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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MELK-FKBP9 (FusionGDB2 ID:52931)

Fusion Gene Summary for MELK-FKBP9

check button Fusion gene summary
Fusion gene informationFusion gene name: MELK-FKBP9
Fusion gene ID: 52931
HgeneTgene
Gene symbol

MELK

FKBP9

Gene ID

9833

11328

Gene namematernal embryonic leucine zipper kinaseFKBP prolyl isomerase 9
SynonymsHPK38FKBP60|FKBP63|PPIase
Cytomap

9p13.2

7p14.3

Type of geneprotein-codingprotein-coding
Descriptionmaternal embryonic leucine zipper kinasepEg3 kinaseprotein kinase Eg3protein kinase PK38tyrosine-protein kinase MELKpeptidyl-prolyl cis-trans isomerase FKBP963 kDa FK506-binding protein63 kDa FKBPFK506 binding protein 9, 63 kDaFK506-binding protein 9FKBP-63FKBP-9PPIase FKBP9rotamase
Modification date2020032220200313
UniProtAcc

Q14680

Q75LS8

Ensembl transtripts involved in fusion geneENST00000298048, ENST00000487398, 
ENST00000536329, ENST00000536860, 
ENST00000536987, ENST00000538311, 
ENST00000541717, ENST00000543751, 
ENST00000545008, 		ENST00000242209, 
ENST00000489038, ENST00000490776, 
ENST00000538336, ENST00000538443, 
Fusion gene scores* DoF score45 X 20 X 4=36006 X 5 X 4=120
# samples 476
** MAII scorelog2(47/3600*10)=-2.93726424465204
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MELK [Title/Abstract] AND FKBP9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMELK(36616841)-FKBP9(33046540), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMELK

GO:0006915

apoptotic process

17280616

HgeneMELK

GO:0008283

cell proliferation

17280616

HgeneMELK

GO:0046777

protein autophosphorylation

16216881


check buttonFusion gene breakpoints across MELK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FKBP9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABI496190MELKchr9

36616841

+FKBP9chr7

33046540

-


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Fusion Gene ORF analysis for MELK-FKBP9

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000298048ENST00000242209MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000298048ENST00000489038MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000298048ENST00000490776MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000298048ENST00000538336MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000298048ENST00000538443MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000487398ENST00000242209MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000487398ENST00000489038MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000487398ENST00000490776MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000487398ENST00000538336MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000487398ENST00000538443MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000536329ENST00000242209MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000536329ENST00000489038MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000536329ENST00000490776MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000536329ENST00000538336MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000536329ENST00000538443MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000536860ENST00000242209MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000536860ENST00000489038MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000536860ENST00000490776MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000536860ENST00000538336MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000536860ENST00000538443MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000536987ENST00000242209MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000536987ENST00000489038MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000536987ENST00000490776MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000536987ENST00000538336MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000536987ENST00000538443MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000538311ENST00000242209MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000538311ENST00000489038MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000538311ENST00000490776MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000538311ENST00000538336MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000538311ENST00000538443MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000541717ENST00000242209MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000541717ENST00000489038MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000541717ENST00000490776MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000541717ENST00000538336MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000541717ENST00000538443MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000543751ENST00000242209MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000543751ENST00000489038MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000543751ENST00000490776MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000543751ENST00000538336MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000543751ENST00000538443MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000545008ENST00000242209MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000545008ENST00000489038MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000545008ENST00000490776MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000545008ENST00000538336MELKchr9

36616841

+FKBP9chr7

33046540

-
intron-intronENST00000545008ENST00000538443MELKchr9

36616841

+FKBP9chr7

33046540

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MELK-FKBP9


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MELK-FKBP9


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:36616841/:33046540)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MELK

Q14680

FKBP9

Q75LS8

FUNCTION: Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis. {ECO:0000269|PubMed:11802789, ECO:0000269|PubMed:12400006, ECO:0000269|PubMed:14699119, ECO:0000269|PubMed:15908796, ECO:0000269|PubMed:16216881, ECO:0000269|PubMed:17280616}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MELK-FKBP9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MELK-FKBP9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MELK-FKBP9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MELK-FKBP9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource