|
||||||
|
 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:MEIS2-DOC2B (FusionGDB2 ID:52895) |
Fusion Gene Summary for MEIS2-DOC2B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MEIS2-DOC2B | Fusion gene ID: 52895 | Hgene | Tgene | Gene symbol | MEIS2 | DOC2B | Gene ID | 4212 | 8447 |
| Gene name | Meis homeobox 2 | double C2 domain beta | |
| Synonyms | CPCMR|HsT18361|MRG1 | DOC2BL | |
| Cytomap | 15q14 | 17p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | homeobox protein Meis2Meis homolog 2Meis1, myeloid ecotropic viral integration site 1 homolog 2Meis1-related gene 1TALE homeobox protein Meis2meis1-related protein 1 | double C2-like domain-containing protein betadoc2-betadouble C2-like domains, beta | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | O14770 | Q14184 | |
| Ensembl transtripts involved in fusion gene | ENST00000219869, ENST00000338564, ENST00000340545, ENST00000382766, ENST00000397620, ENST00000397624, ENST00000424352, ENST00000444725, ENST00000557796, ENST00000559085, ENST00000559408, ENST00000559561, ENST00000561208, | ENST00000343572, ENST00000609727, | |
| Fusion gene scores | * DoF score | 25 X 16 X 6=2400 | 2 X 2 X 1=4 |
| # samples | 27 | 2 | |
| ** MAII score | log2(27/2400*10)=-3.15200309344505 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: MEIS2 [Title/Abstract] AND DOC2B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | MEIS2(37228585)-DOC2B(26849), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MEIS2 | GO:0045931 | positive regulation of mitotic cell cycle | 26512644 |
| Hgene | MEIS2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 10764806 |
| Hgene | MEIS2 | GO:0110024 | positive regulation of cardiac muscle myoblast proliferation | 26512644 |
| Fusion gene breakpoints across MEIS2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across DOC2B (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS5.0 | N/A | AV710980 | MEIS2 | chr15 | 37228585 | - | DOC2B | chr17 | 26849 | - |
Top |
Fusion Gene ORF analysis for MEIS2-DOC2B |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000219869 | ENST00000343572 | MEIS2 | chr15 | 37228585 | - | DOC2B | chr17 | 26849 | - |
| intron-intron | ENST00000219869 | ENST00000609727 | MEIS2 | chr15 | 37228585 | - | DOC2B | chr17 | 26849 | - |
| intron-intron | ENST00000338564 | ENST00000343572 | MEIS2 | chr15 | 37228585 | - | DOC2B | chr17 | 26849 | - |
| intron-intron | ENST00000338564 | ENST00000609727 | MEIS2 | chr15 | 37228585 | - | DOC2B | chr17 | 26849 | - |
| intron-intron | ENST00000340545 | ENST00000343572 | MEIS2 | chr15 | 37228585 | - | DOC2B | chr17 | 26849 | - |
| intron-intron | ENST00000340545 | ENST00000609727 | MEIS2 | chr15 | 37228585 | - | DOC2B | chr17 | 26849 | - |
| intron-intron | ENST00000382766 | ENST00000343572 | MEIS2 | chr15 | 37228585 | - | DOC2B | chr17 | 26849 | - |
| intron-intron | ENST00000382766 | ENST00000609727 | MEIS2 | chr15 | 37228585 | - | DOC2B | chr17 | 26849 | - |
| intron-intron | ENST00000397620 | ENST00000343572 | MEIS2 | chr15 | 37228585 | - | DOC2B | chr17 | 26849 | - |
| intron-intron | ENST00000397620 | ENST00000609727 | MEIS2 | chr15 | 37228585 | - | DOC2B | chr17 | 26849 | - |
| intron-intron | ENST00000397624 | ENST00000343572 | MEIS2 | chr15 | 37228585 | - | DOC2B | chr17 | 26849 | - |
| intron-intron | ENST00000397624 | ENST00000609727 | MEIS2 | chr15 | 37228585 | - | DOC2B | chr17 | 26849 | - |
| intron-intron | ENST00000424352 | ENST00000343572 | MEIS2 | chr15 | 37228585 | - | DOC2B | chr17 | 26849 | - |
| intron-intron | ENST00000424352 | ENST00000609727 | MEIS2 | chr15 | 37228585 | - | DOC2B | chr17 | 26849 | - |
| intron-intron | ENST00000444725 | ENST00000343572 | MEIS2 | chr15 | 37228585 | - | DOC2B | chr17 | 26849 | - |
| intron-intron | ENST00000444725 | ENST00000609727 | MEIS2 | chr15 | 37228585 | - | DOC2B | chr17 | 26849 | - |
| intron-intron | ENST00000557796 | ENST00000343572 | MEIS2 | chr15 | 37228585 | - | DOC2B | chr17 | 26849 | - |
| intron-intron | ENST00000557796 | ENST00000609727 | MEIS2 | chr15 | 37228585 | - | DOC2B | chr17 | 26849 | - |
| intron-intron | ENST00000559085 | ENST00000343572 | MEIS2 | chr15 | 37228585 | - | DOC2B | chr17 | 26849 | - |
| intron-intron | ENST00000559085 | ENST00000609727 | MEIS2 | chr15 | 37228585 | - | DOC2B | chr17 | 26849 | - |
| intron-intron | ENST00000559408 | ENST00000343572 | MEIS2 | chr15 | 37228585 | - | DOC2B | chr17 | 26849 | - |
| intron-intron | ENST00000559408 | ENST00000609727 | MEIS2 | chr15 | 37228585 | - | DOC2B | chr17 | 26849 | - |
| intron-intron | ENST00000559561 | ENST00000343572 | MEIS2 | chr15 | 37228585 | - | DOC2B | chr17 | 26849 | - |
| intron-intron | ENST00000559561 | ENST00000609727 | MEIS2 | chr15 | 37228585 | - | DOC2B | chr17 | 26849 | - |
| intron-intron | ENST00000561208 | ENST00000343572 | MEIS2 | chr15 | 37228585 | - | DOC2B | chr17 | 26849 | - |
| intron-intron | ENST00000561208 | ENST00000609727 | MEIS2 | chr15 | 37228585 | - | DOC2B | chr17 | 26849 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
Top |
Fusion Genomic Features for MEIS2-DOC2B |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
Top |
Fusion Protein Features for MEIS2-DOC2B |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:37228585/:26849) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MEIS2 | DOC2B |
| FUNCTION: Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3 and isoform 4 can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5 cannot activate DRD1 transcription. {ECO:0000269|PubMed:10764806, ECO:0000269|PubMed:11279116, ECO:0000269|PubMed:21746878}. | FUNCTION: Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes (By similarity). {ECO:0000250, ECO:0000269|PubMed:9804756}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
Fusion Gene Sequence for MEIS2-DOC2B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
Top |
Fusion Gene PPI Analysis for MEIS2-DOC2B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for MEIS2-DOC2B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for MEIS2-DOC2B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies