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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:METAP1-IQGAP1 (FusionGDB2 ID:53009)

Fusion Gene Summary for METAP1-IQGAP1

check button Fusion gene summary
Fusion gene informationFusion gene name: METAP1-IQGAP1
Fusion gene ID: 53009
HgeneTgene
Gene symbol

METAP1

IQGAP1

Gene ID

23173

8826

Gene namemethionyl aminopeptidase 1IQ motif containing GTPase activating protein 1
SynonymsMAP1A|MetAP1AHUMORFA01|SAR1|p195
Cytomap

4q23

15q26.1

Type of geneprotein-codingprotein-coding
Descriptionmethionine aminopeptidase 1MAP 1metAP 1peptidase M 1ras GTPase-activating-like protein IQGAP1RasGAP-like with IQ motifs
Modification date2020031320200327
UniProtAcc

P53582

P46940

Ensembl transtripts involved in fusion geneENST00000296411, ENST00000544031, 
ENST00000506548, 		ENST00000560020, 
ENST00000268182, ENST00000560738, 
Fusion gene scores* DoF score3 X 3 X 3=2717 X 15 X 7=1785
# samples 319
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(19/1785*10)=-3.23185275058551
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: METAP1 [Title/Abstract] AND IQGAP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMETAP1(99966461)-IQGAP1(91030186), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneIQGAP1

GO:0071277

cellular response to calcium ion

18567582


check buttonFusion gene breakpoints across METAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across IQGAP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-EQ-A4SO-01AMETAP1chr4

99966461

+IQGAP1chr15

91030186

+


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Fusion Gene ORF analysis for METAP1-IQGAP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000296411ENST00000560020METAP1chr4

99966461

+IQGAP1chr15

91030186

+
5CDS-intronENST00000544031ENST00000560020METAP1chr4

99966461

+IQGAP1chr15

91030186

+
In-frameENST00000296411ENST00000268182METAP1chr4

99966461

+IQGAP1chr15

91030186

+
In-frameENST00000296411ENST00000560738METAP1chr4

99966461

+IQGAP1chr15

91030186

+
In-frameENST00000544031ENST00000268182METAP1chr4

99966461

+IQGAP1chr15

91030186

+
In-frameENST00000544031ENST00000560738METAP1chr4

99966461

+IQGAP1chr15

91030186

+
intron-3CDSENST00000506548ENST00000268182METAP1chr4

99966461

+IQGAP1chr15

91030186

+
intron-3CDSENST00000506548ENST00000560738METAP1chr4

99966461

+IQGAP1chr15

91030186

+
intron-intronENST00000506548ENST00000560020METAP1chr4

99966461

+IQGAP1chr15

91030186

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000296411METAP1chr499966461+ENST00000268182IQGAP1chr1591030186+40069211341870578
ENST00000296411METAP1chr499966461+ENST00000560738IQGAP1chr1591030186+21349211341870578
ENST00000544031METAP1chr499966461+ENST00000268182IQGAP1chr1591030186+372263701586528
ENST00000544031METAP1chr499966461+ENST00000560738IQGAP1chr1591030186+185063701586528

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000296411ENST00000268182METAP1chr499966461+IQGAP1chr1591030186+0.0002659830.999734
ENST00000296411ENST00000560738METAP1chr499966461+IQGAP1chr1591030186+0.0016224780.99837756
ENST00000544031ENST00000268182METAP1chr499966461+IQGAP1chr1591030186+0.0003653320.9996346
ENST00000544031ENST00000560738METAP1chr499966461+IQGAP1chr1591030186+0.0018862820.99811375

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Fusion Genomic Features for METAP1-IQGAP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for METAP1-IQGAP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:99966461/chr15:91030186)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
METAP1

P53582

IQGAP1

P46940

FUNCTION: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle. {ECO:0000255|HAMAP-Rule:MF_03174, ECO:0000269|PubMed:16274222, ECO:0000269|PubMed:17114291}.FUNCTION: Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816). {ECO:0000269|PubMed:15695813, ECO:0000269|PubMed:20883816}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMETAP1chr4:99966461chr15:91030186ENST00000296411+8119_52262387.0RegionZinc finger-like%3B important for proper ribosome association

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneIQGAP1chr4:99966461chr15:91030186ENST0000026818230381004_123713411658.0DomainRas-GAP
TgeneIQGAP1chr4:99966461chr15:91030186ENST00000268182303844_15913411658.0DomainCalponin-homology (CH)
TgeneIQGAP1chr4:99966461chr15:91030186ENST000002681823038679_71213411658.0DomainWW
TgeneIQGAP1chr4:99966461chr15:91030186ENST000002681823038745_77413411658.0DomainIQ 1
TgeneIQGAP1chr4:99966461chr15:91030186ENST000002681823038775_80413411658.0DomainIQ 2
TgeneIQGAP1chr4:99966461chr15:91030186ENST000002681823038805_83413411658.0DomainIQ 3
TgeneIQGAP1chr4:99966461chr15:91030186ENST000002681823038835_86413411658.0DomainIQ 4
TgeneIQGAP1chr4:99966461chr15:91030186ENST0000026818230381276_165713411658.0RegionNote=C2
TgeneIQGAP1chr4:99966461chr15:91030186ENST000002681823038956_127413411658.0RegionNote=C1


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Fusion Gene Sequence for METAP1-IQGAP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>53009_53009_1_METAP1-IQGAP1_METAP1_chr4_99966461_ENST00000296411_IQGAP1_chr15_91030186_ENST00000268182_length(transcript)=4006nt_BP=921nt
CTCCCGCGCCCAGGCCAGCGGCGGGCCCAGCTCCTCCCCCGACTCGGTCTCTCTCCCCTCCCCTCCGCCCGGCAGTTCCTCCCTCCCGCC
GCCGCCTCTTCCTCGGTGAGGCGCTCTTCCAGCGGGCAGGCAGCATGGCGGCCGTGGAGACGCGGGTGTGCGAGACAGACGGCTGCAGCA
GTGAGGCCAAGCTCCAGTGTCCCACTTGCATCAAGCTGGGCATCCAGGGCTCGTACTTCTGCTCGCAGGAATGTTTTAAAGGAAGTTGGG
CTACTCACAAGTTACTACATAAGAAAGCAAAAGATGAAAAGGCGAAGCGAGAAGTGTCTTCCTGGACTGTGGAAGGTGATATTAATACTG
ACCCATGGGCAGGTTATCGATATACTGGTAAACTCAGACCACATTATCCACTGATGCCAACAAGGCCAGTGCCAAGTTATATTCAAAGAC
CAGATTATGCTGATCATCCCTTAGGAATGTCTGAATCTGAACAGGCTCTTAAAGGTACTTCTCAGATTAAATTACTCTCATCTGAAGATA
TAGAAGGGATGCGACTTGTATGTAGGCTTGCTAGAGAAGTTTTGGATGTTGCTGCCGGCATGATTAAACCAGGTGTAACTACTGAAGAAA
TAGATCACGCTGTACACTTAGCATGTATTGCAAGAAATTGCTACCCTTCTCCCCTGAATTATTATAATTTCCCAAAGTCTTGTTGTACCT
CAGTGAATGAAGTCATTTGCCATGGAATACCAGACAGAAGGCCCTTACAAGAAGGTGACATTGTTAATGTGGATATCACTCTTTATCGCA
ATGGTTATCATGGGGACCTGAATGAGACATTTTTTGTTGGAGAAGTGGATGATGGAGCACGGAAACTTGTTCAGACCACATATGAGTGCC
TGATGCAAGCCATTGATGCAGGGGAAAGCTCTGGCAATTTAAATGACCCAAATAAGGAGGCACTGGCTAAGACGGAAGTGTCTCTCACCC
TGACCAACAAGTTCGACGTGCCTGGAGATGAGAATGCAGAAATGGATGCTCGAACCATCTTACTGAATACAAAACGTTTAATTGTGGATG
TCATCCGGTTCCAGCCAGGAGAGACCTTGACTGAAATCCTAGAAACACCAGCCACCAGTGAACAGGAAGCAGAACATCAGAGAGCCATGC
AGAGACGTGCTATCCGTGATGCCAAAACACCTGACAAGATGAAAAAGTCAAAATCTGTAAAGGAAGACAGCAACCTCACTCTTCAAGAGA
AGAAAGAGAAGATCCAGACAGGTTTAAAGAAGCTAACAGAGCTTGGAACCGTGGACCCAAAGAACAAATACCAGGAACTGATCAACGACA
TTGCCAGGGATATTCGGAATCAGCGGAGGTACCGACAGAGGAGAAAGGCCGAACTAGTGAAACTGCAACAGACATACGCTGCTCTGAACT
CTAAGGCCACCTTTTATGGGGAGCAGGTGGATTACTATAAAAGCTATATCAAAACCTGCTTGGATAACTTAGCCAGCAAGGGCAAAGTCT
CCAAAAAGCCTAGGGAAATGAAAGGAAAGAAAAGCAAAAAGATTTCTCTGAAATATACAGCAGCAAGACTACATGAAAAAGGAGTTCTTC
TGGAAATTGAGGACCTGCAAGTGAATCAGTTTAAAAATGTTATATTTGAAATCAGTCCAACAGAAGAAGTTGGAGACTTCGAAGTGAAAG
CCAAATTCATGGGAGTTCAAATGGAGACTTTTATGTTACATTATCAGGACCTGCTGCAGCTACAGTATGAAGGAGTTGCAGTCATGAAAT
TATTTGATAGAGCTAAAGTAAATGTCAACCTCCTGATCTTCCTTCTCAACAAAAAGTTCTACGGGAAGTAATTGATCGTTTGCTGCCAGC
CCAGAAGGATGAAGGAAAGAAGCACCTCACAGCTCCTTTCTAGGTCCTTCTTTCCTCATTGGAAGCAAAGACCTAGCCAACAACAGCACC
TCAATCTGATACACTCCCGATGCCACATTTTTAACTCCTCTCGCTCTGATGGGACATTTGTTACCCTTTTTTCATAGTGAAATTGTGTTT
CAGGCTTAGTCTGACCTTTCTGGTTTCTTCATTTTCTTCCATTACTTAGGAAAGAGTGGAAACTCCACTAAAATTTCTCTGTGTTGTTAC
AGTCTTAGAGGTTGCAGTACTATATTGTAAGCTTTGGTGTTTGTTTAATTAGCAATAGGGATGGTAGGATTCAAATGTGTGTCATTTAGA
AGTGGAAGCTATTAGCACCAATGACATAAATACATACAAGACACACAACTAAAATGTCATGTTATTAACAGTTATTAGGTTGTCATTTAA
AAATAAAGTTCCTTTATATTTCTGTCCCATCAGGAAAACTGAAGGATATGGGGAATCATTGGTTATCTTCCATTGTGTTTTTCTTTATGG
ACAGGAGCTAATGGAAGTGACAGTCATGTTCAAAGGAAGCATTTCTAGAAAAAAGGAGATAATGTTTTTAAATTTCATTATCAAACTTGG
GCAATTCTGTTTGTGTAACTCCCCGACTAGTGGATGGGAGAGTCCCATTGCTAAAATTCAGCTACTCAGATAAATTCAGAATGGGTCAAG
GCACCTGCCTGTTTTTGTTGGTGCACAGAGATTGACTTGATTCAGAGAGACAATTCACTCCATCCCTATGGCAGAGGAATGGGTTAGCCC
TAATGTAGAATGTCATTGTTTTTAAAACTGTTTTATATCTTAAGAGTGCCTTATTAAAGTATAGATGTATGTCTTAAAATGTGGGTGATA
GGAATTTTAAAGATTTATATAATGCATCAAAAGCCTTAGAATAAGAAAAGCTTTTTTTAAATTGCTTTATCTGTATATCTGAACTCTTGA
AACTTATAGCTAAAACACTAGGATTTATCTGCAGTGTTCAGGGAGATAATTCTGCCTTTAATTGTCTAAAACAAAAACAAAACCAGCCAA
CCTATGTTACACGTGAGATTAAAACCAATTTTTTCCCCATTTTTTCTCCTTTTTTCTCTTGCTGCCCACATTGTGCCTTTATTTTATGAG
CCCCAGTTTTCTGGGCTTAGTTTAAAAAAAAAATCAAGTCTAAACATTGCATTTAGAAAGCTTTTGTTCTTGGATAAAAAGTCATACACT
TTAAAAAAAAAAAAAACTTTTTCCAGGAAAATATATTGAAATCATGCTGCTGAGCCTCTATTTTCTTTCTTTGATGTTTTGATTCAGTAT
TCTTTTATCATAAATTTTTAGCATTTAAAAATTCACTGATGTACATTAAGCCAATAAACTGCTTTAATGAATAACAAACTATGTAGTGTG
TCCCTATTATAAATGCATTGGAGAAGTATTTTTATGAGACTCTTTACTCAGGTGCATGGTTACAGCCCACAGGGAGGCATGGAGTGCCAT
GGAAGGATTCGCCACTACCCAGACCTTGTTTTTTGTTGTATTTTGGAAGACAGGTTTTTTAAAGAAACATTTTCCTCAGATTAAAAGATG
ATGCTATTACAACTAGCATTGCCTCAAAAACTGGGACCAACCAAAGTGTGTCAACCCTGTTTCCTTAAAAGAGGCTATGAATCCCAAAGG
CCACATCCAAGACAGGCAATAATGAGCAGAGTTTACAGCTCCTTTAATAAAATGTGTCAGTAATTTTAAGGTTTATAGTTCCCTCAACAC
AATTGCTAATGCAGAATAGTGTAAAATGCGCTTCAAGAATGTTGATGATGATGATATAGAATTGTGGCTTTAGTAGCACAGAGGATGCCC
CAACAAACTCATGGCGTTGAAACCACACAGTTCTCATTACTGTTATTTATTAGCTGTAGCATTCTCTGTCTCCTCTCTCTCCTCCTTTGA
CCTTCTCCTCGACCAGCCATCATGACATTTACCATGAATTTACTTCCTCCCAAGAGTTTGGACTGCCCGTCAGATTGTTGCTGCACATAG

>53009_53009_1_METAP1-IQGAP1_METAP1_chr4_99966461_ENST00000296411_IQGAP1_chr15_91030186_ENST00000268182_length(amino acids)=578AA_BP=262
MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKAKREVSSWTVEGDINTDPWAGYRYTGKLRPH
YPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCY
PSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAGESSGNLN
DPNKEALAKTEVSLTLTNKFDVPGDENAEMDARTILLNTKRLIVDVIRFQPGETLTEILETPATSEQEAEHQRAMQRRAIRDAKTPDKMK
KSKSVKEDSNLTLQEKKEKIQTGLKKLTELGTVDPKNKYQELINDIARDIRNQRRYRQRRKAELVKLQQTYAALNSKATFYGEQVDYYKS
YIKTCLDNLASKGKVSKKPREMKGKKSKKISLKYTAARLHEKGVLLEIEDLQVNQFKNVIFEISPTEEVGDFEVKAKFMGVQMETFMLHY

--------------------------------------------------------------
>53009_53009_2_METAP1-IQGAP1_METAP1_chr4_99966461_ENST00000296411_IQGAP1_chr15_91030186_ENST00000560738_length(transcript)=2134nt_BP=921nt
CTCCCGCGCCCAGGCCAGCGGCGGGCCCAGCTCCTCCCCCGACTCGGTCTCTCTCCCCTCCCCTCCGCCCGGCAGTTCCTCCCTCCCGCC
GCCGCCTCTTCCTCGGTGAGGCGCTCTTCCAGCGGGCAGGCAGCATGGCGGCCGTGGAGACGCGGGTGTGCGAGACAGACGGCTGCAGCA
GTGAGGCCAAGCTCCAGTGTCCCACTTGCATCAAGCTGGGCATCCAGGGCTCGTACTTCTGCTCGCAGGAATGTTTTAAAGGAAGTTGGG
CTACTCACAAGTTACTACATAAGAAAGCAAAAGATGAAAAGGCGAAGCGAGAAGTGTCTTCCTGGACTGTGGAAGGTGATATTAATACTG
ACCCATGGGCAGGTTATCGATATACTGGTAAACTCAGACCACATTATCCACTGATGCCAACAAGGCCAGTGCCAAGTTATATTCAAAGAC
CAGATTATGCTGATCATCCCTTAGGAATGTCTGAATCTGAACAGGCTCTTAAAGGTACTTCTCAGATTAAATTACTCTCATCTGAAGATA
TAGAAGGGATGCGACTTGTATGTAGGCTTGCTAGAGAAGTTTTGGATGTTGCTGCCGGCATGATTAAACCAGGTGTAACTACTGAAGAAA
TAGATCACGCTGTACACTTAGCATGTATTGCAAGAAATTGCTACCCTTCTCCCCTGAATTATTATAATTTCCCAAAGTCTTGTTGTACCT
CAGTGAATGAAGTCATTTGCCATGGAATACCAGACAGAAGGCCCTTACAAGAAGGTGACATTGTTAATGTGGATATCACTCTTTATCGCA
ATGGTTATCATGGGGACCTGAATGAGACATTTTTTGTTGGAGAAGTGGATGATGGAGCACGGAAACTTGTTCAGACCACATATGAGTGCC
TGATGCAAGCCATTGATGCAGGGGAAAGCTCTGGCAATTTAAATGACCCAAATAAGGAGGCACTGGCTAAGACGGAAGTGTCTCTCACCC
TGACCAACAAGTTCGACGTGCCTGGAGATGAGAATGCAGAAATGGATGCTCGAACCATCTTACTGAATACAAAACGTTTAATTGTGGATG
TCATCCGGTTCCAGCCAGGAGAGACCTTGACTGAAATCCTAGAAACACCAGCCACCAGTGAACAGGAAGCAGAACATCAGAGAGCCATGC
AGAGACGTGCTATCCGTGATGCCAAAACACCTGACAAGATGAAAAAGTCAAAATCTGTAAAGGAAGACAGCAACCTCACTCTTCAAGAGA
AGAAAGAGAAGATCCAGACAGGTTTAAAGAAGCTAACAGAGCTTGGAACCGTGGACCCAAAGAACAAATACCAGGAACTGATCAACGACA
TTGCCAGGGATATTCGGAATCAGCGGAGGTACCGACAGAGGAGAAAGGCCGAACTAGTGAAACTGCAACAGACATACGCTGCTCTGAACT
CTAAGGCCACCTTTTATGGGGAGCAGGTGGATTACTATAAAAGCTATATCAAAACCTGCTTGGATAACTTAGCCAGCAAGGGCAAAGTCT
CCAAAAAGCCTAGGGAAATGAAAGGAAAGAAAAGCAAAAAGATTTCTCTGAAATATACAGCAGCAAGACTACATGAAAAAGGAGTTCTTC
TGGAAATTGAGGACCTGCAAGTGAATCAGTTTAAAAATGTTATATTTGAAATCAGTCCAACAGAAGAAGTTGGAGACTTCGAAGTGAAAG
CCAAATTCATGGGAGTTCAAATGGAGACTTTTATGTTACATTATCAGGACCTGCTGCAGCTACAGTATGAAGGAGTTGCAGTCATGAAAT
TATTTGATAGAGCTAAAGTAAATGTCAACCTCCTGATCTTCCTTCTCAACAAAAAGTTCTACGGGAAGTAATTGATCGTTTGCTGCCAGC
CCAGAAGGATGAAGGAAAGAAGCACCTCACAGCTCCTTTCTAGGTCCTTCTTTCCTCATTGGAAGCAAAGACCTAGCCAACAACAGCACC
TCAATCTGATACACTCCCGATGCCACATTTTTAACTCCTCTCGCTCTGATGGGACATTTGTTACCCTTTTTTCATAGTGAAATTGTGTTT

>53009_53009_2_METAP1-IQGAP1_METAP1_chr4_99966461_ENST00000296411_IQGAP1_chr15_91030186_ENST00000560738_length(amino acids)=578AA_BP=262
MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKAKREVSSWTVEGDINTDPWAGYRYTGKLRPH
YPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCY
PSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAGESSGNLN
DPNKEALAKTEVSLTLTNKFDVPGDENAEMDARTILLNTKRLIVDVIRFQPGETLTEILETPATSEQEAEHQRAMQRRAIRDAKTPDKMK
KSKSVKEDSNLTLQEKKEKIQTGLKKLTELGTVDPKNKYQELINDIARDIRNQRRYRQRRKAELVKLQQTYAALNSKATFYGEQVDYYKS
YIKTCLDNLASKGKVSKKPREMKGKKSKKISLKYTAARLHEKGVLLEIEDLQVNQFKNVIFEISPTEEVGDFEVKAKFMGVQMETFMLHY

--------------------------------------------------------------
>53009_53009_3_METAP1-IQGAP1_METAP1_chr4_99966461_ENST00000544031_IQGAP1_chr15_91030186_ENST00000268182_length(transcript)=3722nt_BP=637nt
ATGTGTACCATGCATAAAGATGAAAAGGCGAAGCGAGAAGTGTCTTCCTGGACTGTGGAAGGTGATATTAATACTGACCCATGGGCAGGT
TATCGATATACTGGTAAACTCAGACCACATTATCCACTGATGCCAACAAGGCCAGTGCCAAGTTATATTCAAAGACCAGATTATGCTGAT
CATCCCTTAGGAATGTCTGAATCTGAACAGGCTCTTAAAGGTACTTCTCAGATTAAATTACTCTCATCTGAAGATATAGAAGGGATGCGA
CTTGTATGTAGGCTTGCTAGAGAAGTTTTGGATGTTGCTGCCGGCATGATTAAACCAGGTGTAACTACTGAAGAAATAGATCACGCTGTA
CACTTAGCATGTATTGCAAGAAATTGCTACCCTTCTCCCCTGAATTATTATAATTTCCCAAAGTCTTGTTGTACCTCAGTGAATGAAGTC
ATTTGCCATGGAATACCAGACAGAAGGCCCTTACAAGAAGGTGACATTGTTAATGTGGATATCACTCTTTATCGCAATGGTTATCATGGG
GACCTGAATGAGACATTTTTTGTTGGAGAAGTGGATGATGGAGCACGGAAACTTGTTCAGACCACATATGAGTGCCTGATGCAAGCCATT
GATGCAGGGGAAAGCTCTGGCAATTTAAATGACCCAAATAAGGAGGCACTGGCTAAGACGGAAGTGTCTCTCACCCTGACCAACAAGTTC
GACGTGCCTGGAGATGAGAATGCAGAAATGGATGCTCGAACCATCTTACTGAATACAAAACGTTTAATTGTGGATGTCATCCGGTTCCAG
CCAGGAGAGACCTTGACTGAAATCCTAGAAACACCAGCCACCAGTGAACAGGAAGCAGAACATCAGAGAGCCATGCAGAGACGTGCTATC
CGTGATGCCAAAACACCTGACAAGATGAAAAAGTCAAAATCTGTAAAGGAAGACAGCAACCTCACTCTTCAAGAGAAGAAAGAGAAGATC
CAGACAGGTTTAAAGAAGCTAACAGAGCTTGGAACCGTGGACCCAAAGAACAAATACCAGGAACTGATCAACGACATTGCCAGGGATATT
CGGAATCAGCGGAGGTACCGACAGAGGAGAAAGGCCGAACTAGTGAAACTGCAACAGACATACGCTGCTCTGAACTCTAAGGCCACCTTT
TATGGGGAGCAGGTGGATTACTATAAAAGCTATATCAAAACCTGCTTGGATAACTTAGCCAGCAAGGGCAAAGTCTCCAAAAAGCCTAGG
GAAATGAAAGGAAAGAAAAGCAAAAAGATTTCTCTGAAATATACAGCAGCAAGACTACATGAAAAAGGAGTTCTTCTGGAAATTGAGGAC
CTGCAAGTGAATCAGTTTAAAAATGTTATATTTGAAATCAGTCCAACAGAAGAAGTTGGAGACTTCGAAGTGAAAGCCAAATTCATGGGA
GTTCAAATGGAGACTTTTATGTTACATTATCAGGACCTGCTGCAGCTACAGTATGAAGGAGTTGCAGTCATGAAATTATTTGATAGAGCT
AAAGTAAATGTCAACCTCCTGATCTTCCTTCTCAACAAAAAGTTCTACGGGAAGTAATTGATCGTTTGCTGCCAGCCCAGAAGGATGAAG
GAAAGAAGCACCTCACAGCTCCTTTCTAGGTCCTTCTTTCCTCATTGGAAGCAAAGACCTAGCCAACAACAGCACCTCAATCTGATACAC
TCCCGATGCCACATTTTTAACTCCTCTCGCTCTGATGGGACATTTGTTACCCTTTTTTCATAGTGAAATTGTGTTTCAGGCTTAGTCTGA
CCTTTCTGGTTTCTTCATTTTCTTCCATTACTTAGGAAAGAGTGGAAACTCCACTAAAATTTCTCTGTGTTGTTACAGTCTTAGAGGTTG
CAGTACTATATTGTAAGCTTTGGTGTTTGTTTAATTAGCAATAGGGATGGTAGGATTCAAATGTGTGTCATTTAGAAGTGGAAGCTATTA
GCACCAATGACATAAATACATACAAGACACACAACTAAAATGTCATGTTATTAACAGTTATTAGGTTGTCATTTAAAAATAAAGTTCCTT
TATATTTCTGTCCCATCAGGAAAACTGAAGGATATGGGGAATCATTGGTTATCTTCCATTGTGTTTTTCTTTATGGACAGGAGCTAATGG
AAGTGACAGTCATGTTCAAAGGAAGCATTTCTAGAAAAAAGGAGATAATGTTTTTAAATTTCATTATCAAACTTGGGCAATTCTGTTTGT
GTAACTCCCCGACTAGTGGATGGGAGAGTCCCATTGCTAAAATTCAGCTACTCAGATAAATTCAGAATGGGTCAAGGCACCTGCCTGTTT
TTGTTGGTGCACAGAGATTGACTTGATTCAGAGAGACAATTCACTCCATCCCTATGGCAGAGGAATGGGTTAGCCCTAATGTAGAATGTC
ATTGTTTTTAAAACTGTTTTATATCTTAAGAGTGCCTTATTAAAGTATAGATGTATGTCTTAAAATGTGGGTGATAGGAATTTTAAAGAT
TTATATAATGCATCAAAAGCCTTAGAATAAGAAAAGCTTTTTTTAAATTGCTTTATCTGTATATCTGAACTCTTGAAACTTATAGCTAAA
ACACTAGGATTTATCTGCAGTGTTCAGGGAGATAATTCTGCCTTTAATTGTCTAAAACAAAAACAAAACCAGCCAACCTATGTTACACGT
GAGATTAAAACCAATTTTTTCCCCATTTTTTCTCCTTTTTTCTCTTGCTGCCCACATTGTGCCTTTATTTTATGAGCCCCAGTTTTCTGG
GCTTAGTTTAAAAAAAAAATCAAGTCTAAACATTGCATTTAGAAAGCTTTTGTTCTTGGATAAAAAGTCATACACTTTAAAAAAAAAAAA
AACTTTTTCCAGGAAAATATATTGAAATCATGCTGCTGAGCCTCTATTTTCTTTCTTTGATGTTTTGATTCAGTATTCTTTTATCATAAA
TTTTTAGCATTTAAAAATTCACTGATGTACATTAAGCCAATAAACTGCTTTAATGAATAACAAACTATGTAGTGTGTCCCTATTATAAAT
GCATTGGAGAAGTATTTTTATGAGACTCTTTACTCAGGTGCATGGTTACAGCCCACAGGGAGGCATGGAGTGCCATGGAAGGATTCGCCA
CTACCCAGACCTTGTTTTTTGTTGTATTTTGGAAGACAGGTTTTTTAAAGAAACATTTTCCTCAGATTAAAAGATGATGCTATTACAACT
AGCATTGCCTCAAAAACTGGGACCAACCAAAGTGTGTCAACCCTGTTTCCTTAAAAGAGGCTATGAATCCCAAAGGCCACATCCAAGACA
GGCAATAATGAGCAGAGTTTACAGCTCCTTTAATAAAATGTGTCAGTAATTTTAAGGTTTATAGTTCCCTCAACACAATTGCTAATGCAG
AATAGTGTAAAATGCGCTTCAAGAATGTTGATGATGATGATATAGAATTGTGGCTTTAGTAGCACAGAGGATGCCCCAACAAACTCATGG
CGTTGAAACCACACAGTTCTCATTACTGTTATTTATTAGCTGTAGCATTCTCTGTCTCCTCTCTCTCCTCCTTTGACCTTCTCCTCGACC
AGCCATCATGACATTTACCATGAATTTACTTCCTCCCAAGAGTTTGGACTGCCCGTCAGATTGTTGCTGCACATAGTTGCCTTTGTATCT

>53009_53009_3_METAP1-IQGAP1_METAP1_chr4_99966461_ENST00000544031_IQGAP1_chr15_91030186_ENST00000268182_length(amino acids)=528AA_BP=212
MCTMHKDEKAKREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMR
LVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHG
DLNETFFVGEVDDGARKLVQTTYECLMQAIDAGESSGNLNDPNKEALAKTEVSLTLTNKFDVPGDENAEMDARTILLNTKRLIVDVIRFQ
PGETLTEILETPATSEQEAEHQRAMQRRAIRDAKTPDKMKKSKSVKEDSNLTLQEKKEKIQTGLKKLTELGTVDPKNKYQELINDIARDI
RNQRRYRQRRKAELVKLQQTYAALNSKATFYGEQVDYYKSYIKTCLDNLASKGKVSKKPREMKGKKSKKISLKYTAARLHEKGVLLEIED

--------------------------------------------------------------
>53009_53009_4_METAP1-IQGAP1_METAP1_chr4_99966461_ENST00000544031_IQGAP1_chr15_91030186_ENST00000560738_length(transcript)=1850nt_BP=637nt
ATGTGTACCATGCATAAAGATGAAAAGGCGAAGCGAGAAGTGTCTTCCTGGACTGTGGAAGGTGATATTAATACTGACCCATGGGCAGGT
TATCGATATACTGGTAAACTCAGACCACATTATCCACTGATGCCAACAAGGCCAGTGCCAAGTTATATTCAAAGACCAGATTATGCTGAT
CATCCCTTAGGAATGTCTGAATCTGAACAGGCTCTTAAAGGTACTTCTCAGATTAAATTACTCTCATCTGAAGATATAGAAGGGATGCGA
CTTGTATGTAGGCTTGCTAGAGAAGTTTTGGATGTTGCTGCCGGCATGATTAAACCAGGTGTAACTACTGAAGAAATAGATCACGCTGTA
CACTTAGCATGTATTGCAAGAAATTGCTACCCTTCTCCCCTGAATTATTATAATTTCCCAAAGTCTTGTTGTACCTCAGTGAATGAAGTC
ATTTGCCATGGAATACCAGACAGAAGGCCCTTACAAGAAGGTGACATTGTTAATGTGGATATCACTCTTTATCGCAATGGTTATCATGGG
GACCTGAATGAGACATTTTTTGTTGGAGAAGTGGATGATGGAGCACGGAAACTTGTTCAGACCACATATGAGTGCCTGATGCAAGCCATT
GATGCAGGGGAAAGCTCTGGCAATTTAAATGACCCAAATAAGGAGGCACTGGCTAAGACGGAAGTGTCTCTCACCCTGACCAACAAGTTC
GACGTGCCTGGAGATGAGAATGCAGAAATGGATGCTCGAACCATCTTACTGAATACAAAACGTTTAATTGTGGATGTCATCCGGTTCCAG
CCAGGAGAGACCTTGACTGAAATCCTAGAAACACCAGCCACCAGTGAACAGGAAGCAGAACATCAGAGAGCCATGCAGAGACGTGCTATC
CGTGATGCCAAAACACCTGACAAGATGAAAAAGTCAAAATCTGTAAAGGAAGACAGCAACCTCACTCTTCAAGAGAAGAAAGAGAAGATC
CAGACAGGTTTAAAGAAGCTAACAGAGCTTGGAACCGTGGACCCAAAGAACAAATACCAGGAACTGATCAACGACATTGCCAGGGATATT
CGGAATCAGCGGAGGTACCGACAGAGGAGAAAGGCCGAACTAGTGAAACTGCAACAGACATACGCTGCTCTGAACTCTAAGGCCACCTTT
TATGGGGAGCAGGTGGATTACTATAAAAGCTATATCAAAACCTGCTTGGATAACTTAGCCAGCAAGGGCAAAGTCTCCAAAAAGCCTAGG
GAAATGAAAGGAAAGAAAAGCAAAAAGATTTCTCTGAAATATACAGCAGCAAGACTACATGAAAAAGGAGTTCTTCTGGAAATTGAGGAC
CTGCAAGTGAATCAGTTTAAAAATGTTATATTTGAAATCAGTCCAACAGAAGAAGTTGGAGACTTCGAAGTGAAAGCCAAATTCATGGGA
GTTCAAATGGAGACTTTTATGTTACATTATCAGGACCTGCTGCAGCTACAGTATGAAGGAGTTGCAGTCATGAAATTATTTGATAGAGCT
AAAGTAAATGTCAACCTCCTGATCTTCCTTCTCAACAAAAAGTTCTACGGGAAGTAATTGATCGTTTGCTGCCAGCCCAGAAGGATGAAG
GAAAGAAGCACCTCACAGCTCCTTTCTAGGTCCTTCTTTCCTCATTGGAAGCAAAGACCTAGCCAACAACAGCACCTCAATCTGATACAC
TCCCGATGCCACATTTTTAACTCCTCTCGCTCTGATGGGACATTTGTTACCCTTTTTTCATAGTGAAATTGTGTTTCAGGCTTAGTCTGA

>53009_53009_4_METAP1-IQGAP1_METAP1_chr4_99966461_ENST00000544031_IQGAP1_chr15_91030186_ENST00000560738_length(amino acids)=528AA_BP=212
MCTMHKDEKAKREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMR
LVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHG
DLNETFFVGEVDDGARKLVQTTYECLMQAIDAGESSGNLNDPNKEALAKTEVSLTLTNKFDVPGDENAEMDARTILLNTKRLIVDVIRFQ
PGETLTEILETPATSEQEAEHQRAMQRRAIRDAKTPDKMKKSKSVKEDSNLTLQEKKEKIQTGLKKLTELGTVDPKNKYQELINDIARDI
RNQRRYRQRRKAELVKLQQTYAALNSKATFYGEQVDYYKSYIKTCLDNLASKGKVSKKPREMKGKKSKKISLKYTAARLHEKGVLLEIED

--------------------------------------------------------------

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Fusion Gene PPI Analysis for METAP1-IQGAP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for METAP1-IQGAP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for METAP1-IQGAP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource