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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MELK-CAMK2D (FusionGDB2 ID:52925)

Fusion Gene Summary for MELK-CAMK2D

Fusion gene summary

Fusion gene information	Fusion gene name: MELK-CAMK2D
	Fusion gene ID: 52925
		Hgene	Tgene
	Gene symbol	MELK	CAMK2D
	Gene ID	9833	817
	Gene name	maternal embryonic leucine zipper kinase	calcium/calmodulin dependent protein kinase II delta
	Synonyms	HPK38	CAMKD
	Cytomap	9p13.2	4q26
	Type of gene	protein-coding	protein-coding
	Description	maternal embryonic leucine zipper kinasepEg3 kinaseprotein kinase Eg3protein kinase PK38tyrosine-protein kinase MELK	calcium/calmodulin-dependent protein kinase type II subunit deltaCaM kinase II delta subunitCaM-kinase II delta chainCaMK-II delta subunitcalcium/calmodulin-dependent protein kinase (CaM kinase) II deltacalcium/calmodulin-dependent protein kinase typ
	Modification date	20200322	20200327
	UniProtAcc	Q14680	Q13557
	Ensembl transtripts involved in fusion gene	ENST00000298048, ENST00000487398, ENST00000536329, ENST00000536860, ENST00000536987, ENST00000538311, ENST00000541717, ENST00000543751, ENST00000545008,	ENST00000296402, ENST00000394524, ENST00000394526, ENST00000418639, ENST00000429180, ENST00000454265, ENST00000342666, ENST00000379773, ENST00000394522, ENST00000505990, ENST00000508738, ENST00000509907, ENST00000511664, ENST00000514328, ENST00000515496,
Fusion gene scores	* DoF score	45 X 20 X 4=3600	5 X 4 X 3=60
	# samples	47	5
	** MAII score	log2(47/3600*10)=-2.93726424465204 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MELK [Title/Abstract] AND CAMK2D [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MELK(36616841)-CAMK2D(114373574), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MELK	GO:0006915	apoptotic process	17280616
Hgene	MELK	GO:0008283	cell proliferation	17280616
Hgene	MELK	GO:0046777	protein autophosphorylation	16216881
Tgene	CAMK2D	GO:0003254	regulation of membrane depolarization	22514276
Tgene	CAMK2D	GO:0006468	protein phosphorylation	17179159\|23283722
Tgene	CAMK2D	GO:0018105	peptidyl-serine phosphorylation	22514276\|23283722
Tgene	CAMK2D	GO:0018107	peptidyl-threonine phosphorylation	22514276\|23283722
Tgene	CAMK2D	GO:0046777	protein autophosphorylation	22514276
Tgene	CAMK2D	GO:1901897	regulation of relaxation of cardiac muscle	23283722
Tgene	CAMK2D	GO:1902306	negative regulation of sodium ion transmembrane transport	22514276
Tgene	CAMK2D	GO:2000650	negative regulation of sodium ion transmembrane transporter activity	22514276

Fusion gene breakpoints across MELK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CAMK2D (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BI492715	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+

Top

Fusion Gene ORF analysis for MELK-CAMK2D

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3UTR	ENST00000298048	ENST00000296402	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000298048	ENST00000394524	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000298048	ENST00000394526	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000298048	ENST00000418639	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000298048	ENST00000429180	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000298048	ENST00000454265	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000487398	ENST00000296402	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000487398	ENST00000394524	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000487398	ENST00000394526	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000487398	ENST00000418639	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000487398	ENST00000429180	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000487398	ENST00000454265	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000536329	ENST00000296402	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000536329	ENST00000394524	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000536329	ENST00000394526	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000536329	ENST00000418639	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000536329	ENST00000429180	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000536329	ENST00000454265	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000536860	ENST00000296402	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000536860	ENST00000394524	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000536860	ENST00000394526	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000536860	ENST00000418639	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000536860	ENST00000429180	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000536860	ENST00000454265	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000536987	ENST00000296402	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000536987	ENST00000394524	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000536987	ENST00000394526	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000536987	ENST00000418639	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000536987	ENST00000429180	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000536987	ENST00000454265	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000538311	ENST00000296402	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000538311	ENST00000394524	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000538311	ENST00000394526	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000538311	ENST00000418639	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000538311	ENST00000429180	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000538311	ENST00000454265	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000541717	ENST00000296402	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000541717	ENST00000394524	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000541717	ENST00000394526	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000541717	ENST00000418639	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000541717	ENST00000429180	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000541717	ENST00000454265	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000543751	ENST00000296402	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000543751	ENST00000394524	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000543751	ENST00000394526	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000543751	ENST00000418639	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000543751	ENST00000429180	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000543751	ENST00000454265	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000545008	ENST00000296402	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000545008	ENST00000394524	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000545008	ENST00000394526	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000545008	ENST00000418639	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000545008	ENST00000429180	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-3UTR	ENST00000545008	ENST00000454265	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000298048	ENST00000342666	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000298048	ENST00000379773	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000298048	ENST00000394522	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000298048	ENST00000505990	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000298048	ENST00000508738	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000298048	ENST00000509907	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000298048	ENST00000511664	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000298048	ENST00000514328	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000298048	ENST00000515496	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000487398	ENST00000342666	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000487398	ENST00000379773	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000487398	ENST00000394522	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000487398	ENST00000505990	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000487398	ENST00000508738	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000487398	ENST00000509907	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000487398	ENST00000511664	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000487398	ENST00000514328	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000487398	ENST00000515496	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000536329	ENST00000342666	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000536329	ENST00000379773	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000536329	ENST00000394522	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000536329	ENST00000505990	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000536329	ENST00000508738	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000536329	ENST00000509907	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000536329	ENST00000511664	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000536329	ENST00000514328	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000536329	ENST00000515496	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000536860	ENST00000342666	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000536860	ENST00000379773	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000536860	ENST00000394522	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000536860	ENST00000505990	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000536860	ENST00000508738	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000536860	ENST00000509907	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000536860	ENST00000511664	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000536860	ENST00000514328	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000536860	ENST00000515496	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000536987	ENST00000342666	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000536987	ENST00000379773	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000536987	ENST00000394522	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000536987	ENST00000505990	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000536987	ENST00000508738	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000536987	ENST00000509907	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000536987	ENST00000511664	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000536987	ENST00000514328	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000536987	ENST00000515496	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000538311	ENST00000342666	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000538311	ENST00000379773	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000538311	ENST00000394522	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000538311	ENST00000505990	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000538311	ENST00000508738	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000538311	ENST00000509907	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000538311	ENST00000511664	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000538311	ENST00000514328	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000538311	ENST00000515496	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000541717	ENST00000342666	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000541717	ENST00000379773	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000541717	ENST00000394522	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000541717	ENST00000505990	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000541717	ENST00000508738	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000541717	ENST00000509907	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000541717	ENST00000511664	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000541717	ENST00000514328	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000541717	ENST00000515496	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000543751	ENST00000342666	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000543751	ENST00000379773	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000543751	ENST00000394522	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000543751	ENST00000505990	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000543751	ENST00000508738	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000543751	ENST00000509907	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000543751	ENST00000511664	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000543751	ENST00000514328	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000543751	ENST00000515496	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000545008	ENST00000342666	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000545008	ENST00000379773	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000545008	ENST00000394522	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000545008	ENST00000505990	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000545008	ENST00000508738	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000545008	ENST00000509907	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000545008	ENST00000511664	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000545008	ENST00000514328	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+
intron-intron	ENST00000545008	ENST00000515496	MELK	chr9	36616841	+	CAMK2D	chr4	114373574	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for MELK-CAMK2D

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MELK-CAMK2D

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:36616841/:114373574)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MELK Q14680	CAMK2D Q13557
FUNCTION: Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis. {ECO:0000269\|PubMed:11802789, ECO:0000269\|PubMed:12400006, ECO:0000269\|PubMed:14699119, ECO:0000269\|PubMed:15908796, ECO:0000269\|PubMed:16216881, ECO:0000269\|PubMed:17280616}.	FUNCTION: Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. {ECO:0000269\|PubMed:16690701, ECO:0000269\|PubMed:17179159}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for MELK-CAMK2D

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MELK-CAMK2D

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for MELK-CAMK2D

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for MELK-CAMK2D

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source