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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MEGF8-ITPKC (FusionGDB2 ID:52869)

Fusion Gene Summary for MEGF8-ITPKC

check button Fusion gene summary
Fusion gene informationFusion gene name: MEGF8-ITPKC
Fusion gene ID: 52869
HgeneTgene
Gene symbol

MEGF8

ITPKC

Gene ID

1954

80271

Gene namemultiple EGF like domains 8inositol-trisphosphate 3-kinase C
SynonymsC19orf49|CRPT2|EGFL4|SBP1IP3-3KC|IP3KC
Cytomap

19q13.2

19q13.2

Type of geneprotein-codingprotein-coding
Descriptionmultiple epidermal growth factor-like domains protein 8EGF-like domain-containing protein 4EGF-like-domain, multiple 4HBV pre-S2-binding protein 1HBV pre-s2 binding protein 1epidermal growth factor-like protein 4hepatitis B virus pre-S2-binding protinositol-trisphosphate 3-kinase CIP3 3-kinase CIP3K CInsP 3 kinase Cinositol 1,4,5-trisphosphate 3-kinase CinsP 3-kinase C
Modification date2020031320200313
UniProtAcc

Q7Z7M0

Q96DU7

Ensembl transtripts involved in fusion geneENST00000251268, ENST00000334370, 
ENST00000378073, 		ENST00000263370, 
Fusion gene scores* DoF score7 X 8 X 6=3366 X 5 X 4=120
# samples 86
** MAII scorelog2(8/336*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MEGF8 [Title/Abstract] AND ITPKC [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMEGF8(42875634)-ITPKC(41231245), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MEGF8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ITPKC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-IE-A3OV-01AMEGF8chr19

42875634

-ITPKCchr19

41231245

+
ChimerDB4SARCTCGA-IE-A3OV-01AMEGF8chr19

42875634

+ITPKCchr19

41231245

+


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Fusion Gene ORF analysis for MEGF8-ITPKC

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000251268ENST00000263370MEGF8chr19

42875634

+ITPKCchr19

41231245

+
In-frameENST00000334370ENST00000263370MEGF8chr19

42875634

+ITPKCchr19

41231245

+
intron-3CDSENST00000378073ENST00000263370MEGF8chr19

42875634

+ITPKCchr19

41231245

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000334370MEGF8chr1942875634+ENST00000263370ITPKCchr1941231245+9900770363585992654
ENST00000251268MEGF8chr1942875634+ENST00000263370ITPKCchr1941231245+94667269081652721

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000334370ENST00000263370MEGF8chr1942875634+ITPKCchr1941231245+0.0162188040.9837812
ENST00000251268ENST00000263370MEGF8chr1942875634+ITPKCchr1941231245+0.0085596940.9914403

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Fusion Genomic Features for MEGF8-ITPKC


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MEGF8-ITPKC


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:42875634/chr19:41231245)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MEGF8

Q7Z7M0

ITPKC

Q96DU7

FUNCTION: Acts as a negative regulator of hedgehog signaling. {ECO:0000250|UniProtKB:P60882}.FUNCTION: Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41421074_111524232846.0DomainEGF-like 3%3B calcium-binding
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41421163_121024232846.0DomainLaminin EGF-like 1
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41421211_126124232846.0DomainLaminin EGF-like 2
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41421263_140524232846.0DomainCUB 2
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+4142138_16824232846.0DomainEGF-like 1
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41421403_144524232846.0DomainEGF-like 4
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+4142170_20324232846.0DomainEGF-like 2
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41421876_191624232846.0DomainNote=PSI 4
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41421924_197924232846.0DomainNote=PSI 5
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41422060_211824232846.0DomainNote=PSI 6
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41422120_217724232846.0DomainNote=PSI 7
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41422178_221624232846.0DomainEGF-like 5
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41422253_230124232846.0DomainLaminin EGF-like 3
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+414230_14024232846.0DomainCUB 1
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+4142561_61324232846.0DomainNote=PSI 1
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+4142847_89924232846.0DomainNote=PSI 2
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+4142900_94724232846.0DomainNote=PSI 3
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40411074_111523562779.0DomainEGF-like 3%3B calcium-binding
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40411163_121023562779.0DomainLaminin EGF-like 1
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40411211_126123562779.0DomainLaminin EGF-like 2
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40411263_140523562779.0DomainCUB 2
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+4041138_16823562779.0DomainEGF-like 1
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40411403_144523562779.0DomainEGF-like 4
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+4041170_20323562779.0DomainEGF-like 2
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40411876_191623562779.0DomainNote=PSI 4
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40411924_197923562779.0DomainNote=PSI 5
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40412060_211823562779.0DomainNote=PSI 6
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40412120_217723562779.0DomainNote=PSI 7
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40412178_221623562779.0DomainEGF-like 5
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40412253_230123562779.0DomainLaminin EGF-like 3
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+404130_14023562779.0DomainCUB 1
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+4041561_61323562779.0DomainNote=PSI 1
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+4041847_89923562779.0DomainNote=PSI 2
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+4041900_94723562779.0DomainNote=PSI 3
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41421522_157024232846.0RepeatNote=Kelch 7
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41421580_162624232846.0RepeatNote=Kelch 8
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41421632_167924232846.0RepeatNote=Kelch 9
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41421685_173524232846.0RepeatNote=Kelch 10
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41421796_184324232846.0RepeatNote=Kelch 11
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41421852_189824232846.0RepeatNote=Kelch 12
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+4142241_28724232846.0RepeatNote=Kelch 1
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+4142290_33824232846.0RepeatNote=Kelch 2
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+4142346_39924232846.0RepeatNote=Kelch 3
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+4142402_45324232846.0RepeatNote=Kelch 4
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+4142459_51124232846.0RepeatNote=Kelch 5
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+4142525_57524232846.0RepeatNote=Kelch 6
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40411522_157023562779.0RepeatNote=Kelch 7
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40411580_162623562779.0RepeatNote=Kelch 8
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40411632_167923562779.0RepeatNote=Kelch 9
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40411685_173523562779.0RepeatNote=Kelch 10
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40411796_184323562779.0RepeatNote=Kelch 11
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40411852_189823562779.0RepeatNote=Kelch 12
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+4041241_28723562779.0RepeatNote=Kelch 1
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+4041290_33823562779.0RepeatNote=Kelch 2
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+4041346_39923562779.0RepeatNote=Kelch 3
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+4041402_45323562779.0RepeatNote=Kelch 4
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+4041459_51123562779.0RepeatNote=Kelch 5
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+4041525_57523562779.0RepeatNote=Kelch 6
TgeneITPKCchr19:42875634chr19:41231245ENST0000026337007471_473385684.0Nucleotide bindingATP
TgeneITPKCchr19:42875634chr19:41231245ENST0000026337007507_513385684.0RegionNote=Substrate binding
TgeneITPKCchr19:42875634chr19:41231245ENST0000026337007509_517385684.0RegionCalmodulin-binding
TgeneITPKCchr19:42875634chr19:41231245ENST0000026337007534_541385684.0RegionNote=Substrate binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41422528_256424232846.0Compositional biasNote=Pro-rich
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41422739_283324232846.0Compositional biasNote=Gly-rich
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40412528_256423562779.0Compositional biasNote=Pro-rich
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40412739_283323562779.0Compositional biasNote=Gly-rich
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41422380_244324232846.0DomainLaminin EGF-like 4
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40412380_244323562779.0DomainLaminin EGF-like 4
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41422669_284524232846.0Topological domainCytoplasmic
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+414228_264724232846.0Topological domainExtracellular
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40412669_284523562779.0Topological domainCytoplasmic
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+404128_264723562779.0Topological domainExtracellular
HgeneMEGF8chr19:42875634chr19:41231245ENST00000251268+41422648_266824232846.0TransmembraneHelical
HgeneMEGF8chr19:42875634chr19:41231245ENST00000334370+40412648_266823562779.0TransmembraneHelical
TgeneITPKCchr19:42875634chr19:41231245ENST0000026337007324_332385684.0MotifNuclear export signal


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Fusion Gene Sequence for MEGF8-ITPKC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>52869_52869_1_MEGF8-ITPKC_MEGF8_chr19_42875634_ENST00000251268_ITPKC_chr19_41231245_ENST00000263370_length(transcript)=9466nt_BP=7269nt
ATGGCCCTGGGCAAGGTTCTGGCCATGGCACTGGTTTTGGCCTTGGCCGTGCTGGGGTCGCTGTCCCCTGGGGCCCGGGCGGGGGACTGC
AAGGGGCAGCGGCAGGTGCTGCGGGAGGCGCCAGGCTTCGTGACGGATGGTGCGGGCAACTACAGCGTCAATGGCAACTGCGAGTGGCTC
ATCGAGGCCCCAAGCCCCCAGCACCGGATCCTGCTGGACTTCCTTTTCCTGGACACAGAGTGCACGTATGACTACCTGTTCGTGTATGAC
GGTGACTCCCCGCGAGGGCCGCTGCTTGCCAGTCTAAGTGGGAGCACCCGACCTCCGCCCATCGAAGCTTCCTCAGGCAAGATGCTGCTG
CACCTCTTCAGTGATGCCAACTACAACCTGCTGGGCTTTAACGCCTCATTCCGCTTCTCCCTGTGCCCGGGTGGCTGCCAGAGCCACGGG
CAGTGCCAGCCACCGGGTGTGTGTGCCTGCGAGCCGGGCTGGGGGGGTCCTGACTGTGGCCTGCAGGAGTGCTCAGCCTACTGTGGCAGC
CACGGCACCTGCGCCTCGCCCCTGGGACCATGCCGCTGTGAGCCTGGCTTCTTGGGACGTGCCTGTGACCTGCACCTGTGGGAGAACCAG
GGGGCTGGGTGGTGGCACAACGTGAGTGCCAGGGACCCTGCCTTCTCTGCCCGTATTGGGGCAGCTGGCGCCTTCCTGTCCCCACCAGGG
CTGCTGGCAGTTTTCGGAGGCCAGGACCTCAACAATGCCCTGGGTGACCTCGTCCTATACAACTTCTCCGCCAACACCTGGGAGTCTTGG
GACCTGAGTCCTGCCCCGGCTGCCCGTCACTCCCATGTGGCCGTGGCCTGGGCCGGCTCCCTGGTACTGATGGGTGGTGAGCTGGCTGAC
GGCTCGCTCACCAACGACGTGTGGGCCTTCAGTCCACTGGGCAGGGGCCACTGGGAGCTCCTGGCACCACCTGCCTCCAGCTCCTCGGGG
CCCCCAGGCCTGGCAGGTCACGCGGCTGCCCTGGTGGATGATGTCTGGCTATATGTGTCTGGAGGCCGCACCCCGCACGACCTCTTCTCC
TCTGGCCTCTTCCGTTTCCGCCTTGACAGCACCAGCGGGGGCTATTGGGAGCAGGTGATTCCGGCAGGCGGACGGCCCCCTGCTGCCACT
GGCCACTCCATGGTGTTCCATGCCCCCTCCCGTGCCCTGCTGGTCCATGGTGGACACCGGCCCTCCACTGCCCGGTTCTCTGTGCGAGTG
AACTCCACTGAGCTTTTCCACGTGGATCGGCATGTGTGGACGACGCTGAAGGGGCGGGATGGGCTTCAGGGCCCAAGGGAGCGAGCCTTC
CACACAGCCAGTGTTCTGGGCAATTACATGGTGGTCTATGGGGGCAATGTGCACACCCATTACCAGGAGGAAAAGTGCTACGAAGATGGC
ATCTTCTTCTACCACCTTGGCTGCCATCAATGGGTGTCAGGAGCTGAGCTTGCCCCGCCAGGAACCCCTGAGGGCCGAGCAGCGCCTCCC
AGTGGTCGGTACTCACATGTAGCTGCGGTGCTTGGTGGCAGCGTCCTGTTGGTGGCTGGGGGGTACAGCGGCCGGCCCCGTGGGGACTTG
ATGGCGTACAAGGTGCCCCCCTTTGTGTTCCAGGCACCTGCCCCTGACTACCACTTGGACTACTGCTCCATGTACACAGACCACAGCGTC
TGCTCCCGGGACCCGGAATGCAGTTGGTGCCAAGGAGCCTGCCAAGCTGCACCCCCTCCTGGGACCCCCTTGGGGGCTTGTCCAGCCGCC
AGCTGCCTGGGCCTGGGCCGCCTCCTGGGTGACTGCCAGGCCTGCCTGGCCTTCAGCAGCCCCACAGCCCCTCCACGGGGACCTGGCACC
CTGGGCTGGTGCGTGCACAATGAGAGCTGCCTCCCTAGGCCTGAGCAGGCCCGCTGCCGAGGGGAGCAGATCTCAGGCACTGTGGGCTGG
TGGGGGCCTGCGCCTGTCTTCGTCACGTCCCTGGAGGCCTGCGTCACCCAGAGCTTCCTGCCTGGCCTGCACTTGCTCACCTTTCAGCAG
CCGCCCAATACCTCCCAGCCTGACAAGGTCTCAATTGTCCGCAGCACGACCATCACCCTAACACCCAGCGCAGAGACAGATGTGTCCCTG
GTCTACCGTGGCTTCATCTACCCAATGCTGCCTGGAGGGCCAGGTGGACCAGGGGCTGAGGACGTGGCCGTGTGGACGCGGGCCCAGCGC
CTACACGTCCTGGCCCGGATGGCCCGTGGCCCTGACACGGAGAACATGGAGGAGGTGGGGCGCTGGGTGGCTCATCAGGAGAAGGAGACG
CGGCGGCTGCAGCGCCCTGGGTCTGCTCGCCTCTTCCCTCTGCCTGGGCGGGACCACAAGTATGCAGTAGAGATCCAGGGCCAGCTCAAT
GGCTCGGCAGGCCCTGGGCACAGCGAGCTAACTCTGCTGTGGGATCGGACTGGTGTGCCAGGAGGCAGCGAGATCTCCTTCTTCTTCCTG
GAGCCCTACCGCTCGTCGTCCTGCACCTCCTATTCTTCCTGCCTGGGCTGCTTGGCAGACCAGGGCTGTGGCTGGTGCCTGACCAGTGCC
ACCTGCCACCTGCGCCAGGGCGGAGCCCATTGCGGGGATGACGGGGCTGGTGGGTCCCTGCTGGTGCTGGTGCCTACCCTCTGCCCACTC
TGCGAGGAGCATCGGGACTGCCACGCCTGCACCCAGGACCCCTTCTGTGAGTGGCATCAGAGCACCAGCCGCAAAGGGGACGCGGCATGC
AGCCGGCGGGGCCGGGGTCGGGGTGCCCTGAAGAGTCCAGAGGAGTGTCCCCCGCTCTGCAGCCAGCGACTGACCTGTGAGGACTGCCTG
GCCAACTCTAGCCAGTGCGCCTGGTGCCAGTCCACCCACACCTGCTTCCTGTTTGCTGCCTACTTGGCCCGGTACCCACACGGGGGCTGT
CGAGGCTGGGACGACAGTGTACACTCGGAGCCACGGTGCCGGAGCTGCGATGGCTTCCTGACCTGCCATGAGTGTCTGCAGAGCCACGAG
TGTGGCTGGTGTGGCAATGAGGACAACCCCACACTGGGACGGTGCCTACAGGGGGACTTCTCAGGGCCCCTCGGTGGGGGTAACTGCTCC
CTGTGGGTGGGGGAGGGCCTGGGGCTTCCCGTGGCCCTCCCTGCCCGCTGGGCATACGCCCGCTGTCCTGACGTGGATGAGTGTCGCCTG
GGCCTGGCCCGGTGCCACCCGCGGGCGACCTGCCTGAACACGCCCCTCAGCTACGAGTGTCACTGCCAGCGGGGCTACCAGGGTGATGGC
ATCTCACACTGCAACCGCACGTGCTTGGAGGACTGTGGCCATGGTGTGTGCAGTGGCCCCCCGGACTTTACCTGCGTGTGTGACCTAGGC
TGGACATCAGACCTGCCCCCTCCCACACCCGCCCCGGGTCCGCCAGCCCCCCGCTGCTCCCGGGACTGTGGCTGCAGCTTCCACAGCCAC
TGCCGCAAGCGGGGCCCTGGCTTCTGCGACGAGTGCCAGGACTGGACATGGGGGGAGCACTGCGAACGATGCCGGCCCGGCAGCTTCGGC
AACGCCACAGGCTCTAGGGGCTGCCGGCCCTGCCAGTGCAACGGGCACGGGGACCCACGCCGTGGCCACTGCGACAACCTCAGTGGGCTC
TGCTTCTGCCAGGACCACACCGAGGGTGCCCACTGCCAGCTCTGCTCCCCAGGCTATTATGGGGATCCCCGGGCCGGTGGTTCCTGCTTT
CGGGAGTGTGGGGGTCGCGCCCTCCTCACCAACGTGTCCTCAGTGGCACTGGGCTCACGCCGGGTCGGGGGGCTGCTGCCTCCAGGTGGC
GGGGCTGCAAGAGCCGGGCCTGGCCTGTCCTACTGTGTGTGGGTTGTCTCGGCCACTGAGGAGCTACAGCCCTGTGCTCCCGGGACCCTC
TGTCCCCCACTCACCCTCACCTTCTCCCCCGACAGCAGCACCCCCTGCACGCTGAGCTACGTCCTGGCGTTTGATGGATTCCCACGCTTC
CTGGACACTGGTGTTGTCCAGTCGGACCGCAGCCTCATAGCTGCCTTCTGCGGCCAGCGACGGGACAGGCCCCTCACTGTTCAGGCCCTG
TCTGGGCTGCTCGTGCTGCACTGGGAGGCCAATGGCTCCTCATCCTGGGGCTTCAATGCTTCGGTGGGCTCTGCCCGCTGTGGGTCAGGG
GGCCCCGGGAGCTGTCCCGTCCCCCAGGAATGCGTGCCCCAGGACGGTGCTGCAGGTGCGGGGCTCTGCCGATGTCCTCAGGGCTGGGCT
GGCCCACACTGCCGCATGGCTCTGTGTCCTGAGAACTGCAATGCCCACACTGGGGCAGGAACTTGTAACCAGAGCCTGGGTGTGTGCATC
TGTGCCGAGGGCTTCGGGGGCCCCGACTGCGCCACCAAGCTGGATGGCGGGCAGCTGGTCTGGGAGACCCTCATGGACAGCCGCCTCTCA
GCCGACACTGCCAGCCGCTTCCTGCACCGCCTGGGCCACACCATGGTGGATGGACCCGATGCCACCTTGTGGATGTTTGGGGGCCTGGGC
CTGCCCCAGGGGCTGCTGGGAAACCTGTACAGGTACTCAGTGAGTGAGCGGCGGTGGACACAGATGCTGGCGGGAGCCGAGGACGGGGGC
CCAGGCCCATCGCCCCGCTCCTTCCATGCAGCCGCATATGTGCCCGCTGGCCGTGGTGCCATGTATCTGCTGGGGGGACTTACCGCTGGA
GGCGTCACCCGTGATTTCTGGGTCCTCAACCTCACCACCCTGCAATGGCGGCAGGAGAAGGCCCCCCAGACCGTGGAGCTGCCAGCCGTT
GCTGGTCACACCCTTACTGCCCGCCGAGGCCTGTCTCTGCTCCTGGTGGGCGGTTACTCCCCGGAAAATGGCTTCAACCAGCAGCTGCTG
GAGTACCAGCTGGCAACCGGCACCTGGGTGTCAGGAGCCCAGAGTGGGACACCCCCCACAGGTCTCTATGGTCACTCTGCTGTCTACCAC
GAGGCCACCGACTCCCTCTACGTGTTTGGGGGGTTCCGATTCCATGTGGAGCTGGCGGCCCCATCCCCCGAGCTCTACTCCCTGCACTGT
CCTGACCGCACCTGGAGTCTGCTGGCCCCTTCTCAGGGGGCAAAGCGAGATCGTATGAGGAATGTGCGTGGCTCATCTCGGGGTCTGGGC
CAAGTTCCTGGGGAGCAGCCTGGGTCATGGGGGTTCCGGGAAGTCAGGAAGAAGATGGCTCTGTGGGCTGCTCTTGCTGGTACAGGAGGT
TTCCTGGAGGAAATCTCACCTCACCTGAAGGAGCCCCGCCCCCGGCTTTTCCACGCCTCAGCCCTGTTAGGGGACACCATGGTGGTTCTT
GGGGGGCGCTCGGACCCTGACGAGTTCAGCAGCGACGTTCTGCTCTACCAGGTCAACTGCAATGCCTGGCTTCTGCCCGACCTCACCCGC
TCGGCCTCTGTGGGGCCCCCAATGGAGGAGTCTGTGGCCCATGCTGTGGCAGCAGTCGGGAGCCGCCTGTATATCTCTGGGGGTTTCGGG
GGAGTGGCCCTGGGCCGCCTGCTGGCACTGACCCTGCCCCCTGACCCCTGCCGCCTGCTGTCCTCACCTGAAGCTTGTAACCAGTCTGGG
GCCTGCACCTGGTGCCATGGGGCCTGCTTGTCCGGGGATCAGGCCCACAGGCTGGGCTGCGGGGGCTCCCCCTGCTCCCCAATGCCTCGC
TCCCCGGAGGAATGTCGACGTCTCCGGACCTGCAGTGAGTGCCTGGCCCGCCATCCTCGGACCCTGCAACCTGGAGATGGAGAGGCGTCC
ACCCCCCGCTGTAAGTGGTGTACCAACTGCCCCGAAGGTGCTTGCATTGGACGCAATGGGTCCTGCACCTCTGAGAATGACTGTCGGATC
AACCAGCGAGAGGTCTTCTGGGCAGGGAACTGCTCCGAGGCTGCGTGCGGGGCTGCTGACTGCGAGCAGTGCACGCGGGAGGGCAAGTGC
ATGTGGACGCGGCAGTTCAAGAGGACAGGGGAGACCCGCCGCATCCTCTCCGTGCAGCCCACCTATGACTGGACGTGCTTCAGCCACTCT
CTGCTGAATGTGTCCCCCATGCCGGTGGAATCATCACCCCCACTGCCCTGCCCCACCCCTTGTCACCTCCTACCCAACTGTACCTCCTGC
CTGGACTCTAAGGGAGCAGATGGGGGCTGGCAGCACTGTGTTTGGAGCAGCAGCCTGCAGCAGTGTCTGAGCCCTTCCTACCTGCCCCTG
CGATGTATGGCCGGAGGCTGTGGGCGGCTGCTCCGGGGACCTGAGAGCTGCTCCCTGGGCTGTGCTCAGGCAACTCAGTGCGCCTTGTGC
CTGCGGCGCCCCCATTGCGGCTGGTGTGCCTGGGGGGGCCAGGATGGGGGTGGCCGCTGCATGGAGGGTGGACTCAGCGGCCCCCGTGAT
GGGCTGACATGTGGGCGTCCGGGGGCCTCCTGGGCCTTCCTGTCCTGCCCCCCTGAGGACGAGTGTGCAAACGGGCACCACGACTGCAAC
GAGACGCAGAATTGCCACGACCAGCCCCACGGCTATGAGTGCAGCTGCAAGACCGGCTATACCATGGACAACATGACAGGGCTGTGCCGC
CCTGTGTGCGCCCAGGGCTGCGTGAACGGCTCATGTGTGGAGCCCGACCACTGCCGCTGCCACTTTGGCTTTGTGGGCCGCAACTGCTCC
ACGGAATGCCGCTGCAACCGCCACAGTGAATGCGCTGGTGTTGGGGCGCGTGACCACTGCTTGCTCTGCCGCAACCACACCAAGGGCAGC
CACTGTGAGCAGTGCCTCCCGCTGTTTGTGGGTTCAGCTGTCGGAGGCGGGACCTGCCGGCCCTGCCACGCCTTTTGTCGTGGAAATAGC
CACATCTGCATCTCCAGGAAGGAGTTACAAATGTCCAAGGGAGAGCCAAAGAAGTACTCACTGGACCCAGAGGAGATTGAAAACTGGGTG
ACAGAGGGTCCTAGTGAAGACGAGGCCGTGTGCGTGAACTGCCAGAATAACAGCTATGGGGAGAAATGCGAGAGCTGCCTGCAGGGCTAC
TTCCTCCTGGACGGGAAGTGCACCAAATGCCAGTGTAATGGCCACGCGGACACATGTAACGAGCAGGATGGGACGGGCTGTCCATGTCAG
AATAACACAGAGACGGGCACATGCCAGGGCAGCTCCCCCAGTGACCGTCGAGACTGCTACAAGTACCAGAGCAAACCCTGGAAGAAGCTG
AAGACAGTTCTGAAGTATTCACCCTTTGTGGTCTCCTTCCGAAAACACTACCCTTGGGTCCAGCTTTCTGGACATGCTGGGAACTTCCAG
GCAGGAGAGGATGGTCGGATTCTGAAACGTTTCTGTCAGTGTGAGCAGCGCAGCCTGGAGCAGCTGATGAAAGACCCGCTGCGACCTTTC
GTGCCTGCCTACTATGGCATGGTGCTGCAGGATGGCCAGACCTTCAACCAGATGGAAGACCTCCTGGCTGACTTTGAGGGCCCCTCCATT
ATGGACTGCAAGATGGGCAGCAGGACCTATCTGGAAGAGGAGCTAGTGAAGGCACGGGAACGTCCCCGTCCCCGGAAGGACATGTATGAG
AAGATGGTGGCTGTGGACCCTGGGGCCCCTACCCCTGAGGAGCATGCCCAGGGTGCAGTCACCAAGCCCCGCTACATGCAGTGGAGGGAA
ACCATGAGCTCCACCTCTACCCTGGGCTTCCGGATCGAGGGCATCAAGAAGGCAGATGGGACCTGTAACACCAACTTCAAGAAGACGCAG
GCACTGGAGCAGGTGACAAAAGTGCTGGAGGACTTCGTGGATGGAGACCACGTCATCCTGCAAAAGTACGTGGCATGCCTAGAAGAACTT
CGTGAAGCTCTGGAGATCTCCCCCTTCTTCAAGACCCACGAGGTGGTAGGCAGCTCCCTCCTCTTCGTGCACGACCACACCGGCCTGGCC
AAGGTCTGGATGATAGACTTCGGCAAGACGGTGGCCTTGCCCGACCACCAGACGCTCAGCCACAGGCTGCCCTGGGCTGAGGGCAACCGT
GAGGACGGCTACCTCTGGGGCCTGGACAACATGATCTGCCTCCTGCAGGGGCTGGCACAGAGCTGAGCTGCTCAGCCACCATCAGGTTAA
TTGGATGGCGCCAGTCTGGCTGGAGGAGCCCTGAGATGCCATGGGAGGCCTGAGGTTGGCCACGGGGGAGCTGGCCTCCAGGGACGGGAG
AGATTGTGTCATGTGCCACACGAGACCAACGTGGAAAAGTCTGAAGGGCCTTGGGAGACCAGGTAGCACCTGGCCCCATCATGATGCAGG
GGTTTTGGGGACCTGGAAGGAAGGTGATGAGGCAGTGAGTCAGAAAAACCAGAACGGGGTCCCCGGATCTGCCGGGAAGGCTTCTGAGGG
GCTGCCCTGAGAGCATTCAGTTCACATGTCACAGGGTATGGTGTGACAGGGTGCCTGTGGACACATGAATCACTTCTAACCTGCCTCCCT
GTCAGCCTCCAGGCTGCCAGCTGGCTGAGGCCAGGGACTGGGTCAGGCTCATCTGTGGCGCCTCAGAGGGTCAGCATCATTGGTGAACAG
ATGCAGGCGCTGCTGGACCATCTGGGGAGAGTGACAGTCCATGTCTTCACCAGGGAGCCATTTGAGTGCTGAGCGACAAGAGGCTCAGAG
GGCATGACCCCATGGGACTGGATGCGGCCTGAGGGCTGATACCGCTGGGCGGTATCCTGCCCTGCTGTGGCCCTGTGGGATCCTCCGTGT
TCCTCGGCGGACTCTGCTGACCTCCTGCAGACCCAAACCACAGCCACATCCCAGCTTCTGTGCCAGCACTGTGACAGTACCTCGCTCCTC
TGTGCACCAGATCCGGCCTCAGGACTTACACCTCCTGCCTGACCCCCAGGCTTCTCTCTCCTTTCTCCCAGCAAACTGCAGTGGCAGAAA
GGAGGTTCAGAGGCTGGGAAAGTGGGCCTCCCCTTGCAACTCAGAGCTGCTGCACTCAGGAGGGCCCCATCCAATCCCGGGCCCCTGCAG
GGAAAAGCGCTGGGTGTGTGTCAGAGGCGCAGGGTGGGTGGGGCTGCCAGCCAGGACCCTGGCCTGCAGCCTGATCCAAACCAAAGACTG
TAGAACCCTGGGGTGTGGCTAACGGCCCCTCCAGCACCCATAGCCAGGTCTTCCTGGCCCTTGAGGCTGGGCTGGCGGACAGGCACCTAC
CTCTTCCTTAAGCTGAAGCTCCCACACTGTCTTCCAGGGCTGAGGAGATGCTCTCCTTTTCTACTGACCATCTTGATACTTATTTATACG
AGAGGCAGTTGCTGGACGGGGTAGTACTGGGAAGCAGGAGGCAGAATGGCTCTGCTGAGCCTCCTACCCATGACAACACCCCAATAAACA

>52869_52869_1_MEGF8-ITPKC_MEGF8_chr19_42875634_ENST00000251268_ITPKC_chr19_41231245_ENST00000263370_length(amino acids)=2721AA_BP=2422
MALGKVLAMALVLALAVLGSLSPGARAGDCKGQRQVLREAPGFVTDGAGNYSVNGNCEWLIEAPSPQHRILLDFLFLDTECTYDYLFVYD
GDSPRGPLLASLSGSTRPPPIEASSGKMLLHLFSDANYNLLGFNASFRFSLCPGGCQSHGQCQPPGVCACEPGWGGPDCGLQECSAYCGS
HGTCASPLGPCRCEPGFLGRACDLHLWENQGAGWWHNVSARDPAFSARIGAAGAFLSPPGLLAVFGGQDLNNALGDLVLYNFSANTWESW
DLSPAPAARHSHVAVAWAGSLVLMGGELADGSLTNDVWAFSPLGRGHWELLAPPASSSSGPPGLAGHAAALVDDVWLYVSGGRTPHDLFS
SGLFRFRLDSTSGGYWEQVIPAGGRPPAATGHSMVFHAPSRALLVHGGHRPSTARFSVRVNSTELFHVDRHVWTTLKGRDGLQGPRERAF
HTASVLGNYMVVYGGNVHTHYQEEKCYEDGIFFYHLGCHQWVSGAELAPPGTPEGRAAPPSGRYSHVAAVLGGSVLLVAGGYSGRPRGDL
MAYKVPPFVFQAPAPDYHLDYCSMYTDHSVCSRDPECSWCQGACQAAPPPGTPLGACPAASCLGLGRLLGDCQACLAFSSPTAPPRGPGT
LGWCVHNESCLPRPEQARCRGEQISGTVGWWGPAPVFVTSLEACVTQSFLPGLHLLTFQQPPNTSQPDKVSIVRSTTITLTPSAETDVSL
VYRGFIYPMLPGGPGGPGAEDVAVWTRAQRLHVLARMARGPDTENMEEVGRWVAHQEKETRRLQRPGSARLFPLPGRDHKYAVEIQGQLN
GSAGPGHSELTLLWDRTGVPGGSEISFFFLEPYRSSSCTSYSSCLGCLADQGCGWCLTSATCHLRQGGAHCGDDGAGGSLLVLVPTLCPL
CEEHRDCHACTQDPFCEWHQSTSRKGDAACSRRGRGRGALKSPEECPPLCSQRLTCEDCLANSSQCAWCQSTHTCFLFAAYLARYPHGGC
RGWDDSVHSEPRCRSCDGFLTCHECLQSHECGWCGNEDNPTLGRCLQGDFSGPLGGGNCSLWVGEGLGLPVALPARWAYARCPDVDECRL
GLARCHPRATCLNTPLSYECHCQRGYQGDGISHCNRTCLEDCGHGVCSGPPDFTCVCDLGWTSDLPPPTPAPGPPAPRCSRDCGCSFHSH
CRKRGPGFCDECQDWTWGEHCERCRPGSFGNATGSRGCRPCQCNGHGDPRRGHCDNLSGLCFCQDHTEGAHCQLCSPGYYGDPRAGGSCF
RECGGRALLTNVSSVALGSRRVGGLLPPGGGAARAGPGLSYCVWVVSATEELQPCAPGTLCPPLTLTFSPDSSTPCTLSYVLAFDGFPRF
LDTGVVQSDRSLIAAFCGQRRDRPLTVQALSGLLVLHWEANGSSSWGFNASVGSARCGSGGPGSCPVPQECVPQDGAAGAGLCRCPQGWA
GPHCRMALCPENCNAHTGAGTCNQSLGVCICAEGFGGPDCATKLDGGQLVWETLMDSRLSADTASRFLHRLGHTMVDGPDATLWMFGGLG
LPQGLLGNLYRYSVSERRWTQMLAGAEDGGPGPSPRSFHAAAYVPAGRGAMYLLGGLTAGGVTRDFWVLNLTTLQWRQEKAPQTVELPAV
AGHTLTARRGLSLLLVGGYSPENGFNQQLLEYQLATGTWVSGAQSGTPPTGLYGHSAVYHEATDSLYVFGGFRFHVELAAPSPELYSLHC
PDRTWSLLAPSQGAKRDRMRNVRGSSRGLGQVPGEQPGSWGFREVRKKMALWAALAGTGGFLEEISPHLKEPRPRLFHASALLGDTMVVL
GGRSDPDEFSSDVLLYQVNCNAWLLPDLTRSASVGPPMEESVAHAVAAVGSRLYISGGFGGVALGRLLALTLPPDPCRLLSSPEACNQSG
ACTWCHGACLSGDQAHRLGCGGSPCSPMPRSPEECRRLRTCSECLARHPRTLQPGDGEASTPRCKWCTNCPEGACIGRNGSCTSENDCRI
NQREVFWAGNCSEAACGAADCEQCTREGKCMWTRQFKRTGETRRILSVQPTYDWTCFSHSLLNVSPMPVESSPPLPCPTPCHLLPNCTSC
LDSKGADGGWQHCVWSSSLQQCLSPSYLPLRCMAGGCGRLLRGPESCSLGCAQATQCALCLRRPHCGWCAWGGQDGGGRCMEGGLSGPRD
GLTCGRPGASWAFLSCPPEDECANGHHDCNETQNCHDQPHGYECSCKTGYTMDNMTGLCRPVCAQGCVNGSCVEPDHCRCHFGFVGRNCS
TECRCNRHSECAGVGARDHCLLCRNHTKGSHCEQCLPLFVGSAVGGGTCRPCHAFCRGNSHICISRKELQMSKGEPKKYSLDPEEIENWV
TEGPSEDEAVCVNCQNNSYGEKCESCLQGYFLLDGKCTKCQCNGHADTCNEQDGTGCPCQNNTETGTCQGSSPSDRRDCYKYQSKPWKKL
KTVLKYSPFVVSFRKHYPWVQLSGHAGNFQAGEDGRILKRFCQCEQRSLEQLMKDPLRPFVPAYYGMVLQDGQTFNQMEDLLADFEGPSI
MDCKMGSRTYLEEELVKARERPRPRKDMYEKMVAVDPGAPTPEEHAQGAVTKPRYMQWRETMSSTSTLGFRIEGIKKADGTCNTNFKKTQ
ALEQVTKVLEDFVDGDHVILQKYVACLEELREALEISPFFKTHEVVGSSLLFVHDHTGLAKVWMIDFGKTVALPDHQTLSHRLPWAEGNR

--------------------------------------------------------------
>52869_52869_2_MEGF8-ITPKC_MEGF8_chr19_42875634_ENST00000334370_ITPKC_chr19_41231245_ENST00000263370_length(transcript)=9900nt_BP=7703nt
GGCCGCTCTGGCCCAAGCGTCCCCTCGTCTCTCTGATCTGGCCCATCCGGCTTCGGAGGGAGGCGAGGGTGGGTGAGCAAAGGGATTGGG
TCTGTGGGGTCCAGGCCCGAACCCCTGAAGACGGGCTCCGCCCCCGGCACCCGCTCGCGCCCCGCCCCCGGCTGGAGGAGTCTCTCCTGG
ACCATCCGAACCTAGCCTGTCCCGGCCCGCAGCCTCTATGGAGGCTCCTGCCGGGCCGTAGAGCCCTTCGCCCCCTGGGGACCCACCCGT
CTATAAGGTCCGTTTGGCCTGCAGCAGCCTGAGTCCGTAATGCTGGGCACTGTTCATGGGATCGGCCCCCTATGGAGCCCTGTGTCTATA
GGGGACTCCTACGGTCCCTAGGGTTCGGCCCCGTCCATAATGACTCCATATACAGGGCCTTCCATCGCTCTATAGGGCTCAGCCCTCGGC
TTCCAGAGCCTGTCAGCAGTGGCCGTACCCTTCGCCGGGACTGCCGGGTCTCCGGGACCTCTTCGATCTACAAGGTCATGTTATGCCTAT
AGAGGTCGCATTTGCAGGGCCTCACCCCGGGTAGAGGGTCCTCTCCAGGTTTTTACGGCCTGTCCCCGCTCTAAGGGTCAGTGCAGGAGG
CGGCGATGGCCCTGGGCAAGGTTCTGGCCATGGCACTGGTTTTGGCCTTGGCCGTGCTGGGGTCGCTGTCCCCTGGGGCCCGGGCGGGGG
ACTGCAAGGGGCAGCGGCAGGTGCTGCGGGAGGCGCCAGGCTTCGTGACGGATGGTGCGGGCAACTACAGCGTCAATGGCAACTGCGAGT
GGCTCATCGAGGCCCCAAGCCCCCAGCACCGGATCCTGCTGGACTTCCTTTTCCTGGACACAGAGTGCACGTATGACTACCTGTTCGTGT
ATGACGGTGACTCCCCGCGAGGGCCGCTGCTTGCCAGTCTAAGTGGGAGCACCCGACCTCCGCCCATCGAAGCTTCCTCAGGCAAGATGC
TGCTGCACCTCTTCAGTGATGCCAACTACAACCTGCTGGGCTTTAACGCCTCATTCCGCTTCTCCCTGTGCCCGGGTGGCTGCCAGAGCC
ACGGGCAGTGCCAGCCACCGGGTGTGTGTGCCTGCGAGCCGGGCTGGGGGGGTCCTGACTGTGGCCTGCAGGAGTGCTCAGCCTACTGTG
GCAGCCACGGCACCTGCGCCTCGCCCCTGGGACCATGCCGCTGTGAGCCTGGCTTCTTGGGACGTGCCTGTGACCTGCACCTGTGGGAGA
ACCAGGGGGCTGGGTGGTGGCACAACGTGAGTGCCAGGGACCCTGCCTTCTCTGCCCGTATTGGGGCAGCTGGCGCCTTCCTGTCCCCAC
CAGGGCTGCTGGCAGTTTTCGGAGGCCAGGACCTCAACAATGCCCTGGGTGACCTCGTCCTATACAACTTCTCCGCCAACACCTGGGAGT
CTTGGGACCTGAGTCCTGCCCCGGCTGCCCGTCACTCCCATGTGGCCGTGGCCTGGGCCGGCTCCCTGGTACTGATGGGTGGTGAGCTGG
CTGACGGCTCGCTCACCAACGACGTGTGGGCCTTCAGTCCACTGGGCAGGGGCCACTGGGAGCTCCTGGCACCACCTGCCTCCAGCTCCT
CGGGGCCCCCAGGCCTGGCAGGTCACGCGGCTGCCCTGGTGGATGATGTCTGGCTATATGTGTCTGGAGGCCGCACCCCGCACGACCTCT
TCTCCTCTGGCCTCTTCCGTTTCCGCCTTGACAGCACCAGCGGGGGCTATTGGGAGCAGGTGATTCCGGCAGGCGGACGGCCCCCTGCTG
CCACTGGCCACTCCATGGTGTTCCATGCCCCCTCCCGTGCCCTGCTGGTCCATGGTGGACACCGGCCCTCCACTGCCCGGTTCTCTGTGC
GAGTGAACTCCACTGAGCTTTTCCACGTGGATCGGCATGTGTGGACGACGCTGAAGGGGCGGGATGGGCTTCAGGGCCCAAGGGAGCGAG
CCTTCCACACAGCCAGTGTTCTGGGCAATTACATGGTGGTCTATGGGGGCAATGTGCACACCCATTACCAGGAGGAAAAGTGCTACGAAG
ATGGCATCTTCTTCTACCACCTTGGCTGCCATCAATGGGTGTCAGGAGCTGAGCTTGCCCCGCCAGGAACCCCTGAGGGCCGAGCAGCGC
CTCCCAGTGGTCGGTACTCACATGTAGCTGCGGTGCTTGGTGGCAGCGTCCTGTTGGTGGCTGGGGGGTACAGCGGCCGGCCCCGTGGGG
ACTTGATGGCGTACAAGGTGCCCCCCTTTGTGTTCCAGGCACCTGCCCCTGACTACCACTTGGACTACTGCTCCATGTACACAGACCACA
GCGTCTGCTCCCGGGACCCGGAATGCAGTTGGTGCCAAGGAGCCTGCCAAGCTGCACCCCCTCCTGGGACCCCCTTGGGGGCTTGTCCAG
CCGCCAGCTGCCTGGGCCTGGGCCGCCTCCTGGGTGACTGCCAGGCCTGCCTGGCCTTCAGCAGCCCCACAGCCCCTCCACGGGGACCTG
GCACCCTGGGCTGGTGCGTGCACAATGAGAGCTGCCTCCCTAGGCCTGAGCAGGCCCGCTGCCGAGGGGAGCAGATCTCAGGCACTGTGG
GCTGGTGGGGGCCTGCGCCTGTCTTCGTCACGTCCCTGGAGGCCTGCGTCACCCAGAGCTTCCTGCCTGGCCTGCACTTGCTCACCTTTC
AGCAGCCGCCCAATACCTCCCAGCCTGACAAGGAGGAGGTGGGGCGCTGGGTGGCTCATCAGGAGAAGGAGACGCGGCGGCTGCAGCGCC
CTGGGTCTGCTCGCCTCTTCCCTCTGCCTGGGCGGGACCACAAGTATGCAGTAGAGATCCAGGGCCAGCTCAATGGCTCGGCAGGCCCTG
GGCACAGCGAGCTAACTCTGCTGTGGGATCGGACTGGTGTGCCAGGAGGCAGCGAGATCTCCTTCTTCTTCCTGGAGCCCTACCGCTCGT
CGTCCTGCACCTCCTATTCTTCCTGCCTGGGCTGCTTGGCAGACCAGGGCTGTGGCTGGTGCCTGACCAGTGCCACCTGCCACCTGCGCC
AGGGCGGAGCCCATTGCGGGGATGACGGGGCTGGTGGGTCCCTGCTGGTGCTGGTGCCTACCCTCTGCCCACTCTGCGAGGAGCATCGGG
ACTGCCACGCCTGCACCCAGGACCCCTTCTGTGAGTGGCATCAGAGCACCAGCCGCAAAGGGGACGCGGCATGCAGCCGGCGGGGCCGGG
GTCGGGGTGCCCTGAAGAGTCCAGAGGAGTGTCCCCCGCTCTGCAGCCAGCGACTGACCTGTGAGGACTGCCTGGCCAACTCTAGCCAGT
GCGCCTGGTGCCAGTCCACCCACACCTGCTTCCTGTTTGCTGCCTACTTGGCCCGGTACCCACACGGGGGCTGTCGAGGCTGGGACGACA
GTGTACACTCGGAGCCACGGTGCCGGAGCTGCGATGGCTTCCTGACCTGCCATGAGTGTCTGCAGAGCCACGAGTGTGGCTGGTGTGGCA
ATGAGGACAACCCCACACTGGGACGGTGCCTACAGGGGGACTTCTCAGGGCCCCTCGGTGGGGGTAACTGCTCCCTGTGGGTGGGGGAGG
GCCTGGGGCTTCCCGTGGCCCTCCCTGCCCGCTGGGCATACGCCCGCTGTCCTGACGTGGATGAGTGTCGCCTGGGCCTGGCCCGGTGCC
ACCCGCGGGCGACCTGCCTGAACACGCCCCTCAGCTACGAGTGTCACTGCCAGCGGGGCTACCAGGGTGATGGCATCTCACACTGCAACC
GCACGTGCTTGGAGGACTGTGGCCATGGTGTGTGCAGTGGCCCCCCGGACTTTACCTGCGTGTGTGACCTAGGCTGGACATCAGACCTGC
CCCCTCCCACACCCGCCCCGGGTCCGCCAGCCCCCCGCTGCTCCCGGGACTGTGGCTGCAGCTTCCACAGCCACTGCCGCAAGCGGGGCC
CTGGCTTCTGCGACGAGTGCCAGGACTGGACATGGGGGGAGCACTGCGAACGATGCCGGCCCGGCAGCTTCGGCAACGCCACAGGCTCTA
GGGGCTGCCGGCCCTGCCAGTGCAACGGGCACGGGGACCCACGCCGTGGCCACTGCGACAACCTCAGTGGGCTCTGCTTCTGCCAGGACC
ACACCGAGGGTGCCCACTGCCAGCTCTGCTCCCCAGGCTATTATGGGGATCCCCGGGCCGGTGGTTCCTGCTTTCGGGAGTGTGGGGGTC
GCGCCCTCCTCACCAACGTGTCCTCAGTGGCACTGGGCTCACGCCGGGTCGGGGGGCTGCTGCCTCCAGGTGGCGGGGCTGCAAGAGCCG
GGCCTGGCCTGTCCTACTGTGTGTGGGTTGTCTCGGCCACTGAGGAGCTACAGCCCTGTGCTCCCGGGACCCTCTGTCCCCCACTCACCC
TCACCTTCTCCCCCGACAGCAGCACCCCCTGCACGCTGAGCTACGTCCTGGCGTTTGATGGATTCCCACGCTTCCTGGACACTGGTGTTG
TCCAGTCGGACCGCAGCCTCATAGCTGCCTTCTGCGGCCAGCGACGGGACAGGCCCCTCACTGTTCAGGCCCTGTCTGGGCTGCTCGTGC
TGCACTGGGAGGCCAATGGCTCCTCATCCTGGGGCTTCAATGCTTCGGTGGGCTCTGCCCGCTGTGGGTCAGGGGGCCCCGGGAGCTGTC
CCGTCCCCCAGGAATGCGTGCCCCAGGACGGTGCTGCAGGTGCGGGGCTCTGCCGATGTCCTCAGGGCTGGGCTGGCCCACACTGCCGCA
TGGCTCTGTGTCCTGAGAACTGCAATGCCCACACTGGGGCAGGAACTTGTAACCAGAGCCTGGGTGTGTGCATCTGTGCCGAGGGCTTCG
GGGGCCCCGACTGCGCCACCAAGCTGGATGGCGGGCAGCTGGTCTGGGAGACCCTCATGGACAGCCGCCTCTCAGCCGACACTGCCAGCC
GCTTCCTGCACCGCCTGGGCCACACCATGGTGGATGGACCCGATGCCACCTTGTGGATGTTTGGGGGCCTGGGCCTGCCCCAGGGGCTGC
TGGGAAACCTGTACAGGTACTCAGTGAGTGAGCGGCGGTGGACACAGATGCTGGCGGGAGCCGAGGACGGGGGCCCAGGCCCATCGCCCC
GCTCCTTCCATGCAGCCGCATATGTGCCCGCTGGCCGTGGTGCCATGTATCTGCTGGGGGGACTTACCGCTGGAGGCGTCACCCGTGATT
TCTGGGTCCTCAACCTCACCACCCTGCAATGGCGGCAGGAGAAGGCCCCCCAGACCGTGGAGCTGCCAGCCGTTGCTGGTCACACCCTTA
CTGCCCGCCGAGGCCTGTCTCTGCTCCTGGTGGGCGGTTACTCCCCGGAAAATGGCTTCAACCAGCAGCTGCTGGAGTACCAGCTGGCAA
CCGGCACCTGGGTGTCAGGAGCCCAGAGTGGGACACCCCCCACAGGTCTCTATGGTCACTCTGCTGTCTACCACGAGGCCACCGACTCCC
TCTACGTGTTTGGGGGGTTCCGATTCCATGTGGAGCTGGCGGCCCCATCCCCCGAGCTCTACTCCCTGCACTGTCCTGACCGCACCTGGA
GTCTGCTGGCCCCTTCTCAGGGGGCAAAGCGAGATCGTATGAGGAATGTGCGTGGCTCATCTCGGGGTCTGGGCCAAGTTCCTGGGGAGC
AGCCTGGGTCATGGGGGTTCCGGGAAGTCAGGAAGAAGATGGCTCTGTGGGCTGCTCTTGCTGGTACAGGAGGTTTCCTGGAGGAAATCT
CACCTCACCTGAAGGAGCCCCGCCCCCGGCTTTTCCACGCCTCAGCCCTGTTAGGGGACACCATGGTGGTTCTTGGGGGGCGCTCGGACC
CTGACGAGTTCAGCAGCGACGTTCTGCTCTACCAGGTCAACTGCAATGCCTGGCTTCTGCCCGACCTCACCCGCTCGGCCTCTGTGGGGC
CCCCAATGGAGGAGTCTGTGGCCCATGCTGTGGCAGCAGTCGGGAGCCGCCTGTATATCTCTGGGGGTTTCGGGGGAGTGGCCCTGGGCC
GCCTGCTGGCACTGACCCTGCCCCCTGACCCCTGCCGCCTGCTGTCCTCACCTGAAGCTTGTAACCAGTCTGGGGCCTGCACCTGGTGCC
ATGGGGCCTGCTTGTCCGGGGATCAGGCCCACAGGCTGGGCTGCGGGGGCTCCCCCTGCTCCCCAATGCCTCGCTCCCCGGAGGAATGTC
GACGTCTCCGGACCTGCAGTGAGTGCCTGGCCCGCCATCCTCGGACCCTGCAACCTGGAGATGGAGAGGCGTCCACCCCCCGCTGTAAGT
GGTGTACCAACTGCCCCGAAGGTGCTTGCATTGGACGCAATGGGTCCTGCACCTCTGAGAATGACTGTCGGATCAACCAGCGAGAGGTCT
TCTGGGCAGGGAACTGCTCCGAGGCTGCGTGCGGGGCTGCTGACTGCGAGCAGTGCACGCGGGAGGGCAAGTGCATGTGGACGCGGCAGT
TCAAGAGGACAGGGGAGACCCGCCGCATCCTCTCCGTGCAGCCCACCTATGACTGGACGTGCTTCAGCCACTCTCTGCTGAATGTGTCCC
CCATGCCGGTGGAATCATCACCCCCACTGCCCTGCCCCACCCCTTGTCACCTCCTACCCAACTGTACCTCCTGCCTGGACTCTAAGGGAG
CAGATGGGGGCTGGCAGCACTGTGTTTGGAGCAGCAGCCTGCAGCAGTGTCTGAGCCCTTCCTACCTGCCCCTGCGATGTATGGCCGGAG
GCTGTGGGCGGCTGCTCCGGGGACCTGAGAGCTGCTCCCTGGGCTGTGCTCAGGCAACTCAGTGCGCCTTGTGCCTGCGGCGCCCCCATT
GCGGCTGGTGTGCCTGGGGGGGCCAGGATGGGGGTGGCCGCTGCATGGAGGGTGGACTCAGCGGCCCCCGTGATGGGCTGACATGTGGGC
GTCCGGGGGCCTCCTGGGCCTTCCTGTCCTGCCCCCCTGAGGACGAGTGTGCAAACGGGCACCACGACTGCAACGAGACGCAGAATTGCC
ACGACCAGCCCCACGGCTATGAGTGCAGCTGCAAGACCGGCTATACCATGGACAACATGACAGGGCTGTGCCGCCCTGTGTGCGCCCAGG
GCTGCGTGAACGGCTCATGTGTGGAGCCCGACCACTGCCGCTGCCACTTTGGCTTTGTGGGCCGCAACTGCTCCACGGAATGCCGCTGCA
ACCGCCACAGTGAATGCGCTGGTGTTGGGGCGCGTGACCACTGCTTGCTCTGCCGCAACCACACCAAGGGCAGCCACTGTGAGCAGTGCC
TCCCGCTGTTTGTGGGTTCAGCTGTCGGAGGCGGGACCTGCCGGCCCTGCCACGCCTTTTGTCGTGGAAATAGCCACATCTGCATCTCCA
GGAAGGAGTTACAAATGTCCAAGGGAGAGCCAAAGAAGTACTCACTGGACCCAGAGGAGATTGAAAACTGGGTGACAGAGGGTCCTAGTG
AAGACGAGGCCGTGTGCGTGAACTGCCAGAATAACAGCTATGGGGAGAAATGCGAGAGCTGCCTGCAGGGCTACTTCCTCCTGGACGGGA
AGTGCACCAAATGCCAGTGTAATGGCCACGCGGACACATGTAACGAGCAGGATGGGACGGGCTGTCCATGTCAGAATAACACAGAGACGG
GCACATGCCAGGGCAGCTCCCCCAGTGACCGTCGAGACTGCTACAAGTACCAGAGCAAACCCTGGAAGAAGCTGAAGACAGTTCTGAAGT
ATTCACCCTTTGTGGTCTCCTTCCGAAAACACTACCCTTGGGTCCAGCTTTCTGGACATGCTGGGAACTTCCAGGCAGGAGAGGATGGTC
GGATTCTGAAACGTTTCTGTCAGTGTGAGCAGCGCAGCCTGGAGCAGCTGATGAAAGACCCGCTGCGACCTTTCGTGCCTGCCTACTATG
GCATGGTGCTGCAGGATGGCCAGACCTTCAACCAGATGGAAGACCTCCTGGCTGACTTTGAGGGCCCCTCCATTATGGACTGCAAGATGG
GCAGCAGGACCTATCTGGAAGAGGAGCTAGTGAAGGCACGGGAACGTCCCCGTCCCCGGAAGGACATGTATGAGAAGATGGTGGCTGTGG
ACCCTGGGGCCCCTACCCCTGAGGAGCATGCCCAGGGTGCAGTCACCAAGCCCCGCTACATGCAGTGGAGGGAAACCATGAGCTCCACCT
CTACCCTGGGCTTCCGGATCGAGGGCATCAAGAAGGCAGATGGGACCTGTAACACCAACTTCAAGAAGACGCAGGCACTGGAGCAGGTGA
CAAAAGTGCTGGAGGACTTCGTGGATGGAGACCACGTCATCCTGCAAAAGTACGTGGCATGCCTAGAAGAACTTCGTGAAGCTCTGGAGA
TCTCCCCCTTCTTCAAGACCCACGAGGTGGTAGGCAGCTCCCTCCTCTTCGTGCACGACCACACCGGCCTGGCCAAGGTCTGGATGATAG
ACTTCGGCAAGACGGTGGCCTTGCCCGACCACCAGACGCTCAGCCACAGGCTGCCCTGGGCTGAGGGCAACCGTGAGGACGGCTACCTCT
GGGGCCTGGACAACATGATCTGCCTCCTGCAGGGGCTGGCACAGAGCTGAGCTGCTCAGCCACCATCAGGTTAATTGGATGGCGCCAGTC
TGGCTGGAGGAGCCCTGAGATGCCATGGGAGGCCTGAGGTTGGCCACGGGGGAGCTGGCCTCCAGGGACGGGAGAGATTGTGTCATGTGC
CACACGAGACCAACGTGGAAAAGTCTGAAGGGCCTTGGGAGACCAGGTAGCACCTGGCCCCATCATGATGCAGGGGTTTTGGGGACCTGG
AAGGAAGGTGATGAGGCAGTGAGTCAGAAAAACCAGAACGGGGTCCCCGGATCTGCCGGGAAGGCTTCTGAGGGGCTGCCCTGAGAGCAT
TCAGTTCACATGTCACAGGGTATGGTGTGACAGGGTGCCTGTGGACACATGAATCACTTCTAACCTGCCTCCCTGTCAGCCTCCAGGCTG
CCAGCTGGCTGAGGCCAGGGACTGGGTCAGGCTCATCTGTGGCGCCTCAGAGGGTCAGCATCATTGGTGAACAGATGCAGGCGCTGCTGG
ACCATCTGGGGAGAGTGACAGTCCATGTCTTCACCAGGGAGCCATTTGAGTGCTGAGCGACAAGAGGCTCAGAGGGCATGACCCCATGGG
ACTGGATGCGGCCTGAGGGCTGATACCGCTGGGCGGTATCCTGCCCTGCTGTGGCCCTGTGGGATCCTCCGTGTTCCTCGGCGGACTCTG
CTGACCTCCTGCAGACCCAAACCACAGCCACATCCCAGCTTCTGTGCCAGCACTGTGACAGTACCTCGCTCCTCTGTGCACCAGATCCGG
CCTCAGGACTTACACCTCCTGCCTGACCCCCAGGCTTCTCTCTCCTTTCTCCCAGCAAACTGCAGTGGCAGAAAGGAGGTTCAGAGGCTG
GGAAAGTGGGCCTCCCCTTGCAACTCAGAGCTGCTGCACTCAGGAGGGCCCCATCCAATCCCGGGCCCCTGCAGGGAAAAGCGCTGGGTG
TGTGTCAGAGGCGCAGGGTGGGTGGGGCTGCCAGCCAGGACCCTGGCCTGCAGCCTGATCCAAACCAAAGACTGTAGAACCCTGGGGTGT
GGCTAACGGCCCCTCCAGCACCCATAGCCAGGTCTTCCTGGCCCTTGAGGCTGGGCTGGCGGACAGGCACCTACCTCTTCCTTAAGCTGA
AGCTCCCACACTGTCTTCCAGGGCTGAGGAGATGCTCTCCTTTTCTACTGACCATCTTGATACTTATTTATACGAGAGGCAGTTGCTGGA
CGGGGTAGTACTGGGAAGCAGGAGGCAGAATGGCTCTGCTGAGCCTCCTACCCATGACAACACCCCAATAAACAGAACATTCAGAGCCAA

>52869_52869_2_MEGF8-ITPKC_MEGF8_chr19_42875634_ENST00000334370_ITPKC_chr19_41231245_ENST00000263370_length(amino acids)=2654AA_BP=2355
MALGKVLAMALVLALAVLGSLSPGARAGDCKGQRQVLREAPGFVTDGAGNYSVNGNCEWLIEAPSPQHRILLDFLFLDTECTYDYLFVYD
GDSPRGPLLASLSGSTRPPPIEASSGKMLLHLFSDANYNLLGFNASFRFSLCPGGCQSHGQCQPPGVCACEPGWGGPDCGLQECSAYCGS
HGTCASPLGPCRCEPGFLGRACDLHLWENQGAGWWHNVSARDPAFSARIGAAGAFLSPPGLLAVFGGQDLNNALGDLVLYNFSANTWESW
DLSPAPAARHSHVAVAWAGSLVLMGGELADGSLTNDVWAFSPLGRGHWELLAPPASSSSGPPGLAGHAAALVDDVWLYVSGGRTPHDLFS
SGLFRFRLDSTSGGYWEQVIPAGGRPPAATGHSMVFHAPSRALLVHGGHRPSTARFSVRVNSTELFHVDRHVWTTLKGRDGLQGPRERAF
HTASVLGNYMVVYGGNVHTHYQEEKCYEDGIFFYHLGCHQWVSGAELAPPGTPEGRAAPPSGRYSHVAAVLGGSVLLVAGGYSGRPRGDL
MAYKVPPFVFQAPAPDYHLDYCSMYTDHSVCSRDPECSWCQGACQAAPPPGTPLGACPAASCLGLGRLLGDCQACLAFSSPTAPPRGPGT
LGWCVHNESCLPRPEQARCRGEQISGTVGWWGPAPVFVTSLEACVTQSFLPGLHLLTFQQPPNTSQPDKEEVGRWVAHQEKETRRLQRPG
SARLFPLPGRDHKYAVEIQGQLNGSAGPGHSELTLLWDRTGVPGGSEISFFFLEPYRSSSCTSYSSCLGCLADQGCGWCLTSATCHLRQG
GAHCGDDGAGGSLLVLVPTLCPLCEEHRDCHACTQDPFCEWHQSTSRKGDAACSRRGRGRGALKSPEECPPLCSQRLTCEDCLANSSQCA
WCQSTHTCFLFAAYLARYPHGGCRGWDDSVHSEPRCRSCDGFLTCHECLQSHECGWCGNEDNPTLGRCLQGDFSGPLGGGNCSLWVGEGL
GLPVALPARWAYARCPDVDECRLGLARCHPRATCLNTPLSYECHCQRGYQGDGISHCNRTCLEDCGHGVCSGPPDFTCVCDLGWTSDLPP
PTPAPGPPAPRCSRDCGCSFHSHCRKRGPGFCDECQDWTWGEHCERCRPGSFGNATGSRGCRPCQCNGHGDPRRGHCDNLSGLCFCQDHT
EGAHCQLCSPGYYGDPRAGGSCFRECGGRALLTNVSSVALGSRRVGGLLPPGGGAARAGPGLSYCVWVVSATEELQPCAPGTLCPPLTLT
FSPDSSTPCTLSYVLAFDGFPRFLDTGVVQSDRSLIAAFCGQRRDRPLTVQALSGLLVLHWEANGSSSWGFNASVGSARCGSGGPGSCPV
PQECVPQDGAAGAGLCRCPQGWAGPHCRMALCPENCNAHTGAGTCNQSLGVCICAEGFGGPDCATKLDGGQLVWETLMDSRLSADTASRF
LHRLGHTMVDGPDATLWMFGGLGLPQGLLGNLYRYSVSERRWTQMLAGAEDGGPGPSPRSFHAAAYVPAGRGAMYLLGGLTAGGVTRDFW
VLNLTTLQWRQEKAPQTVELPAVAGHTLTARRGLSLLLVGGYSPENGFNQQLLEYQLATGTWVSGAQSGTPPTGLYGHSAVYHEATDSLY
VFGGFRFHVELAAPSPELYSLHCPDRTWSLLAPSQGAKRDRMRNVRGSSRGLGQVPGEQPGSWGFREVRKKMALWAALAGTGGFLEEISP
HLKEPRPRLFHASALLGDTMVVLGGRSDPDEFSSDVLLYQVNCNAWLLPDLTRSASVGPPMEESVAHAVAAVGSRLYISGGFGGVALGRL
LALTLPPDPCRLLSSPEACNQSGACTWCHGACLSGDQAHRLGCGGSPCSPMPRSPEECRRLRTCSECLARHPRTLQPGDGEASTPRCKWC
TNCPEGACIGRNGSCTSENDCRINQREVFWAGNCSEAACGAADCEQCTREGKCMWTRQFKRTGETRRILSVQPTYDWTCFSHSLLNVSPM
PVESSPPLPCPTPCHLLPNCTSCLDSKGADGGWQHCVWSSSLQQCLSPSYLPLRCMAGGCGRLLRGPESCSLGCAQATQCALCLRRPHCG
WCAWGGQDGGGRCMEGGLSGPRDGLTCGRPGASWAFLSCPPEDECANGHHDCNETQNCHDQPHGYECSCKTGYTMDNMTGLCRPVCAQGC
VNGSCVEPDHCRCHFGFVGRNCSTECRCNRHSECAGVGARDHCLLCRNHTKGSHCEQCLPLFVGSAVGGGTCRPCHAFCRGNSHICISRK
ELQMSKGEPKKYSLDPEEIENWVTEGPSEDEAVCVNCQNNSYGEKCESCLQGYFLLDGKCTKCQCNGHADTCNEQDGTGCPCQNNTETGT
CQGSSPSDRRDCYKYQSKPWKKLKTVLKYSPFVVSFRKHYPWVQLSGHAGNFQAGEDGRILKRFCQCEQRSLEQLMKDPLRPFVPAYYGM
VLQDGQTFNQMEDLLADFEGPSIMDCKMGSRTYLEEELVKARERPRPRKDMYEKMVAVDPGAPTPEEHAQGAVTKPRYMQWRETMSSTST
LGFRIEGIKKADGTCNTNFKKTQALEQVTKVLEDFVDGDHVILQKYVACLEELREALEISPFFKTHEVVGSSLLFVHDHTGLAKVWMIDF

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Fusion Gene PPI Analysis for MEGF8-ITPKC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MEGF8-ITPKC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MEGF8-ITPKC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource