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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:AP3S2-CERS3 (FusionGDB2 ID:5301)

Fusion Gene Summary for AP3S2-CERS3

Fusion gene summary

Fusion gene information	Fusion gene name: AP3S2-CERS3
	Fusion gene ID: 5301
		Hgene	Tgene
	Gene symbol	AP3S2	CERS3
	Gene ID	10239	204219
	Gene name	adaptor related protein complex 3 subunit sigma 2	ceramide synthase 3
	Synonyms	AP3S3\|sigma3b	ARCI9\|LASS3
	Cytomap	15q26.1	15q26.3
	Type of gene	protein-coding	protein-coding
	Description	AP-3 complex subunit sigma-2AP-3 complex subunit sigma-3Badapter-related protein complex 3 subunit sigma-2adaptor complex sigma3Badaptor related protein complex 3 sigma 2 subunitclathrin-associated/assembly/adaptor protein, small 4, 22-kDsigma-3B-ad	ceramide synthase 3LAG1 homolog, ceramide synthase 3LAG1 longevity assurance homolog 3dihydroceramide synthase 3sphingosine N-acyltransferase CERS3
	Modification date	20200313	20200313
	UniProtAcc	.	Q8IU89
	Ensembl transtripts involved in fusion gene	ENST00000336418, ENST00000558011, ENST00000560940, ENST00000560771,	ENST00000560944, ENST00000284382, ENST00000394113, ENST00000538112,
Fusion gene scores	* DoF score	3 X 1 X 2=6	8 X 7 X 7=392
	# samples	3	11
	** MAII score	log2(3/6*10)=2.32192809488736	log2(11/392*10)=-1.83335013059055 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: AP3S2 [Title/Abstract] AND CERS3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	AP3S2(90414707)-CERS3(101024873), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CERS3	GO:0046513	ceramide biosynthetic process	17977534\|22038835

Fusion gene breakpoints across AP3S2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CERS3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-C8-A1HI-01A	AP3S2	chr15	90414707	-	CERS3	chr15	101024873	-

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Fusion Gene ORF analysis for AP3S2-CERS3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000336418	ENST00000560944	AP3S2	chr15	90414707	-	CERS3	chr15	101024873	-
5CDS-intron	ENST00000558011	ENST00000560944	AP3S2	chr15	90414707	-	CERS3	chr15	101024873	-
5CDS-intron	ENST00000560940	ENST00000560944	AP3S2	chr15	90414707	-	CERS3	chr15	101024873	-
In-frame	ENST00000336418	ENST00000284382	AP3S2	chr15	90414707	-	CERS3	chr15	101024873	-
In-frame	ENST00000336418	ENST00000394113	AP3S2	chr15	90414707	-	CERS3	chr15	101024873	-
In-frame	ENST00000336418	ENST00000538112	AP3S2	chr15	90414707	-	CERS3	chr15	101024873	-
In-frame	ENST00000558011	ENST00000284382	AP3S2	chr15	90414707	-	CERS3	chr15	101024873	-
In-frame	ENST00000558011	ENST00000394113	AP3S2	chr15	90414707	-	CERS3	chr15	101024873	-
In-frame	ENST00000558011	ENST00000538112	AP3S2	chr15	90414707	-	CERS3	chr15	101024873	-
In-frame	ENST00000560940	ENST00000284382	AP3S2	chr15	90414707	-	CERS3	chr15	101024873	-
In-frame	ENST00000560940	ENST00000394113	AP3S2	chr15	90414707	-	CERS3	chr15	101024873	-
In-frame	ENST00000560940	ENST00000538112	AP3S2	chr15	90414707	-	CERS3	chr15	101024873	-
intron-3CDS	ENST00000560771	ENST00000284382	AP3S2	chr15	90414707	-	CERS3	chr15	101024873	-
intron-3CDS	ENST00000560771	ENST00000394113	AP3S2	chr15	90414707	-	CERS3	chr15	101024873	-
intron-3CDS	ENST00000560771	ENST00000538112	AP3S2	chr15	90414707	-	CERS3	chr15	101024873	-
intron-intron	ENST00000560771	ENST00000560944	AP3S2	chr15	90414707	-	CERS3	chr15	101024873	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000336418	AP3S2	chr15	90414707	-	ENST00000284382	CERS3	chr15	101024873	-	3920	738	369	1601	410
ENST00000336418	AP3S2	chr15	90414707	-	ENST00000538112	CERS3	chr15	101024873	-	1804	738	369	1601	410
ENST00000336418	AP3S2	chr15	90414707	-	ENST00000394113	CERS3	chr15	101024873	-	1804	738	369	1601	410
ENST00000558011	AP3S2	chr15	90414707	-	ENST00000284382	CERS3	chr15	101024873	-	3608	426	21	1289	422
ENST00000558011	AP3S2	chr15	90414707	-	ENST00000538112	CERS3	chr15	101024873	-	1492	426	21	1289	422
ENST00000558011	AP3S2	chr15	90414707	-	ENST00000394113	CERS3	chr15	101024873	-	1492	426	21	1289	422
ENST00000560940	AP3S2	chr15	90414707	-	ENST00000284382	CERS3	chr15	101024873	-	3559	377	8	1240	410
ENST00000560940	AP3S2	chr15	90414707	-	ENST00000538112	CERS3	chr15	101024873	-	1443	377	8	1240	410
ENST00000560940	AP3S2	chr15	90414707	-	ENST00000394113	CERS3	chr15	101024873	-	1443	377	8	1240	410

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000336418	ENST00000284382	AP3S2	chr15	90414707	-	CERS3	chr15	101024873	-	0.002685812	0.99731416
ENST00000336418	ENST00000538112	AP3S2	chr15	90414707	-	CERS3	chr15	101024873	-	0.004644795	0.99535525
ENST00000336418	ENST00000394113	AP3S2	chr15	90414707	-	CERS3	chr15	101024873	-	0.004644795	0.99535525
ENST00000558011	ENST00000284382	AP3S2	chr15	90414707	-	CERS3	chr15	101024873	-	0.001874565	0.9981254
ENST00000558011	ENST00000538112	AP3S2	chr15	90414707	-	CERS3	chr15	101024873	-	0.002265393	0.99773455
ENST00000558011	ENST00000394113	AP3S2	chr15	90414707	-	CERS3	chr15	101024873	-	0.002265393	0.99773455
ENST00000560940	ENST00000284382	AP3S2	chr15	90414707	-	CERS3	chr15	101024873	-	0.001690084	0.99830997
ENST00000560940	ENST00000538112	AP3S2	chr15	90414707	-	CERS3	chr15	101024873	-	0.002034783	0.9979652
ENST00000560940	ENST00000394113	AP3S2	chr15	90414707	-	CERS3	chr15	101024873	-	0.002034783	0.9979652

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Fusion Genomic Features for AP3S2-CERS3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for AP3S2-CERS3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:90414707/chr15:101024873)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	CERS3 Q8IU89
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward very-long (C22:0-C24:0) and ultra long chain (more than C26:0) as acyl donor (PubMed:17977534, PubMed:22038835, PubMed:26887952). It is crucial for the synthesis of ultra long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal differentiation (PubMed:23754960). {ECO:0000269\|PubMed:17977534, ECO:0000269\|PubMed:22038835, ECO:0000269\|PubMed:23754960, ECO:0000269\|PubMed:26887952}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000284382

346_355

384.0

Compositional bias

Note=Poly-Glu

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000394113

346_355

384.0

Compositional bias

Note=Poly-Glu

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000538112

346_355

384.0

Compositional bias

Note=Poly-Glu

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000284382

130_331

384.0

Domain

TLC

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000394113

130_331

384.0

Domain

TLC

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000538112

130_331

384.0

Domain

TLC

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000284382

319_383

384.0

Topological domain

Cytoplasmic

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000394113

319_383

384.0

Topological domain

Cytoplasmic

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000538112

319_383

384.0

Topological domain

Cytoplasmic

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000284382

139_159

384.0

Transmembrane

Helical

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000284382

174_194

384.0

Transmembrane

Helical

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000284382

205_225

384.0

Transmembrane

Helical

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000284382

264_284

384.0

Transmembrane

Helical

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000284382

298_318

384.0

Transmembrane

Helical

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000394113

139_159

384.0

Transmembrane

Helical

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000394113

174_194

384.0

Transmembrane

Helical

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000394113

205_225

384.0

Transmembrane

Helical

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000394113

264_284

384.0

Transmembrane

Helical

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000394113

298_318

384.0

Transmembrane

Helical

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000538112

139_159

384.0

Transmembrane

Helical

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000538112

174_194

384.0

Transmembrane

Helical

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000538112

205_225

384.0

Transmembrane

Helical

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000538112

264_284

384.0

Transmembrane

Helical

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000538112

298_318

384.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000284382

66_127

384.0

Region

Homeobox-like

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000394113

66_127

384.0

Region

Homeobox-like

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000538112

66_127

384.0

Region

Homeobox-like

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000284382

32_52

384.0

Transmembrane

Helical

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000394113

32_52

384.0

Transmembrane

Helical

Tgene

CERS3

chr15:90414707

chr15:101024873

ENST00000538112

32_52

384.0

Transmembrane

Helical

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Fusion Gene Sequence for AP3S2-CERS3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>5301_5301_1_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000336418_CERS3_chr15_101024873_ENST00000284382_length(transcript)=3920nt_BP=738nt
ACGTTCTGCGAGCGCTAAGGGGATGGCGGGAGTGCATGATTTGGAGCGGGCGGTGAGAAAAGCAAGCTCCCGCCGCCTCTCCGTTTTGGC
AACCCGGCTGACGGTCGTTTCGGCTTCTGGGGCCAGCCGTCGGTCTGGGCGAGGGACATAGATCCGGATTCGCATCCTGACTGGCCAACC
AACGCTGGCCGAGGTGACCACTCTCCTCGGCATCCGCACCTGCCCTCCAAGGCGTCAGAGAGGCCGGACCCTTGGGTGCTAGGGCTCGTG
AGCGCCGGGGCCAAGTTTCCGAGTGCCGCTCTCAGCAGCGCACCAACCGGAAGTGATCGTGTTGTGGCGGAAGGAGGAGCTTTCTGGGAG
TAGCCGGTGCTGAGAGAACCGTGGCTGGCAAAGATGATTCAGGCGATTCTGGTTTTCAACAACCATGGGAAGCCACGGCTAGTCCGCTTC
TACCAGCGTTTCCCAGAAGAAATTCAACAGCAGATTGTTCGAGAGACTTTCCATCTAGTCCTCAAGCGGGATGACAACATCTGTAACTTC
TTGGAGGGTGGAAGTTTGATTGGTGGCTCTGACTACAAACTGATCTACCGGCACTATGCTACCCTCTACTTTGTATTTTGTGTGGATTCC
TCAGAGAGTGAACTTGGAATCTTGGACCTCATCCAGGTTTTTGTGGAAACTCTGGATAAGTGTTTCGAAAATGTGTGTGAATTGGATTTG
ATCTTCCATATGGATAAGACTGATATTTATGGACTGGCAAAGAAGTGTAACTTGACGGAGCGCCAGGTGGAAAGATGGTTTAGGAGTCGG
CGGAATCAAGAGAGGCCTTCCAGGCTGAAGAAATTCCAGGAAGCTTGCTGGAGATTTGCATTTTACTTAATGATCACTGTTGCTGGAATT
GCGTTTCTTTATGATAAACCTTGGCTATATGACTTATGGGAGGTTTGGAATGGCTATCCCAAACAGCCCCTGCTGCCATCCCAGTACTGG
TACTACATTTTAGAAATGAGTTTTTATTGGTCTCTGTTATTTAGACTTGGCTTTGATGTCAAGAGAAAGGATTTTCTAGCTCATATCATC
CACCACCTGGCTGCTATTAGTCTGATGAGCTTCTCTTGGTGTGCTAATTATATTCGCAGTGGGACCCTCGTGATGATTGTACACGATGTG
GCTGACATTTGGCTGGAGTCTGCTAAGATGTTTTCTTATGCTGGATGGACGCAGACCTGTAACACCCTGTTTTTCATCTTCTCCACCATA
TTTTTCATCAGCCGCCTCATTGTTTTTCCTTTCTGGATTTTATATTGCACGCTGATCTTGCCTATGTATCACCTCGAGCCTTTCTTTTCA
TACATCTTCCTCAACCTACAGCTCATGATCTTGCAGGTCCTTCACCTTTACTGGGGTTATTACATCTTGAAGATGCTCAACAGATGTATA
TTCATGAAGAGCATCCAGGATGTGAGGAGTGATGACGAGGATTATGAAGAGGAAGAGGAAGAGGAAGAAGAAGAGGCTACCAAAGGCAAA
GAGATGGATTGTTTAAAGAACGGCCTCAGGGCTGAGAGGCACCTCATTCCCAATGGCCAGCATGGCCATTAGCTGGAAGCCTACAGGACT
CCCATGGCACAGCATGCTGCAAGTACTGTTGGCAGCCTGGCTTCCAGGCCCCACACCGACCCCACATTCTGCCCTTCCCTCTTTCTCACC
ACCGCCTTCCCTCCCACCTAAGATGTGTTTACCAAAATGTTGTTAACTTGTGTTAAAATGTTAAATATAAGCATGCCCATGGATTTTTAC
TGCAGTTAGGACTCAGACTGGTCAAAGATTTCAAAGATTTCTCCACAGAACCGTCTCAGTTCTAATTGCACTCCCTCATGCATGTCACTT
TCTCAGGGGCTCGCTTTGTTATAGACCCTTTCGCCTCGCCACCTTGCCTGTCCTCAGGACGCTTTCACAGGTGCTAAGTGATCTCATTTT
TCCCAGGTGTGTTTGGCCACAAAGAGCAGCTTCTTTCTCAAAATGAGTTAGAAGTGGCAGTGGGACAGGAGCGGAAGGACCACACCAGGA
GACACTTCCATCCTGAAGCTTAGGTGCCTCATCTCCACAGGGCGGTGGCAGTCCCTGCCTGCCACCCCACAGGGTTACAGCAAGGATTAA
GTGAGATCACAGAAGTTTAAGTACACACTGTCAACCGTGGGGTCATCGTGAACCAACCCACTTTGCACTGTTTGGGAGACAGAAACCTGG
CTAAACATGGCACTGCAATGGGCCTGAACAAAAGGCAGAATCTTTAAAAATTCCTCTTAAATGACTCTGGAGATACCTGGAAATGAAAGT
GCCAAGAAAGGTGTTCCATTTTATTTGCTAACTATTTATGCATTAGCTCCCCAAGGGTCATTCTCAGATTCTCCTGGAATTCTTCTCCCT
CAGGACCCATGGTTCAAGGAAGGAAGCTTAGGCCCTGTTCCTTCCTGTCCTTTGCTGGTCTTTCCCTTTTTTCCTTTCTAGGAGGGAAGC
TTCTGTGCTGCTGCCCTGAGCCCTTCCTTCAGGCCAGCACAGTACCTGGGGACCTCCACGGGGGAATGGGATCCAGGCCAGGTTGCTTGC
TGAGCCTCATCACCCAGGAGGCCTGAGCCTCTGGGGAGGGCACGCATGTACACTGCCAGACCCAGGGGAGATCTTGGGAACAGAGGATGC
TACGTGATTTCCTCTGGCTTCCAACCCAATCAGCCTGCATCACAGTGAAACACAACACAAAAGGCCATAAAAGGCATACCCCTGAGAAAT
GTTTAAGGGCAGGTGCTAGAGTCAGTGCCAGCTCCCTGGGAGGAGGGATAGGGACGGGCAGATCAGTAGCCAGCTTGTCCTCACCCTCCG
GAAGGGAGCACCGGAGAAGACTTGCACACGTCCCTGCCTCCCTTGCGGCCTTGTCACCAGAGGGACACATCTCCTGGGCACAATGTGCAG
GGCTGACCTGGGAGACTTCTCAGGTGGCTGCTGGCTGAGGAGAGGCCAGGCCTTCCCAAGGAAGACCCTGAGTAAAATCTGCATCTGTCC
TCACCACCTGGCACAGTCTCTCATAACGGTCAGATTTTGTATGTTCATCCTATTTATTCAGGGGCTCGTACTAGAAAGCCACAGGAGAGG
TCGGCTTGTAGGGACTGGAAAATCAGCCCCAAGCAGAGCAGCTGCAGGGCCCCTGGAGCCGGAAGGACACTGCACAGAACAGACTGCGTT
ATTGTTATTTTTAAATAAAAATATACATTTGAAACCTTAAGGCTAAACAAAAATAAACAAAAAATCCTTTAGAATTCTTTCCACAACAAT
ATCTCTTTCTGAGAAATTGTTACAAACAAGGTCAGATTTTCTCTGTATAACATTTGCTTTTATGAGGACAATATCATATGCATTATATGC
ATAATATGATATTATAAATCAAAATGCCTGCACCCACTTTAGGGTATAGCTATTGACTTATTATTAATATTATATTATTATTATTTTGCT
GGAAGAAGGTCACACTAAGATATAATTTTTTATGTTTTCAGTTAACGGTATGCTTTCTTCTTTGCTTATTTGGTTTTTGTCTCTGTACCA
AATATCTTCTTGCTTAAGGTAGAAAAGTATTTGTTTACCTCTATCTCCAGTTTTTTTTCTTATTTGAATGTTGAAGGTAAAATTGATATA
CCAATTTTAACTATTTCTGATACAGCTGAAAGCACTAAACTACTTCATAAGAAGTAGATACTCATTTTTGTAACACTATTTAGGGCTTTT
GTGGTTAATTTTAAAGGAAACCACTCTTTCTACAGGAAACAAGGGCTCAGGATTCTTCAGATGACCTTATAAAAATGCAGTCCACAGTGC

>5301_5301_1_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000336418_CERS3_chr15_101024873_ENST00000284382_length(amino acids)=410AA_BP=123
MREPWLAKMIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSES
ELGILDLIQVFVETLDKCFENVCELDLIFHMDKTDIYGLAKKCNLTERQVERWFRSRRNQERPSRLKKFQEACWRFAFYLMITVAGIAFL
YDKPWLYDLWEVWNGYPKQPLLPSQYWYYILEMSFYWSLLFRLGFDVKRKDFLAHIIHHLAAISLMSFSWCANYIRSGTLVMIVHDVADI
WLESAKMFSYAGWTQTCNTLFFIFSTIFFISRLIVFPFWILYCTLILPMYHLEPFFSYIFLNLQLMILQVLHLYWGYYILKMLNRCIFMK

--------------------------------------------------------------
>5301_5301_2_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000336418_CERS3_chr15_101024873_ENST00000394113_length(transcript)=1804nt_BP=738nt
ACGTTCTGCGAGCGCTAAGGGGATGGCGGGAGTGCATGATTTGGAGCGGGCGGTGAGAAAAGCAAGCTCCCGCCGCCTCTCCGTTTTGGC
AACCCGGCTGACGGTCGTTTCGGCTTCTGGGGCCAGCCGTCGGTCTGGGCGAGGGACATAGATCCGGATTCGCATCCTGACTGGCCAACC
AACGCTGGCCGAGGTGACCACTCTCCTCGGCATCCGCACCTGCCCTCCAAGGCGTCAGAGAGGCCGGACCCTTGGGTGCTAGGGCTCGTG
AGCGCCGGGGCCAAGTTTCCGAGTGCCGCTCTCAGCAGCGCACCAACCGGAAGTGATCGTGTTGTGGCGGAAGGAGGAGCTTTCTGGGAG
TAGCCGGTGCTGAGAGAACCGTGGCTGGCAAAGATGATTCAGGCGATTCTGGTTTTCAACAACCATGGGAAGCCACGGCTAGTCCGCTTC
TACCAGCGTTTCCCAGAAGAAATTCAACAGCAGATTGTTCGAGAGACTTTCCATCTAGTCCTCAAGCGGGATGACAACATCTGTAACTTC
TTGGAGGGTGGAAGTTTGATTGGTGGCTCTGACTACAAACTGATCTACCGGCACTATGCTACCCTCTACTTTGTATTTTGTGTGGATTCC
TCAGAGAGTGAACTTGGAATCTTGGACCTCATCCAGGTTTTTGTGGAAACTCTGGATAAGTGTTTCGAAAATGTGTGTGAATTGGATTTG
ATCTTCCATATGGATAAGACTGATATTTATGGACTGGCAAAGAAGTGTAACTTGACGGAGCGCCAGGTGGAAAGATGGTTTAGGAGTCGG
CGGAATCAAGAGAGGCCTTCCAGGCTGAAGAAATTCCAGGAAGCTTGCTGGAGATTTGCATTTTACTTAATGATCACTGTTGCTGGAATT
GCGTTTCTTTATGATAAACCTTGGCTATATGACTTATGGGAGGTTTGGAATGGCTATCCCAAACAGCCCCTGCTGCCATCCCAGTACTGG
TACTACATTTTAGAAATGAGTTTTTATTGGTCTCTGTTATTTAGACTTGGCTTTGATGTCAAGAGAAAGGATTTTCTAGCTCATATCATC
CACCACCTGGCTGCTATTAGTCTGATGAGCTTCTCTTGGTGTGCTAATTATATTCGCAGTGGGACCCTCGTGATGATTGTACACGATGTG
GCTGACATTTGGCTGGAGTCTGCTAAGATGTTTTCTTATGCTGGATGGACGCAGACCTGTAACACCCTGTTTTTCATCTTCTCCACCATA
TTTTTCATCAGCCGCCTCATTGTTTTTCCTTTCTGGATTTTATATTGCACGCTGATCTTGCCTATGTATCACCTCGAGCCTTTCTTTTCA
TACATCTTCCTCAACCTACAGCTCATGATCTTGCAGGTCCTTCACCTTTACTGGGGTTATTACATCTTGAAGATGCTCAACAGATGTATA
TTCATGAAGAGCATCCAGGATGTGAGGAGTGATGACGAGGATTATGAAGAGGAAGAGGAAGAGGAAGAAGAAGAGGCTACCAAAGGCAAA
GAGATGGATTGTTTAAAGAACGGCCTCAGGGCTGAGAGGCACCTCATTCCCAATGGCCAGCATGGCCATTAGCTGGAAGCCTACAGGACT
CCCATGGCACAGCATGCTGCAAGTACTGTTGGCAGCCTGGCTTCCAGGCCCCACACCGACCCCACATTCTGCCCTTCCCTCTTTCTCACC
ACCGCCTTCCCTCCCACCTAAGATGTGTTTACCAAAATGTTGTTAACTTGTGTTAAAATGTTAAATATAAGCATGCCCATGGATTTTTAC

>5301_5301_2_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000336418_CERS3_chr15_101024873_ENST00000394113_length(amino acids)=410AA_BP=123
MREPWLAKMIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSES
ELGILDLIQVFVETLDKCFENVCELDLIFHMDKTDIYGLAKKCNLTERQVERWFRSRRNQERPSRLKKFQEACWRFAFYLMITVAGIAFL
YDKPWLYDLWEVWNGYPKQPLLPSQYWYYILEMSFYWSLLFRLGFDVKRKDFLAHIIHHLAAISLMSFSWCANYIRSGTLVMIVHDVADI
WLESAKMFSYAGWTQTCNTLFFIFSTIFFISRLIVFPFWILYCTLILPMYHLEPFFSYIFLNLQLMILQVLHLYWGYYILKMLNRCIFMK

--------------------------------------------------------------
>5301_5301_3_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000336418_CERS3_chr15_101024873_ENST00000538112_length(transcript)=1804nt_BP=738nt
ACGTTCTGCGAGCGCTAAGGGGATGGCGGGAGTGCATGATTTGGAGCGGGCGGTGAGAAAAGCAAGCTCCCGCCGCCTCTCCGTTTTGGC
AACCCGGCTGACGGTCGTTTCGGCTTCTGGGGCCAGCCGTCGGTCTGGGCGAGGGACATAGATCCGGATTCGCATCCTGACTGGCCAACC
AACGCTGGCCGAGGTGACCACTCTCCTCGGCATCCGCACCTGCCCTCCAAGGCGTCAGAGAGGCCGGACCCTTGGGTGCTAGGGCTCGTG
AGCGCCGGGGCCAAGTTTCCGAGTGCCGCTCTCAGCAGCGCACCAACCGGAAGTGATCGTGTTGTGGCGGAAGGAGGAGCTTTCTGGGAG
TAGCCGGTGCTGAGAGAACCGTGGCTGGCAAAGATGATTCAGGCGATTCTGGTTTTCAACAACCATGGGAAGCCACGGCTAGTCCGCTTC
TACCAGCGTTTCCCAGAAGAAATTCAACAGCAGATTGTTCGAGAGACTTTCCATCTAGTCCTCAAGCGGGATGACAACATCTGTAACTTC
TTGGAGGGTGGAAGTTTGATTGGTGGCTCTGACTACAAACTGATCTACCGGCACTATGCTACCCTCTACTTTGTATTTTGTGTGGATTCC
TCAGAGAGTGAACTTGGAATCTTGGACCTCATCCAGGTTTTTGTGGAAACTCTGGATAAGTGTTTCGAAAATGTGTGTGAATTGGATTTG
ATCTTCCATATGGATAAGACTGATATTTATGGACTGGCAAAGAAGTGTAACTTGACGGAGCGCCAGGTGGAAAGATGGTTTAGGAGTCGG
CGGAATCAAGAGAGGCCTTCCAGGCTGAAGAAATTCCAGGAAGCTTGCTGGAGATTTGCATTTTACTTAATGATCACTGTTGCTGGAATT
GCGTTTCTTTATGATAAACCTTGGCTATATGACTTATGGGAGGTTTGGAATGGCTATCCCAAACAGCCCCTGCTGCCATCCCAGTACTGG
TACTACATTTTAGAAATGAGTTTTTATTGGTCTCTGTTATTTAGACTTGGCTTTGATGTCAAGAGAAAGGATTTTCTAGCTCATATCATC
CACCACCTGGCTGCTATTAGTCTGATGAGCTTCTCTTGGTGTGCTAATTATATTCGCAGTGGGACCCTCGTGATGATTGTACACGATGTG
GCTGACATTTGGCTGGAGTCTGCTAAGATGTTTTCTTATGCTGGATGGACGCAGACCTGTAACACCCTGTTTTTCATCTTCTCCACCATA
TTTTTCATCAGCCGCCTCATTGTTTTTCCTTTCTGGATTTTATATTGCACGCTGATCTTGCCTATGTATCACCTCGAGCCTTTCTTTTCA
TACATCTTCCTCAACCTACAGCTCATGATCTTGCAGGTCCTTCACCTTTACTGGGGTTATTACATCTTGAAGATGCTCAACAGATGTATA
TTCATGAAGAGCATCCAGGATGTGAGGAGTGATGACGAGGATTATGAAGAGGAAGAGGAAGAGGAAGAAGAAGAGGCTACCAAAGGCAAA
GAGATGGATTGTTTAAAGAACGGCCTCAGGGCTGAGAGGCACCTCATTCCCAATGGCCAGCATGGCCATTAGCTGGAAGCCTACAGGACT
CCCATGGCACAGCATGCTGCAAGTACTGTTGGCAGCCTGGCTTCCAGGCCCCACACCGACCCCACATTCTGCCCTTCCCTCTTTCTCACC
ACCGCCTTCCCTCCCACCTAAGATGTGTTTACCAAAATGTTGTTAACTTGTGTTAAAATGTTAAATATAAGCATGCCCATGGATTTTTAC

>5301_5301_3_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000336418_CERS3_chr15_101024873_ENST00000538112_length(amino acids)=410AA_BP=123
MREPWLAKMIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSES
ELGILDLIQVFVETLDKCFENVCELDLIFHMDKTDIYGLAKKCNLTERQVERWFRSRRNQERPSRLKKFQEACWRFAFYLMITVAGIAFL
YDKPWLYDLWEVWNGYPKQPLLPSQYWYYILEMSFYWSLLFRLGFDVKRKDFLAHIIHHLAAISLMSFSWCANYIRSGTLVMIVHDVADI
WLESAKMFSYAGWTQTCNTLFFIFSTIFFISRLIVFPFWILYCTLILPMYHLEPFFSYIFLNLQLMILQVLHLYWGYYILKMLNRCIFMK

--------------------------------------------------------------
>5301_5301_4_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000558011_CERS3_chr15_101024873_ENST00000284382_length(transcript)=3608nt_BP=426nt
GCTTTCTGGGAGTAGCCGGTGCTGAGAGAACCGTGGCTGGCAAAGATGATTCAGGCGATTCTGGTTTTCAACAACCATGGGAAGCCACGG
CTAGTCCGCTTCTACCAGCGTTTCCCAGAAGAAATTCAACAGCAGATTGTTCGAGAGACTTTCCATCTAGTCCTCAAGCGGGATGACAAC
ATCTGTAACTTCTTGGAGGGTGGAAGTTTGATTGGTGGCTCTGACTACAAACTGATCTACCGGCACTATGCTACCCTCTACTTTGTATTT
TGTGTGGATTCCTCAGAGAGTGAACTTGGAATCTTGGACCTCATCCAGGTACATCTGGAAGTTGTTTTCTTCATAGCTCCCAAGGTTTTT
GTGGAAACTCTGGATAAGTGTTTCGAAAATGTGTGTGAATTGGATTTGATCTTCCATATGGATAAGACTGATATTTATGGACTGGCAAAG
AAGTGTAACTTGACGGAGCGCCAGGTGGAAAGATGGTTTAGGAGTCGGCGGAATCAAGAGAGGCCTTCCAGGCTGAAGAAATTCCAGGAA
GCTTGCTGGAGATTTGCATTTTACTTAATGATCACTGTTGCTGGAATTGCGTTTCTTTATGATAAACCTTGGCTATATGACTTATGGGAG
GTTTGGAATGGCTATCCCAAACAGCCCCTGCTGCCATCCCAGTACTGGTACTACATTTTAGAAATGAGTTTTTATTGGTCTCTGTTATTT
AGACTTGGCTTTGATGTCAAGAGAAAGGATTTTCTAGCTCATATCATCCACCACCTGGCTGCTATTAGTCTGATGAGCTTCTCTTGGTGT
GCTAATTATATTCGCAGTGGGACCCTCGTGATGATTGTACACGATGTGGCTGACATTTGGCTGGAGTCTGCTAAGATGTTTTCTTATGCT
GGATGGACGCAGACCTGTAACACCCTGTTTTTCATCTTCTCCACCATATTTTTCATCAGCCGCCTCATTGTTTTTCCTTTCTGGATTTTA
TATTGCACGCTGATCTTGCCTATGTATCACCTCGAGCCTTTCTTTTCATACATCTTCCTCAACCTACAGCTCATGATCTTGCAGGTCCTT
CACCTTTACTGGGGTTATTACATCTTGAAGATGCTCAACAGATGTATATTCATGAAGAGCATCCAGGATGTGAGGAGTGATGACGAGGAT
TATGAAGAGGAAGAGGAAGAGGAAGAAGAAGAGGCTACCAAAGGCAAAGAGATGGATTGTTTAAAGAACGGCCTCAGGGCTGAGAGGCAC
CTCATTCCCAATGGCCAGCATGGCCATTAGCTGGAAGCCTACAGGACTCCCATGGCACAGCATGCTGCAAGTACTGTTGGCAGCCTGGCT
TCCAGGCCCCACACCGACCCCACATTCTGCCCTTCCCTCTTTCTCACCACCGCCTTCCCTCCCACCTAAGATGTGTTTACCAAAATGTTG
TTAACTTGTGTTAAAATGTTAAATATAAGCATGCCCATGGATTTTTACTGCAGTTAGGACTCAGACTGGTCAAAGATTTCAAAGATTTCT
CCACAGAACCGTCTCAGTTCTAATTGCACTCCCTCATGCATGTCACTTTCTCAGGGGCTCGCTTTGTTATAGACCCTTTCGCCTCGCCAC
CTTGCCTGTCCTCAGGACGCTTTCACAGGTGCTAAGTGATCTCATTTTTCCCAGGTGTGTTTGGCCACAAAGAGCAGCTTCTTTCTCAAA
ATGAGTTAGAAGTGGCAGTGGGACAGGAGCGGAAGGACCACACCAGGAGACACTTCCATCCTGAAGCTTAGGTGCCTCATCTCCACAGGG
CGGTGGCAGTCCCTGCCTGCCACCCCACAGGGTTACAGCAAGGATTAAGTGAGATCACAGAAGTTTAAGTACACACTGTCAACCGTGGGG
TCATCGTGAACCAACCCACTTTGCACTGTTTGGGAGACAGAAACCTGGCTAAACATGGCACTGCAATGGGCCTGAACAAAAGGCAGAATC
TTTAAAAATTCCTCTTAAATGACTCTGGAGATACCTGGAAATGAAAGTGCCAAGAAAGGTGTTCCATTTTATTTGCTAACTATTTATGCA
TTAGCTCCCCAAGGGTCATTCTCAGATTCTCCTGGAATTCTTCTCCCTCAGGACCCATGGTTCAAGGAAGGAAGCTTAGGCCCTGTTCCT
TCCTGTCCTTTGCTGGTCTTTCCCTTTTTTCCTTTCTAGGAGGGAAGCTTCTGTGCTGCTGCCCTGAGCCCTTCCTTCAGGCCAGCACAG
TACCTGGGGACCTCCACGGGGGAATGGGATCCAGGCCAGGTTGCTTGCTGAGCCTCATCACCCAGGAGGCCTGAGCCTCTGGGGAGGGCA
CGCATGTACACTGCCAGACCCAGGGGAGATCTTGGGAACAGAGGATGCTACGTGATTTCCTCTGGCTTCCAACCCAATCAGCCTGCATCA
CAGTGAAACACAACACAAAAGGCCATAAAAGGCATACCCCTGAGAAATGTTTAAGGGCAGGTGCTAGAGTCAGTGCCAGCTCCCTGGGAG
GAGGGATAGGGACGGGCAGATCAGTAGCCAGCTTGTCCTCACCCTCCGGAAGGGAGCACCGGAGAAGACTTGCACACGTCCCTGCCTCCC
TTGCGGCCTTGTCACCAGAGGGACACATCTCCTGGGCACAATGTGCAGGGCTGACCTGGGAGACTTCTCAGGTGGCTGCTGGCTGAGGAG
AGGCCAGGCCTTCCCAAGGAAGACCCTGAGTAAAATCTGCATCTGTCCTCACCACCTGGCACAGTCTCTCATAACGGTCAGATTTTGTAT
GTTCATCCTATTTATTCAGGGGCTCGTACTAGAAAGCCACAGGAGAGGTCGGCTTGTAGGGACTGGAAAATCAGCCCCAAGCAGAGCAGC
TGCAGGGCCCCTGGAGCCGGAAGGACACTGCACAGAACAGACTGCGTTATTGTTATTTTTAAATAAAAATATACATTTGAAACCTTAAGG
CTAAACAAAAATAAACAAAAAATCCTTTAGAATTCTTTCCACAACAATATCTCTTTCTGAGAAATTGTTACAAACAAGGTCAGATTTTCT
CTGTATAACATTTGCTTTTATGAGGACAATATCATATGCATTATATGCATAATATGATATTATAAATCAAAATGCCTGCACCCACTTTAG
GGTATAGCTATTGACTTATTATTAATATTATATTATTATTATTTTGCTGGAAGAAGGTCACACTAAGATATAATTTTTTATGTTTTCAGT
TAACGGTATGCTTTCTTCTTTGCTTATTTGGTTTTTGTCTCTGTACCAAATATCTTCTTGCTTAAGGTAGAAAAGTATTTGTTTACCTCT
ATCTCCAGTTTTTTTTCTTATTTGAATGTTGAAGGTAAAATTGATATACCAATTTTAACTATTTCTGATACAGCTGAAAGCACTAAACTA
CTTCATAAGAAGTAGATACTCATTTTTGTAACACTATTTAGGGCTTTTGTGGTTAATTTTAAAGGAAACCACTCTTTCTACAGGAAACAA
GGGCTCAGGATTCTTCAGATGACCTTATAAAAATGCAGTCCACAGTGCTATCAATATTGTAACAGTAATGACTACAATAAAGCCAAAAGT

>5301_5301_4_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000558011_CERS3_chr15_101024873_ENST00000284382_length(amino acids)=422AA_BP=135
MREPWLAKMIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSES
ELGILDLIQVHLEVVFFIAPKVFVETLDKCFENVCELDLIFHMDKTDIYGLAKKCNLTERQVERWFRSRRNQERPSRLKKFQEACWRFAF
YLMITVAGIAFLYDKPWLYDLWEVWNGYPKQPLLPSQYWYYILEMSFYWSLLFRLGFDVKRKDFLAHIIHHLAAISLMSFSWCANYIRSG
TLVMIVHDVADIWLESAKMFSYAGWTQTCNTLFFIFSTIFFISRLIVFPFWILYCTLILPMYHLEPFFSYIFLNLQLMILQVLHLYWGYY

--------------------------------------------------------------
>5301_5301_5_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000558011_CERS3_chr15_101024873_ENST00000394113_length(transcript)=1492nt_BP=426nt
GCTTTCTGGGAGTAGCCGGTGCTGAGAGAACCGTGGCTGGCAAAGATGATTCAGGCGATTCTGGTTTTCAACAACCATGGGAAGCCACGG
CTAGTCCGCTTCTACCAGCGTTTCCCAGAAGAAATTCAACAGCAGATTGTTCGAGAGACTTTCCATCTAGTCCTCAAGCGGGATGACAAC
ATCTGTAACTTCTTGGAGGGTGGAAGTTTGATTGGTGGCTCTGACTACAAACTGATCTACCGGCACTATGCTACCCTCTACTTTGTATTT
TGTGTGGATTCCTCAGAGAGTGAACTTGGAATCTTGGACCTCATCCAGGTACATCTGGAAGTTGTTTTCTTCATAGCTCCCAAGGTTTTT
GTGGAAACTCTGGATAAGTGTTTCGAAAATGTGTGTGAATTGGATTTGATCTTCCATATGGATAAGACTGATATTTATGGACTGGCAAAG
AAGTGTAACTTGACGGAGCGCCAGGTGGAAAGATGGTTTAGGAGTCGGCGGAATCAAGAGAGGCCTTCCAGGCTGAAGAAATTCCAGGAA
GCTTGCTGGAGATTTGCATTTTACTTAATGATCACTGTTGCTGGAATTGCGTTTCTTTATGATAAACCTTGGCTATATGACTTATGGGAG
GTTTGGAATGGCTATCCCAAACAGCCCCTGCTGCCATCCCAGTACTGGTACTACATTTTAGAAATGAGTTTTTATTGGTCTCTGTTATTT
AGACTTGGCTTTGATGTCAAGAGAAAGGATTTTCTAGCTCATATCATCCACCACCTGGCTGCTATTAGTCTGATGAGCTTCTCTTGGTGT
GCTAATTATATTCGCAGTGGGACCCTCGTGATGATTGTACACGATGTGGCTGACATTTGGCTGGAGTCTGCTAAGATGTTTTCTTATGCT
GGATGGACGCAGACCTGTAACACCCTGTTTTTCATCTTCTCCACCATATTTTTCATCAGCCGCCTCATTGTTTTTCCTTTCTGGATTTTA
TATTGCACGCTGATCTTGCCTATGTATCACCTCGAGCCTTTCTTTTCATACATCTTCCTCAACCTACAGCTCATGATCTTGCAGGTCCTT
CACCTTTACTGGGGTTATTACATCTTGAAGATGCTCAACAGATGTATATTCATGAAGAGCATCCAGGATGTGAGGAGTGATGACGAGGAT
TATGAAGAGGAAGAGGAAGAGGAAGAAGAAGAGGCTACCAAAGGCAAAGAGATGGATTGTTTAAAGAACGGCCTCAGGGCTGAGAGGCAC
CTCATTCCCAATGGCCAGCATGGCCATTAGCTGGAAGCCTACAGGACTCCCATGGCACAGCATGCTGCAAGTACTGTTGGCAGCCTGGCT
TCCAGGCCCCACACCGACCCCACATTCTGCCCTTCCCTCTTTCTCACCACCGCCTTCCCTCCCACCTAAGATGTGTTTACCAAAATGTTG

>5301_5301_5_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000558011_CERS3_chr15_101024873_ENST00000394113_length(amino acids)=422AA_BP=135
MREPWLAKMIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSES
ELGILDLIQVHLEVVFFIAPKVFVETLDKCFENVCELDLIFHMDKTDIYGLAKKCNLTERQVERWFRSRRNQERPSRLKKFQEACWRFAF
YLMITVAGIAFLYDKPWLYDLWEVWNGYPKQPLLPSQYWYYILEMSFYWSLLFRLGFDVKRKDFLAHIIHHLAAISLMSFSWCANYIRSG
TLVMIVHDVADIWLESAKMFSYAGWTQTCNTLFFIFSTIFFISRLIVFPFWILYCTLILPMYHLEPFFSYIFLNLQLMILQVLHLYWGYY

--------------------------------------------------------------
>5301_5301_6_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000558011_CERS3_chr15_101024873_ENST00000538112_length(transcript)=1492nt_BP=426nt
GCTTTCTGGGAGTAGCCGGTGCTGAGAGAACCGTGGCTGGCAAAGATGATTCAGGCGATTCTGGTTTTCAACAACCATGGGAAGCCACGG
CTAGTCCGCTTCTACCAGCGTTTCCCAGAAGAAATTCAACAGCAGATTGTTCGAGAGACTTTCCATCTAGTCCTCAAGCGGGATGACAAC
ATCTGTAACTTCTTGGAGGGTGGAAGTTTGATTGGTGGCTCTGACTACAAACTGATCTACCGGCACTATGCTACCCTCTACTTTGTATTT
TGTGTGGATTCCTCAGAGAGTGAACTTGGAATCTTGGACCTCATCCAGGTACATCTGGAAGTTGTTTTCTTCATAGCTCCCAAGGTTTTT
GTGGAAACTCTGGATAAGTGTTTCGAAAATGTGTGTGAATTGGATTTGATCTTCCATATGGATAAGACTGATATTTATGGACTGGCAAAG
AAGTGTAACTTGACGGAGCGCCAGGTGGAAAGATGGTTTAGGAGTCGGCGGAATCAAGAGAGGCCTTCCAGGCTGAAGAAATTCCAGGAA
GCTTGCTGGAGATTTGCATTTTACTTAATGATCACTGTTGCTGGAATTGCGTTTCTTTATGATAAACCTTGGCTATATGACTTATGGGAG
GTTTGGAATGGCTATCCCAAACAGCCCCTGCTGCCATCCCAGTACTGGTACTACATTTTAGAAATGAGTTTTTATTGGTCTCTGTTATTT
AGACTTGGCTTTGATGTCAAGAGAAAGGATTTTCTAGCTCATATCATCCACCACCTGGCTGCTATTAGTCTGATGAGCTTCTCTTGGTGT
GCTAATTATATTCGCAGTGGGACCCTCGTGATGATTGTACACGATGTGGCTGACATTTGGCTGGAGTCTGCTAAGATGTTTTCTTATGCT
GGATGGACGCAGACCTGTAACACCCTGTTTTTCATCTTCTCCACCATATTTTTCATCAGCCGCCTCATTGTTTTTCCTTTCTGGATTTTA
TATTGCACGCTGATCTTGCCTATGTATCACCTCGAGCCTTTCTTTTCATACATCTTCCTCAACCTACAGCTCATGATCTTGCAGGTCCTT
CACCTTTACTGGGGTTATTACATCTTGAAGATGCTCAACAGATGTATATTCATGAAGAGCATCCAGGATGTGAGGAGTGATGACGAGGAT
TATGAAGAGGAAGAGGAAGAGGAAGAAGAAGAGGCTACCAAAGGCAAAGAGATGGATTGTTTAAAGAACGGCCTCAGGGCTGAGAGGCAC
CTCATTCCCAATGGCCAGCATGGCCATTAGCTGGAAGCCTACAGGACTCCCATGGCACAGCATGCTGCAAGTACTGTTGGCAGCCTGGCT
TCCAGGCCCCACACCGACCCCACATTCTGCCCTTCCCTCTTTCTCACCACCGCCTTCCCTCCCACCTAAGATGTGTTTACCAAAATGTTG

>5301_5301_6_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000558011_CERS3_chr15_101024873_ENST00000538112_length(amino acids)=422AA_BP=135
MREPWLAKMIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSES
ELGILDLIQVHLEVVFFIAPKVFVETLDKCFENVCELDLIFHMDKTDIYGLAKKCNLTERQVERWFRSRRNQERPSRLKKFQEACWRFAF
YLMITVAGIAFLYDKPWLYDLWEVWNGYPKQPLLPSQYWYYILEMSFYWSLLFRLGFDVKRKDFLAHIIHHLAAISLMSFSWCANYIRSG
TLVMIVHDVADIWLESAKMFSYAGWTQTCNTLFFIFSTIFFISRLIVFPFWILYCTLILPMYHLEPFFSYIFLNLQLMILQVLHLYWGYY

--------------------------------------------------------------
>5301_5301_7_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000560940_CERS3_chr15_101024873_ENST00000284382_length(transcript)=3559nt_BP=377nt
AGCCGGTGCTGAGAGAACCGTGGCTGGCAAAGATGATTCAGGCGATTCTGGTTTTCAACAACCATGGGAAGCCACGGCTAGTCCGCTTCT
ACCAGCGTTTCCCAGAAGAAATTCAACAGCAGATTGTTCGAGAGACTTTCCATCTAGTCCTCAAGCGGGATGACAACATCTGTAACTTCT
TGGAGGGTGGAAGTTTGATTGGTGGCTCTGACTACAAACTGATCTACCGGCACTATGCTACCCTCTACTTTGTATTTTGTGTGGATTCCT
CAGAGAGTGAACTTGGAATCTTGGACCTCATCCAGGTTTTTGTGGAAACTCTGGATAAGTGTTTCGAAAATGTGTGTGAATTGGATTTGA
TCTTCCATATGGATAAGACTGATATTTATGGACTGGCAAAGAAGTGTAACTTGACGGAGCGCCAGGTGGAAAGATGGTTTAGGAGTCGGC
GGAATCAAGAGAGGCCTTCCAGGCTGAAGAAATTCCAGGAAGCTTGCTGGAGATTTGCATTTTACTTAATGATCACTGTTGCTGGAATTG
CGTTTCTTTATGATAAACCTTGGCTATATGACTTATGGGAGGTTTGGAATGGCTATCCCAAACAGCCCCTGCTGCCATCCCAGTACTGGT
ACTACATTTTAGAAATGAGTTTTTATTGGTCTCTGTTATTTAGACTTGGCTTTGATGTCAAGAGAAAGGATTTTCTAGCTCATATCATCC
ACCACCTGGCTGCTATTAGTCTGATGAGCTTCTCTTGGTGTGCTAATTATATTCGCAGTGGGACCCTCGTGATGATTGTACACGATGTGG
CTGACATTTGGCTGGAGTCTGCTAAGATGTTTTCTTATGCTGGATGGACGCAGACCTGTAACACCCTGTTTTTCATCTTCTCCACCATAT
TTTTCATCAGCCGCCTCATTGTTTTTCCTTTCTGGATTTTATATTGCACGCTGATCTTGCCTATGTATCACCTCGAGCCTTTCTTTTCAT
ACATCTTCCTCAACCTACAGCTCATGATCTTGCAGGTCCTTCACCTTTACTGGGGTTATTACATCTTGAAGATGCTCAACAGATGTATAT
TCATGAAGAGCATCCAGGATGTGAGGAGTGATGACGAGGATTATGAAGAGGAAGAGGAAGAGGAAGAAGAAGAGGCTACCAAAGGCAAAG
AGATGGATTGTTTAAAGAACGGCCTCAGGGCTGAGAGGCACCTCATTCCCAATGGCCAGCATGGCCATTAGCTGGAAGCCTACAGGACTC
CCATGGCACAGCATGCTGCAAGTACTGTTGGCAGCCTGGCTTCCAGGCCCCACACCGACCCCACATTCTGCCCTTCCCTCTTTCTCACCA
CCGCCTTCCCTCCCACCTAAGATGTGTTTACCAAAATGTTGTTAACTTGTGTTAAAATGTTAAATATAAGCATGCCCATGGATTTTTACT
GCAGTTAGGACTCAGACTGGTCAAAGATTTCAAAGATTTCTCCACAGAACCGTCTCAGTTCTAATTGCACTCCCTCATGCATGTCACTTT
CTCAGGGGCTCGCTTTGTTATAGACCCTTTCGCCTCGCCACCTTGCCTGTCCTCAGGACGCTTTCACAGGTGCTAAGTGATCTCATTTTT
CCCAGGTGTGTTTGGCCACAAAGAGCAGCTTCTTTCTCAAAATGAGTTAGAAGTGGCAGTGGGACAGGAGCGGAAGGACCACACCAGGAG
ACACTTCCATCCTGAAGCTTAGGTGCCTCATCTCCACAGGGCGGTGGCAGTCCCTGCCTGCCACCCCACAGGGTTACAGCAAGGATTAAG
TGAGATCACAGAAGTTTAAGTACACACTGTCAACCGTGGGGTCATCGTGAACCAACCCACTTTGCACTGTTTGGGAGACAGAAACCTGGC
TAAACATGGCACTGCAATGGGCCTGAACAAAAGGCAGAATCTTTAAAAATTCCTCTTAAATGACTCTGGAGATACCTGGAAATGAAAGTG
CCAAGAAAGGTGTTCCATTTTATTTGCTAACTATTTATGCATTAGCTCCCCAAGGGTCATTCTCAGATTCTCCTGGAATTCTTCTCCCTC
AGGACCCATGGTTCAAGGAAGGAAGCTTAGGCCCTGTTCCTTCCTGTCCTTTGCTGGTCTTTCCCTTTTTTCCTTTCTAGGAGGGAAGCT
TCTGTGCTGCTGCCCTGAGCCCTTCCTTCAGGCCAGCACAGTACCTGGGGACCTCCACGGGGGAATGGGATCCAGGCCAGGTTGCTTGCT
GAGCCTCATCACCCAGGAGGCCTGAGCCTCTGGGGAGGGCACGCATGTACACTGCCAGACCCAGGGGAGATCTTGGGAACAGAGGATGCT
ACGTGATTTCCTCTGGCTTCCAACCCAATCAGCCTGCATCACAGTGAAACACAACACAAAAGGCCATAAAAGGCATACCCCTGAGAAATG
TTTAAGGGCAGGTGCTAGAGTCAGTGCCAGCTCCCTGGGAGGAGGGATAGGGACGGGCAGATCAGTAGCCAGCTTGTCCTCACCCTCCGG
AAGGGAGCACCGGAGAAGACTTGCACACGTCCCTGCCTCCCTTGCGGCCTTGTCACCAGAGGGACACATCTCCTGGGCACAATGTGCAGG
GCTGACCTGGGAGACTTCTCAGGTGGCTGCTGGCTGAGGAGAGGCCAGGCCTTCCCAAGGAAGACCCTGAGTAAAATCTGCATCTGTCCT
CACCACCTGGCACAGTCTCTCATAACGGTCAGATTTTGTATGTTCATCCTATTTATTCAGGGGCTCGTACTAGAAAGCCACAGGAGAGGT
CGGCTTGTAGGGACTGGAAAATCAGCCCCAAGCAGAGCAGCTGCAGGGCCCCTGGAGCCGGAAGGACACTGCACAGAACAGACTGCGTTA
TTGTTATTTTTAAATAAAAATATACATTTGAAACCTTAAGGCTAAACAAAAATAAACAAAAAATCCTTTAGAATTCTTTCCACAACAATA
TCTCTTTCTGAGAAATTGTTACAAACAAGGTCAGATTTTCTCTGTATAACATTTGCTTTTATGAGGACAATATCATATGCATTATATGCA
TAATATGATATTATAAATCAAAATGCCTGCACCCACTTTAGGGTATAGCTATTGACTTATTATTAATATTATATTATTATTATTTTGCTG
GAAGAAGGTCACACTAAGATATAATTTTTTATGTTTTCAGTTAACGGTATGCTTTCTTCTTTGCTTATTTGGTTTTTGTCTCTGTACCAA
ATATCTTCTTGCTTAAGGTAGAAAAGTATTTGTTTACCTCTATCTCCAGTTTTTTTTCTTATTTGAATGTTGAAGGTAAAATTGATATAC
CAATTTTAACTATTTCTGATACAGCTGAAAGCACTAAACTACTTCATAAGAAGTAGATACTCATTTTTGTAACACTATTTAGGGCTTTTG
TGGTTAATTTTAAAGGAAACCACTCTTTCTACAGGAAACAAGGGCTCAGGATTCTTCAGATGACCTTATAAAAATGCAGTCCACAGTGCT

>5301_5301_7_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000560940_CERS3_chr15_101024873_ENST00000284382_length(amino acids)=410AA_BP=123
MREPWLAKMIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSES
ELGILDLIQVFVETLDKCFENVCELDLIFHMDKTDIYGLAKKCNLTERQVERWFRSRRNQERPSRLKKFQEACWRFAFYLMITVAGIAFL
YDKPWLYDLWEVWNGYPKQPLLPSQYWYYILEMSFYWSLLFRLGFDVKRKDFLAHIIHHLAAISLMSFSWCANYIRSGTLVMIVHDVADI
WLESAKMFSYAGWTQTCNTLFFIFSTIFFISRLIVFPFWILYCTLILPMYHLEPFFSYIFLNLQLMILQVLHLYWGYYILKMLNRCIFMK

--------------------------------------------------------------
>5301_5301_8_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000560940_CERS3_chr15_101024873_ENST00000394113_length(transcript)=1443nt_BP=377nt
AGCCGGTGCTGAGAGAACCGTGGCTGGCAAAGATGATTCAGGCGATTCTGGTTTTCAACAACCATGGGAAGCCACGGCTAGTCCGCTTCT
ACCAGCGTTTCCCAGAAGAAATTCAACAGCAGATTGTTCGAGAGACTTTCCATCTAGTCCTCAAGCGGGATGACAACATCTGTAACTTCT
TGGAGGGTGGAAGTTTGATTGGTGGCTCTGACTACAAACTGATCTACCGGCACTATGCTACCCTCTACTTTGTATTTTGTGTGGATTCCT
CAGAGAGTGAACTTGGAATCTTGGACCTCATCCAGGTTTTTGTGGAAACTCTGGATAAGTGTTTCGAAAATGTGTGTGAATTGGATTTGA
TCTTCCATATGGATAAGACTGATATTTATGGACTGGCAAAGAAGTGTAACTTGACGGAGCGCCAGGTGGAAAGATGGTTTAGGAGTCGGC
GGAATCAAGAGAGGCCTTCCAGGCTGAAGAAATTCCAGGAAGCTTGCTGGAGATTTGCATTTTACTTAATGATCACTGTTGCTGGAATTG
CGTTTCTTTATGATAAACCTTGGCTATATGACTTATGGGAGGTTTGGAATGGCTATCCCAAACAGCCCCTGCTGCCATCCCAGTACTGGT
ACTACATTTTAGAAATGAGTTTTTATTGGTCTCTGTTATTTAGACTTGGCTTTGATGTCAAGAGAAAGGATTTTCTAGCTCATATCATCC
ACCACCTGGCTGCTATTAGTCTGATGAGCTTCTCTTGGTGTGCTAATTATATTCGCAGTGGGACCCTCGTGATGATTGTACACGATGTGG
CTGACATTTGGCTGGAGTCTGCTAAGATGTTTTCTTATGCTGGATGGACGCAGACCTGTAACACCCTGTTTTTCATCTTCTCCACCATAT
TTTTCATCAGCCGCCTCATTGTTTTTCCTTTCTGGATTTTATATTGCACGCTGATCTTGCCTATGTATCACCTCGAGCCTTTCTTTTCAT
ACATCTTCCTCAACCTACAGCTCATGATCTTGCAGGTCCTTCACCTTTACTGGGGTTATTACATCTTGAAGATGCTCAACAGATGTATAT
TCATGAAGAGCATCCAGGATGTGAGGAGTGATGACGAGGATTATGAAGAGGAAGAGGAAGAGGAAGAAGAAGAGGCTACCAAAGGCAAAG
AGATGGATTGTTTAAAGAACGGCCTCAGGGCTGAGAGGCACCTCATTCCCAATGGCCAGCATGGCCATTAGCTGGAAGCCTACAGGACTC
CCATGGCACAGCATGCTGCAAGTACTGTTGGCAGCCTGGCTTCCAGGCCCCACACCGACCCCACATTCTGCCCTTCCCTCTTTCTCACCA
CCGCCTTCCCTCCCACCTAAGATGTGTTTACCAAAATGTTGTTAACTTGTGTTAAAATGTTAAATATAAGCATGCCCATGGATTTTTACT

>5301_5301_8_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000560940_CERS3_chr15_101024873_ENST00000394113_length(amino acids)=410AA_BP=123
MREPWLAKMIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSES
ELGILDLIQVFVETLDKCFENVCELDLIFHMDKTDIYGLAKKCNLTERQVERWFRSRRNQERPSRLKKFQEACWRFAFYLMITVAGIAFL
YDKPWLYDLWEVWNGYPKQPLLPSQYWYYILEMSFYWSLLFRLGFDVKRKDFLAHIIHHLAAISLMSFSWCANYIRSGTLVMIVHDVADI
WLESAKMFSYAGWTQTCNTLFFIFSTIFFISRLIVFPFWILYCTLILPMYHLEPFFSYIFLNLQLMILQVLHLYWGYYILKMLNRCIFMK

--------------------------------------------------------------
>5301_5301_9_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000560940_CERS3_chr15_101024873_ENST00000538112_length(transcript)=1443nt_BP=377nt
AGCCGGTGCTGAGAGAACCGTGGCTGGCAAAGATGATTCAGGCGATTCTGGTTTTCAACAACCATGGGAAGCCACGGCTAGTCCGCTTCT
ACCAGCGTTTCCCAGAAGAAATTCAACAGCAGATTGTTCGAGAGACTTTCCATCTAGTCCTCAAGCGGGATGACAACATCTGTAACTTCT
TGGAGGGTGGAAGTTTGATTGGTGGCTCTGACTACAAACTGATCTACCGGCACTATGCTACCCTCTACTTTGTATTTTGTGTGGATTCCT
CAGAGAGTGAACTTGGAATCTTGGACCTCATCCAGGTTTTTGTGGAAACTCTGGATAAGTGTTTCGAAAATGTGTGTGAATTGGATTTGA
TCTTCCATATGGATAAGACTGATATTTATGGACTGGCAAAGAAGTGTAACTTGACGGAGCGCCAGGTGGAAAGATGGTTTAGGAGTCGGC
GGAATCAAGAGAGGCCTTCCAGGCTGAAGAAATTCCAGGAAGCTTGCTGGAGATTTGCATTTTACTTAATGATCACTGTTGCTGGAATTG
CGTTTCTTTATGATAAACCTTGGCTATATGACTTATGGGAGGTTTGGAATGGCTATCCCAAACAGCCCCTGCTGCCATCCCAGTACTGGT
ACTACATTTTAGAAATGAGTTTTTATTGGTCTCTGTTATTTAGACTTGGCTTTGATGTCAAGAGAAAGGATTTTCTAGCTCATATCATCC
ACCACCTGGCTGCTATTAGTCTGATGAGCTTCTCTTGGTGTGCTAATTATATTCGCAGTGGGACCCTCGTGATGATTGTACACGATGTGG
CTGACATTTGGCTGGAGTCTGCTAAGATGTTTTCTTATGCTGGATGGACGCAGACCTGTAACACCCTGTTTTTCATCTTCTCCACCATAT
TTTTCATCAGCCGCCTCATTGTTTTTCCTTTCTGGATTTTATATTGCACGCTGATCTTGCCTATGTATCACCTCGAGCCTTTCTTTTCAT
ACATCTTCCTCAACCTACAGCTCATGATCTTGCAGGTCCTTCACCTTTACTGGGGTTATTACATCTTGAAGATGCTCAACAGATGTATAT
TCATGAAGAGCATCCAGGATGTGAGGAGTGATGACGAGGATTATGAAGAGGAAGAGGAAGAGGAAGAAGAAGAGGCTACCAAAGGCAAAG
AGATGGATTGTTTAAAGAACGGCCTCAGGGCTGAGAGGCACCTCATTCCCAATGGCCAGCATGGCCATTAGCTGGAAGCCTACAGGACTC
CCATGGCACAGCATGCTGCAAGTACTGTTGGCAGCCTGGCTTCCAGGCCCCACACCGACCCCACATTCTGCCCTTCCCTCTTTCTCACCA
CCGCCTTCCCTCCCACCTAAGATGTGTTTACCAAAATGTTGTTAACTTGTGTTAAAATGTTAAATATAAGCATGCCCATGGATTTTTACT

>5301_5301_9_AP3S2-CERS3_AP3S2_chr15_90414707_ENST00000560940_CERS3_chr15_101024873_ENST00000538112_length(amino acids)=410AA_BP=123
MREPWLAKMIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSES
ELGILDLIQVFVETLDKCFENVCELDLIFHMDKTDIYGLAKKCNLTERQVERWFRSRRNQERPSRLKKFQEACWRFAFYLMITVAGIAFL
YDKPWLYDLWEVWNGYPKQPLLPSQYWYYILEMSFYWSLLFRLGFDVKRKDFLAHIIHHLAAISLMSFSWCANYIRSGTLVMIVHDVADI
WLESAKMFSYAGWTQTCNTLFFIFSTIFFISRLIVFPFWILYCTLILPMYHLEPFFSYIFLNLQLMILQVLHLYWGYYILKMLNRCIFMK

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for AP3S2-CERS3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for AP3S2-CERS3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for AP3S2-CERS3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source