneMEGF11chr15:66273116chr15:66795867ENST00000422354-723849_8692541045.0TransmembraneHelical


Top

Fusion Gene Sequence for MEGF11-RPL4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>52857_52857_1_MEGF11-RPL4_MEGF11_chr15_66273116_ENST00000395625_RPL4_chr15_66795867_ENST00000307961_length(transcript)=3473nt_BP=802nt
GCCCGCTGCCCGCCGCCCGGCTCCCGGCTGCTCGCGGCCCCCTGCTCCTGCCTGGCGCTCTGGCCAGGCTCGGGCTCCGGAGGACAGGAC
CGCGCGACTGGCCGGCCGATCCCTGGGCCGGCCGCGGGAGCAGGGCCCGGGATGGTGCTCTCCCTGACGGGGCTCATTGCCTTCTCCTTC
CTGCAAGCCACCCTTGCCCTGAACCCCGAGGACCCCAACGTGTGCAGCCACTGGGAGAGCTATGCTGTGACTGTCCAGGAATCGTATGCA
CACCCCTTCGATCAGATCTATTACACACGATGCACAGACATCCTCAACTGGTTCAAGTGCACCAGGCACCGCCCTGTGTACGGAGGAGTG
TGTGCACGGCCGCTGCGTTTCCCCGGACACCTGCCACTGCGAGCCTGGCTGGGGAGGGCCCGACTGCTCCAGCGGCTGCGACAGCGACCA
CTGGGGGCCCCACTGCAGCAACCGGTGCCAGTGCCAGAACGGCGCCCTGTGTAACCCCATCACAGGCGCCTGCGTGTGCGCCGCCGGCTT
CCGTGGATGGCGCTGCGAGGAGCTCTGCGCACCTGGCACCCACGGCAAGGGATGCCAGCTGCCGTGCCAGTGCCGACACGGTGCCAGCTG
CGACCCCCGCGCCGGCGAGTGCCTCTGCGCACCTGGCTACACCGGCGTCTACTGCGAGGAGCTGTGCCCTCCTGGGAGCCATGGAGCTCA
CTGTGAGCTGCGCTGCCCCTGTCAGAATGGGGGCACCTGCCACCACATCACTGGCGAGTGTGCCTGCCCCCCAGGCTGGACGGCGTGTGC
TCGCCCACTGATATCGGTGTACTCCGAAAAGGGGGAGTCATCTGGCAAAAATGTCACTTTGCCTGCTGTATTCAAGGCTCCTATTCGACC
AGATATTGTGAACTTTGTTCACACCAACTTGCGCAAAAACAACAGACAGCCCTATGCTGTCAGTGAATTAGCAGGTCATCAGACTAGTGC
TGAGTCTTGGGGTACTGGCAGAGCTGTGGCTCGAATTCCCAGAGTTCGAGGTGGTGGGACTCACCGCTCTGGCCAGGGTGCTTTTGGAAA
CATGTGTCGTGGAGGCCGAATGTTTGCACCAACCAAAACCTGGCGCCGTTGGCATCGTAGAGTGAACACAACCCAAAAACGATACGCCAT
CTGTTCTGCCCTGGCTGCCTCAGCCCTACCAGCACTGGTCATGTCTAAAGGTCATCGTATTGAGGAAGTTCCTGAACTTCCTTTGGTAGT
TGAAGATAAAGTTGAAGGCTACAAGAAGACCAAGGAAGCTGTTTTGCTCCTTAAGAAACTTAAAGCCTGGAATGATATCAAAAAGGTCTA
TGCCTCTCAGCGAATGAGAGCTGGCAAAGGCAAAATGAGAAACCGTCGCCGTATCCAGCGCAGGGGCCCGTGCATCATCTATAATGAGGA
TAATGGTATCATCAAGGCCTTCAGAAACATCCCTGGAATTACTCTGCTTAATGTAAGCAAGCTGAACATTTTGAAGCTTGCTCCTGGTGG
GCATGTGGGACGTTTCTGCATTTGGACTGAAAGTGCTTTCCGGAAGTTAGATGAATTGTACGGCACTTGGCGTAAAGCCGCTTCCCTCAA
GAGTAACTACAATCTTCCCATGCACAAGATGATTAATACAGATCTTAGCAGAATCTTGAAAAGCCCAGAGATCCAAAGAGCCCTTCGAGC
ACCACGCAAGAAGATCCATCGCAGAGTCCTAAAGAAGAACCCACTGAAAAACTTGAGAATCATGTTGAAGCTAAACCCATATGCAAAGAC
CATGCGCCGGAACACCATTCTTCGCCAGGCCAGGAATCACAAGCTCCGGGTGGATAAGGCAGCTGCTGCAGCAGCGGCACTACAAGCCAA
ATCAGATGAGAAGGCGGCGGTTGCAGGCAAGAAGCCTGTGGTAGGTAAGAAAGGAAAGAAGGCTGCTGTTGGTGTTAAGAAGCAGAAGAA
GCCTCTGGTGGGAAAAAAGGCAGCAGCTACCAAGAAACCAGCCCCTGAAAAGAAGCCTGCAGAGAAGAAACCTACTACAGAGGAGAAGAA
GCCTGCTGCATAAACTCTTAAATTTGATTATTCCATAAAGGTCAAATCATTTTGGACAGCTTCTTTTGAATAAAGACCTGATTATACAGG
CAGTGAGAAACATGACTTGGTGTGCTCTGTAAAGCTTGGTTAGAATTTTTTTAAAGTGACATTTTGTTGGCCATAATTTAGACTGTTACA
TTTTATATAGTGTGGTATAAAATGGGGCATGGATTTATACTAAGTCCATGGAGTTCAGTGGAAGGGGAATGATTTAAAAAAAGTTGTGGT
TTTCTAAATAATGTGGCTTGAAAAATAGGTGTAACAGGACTTGGTCAGAAACGCAGAGGCTGTTCAAGTTTAGCTCCCCACCAGATGGAA
AATAGGTTAAATTCTGTAAAGATTTAACTTTAACCACAAGAGGGCACAACTGGAGAGCACAATTTTTTTGGTACTGCAGTAAAATTGATT
ACCTCTTGAGAAGTGTTCTTTTTAACCAGCTATAACAATAGAGTTGAGTATTTTCACCCATGGTTTGAAAAAGTGCCAGAAGGCCACACT
GGCCCACATCTGTAATCCCAACACTTTGGGACCCTAAGGTGGGCAGAGCACTTGAGCCAATGAGTTCAAGACCAGCCTGGTCAACATGAT
GAAATCTCGTCTCTACTGAAAATATAAAAAATAGCCAGTCATGGTGCATGCCTGTAACCCCAGCTACTTGGAGGCTGAGGCAAGAGAATC
ACTTGAACCTGGGAGGTGGAGGTTGCAATGAGCCAAGATTGTACCATTGCCCTCCAGCCTGGGCGTCAGAGCAAGACTCTCTGAAAAGTA
CCAGAAGCATTTTTCAGGACTGCCTGTGTGTCTTGGTGATTATGTTAACCAACTGTGTTCAAAAGAAGTACCCATGAAATGCCTCCAGAT
ATAAGGGTGTTTTTTTTTACCCATAAAGCTAAACTGCAAATATTACCCTAGAATTAACCTCTTGTCCTGTGTCAAAAGTCTTGTTTTGCA
TCTGGATTGTTAAACTGTCAGCTTCTCTCTGACAGTCTCGAACTGTCAAGACAGTCTCAGTTCACAGCCAAGGTGATCTGTTAACCCTCC
CCATTTCCAGGGCCAAATCTCAGTTCTTAAGCACGTCGTTTCTTAGCACGGCTTTATTTTCATGCTCTTTATTTCTCTATTTTGTGCAGC
CTTACCCCTTTAAAGTCCACTGTGAGTCCTACCCTGCAGGGCCTCTTAACACAGTAGAGTTCATGTGCTACTGATTTGGTGCCTGCCTTC
AAACACATGTGCAAGTTTTGTGGGGTTAAAGATAGCCACTTGGTGGCACACCACATTGGAAGTGCTGTTCACCCGGTCATTTGAAACGGT

>52857_52857_1_MEGF11-RPL4_MEGF11_chr15_66273116_ENST00000395625_RPL4_chr15_66795867_ENST00000307961_length(amino acids)=610AA_BP=184
MSRNRMHTPSIRSITHDAQTSSTGSSAPGTALCTEECVHGRCVSPDTCHCEPGWGGPDCSSGCDSDHWGPHCSNRCQCQNGALCNPITGA
CVCAAGFRGWRCEELCAPGTHGKGCQLPCQCRHGASCDPRAGECLCAPGYTGVYCEELCPPGSHGAHCELRCPCQNGGTCHHITGECACP
PGWTACARPLISVYSEKGESSGKNVTLPAVFKAPIRPDIVNFVHTNLRKNNRQPYAVSELAGHQTSAESWGTGRAVARIPRVRGGGTHRS
GQGAFGNMCRGGRMFAPTKTWRRWHRRVNTTQKRYAICSALAASALPALVMSKGHRIEEVPELPLVVEDKVEGYKKTKEAVLLLKKLKAW
NDIKKVYASQRMRAGKGKMRNRRRIQRRGPCIIYNEDNGIIKAFRNIPGITLLNVSKLNILKLAPGGHVGRFCIWTESAFRKLDELYGTW
RKAASLKSNYNLPMHKMINTDLSRILKSPEIQRALRAPRKKIHRRVLKKNPLKNLRIMLKLNPYAKTMRRNTILRQARNHKLRVDKAAAA

--------------------------------------------------------------
>52857_52857_2_MEGF11-RPL4_MEGF11_chr15_66273116_ENST00000422354_RPL4_chr15_66795867_ENST00000307961_length(transcript)=3574nt_BP=903nt
GCCCGCTGCCCGCCGCCCGGCTCCCGGCTGCTCGCGGCCCCCTGCTCCTGCCTGGCGCTCTGGCCAGGCTCGGGCTCCGGAGGACAGGAC
CGCGCGACTGGCCGGCCGATCCCTGGGCCGGCCGCGGGAGCAGGGCCCGGGATGGTGCTCTCCCTGACGGGGCTCATTGCCTTCTCCTTC
CTGCAAGCCACCCTTGCCCTGAACCCCGAGGACCCCAACGTGTGCAGCCACTGGGAGAGCTATGCTGTGACTGTCCAGGAATCGTATGCA
CACCCCTTCGATCAGATCTATTACACACGATGCACAGACATCCTCAACTGGTTCAAGTGCACCAGGCACCGGATCAGTTATAAGACGGCG
TATCGGAGAGGCCTCCGGACCATGTACCGGCGGAGGTCCCAGTGCTGCCCTGGCTACTATGAGAGCGGAGACTTCTGCATACCCCTGTGT
ACGGAGGAGTGTGTGCACGGCCGCTGCGTTTCCCCGGACACCTGCCACTGCGAGCCTGGCTGGGGAGGGCCCGACTGCTCCAGCGGCTGC
GACAGCGACCACTGGGGGCCCCACTGCAGCAACCGGTGCCAGTGCCAGAACGGCGCCCTGTGTAACCCCATCACAGGCGCCTGCGTGTGC
GCCGCCGGCTTCCGTGGATGGCGCTGCGAGGAGCTCTGCGCACCTGGCACCCACGGCAAGGGATGCCAGCTGCCGTGCCAGTGCCGACAC
GGTGCCAGCTGCGACCCCCGCGCCGGCGAGTGCCTCTGCGCACCTGGCTACACCGGCGTCTACTGCGAGGAGCTGTGCCCTCCTGGGAGC
CATGGAGCTCACTGTGAGCTGCGCTGCCCCTGTCAGAATGGGGGCACCTGCCACCACATCACTGGCGAGTGTGCCTGCCCCCCAGGCTGG
ACGGCGTGTGCTCGCCCACTGATATCGGTGTACTCCGAAAAGGGGGAGTCATCTGGCAAAAATGTCACTTTGCCTGCTGTATTCAAGGCT
CCTATTCGACCAGATATTGTGAACTTTGTTCACACCAACTTGCGCAAAAACAACAGACAGCCCTATGCTGTCAGTGAATTAGCAGGTCAT
CAGACTAGTGCTGAGTCTTGGGGTACTGGCAGAGCTGTGGCTCGAATTCCCAGAGTTCGAGGTGGTGGGACTCACCGCTCTGGCCAGGGT
GCTTTTGGAAACATGTGTCGTGGAGGCCGAATGTTTGCACCAACCAAAACCTGGCGCCGTTGGCATCGTAGAGTGAACACAACCCAAAAA
CGATACGCCATCTGTTCTGCCCTGGCTGCCTCAGCCCTACCAGCACTGGTCATGTCTAAAGGTCATCGTATTGAGGAAGTTCCTGAACTT
CCTTTGGTAGTTGAAGATAAAGTTGAAGGCTACAAGAAGACCAAGGAAGCTGTTTTGCTCCTTAAGAAACTTAAAGCCTGGAATGATATC
AAAAAGGTCTATGCCTCTCAGCGAATGAGAGCTGGCAAAGGCAAAATGAGAAACCGTCGCCGTATCCAGCGCAGGGGCCCGTGCATCATC
TATAATGAGGATAATGGTATCATCAAGGCCTTCAGAAACATCCCTGGAATTACTCTGCTTAATGTAAGCAAGCTGAACATTTTGAAGCTT
GCTCCTGGTGGGCATGTGGGACGTTTCTGCATTTGGACTGAAAGTGCTTTCCGGAAGTTAGATGAATTGTACGGCACTTGGCGTAAAGCC
GCTTCCCTCAAGAGTAACTACAATCTTCCCATGCACAAGATGATTAATACAGATCTTAGCAGAATCTTGAAAAGCCCAGAGATCCAAAGA
GCCCTTCGAGCACCACGCAAGAAGATCCATCGCAGAGTCCTAAAGAAGAACCCACTGAAAAACTTGAGAATCATGTTGAAGCTAAACCCA
TATGCAAAGACCATGCGCCGGAACACCATTCTTCGCCAGGCCAGGAATCACAAGCTCCGGGTGGATAAGGCAGCTGCTGCAGCAGCGGCA
CTACAAGCCAAATCAGATGAGAAGGCGGCGGTTGCAGGCAAGAAGCCTGTGGTAGGTAAGAAAGGAAAGAAGGCTGCTGTTGGTGTTAAG
AAGCAGAAGAAGCCTCTGGTGGGAAAAAAGGCAGCAGCTACCAAGAAACCAGCCCCTGAAAAGAAGCCTGCAGAGAAGAAACCTACTACA
GAGGAGAAGAAGCCTGCTGCATAAACTCTTAAATTTGATTATTCCATAAAGGTCAAATCATTTTGGACAGCTTCTTTTGAATAAAGACCT
GATTATACAGGCAGTGAGAAACATGACTTGGTGTGCTCTGTAAAGCTTGGTTAGAATTTTTTTAAAGTGACATTTTGTTGGCCATAATTT
AGACTGTTACATTTTATATAGTGTGGTATAAAATGGGGCATGGATTTATACTAAGTCCATGGAGTTCAGTGGAAGGGGAATGATTTAAAA
AAAGTTGTGGTTTTCTAAATAATGTGGCTTGAAAAATAGGTGTAACAGGACTTGGTCAGAAACGCAGAGGCTGTTCAAGTTTAGCTCCCC
ACCAGATGGAAAATAGGTTAAATTCTGTAAAGATTTAACTTTAACCACAAGAGGGCACAACTGGAGAGCACAATTTTTTTGGTACTGCAG
TAAAATTGATTACCTCTTGAGAAGTGTTCTTTTTAACCAGCTATAACAATAGAGTTGAGTATTTTCACCCATGGTTTGAAAAAGTGCCAG
AAGGCCACACTGGCCCACATCTGTAATCCCAACACTTTGGGACCCTAAGGTGGGCAGAGCACTTGAGCCAATGAGTTCAAGACCAGCCTG
GTCAACATGATGAAATCTCGTCTCTACTGAAAATATAAAAAATAGCCAGTCATGGTGCATGCCTGTAACCCCAGCTACTTGGAGGCTGAG
GCAAGAGAATCACTTGAACCTGGGAGGTGGAGGTTGCAATGAGCCAAGATTGTACCATTGCCCTCCAGCCTGGGCGTCAGAGCAAGACTC
TCTGAAAAGTACCAGAAGCATTTTTCAGGACTGCCTGTGTGTCTTGGTGATTATGTTAACCAACTGTGTTCAAAAGAAGTACCCATGAAA
TGCCTCCAGATATAAGGGTGTTTTTTTTTACCCATAAAGCTAAACTGCAAATATTACCCTAGAATTAACCTCTTGTCCTGTGTCAAAAGT
CTTGTTTTGCATCTGGATTGTTAAACTGTCAGCTTCTCTCTGACAGTCTCGAACTGTCAAGACAGTCTCAGTTCACAGCCAAGGTGATCT
GTTAACCCTCCCCATTTCCAGGGCCAAATCTCAGTTCTTAAGCACGTCGTTTCTTAGCACGGCTTTATTTTCATGCTCTTTATTTCTCTA
TTTTGTGCAGCCTTACCCCTTTAAAGTCCACTGTGAGTCCTACCCTGCAGGGCCTCTTAACACAGTAGAGTTCATGTGCTACTGATTTGG
TGCCTGCCTTCAAACACATGTGCAAGTTTTGTGGGGTTAAAGATAGCCACTTGGTGGCACACCACATTGGAAGTGCTGTTCACCCGGTCA

>52857_52857_2_MEGF11-RPL4_MEGF11_chr15_66273116_ENST00000422354_RPL4_chr15_66795867_ENST00000307961_length(amino acids)=718AA_BP=292
MLAAPCSCLALWPGSGSGGQDRATGRPIPGPAAGAGPGMVLSLTGLIAFSFLQATLALNPEDPNVCSHWESYAVTVQESYAHPFDQIYYT
RCTDILNWFKCTRHRISYKTAYRRGLRTMYRRRSQCCPGYYESGDFCIPLCTEECVHGRCVSPDTCHCEPGWGGPDCSSGCDSDHWGPHC
SNRCQCQNGALCNPITGACVCAAGFRGWRCEELCAPGTHGKGCQLPCQCRHGASCDPRAGECLCAPGYTGVYCEELCPPGSHGAHCELRC
PCQNGGTCHHITGECACPPGWTACARPLISVYSEKGESSGKNVTLPAVFKAPIRPDIVNFVHTNLRKNNRQPYAVSELAGHQTSAESWGT
GRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMFAPTKTWRRWHRRVNTTQKRYAICSALAASALPALVMSKGHRIEEVPELPLVVEDKVE
GYKKTKEAVLLLKKLKAWNDIKKVYASQRMRAGKGKMRNRRRIQRRGPCIIYNEDNGIIKAFRNIPGITLLNVSKLNILKLAPGGHVGRF
CIWTESAFRKLDELYGTWRKAASLKSNYNLPMHKMINTDLSRILKSPEIQRALRAPRKKIHRRVLKKNPLKNLRIMLKLNPYAKTMRRNT

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MEGF11-RPL4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for MEGF11-RPL4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for MEGF11-RPL4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource