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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MEIS2-BBS2 (FusionGDB2 ID:52891)

Fusion Gene Summary for MEIS2-BBS2

check button Fusion gene summary
Fusion gene informationFusion gene name: MEIS2-BBS2
Fusion gene ID: 52891
HgeneTgene
Gene symbol

MEIS2

BBS2

Gene ID

4212

583

Gene nameMeis homeobox 2Bardet-Biedl syndrome 2
SynonymsCPCMR|HsT18361|MRG1BBS|RP74
Cytomap

15q14

16q13

Type of geneprotein-codingprotein-coding
Descriptionhomeobox protein Meis2Meis homolog 2Meis1, myeloid ecotropic viral integration site 1 homolog 2Meis1-related gene 1TALE homeobox protein Meis2meis1-related protein 1Bardet-Biedl syndrome 2 protein
Modification date2020031320200313
UniProtAcc

O14770

Q9BXC9

Ensembl transtripts involved in fusion geneENST00000340545, ENST00000382766, 
ENST00000397620, ENST00000557796, 
ENST00000559561, ENST00000561208, 
ENST00000219869, ENST00000338564, 
ENST00000397624, ENST00000424352, 
ENST00000444725, ENST00000559085, 
ENST00000559408, 		ENST00000245157, 
ENST00000561951, ENST00000568104, 
Fusion gene scores* DoF score25 X 16 X 6=24005 X 5 X 5=125
# samples 277
** MAII scorelog2(27/2400*10)=-3.15200309344505
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/125*10)=-0.836501267717121
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MEIS2 [Title/Abstract] AND BBS2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMEIS2(37242525)-BBS2(56545196), # samples:2
Anticipated loss of major functional domain due to fusion event.MEIS2-BBS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
MEIS2-BBS2 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMEIS2

GO:0045931

positive regulation of mitotic cell cycle

26512644

HgeneMEIS2

GO:0045944

positive regulation of transcription by RNA polymerase II

10764806

HgeneMEIS2

GO:0110024

positive regulation of cardiac muscle myoblast proliferation

26512644


check buttonFusion gene breakpoints across MEIS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BBS2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-WP-A9GB-01AMEIS2chr15

37242525

-BBS2chr16

56545196

-


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Fusion Gene ORF analysis for MEIS2-BBS2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000340545ENST00000245157MEIS2chr15

37242525

-BBS2chr16

56545196

-
Frame-shiftENST00000340545ENST00000561951MEIS2chr15

37242525

-BBS2chr16

56545196

-
Frame-shiftENST00000340545ENST00000568104MEIS2chr15

37242525

-BBS2chr16

56545196

-
Frame-shiftENST00000382766ENST00000245157MEIS2chr15

37242525

-BBS2chr16

56545196

-
Frame-shiftENST00000382766ENST00000561951MEIS2chr15

37242525

-BBS2chr16

56545196

-
Frame-shiftENST00000382766ENST00000568104MEIS2chr15

37242525

-BBS2chr16

56545196

-
Frame-shiftENST00000397620ENST00000245157MEIS2chr15

37242525

-BBS2chr16

56545196

-
Frame-shiftENST00000397620ENST00000561951MEIS2chr15

37242525

-BBS2chr16

56545196

-
Frame-shiftENST00000397620ENST00000568104MEIS2chr15

37242525

-BBS2chr16

56545196

-
Frame-shiftENST00000557796ENST00000245157MEIS2chr15

37242525

-BBS2chr16

56545196

-
Frame-shiftENST00000557796ENST00000561951MEIS2chr15

37242525

-BBS2chr16

56545196

-
Frame-shiftENST00000557796ENST00000568104MEIS2chr15

37242525

-BBS2chr16

56545196

-
Frame-shiftENST00000559561ENST00000245157MEIS2chr15

37242525

-BBS2chr16

56545196

-
Frame-shiftENST00000559561ENST00000561951MEIS2chr15

37242525

-BBS2chr16

56545196

-
Frame-shiftENST00000559561ENST00000568104MEIS2chr15

37242525

-BBS2chr16

56545196

-
Frame-shiftENST00000561208ENST00000245157MEIS2chr15

37242525

-BBS2chr16

56545196

-
Frame-shiftENST00000561208ENST00000561951MEIS2chr15

37242525

-BBS2chr16

56545196

-
Frame-shiftENST00000561208ENST00000568104MEIS2chr15

37242525

-BBS2chr16

56545196

-
In-frameENST00000219869ENST00000245157MEIS2chr15

37242525

-BBS2chr16

56545196

-
In-frameENST00000219869ENST00000561951MEIS2chr15

37242525

-BBS2chr16

56545196

-
In-frameENST00000219869ENST00000568104MEIS2chr15

37242525

-BBS2chr16

56545196

-
In-frameENST00000338564ENST00000245157MEIS2chr15

37242525

-BBS2chr16

56545196

-
In-frameENST00000338564ENST00000561951MEIS2chr15

37242525

-BBS2chr16

56545196

-
In-frameENST00000338564ENST00000568104MEIS2chr15

37242525

-BBS2chr16

56545196

-
In-frameENST00000397624ENST00000245157MEIS2chr15

37242525

-BBS2chr16

56545196

-
In-frameENST00000397624ENST00000561951MEIS2chr15

37242525

-BBS2chr16

56545196

-
In-frameENST00000397624ENST00000568104MEIS2chr15

37242525

-BBS2chr16

56545196

-
In-frameENST00000424352ENST00000245157MEIS2chr15

37242525

-BBS2chr16

56545196

-
In-frameENST00000424352ENST00000561951MEIS2chr15

37242525

-BBS2chr16

56545196

-
In-frameENST00000424352ENST00000568104MEIS2chr15

37242525

-BBS2chr16

56545196

-
In-frameENST00000444725ENST00000245157MEIS2chr15

37242525

-BBS2chr16

56545196

-
In-frameENST00000444725ENST00000561951MEIS2chr15

37242525

-BBS2chr16

56545196

-
In-frameENST00000444725ENST00000568104MEIS2chr15

37242525

-BBS2chr16

56545196

-
In-frameENST00000559085ENST00000245157MEIS2chr15

37242525

-BBS2chr16

56545196

-
In-frameENST00000559085ENST00000561951MEIS2chr15

37242525

-BBS2chr16

56545196

-
In-frameENST00000559085ENST00000568104MEIS2chr15

37242525

-BBS2chr16

56545196

-
intron-3CDSENST00000559408ENST00000245157MEIS2chr15

37242525

-BBS2chr16

56545196

-
intron-3CDSENST00000559408ENST00000561951MEIS2chr15

37242525

-BBS2chr16

56545196

-
intron-3CDSENST00000559408ENST00000568104MEIS2chr15

37242525

-BBS2chr16

56545196

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000338564MEIS2chr1537242525-ENST00000568104BBS2chr1656545196-3523142413253106593
ENST00000338564MEIS2chr1537242525-ENST00000245157BBS2chr1656545196-3621142413253244639
ENST00000338564MEIS2chr1537242525-ENST00000561951BBS2chr1656545196-226914244321673413
ENST00000397624MEIS2chr1537242525-ENST00000568104BBS2chr1656545196-316310649652746593
ENST00000397624MEIS2chr1537242525-ENST00000245157BBS2chr1656545196-326110649652884639
ENST00000397624MEIS2chr1537242525-ENST00000561951BBS2chr1656545196-190910643511313320
ENST00000444725MEIS2chr1537242525-ENST00000568104BBS2chr1656545196-4113201419153696593
ENST00000444725MEIS2chr1537242525-ENST00000245157BBS2chr1656545196-4211201419153834639
ENST00000444725MEIS2chr1537242525-ENST00000561951BBS2chr1656545196-2859201410222263413
ENST00000559085MEIS2chr1537242525-ENST00000568104BBS2chr1656545196-316710689692750593
ENST00000559085MEIS2chr1537242525-ENST00000245157BBS2chr1656545196-326510689692888639
ENST00000559085MEIS2chr1537242525-ENST00000561951BBS2chr1656545196-191310681121317401
ENST00000219869MEIS2chr1537242525-ENST00000568104BBS2chr1656545196-29508517522533593
ENST00000219869MEIS2chr1537242525-ENST00000245157BBS2chr1656545196-30488517522671639
ENST00000219869MEIS2chr1537242525-ENST00000561951BBS2chr1656545196-16968511411470313
ENST00000424352MEIS2chr1537242525-ENST00000568104BBS2chr1656545196-4140204119423723593
ENST00000424352MEIS2chr1537242525-ENST00000245157BBS2chr1656545196-4238204119423861639
ENST00000424352MEIS2chr1537242525-ENST00000561951BBS2chr1656545196-2886204110492290413

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000338564ENST00000568104MEIS2chr1537242525-BBS2chr1656545196-0.0016995230.9983005
ENST00000338564ENST00000245157MEIS2chr1537242525-BBS2chr1656545196-0.0016268350.99837315
ENST00000338564ENST00000561951MEIS2chr1537242525-BBS2chr1656545196-0.0109829220.989017
ENST00000397624ENST00000568104MEIS2chr1537242525-BBS2chr1656545196-0.001871890.9981281
ENST00000397624ENST00000245157MEIS2chr1537242525-BBS2chr1656545196-0.0017764320.9982236
ENST00000397624ENST00000561951MEIS2chr1537242525-BBS2chr1656545196-0.0047507030.9952493
ENST00000444725ENST00000568104MEIS2chr1537242525-BBS2chr1656545196-0.0014087070.99859124
ENST00000444725ENST00000245157MEIS2chr1537242525-BBS2chr1656545196-0.0013168640.99868315
ENST00000444725ENST00000561951MEIS2chr1537242525-BBS2chr1656545196-0.0105189610.989481
ENST00000559085ENST00000568104MEIS2chr1537242525-BBS2chr1656545196-0.0018439080.99815613
ENST00000559085ENST00000245157MEIS2chr1537242525-BBS2chr1656545196-0.0017529850.998247
ENST00000559085ENST00000561951MEIS2chr1537242525-BBS2chr1656545196-0.0196822960.9803177
ENST00000219869ENST00000568104MEIS2chr1537242525-BBS2chr1656545196-0.0017955080.99820447
ENST00000219869ENST00000245157MEIS2chr1537242525-BBS2chr1656545196-0.0017202980.9982797
ENST00000219869ENST00000561951MEIS2chr1537242525-BBS2chr1656545196-0.0013593320.9986407
ENST00000424352ENST00000568104MEIS2chr1537242525-BBS2chr1656545196-0.0014605650.99853945
ENST00000424352ENST00000245157MEIS2chr1537242525-BBS2chr1656545196-0.0013542090.99864584
ENST00000424352ENST00000561951MEIS2chr1537242525-BBS2chr1656545196-0.0107828220.98921716

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Fusion Genomic Features for MEIS2-BBS2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MEIS2-BBS2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:37242525/chr16:56545196)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MEIS2

O14770

BBS2

Q9BXC9

FUNCTION: Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3 and isoform 4 can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5 cannot activate DRD1 transcription. {ECO:0000269|PubMed:10764806, ECO:0000269|PubMed:11279116, ECO:0000269|PubMed:21746878}.FUNCTION: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. {ECO:0000269|PubMed:17574030, ECO:0000269|PubMed:22072986}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMEIS2chr15:37242525chr16:56545196ENST00000338564-1013195_244325471.0Compositional biasNote=Ser/Thr-rich
HgeneMEIS2chr15:37242525chr16:56545196ENST00000338564-1013246_273325471.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMEIS2chr15:37242525chr16:56545196ENST00000338564-1013266_273325471.0Compositional biasNote=Poly-Asp
HgeneMEIS2chr15:37242525chr16:56545196ENST00000340545-913195_244312675.0Compositional biasNote=Ser/Thr-rich
HgeneMEIS2chr15:37242525chr16:56545196ENST00000340545-913246_273312675.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMEIS2chr15:37242525chr16:56545196ENST00000340545-913266_273312675.0Compositional biasNote=Poly-Asp
HgeneMEIS2chr15:37242525chr16:56545196ENST00000382766-912195_244325471.0Compositional biasNote=Ser/Thr-rich
HgeneMEIS2chr15:37242525chr16:56545196ENST00000382766-912246_273325471.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMEIS2chr15:37242525chr16:56545196ENST00000382766-912266_273325471.0Compositional biasNote=Poly-Asp
HgeneMEIS2chr15:37242525chr16:56545196ENST00000424352-913195_244325201.0Compositional biasNote=Ser/Thr-rich
HgeneMEIS2chr15:37242525chr16:56545196ENST00000424352-913246_273325201.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMEIS2chr15:37242525chr16:56545196ENST00000424352-913266_273325201.0Compositional biasNote=Poly-Asp
HgeneMEIS2chr15:37242525chr16:56545196ENST00000444725-913195_244325475.6666666666667Compositional biasNote=Ser/Thr-rich
HgeneMEIS2chr15:37242525chr16:56545196ENST00000444725-913246_273325475.6666666666667Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMEIS2chr15:37242525chr16:56545196ENST00000444725-913266_273325475.6666666666667Compositional biasNote=Poly-Asp
HgeneMEIS2chr15:37242525chr16:56545196ENST00000557796-913195_244312551.0Compositional biasNote=Ser/Thr-rich
HgeneMEIS2chr15:37242525chr16:56545196ENST00000557796-913246_273312551.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMEIS2chr15:37242525chr16:56545196ENST00000557796-913266_273312551.0Compositional biasNote=Poly-Asp
HgeneMEIS2chr15:37242525chr16:56545196ENST00000559085-812195_244312663.0Compositional biasNote=Ser/Thr-rich
HgeneMEIS2chr15:37242525chr16:56545196ENST00000559085-812246_273312663.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMEIS2chr15:37242525chr16:56545196ENST00000559085-812266_273312663.0Compositional biasNote=Poly-Asp
HgeneMEIS2chr15:37242525chr16:56545196ENST00000559561-912195_244325395.0Compositional biasNote=Ser/Thr-rich
HgeneMEIS2chr15:37242525chr16:56545196ENST00000559561-912246_273325395.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMEIS2chr15:37242525chr16:56545196ENST00000559561-912266_273325395.0Compositional biasNote=Poly-Asp
HgeneMEIS2chr15:37242525chr16:56545196ENST00000561208-912195_244325478.0Compositional biasNote=Ser/Thr-rich
HgeneMEIS2chr15:37242525chr16:56545196ENST00000561208-912246_273325478.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMEIS2chr15:37242525chr16:56545196ENST00000561208-912266_273325478.0Compositional biasNote=Poly-Asp
HgeneMEIS2chr15:37242525chr16:56545196ENST00000424352-913276_338325201.0DNA bindingHomeobox%3B TALE-type
HgeneMEIS2chr15:37242525chr16:56545196ENST00000424352-913340_477325201.0RegionNote=Transcriptional activation domain
TgeneBBS2chr15:37242525chr16:56545196ENST00000245157117325_369115722.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMEIS2chr15:37242525chr16:56545196ENST00000397620-913195_244237300.0Compositional biasNote=Ser/Thr-rich
HgeneMEIS2chr15:37242525chr16:56545196ENST00000397620-913246_273237300.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMEIS2chr15:37242525chr16:56545196ENST00000397620-913266_273237300.0Compositional biasNote=Poly-Asp
HgeneMEIS2chr15:37242525chr16:56545196ENST00000397624-812195_244237657.3333333333334Compositional biasNote=Ser/Thr-rich
HgeneMEIS2chr15:37242525chr16:56545196ENST00000397624-812246_273237657.3333333333334Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMEIS2chr15:37242525chr16:56545196ENST00000397624-812266_273237657.3333333333334Compositional biasNote=Poly-Asp
HgeneMEIS2chr15:37242525chr16:56545196ENST00000338564-1013276_338325471.0DNA bindingHomeobox%3B TALE-type
HgeneMEIS2chr15:37242525chr16:56545196ENST00000340545-913276_338312675.0DNA bindingHomeobox%3B TALE-type
HgeneMEIS2chr15:37242525chr16:56545196ENST00000382766-912276_338325471.0DNA bindingHomeobox%3B TALE-type
HgeneMEIS2chr15:37242525chr16:56545196ENST00000397620-913276_338237300.0DNA bindingHomeobox%3B TALE-type
HgeneMEIS2chr15:37242525chr16:56545196ENST00000397624-812276_338237657.3333333333334DNA bindingHomeobox%3B TALE-type
HgeneMEIS2chr15:37242525chr16:56545196ENST00000444725-913276_338325475.6666666666667DNA bindingHomeobox%3B TALE-type
HgeneMEIS2chr15:37242525chr16:56545196ENST00000557796-913276_338312551.0DNA bindingHomeobox%3B TALE-type
HgeneMEIS2chr15:37242525chr16:56545196ENST00000559085-812276_338312663.0DNA bindingHomeobox%3B TALE-type
HgeneMEIS2chr15:37242525chr16:56545196ENST00000559561-912276_338325395.0DNA bindingHomeobox%3B TALE-type
HgeneMEIS2chr15:37242525chr16:56545196ENST00000561208-912276_338325478.0DNA bindingHomeobox%3B TALE-type
HgeneMEIS2chr15:37242525chr16:56545196ENST00000338564-1013340_477325471.0RegionNote=Transcriptional activation domain
HgeneMEIS2chr15:37242525chr16:56545196ENST00000340545-913340_477312675.0RegionNote=Transcriptional activation domain
HgeneMEIS2chr15:37242525chr16:56545196ENST00000382766-912340_477325471.0RegionNote=Transcriptional activation domain
HgeneMEIS2chr15:37242525chr16:56545196ENST00000397620-913340_477237300.0RegionNote=Transcriptional activation domain
HgeneMEIS2chr15:37242525chr16:56545196ENST00000397624-812340_477237657.3333333333334RegionNote=Transcriptional activation domain
HgeneMEIS2chr15:37242525chr16:56545196ENST00000444725-913340_477325475.6666666666667RegionNote=Transcriptional activation domain
HgeneMEIS2chr15:37242525chr16:56545196ENST00000557796-913340_477312551.0RegionNote=Transcriptional activation domain
HgeneMEIS2chr15:37242525chr16:56545196ENST00000559085-812340_477312663.0RegionNote=Transcriptional activation domain
HgeneMEIS2chr15:37242525chr16:56545196ENST00000559561-912340_477325395.0RegionNote=Transcriptional activation domain
HgeneMEIS2chr15:37242525chr16:56545196ENST00000561208-912340_477325478.0RegionNote=Transcriptional activation domain


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Fusion Gene Sequence for MEIS2-BBS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>52891_52891_1_MEIS2-BBS2_MEIS2_chr15_37242525_ENST00000219869_BBS2_chr16_56545196_ENST00000245157_length(transcript)=3048nt_BP=851nt
ATTGGAGCGCAGACTGATGGCGCAAAGGTACGATGAGCTGCCCCATTACGGCGGGATGGACGGAGTAGGGGTTCCCGCTTCCATGTACGG
AGACCCTCACGCGCCGCGGCCGATCCCCCCGGTTCACCACCTGAACCACGGGCCGCCGCTCCACGCCACACAGCACTACGGCGCGCACGC
CCCGCACCCCAATGTCATGCCGGCCAGTATGGGATCCGCTGTCAACGACGCCTTGAAGCGGGACAAGGACGCGATCTATGGGTTCGCGCC
GAAAAGCCACTTTTTTCCTCAAATCCAGAGCTGGACAATTTGATGATACAAGCAATACAAGTACTAAGGTTTCATCTTTTGGAGTTAGAA
AAGGTCCACGAACTGTGCGATAACTTCTGCCACCGATACATTAGCTGTTTGAAGGGGAAAATGCCCATCGACCTCGTCATTGATGAAAGA
GACGGCAGCTCCAAGTCAGATCATGAAGAACTTTCAGGCTCCTCCACAAATCTCGCTGACCATAACCCTTCTTCTTGGCGAGACCACGAT
GATGCAACCTCAACCCACTCAGCAGGCACCCCAGGGCCCTCCAGTGGGGGCCATGCTTCCCAGAGCGGAGACAACAGCAGTGAGCAAGGG
GATGGTTTAGACAACAGTGTAGCTTCACCTGGTACAGGTGACGATGATGATCCGGATAAGGACAAAAAACGCCAGAAGAAAAGAGGCATT
TTCCCCAAAGTAGCAACAAATATCATGAGAGCATGGCTCTTCCAGCATCTCACACATCCGTACCCTTCCGAAGAGCAGAAGAAACAGTTA
GCGCAAGACACAGGACTTACAATTCTCCAAGTAAACAACTGGTAGCAGATGGGGCAAATGCAATTGTGCTGGGGACATTGGGAGACATTT
CTTCCCCTCTTGCGATTATTGGTGGCAATTGTGCTCTGCAAGGTTTCAATCATGAAGGAAGTGATCTCTTTTGGACGGTTACTGGAGACA
ATGTTAATTCCTTGGCCTTGTGTGACTTTGATGGTGATGGAAAGAAAGAGCTTCTTGTTGGATCTGAGGATTTTGATATCCGAGTTTTTA
AGGAAGATGAGATTGTGGCAGAAATGACAGAAACAGAGATAGTCACCTCTCTTTGTCCCATGTATGGCAGTCGATTTGGTTATGCCCTTT
CCAATGGCACAGTTGGAGTTTATGACAAAACATCCCGATACTGGAGAATTAAATCGAAAAATCATGCCATGAGCATTCATGCTTTTGACC
TTAATTCTGATGGAGTGAATGAACTGATAACTGGTTGGTCCAATGGGAAGGTTGATGCTCGAAGTGACCGAACTGGGGAGGTCATCTTTA
AGGACAATTTTTCTTCTGCAATTGCCGGTGTGGTAGAGGGAGATTACCGGATGGATGGCCACATACAGTTAATCTGCTGCTCAGTGGATG
GGGAAATCCGGGGCTACCTGCCTGGCACGGCTGAGATGAGGGGCAACCTCATGGACACCAGTGCAGAGCAGGACCTGATCCGAGAGCTGA
GTCAGAAGAAGCAGAATCTGTTGCTGGAACTCCGTAACTATGAGGAAAATGCCAAGGCTGAATTGGCCAGTCCACTGAACGAGGCTGATG
GGCATCGGGGCATAATCCCAGCCAATACCAGGCTCCACACCACGCTCTCAGTCAGCCTGGGGAATGAGACCCAAACTGCTCATACAGAAT
TACGCATTTCCACTTCTAATGACACCATCATCCGAGCAGTATTGATTTTTGCAGAAGGAATTTTTACAGGTGAAAGCCACGTGGTACATC
CCAGCATTCACAACCTCTCCAGTTCCATCTGCATCCCTATTGTGCCTCCCAAAGATGTCCCTGTGGATCTGCACTTGAAGGCATTCGTGG
GTTACAGAAGCAGCACCCAGTTTCATGTATTTGAATCGACAAGACAGCTCCCTCGATTCTCCATGTATGCGCTGACCAGCCTGGACCCTG
CCAGTGAGCCAATCAGTTATGTTAACTTTACCATTGCAGAACGGGCACAGAGGGTTGTTGTATGGCTCGGTCAGAACTTTCTGTTACCAG
AAGACACTCACATTCAGAATGCTCCATTTCAAGTGTGTTTCACATCTTTACGGAATGGCGGCCACCTGCATATAAAAATAAAACTTAGTG
GAGAGATCACTATAAATACTGATGATATTGATTTGGCTGGTGATATCATCCAGTCAATGGCATCATTTTTTGCTATTGAAGACCTTCAAG
TAGAAGCGGATTTTCCTGTCTATTTTGAGGAATTACGAAAGGTGCTAGTTAAGGTGGATGAATATCATTCAGTGCATCAGAAGCTCAGTG
CTGATATGGCTGATCATTCTAATTTGATCCGAAGTTTGCTGGTCGGAGCTGAGGATGCTCGTCTGATGAGGGACATGAAAACAATGAAGA
GTCGTTATATGGAACTCTATGACCTTAATAGAGACTTGCTAAATGGATATAAAATTCGCTGTAACAATCACACAGAGCTGTTGGGAAACC
TCAAAGCAGTAAATCAAGCAATTCAAAGAGCAGGTCGTCTGCGGGTTGGAAAACCAAAGAACCAGGTGATCACTGCTTGTCGGGATGCAA
TTCGAAGCAATAACATCAACACACTGTTCAAAATCATGCGAGTGGGGACAGCTTCTTCCTAGGTGAGGAAAATACAGGTCATGAAGTTCC
TGGCAAAGATTTTCTGTTAAAAACCTATGCTGGTTTGCTTTGGATCACACCCTGGTGAACCCCGGGTGCTAAGAATGAAAATAACCTTGG
TGAGTTGTACAAATTAAAGACAAAGAACTACATGTGAAGATAGACTTGCTTTCTATTTTTAAATCAGTAGTAGTACTGTTGCTGAATAAT
ACTAGGTTTTTATGGAATAGGATGAATGCTTTTGAAGTATTAGGGCTTCAGAGTCCAATTTTGCTTATTTATGGTATATAAATACATATT

>52891_52891_1_MEIS2-BBS2_MEIS2_chr15_37242525_ENST00000219869_BBS2_chr16_56545196_ENST00000245157_length(amino acids)=639AA_BP=33
MALPASHTSVPFRRAEETVSARHRTYNSPSKQLVADGANAIVLGTLGDISSPLAIIGGNCALQGFNHEGSDLFWTVTGDNVNSLALCDFD
GDGKKELLVGSEDFDIRVFKEDEIVAEMTETEIVTSLCPMYGSRFGYALSNGTVGVYDKTSRYWRIKSKNHAMSIHAFDLNSDGVNELIT
GWSNGKVDARSDRTGEVIFKDNFSSAIAGVVEGDYRMDGHIQLICCSVDGEIRGYLPGTAEMRGNLMDTSAEQDLIRELSQKKQNLLLEL
RNYEENAKAELASPLNEADGHRGIIPANTRLHTTLSVSLGNETQTAHTELRISTSNDTIIRAVLIFAEGIFTGESHVVHPSIHNLSSSIC
IPIVPPKDVPVDLHLKAFVGYRSSTQFHVFESTRQLPRFSMYALTSLDPASEPISYVNFTIAERAQRVVVWLGQNFLLPEDTHIQNAPFQ
VCFTSLRNGGHLHIKIKLSGEITINTDDIDLAGDIIQSMASFFAIEDLQVEADFPVYFEELRKVLVKVDEYHSVHQKLSADMADHSNLIR
SLLVGAEDARLMRDMKTMKSRYMELYDLNRDLLNGYKIRCNNHTELLGNLKAVNQAIQRAGRLRVGKPKNQVITACRDAIRSNNINTLFK

--------------------------------------------------------------
>52891_52891_2_MEIS2-BBS2_MEIS2_chr15_37242525_ENST00000219869_BBS2_chr16_56545196_ENST00000561951_length(transcript)=1696nt_BP=851nt
ATTGGAGCGCAGACTGATGGCGCAAAGGTACGATGAGCTGCCCCATTACGGCGGGATGGACGGAGTAGGGGTTCCCGCTTCCATGTACGG
AGACCCTCACGCGCCGCGGCCGATCCCCCCGGTTCACCACCTGAACCACGGGCCGCCGCTCCACGCCACACAGCACTACGGCGCGCACGC
CCCGCACCCCAATGTCATGCCGGCCAGTATGGGATCCGCTGTCAACGACGCCTTGAAGCGGGACAAGGACGCGATCTATGGGTTCGCGCC
GAAAAGCCACTTTTTTCCTCAAATCCAGAGCTGGACAATTTGATGATACAAGCAATACAAGTACTAAGGTTTCATCTTTTGGAGTTAGAA
AAGGTCCACGAACTGTGCGATAACTTCTGCCACCGATACATTAGCTGTTTGAAGGGGAAAATGCCCATCGACCTCGTCATTGATGAAAGA
GACGGCAGCTCCAAGTCAGATCATGAAGAACTTTCAGGCTCCTCCACAAATCTCGCTGACCATAACCCTTCTTCTTGGCGAGACCACGAT
GATGCAACCTCAACCCACTCAGCAGGCACCCCAGGGCCCTCCAGTGGGGGCCATGCTTCCCAGAGCGGAGACAACAGCAGTGAGCAAGGG
GATGGTTTAGACAACAGTGTAGCTTCACCTGGTACAGGTGACGATGATGATCCGGATAAGGACAAAAAACGCCAGAAGAAAAGAGGCATT
TTCCCCAAAGTAGCAACAAATATCATGAGAGCATGGCTCTTCCAGCATCTCACACATCCGTACCCTTCCGAAGAGCAGAAGAAACAGTTA
GCGCAAGACACAGGACTTACAATTCTCCAAGTAAACAACTGGATGGGGCAAATGCAATTGTGCTGGGGACATTGGGAGACATTTCTTCCC
CTCTTGCGATTATTGGTGGCAATTGTGCTCTGCAAGGTTTCAATCATGAAGGAAGTGATCTCTTTTGGACGGTTACTGGAGACAATGTTA
ATTCCTTGGCCTTGTGTGACTTTGATGGTGATGGAAAGAAAGAGCTTCTTGTTGGATCTGAGGATTTTGATATCCGAGTTTTTAAGGAAG
ATGAGATTGTGGCAGAAATGACAGAAACAGAGATAGTCACCTCTCTTTGTCCCATGTATGGCAGTCGATTTGGTTATGCCCTTTCCAATG
GCACAGTTGGAGTTTATGACAAAACATCCCGATACTGGAGAATTAAATCGAAAAATCATGCCATGAGCATTCATGCTTTTGACCTTAATT
CTGATGGAGTGAATGAACTGATAACTGGTTGGTCCAATGGGAAGGTTGATGCTCGAAGTGACCGAACTGGGGAGGTCATCTTTAAGGACA
ATTTTTCTTCTGCAATTGCCGGTGTGGTAGAGGGAGATTACCGGATGGATGGCCACATACAGTTAATCTGCTGCTCAGTGGATGGGGAAA
TCCGGGGCTACCTGCCTGGCACGGCTGAGATGAGGGGCAACCTCATGGACACCAGTGCAGAGCAGGACCTGATCCGAGAGCTGAGTCAGA
AGAAGCAGAATCTGTTGCTGGAACTCCGTAACTATGAGGAAAATGCCAAGAACAATACTTCAAAAATGTTAAAGTCATGATGGGATACAG

>52891_52891_2_MEIS2-BBS2_MEIS2_chr15_37242525_ENST00000219869_BBS2_chr16_56545196_ENST00000561951_length(amino acids)=313AA_BP=1
MYVAIHPVISLYHTGNCRRKIVLKDDLPSSVTSSINLPIGPTSYQFIHSIRIKVKSMNAHGMIFRFNSPVSGCFVINSNCAIGKGITKST
AIHGTKRGDYLCFCHFCHNLIFLKNSDIKILRSNKKLFLSITIKVTQGQGINIVSSNRPKEITSFMIETLQSTIATNNRKRGRNVSQCPQ
HNCICPIQLFTWRIVSPVSCANCFFCSSEGYGCVRCWKSHALMIFVATLGKMPLFFWRFLSLSGSSSSPVPGEATLLSKPSPCSLLLSPL

--------------------------------------------------------------
>52891_52891_3_MEIS2-BBS2_MEIS2_chr15_37242525_ENST00000219869_BBS2_chr16_56545196_ENST00000568104_length(transcript)=2950nt_BP=851nt
ATTGGAGCGCAGACTGATGGCGCAAAGGTACGATGAGCTGCCCCATTACGGCGGGATGGACGGAGTAGGGGTTCCCGCTTCCATGTACGG
AGACCCTCACGCGCCGCGGCCGATCCCCCCGGTTCACCACCTGAACCACGGGCCGCCGCTCCACGCCACACAGCACTACGGCGCGCACGC
CCCGCACCCCAATGTCATGCCGGCCAGTATGGGATCCGCTGTCAACGACGCCTTGAAGCGGGACAAGGACGCGATCTATGGGTTCGCGCC
GAAAAGCCACTTTTTTCCTCAAATCCAGAGCTGGACAATTTGATGATACAAGCAATACAAGTACTAAGGTTTCATCTTTTGGAGTTAGAA
AAGGTCCACGAACTGTGCGATAACTTCTGCCACCGATACATTAGCTGTTTGAAGGGGAAAATGCCCATCGACCTCGTCATTGATGAAAGA
GACGGCAGCTCCAAGTCAGATCATGAAGAACTTTCAGGCTCCTCCACAAATCTCGCTGACCATAACCCTTCTTCTTGGCGAGACCACGAT
GATGCAACCTCAACCCACTCAGCAGGCACCCCAGGGCCCTCCAGTGGGGGCCATGCTTCCCAGAGCGGAGACAACAGCAGTGAGCAAGGG
GATGGTTTAGACAACAGTGTAGCTTCACCTGGTACAGGTGACGATGATGATCCGGATAAGGACAAAAAACGCCAGAAGAAAAGAGGCATT
TTCCCCAAAGTAGCAACAAATATCATGAGAGCATGGCTCTTCCAGCATCTCACACATCCGTACCCTTCCGAAGAGCAGAAGAAACAGTTA
GCGCAAGACACAGGACTTACAATTCTCCAAGTAAACAACTGGTAGCAGATGGGGCAAATGCAATTGTGCTGGGGACATTGGGAGACATTT
CTTCCCCTCTTGCGATTATTGGTGGCAATTGTGCTCTGCAAGGTTTCAATCATGAAGGAAGTGATCTCTTTTGGACGGTTACTGGAGACA
ATGTTAATTCCTTGGCCTTGTGTGACTTTGATGGTGATGGAAAGAAAGAGCTTCTTGTTGGATCTGAGGATTTTGATATCCGAGTTTTTA
AGGAAGATGAGATTGTGGCAGAAATGACAGAAACAGAGATAGTCACCTCTCTTTGTCCCATGTATGGCAGTCGATTTGGTTATGCCCTTT
CCAATGGCACAGTTGGAGTTTATGACAAAACATCCCGATACTGGAGAATTAAATCGAAAAATCATGCCATGAGCATTCATGCTTTTGACC
TTAATTCTGATGGAGTGAATGAACTGATAACTGGTTGGTCCAATGGGAAGGTTGATGCTCGAAGTGACCGAACTGGGGAGGTCATCTTTA
AGGACAATTTTTCTTCTGCAATTGCCGGTGTGGTAGAGGGAGATTACCGGATGGATGGCCACATACAGTTAATCTGCTGCTCAGTGGATG
GGGAAATCCGGGGCTACCTGCCTGGCACGGCTGAGATGAGGGGCAACCTCATGGACACCAGTGCAGAGCAGGACCTGATCCGAGAGCTGA
GTCAGAAGAAGCAGAATCTGTTGCTGGAACTCCGTAACTATGAGGAAAATGCCAAGGCTGAATTGGCCAGTCCACTGAACGAGGCTGATG
GGCATCGGGGCATAATCCCAGCCAATACCAGGCTCCACACCACGCTCTCAGTCAGCCTGGGGAATGAGACCCAAACTGCTCATACAGAAT
TACGCATTTCCACTTCTAATGACACCATCATCCGAGCAGTATTGATTTTTGCAGAAGGAATTTTTACAGGTGAAAGCCACGTGGTACATC
CCAGCATTCACAACCTCTCCAGTTCCATCTGCATCCCTATTGTGCCTCCCAAAGATGTCCCTGTGGATCTGCACTTGAAGGCATTCGTGG
GTTACAGAAGCAGCACCCAGTTTCATGTATTTGAATCGACAAGACAGCTCCCTCGATTCTCCATGTATGCGCTGACCAGCCTGGACCCTG
CCAGTGAGCCAATCAGTTATGTTAACTTTACCATTGCAGAACGGGCACAGAGGGTTGTTGTATGGCTCGGTCAGAACTTTCTGTTACCAG
AAGACACTCACATTCAGAATGCTCCATTTCAAGTGTGTTTCACATCTTTACGGAATGGCGGCCACCTGCATATAAAAATAAAACTTAGTG
GAGAGGTGGATGAATATCATTCAGTGCATCAGAAGCTCAGTGCTGATATGGCTGATCATTCTAATTTGATCCGAAGTTTGCTGGTCGGAG
CTGAGGATGCTCGTCTGATGAGGGACATGAAAACAATGAAGAGTCGTTATATGGAACTCTATGACCTTAATAGAGACTTGCTAAATGGAT
ATAAAATTCGCTGTAACAATCACACAGAGCTGTTGGGAAACCTCAAAGCAGTAAATCAAGCAATTCAAAGAGCAGGTCGTCTGCGGGTTG
GAAAACCAAAGAACCAGGTGATCACTGCTTGTCGGGATGCAATTCGAAGCAATAACATCAACACACTGTTCAAAATCATGCGAGTGGGGA
CAGCTTCTTCCTAGGTGAGGAAAATACAGGTCATGAAGTTCCTGGCAAAGATTTTCTGTTAAAAACCTATGCTGGTTTGCTTTGGATCAC
ACCCTGGTGAACCCCGGGTGCTAAGAATGAAAATAACCTTGGTGAGTTGTACAAATTAAAGACAAAGAACTACATGTGAAGATAGACTTG
CTTTCTATTTTTAAATCAGTAGTAGTACTGTTGCTGAATAATACTAGGTTTTTATGGAATAGGATGAATGCTTTTGAAGTATTAGGGCTT
CAGAGTCCAATTTTGCTTATTTATGGTATATAAATACATATTTTTTTCTTGAAATTGCAATTGAGTTTGTACTTTTCAAATAGATTATCT

>52891_52891_3_MEIS2-BBS2_MEIS2_chr15_37242525_ENST00000219869_BBS2_chr16_56545196_ENST00000568104_length(amino acids)=593AA_BP=33
MALPASHTSVPFRRAEETVSARHRTYNSPSKQLVADGANAIVLGTLGDISSPLAIIGGNCALQGFNHEGSDLFWTVTGDNVNSLALCDFD
GDGKKELLVGSEDFDIRVFKEDEIVAEMTETEIVTSLCPMYGSRFGYALSNGTVGVYDKTSRYWRIKSKNHAMSIHAFDLNSDGVNELIT
GWSNGKVDARSDRTGEVIFKDNFSSAIAGVVEGDYRMDGHIQLICCSVDGEIRGYLPGTAEMRGNLMDTSAEQDLIRELSQKKQNLLLEL
RNYEENAKAELASPLNEADGHRGIIPANTRLHTTLSVSLGNETQTAHTELRISTSNDTIIRAVLIFAEGIFTGESHVVHPSIHNLSSSIC
IPIVPPKDVPVDLHLKAFVGYRSSTQFHVFESTRQLPRFSMYALTSLDPASEPISYVNFTIAERAQRVVVWLGQNFLLPEDTHIQNAPFQ
VCFTSLRNGGHLHIKIKLSGEVDEYHSVHQKLSADMADHSNLIRSLLVGAEDARLMRDMKTMKSRYMELYDLNRDLLNGYKIRCNNHTEL

--------------------------------------------------------------
>52891_52891_4_MEIS2-BBS2_MEIS2_chr15_37242525_ENST00000338564_BBS2_chr16_56545196_ENST00000245157_length(transcript)=3621nt_BP=1424nt
ACCGCTTGGAGGGAGTGTGCTCTGAGTTAAGCTGGTCTCTTCTGGTCCTGGAAAAAAATGAGTATTGACAAGGTTGCTGGATCTGCGCAG
AAAAGAAAGTGCCACTTAATAAAAAATTTAGCCCGGCAGTGGTACCGTCTGCAGAGCTTGCTGCCCTTGGACGTTAGCAGGAAGCCTTCG
GGGTGCTGTAATCGGCGGGCAGAGGAGAGGGAGGCCGCGGAATTAAAAGGAACAAAAGCTAGAGCGCCATGCCAAACGTCCCCGGCAAGA
CCCAGTTAGGCAGGAGCCGGGAGTGATGGGAAAATGAACTAGAACATATTGGAGAATTGGGAGAAGTCTCTTTGGTTTGGAAAAAAAAAA
AAGGAATCTTCAGCCTAGATCACTTTCTTATCCGGACTGGGATATTAAATATACGACACATCCAGGAGTTTATTGGAGCGCAGACTGATG
GCGCAAAGGTACGATGAGCTGCCCCATTACGGCGGGATGGACGGAGTAGGGGTTCCCGCTTCCATGTACGGAGACCCTCACGCGCCGCGG
CCGATCCCCCCGGTTCACCACCTGAACCACGGGCCGCCGCTCCACGCCACACAGCACTACGGCGCGCACGCCCCGCACCCCAATGTCATG
CCGGCCAGTATGGGATCCGCTGTCAACGACGCCTTGAAGCGGGACAAGGACGCGATCTATGGGCACCCGTTGTTTCCTCTGTTAGCTCTG
GTCTTTGAGAAGTGCGAGCTGGCGACCTGCACTCCCCGGGAACCTGGAGTGGCTGGCGGAGACGTCTGCTCCTCCGACTCCTTCAACGAG
GACATCGCGGTCTTCGCCAAGCAGGTTCGCGCCGAAAAGCCACTTTTTTCCTCAAATCCAGAGCTGGACAATTTGATGATACAAGCAATA
CAAGTACTAAGGTTTCATCTTTTGGAGTTAGAAAAGGTCCACGAACTGTGCGATAACTTCTGCCACCGATACATTAGCTGTTTGAAGGGG
AAAATGCCCATCGACCTCGTCATTGATGAAAGAGACGGCAGCTCCAAGTCAGATCATGAAGAACTTTCAGGCTCCTCCACAAATCTCGCT
GACCATAACCCTTCTTCTTGGCGAGACCACGATGATGCAACCTCAACCCACTCAGCAGGCACCCCAGGGCCCTCCAGTGGGGGCCATGCT
TCCCAGAGCGGAGACAACAGCAGTGAGCAAGGGGATGGTTTAGACAACAGTGTAGCTTCACCTGGTACAGGTGACGATGATGATCCGGAT
AAGGACAAAAAACGCCAGAAGAAAAGAGGCATTTTCCCCAAAGTAGCAACAAATATCATGAGAGCATGGCTCTTCCAGCATCTCACACAT
CCGTACCCTTCCGAAGAGCAGAAGAAACAGTTAGCGCAAGACACAGGACTTACAATTCTCCAAGTAAACAACTGGTAGCAGATGGGGCAA
ATGCAATTGTGCTGGGGACATTGGGAGACATTTCTTCCCCTCTTGCGATTATTGGTGGCAATTGTGCTCTGCAAGGTTTCAATCATGAAG
GAAGTGATCTCTTTTGGACGGTTACTGGAGACAATGTTAATTCCTTGGCCTTGTGTGACTTTGATGGTGATGGAAAGAAAGAGCTTCTTG
TTGGATCTGAGGATTTTGATATCCGAGTTTTTAAGGAAGATGAGATTGTGGCAGAAATGACAGAAACAGAGATAGTCACCTCTCTTTGTC
CCATGTATGGCAGTCGATTTGGTTATGCCCTTTCCAATGGCACAGTTGGAGTTTATGACAAAACATCCCGATACTGGAGAATTAAATCGA
AAAATCATGCCATGAGCATTCATGCTTTTGACCTTAATTCTGATGGAGTGAATGAACTGATAACTGGTTGGTCCAATGGGAAGGTTGATG
CTCGAAGTGACCGAACTGGGGAGGTCATCTTTAAGGACAATTTTTCTTCTGCAATTGCCGGTGTGGTAGAGGGAGATTACCGGATGGATG
GCCACATACAGTTAATCTGCTGCTCAGTGGATGGGGAAATCCGGGGCTACCTGCCTGGCACGGCTGAGATGAGGGGCAACCTCATGGACA
CCAGTGCAGAGCAGGACCTGATCCGAGAGCTGAGTCAGAAGAAGCAGAATCTGTTGCTGGAACTCCGTAACTATGAGGAAAATGCCAAGG
CTGAATTGGCCAGTCCACTGAACGAGGCTGATGGGCATCGGGGCATAATCCCAGCCAATACCAGGCTCCACACCACGCTCTCAGTCAGCC
TGGGGAATGAGACCCAAACTGCTCATACAGAATTACGCATTTCCACTTCTAATGACACCATCATCCGAGCAGTATTGATTTTTGCAGAAG
GAATTTTTACAGGTGAAAGCCACGTGGTACATCCCAGCATTCACAACCTCTCCAGTTCCATCTGCATCCCTATTGTGCCTCCCAAAGATG
TCCCTGTGGATCTGCACTTGAAGGCATTCGTGGGTTACAGAAGCAGCACCCAGTTTCATGTATTTGAATCGACAAGACAGCTCCCTCGAT
TCTCCATGTATGCGCTGACCAGCCTGGACCCTGCCAGTGAGCCAATCAGTTATGTTAACTTTACCATTGCAGAACGGGCACAGAGGGTTG
TTGTATGGCTCGGTCAGAACTTTCTGTTACCAGAAGACACTCACATTCAGAATGCTCCATTTCAAGTGTGTTTCACATCTTTACGGAATG
GCGGCCACCTGCATATAAAAATAAAACTTAGTGGAGAGATCACTATAAATACTGATGATATTGATTTGGCTGGTGATATCATCCAGTCAA
TGGCATCATTTTTTGCTATTGAAGACCTTCAAGTAGAAGCGGATTTTCCTGTCTATTTTGAGGAATTACGAAAGGTGCTAGTTAAGGTGG
ATGAATATCATTCAGTGCATCAGAAGCTCAGTGCTGATATGGCTGATCATTCTAATTTGATCCGAAGTTTGCTGGTCGGAGCTGAGGATG
CTCGTCTGATGAGGGACATGAAAACAATGAAGAGTCGTTATATGGAACTCTATGACCTTAATAGAGACTTGCTAAATGGATATAAAATTC
GCTGTAACAATCACACAGAGCTGTTGGGAAACCTCAAAGCAGTAAATCAAGCAATTCAAAGAGCAGGTCGTCTGCGGGTTGGAAAACCAA
AGAACCAGGTGATCACTGCTTGTCGGGATGCAATTCGAAGCAATAACATCAACACACTGTTCAAAATCATGCGAGTGGGGACAGCTTCTT
CCTAGGTGAGGAAAATACAGGTCATGAAGTTCCTGGCAAAGATTTTCTGTTAAAAACCTATGCTGGTTTGCTTTGGATCACACCCTGGTG
AACCCCGGGTGCTAAGAATGAAAATAACCTTGGTGAGTTGTACAAATTAAAGACAAAGAACTACATGTGAAGATAGACTTGCTTTCTATT
TTTAAATCAGTAGTAGTACTGTTGCTGAATAATACTAGGTTTTTATGGAATAGGATGAATGCTTTTGAAGTATTAGGGCTTCAGAGTCCA
ATTTTGCTTATTTATGGTATATAAATACATATTTTTTTCTTGAAATTGCAATTGAGTTTGTACTTTTCAAATAGATTATCTACTTTTTCA

>52891_52891_4_MEIS2-BBS2_MEIS2_chr15_37242525_ENST00000338564_BBS2_chr16_56545196_ENST00000245157_length(amino acids)=639AA_BP=33
MALPASHTSVPFRRAEETVSARHRTYNSPSKQLVADGANAIVLGTLGDISSPLAIIGGNCALQGFNHEGSDLFWTVTGDNVNSLALCDFD
GDGKKELLVGSEDFDIRVFKEDEIVAEMTETEIVTSLCPMYGSRFGYALSNGTVGVYDKTSRYWRIKSKNHAMSIHAFDLNSDGVNELIT
GWSNGKVDARSDRTGEVIFKDNFSSAIAGVVEGDYRMDGHIQLICCSVDGEIRGYLPGTAEMRGNLMDTSAEQDLIRELSQKKQNLLLEL
RNYEENAKAELASPLNEADGHRGIIPANTRLHTTLSVSLGNETQTAHTELRISTSNDTIIRAVLIFAEGIFTGESHVVHPSIHNLSSSIC
IPIVPPKDVPVDLHLKAFVGYRSSTQFHVFESTRQLPRFSMYALTSLDPASEPISYVNFTIAERAQRVVVWLGQNFLLPEDTHIQNAPFQ
VCFTSLRNGGHLHIKIKLSGEITINTDDIDLAGDIIQSMASFFAIEDLQVEADFPVYFEELRKVLVKVDEYHSVHQKLSADMADHSNLIR
SLLVGAEDARLMRDMKTMKSRYMELYDLNRDLLNGYKIRCNNHTELLGNLKAVNQAIQRAGRLRVGKPKNQVITACRDAIRSNNINTLFK

--------------------------------------------------------------
>52891_52891_5_MEIS2-BBS2_MEIS2_chr15_37242525_ENST00000338564_BBS2_chr16_56545196_ENST00000561951_length(transcript)=2269nt_BP=1424nt
ACCGCTTGGAGGGAGTGTGCTCTGAGTTAAGCTGGTCTCTTCTGGTCCTGGAAAAAAATGAGTATTGACAAGGTTGCTGGATCTGCGCAG
AAAAGAAAGTGCCACTTAATAAAAAATTTAGCCCGGCAGTGGTACCGTCTGCAGAGCTTGCTGCCCTTGGACGTTAGCAGGAAGCCTTCG
GGGTGCTGTAATCGGCGGGCAGAGGAGAGGGAGGCCGCGGAATTAAAAGGAACAAAAGCTAGAGCGCCATGCCAAACGTCCCCGGCAAGA
CCCAGTTAGGCAGGAGCCGGGAGTGATGGGAAAATGAACTAGAACATATTGGAGAATTGGGAGAAGTCTCTTTGGTTTGGAAAAAAAAAA
AAGGAATCTTCAGCCTAGATCACTTTCTTATCCGGACTGGGATATTAAATATACGACACATCCAGGAGTTTATTGGAGCGCAGACTGATG
GCGCAAAGGTACGATGAGCTGCCCCATTACGGCGGGATGGACGGAGTAGGGGTTCCCGCTTCCATGTACGGAGACCCTCACGCGCCGCGG
CCGATCCCCCCGGTTCACCACCTGAACCACGGGCCGCCGCTCCACGCCACACAGCACTACGGCGCGCACGCCCCGCACCCCAATGTCATG
CCGGCCAGTATGGGATCCGCTGTCAACGACGCCTTGAAGCGGGACAAGGACGCGATCTATGGGCACCCGTTGTTTCCTCTGTTAGCTCTG
GTCTTTGAGAAGTGCGAGCTGGCGACCTGCACTCCCCGGGAACCTGGAGTGGCTGGCGGAGACGTCTGCTCCTCCGACTCCTTCAACGAG
GACATCGCGGTCTTCGCCAAGCAGGTTCGCGCCGAAAAGCCACTTTTTTCCTCAAATCCAGAGCTGGACAATTTGATGATACAAGCAATA
CAAGTACTAAGGTTTCATCTTTTGGAGTTAGAAAAGGTCCACGAACTGTGCGATAACTTCTGCCACCGATACATTAGCTGTTTGAAGGGG
AAAATGCCCATCGACCTCGTCATTGATGAAAGAGACGGCAGCTCCAAGTCAGATCATGAAGAACTTTCAGGCTCCTCCACAAATCTCGCT
GACCATAACCCTTCTTCTTGGCGAGACCACGATGATGCAACCTCAACCCACTCAGCAGGCACCCCAGGGCCCTCCAGTGGGGGCCATGCT
TCCCAGAGCGGAGACAACAGCAGTGAGCAAGGGGATGGTTTAGACAACAGTGTAGCTTCACCTGGTACAGGTGACGATGATGATCCGGAT
AAGGACAAAAAACGCCAGAAGAAAAGAGGCATTTTCCCCAAAGTAGCAACAAATATCATGAGAGCATGGCTCTTCCAGCATCTCACACAT
CCGTACCCTTCCGAAGAGCAGAAGAAACAGTTAGCGCAAGACACAGGACTTACAATTCTCCAAGTAAACAACTGGATGGGGCAAATGCAA
TTGTGCTGGGGACATTGGGAGACATTTCTTCCCCTCTTGCGATTATTGGTGGCAATTGTGCTCTGCAAGGTTTCAATCATGAAGGAAGTG
ATCTCTTTTGGACGGTTACTGGAGACAATGTTAATTCCTTGGCCTTGTGTGACTTTGATGGTGATGGAAAGAAAGAGCTTCTTGTTGGAT
CTGAGGATTTTGATATCCGAGTTTTTAAGGAAGATGAGATTGTGGCAGAAATGACAGAAACAGAGATAGTCACCTCTCTTTGTCCCATGT
ATGGCAGTCGATTTGGTTATGCCCTTTCCAATGGCACAGTTGGAGTTTATGACAAAACATCCCGATACTGGAGAATTAAATCGAAAAATC
ATGCCATGAGCATTCATGCTTTTGACCTTAATTCTGATGGAGTGAATGAACTGATAACTGGTTGGTCCAATGGGAAGGTTGATGCTCGAA
GTGACCGAACTGGGGAGGTCATCTTTAAGGACAATTTTTCTTCTGCAATTGCCGGTGTGGTAGAGGGAGATTACCGGATGGATGGCCACA
TACAGTTAATCTGCTGCTCAGTGGATGGGGAAATCCGGGGCTACCTGCCTGGCACGGCTGAGATGAGGGGCAACCTCATGGACACCAGTG
CAGAGCAGGACCTGATCCGAGAGCTGAGTCAGAAGAAGCAGAATCTGTTGCTGGAACTCCGTAACTATGAGGAAAATGCCAAGAACAATA
CTTCAAAAATGTTAAAGTCATGATGGGATACAGTGGACCATACCCATAGAAAGATGCAAGGGTATTTTCCCACAGGGCCAGATAGAGCAA

>52891_52891_5_MEIS2-BBS2_MEIS2_chr15_37242525_ENST00000338564_BBS2_chr16_56545196_ENST00000561951_length(amino acids)=413AA_BP=331
MERRLMAQRYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNVMPASMGSAVNDALKRDKDAIYGHPL
FPLLALVFEKCELATCTPREPGVAGGDVCSSDSFNEDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRY
ISCLKGKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGHASQSGDNSSEQGDGLDNSVASPGTG
DDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWMGQMQLCWGHWETFLPLLRLLVAIVLCKV

--------------------------------------------------------------
>52891_52891_6_MEIS2-BBS2_MEIS2_chr15_37242525_ENST00000338564_BBS2_chr16_56545196_ENST00000568104_length(transcript)=3523nt_BP=1424nt
ACCGCTTGGAGGGAGTGTGCTCTGAGTTAAGCTGGTCTCTTCTGGTCCTGGAAAAAAATGAGTATTGACAAGGTTGCTGGATCTGCGCAG
AAAAGAAAGTGCCACTTAATAAAAAATTTAGCCCGGCAGTGGTACCGTCTGCAGAGCTTGCTGCCCTTGGACGTTAGCAGGAAGCCTTCG
GGGTGCTGTAATCGGCGGGCAGAGGAGAGGGAGGCCGCGGAATTAAAAGGAACAAAAGCTAGAGCGCCATGCCAAACGTCCCCGGCAAGA
CCCAGTTAGGCAGGAGCCGGGAGTGATGGGAAAATGAACTAGAACATATTGGAGAATTGGGAGAAGTCTCTTTGGTTTGGAAAAAAAAAA
AAGGAATCTTCAGCCTAGATCACTTTCTTATCCGGACTGGGATATTAAATATACGACACATCCAGGAGTTTATTGGAGCGCAGACTGATG
GCGCAAAGGTACGATGAGCTGCCCCATTACGGCGGGATGGACGGAGTAGGGGTTCCCGCTTCCATGTACGGAGACCCTCACGCGCCGCGG
CCGATCCCCCCGGTTCACCACCTGAACCACGGGCCGCCGCTCCACGCCACACAGCACTACGGCGCGCACGCCCCGCACCCCAATGTCATG
CCGGCCAGTATGGGATCCGCTGTCAACGACGCCTTGAAGCGGGACAAGGACGCGATCTATGGGCACCCGTTGTTTCCTCTGTTAGCTCTG
GTCTTTGAGAAGTGCGAGCTGGCGACCTGCACTCCCCGGGAACCTGGAGTGGCTGGCGGAGACGTCTGCTCCTCCGACTCCTTCAACGAG
GACATCGCGGTCTTCGCCAAGCAGGTTCGCGCCGAAAAGCCACTTTTTTCCTCAAATCCAGAGCTGGACAATTTGATGATACAAGCAATA
CAAGTACTAAGGTTTCATCTTTTGGAGTTAGAAAAGGTCCACGAACTGTGCGATAACTTCTGCCACCGATACATTAGCTGTTTGAAGGGG
AAAATGCCCATCGACCTCGTCATTGATGAAAGAGACGGCAGCTCCAAGTCAGATCATGAAGAACTTTCAGGCTCCTCCACAAATCTCGCT
GACCATAACCCTTCTTCTTGGCGAGACCACGATGATGCAACCTCAACCCACTCAGCAGGCACCCCAGGGCCCTCCAGTGGGGGCCATGCT
TCCCAGAGCGGAGACAACAGCAGTGAGCAAGGGGATGGTTTAGACAACAGTGTAGCTTCACCTGGTACAGGTGACGATGATGATCCGGAT
AAGGACAAAAAACGCCAGAAGAAAAGAGGCATTTTCCCCAAAGTAGCAACAAATATCATGAGAGCATGGCTCTTCCAGCATCTCACACAT
CCGTACCCTTCCGAAGAGCAGAAGAAACAGTTAGCGCAAGACACAGGACTTACAATTCTCCAAGTAAACAACTGGTAGCAGATGGGGCAA
ATGCAATTGTGCTGGGGACATTGGGAGACATTTCTTCCCCTCTTGCGATTATTGGTGGCAATTGTGCTCTGCAAGGTTTCAATCATGAAG
GAAGTGATCTCTTTTGGACGGTTACTGGAGACAATGTTAATTCCTTGGCCTTGTGTGACTTTGATGGTGATGGAAAGAAAGAGCTTCTTG
TTGGATCTGAGGATTTTGATATCCGAGTTTTTAAGGAAGATGAGATTGTGGCAGAAATGACAGAAACAGAGATAGTCACCTCTCTTTGTC
CCATGTATGGCAGTCGATTTGGTTATGCCCTTTCCAATGGCACAGTTGGAGTTTATGACAAAACATCCCGATACTGGAGAATTAAATCGA
AAAATCATGCCATGAGCATTCATGCTTTTGACCTTAATTCTGATGGAGTGAATGAACTGATAACTGGTTGGTCCAATGGGAAGGTTGATG
CTCGAAGTGACCGAACTGGGGAGGTCATCTTTAAGGACAATTTTTCTTCTGCAATTGCCGGTGTGGTAGAGGGAGATTACCGGATGGATG
GCCACATACAGTTAATCTGCTGCTCAGTGGATGGGGAAATCCGGGGCTACCTGCCTGGCACGGCTGAGATGAGGGGCAACCTCATGGACA
CCAGTGCAGAGCAGGACCTGATCCGAGAGCTGAGTCAGAAGAAGCAGAATCTGTTGCTGGAACTCCGTAACTATGAGGAAAATGCCAAGG
CTGAATTGGCCAGTCCACTGAACGAGGCTGATGGGCATCGGGGCATAATCCCAGCCAATACCAGGCTCCACACCACGCTCTCAGTCAGCC
TGGGGAATGAGACCCAAACTGCTCATACAGAATTACGCATTTCCACTTCTAATGACACCATCATCCGAGCAGTATTGATTTTTGCAGAAG
GAATTTTTACAGGTGAAAGCCACGTGGTACATCCCAGCATTCACAACCTCTCCAGTTCCATCTGCATCCCTATTGTGCCTCCCAAAGATG
TCCCTGTGGATCTGCACTTGAAGGCATTCGTGGGTTACAGAAGCAGCACCCAGTTTCATGTATTTGAATCGACAAGACAGCTCCCTCGAT
TCTCCATGTATGCGCTGACCAGCCTGGACCCTGCCAGTGAGCCAATCAGTTATGTTAACTTTACCATTGCAGAACGGGCACAGAGGGTTG
TTGTATGGCTCGGTCAGAACTTTCTGTTACCAGAAGACACTCACATTCAGAATGCTCCATTTCAAGTGTGTTTCACATCTTTACGGAATG
GCGGCCACCTGCATATAAAAATAAAACTTAGTGGAGAGGTGGATGAATATCATTCAGTGCATCAGAAGCTCAGTGCTGATATGGCTGATC
ATTCTAATTTGATCCGAAGTTTGCTGGTCGGAGCTGAGGATGCTCGTCTGATGAGGGACATGAAAACAATGAAGAGTCGTTATATGGAAC
TCTATGACCTTAATAGAGACTTGCTAAATGGATATAAAATTCGCTGTAACAATCACACAGAGCTGTTGGGAAACCTCAAAGCAGTAAATC
AAGCAATTCAAAGAGCAGGTCGTCTGCGGGTTGGAAAACCAAAGAACCAGGTGATCACTGCTTGTCGGGATGCAATTCGAAGCAATAACA
TCAACACACTGTTCAAAATCATGCGAGTGGGGACAGCTTCTTCCTAGGTGAGGAAAATACAGGTCATGAAGTTCCTGGCAAAGATTTTCT
GTTAAAAACCTATGCTGGTTTGCTTTGGATCACACCCTGGTGAACCCCGGGTGCTAAGAATGAAAATAACCTTGGTGAGTTGTACAAATT
AAAGACAAAGAACTACATGTGAAGATAGACTTGCTTTCTATTTTTAAATCAGTAGTAGTACTGTTGCTGAATAATACTAGGTTTTTATGG
AATAGGATGAATGCTTTTGAAGTATTAGGGCTTCAGAGTCCAATTTTGCTTATTTATGGTATATAAATACATATTTTTTTCTTGAAATTG
CAATTGAGTTTGTACTTTTCAAATAGATTATCTACTTTTTCATTAAAATGTAAAGATGTTAAACTTTGTGTTGATTGATTATAAAATCAC

>52891_52891_6_MEIS2-BBS2_MEIS2_chr15_37242525_ENST00000338564_BBS2_chr16_56545196_ENST00000568104_length(amino acids)=593AA_BP=33
MALPASHTSVPFRRAEETVSARHRTYNSPSKQLVADGANAIVLGTLGDISSPLAIIGGNCALQGFNHEGSDLFWTVTGDNVNSLALCDFD
GDGKKELLVGSEDFDIRVFKEDEIVAEMTETEIVTSLCPMYGSRFGYALSNGTVGVYDKTSRYWRIKSKNHAMSIHAFDLNSDGVNELIT
GWSNGKVDARSDRTGEVIFKDNFSSAIAGVVEGDYRMDGHIQLICCSVDGEIRGYLPGTAEMRGNLMDTSAEQDLIRELSQKKQNLLLEL
RNYEENAKAELASPLNEADGHRGIIPANTRLHTTLSVSLGNETQTAHTELRISTSNDTIIRAVLIFAEGIFTGESHVVHPSIHNLSSSIC
IPIVPPKDVPVDLHLKAFVGYRSSTQFHVFESTRQLPRFSMYALTSLDPASEPISYVNFTIAERAQRVVVWLGQNFLLPEDTHIQNAPFQ
VCFTSLRNGGHLHIKIKLSGEVDEYHSVHQKLSADMADHSNLIRSLLVGAEDARLMRDMKTMKSRYMELYDLNRDLLNGYKIRCNNHTEL

--------------------------------------------------------------
>52891_52891_7_MEIS2-BBS2_MEIS2_chr15_37242525_ENST00000397624_BBS2_chr16_56545196_ENST00000245157_length(transcript)=3261nt_BP=1064nt
CATCTTTATCCCTTCCTCTCTTTTCTGTTCGCCCTCTTCTCCCTGCTCTTTTTCCCTTTCCACCCCCCTCCTCTGTTCTCCCTCACCTCC
TGCGCCCCCTCCCCCTTCCCGGGTTCTGACAGTACGATGAGCTGCCCCATTACGGCGGGATGGACGGAGTAGGGGTTCCCGCTTCCATGT
ACGGAGACCCTCACGCGCCGCGGCCGATCCCCCCGGTTCACCACCTGAACCACGGGCCGCCGCTCCACGCCACACAGCACTACGGCGCGC
ACGCCCCGCACCCCAATGTCATGCCGGCCAGTATGGGATCCGCTGTCAACGACGCCTTGAAGCGGGACAAGGACGCGATCTATGGCTCTG
GTCTTTGAGAAGTGCGAGCTGGCGACCTGCACTCCCCGGGAACCTGGAGTGGCTGGCGGAGACGTCTGCTCCTCCGACTCCTTCAACGAG
GACATCGCGGTCTTCGCCAAGCAGGTTCGCGCCGAAAAGCCACTTTTTTCCTCAAATCCAGAGCTGGACAATTTGATGATACAAGCAATA
CAAGTACTAAGGTTTCATCTTTTGGAGTTAGAAAAGGTCCACGAACTGTGCGATAACTTCTGCCACCGATACATTAGCTGTTTGAAGGGG
AAAATGCCCATCGACCTCGTCATTGATGAAAGAGACGGCAGCTCCAAGTCAGATCATGAAGAACTTTCAGGCTCCTCCACAAATCTCGCT
GACCATAACCCTTCTTCTTGGCGAGACCACGATGATGCAACCTCAACCCACTCAGCAGGCACCCCAGGGCCCTCCAGTGGGGGCCATGCT
TCCCAGAGCGGAGACAACAGCAGTGAGCAAGGGGATGGTTTAGACAACAGTGTAGCTTCACCTGGTACAGGTGACGATGATGATCCGGAT
AAGGACAAAAAACGCCAGAAGAAAAGAGGCATTTTCCCCAAAGTAGCAACAAATATCATGAGAGCATGGCTCTTCCAGCATCTCACACAT
CCGTACCCTTCCGAAGAGCAGAAGAAACAGTTAGCGCAAGACACAGGACTTACAATTCTCCAAGTAAACAACTGGTAGCAGATGGGGCAA
ATGCAATTGTGCTGGGGACATTGGGAGACATTTCTTCCCCTCTTGCGATTATTGGTGGCAATTGTGCTCTGCAAGGTTTCAATCATGAAG
GAAGTGATCTCTTTTGGACGGTTACTGGAGACAATGTTAATTCCTTGGCCTTGTGTGACTTTGATGGTGATGGAAAGAAAGAGCTTCTTG
TTGGATCTGAGGATTTTGATATCCGAGTTTTTAAGGAAGATGAGATTGTGGCAGAAATGACAGAAACAGAGATAGTCACCTCTCTTTGTC
CCATGTATGGCAGTCGATTTGGTTATGCCCTTTCCAATGGCACAGTTGGAGTTTATGACAAAACATCCCGATACTGGAGAATTAAATCGA
AAAATCATGCCATGAGCATTCATGCTTTTGACCTTAATTCTGATGGAGTGAATGAACTGATAACTGGTTGGTCCAATGGGAAGGTTGATG
CTCGAAGTGACCGAACTGGGGAGGTCATCTTTAAGGACAATTTTTCTTCTGCAATTGCCGGTGTGGTAGAGGGAGATTACCGGATGGATG
GCCACATACAGTTAATCTGCTGCTCAGTGGATGGGGAAATCCGGGGCTACCTGCCTGGCACGGCTGAGATGAGGGGCAACCTCATGGACA
CCAGTGCAGAGCAGGACCTGATCCGAGAGCTGAGTCAGAAGAAGCAGAATCTGTTGCTGGAACTCCGTAACTATGAGGAAAATGCCAAGG
CTGAATTGGCCAGTCCACTGAACGAGGCTGATGGGCATCGGGGCATAATCCCAGCCAATACCAGGCTCCACACCACGCTCTCAGTCAGCC
TGGGGAATGAGACCCAAACTGCTCATACAGAATTACGCATTTCCACTTCTAATGACACCATCATCCGAGCAGTATTGATTTTTGCAGAAG
GAATTTTTACAGGTGAAAGCCACGTGGTACATCCCAGCATTCACAACCTCTCCAGTTCCATCTGCATCCCTATTGTGCCTCCCAAAGATG
TCCCTGTGGATCTGCACTTGAAGGCATTCGTGGGTTACAGAAGCAGCACCCAGTTTCATGTATTTGAATCGACAAGACAGCTCCCTCGAT
TCTCCATGTATGCGCTGACCAGCCTGGACCCTGCCAGTGAGCCAATCAGTTATGTTAACTTTACCATTGCAGAACGGGCACAGAGGGTTG
TTGTATGGCTCGGTCAGAACTTTCTGTTACCAGAAGACACTCACATTCAGAATGCTCCATTTCAAGTGTGTTTCACATCTTTACGGAATG
GCGGCCACCTGCATATAAAAATAAAACTTAGTGGAGAGATCACTATAAATACTGATGATATTGATTTGGCTGGTGATATCATCCAGTCAA
TGGCATCATTTTTTGCTATTGAAGACCTTCAAGTAGAAGCGGATTTTCCTGTCTATTTTGAGGAATTACGAAAGGTGCTAGTTAAGGTGG
ATGAATATCATTCAGTGCATCAGAAGCTCAGTGCTGATATGGCTGATCATTCTAATTTGATCCGAAGTTTGCTGGTCGGAGCTGAGGATG
CTCGTCTGATGAGGGACATGAAAACAATGAAGAGTCGTTATATGGAACTCTATGACCTTAATAGAGACTTGCTAAATGGATATAAAATTC
GCTGTAACAATCACACAGAGCTGTTGGGAAACCTCAAAGCAGTAAATCAAGCAATTCAAAGAGCAGGTCGTCTGCGGGTTGGAAAACCAA
AGAACCAGGTGATCACTGCTTGTCGGGATGCAATTCGAAGCAATAACATCAACACACTGTTCAAAATCATGCGAGTGGGGACAGCTTCTT
CCTAGGTGAGGAAAATACAGGTCATGAAGTTCCTGGCAAAGATTTTCTGTTAAAAACCTATGCTGGTTTGCTTTGGATCACACCCTGGTG
AACCCCGGGTGCTAAGAATGAAAATAACCTTGGTGAGTTGTACAAATTAAAGACAAAGAACTACATGTGAAGATAGACTTGCTTTCTATT
TTTAAATCAGTAGTAGTACTGTTGCTGAATAATACTAGGTTTTTATGGAATAGGATGAATGCTTTTGAAGTATTAGGGCTTCAGAGTCCA
ATTTTGCTTATTTATGGTATATAAATACATATTTTTTTCTTGAAATTGCAATTGAGTTTGTACTTTTCAAATAGATTATCTACTTTTTCA

>52891_52891_7_MEIS2-BBS2_MEIS2_chr15_37242525_ENST00000397624_BBS2_chr16_56545196_ENST00000245157_length(amino acids)=639AA_BP=33
MALPASHTSVPFRRAEETVSARHRTYNSPSKQLVADGANAIVLGTLGDISSPLAIIGGNCALQGFNHEGSDLFWTVTGDNVNSLALCDFD
GDGKKELLVGSEDFDIRVFKEDEIVAEMTETEIVTSLCPMYGSRFGYALSNGTVGVYDKTSRYWRIKSKNHAMSIHAFDLNSDGVNELIT
GWSNGKVDARSDRTGEVIFKDNFSSAIAGVVEGDYRMDGHIQLICCSVDGEIRGYLPGTAEMRGNLMDTSAEQDLIRELSQKKQNLLLEL
RNYEENAKAELASPLNEADGHRGIIPANTRLHTTLSVSLGNETQTAHTELRISTSNDTIIRAVLIFAEGIFTGESHVVHPSIHNLSSSIC
IPIVPPKDVPVDLHLKAFVGYRSSTQFHVFESTRQLPRFSMYALTSLDPASEPISYVNFTIAERAQRVVVWLGQNFLLPEDTHIQNAPFQ
VCFTSLRNGGHLHIKIKLSGEITINTDDIDLAGDIIQSMASFFAIEDLQVEADFPVYFEELRKVLVKVDEYHSVHQKLSADMADHSNLIR
SLLVGAEDARLMRDMKTMKSRYMELYDLNRDLLNGYKIRCNNHTELLGNLKAVNQAIQRAGRLRVGKPKNQVITACRDAIRSNNINTLFK

--------------------------------------------------------------
>52891_52891_8_MEIS2-BBS2_MEIS2_chr15_37242525_ENST00000397624_BBS2_chr16_56545196_ENST00000561951_length(transcript)=1909nt_BP=1064nt
CATCTTTATCCCTTCCTCTCTTTTCTGTTCGCCCTCTTCTCCCTGCTCTTTTTCCCTTTCCACCCCCCTCCTCTGTTCTCCCTCACCTCC
TGCGCCCCCTCCCCCTTCCCGGGTTCTGACAGTACGATGAGCTGCCCCATTACGGCGGGATGGACGGAGTAGGGGTTCCCGCTTCCATGT
ACGGAGACCCTCACGCGCCGCGGCCGATCCCCCCGGTTCACCACCTGAACCACGGGCCGCCGCTCCACGCCACACAGCACTACGGCGCGC
ACGCCCCGCACCCCAATGTCATGCCGGCCAGTATGGGATCCGCTGTCAACGACGCCTTGAAGCGGGACAAGGACGCGATCTATGGCTCTG
GTCTTTGAGAAGTGCGAGCTGGCGACCTGCACTCCCCGGGAACCTGGAGTGGCTGGCGGAGACGTCTGCTCCTCCGACTCCTTCAACGAG
GACATCGCGGTCTTCGCCAAGCAGGTTCGCGCCGAAAAGCCACTTTTTTCCTCAAATCCAGAGCTGGACAATTTGATGATACAAGCAATA
CAAGTACTAAGGTTTCATCTTTTGGAGTTAGAAAAGGTCCACGAACTGTGCGATAACTTCTGCCACCGATACATTAGCTGTTTGAAGGGG
AAAATGCCCATCGACCTCGTCATTGATGAAAGAGACGGCAGCTCCAAGTCAGATCATGAAGAACTTTCAGGCTCCTCCACAAATCTCGCT
GACCATAACCCTTCTTCTTGGCGAGACCACGATGATGCAACCTCAACCCACTCAGCAGGCACCCCAGGGCCCTCCAGTGGGGGCCATGCT
TCCCAGAGCGGAGACAACAGCAGTGAGCAAGGGGATGGTTTAGACAACAGTGTAGCTTCACCTGGTACAGGTGACGATGATGATCCGGAT
AAGGACAAAAAACGCCAGAAGAAAAGAGGCATTTTCCCCAAAGTAGCAACAAATATCATGAGAGCATGGCTCTTCCAGCATCTCACACAT
CCGTACCCTTCCGAAGAGCAGAAGAAACAGTTAGCGCAAGACACAGGACTTACAATTCTCCAAGTAAACAACTGGATGGGGCAAATGCAA
TTGTGCTGGGGACATTGGGAGACATTTCTTCCCCTCTTGCGATTATTGGTGGCAATTGTGCTCTGCAAGGTTTCAATCATGAAGGAAGTG
ATCTCTTTTGGACGGTTACTGGAGACAATGTTAATTCCTTGGCCTTGTGTGACTTTGATGGTGATGGAAAGAAAGAGCTTCTTGTTGGAT
CTGAGGATTTTGATATCCGAGTTTTTAAGGAAGATGAGATTGTGGCAGAAATGACAGAAACAGAGATAGTCACCTCTCTTTGTCCCATGT
ATGGCAGTCGATTTGGTTATGCCCTTTCCAATGGCACAGTTGGAGTTTATGACAAAACATCCCGATACTGGAGAATTAAATCGAAAAATC
ATGCCATGAGCATTCATGCTTTTGACCTTAATTCTGATGGAGTGAATGAACTGATAACTGGTTGGTCCAATGGGAAGGTTGATGCTCGAA
GTGACCGAACTGGGGAGGTCATCTTTAAGGACAATTTTTCTTCTGCAATTGCCGGTGTGGTAGAGGGAGATTACCGGATGGATGGCCACA
TACAGTTAATCTGCTGCTCAGTGGATGGGGAAATCCGGGGCTACCTGCCTGGCACGGCTGAGATGAGGGGCAACCTCATGGACACCAGTG
CAGAGCAGGACCTGATCCGAGAGCTGAGTCAGAAGAAGCAGAATCTGTTGCTGGAACTCCGTAACTATGAGGAAAATGCCAAGAACAATA
CTTCAAAAATGTTAAAGTCATGATGGGATACAGTGGACCATACCCATAGAAAGATGCAAGGGTATTTTCCCACAGGGCCAGATAGAGCAA

>52891_52891_8_MEIS2-BBS2_MEIS2_chr15_37242525_ENST00000397624_BBS2_chr16_56545196_ENST00000561951_length(amino acids)=320AA_BP=238
MALVFEKCELATCTPREPGVAGGDVCSSDSFNEDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISC
LKGKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGHASQSGDNSSEQGDGLDNSVASPGTGDDD
DPDKDKKRQKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWMGQMQLCWGHWETFLPLLRLLVAIVLCKVSIM

--------------------------------------------------------------
>52891_52891_9_MEIS2-BBS2_MEIS2_chr15_37242525_ENST00000397624_BBS2_chr16_56545196_ENST00000568104_length(transcript)=3163nt_BP=1064nt
CATCTTTATCCCTTCCTCTCTTTTCTGTTCGCCCTCTTCTCCCTGCTCTTTTTCCCTTTCCACCCCCCTCCTCTGTTCTCCCTCACCTCC
TGCGCCCCCTCCCCCTTCCCGGGTTCTGACAGTACGATGAGCTGCCCCATTACGGCGGGATGGACGGAGTAGGGGTTCCCGCTTCCATGT
ACGGAGACCCTCACGCGCCGCGGCCGATCCCCCCGGTTCACCACCTGAACCACGGGCCGCCGCTCCACGCCACACAGCACTACGGCGCGC
ACGCCCCGCACCCCAATGTCATGCCGGCCAGTATGGGATCCGCTGTCAACGACGCCTTGAAGCGGGACAAGGACGCGATCTATGGCTCTG
GTCTTTGAGAAGTGCGAGCTGGCGACCTGCACTCCCCGGGAACCTGGAGTGGCTGGCGGAGACGTCTGCTCCTCCGACTCCTTCAACGAG
GACATCGCGGTCTTCGCCAAGCAGGTTCGCGCCGAAAAGCCACTTTTTTCCTCAAATCCAGAGCTGGACAATTTGATGATACAAGCAATA
CAAGTACTAAGGTTTCATCTTTTGGAGTTAGAAAAGGTCCACGAACTGTGCGATAACTTCTGCCACCGATACATTAGCTGTTTGAAGGGG
AAAATGCCCATCGACCTCGTCATTGATGAAAGAGACGGCAGCTCCAAGTCAGATCATGAAGAACTTTCAGGCTCCTCCACAAATCTCGCT
GACCATAACCCTTCTTCTTGGCGAGACCACGATGATGCAACCTCAACCCACTCAGCAGGCACCCCAGGGCCCTCCAGTGGGGGCCATGCT
TCCCAGAGCGGAGACAACAGCAGTGAGCAAGGGGATGGTTTAGACAACAGTGTAGCTTCACCTGGTACAGGTGACGATGATGATCCGGAT
AAGGACAAAAAACGCCAGAAGAAAAGAGGCATTTTCCCCAAAGTAGCAACAAATATCATGAGAGCATGGCTCTTCCAGCATCTCACACAT
CCGTACCCTTCCGAAGAGCAGAAGAAACAGTTAGCGCAAGACACAGGACTTACAATTCTCCAAGTAAACAACTGGTAGCAGATGGGGCAA
ATGCAATTGTGCTGGGGACATTGGGAGACATTTCTTCCCCTCTTGCGATTATTGGTGGCAATTGTGCTCTGCAAGGTTTCAATCATGAAG
GAAGTGATCTCTTTTGGACGGTTACTGGAGACAATGTTAATTCCTTGGCCTTGTGTGACTTTGATGGTGATGGAAAGAAAGAGCTTCTTG
TTGGATCTGAGGATTTTGATATCCGAGTTTTTAAGGAAGATGAGATTGTGGCAGAAATGACAGAAACAGAGATAGTCACCTCTCTTTGTC
CCATGTATGGCAGTCGATTTGGTTATGCCCTTTCCAATGGCACAGTTGGAGTTTATGACAAAACATCCCGATACTGGAGAATTAAATCGA
AAAATCATGCCATGAGCATTCATGCTTTTGACCTTAATTCTGATGGAGTGAATGAACTGATAACTGGTTGGTCCAATGGGAAGGTTGATG
CTCGAAGTGACCGAACTGGGGAGGTCATCTTTAAGGACAATTTTTCTTCTGCAATTGCCGGTGTGGTAGAGGGAGATTACCGGATGGATG
GCCACATACAGTTAATCTGCTGCTCAGTGGATGGGGAAATCCGGGGCTACCTGCCTGGCACGGCTGAGATGAGGGGCAACCTCATGGACA
CCAGTGCAGAGCAGGACCTGATCCGAGAGCTGAGTCAGAAGAAGCAGAATCTGTTGCTGGAACTCCGTAACTATGAGGAAAATGCCAAGG
CTGAATTGGCCAGTCCACTGAACGAGGCTGATGGGCATCGGGGCATAATCCCAGCCAATACCAGGCTCCACACCACGCTCTCAGTCAGCC
TGGGGAATGAGACCCAAACTGCTCATACAGAATTACGCATTTCCACTTCTAATGACACCATCATCCGAGCAGTATTGATTTTTGCAGAAG
GAATTTTTACAGGTGAAAGCCACGTGGTACATCCCAGCATTCACAACCTCTCCAGTTCCATCTGCATCCCTATTGTGCCTCCCAAAGATG
TCCCTGTGGATCTGCACTTGAAGGCATTCGTGGGTTACAGAAGCAGCACCCAGTTTCATGTATTTGAATCGACAAGACAGCTCCCTCGAT
TCTCCATGTATGCGCTGACCAGCCTGGACCCTGCCAGTGAGCCAATCAGTTATGTTAACTTTACCATTGCAGAACGGGCACAGAGGGTTG
TTGTATGGCTCGGTCAGAACTTTCTGTTACCAGAAGACACTCACATTCAGAATGCTCCATTTCAAGTGTGTTTCACATCTTTACGGAATG
GCGGCCACCTGCATATAAAAATAAAACTTAGTGGAGAGGTGGATGAATATCATTCAGTGCATCAGAAGCTCAGTGCTGATATGGCTGATC
ATTCTAATTTGATCCGAAGTTTGCTGGTCGGAGCTGAGGATGCTCGTCTGATGAGGGACATGAAAACAATGAAGAGTCGTTATATGGAAC
TCTATGACCTTAATAGAGACTTGCTAAATGGATATAAAATTCGCTGTAACAATCACACAGAGCTGTTGGGAAACCTCAAAGCAGTAAATC
AAGCAATTCAAAGAGCAGGTCGTCTGCGGGTTGGAAAACCAAAGAACCAGGTGATCACTGCTTGTCGGGATGCAATTCGAAGCAATAACA
TCAACACACTGTTCAAAATCATGCGAGTGGGGACAGCTTCTTCCTAGGTGAGGAAAATACAGGTCATGAAGTTCCTGGCAAAGATTTTCT
GTTAAAAACCTATGCTGGTTTGCTTTGGATCACACCCTGGTGAACCCCGGGTGCTAAGAATGAAAATAACCTTGGTGAGTTGTACAAATT
AAAGACAAAGAACTACATGTGAAGATAGACTTGCTTTCTATTTTTAAATCAGTAGTAGTACTGTTGCTGAATAATACTAGGTTTTTATGG
AATAGGATGAATGCTTTTGAAGTATTAGGGCTTCAGAGTCCAATTTTGCTTATTTATGGTATATAAATACATATTTTTTTCTTGAAATTG
CAATTGAGTTTGTACTTTTCAAATAGATTATCTACTTTTTCATTAAAATGTAAAGATGTTAAACTTTGTGTTGATTGATTATAAAATCAC

>52891_52891_9_MEIS2-BBS2_MEIS2_chr15_37242525_ENST00000397624_BBS2_chr16_56545196_ENST00000568104_length(amino acids)=593AA_BP=33
MALPASHTSVPFRRAEETVSARHRTYNSPSKQLVADGANAIVLGTLGDISSPLAIIGGNCALQGFNHEGSDLFWTVTGDNVNSLALCDFD
GDGKKELLVGSEDFDIRVFKEDEIVAEMTETEIVTSLCPMYGSRFGYALSNGTVGVYDKTSRYWRIKSKNHAMSIHAFDLNSDGVNELIT
GWSNGKVDARSDRTGEVIFKDNFSSAIAGVVEGDYRMDGHIQLICCSVDGEIRGYLPGTAEMRGNLMDTSAEQDLIRELSQKKQNLLLEL
RNYEENAKAELASPLNEADGHRGIIPANTRLHTTLSVSLGNETQTAHTELRISTSNDTIIRAVLIFAEGIFTGESHVVHPSIHNLSSSIC
IPIVPPKDVPVDLHLKAFVGYRSSTQFHVFESTRQLPRFSMYALTSLDPASEPISYVNFTIAERAQRVVVWLGQNFLLPEDTHIQNAPFQ
VCFTSLRNGGHLHIKIKLSGEVDEYHSVHQKLSADMADHSNLIRSLLVGAEDARLMRDMKTMKSRYMELYDLNRDLLNGYKIRCNNHTEL

--------------------------------------------------------------
>52891_52891_10_MEIS2-BBS2_MEIS2_chr15_37242525_ENST00000424352_BBS2_chr16_56545196_ENST00000245157_length(transcript)=4238nt_BP=2041nt
GGCTCGGCGCGGCGCGCTCCTCCTCGCTCCCGCTCCCCACTCCCGGGATGTGTCTCCGCCGTACGACGGGCTATGGCCACCACGACTTCC
GGGTTCCGTCATTTCGTTCTCCCGCCGCCGACCCGCGCCGCCAAACTGAGGCTCTTCAATAAGCCAGGCAGCAGCCAACCTGCCAACACC
TACTGACACTCACTCATCTCCCAGAGAGAGAAAGAGAGCGAGAGAGAGCGAGCGCGAGAGAGCGAGCGCGAGTGAGAGCGAGCGAGCGAG
CGAGAAAGAGAGAGAGGGAGAGACAAAATACCTACCAGGAAAGGGGGGGAGGAAGTCCAATTTTTGCAAACTATTCATTTTTTTTTCTTG
ATTTTTCTCACTGCTTTCTTTGAACAATACTTTAAAGAGAGAGGATCGTATTATAGATACCGCGGGGGCAAAGCTAAAAAAGGGGGGAGG
GGGGAGGAAAAAATTCAAGAAGCAGAAACCCCTCGCGGAGTTTTACTGGAAGAAAAAAACGGGTCTGAAAGATTCCTCCTCTTCATCATC
ATCAACCATCATTCATTCACTACCTTGACATTCCGGGCTTTGATTGACAGCTGGAGTGGCAAAAAGCCATGAAACACGACAGTTCGGTTA
CATGTGGGCTGCTGACGGGCCGCTCGTAACCTTCAGTTCGGGGGCTTGACAATTTTTTTCTTCTTTTTCTTCTTTTTCTTTTCTTTCTTT
TTTTTTCCAACTGAGGGGAAGAGAAGAGAAAGAGGGGGAAAGGAGGACCGAAGAGGAGGAGGAGGGGAGGGGGGAGGAGGAGGAGGTGGA
GGAGGAGGAGGAAGATCAGGAGGAGGAGGAAGAAGAGGAAAAAAGAGAAAAAGAAGAAATATCACAGAAAAAAAAATTCTTCGTTGTCTA
GACTGGGCTTTTTTTCCCCCCTAAAAAATAGCATATTGGAGAATTGGGAGAAGTCTCTTTGGTTTGGAAAAAAAAAAAAGGAATCTTCAG
CCTAGATCACTTTCTTATCCGGACTGGGATATTAAATATACGACACATCCAGGAGTTTATTGGAGCGCAGACTGATGGCGCAAAGGTACG
ATGAGCTGCCCCATTACGGCGGGATGGACGGAGTAGGGGTTCCCGCTTCCATGTACGGAGACCCTCACGCGCCGCGGCCGATCCCCCCGG
TTCACCACCTGAACCACGGGCCGCCGCTCCACGCCACACAGCACTACGGCGCGCACGCCCCGCACCCCAATGTCATGCCGGCCAGTATGG
GATCCGCTGTCAACGACGCCTTGAAGCGGGACAAGGACGCGATCTATGGGCACCCGTTGTTTCCTCTGTTAGCTCTGGTCTTTGAGAAGT
GCGAGCTGGCGACCTGCACTCCCCGGGAACCTGGAGTGGCTGGCGGAGACGTCTGCTCCTCCGACTCCTTCAACGAGGACATCGCGGTCT
TCGCCAAGCAGGTTCGCGCCGAAAAGCCACTTTTTTCCTCAAATCCAGAGCTGGACAATTTGATGATACAAGCAATACAAGTACTAAGGT
TTCATCTTTTGGAGTTAGAAAAGGTCCACGAACTGTGCGATAACTTCTGCCACCGATACATTAGCTGTTTGAAGGGGAAAATGCCCATCG
ACCTCGTCATTGATGAAAGAGACGGCAGCTCCAAGTCAGATCATGAAGAACTTTCAGGCTCCTCCACAAATCTCGCTGACCATAACCCTT
CTTCTTGGCGAGACCACGATGATGCAACCTCAACCCACTCAGCAGGCACCCCAGGGCCCTCCAGTGGGGGCCATGCTTCCCAGAGCGGAG
ACAACAGCAGTGAGCAAGGGGATGGTTTAGACAACAGTGTAGCTTCACCTGGTACAGGTGACGATGATGATCCGGATAAGGACAAAAAAC
GCCAGAAGAAAAGAGGCATTTTCCCCAAAGTAGCAACAAATATCATGAGAGCATGGCTCTTCCAGCATCTCACACATCCGTACCCTTCCG
AAGAGCAGAAGAAACAGTTAGCGCAAGACACAGGACTTACAATTCTCCAAGTAAACAACTGGTAGCAGATGGGGCAAATGCAATTGTGCT
GGGGACATTGGGAGACATTTCTTCCCCTCTTGCGATTATTGGTGGCAATTGTGCTCTGCAAGGTTTCAATCATGAAGGAAGTGATCTCTT
TTGGACGGTTACTGGAGACAATGTTAATTCCTTGGCCTTGTGTGACTTTGATGGTGATGGAAAGAAAGAGCTTCTTGTTGGATCTGAGGA
TTTTGATATCCGAGTTTTTAAGGAAGATGAGATTGTGGCAGAAATGACAGAAACAGAGATAGTCACCTCTCTTTGTCCCATGTATGGCAG
TCGATTTGGTTATGCCCTTTCCAATGGCACAGTTGGAGTTTATGACAAAACATCCCGATACTGGAGAATTAAATCGAAAAATCATGCCAT
GAGCATTCATGCTTTTGACCTTAATTCTGATGGAGTGAATGAACTGATAACTGGTTGGTCCAATGGGAAGGTTGATGCTCGAAGTGACCG
AACTGGGGAGGTCATCTTTAAGGACAATTTTTCTTCTGCAATTGCCGGTGTGGTAGAGGGAGATTACCGGATGGATGGCCACATACAGTT
AATCTGCTGCTCAGTGGATGGGGAAATCCGGGGCTACCTGCCTGGCACGGCTGAGATGAGGGGCAACCTCATGGACACCAGTGCAGAGCA
GGACCTGATCCGAGAGCTGAGTCAGAAGAAGCAGAATCTGTTGCTGGAACTCCGTAACTATGAGGAAAATGCCAAGGCTGAATTGGCCAG
TCCACTGAACGAGGCTGATGGGCATCGGGGCATAATCCCAGCCAATACCAGGCTCCACACCACGCTCTCAGTCAGCCTGGGGAATGAGAC
CCAAACTGCTCATACAGAATTACGCATTTCCACTTCTAATGACACCATCATCCGAGCAGTATTGATTTTTGCAGAAGGAATTTTTACAGG
TGAAAGCCACGTGGTACATCCCAGCATTCACAACCTCTCCAGTTCCATCTGCATCCCTATTGTGCCTCCCAAAGATGTCCCTGTGGATCT
GCACTTGAAGGCATTCGTGGGTTACAGAAGCAGCACCCAGTTTCATGTATTTGAATCGACAAGACAGCTCCCTCGATTCTCCATGTATGC
GCTGACCAGCCTGGACCCTGCCAGTGAGCCAATCAGTTATGTTAACTTTACCATTGCAGAACGGGCACAGAGGGTTGTTGTATGGCTCGG
TCAGAACTTTCTGTTACCAGAAGACACTCACATTCAGAATGCTCCATTTCAAGTGTGTTTCACATCTTTACGGAATGGCGGCCACCTGCA
TATAAAAATAAAACTTAGTGGAGAGATCACTATAAATACTGATGATATTGATTTGGCTGGTGATATCATCCAGTCAATGGCATCATTTTT
TGCTATTGAAGACCTTCAAGTAGAAGCGGATTTTCCTGTCTATTTTGAGGAATTACGAAAGGTGCTAGTTAAGGTGGATGAATATCATTC
AGTGCATCAGAAGCTCAGTGCTGATATGGCTGATCATTCTAATTTGATCCGAAGTTTGCTGGTCGGAGCTGAGGATGCTCGTCTGATGAG
GGACATGAAAACAATGAAGAGTCGTTATATGGAACTCTATGACCTTAATAGAGACTTGCTAAATGGATATAAAATTCGCTGTAACAATCA
CACAGAGCTGTTGGGAAACCTCAAAGCAGTAAATCAAGCAATTCAAAGAGCAGGTCGTCTGCGGGTTGGAAAACCAAAGAACCAGGTGAT
CACTGCTTGTCGGGATGCAATTCGAAGCAATAACATCAACACACTGTTCAAAATCATGCGAGTGGGGACAGCTTCTTCCTAGGTGAGGAA
AATACAGGTCATGAAGTTCCTGGCAAAGATTTTCTGTTAAAAACCTATGCTGGTTTGCTTTGGATCACACCCTGGTGAACCCCGGGTGCT
AAGAATGAAAATAACCTTGGTGAGTTGTACAAATTAAAGACAAAGAACTACATGTGAAGATAGACTTGCTTTCTATTTTTAAATCAGTAG
TAGTACTGTTGCTGAATAATACTAGGTTTTTATGGAATAGGATGAATGCTTTTGAAGTATTAGGGCTTCAGAGTCCAATTTTGCTTATTT
ATGGTATATAAATACATATTTTTTTCTTGAAATTGCAATTGAGTTTGTACTTTTCAAATAGATTATCTACTTTTTCATTAAAATGTAAAG

>52891_52891_10_MEIS2-BBS2_MEIS2_chr15_37242525_ENST00000424352_BBS2_chr16_56545196_ENST00000245157_length(amino acids)=639AA_BP=33
MALPASHTSVPFRRAEETVSARHRTYNSPSKQLVADGANAIVLGTLGDISSPLAIIGGNCALQGFNHEGSDLFWTVTGDNVNSLALCDFD
GDGKKELLVGSEDFDIRVFKEDEIVAEMTETEIVTSLCPMYGSRFGYALSNGTVGVYDKTSRYWRIKSKNHAMSIHAFDLNSDGVNELIT
GWSNGKVDARSDRTGEVIFKDNFSSAIAGVVEGDYRMDGHIQLICCSVDGEIRGYLPGTAEMRGNLMDTSAEQDLIRELSQKKQNLLLEL
RNYEENAKAELASPLNEADGHRGIIPANTRLHTTLSVSLGNETQTAHTELRISTSNDTIIRAVLIFAEGIFTGESHVVHPSIHNLSSSIC
IPIVPPKDVPVDLHLKAFVGYRSSTQFHVFESTRQLPRFSMYALTSLDPASEPISYVNFTIAERAQRVVVWLGQNFLLPEDTHIQNAPFQ
VCFTSLRNGGHLHIKIKLSGEITINTDDIDLAGDIIQSMASFFAIEDLQVEADFPVYFEELRKVLVKVDEYHSVHQKLSADMADHSNLIR
SLLVGAEDARLMRDMKTMKSRYMELYDLNRDLLNGYKIRCNNHTELLGNLKAVNQAIQRAGRLRVGKPKNQVITACRDAIRSNNINTLFK

--------------------------------------------------------------
>52891_52891_11_MEIS2-BBS2_MEIS2_chr15_37242525_ENST00000424352_BBS2_chr16_56545196_ENST00000561951_length(transcript)=2886nt_BP=2041nt
GGCTCGGCGCGGCGCGCTCCTCCTCGCTCCCGCTCCCCACTCCCGGGATGTGTCTCCGCCGTACGACGGGCTATGGCCACCACGACTTCC
GGGTTCCGTCATTTCGTTCTCCCGCCGCCGACCCGCGCCGCCAAACTGAGGCTCTTCAATAAGCCAGGCAGCAGCCAACCTGCCAACACC
TACTGACACTCACTCATCTCCCAGAGAGAGAAAGAGAGCGAGAGAGAGCGAGCGCGAGAGAGCGAGCGCGAGTGAGAGCGAGCGAGCGAG
CGAGAAAGAGAGAGAGGGAGAGACAAAATACCTACCAGGAAAGGGGGGGAGGAAGTCCAATTTTTGCAAACTATTCATTTTTTTTTCTTG
ATTTTTCTCACTGCTTTCTTTGAACAATACTTTAAAGAGAGAGGATCGTATTATAGATACCGCGGGGGCAAAGCTAAAAAAGGGGGGAGG
GGGGAGGAAAAAATTCAAGAAGCAGAAACCCCTCGCGGAGTTTTACTGGAAGAAAAAAACGGGTCTGAAAGATTCCTCCTCTTCATCATC
ATCAACCATCATTCATTCACTACCTTGACATTCCGGGCTTTGATTGACAGCTGGAGTGGCAAAAAGCCATGAAACACGACAGTTCGGTTA
CATGTGGGCTGCTGACGGGCCGCTCGTAACCTTCAGTTCGGGGGCTTGACAATTTTTTTCTTCTTTTTCTTCTTTTTCTTTTCTTTCTTT
TTTTTTCCAACTGAGGGGAAGAGAAGAGAAAGAGGGGGAAAGGAGGACCGAAGAGGAGGAGGAGGGGAGGGGGGAGGAGGAGGAGGTGGA
GGAGGAGGAGGAAGATCAGGAGGAGGAGGAAGAAGAGGAAAAAAGAGAAAAAGAAGAAATATCACAGAAAAAAAAATTCTTCGTTGTCTA
GACTGGGCTTTTTTTCCCCCCTAAAAAATAGCATATTGGAGAATTGGGAGAAGTCTCTTTGGTTTGGAAAAAAAAAAAAGGAATCTTCAG
CCTAGATCACTTTCTTATCCGGACTGGGATATTAAATATACGACACATCCAGGAGTTTATTGGAGCGCAGACTGATGGCGCAAAGGTACG
ATGAGCTGCCCCATTACGGCGGGATGGACGGAGTAGGGGTTCCCGCTTCCATGTACGGAGACCCTCACGCGCCGCGGCCGATCCCCCCGG
TTCACCACCTGAACCACGGGCCGCCGCTCCACGCCACACAGCACTACGGCGCGCACGCCCCGCACCCCAATGTCATGCCGGCCAGTATGG
GATCCGCTGTCAACGACGCCTTGAAGCGGGACAAGGACGCGATCTATGGGCACCCGTTGTTTCCTCTGTTAGCTCTGGTCTTTGAGAAGT
GCGAGCTGGCGACCTGCACTCCCCGGGAACCTGGAGTGGCTGGCGGAGACGTCTGCTCCTCCGACTCCTTCAACGAGGACATCGCGGTCT
TCGCCAAGCAGGTTCGCGCCGAAAAGCCACTTTTTTCCTCAAATCCAGAGCTGGACAATTTGATGATACAAGCAATACAAGTACTAAGGT
TTCATCTTTTGGAGTTAGAAAAGGTCCACGAACTGTGCGATAACTTCTGCCACCGATACATTAGCTGTTTGAAGGGGAAAATGCCCATCG
ACCTCGTCATTGATGAAAGAGACGGCAGCTCCAAGTCAGATCATGAAGAACTTTCAGGCTCCTCCACAAATCTCGCTGACCATAACCCTT
CTTCTTGGCGAGACCACGATGATGCAACCTCAACCCACTCAGCAGGCACCCCAGGGCCCTCCAGTGGGGGCCATGCTTCCCAGAGCGGAG
ACAACAGCAGTGAGCAAGGGGATGGTTTAGACAACAGTGTAGCTTCACCTGGTACAGGTGACGATGATGATCCGGATAAGGACAAAAAAC
GCCAGAAGAAAAGAGGCATTTTCCCCAAAGTAGCAACAAATATCATGAGAGCATGGCTCTTCCAGCATCTCACACATCCGTACCCTTCCG
AAGAGCAGAAGAAACAGTTAGCGCAAGACACAGGACTTACAATTCTCCAAGTAAACAACTGGATGGGGCAAATGCAATTGTGCTGGGGAC
ATTGGGAGACATTTCTTCCCCTCTTGCGATTATTGGTGGCAATTGTGCTCTGCAAGGTTTCAATCATGAAGGAAGTGATCTCTTTTGGAC
GGTTACTGGAGACAATGTTAATTCCTTGGCCTTGTGTGACTTTGATGGTGATGGAAAGAAAGAGCTTCTTGTTGGATCTGAGGATTTTGA
TATCCGAGTTTTTAAGGAAGATGAGATTGTGGCAGAAATGACAGAAACAGAGATAGTCACCTCTCTTTGTCCCATGTATGGCAGTCGATT
TGGTTATGCCCTTTCCAATGGCACAGTTGGAGTTTATGACAAAACATCCCGATACTGGAGAATTAAATCGAAAAATCATGCCATGAGCAT
TCATGCTTTTGACCTTAATTCTGATGGAGTGAATGAACTGATAACTGGTTGGTCCAATGGGAAGGTTGATGCTCGAAGTGACCGAACTGG
GGAGGTCATCTTTAAGGACAATTTTTCTTCTGCAATTGCCGGTGTGGTAGAGGGAGATTACCGGATGGATGGCCACATACAGTTAATCTG
CTGCTCAGTGGATGGGGAAATCCGGGGCTACCTGCCTGGCACGGCTGAGATGAGGGGCAACCTCATGGACACCAGTGCAGAGCAGGACCT
GATCCGAGAGCTGAGTCAGAAGAAGCAGAATCTGTTGCTGGAACTCCGTAACTATGAGGAAAATGCCAAGAACAATACTTCAAAAATGTT
AAAGTCATGATGGGATACAGTGGACCATACCCATAGAAAGATGCAAGGGTATTTTCCCACAGGGCCAGATAGAGCAAGGGAGCACTAATG

>52891_52891_11_MEIS2-BBS2_MEIS2_chr15_37242525_ENST00000424352_BBS2_chr16_56545196_ENST00000561951_length(amino acids)=413AA_BP=331
MERRLMAQRYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNVMPASMGSAVNDALKRDKDAIYGHPL
FPLLALVFEKCELATCTPREPGVAGGDVCSSDSFNEDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRY
ISCLKGKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGHASQSGDNSSEQGDGLDNSVASPGTG
DDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWMGQMQLCWGHWETFLPLLRLLVAIVLCKV

--------------------------------------------------------------
>52891_52891_12_MEIS2-BBS2_MEIS2_chr15_37242525_ENST00000424352_BBS2_chr16_56545196_ENST00000568104_length(transcript)=4140nt_BP=2041nt
GGCTCGGCGCGGCGCGCTCCTCCTCGCTCCCGCTCCCCACTCCCGGGATGTGTCTCCGCCGTACGACGGGCTATGGCCACCACGACTTCC
GGGTTCCGTCATTTCGTTCTCCCGCCGCCGACCCGCGCCGCCAAACTGAGGCTCTTCAATAAGCCAGGCAGCAGCCAACCTGCCAACACC
TACTGACACTCACTCATCTCCCAGAGAGAGAAAGAGAGCGAGAGAGAGCGAGCGCGAGAGAGCGAGCGCGAGTGAGAGCGAGCGAGCGAG
CGAGAAAGAGAGAGAGGGAGAGACAAAATACCTACCAGGAAAGGGGGGGAGGAAGTCCAATTTTTGCAAACTATTCATTTTTTTTTCTTG
ATTTTTCTCACTGCTTTCTTTGAACAATACTTTAAAGAGAGAGGATCGTATTATAGATACCGCGGGGGCAAAGCTAAAAAAGGGGGGAGG
GGGGAGGAAAAAATTCAAGAAGCAGAAACCCCTCGCGGAGTTTTACTGGAAGAAAAAAACGGGTCTGAAAGATTCCTCCTCTTCATCATC
ATCAACCATCATTCATTCACTACCTTGACATTCCGGGCTTTGATTGACAGCTGGAGTGGCAAAAAGCCATGAAACACGACAGTTCGGTTA
CATGTGGGCTGCTGACGGGCCGCTCGTAACCTTCAGTTCGGGGGCTTGACAATTTTTTTCTTCTTTTTCTTCTTTTTCTTTTCTTTCTTT
TTTTTTCCAACTGAGGGGAAGAGAAGAGAAAGAGGGGGAAAGGAGGACCGAAGAGGAGGAGGAGGGGAGGGGGGAGGAGGAGGAGGTGGA
GGAGGAGGAGGAAGATCAGGAGGAGGAGGAAGAAGAGGAAAAAAGAGAAAAAGAAGAAATATCACAGAAAAAAAAATTCTTCGTTGTCTA
GACTGGGCTTTTTTTCCCCCCTAAAAAATAGCATATTGGAGAATTGGGAGAAGTCTCTTTGGTTTGGAAAAAAAAAAAAGGAATCTTCAG
CCTAGATCACTTTCTTATCCGGACTGGGATATTAAATATACGACACATCCAGGAGTTTATTGGAGCGCAGACTGATGGCGCAAAGGTACG
ATGAGCTGCCCCATTACGGCGGGATGGACGGAGTAGGGGTTCCCGCTTCCATGTACGGAGACCCTCACGCGCCGCGGCCGATCCCCCCGG
TTCACCACCTGAACCACGGGCCGCCGCTCCACGCCACACAGCACTACGGCGCGCACGCCCCGCACCCCAATGTCATGCCGGCCAGTATGG
GATCCGCTGTCAACGACGCCTTGAAGCGGGACAAGGACGCGATCTATGGGCACCCGTTGTTTCCTCTGTTAGCTCTGGTCTTTGAGAAGT
GCGAGCTGGCGACCTGCACTCCCCGGGAACCTGGAGTGGCTGGCGGAGACGTCTGCTCCTCCGACTCCTTCAACGAGGACATCGCGGTCT
TCGCCAAGCAGGTTCGCGCCGAAAAGCCACTTTTTTCCTCAAATCCAGAGCTGGACAATTTGATGATACAAGCAATACAAGTACTAAGGT
TTCATCTTTTGGAGTTAGAAAAGGTCCACGAACTGTGCGATAACTTCTGCCACCGATACATTAGCTGTTTGAAGGGGAAAATGCCCATCG
ACCTCGTCATTGATGAAAGAGACGGCAGCTCCAAGTCAGATCATGAAGAACTTTCAGGCTCCTCCACAAATCTCGCTGACCATAACCCTT
CTTCTTGGCGAGACCACGATGATGCAACCTCAACCCACTCAGCAGGCACCCCAGGGCCCTCCAGTGGGGGCCATGCTTCCCAGAGCGGAG
ACAACAGCAGTGAGCAAGGGGATGGTTTAGACAACAGTGTAGCTTCACCTGGTACAGGTGACGATGATGATCCGGATAAGGACAAAAAAC
GCCAGAAGAAAAGAGGCATTTTCCCCAAAGTAGCAACAAATATCATGAGAGCATGGCTCTTCCAGCATCTCACACATCCGTACCCTTCCG
AAGAGCAGAAGAAACAGTTAGCGCAAGACACAGGACTTACAATTCTCCAAGTAAACAACTGGTAGCAGATGGGGCAAATGCAATTGTGCT
GGGGACATTGGGAGACATTTCTTCCCCTCTTGCGATTATTGGTGGCAATTGTGCTCTGCAAGGTTTCAATCATGAAGGAAGTGATCTCTT
TTGGACGGTTACTGGAGACAATGTTAATTCCTTGGCCTTGTGTGACTTTGATGGTGATGGAAAGAAAGAGCTTCTTGTTGGATCTGAGGA
TTTTGATATCCGAGTTTTTAAGGAAGATGAGATTGTGGCAGAAATGACAGAAACAGAGATAGTCACCTCTCTTTGTCCCATGTATGGCAG
TCGATTTGGTTATGCCCTTTCCAATGGCACAGTTGGAGTTTATGACAAAACATCCCGATACTGGAGAATTAAATCGAAAAATCATGCCAT
GAGCATTCATGCTTTTGACCTTAATTCTGATGGAGTGAATGAACTGATAACTGGTTGGTCCAATGGGAAGGTTGATGCTCGAAGTGACCG
AACTGGGGAGGTCATCTTTAAGGACAATTTTTCTTCTGCAATTGCCGGTGTGGTAGAGGGAGATTACCGGATGGATGGCCACATACAGTT
AATCTGCTGCTCAGTGGATGGGGAAATCCGGGGCTACCTGCCTGGCACGGCTGAGATGAGGGGCAACCTCATGGACACCAGTGCAGAGCA
GGACCTGATCCGAGAGCTGAGTCAGAAGAAGCAGAATCTGTTGCTGGAACTCCGTAACTATGAGGAAAATGCCAAGGCTGAATTGGCCAG
TCCACTGAACGAGGCTGATGGGCATCGGGGCATAATCCCAGCCAATACCAGGCTCCACACCACGCTCTCAGTCAGCCTGGGGAATGAGAC
CCAAACTGCTCATACAGAATTACGCATTTCCACTTCTAATGACACCATCATCCGAGCAGTATTGATTTTTGCAGAAGGAATTTTTACAGG
TGAAAGCCACGTGGTACATCCCAGCATTCACAACCTCTCCAGTTCCATCTGCATCCCTATTGTGCCTCCCAAAGATGTCCCTGTGGATCT
GCACTTGAAGGCATTCGTGGGTTACAGAAGCAGCACCCAGTTTCATGTATTTGAATCGACAAGACAGCTCCCTCGATTCTCCATGTATGC
GCTGACCAGCCTGGACCCTGCCAGTGAGCCAATCAGTTATGTTAACTTTACCATTGCAGAACGGGCACAGAGGGTTGTTGTATGGCTCGG
TCAGAACTTTCTGTTACCAGAAGACACTCACATTCAGAATGCTCCATTTCAAGTGTGTTTCACATCTTTACGGAATGGCGGCCACCTGCA
TATAAAAATAAAACTTAGTGGAGAGGTGGATGAATATCATTCAGTGCATCAGAAGCTCAGTGCTGATATGGCTGATCATTCTAATTTGAT
CCGAAGTTTGCTGGTCGGAGCTGAGGATGCTCGTCTGATGAGGGACATGAAAACAATGAAGAGTCGTTATATGGAACTCTATGACCTTAA
TAGAGACTTGCTAAATGGATATAAAATTCGCTGTAACAATCACACAGAGCTGTTGGGAAACCTCAAAGCAGTAAATCAAGCAATTCAAAG
AGCAGGTCGTCTGCGGGTTGGAAAACCAAAGAACCAGGTGATCACTGCTTGTCGGGATGCAATTCGAAGCAATAACATCAACACACTGTT
CAAAATCATGCGAGTGGGGACAGCTTCTTCCTAGGTGAGGAAAATACAGGTCATGAAGTTCCTGGCAAAGATTTTCTGTTAAAAACCTAT
GCTGGTTTGCTTTGGATCACACCCTGGTGAACCCCGGGTGCTAAGAATGAAAATAACCTTGGTGAGTTGTACAAATTAAAGACAAAGAAC
TACATGTGAAGATAGACTTGCTTTCTATTTTTAAATCAGTAGTAGTACTGTTGCTGAATAATACTAGGTTTTTATGGAATAGGATGAATG
CTTTTGAAGTATTAGGGCTTCAGAGTCCAATTTTGCTTATTTATGGTATATAAATACATATTTTTTTCTTGAAATTGCAATTGAGTTTGT
ACTTTTCAAATAGATTATCTACTTTTTCATTAAAATGTAAAGATGTTAAACTTTGTGTTGATTGATTATAAAATCACCACCAAATCAGAA

>52891_52891_12_MEIS2-BBS2_MEIS2_chr15_37242525_ENST00000424352_BBS2_chr16_56545196_ENST00000568104_length(amino acids)=593AA_BP=33
MALPASHTSVPFRRAEETVSARHRTYNSPSKQLVADGANAIVLGTLGDISSPLAIIGGNCALQGFNHEGSDLFWTVTGDNVNSLALCDFD
GDGKKELLVGSEDFDIRVFKEDEIVAEMTETEIVTSLCPMYGSRFGYALSNGTVGVYDKTSRYWRIKSKNHAMSIHAFDLNSDGVNELIT
GWSNGKVDARSDRTGEVIFKDNFSSAIAGVVEGDYRMDGHIQLICCSVDGEIRGYLPGTAEMRGNLMDTSAEQDLIRELSQKKQNLLLEL
RNYEENAKAELASPLNEADGHRGIIPANTRLHTTLSVSLGNETQTAHTELRISTSNDTIIRAVLIFAEGIFTGESHVVHPSIHNLSSSIC
IPIVPPKDVPVDLHLKAFVGYRSSTQFHVFESTRQLPRFSMYALTSLDPASEPISYVNFTIAERAQRVVVWLGQNFLLPEDTHIQNAPFQ
VCFTSLRNGGHLHIKIKLSGEVDEYHSVHQKLSADMADHSNLIRSLLVGAEDARLMRDMKTMKSRYMELYDLNRDLLNGYKIRCNNHTEL

--------------------------------------------------------------
>52891_52891_13_MEIS2-BBS2_MEIS2_chr15_37242525_ENST00000444725_BBS2_chr16_56545196_ENST00000245157_length(transcript)=4211nt_BP=2014nt
TCCCGCTCCCCACTCCCGGGATGTGTCTCCGCCGTACGACGGGCTATGGCCACCACGACTTCCGGGTTCCGTCATTTCGTTCTCCCGCCG
CCGACCCGCGCCGCCAAACTGAGGCTCTTCAATAAGCCAGGCAGCAGCCAACCTGCCAACACCTACTGACACTCACTCATCTCCCAGAGA
GAGAAAGAGAGCGAGAGAGAGCGAGCGCGAGAGAGCGAGCGCGAGTGAGAGCGAGCGAGCGAGCGAGAAAGAGAGAGAGGGAGAGACAAA
ATACCTACCAGGAAAGGGGGGGAGGAAGTCCAATTTTTGCAAACTATTCATTTTTTTTTCTTGATTTTTCTCACTGCTTTCTTTGAACAA
TACTTTAAAGAGAGAGGATCGTATTATAGATACCGCGGGGGCAAAGCTAAAAAAGGGGGGAGGGGGGAGGAAAAAATTCAAGAAGCAGAA
ACCCCTCGCGGAGTTTTACTGGAAGAAAAAAACGGGTCTGAAAGATTCCTCCTCTTCATCATCATCAACCATCATTCATTCACTACCTTG
ACATTCCGGGCTTTGATTGACAGCTGGAGTGGCAAAAAGCCATGAAACACGACAGTTCGGTTACATGTGGGCTGCTGACGGGCCGCTCGT
AACCTTCAGTTCGGGGGCTTGACAATTTTTTTCTTCTTTTTCTTCTTTTTCTTTTCTTTCTTTTTTTTTCCAACTGAGGGGAAGAGAAGA
GAAAGAGGGGGAAAGGAGGACCGAAGAGGAGGAGGAGGGGAGGGGGGAGGAGGAGGAGGTGGAGGAGGAGGAGGAAGATCAGGAGGAGGA
GGAAGAAGAGGAAAAAAGAGAAAAAGAAGAAATATCACAGAAAAAAAAATTCTTCGTTGTCTAGACTGGGCTTTTTTTCCCCCCTAAAAA
ATAGCATATTGGAGAATTGGGAGAAGTCTCTTTGGTTTGGAAAAAAAAAAAAGGAATCTTCAGCCTAGATCACTTTCTTATCCGGACTGG
GATATTAAATATACGACACATCCAGGAGTTTATTGGAGCGCAGACTGATGGCGCAAAGGTACGATGAGCTGCCCCATTACGGCGGGATGG
ACGGAGTAGGGGTTCCCGCTTCCATGTACGGAGACCCTCACGCGCCGCGGCCGATCCCCCCGGTTCACCACCTGAACCACGGGCCGCCGC
TCCACGCCACACAGCACTACGGCGCGCACGCCCCGCACCCCAATGTCATGCCGGCCAGTATGGGATCCGCTGTCAACGACGCCTTGAAGC
GGGACAAGGACGCGATCTATGGGCACCCGTTGTTTCCTCTGTTAGCTCTGGTCTTTGAGAAGTGCGAGCTGGCGACCTGCACTCCCCGGG
AACCTGGAGTGGCTGGCGGAGACGTCTGCTCCTCCGACTCCTTCAACGAGGACATCGCGGTCTTCGCCAAGCAGGTTCGCGCCGAAAAGC
CACTTTTTTCCTCAAATCCAGAGCTGGACAATTTGATGATACAAGCAATACAAGTACTAAGGTTTCATCTTTTGGAGTTAGAAAAGGTCC
ACGAACTGTGCGATAACTTCTGCCACCGATACATTAGCTGTTTGAAGGGGAAAATGCCCATCGACCTCGTCATTGATGAAAGAGACGGCA
GCTCCAAGTCAGATCATGAAGAACTTTCAGGCTCCTCCACAAATCTCGCTGACCATAACCCTTCTTCTTGGCGAGACCACGATGATGCAA
CCTCAACCCACTCAGCAGGCACCCCAGGGCCCTCCAGTGGGGGCCATGCTTCCCAGAGCGGAGACAACAGCAGTGAGCAAGGGGATGGTT
TAGACAACAGTGTAGCTTCACCTGGTACAGGTGACGATGATGATCCGGATAAGGACAAAAAACGCCAGAAGAAAAGAGGCATTTTCCCCA
AAGTAGCAACAAATATCATGAGAGCATGGCTCTTCCAGCATCTCACACATCCGTACCCTTCCGAAGAGCAGAAGAAACAGTTAGCGCAAG
ACACAGGACTTACAATTCTCCAAGTAAACAACTGGTAGCAGATGGGGCAAATGCAATTGTGCTGGGGACATTGGGAGACATTTCTTCCCC
TCTTGCGATTATTGGTGGCAATTGTGCTCTGCAAGGTTTCAATCATGAAGGAAGTGATCTCTTTTGGACGGTTACTGGAGACAATGTTAA
TTCCTTGGCCTTGTGTGACTTTGATGGTGATGGAAAGAAAGAGCTTCTTGTTGGATCTGAGGATTTTGATATCCGAGTTTTTAAGGAAGA
TGAGATTGTGGCAGAAATGACAGAAACAGAGATAGTCACCTCTCTTTGTCCCATGTATGGCAGTCGATTTGGTTATGCCCTTTCCAATGG
CACAGTTGGAGTTTATGACAAAACATCCCGATACTGGAGAATTAAATCGAAAAATCATGCCATGAGCATTCATGCTTTTGACCTTAATTC
TGATGGAGTGAATGAACTGATAACTGGTTGGTCCAATGGGAAGGTTGATGCTCGAAGTGACCGAACTGGGGAGGTCATCTTTAAGGACAA
TTTTTCTTCTGCAATTGCCGGTGTGGTAGAGGGAGATTACCGGATGGATGGCCACATACAGTTAATCTGCTGCTCAGTGGATGGGGAAAT
CCGGGGCTACCTGCCTGGCACGGCTGAGATGAGGGGCAACCTCATGGACACCAGTGCAGAGCAGGACCTGATCCGAGAGCTGAGTCAGAA
GAAGCAGAATCTGTTGCTGGAACTCCGTAACTATGAGGAAAATGCCAAGGCTGAATTGGCCAGTCCACTGAACGAGGCTGATGGGCATCG
GGGCATAATCCCAGCCAATACCAGGCTCCACACCACGCTCTCAGTCAGCCTGGGGAATGAGACCCAAACTGCTCATACAGAATTACGCAT
TTCCACTTCTAATGACACCATCATCCGAGCAGTATTGATTTTTGCAGAAGGAATTTTTACAGGTGAAAGCCACGTGGTACATCCCAGCAT
TCACAACCTCTCCAGTTCCATCTGCATCCCTATTGTGCCTCCCAAAGATGTCCCTGTGGATCTGCACTTGAAGGCATTCGTGGGTTACAG
AAGCAGCACCCAGTTTCATGTATTTGAATCGACAAGACAGCTCCCTCGATTCTCCATGTATGCGCTGACCAGCCTGGACCCTGCCAGTGA
GCCAATCAGTTATGTTAACTTTACCATTGCAGAACGGGCACAGAGGGTTGTTGTATGGCTCGGTCAGAACTTTCTGTTACCAGAAGACAC
TCACATTCAGAATGCTCCATTTCAAGTGTGTTTCACATCTTTACGGAATGGCGGCCACCTGCATATAAAAATAAAACTTAGTGGAGAGAT
CACTATAAATACTGATGATATTGATTTGGCTGGTGATATCATCCAGTCAATGGCATCATTTTTTGCTATTGAAGACCTTCAAGTAGAAGC
GGATTTTCCTGTCTATTTTGAGGAATTACGAAAGGTGCTAGTTAAGGTGGATGAATATCATTCAGTGCATCAGAAGCTCAGTGCTGATAT
GGCTGATCATTCTAATTTGATCCGAAGTTTGCTGGTCGGAGCTGAGGATGCTCGTCTGATGAGGGACATGAAAACAATGAAGAGTCGTTA
TATGGAACTCTATGACCTTAATAGAGACTTGCTAAATGGATATAAAATTCGCTGTAACAATCACACAGAGCTGTTGGGAAACCTCAAAGC
AGTAAATCAAGCAATTCAAAGAGCAGGTCGTCTGCGGGTTGGAAAACCAAAGAACCAGGTGATCACTGCTTGTCGGGATGCAATTCGAAG
CAATAACATCAACACACTGTTCAAAATCATGCGAGTGGGGACAGCTTCTTCCTAGGTGAGGAAAATACAGGTCATGAAGTTCCTGGCAAA
GATTTTCTGTTAAAAACCTATGCTGGTTTGCTTTGGATCACACCCTGGTGAACCCCGGGTGCTAAGAATGAAAATAACCTTGGTGAGTTG
TACAAATTAAAGACAAAGAACTACATGTGAAGATAGACTTGCTTTCTATTTTTAAATCAGTAGTAGTACTGTTGCTGAATAATACTAGGT
TTTTATGGAATAGGATGAATGCTTTTGAAGTATTAGGGCTTCAGAGTCCAATTTTGCTTATTTATGGTATATAAATACATATTTTTTTCT

>52891_52891_13_MEIS2-BBS2_MEIS2_chr15_37242525_ENST00000444725_BBS2_chr16_56545196_ENST00000245157_length(amino acids)=639AA_BP=33
MALPASHTSVPFRRAEETVSARHRTYNSPSKQLVADGANAIVLGTLGDISSPLAIIGGNCALQGFNHEGSDLFWTVTGDNVNSLALCDFD
GDGKKELLVGSEDFDIRVFKEDEIVAEMTETEIVTSLCPMYGSRFGYALSNGTVGVYDKTSRYWRIKSKNHAMSIHAFDLNSDGVNELIT
GWSNGKVDARSDRTGEVIFKDNFSSAIAGVVEGDYRMDGHIQLICCSVDGEIRGYLPGTAEMRGNLMDTSAEQDLIRELSQKKQNLLLEL
RNYEENAKAELASPLNEADGHRGIIPANTRLHTTLSVSLGNETQTAHTELRISTSNDTIIRAVLIFAEGIFTGESHVVHPSIHNLSSSIC
IPIVPPKDVPVDLHLKAFVGYRSSTQFHVFESTRQLPRFSMYALTSLDPASEPISYVNFTIAERAQRVVVWLGQNFLLPEDTHIQNAPFQ
VCFTSLRNGGHLHIKIKLSGEITINTDDIDLAGDIIQSMASFFAIEDLQVEADFPVYFEELRKVLVKVDEYHSVHQKLSADMADHSNLIR
SLLVGAEDARLMRDMKTMKSRYMELYDLNRDLLNGYKIRCNNHTELLGNLKAVNQAIQRAGRLRVGKPKNQVITACRDAIRSNNINTLFK

--------------------------------------------------------------
>52891_52891_14_MEIS2-BBS2_MEIS2_chr15_37242525_ENST00000444725_BBS2_chr16_56545196_ENST00000561951_length(transcript)=2859nt_BP=2014nt
TCCCGCTCCCCACTCCCGGGATGTGTCTCCGCCGTACGACGGGCTATGGCCACCACGACTTCCGGGTTCCGTCATTTCGTTCTCCCGCCG
CCGACCCGCGCCGCCAAACTGAGGCTCTTCAATAAGCCAGGCAGCAGCCAACCTGCCAACACCTACTGACACTCACTCATCTCCCAGAGA
GAGAAAGAGAGCGAGAGAGAGCGAGCGCGAGAGAGCGAGCGCGAGTGAGAGCGAGCGAGCGAGCGAGAAAGAGAGAGAGGGAGAGACAAA
ATACCTACCAGGAAAGGGGGGGAGGAAGTCCAATTTTTGCAAACTATTCATTTTTTTTTCTTGATTTTTCTCACTGCTTTCTTTGAACAA
TACTTTAAAGAGAGAGGATCGTATTATAGATACCGCGGGGGCAAAGCTAAAAAAGGGGGGAGGGGGGAGGAAAAAATTCAAGAAGCAGAA
ACCCCTCGCGGAGTTTTACTGGAAGAAAAAAACGGGTCTGAAAGATTCCTCCTCTTCATCATCATCAACCATCATTCATTCACTACCTTG
ACATTCCGGGCTTTGATTGACAGCTGGAGTGGCAAAAAGCCATGAAACACGACAGTTCGGTTACATGTGGGCTGCTGACGGGCCGCTCGT
AACCTTCAGTTCGGGGGCTTGACAATTTTTTTCTTCTTTTTCTTCTTTTTCTTTTCTTTCTTTTTTTTTCCAACTGAGGGGAAGAGAAGA
GAAAGAGGGGGAAAGGAGGACCGAAGAGGAGGAGGAGGGGAGGGGGGAGGAGGAGGAGGTGGAGGAGGAGGAGGAAGATCAGGAGGAGGA
GGAAGAAGAGGAAAAAAGAGAAAAAGAAGAAATATCACAGAAAAAAAAATTCTTCGTTGTCTAGACTGGGCTTTTTTTCCCCCCTAAAAA
ATAGCATATTGGAGAATTGGGAGAAGTCTCTTTGGTTTGGAAAAAAAAAAAAGGAATCTTCAGCCTAGATCACTTTCTTATCCGGACTGG
GATATTAAATATACGACACATCCAGGAGTTTATTGGAGCGCAGACTGATGGCGCAAAGGTACGATGAGCTGCCCCATTACGGCGGGATGG
ACGGAGTAGGGGTTCCCGCTTCCATGTACGGAGACCCTCACGCGCCGCGGCCGATCCCCCCGGTTCACCACCTGAACCACGGGCCGCCGC
TCCACGCCACACAGCACTACGGCGCGCACGCCCCGCACCCCAATGTCATGCCGGCCAGTATGGGATCCGCTGTCAACGACGCCTTGAAGC
GGGACAAGGACGCGATCTATGGGCACCCGTTGTTTCCTCTGTTAGCTCTGGTCTTTGAGAAGTGCGAGCTGGCGACCTGCACTCCCCGGG
AACCTGGAGTGGCTGGCGGAGACGTCTGCTCCTCCGACTCCTTCAACGAGGACATCGCGGTCTTCGCCAAGCAGGTTCGCGCCGAAAAGC
CACTTTTTTCCTCAAATCCAGAGCTGGACAATTTGATGATACAAGCAATACAAGTACTAAGGTTTCATCTTTTGGAGTTAGAAAAGGTCC
ACGAACTGTGCGATAACTTCTGCCACCGATACATTAGCTGTTTGAAGGGGAAAATGCCCATCGACCTCGTCATTGATGAAAGAGACGGCA
GCTCCAAGTCAGATCATGAAGAACTTTCAGGCTCCTCCACAAATCTCGCTGACCATAACCCTTCTTCTTGGCGAGACCACGATGATGCAA
CCTCAACCCACTCAGCAGGCACCCCAGGGCCCTCCAGTGGGGGCCATGCTTCCCAGAGCGGAGACAACAGCAGTGAGCAAGGGGATGGTT
TAGACAACAGTGTAGCTTCACCTGGTACAGGTGACGATGATGATCCGGATAAGGACAAAAAACGCCAGAAGAAAAGAGGCATTTTCCCCA
AAGTAGCAACAAATATCATGAGAGCATGGCTCTTCCAGCATCTCACACATCCGTACCCTTCCGAAGAGCAGAAGAAACAGTTAGCGCAAG
ACACAGGACTTACAATTCTCCAAGTAAACAACTGGATGGGGCAAATGCAATTGTGCTGGGGACATTGGGAGACATTTCTTCCCCTCTTGC
GATTATTGGTGGCAATTGTGCTCTGCAAGGTTTCAATCATGAAGGAAGTGATCTCTTTTGGACGGTTACTGGAGACAATGTTAATTCCTT
GGCCTTGTGTGACTTTGATGGTGATGGAAAGAAAGAGCTTCTTGTTGGATCTGAGGATTTTGATATCCGAGTTTTTAAGGAAGATGAGAT
TGTGGCAGAAATGACAGAAACAGAGATAGTCACCTCTCTTTGTCCCATGTATGGCAGTCGATTTGGTTATGCCCTTTCCAATGGCACAGT
TGGAGTTTATGACAAAACATCCCGATACTGGAGAATTAAATCGAAAAATCATGCCATGAGCATTCATGCTTTTGACCTTAATTCTGATGG
AGTGAATGAACTGATAACTGGTTGGTCCAATGGGAAGGTTGATGCTCGAAGTGACCGAACTGGGGAGGTCATCTTTAAGGACAATTTTTC
TTCTGCAATTGCCGGTGTGGTAGAGGGAGATTACCGGATGGATGGCCACATACAGTTAATCTGCTGCTCAGTGGATGGGGAAATCCGGGG
CTACCTGCCTGGCACGGCTGAGATGAGGGGCAACCTCATGGACACCAGTGCAGAGCAGGACCTGATCCGAGAGCTGAGTCAGAAGAAGCA
GAATCTGTTGCTGGAACTCCGTAACTATGAGGAAAATGCCAAGAACAATACTTCAAAAATGTTAAAGTCATGATGGGATACAGTGGACCA

>52891_52891_14_MEIS2-BBS2_MEIS2_chr15_37242525_ENST00000444725_BBS2_chr16_56545196_ENST00000561951_length(amino acids)=413AA_BP=331
MERRLMAQRYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNVMPASMGSAVNDALKRDKDAIYGHPL
FPLLALVFEKCELATCTPREPGVAGGDVCSSDSFNEDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRY
ISCLKGKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGHASQSGDNSSEQGDGLDNSVASPGTG
DDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWMGQMQLCWGHWETFLPLLRLLVAIVLCKV

--------------------------------------------------------------
>52891_52891_15_MEIS2-BBS2_MEIS2_chr15_37242525_ENST00000444725_BBS2_chr16_56545196_ENST00000568104_length(transcript)=4113nt_BP=2014nt
TCCCGCTCCCCACTCCCGGGATGTGTCTCCGCCGTACGACGGGCTATGGCCACCACGACTTCCGGGTTCCGTCATTTCGTTCTCCCGCCG
CCGACCCGCGCCGCCAAACTGAGGCTCTTCAATAAGCCAGGCAGCAGCCAACCTGCCAACACCTACTGACACTCACTCATCTCCCAGAGA
GAGAAAGAGAGCGAGAGAGAGCGAGCGCGAGAGAGCGAGCGCGAGTGAGAGCGAGCGAGCGAGCGAGAAAGAGAGAGAGGGAGAGACAAA
ATACCTACCAGGAAAGGGGGGGAGGAAGTCCAATTTTTGCAAACTATTCATTTTTTTTTCTTGATTTTTCTCACTGCTTTCTTTGAACAA
TACTTTAAAGAGAGAGGATCGTATTATAGATACCGCGGGGGCAAAGCTAAAAAAGGGGGGAGGGGGGAGGAAAAAATTCAAGAAGCAGAA
ACCCCTCGCGGAGTTTTACTGGAAGAAAAAAACGGGTCTGAAAGATTCCTCCTCTTCATCATCATCAACCATCATTCATTCACTACCTTG
ACATTCCGGGCTTTGATTGACAGCTGGAGTGGCAAAAAGCCATGAAACACGACAGTTCGGTTACATGTGGGCTGCTGACGGGCCGCTCGT
AACCTTCAGTTCGGGGGCTTGACAATTTTTTTCTTCTTTTTCTTCTTTTTCTTTTCTTTCTTTTTTTTTCCAACTGAGGGGAAGAGAAGA
GAAAGAGGGGGAAAGGAGGACCGAAGAGGAGGAGGAGGGGAGGGGGGAGGAGGAGGAGGTGGAGGAGGAGGAGGAAGATCAGGAGGAGGA
GGAAGAAGAGGAAAAAAGAGAAAAAGAAGAAATATCACAGAAAAAAAAATTCTTCGTTGTCTAGACTGGGCTTTTTTTCCCCCCTAAAAA
ATAGCATATTGGAGAATTGGGAGAAGTCTCTTTGGTTTGGAAAAAAAAAAAAGGAATCTTCAGCCTAGATCACTTTCTTATCCGGACTGG
GATATTAAATATACGACACATCCAGGAGTTTATTGGAGCGCAGACTGATGGCGCAAAGGTACGATGAGCTGCCCCATTACGGCGGGATGG
ACGGAGTAGGGGTTCCCGCTTCCATGTACGGAGACCCTCACGCGCCGCGGCCGATCCCCCCGGTTCACCACCTGAACCACGGGCCGCCGC
TCCACGCCACACAGCACTACGGCGCGCACGCCCCGCACCCCAATGTCATGCCGGCCAGTATGGGATCCGCTGTCAACGACGCCTTGAAGC
GGGACAAGGACGCGATCTATGGGCACCCGTTGTTTCCTCTGTTAGCTCTGGTCTTTGAGAAGTGCGAGCTGGCGACCTGCACTCCCCGGG
AACCTGGAGTGGCTGGCGGAGACGTCTGCTCCTCCGACTCCTTCAACGAGGACATCGCGGTCTTCGCCAAGCAGGTTCGCGCCGAAAAGC
CACTTTTTTCCTCAAATCCAGAGCTGGACAATTTGATGATACAAGCAATACAAGTACTAAGGTTTCATCTTTTGGAGTTAGAAAAGGTCC
ACGAACTGTGCGATAACTTCTGCCACCGATACATTAGCTGTTTGAAGGGGAAAATGCCCATCGACCTCGTCATTGATGAAAGAGACGGCA
GCTCCAAGTCAGATCATGAAGAACTTTCAGGCTCCTCCACAAATCTCGCTGACCATAACCCTTCTTCTTGGCGAGACCACGATGATGCAA
CCTCAACCCACTCAGCAGGCACCCCAGGGCCCTCCAGTGGGGGCCATGCTTCCCAGAGCGGAGACAACAGCAGTGAGCAAGGGGATGGTT
TAGACAACAGTGTAGCTTCACCTGGTACAGGTGACGATGATGATCCGGATAAGGACAAAAAACGCCAGAAGAAAAGAGGCATTTTCCCCA
AAGTAGCAACAAATATCATGAGAGCATGGCTCTTCCAGCATCTCACACATCCGTACCCTTCCGAAGAGCAGAAGAAACAGTTAGCGCAAG
ACACAGGACTTACAATTCTCCAAGTAAACAACTGGTAGCAGATGGGGCAAATGCAATTGTGCTGGGGACATTGGGAGACATTTCTTCCCC
TCTTGCGATTATTGGTGGCAATTGTGCTCTGCAAGGTTTCAATCATGAAGGAAGTGATCTCTTTTGGACGGTTACTGGAGACAATGTTAA
TTCCTTGGCCTTGTGTGACTTTGATGGTGATGGAAAGAAAGAGCTTCTTGTTGGATCTGAGGATTTTGATATCCGAGTTTTTAAGGAAGA
TGAGATTGTGGCAGAAATGACAGAAACAGAGATAGTCACCTCTCTTTGTCCCATGTATGGCAGTCGATTTGGTTATGCCCTTTCCAATGG
CACAGTTGGAGTTTATGACAAAACATCCCGATACTGGAGAATTAAATCGAAAAATCATGCCATGAGCATTCATGCTTTTGACCTTAATTC
TGATGGAGTGAATGAACTGATAACTGGTTGGTCCAATGGGAAGGTTGATGCTCGAAGTGACCGAACTGGGGAGGTCATCTTTAAGGACAA
TTTTTCTTCTGCAATTGCCGGTGTGGTAGAGGGAGATTACCGGATGGATGGCCACATACAGTTAATCTGCTGCTCAGTGGATGGGGAAAT
CCGGGGCTACCTGCCTGGCACGGCTGAGATGAGGGGCAACCTCATGGACACCAGTGCAGAGCAGGACCTGATCCGAGAGCTGAGTCAGAA
GAAGCAGAATCTGTTGCTGGAACTCCGTAACTATGAGGAAAATGCCAAGGCTGAATTGGCCAGTCCACTGAACGAGGCTGATGGGCATCG
GGGCATAATCCCAGCCAATACCAGGCTCCACACCACGCTCTCAGTCAGCCTGGGGAATGAGACCCAAACTGCTCATACAGAATTACGCAT
TTCCACTTCTAATGACACCATCATCCGAGCAGTATTGATTTTTGCAGAAGGAATTTTTACAGGTGAAAGCCACGTGGTACATCCCAGCAT
TCACAACCTCTCCAGTTCCATCTGCATCCCTATTGTGCCTCCCAAAGATGTCCCTGTGGATCTGCACTTGAAGGCATTCGTGGGTTACAG
AAGCAGCACCCAGTTTCATGTATTTGAATCGACAAGACAGCTCCCTCGATTCTCCATGTATGCGCTGACCAGCCTGGACCCTGCCAGTGA
GCCAATCAGTTATGTTAACTTTACCATTGCAGAACGGGCACAGAGGGTTGTTGTATGGCTCGGTCAGAACTTTCTGTTACCAGAAGACAC
TCACATTCAGAATGCTCCATTTCAAGTGTGTTTCACATCTTTACGGAATGGCGGCCACCTGCATATAAAAATAAAACTTAGTGGAGAGGT
GGATGAATATCATTCAGTGCATCAGAAGCTCAGTGCTGATATGGCTGATCATTCTAATTTGATCCGAAGTTTGCTGGTCGGAGCTGAGGA
TGCTCGTCTGATGAGGGACATGAAAACAATGAAGAGTCGTTATATGGAACTCTATGACCTTAATAGAGACTTGCTAAATGGATATAAAAT
TCGCTGTAACAATCACACAGAGCTGTTGGGAAACCTCAAAGCAGTAAATCAAGCAATTCAAAGAGCAGGTCGTCTGCGGGTTGGAAAACC
AAAGAACCAGGTGATCACTGCTTGTCGGGATGCAATTCGAAGCAATAACATCAACACACTGTTCAAAATCATGCGAGTGGGGACAGCTTC
TTCCTAGGTGAGGAAAATACAGGTCATGAAGTTCCTGGCAAAGATTTTCTGTTAAAAACCTATGCTGGTTTGCTTTGGATCACACCCTGG
TGAACCCCGGGTGCTAAGAATGAAAATAACCTTGGTGAGTTGTACAAATTAAAGACAAAGAACTACATGTGAAGATAGACTTGCTTTCTA
TTTTTAAATCAGTAGTAGTACTGTTGCTGAATAATACTAGGTTTTTATGGAATAGGATGAATGCTTTTGAAGTATTAGGGCTTCAGAGTC
CAATTTTGCTTATTTATGGTATATAAATACATATTTTTTTCTTGAAATTGCAATTGAGTTTGTACTTTTCAAATAGATTATCTACTTTTT

>52891_52891_15_MEIS2-BBS2_MEIS2_chr15_37242525_ENST00000444725_BBS2_chr16_56545196_ENST00000568104_length(amino acids)=593AA_BP=33
MALPASHTSVPFRRAEETVSARHRTYNSPSKQLVADGANAIVLGTLGDISSPLAIIGGNCALQGFNHEGSDLFWTVTGDNVNSLALCDFD
GDGKKELLVGSEDFDIRVFKEDEIVAEMTETEIVTSLCPMYGSRFGYALSNGTVGVYDKTSRYWRIKSKNHAMSIHAFDLNSDGVNELIT
GWSNGKVDARSDRTGEVIFKDNFSSAIAGVVEGDYRMDGHIQLICCSVDGEIRGYLPGTAEMRGNLMDTSAEQDLIRELSQKKQNLLLEL
RNYEENAKAELASPLNEADGHRGIIPANTRLHTTLSVSLGNETQTAHTELRISTSNDTIIRAVLIFAEGIFTGESHVVHPSIHNLSSSIC
IPIVPPKDVPVDLHLKAFVGYRSSTQFHVFESTRQLPRFSMYALTSLDPASEPISYVNFTIAERAQRVVVWLGQNFLLPEDTHIQNAPFQ
VCFTSLRNGGHLHIKIKLSGEVDEYHSVHQKLSADMADHSNLIRSLLVGAEDARLMRDMKTMKSRYMELYDLNRDLLNGYKIRCNNHTEL

--------------------------------------------------------------
>52891_52891_16_MEIS2-BBS2_MEIS2_chr15_37242525_ENST00000559085_BBS2_chr16_56545196_ENST00000245157_length(transcript)=3265nt_BP=1068nt
CTTTTCTGTTCGCCCTCTTCTCCCTGCTCTTTTTCCCTTTCCACCCCCCTCCTCTGTTCTCCCTCACCTCCTGCGCCCCCTCCCCCTTCC
CGGGTTCTGACAGTACGATGAGCTGCCCCATTACGGCGGGATGGACGGAGTAGGGGTTCCCGCTTCCATGTACGGAGACCCTCACGCGCC
GCGGCCGATCCCCCCGGTTCACCACCTGAACCACGGGCCGCCGCTCCACGCCACACAGCACTACGGCGCGCACGCCCCGCACCCCAATGT
CATGCCGGCCAGTATGGGATCCGCTGTCAACGACGCCTTGAAGCGGGACAAGGACGCGATCTATGGGCACCCGTTGTTTCCTCTGTTAGC
TCTGGTCTTTGAGAAGTGCGAGCTGGCGACCTGCACTCCCCGGGAACCTGGAGTGGCTGGCGGAGACGTCTGCTCCTCCGACTCCTTCAA
CGAGGACATCGCGGTCTTCGCCAAGCAGGTTCGCGCCGAAAAGCCACTTTTTTCCTCAAATCCAGAGCTGGACAATTTGATGATACAAGC
AATACAAGTACTAAGGTTTCATCTTTTGGAGTTAGAAAAGGTCCACGAACTGTGCGATAACTTCTGCCACCGATACATTAGCTGTTTGAA
GGGGAAAATGCCCATCGACCTCGTCATTGATGAAAGAGACGGCAGCTCCAAGTCAGATCATGAAGAACTTTCAGGCTCCTCCACAAATCT
CGCTGACCATAACCCTTCTTCTTGGCGAGACCACGATGATGCAACCTCAACCCACTCAGCAGGCACCCCAGGGCCCTCCAGTGGGGGCCA
TGCTTCCCAGAGCGGAGACAACAGCAGTGAGCAAGGGGATGGTTTAGACAACAGTGTAGCTTCACCTGGTACAGGTGACGATGATGATCC
GGATAAGGACAAAAAACGCCAGAAGAAAAGAGGCATTTTCCCCAAAGTAGCAACAAATATCATGAGAGCATGGCTCTTCCAGCATCTCAC
ACATCCGTACCCTTCCGAAGAGCAGAAGAAACAGTTAGCGCAAGACACAGGACTTACAATTCTCCAAGTAAACAACTGGTAGCAGATGGG
GCAAATGCAATTGTGCTGGGGACATTGGGAGACATTTCTTCCCCTCTTGCGATTATTGGTGGCAATTGTGCTCTGCAAGGTTTCAATCAT
GAAGGAAGTGATCTCTTTTGGACGGTTACTGGAGACAATGTTAATTCCTTGGCCTTGTGTGACTTTGATGGTGATGGAAAGAAAGAGCTT
CTTGTTGGATCTGAGGATTTTGATATCCGAGTTTTTAAGGAAGATGAGATTGTGGCAGAAATGACAGAAACAGAGATAGTCACCTCTCTT
TGTCCCATGTATGGCAGTCGATTTGGTTATGCCCTTTCCAATGGCACAGTTGGAGTTTATGACAAAACATCCCGATACTGGAGAATTAAA
TCGAAAAATCATGCCATGAGCATTCATGCTTTTGACCTTAATTCTGATGGAGTGAATGAACTGATAACTGGTTGGTCCAATGGGAAGGTT
GATGCTCGAAGTGACCGAACTGGGGAGGTCATCTTTAAGGACAATTTTTCTTCTGCAATTGCCGGTGTGGTAGAGGGAGATTACCGGATG
GATGGCCACATACAGTTAATCTGCTGCTCAGTGGATGGGGAAATCCGGGGCTACCTGCCTGGCACGGCTGAGATGAGGGGCAACCTCATG
GACACCAGTGCAGAGCAGGACCTGATCCGAGAGCTGAGTCAGAAGAAGCAGAATCTGTTGCTGGAACTCCGTAACTATGAGGAAAATGCC
AAGGCTGAATTGGCCAGTCCACTGAACGAGGCTGATGGGCATCGGGGCATAATCCCAGCCAATACCAGGCTCCACACCACGCTCTCAGTC
AGCCTGGGGAATGAGACCCAAACTGCTCATACAGAATTACGCATTTCCACTTCTAATGACACCATCATCCGAGCAGTATTGATTTTTGCA
GAAGGAATTTTTACAGGTGAAAGCCACGTGGTACATCCCAGCATTCACAACCTCTCCAGTTCCATCTGCATCCCTATTGTGCCTCCCAAA
GATGTCCCTGTGGATCTGCACTTGAAGGCATTCGTGGGTTACAGAAGCAGCACCCAGTTTCATGTATTTGAATCGACAAGACAGCTCCCT
CGATTCTCCATGTATGCGCTGACCAGCCTGGACCCTGCCAGTGAGCCAATCAGTTATGTTAACTTTACCATTGCAGAACGGGCACAGAGG
GTTGTTGTATGGCTCGGTCAGAACTTTCTGTTACCAGAAGACACTCACATTCAGAATGCTCCATTTCAAGTGTGTTTCACATCTTTACGG
AATGGCGGCCACCTGCATATAAAAATAAAACTTAGTGGAGAGATCACTATAAATACTGATGATATTGATTTGGCTGGTGATATCATCCAG
TCAATGGCATCATTTTTTGCTATTGAAGACCTTCAAGTAGAAGCGGATTTTCCTGTCTATTTTGAGGAATTACGAAAGGTGCTAGTTAAG
GTGGATGAATATCATTCAGTGCATCAGAAGCTCAGTGCTGATATGGCTGATCATTCTAATTTGATCCGAAGTTTGCTGGTCGGAGCTGAG
GATGCTCGTCTGATGAGGGACATGAAAACAATGAAGAGTCGTTATATGGAACTCTATGACCTTAATAGAGACTTGCTAAATGGATATAAA
ATTCGCTGTAACAATCACACAGAGCTGTTGGGAAACCTCAAAGCAGTAAATCAAGCAATTCAAAGAGCAGGTCGTCTGCGGGTTGGAAAA
CCAAAGAACCAGGTGATCACTGCTTGTCGGGATGCAATTCGAAGCAATAACATCAACACACTGTTCAAAATCATGCGAGTGGGGACAGCT
TCTTCCTAGGTGAGGAAAATACAGGTCATGAAGTTCCTGGCAAAGATTTTCTGTTAAAAACCTATGCTGGTTTGCTTTGGATCACACCCT
GGTGAACCCCGGGTGCTAAGAATGAAAATAACCTTGGTGAGTTGTACAAATTAAAGACAAAGAACTACATGTGAAGATAGACTTGCTTTC
TATTTTTAAATCAGTAGTAGTACTGTTGCTGAATAATACTAGGTTTTTATGGAATAGGATGAATGCTTTTGAAGTATTAGGGCTTCAGAG
TCCAATTTTGCTTATTTATGGTATATAAATACATATTTTTTTCTTGAAATTGCAATTGAGTTTGTACTTTTCAAATAGATTATCTACTTT

>52891_52891_16_MEIS2-BBS2_MEIS2_chr15_37242525_ENST00000559085_BBS2_chr16_56545196_ENST00000245157_length(amino acids)=639AA_BP=33
MALPASHTSVPFRRAEETVSARHRTYNSPSKQLVADGANAIVLGTLGDISSPLAIIGGNCALQGFNHEGSDLFWTVTGDNVNSLALCDFD
GDGKKELLVGSEDFDIRVFKEDEIVAEMTETEIVTSLCPMYGSRFGYALSNGTVGVYDKTSRYWRIKSKNHAMSIHAFDLNSDGVNELIT
GWSNGKVDARSDRTGEVIFKDNFSSAIAGVVEGDYRMDGHIQLICCSVDGEIRGYLPGTAEMRGNLMDTSAEQDLIRELSQKKQNLLLEL
RNYEENAKAELASPLNEADGHRGIIPANTRLHTTLSVSLGNETQTAHTELRISTSNDTIIRAVLIFAEGIFTGESHVVHPSIHNLSSSIC
IPIVPPKDVPVDLHLKAFVGYRSSTQFHVFESTRQLPRFSMYALTSLDPASEPISYVNFTIAERAQRVVVWLGQNFLLPEDTHIQNAPFQ
VCFTSLRNGGHLHIKIKLSGEITINTDDIDLAGDIIQSMASFFAIEDLQVEADFPVYFEELRKVLVKVDEYHSVHQKLSADMADHSNLIR
SLLVGAEDARLMRDMKTMKSRYMELYDLNRDLLNGYKIRCNNHTELLGNLKAVNQAIQRAGRLRVGKPKNQVITACRDAIRSNNINTLFK

--------------------------------------------------------------
>52891_52891_17_MEIS2-BBS2_MEIS2_chr15_37242525_ENST00000559085_BBS2_chr16_56545196_ENST00000561951_length(transcript)=1913nt_BP=1068nt
CTTTTCTGTTCGCCCTCTTCTCCCTGCTCTTTTTCCCTTTCCACCCCCCTCCTCTGTTCTCCCTCACCTCCTGCGCCCCCTCCCCCTTCC
CGGGTTCTGACAGTACGATGAGCTGCCCCATTACGGCGGGATGGACGGAGTAGGGGTTCCCGCTTCCATGTACGGAGACCCTCACGCGCC
GCGGCCGATCCCCCCGGTTCACCACCTGAACCACGGGCCGCCGCTCCACGCCACACAGCACTACGGCGCGCACGCCCCGCACCCCAATGT
CATGCCGGCCAGTATGGGATCCGCTGTCAACGACGCCTTGAAGCGGGACAAGGACGCGATCTATGGGCACCCGTTGTTTCCTCTGTTAGC
TCTGGTCTTTGAGAAGTGCGAGCTGGCGACCTGCACTCCCCGGGAACCTGGAGTGGCTGGCGGAGACGTCTGCTCCTCCGACTCCTTCAA
CGAGGACATCGCGGTCTTCGCCAAGCAGGTTCGCGCCGAAAAGCCACTTTTTTCCTCAAATCCAGAGCTGGACAATTTGATGATACAAGC
AATACAAGTACTAAGGTTTCATCTTTTGGAGTTAGAAAAGGTCCACGAACTGTGCGATAACTTCTGCCACCGATACATTAGCTGTTTGAA
GGGGAAAATGCCCATCGACCTCGTCATTGATGAAAGAGACGGCAGCTCCAAGTCAGATCATGAAGAACTTTCAGGCTCCTCCACAAATCT
CGCTGACCATAACCCTTCTTCTTGGCGAGACCACGATGATGCAACCTCAACCCACTCAGCAGGCACCCCAGGGCCCTCCAGTGGGGGCCA
TGCTTCCCAGAGCGGAGACAACAGCAGTGAGCAAGGGGATGGTTTAGACAACAGTGTAGCTTCACCTGGTACAGGTGACGATGATGATCC
GGATAAGGACAAAAAACGCCAGAAGAAAAGAGGCATTTTCCCCAAAGTAGCAACAAATATCATGAGAGCATGGCTCTTCCAGCATCTCAC
ACATCCGTACCCTTCCGAAGAGCAGAAGAAACAGTTAGCGCAAGACACAGGACTTACAATTCTCCAAGTAAACAACTGGATGGGGCAAAT
GCAATTGTGCTGGGGACATTGGGAGACATTTCTTCCCCTCTTGCGATTATTGGTGGCAATTGTGCTCTGCAAGGTTTCAATCATGAAGGA
AGTGATCTCTTTTGGACGGTTACTGGAGACAATGTTAATTCCTTGGCCTTGTGTGACTTTGATGGTGATGGAAAGAAAGAGCTTCTTGTT
GGATCTGAGGATTTTGATATCCGAGTTTTTAAGGAAGATGAGATTGTGGCAGAAATGACAGAAACAGAGATAGTCACCTCTCTTTGTCCC
ATGTATGGCAGTCGATTTGGTTATGCCCTTTCCAATGGCACAGTTGGAGTTTATGACAAAACATCCCGATACTGGAGAATTAAATCGAAA
AATCATGCCATGAGCATTCATGCTTTTGACCTTAATTCTGATGGAGTGAATGAACTGATAACTGGTTGGTCCAATGGGAAGGTTGATGCT
CGAAGTGACCGAACTGGGGAGGTCATCTTTAAGGACAATTTTTCTTCTGCAATTGCCGGTGTGGTAGAGGGAGATTACCGGATGGATGGC
CACATACAGTTAATCTGCTGCTCAGTGGATGGGGAAATCCGGGGCTACCTGCCTGGCACGGCTGAGATGAGGGGCAACCTCATGGACACC
AGTGCAGAGCAGGACCTGATCCGAGAGCTGAGTCAGAAGAAGCAGAATCTGTTGCTGGAACTCCGTAACTATGAGGAAAATGCCAAGAAC
AATACTTCAAAAATGTTAAAGTCATGATGGGATACAGTGGACCATACCCATAGAAAGATGCAAGGGTATTTTCCCACAGGGCCAGATAGA

>52891_52891_17_MEIS2-BBS2_MEIS2_chr15_37242525_ENST00000559085_BBS2_chr16_56545196_ENST00000561951_length(amino acids)=401AA_BP=319
MPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNVMPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCE
LATCTPREPGVAGGDVCSSDSFNEDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDL
VIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGHASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKRQ
KKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWMGQMQLCWGHWETFLPLLRLLVAIVLCKVSIMKEVISFGRL

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>52891_52891_18_MEIS2-BBS2_MEIS2_chr15_37242525_ENST00000559085_BBS2_chr16_56545196_ENST00000568104_length(transcript)=3167nt_BP=1068nt
CTTTTCTGTTCGCCCTCTTCTCCCTGCTCTTTTTCCCTTTCCACCCCCCTCCTCTGTTCTCCCTCACCTCCTGCGCCCCCTCCCCCTTCC
CGGGTTCTGACAGTACGATGAGCTGCCCCATTACGGCGGGATGGACGGAGTAGGGGTTCCCGCTTCCATGTACGGAGACCCTCACGCGCC
GCGGCCGATCCCCCCGGTTCACCACCTGAACCACGGGCCGCCGCTCCACGCCACACAGCACTACGGCGCGCACGCCCCGCACCCCAATGT
CATGCCGGCCAGTATGGGATCCGCTGTCAACGACGCCTTGAAGCGGGACAAGGACGCGATCTATGGGCACCCGTTGTTTCCTCTGTTAGC
TCTGGTCTTTGAGAAGTGCGAGCTGGCGACCTGCACTCCCCGGGAACCTGGAGTGGCTGGCGGAGACGTCTGCTCCTCCGACTCCTTCAA
CGAGGACATCGCGGTCTTCGCCAAGCAGGTTCGCGCCGAAAAGCCACTTTTTTCCTCAAATCCAGAGCTGGACAATTTGATGATACAAGC
AATACAAGTACTAAGGTTTCATCTTTTGGAGTTAGAAAAGGTCCACGAACTGTGCGATAACTTCTGCCACCGATACATTAGCTGTTTGAA
GGGGAAAATGCCCATCGACCTCGTCATTGATGAAAGAGACGGCAGCTCCAAGTCAGATCATGAAGAACTTTCAGGCTCCTCCACAAATCT
CGCTGACCATAACCCTTCTTCTTGGCGAGACCACGATGATGCAACCTCAACCCACTCAGCAGGCACCCCAGGGCCCTCCAGTGGGGGCCA
TGCTTCCCAGAGCGGAGACAACAGCAGTGAGCAAGGGGATGGTTTAGACAACAGTGTAGCTTCACCTGGTACAGGTGACGATGATGATCC
GGATAAGGACAAAAAACGCCAGAAGAAAAGAGGCATTTTCCCCAAAGTAGCAACAAATATCATGAGAGCATGGCTCTTCCAGCATCTCAC
ACATCCGTACCCTTCCGAAGAGCAGAAGAAACAGTTAGCGCAAGACACAGGACTTACAATTCTCCAAGTAAACAACTGGTAGCAGATGGG
GCAAATGCAATTGTGCTGGGGACATTGGGAGACATTTCTTCCCCTCTTGCGATTATTGGTGGCAATTGTGCTCTGCAAGGTTTCAATCAT
GAAGGAAGTGATCTCTTTTGGACGGTTACTGGAGACAATGTTAATTCCTTGGCCTTGTGTGACTTTGATGGTGATGGAAAGAAAGAGCTT
CTTGTTGGATCTGAGGATTTTGATATCCGAGTTTTTAAGGAAGATGAGATTGTGGCAGAAATGACAGAAACAGAGATAGTCACCTCTCTT
TGTCCCATGTATGGCAGTCGATTTGGTTATGCCCTTTCCAATGGCACAGTTGGAGTTTATGACAAAACATCCCGATACTGGAGAATTAAA
TCGAAAAATCATGCCATGAGCATTCATGCTTTTGACCTTAATTCTGATGGAGTGAATGAACTGATAACTGGTTGGTCCAATGGGAAGGTT
GATGCTCGAAGTGACCGAACTGGGGAGGTCATCTTTAAGGACAATTTTTCTTCTGCAATTGCCGGTGTGGTAGAGGGAGATTACCGGATG
GATGGCCACATACAGTTAATCTGCTGCTCAGTGGATGGGGAAATCCGGGGCTACCTGCCTGGCACGGCTGAGATGAGGGGCAACCTCATG
GACACCAGTGCAGAGCAGGACCTGATCCGAGAGCTGAGTCAGAAGAAGCAGAATCTGTTGCTGGAACTCCGTAACTATGAGGAAAATGCC
AAGGCTGAATTGGCCAGTCCACTGAACGAGGCTGATGGGCATCGGGGCATAATCCCAGCCAATACCAGGCTCCACACCACGCTCTCAGTC
AGCCTGGGGAATGAGACCCAAACTGCTCATACAGAATTACGCATTTCCACTTCTAATGACACCATCATCCGAGCAGTATTGATTTTTGCA
GAAGGAATTTTTACAGGTGAAAGCCACGTGGTACATCCCAGCATTCACAACCTCTCCAGTTCCATCTGCATCCCTATTGTGCCTCCCAAA
GATGTCCCTGTGGATCTGCACTTGAAGGCATTCGTGGGTTACAGAAGCAGCACCCAGTTTCATGTATTTGAATCGACAAGACAGCTCCCT
CGATTCTCCATGTATGCGCTGACCAGCCTGGACCCTGCCAGTGAGCCAATCAGTTATGTTAACTTTACCATTGCAGAACGGGCACAGAGG
GTTGTTGTATGGCTCGGTCAGAACTTTCTGTTACCAGAAGACACTCACATTCAGAATGCTCCATTTCAAGTGTGTTTCACATCTTTACGG
AATGGCGGCCACCTGCATATAAAAATAAAACTTAGTGGAGAGGTGGATGAATATCATTCAGTGCATCAGAAGCTCAGTGCTGATATGGCT
GATCATTCTAATTTGATCCGAAGTTTGCTGGTCGGAGCTGAGGATGCTCGTCTGATGAGGGACATGAAAACAATGAAGAGTCGTTATATG
GAACTCTATGACCTTAATAGAGACTTGCTAAATGGATATAAAATTCGCTGTAACAATCACACAGAGCTGTTGGGAAACCTCAAAGCAGTA
AATCAAGCAATTCAAAGAGCAGGTCGTCTGCGGGTTGGAAAACCAAAGAACCAGGTGATCACTGCTTGTCGGGATGCAATTCGAAGCAAT
AACATCAACACACTGTTCAAAATCATGCGAGTGGGGACAGCTTCTTCCTAGGTGAGGAAAATACAGGTCATGAAGTTCCTGGCAAAGATT
TTCTGTTAAAAACCTATGCTGGTTTGCTTTGGATCACACCCTGGTGAACCCCGGGTGCTAAGAATGAAAATAACCTTGGTGAGTTGTACA
AATTAAAGACAAAGAACTACATGTGAAGATAGACTTGCTTTCTATTTTTAAATCAGTAGTAGTACTGTTGCTGAATAATACTAGGTTTTT
ATGGAATAGGATGAATGCTTTTGAAGTATTAGGGCTTCAGAGTCCAATTTTGCTTATTTATGGTATATAAATACATATTTTTTTCTTGAA
ATTGCAATTGAGTTTGTACTTTTCAAATAGATTATCTACTTTTTCATTAAAATGTAAAGATGTTAAACTTTGTGTTGATTGATTATAAAA

>52891_52891_18_MEIS2-BBS2_MEIS2_chr15_37242525_ENST00000559085_BBS2_chr16_56545196_ENST00000568104_length(amino acids)=593AA_BP=33
MALPASHTSVPFRRAEETVSARHRTYNSPSKQLVADGANAIVLGTLGDISSPLAIIGGNCALQGFNHEGSDLFWTVTGDNVNSLALCDFD
GDGKKELLVGSEDFDIRVFKEDEIVAEMTETEIVTSLCPMYGSRFGYALSNGTVGVYDKTSRYWRIKSKNHAMSIHAFDLNSDGVNELIT
GWSNGKVDARSDRTGEVIFKDNFSSAIAGVVEGDYRMDGHIQLICCSVDGEIRGYLPGTAEMRGNLMDTSAEQDLIRELSQKKQNLLLEL
RNYEENAKAELASPLNEADGHRGIIPANTRLHTTLSVSLGNETQTAHTELRISTSNDTIIRAVLIFAEGIFTGESHVVHPSIHNLSSSIC
IPIVPPKDVPVDLHLKAFVGYRSSTQFHVFESTRQLPRFSMYALTSLDPASEPISYVNFTIAERAQRVVVWLGQNFLLPEDTHIQNAPFQ
VCFTSLRNGGHLHIKIKLSGEVDEYHSVHQKLSADMADHSNLIRSLLVGAEDARLMRDMKTMKSRYMELYDLNRDLLNGYKIRCNNHTEL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MEIS2-BBS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneMEIS2chr15:37242525chr16:56545196ENST00000424352-913299_333325.6666666666667201.0DNA


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMEIS2chr15:37242525chr16:56545196ENST00000338564-1013299_333325.6666666666667471.0DNA
HgeneMEIS2chr15:37242525chr16:56545196ENST00000340545-913299_333312.6666666666667675.0DNA
HgeneMEIS2chr15:37242525chr16:56545196ENST00000382766-912299_333325.6666666666667471.0DNA
HgeneMEIS2chr15:37242525chr16:56545196ENST00000397620-913299_333237.66666666666666300.0DNA
HgeneMEIS2chr15:37242525chr16:56545196ENST00000397624-812299_333237.66666666666666657.3333333333334DNA
HgeneMEIS2chr15:37242525chr16:56545196ENST00000444725-913299_333325.6666666666667475.6666666666667DNA
HgeneMEIS2chr15:37242525chr16:56545196ENST00000557796-913299_333312.6666666666667551.0DNA
HgeneMEIS2chr15:37242525chr16:56545196ENST00000559085-812299_333312.6666666666667663.0DNA
HgeneMEIS2chr15:37242525chr16:56545196ENST00000559561-912299_333325.6666666666667395.0DNA
HgeneMEIS2chr15:37242525chr16:56545196ENST00000561208-912299_333325.6666666666667478.0DNA


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MEIS2-BBS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MEIS2-BBS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource