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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:AP3S2-GAREM (FusionGDB2 ID:5302)

Fusion Gene Summary for AP3S2-GAREM

Fusion gene summary

Fusion gene information	Fusion gene name: AP3S2-GAREM
	Fusion gene ID: 5302
		Hgene	Tgene
	Gene symbol	AP3S2	GAREM
	Gene ID	10239	64762
	Gene name	adaptor related protein complex 3 subunit sigma 2	GRB2 associated regulator of MAPK1 subtype 1
	Synonyms	AP3S3\|sigma3b	C18orf11\|FAM59A\|GAREM\|Gm944
	Cytomap	15q26.1	18q12.1
	Type of gene	protein-coding	protein-coding
	Description	AP-3 complex subunit sigma-2AP-3 complex subunit sigma-3Badapter-related protein complex 3 subunit sigma-2adaptor complex sigma3Badaptor related protein complex 3 sigma 2 subunitclathrin-associated/assembly/adaptor protein, small 4, 22-kDsigma-3B-ad	GRB2-associated and regulator of MAPK protein 1GRB2 associated regulator of MAPK1 1GRB2 associated, regulator of MAPK1GRB2-associated and regulator of MAPK1Grb2-associated and regulator of Erk/MAPKfamily with sequence similarity 59, member Aprotein
	Modification date	20200313	20200327
	UniProtAcc	.	Q75VX8
	Ensembl transtripts involved in fusion gene	ENST00000336418, ENST00000558011, ENST00000560940, ENST00000560771,	ENST00000578619, ENST00000269209, ENST00000399218,
Fusion gene scores	* DoF score	3 X 1 X 2=6	4 X 3 X 3=36
	# samples	3	3
	** MAII score	log2(3/6*10)=2.32192809488736	log2(3/36*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: AP3S2 [Title/Abstract] AND GAREM [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	AP3S2(90414707)-GAREM(29868166), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	GAREM	GO:0007173	epidermal growth factor receptor signaling pathway	19509291
Tgene	GAREM	GO:0008284	positive regulation of cell proliferation	19509291
Tgene	GAREM	GO:0071364	cellular response to epidermal growth factor stimulus	19509291

Fusion gene breakpoints across AP3S2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across GAREM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-CD-A4MH-01A	AP3S2	chr15	90414707	-	GAREM	chr18	29868166	-

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Fusion Gene ORF analysis for AP3S2-GAREM

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000336418	ENST00000578619	AP3S2	chr15	90414707	-	GAREM	chr18	29868166	-
5CDS-5UTR	ENST00000558011	ENST00000578619	AP3S2	chr15	90414707	-	GAREM	chr18	29868166	-
5CDS-5UTR	ENST00000560940	ENST00000578619	AP3S2	chr15	90414707	-	GAREM	chr18	29868166	-
In-frame	ENST00000336418	ENST00000269209	AP3S2	chr15	90414707	-	GAREM	chr18	29868166	-
In-frame	ENST00000336418	ENST00000399218	AP3S2	chr15	90414707	-	GAREM	chr18	29868166	-
In-frame	ENST00000558011	ENST00000269209	AP3S2	chr15	90414707	-	GAREM	chr18	29868166	-
In-frame	ENST00000558011	ENST00000399218	AP3S2	chr15	90414707	-	GAREM	chr18	29868166	-
In-frame	ENST00000560940	ENST00000269209	AP3S2	chr15	90414707	-	GAREM	chr18	29868166	-
In-frame	ENST00000560940	ENST00000399218	AP3S2	chr15	90414707	-	GAREM	chr18	29868166	-
intron-3CDS	ENST00000560771	ENST00000269209	AP3S2	chr15	90414707	-	GAREM	chr18	29868166	-
intron-3CDS	ENST00000560771	ENST00000399218	AP3S2	chr15	90414707	-	GAREM	chr18	29868166	-
intron-5UTR	ENST00000560771	ENST00000578619	AP3S2	chr15	90414707	-	GAREM	chr18	29868166	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000336418	AP3S2	chr15	90414707	-	ENST00000399218	GAREM	chr18	29868166	-	7322	738	369	2972	867
ENST00000336418	AP3S2	chr15	90414707	-	ENST00000269209	GAREM	chr18	29868166	-	3347	738	369	2975	868
ENST00000558011	AP3S2	chr15	90414707	-	ENST00000399218	GAREM	chr18	29868166	-	7010	426	21	2660	879
ENST00000558011	AP3S2	chr15	90414707	-	ENST00000269209	GAREM	chr18	29868166	-	3035	426	21	2663	880
ENST00000560940	AP3S2	chr15	90414707	-	ENST00000399218	GAREM	chr18	29868166	-	6961	377	8	2611	867
ENST00000560940	AP3S2	chr15	90414707	-	ENST00000269209	GAREM	chr18	29868166	-	2986	377	8	2614	868

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000336418	ENST00000399218	AP3S2	chr15	90414707	-	GAREM	chr18	29868166	-	0.000345146	0.9996549
ENST00000336418	ENST00000269209	AP3S2	chr15	90414707	-	GAREM	chr18	29868166	-	0.00326142	0.9967386
ENST00000558011	ENST00000399218	AP3S2	chr15	90414707	-	GAREM	chr18	29868166	-	0.00029523	0.9997048
ENST00000558011	ENST00000269209	AP3S2	chr15	90414707	-	GAREM	chr18	29868166	-	0.002004565	0.9979955
ENST00000560940	ENST00000399218	AP3S2	chr15	90414707	-	GAREM	chr18	29868166	-	0.000311549	0.9996885
ENST00000560940	ENST00000269209	AP3S2	chr15	90414707	-	GAREM	chr18	29868166	-	0.002589451	0.9974106

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Fusion Genomic Features for AP3S2-GAREM

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for AP3S2-GAREM

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:90414707/chr18:29868166)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	GAREM Q75VX8
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway. {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

GAREM

chr15:90414707

chr18:29868166

ENST00000269209

512_566

131

877.0

Compositional bias

Note=Pro-rich

Tgene

GAREM

chr15:90414707

chr18:29868166

ENST00000399218

512_566

131

876.0

Compositional bias

Note=Pro-rich

Tgene

GAREM

chr15:90414707

chr18:29868166

ENST00000269209

811_876

131

877.0

Domain

Note=SAM

Tgene

GAREM

chr15:90414707

chr18:29868166

ENST00000399218

811_876

131

876.0

Domain

Note=SAM

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

GAREM

chr15:90414707

chr18:29868166

ENST00000269209

12_320

131

877.0

Region

Note=CABIT

Tgene

GAREM

chr15:90414707

chr18:29868166

ENST00000399218

12_320

131

876.0

Region

Note=CABIT

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Fusion Gene Sequence for AP3S2-GAREM

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>5302_5302_1_AP3S2-GAREM_AP3S2_chr15_90414707_ENST00000336418_GAREM_chr18_29868166_ENST00000269209_length(transcript)=3347nt_BP=738nt
ACGTTCTGCGAGCGCTAAGGGGATGGCGGGAGTGCATGATTTGGAGCGGGCGGTGAGAAAAGCAAGCTCCCGCCGCCTCTCCGTTTTGGC
AACCCGGCTGACGGTCGTTTCGGCTTCTGGGGCCAGCCGTCGGTCTGGGCGAGGGACATAGATCCGGATTCGCATCCTGACTGGCCAACC
AACGCTGGCCGAGGTGACCACTCTCCTCGGCATCCGCACCTGCCCTCCAAGGCGTCAGAGAGGCCGGACCCTTGGGTGCTAGGGCTCGTG
AGCGCCGGGGCCAAGTTTCCGAGTGCCGCTCTCAGCAGCGCACCAACCGGAAGTGATCGTGTTGTGGCGGAAGGAGGAGCTTTCTGGGAG
TAGCCGGTGCTGAGAGAACCGTGGCTGGCAAAGATGATTCAGGCGATTCTGGTTTTCAACAACCATGGGAAGCCACGGCTAGTCCGCTTC
TACCAGCGTTTCCCAGAAGAAATTCAACAGCAGATTGTTCGAGAGACTTTCCATCTAGTCCTCAAGCGGGATGACAACATCTGTAACTTC
TTGGAGGGTGGAAGTTTGATTGGTGGCTCTGACTACAAACTGATCTACCGGCACTATGCTACCCTCTACTTTGTATTTTGTGTGGATTCC
TCAGAGAGTGAACTTGGAATCTTGGACCTCATCCAGGTTTTTGTGGAAACTCTGGATAAGTGTTTCGAAAATGTGTGTGAATTGGATTTG
ATCTTCCATATGGATAAGGTTGCTTCAGGTGAATGCAATGAAGACACTGAAGTTTACAACATCACCCTGTGTACTGGGGATGAACTCACT
CTAATGGGGCAGGCAGAAATCCTTTATGCAAAGACATTCAAGGAAAAGTCACGACTCAACACAATCTTCAAAAAGATTGGGAAGCTCAAT
TCCATCAGCAAGCTGGGAAAAGGCAAAATGCCGTGCCTCATTTGTATGAATCACCGGACCAACGAAAGCATTAGCCTTCCATTCCAGTGC
AAGGGCAGATTTAGCACCCGAAGTCCCCTGGAACTTCAGATGCAAGAGGGCGAACACACCATCCGCAACATTGTGGAGAAAACCAGGCTT
CCTGTGAATGTGACTGTGCCAAGCCCTCCACCGAGAAACCCATACGACCTCCACTTCATCCGTGAGGGGCACCGCTATAAGTTTGTGAAC
ATCCAGACCAAGACGGTGGTGGTTTGCTGTGTGCTGCGGAACAACAAGATCCTCCCCATGCACTTTCCTTTGCACTTGACTGTCCCCAAG
TTCAGCCTCCCAGAACACCTGGTGAAGGGAGAGAGCTGGCCCGAAACCCTGGTCCATCACTGGCTAGGTATCTGCCAAGAACAGTTCGAC
ATCGATGAGTATTCACGGGCTGTCCGTGATGTGAAAACCGACTGGAATGAAGAATGCAAGAGCCCCAAGAAGGGTCGGTGCTCTGGCCAC
AACCACGTGCCCAATTCGCTCAGCTACGCCCGCGATGAGCTCACCCAGTCCTTCCACCGACTCTCGGTCTGTGTGTATGGCAACAATCTC
CATGGCAACAGTGAGGTGAACCTTCATGGTTGCAGGGACCTGGGGGGAGATTGGGCTCCCTTTCCTCATGACATCCTGCCCTATCAGGAC
TCTGGAGATAGTGGGAGCGACTACCTTTTCCCAGAAGCTAGTGAAGAATCAGCAGGCATCCCGGGAAAGTCAGAACTTCCCTACGAAGAG
CTGTGGCTGGAGGAAGGCAAGCCCAGCCATCAGCCTCTCACTCGCTCTCTGAGCGAGAAGAACAGATGTGATCAGTTTAGAGGTTCTGTC
CGATCCAAATGTGCGACTTCTCCTCTTCCCATCCCTGGGACTCTGGGAGCAGCAGTGAAGTCTTCAGATACTGCCCTACCTCCACCTCCA
GTGCCTCCCAAATCTGAAGCCGTCAGAGAAGAATGCCGGCTCCTGAACGCCCCACCTGTTCCACCCCGAAGCGCAAAGCCTTTGTCCACC
AGTCCCTCCATCCCTCCTCGCACAGTCAAGCCAGCGCGGCAACAGACTCGCTCTCCCAGCCCCACCTTGTCCTACTATTCTTCAGGGCTA
CACAACATCAGCGTCACTAAAACTGACACAAATCCTTCTGAAAGCACTCCTGTTTCCTGCTATCCATGTAACCGAGTGAAAACTGATTCT
GTGGACCTGAAATCCCCGTTTGGAAGTCCTTCTGCTGAAGCTGTGTCCTCTCGGCTCTCATGGCCTAACCATTATTCAGGAGCATCAGAA
AGCCAGACCAGGAGTGACTTCCTGCTGGATCCAAGCAGGAGTTATAGTTACCCTAGACAAAAGACGCCAGGCACACCAAAGAGAAACTGC
CCAGCACCTTTTGATTTTGATGGCTGTGAGCTCCTGGCCAGCCCCACTAGCCCAGTCACTGCAGAATTCAGTAGCAGCGTCTCTGGTTGT
CCCAAGTCAGCCAGCTACTCTCTGGAGAGCACAGATGTGAAATCTCTTGCAGCTGGTGTGACAAAGCAGAGTACGTCATGCCCTGCCTTA
CCCCCCAGGGCTCCAAAACTAGTGGAAGAGAAGGTCGCCTCCGAAACATCTCCTTTGCCTCTGAAAATTGATGGTGCTGAGGAAGACCCC
AAGTCTGGGTCACCAGATCTCTCGGAGGACCAGTATTTTGTTAAAAAGGGCATGCAGGACATCTTCTCTGCCTCCTACCCTTTCTCATCT
CCGCTCCATCTCCAGCTGGCCCCCAGATCCTGTGGCGACGGTTCCCCATGGCAGCCACCTGCTGACCTATCAGGACTCTCTATAGAGGAA
GTGTCCAAGTCACTACGGTTCATTGGTTTGTCCGAAGATGTCATATCATTCTTTGTTACTGAAAAGATTGATGGGAACCTGCTTGTTCAG
CTAACGGAAGAAATCCTCTCAGAGGATTTCAAATTGAGCAAATTGCAGGTGAAGAAGATAATGCAATTCATTAATGGCTGGAGGCCCAAA
ATATAGCCAAATAACCCCCGGCCAGCATGGAACAAAACTGATCAATGCGTGTGCTAGAAGGGGTGGGCTGGGACACAATTTCATGTTTTT
GCACTAAAAACCTTCTCTGTAAATAGGGATAAGAGAAACTCTTACTATGCAGATTACGTTTTTGAATGGTGAACAGGCTATTTTGTACAT
CAATAAAAATGCTGTACAGAACACTTGGAGGTGTGCCTTGTACGTCACTCAACAAACACTCAGCAGCTGCTAAAAGAAAAAAAGGCATGT
GCAGAGAAATCATTCTTACCCAAGTAGGTTTATGTGAGAAGGTATGATATTTATTACAAAATAGCCAAAGCTGGAAGACATAAAAATCTT

>5302_5302_1_AP3S2-GAREM_AP3S2_chr15_90414707_ENST00000336418_GAREM_chr18_29868166_ENST00000269209_length(amino acids)=868AA_BP=123
MREPWLAKMIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSES
ELGILDLIQVFVETLDKCFENVCELDLIFHMDKVASGECNEDTEVYNITLCTGDELTLMGQAEILYAKTFKEKSRLNTIFKKIGKLNSIS
KLGKGKMPCLICMNHRTNESISLPFQCKGRFSTRSPLELQMQEGEHTIRNIVEKTRLPVNVTVPSPPPRNPYDLHFIREGHRYKFVNIQT
KTVVVCCVLRNNKILPMHFPLHLTVPKFSLPEHLVKGESWPETLVHHWLGICQEQFDIDEYSRAVRDVKTDWNEECKSPKKGRCSGHNHV
PNSLSYARDELTQSFHRLSVCVYGNNLHGNSEVNLHGCRDLGGDWAPFPHDILPYQDSGDSGSDYLFPEASEESAGIPGKSELPYEELWL
EEGKPSHQPLTRSLSEKNRCDQFRGSVRSKCATSPLPIPGTLGAAVKSSDTALPPPPVPPKSEAVREECRLLNAPPVPPRSAKPLSTSPS
IPPRTVKPARQQTRSPSPTLSYYSSGLHNISVTKTDTNPSESTPVSCYPCNRVKTDSVDLKSPFGSPSAEAVSSRLSWPNHYSGASESQT
RSDFLLDPSRSYSYPRQKTPGTPKRNCPAPFDFDGCELLASPTSPVTAEFSSSVSGCPKSASYSLESTDVKSLAAGVTKQSTSCPALPPR
APKLVEEKVASETSPLPLKIDGAEEDPKSGSPDLSEDQYFVKKGMQDIFSASYPFSSPLHLQLAPRSCGDGSPWQPPADLSGLSIEEVSK

--------------------------------------------------------------
>5302_5302_2_AP3S2-GAREM_AP3S2_chr15_90414707_ENST00000336418_GAREM_chr18_29868166_ENST00000399218_length(transcript)=7322nt_BP=738nt
ACGTTCTGCGAGCGCTAAGGGGATGGCGGGAGTGCATGATTTGGAGCGGGCGGTGAGAAAAGCAAGCTCCCGCCGCCTCTCCGTTTTGGC
AACCCGGCTGACGGTCGTTTCGGCTTCTGGGGCCAGCCGTCGGTCTGGGCGAGGGACATAGATCCGGATTCGCATCCTGACTGGCCAACC
AACGCTGGCCGAGGTGACCACTCTCCTCGGCATCCGCACCTGCCCTCCAAGGCGTCAGAGAGGCCGGACCCTTGGGTGCTAGGGCTCGTG
AGCGCCGGGGCCAAGTTTCCGAGTGCCGCTCTCAGCAGCGCACCAACCGGAAGTGATCGTGTTGTGGCGGAAGGAGGAGCTTTCTGGGAG
TAGCCGGTGCTGAGAGAACCGTGGCTGGCAAAGATGATTCAGGCGATTCTGGTTTTCAACAACCATGGGAAGCCACGGCTAGTCCGCTTC
TACCAGCGTTTCCCAGAAGAAATTCAACAGCAGATTGTTCGAGAGACTTTCCATCTAGTCCTCAAGCGGGATGACAACATCTGTAACTTC
TTGGAGGGTGGAAGTTTGATTGGTGGCTCTGACTACAAACTGATCTACCGGCACTATGCTACCCTCTACTTTGTATTTTGTGTGGATTCC
TCAGAGAGTGAACTTGGAATCTTGGACCTCATCCAGGTTTTTGTGGAAACTCTGGATAAGTGTTTCGAAAATGTGTGTGAATTGGATTTG
ATCTTCCATATGGATAAGGTTGCTTCAGGTGAATGCAATGAAGACACTGAAGTTTACAACATCACCCTGTGTACTGGGGATGAACTCACT
CTAATGGGGCAGGCAGAAATCCTTTATGCAAAGACATTCAAGGAAAAGTCACGACTCAACACAATCTTCAAAAAGATTGGGAAGCTCAAT
TCCATCAGCAAGCTGGGAAAAGGCAAAATGCCGTGCCTCATTTGTATGAATCACCGGACCAACGAAAGCATTAGCCTTCCATTCCAGTGC
AAGGGCAGATTTAGCACCCGAAGTCCCCTGGAACTTCAGATGCAAGAGGGCGAACACACCATCCGCAACATTGTGGAGAAAACCAGGCTT
CCTGTGAATGTGACTGTGCCAAGCCCTCCACCGAGAAACCCATACGACCTCCACTTCATCCGTGAGGGGCACCGCTATAAGTTTGTGAAC
ATCCAGACCAAGACGGTGGTGGTTTGCTGTGTGCTGCGGAACAACAAGATCCTCCCCATGCACTTTCCTTTGCACTTGACTGTCCCCAAG
TTCAGCCTCCCAGAACACCTGGTGAAGGGAGAGAGCTGGCCCGAAACCCTGGTCCATCACTGGCTAGGTATCTGCCAAGAACAGTTCGAC
ATCGATGAGTATTCACGGGCTGTCCGTGATGTGAAAACCGACTGGAATGAAGAATGCAAGAGCCCCAAGAAGGGTCGGTGCTCTGGCCAC
AACCACGTGCCCAATTCGCTCAGCTACGCCCGCGATGAGCTCACCCAGTCCTTCCACCGACTCTCGGTCTGTGTGTATGGCAACAATCTC
CATGGCAACAGTGAGGTGAACCTTCATGGTTGCAGGGACCTGGGGGGAGATTGGGCTCCCTTTCCTCATGACATCCTGCCCTATCAGGAC
TCTGGAGATAGTGGGAGCGACTACCTTTTCCCAGAAGCTAGTGAAGAATCAGCAGGCATCCCGGGAAAGTCAGAACTTCCCTACGAAGAG
CTGTGGCTGGAGGAAGGCAAGCCCAGCCATCAGCCTCTCACTCGCTCTCTGAGCGAGAAGAACAGATGTGATCAGTTTAGAGGTTCTGTC
CGATCCAAATGTGCGACTTCTCCTCTTCCCATCCCTGGGACTCTGGGAGCAGCAGTGAAGTCTTCAGATACTGCCCTACCTCCACCTCCA
GTGCCTCCCAAATCTGAAGCCGTCAGAGAAGAATGCCGGCTCCTGAACGCCCCACCTGTTCCACCCCGAAGCGCAAAGCCTTTGTCCACC
AGTCCCTCCATCCCTCCTCGCACAGTCAAGCCAGCGCGGCAACAGACTCGCTCTCCCAGCCCCACCTTGTCCTACTATTCTTCAGGGCTA
CACAACATCGTCACTAAAACTGACACAAATCCTTCTGAAAGCACTCCTGTTTCCTGCTATCCATGTAACCGAGTGAAAACTGATTCTGTG
GACCTGAAATCCCCGTTTGGAAGTCCTTCTGCTGAAGCTGTGTCCTCTCGGCTCTCATGGCCTAACCATTATTCAGGAGCATCAGAAAGC
CAGACCAGGAGTGACTTCCTGCTGGATCCAAGCAGGAGTTATAGTTACCCTAGACAAAAGACGCCAGGCACACCAAAGAGAAACTGCCCA
GCACCTTTTGATTTTGATGGCTGTGAGCTCCTGGCCAGCCCCACTAGCCCAGTCACTGCAGAATTCAGTAGCAGCGTCTCTGGTTGTCCC
AAGTCAGCCAGCTACTCTCTGGAGAGCACAGATGTGAAATCTCTTGCAGCTGGTGTGACAAAGCAGAGTACGTCATGCCCTGCCTTACCC
CCCAGGGCTCCAAAACTAGTGGAAGAGAAGGTCGCCTCCGAAACATCTCCTTTGCCTCTGAAAATTGATGGTGCTGAGGAAGACCCCAAG
TCTGGGTCACCAGATCTCTCGGAGGACCAGTATTTTGTTAAAAAGGGCATGCAGGACATCTTCTCTGCCTCCTACCCTTTCTCATCTCCG
CTCCATCTCCAGCTGGCCCCCAGATCCTGTGGCGACGGTTCCCCATGGCAGCCACCTGCTGACCTATCAGGACTCTCTATAGAGGAAGTG
TCCAAGTCACTACGGTTCATTGGTTTGTCCGAAGATGTCATATCATTCTTTGTTACTGAAAAGATTGATGGGAACCTGCTTGTTCAGCTA
ACGGAAGAAATCCTCTCAGAGGATTTCAAATTGAGCAAATTGCAGGTGAAGAAGATAATGCAATTCATTAATGGCTGGAGGCCCAAAATA
TAGCCAAATAACCCCCGGCCAGCATGGAACAAAACTGATCAATGCGTGTGCTAGAAGGGGTGGGCTGGGACACAATTTCATGTTTTTGCA
CTAAAAACCTTCTCTGTAAATAGGGATAAGAGAAACTCTTACTATGCAGATTACGTTTTTGAATGGTGAACAGGCTATTTTGTACATCAA
TAAAAATGCTGTACAGAACACTTGGAGGTGTGCCTTGTACGTCACTCAACAAACACTCAGCAGCTGCTAAAAGAAAAAAAGGCATGTGCA
GAGAAATCATTCTTACCCAAGTAGGTTTATGTGAGAAGGTATGATATTTATTACAAAATAGCCAAAGCTGGAAGACATAAAAATCTTTAA
AAAAAAAAAAAAAACACTTTTGAACAAGTCCCTTCTTTCAGGAGGGTTGACTTTAGACAATTAACTGTGTTCTGTGCTCTGTCATTCAGA
TTGCTTCTTGCTAATTGTTTTACTCTTGTGCCTGAAAATGTTAGTGATACGAATTGACACTTTAATGTTGTATGCTTGGTGGGGATCTTT
TTATCACAAGGCATTTTCCAAGAGTCATATGTTGATAAAGGGATATATGTTGTCCTTAGAAATCACACAAATCATGACCACAATAATTTA
TCTGTAACTGCTGCTAATTTTATTGAGCAGAGAAAAAAGAATATACATATATAAACATGTATAGGTGCATACACAATACACCCGGATATG
TTTTACACATAATTTTGATTCTGATATTTTAGATAACATCTGTTCACTTTTAAACAATCTGTTGAGGTTTTGGGACTGTTATCTACATTG
ATTCTCTTAGGAATAGTGGACAGAATGACTCCAAAGATTCTCAGAACCCTGTCTCTTGAAGCTCAATCTTATTTGGGTTCATCACTGAAA
ACTTAGAACAAATCAGTAAAGAATCCTGTATTGAAGAATTAAGTTTGAGTTTAAGCCCACTCACCGCAGGGCTGGTTTTTGCATGTAATA
CTCCCATGATGTCTGGGGAAATGACAGTTTCTGTTGAATTATAATTCTCCGGTTTAAGGGTCTCCTTCCCCTGGTGTCTGATGGTGAGAG
GTCTGAAGAGCATTTGTCAGAGTACATTAGGCATTCTCAACCTACTTCATGCTTTACGAGAGCTGAGAAATCAGACGCACCGGCCTTTAT
TATTATATATGCTACATCTGTTGAGTATTTTTAAAATACCAATAAGAGGACTTGTTTATTTCATAAACCACTTCTTCCCTCTCTTTCAAA
GAAAATACATTATTACCATACTTTTACATTAGTCTGAGAATTTTTGCTAAATATGATTAAGTATTCCAAAATATAATGGCGTCATTATTC
TTGACTTTTTTAGAGAATATACATCTTAAGACTGTATTAGTTCTCAGAGCAAGGCATCATCTACTCCCCTGCACCTGAGAGTCTGGCCCC
AGATTCCAGATGTGCGGACAGCCCATGACCGAGGTGCACACAGTGCCCTCTTGAATAGGAAGGTCAGCCAGTGAGGCGGCAGCATAACTT
GCAGGATGGACTTATATCTTACCATCTCTTCCTGCTACCAAAATAAAAAAATAAATTGAAAGACAAGACCCACCAGTCTAGTTTTGTAGA
CCTGTGAAATGTGTCTTTATTTCTTGGCATTAGAAGAAAGATATTTTTAATCCATATCGTGGTTTTAGAGTTGAAGTGAATTGATACCCA
ATTTTCCATCTTAGATCTCCTTTATCAAAAAAAAAAGCATTTTTTTTCTCCTAACGTGTCTCCCAAAATGTAAATACTATAGGCAAAAAG
AGTACCCTGTAAAATTCTCACACTGGAGCACCTCTTCAAAAGTCACAGATAACTCAATGAGGAAGTGCTGGTACTGCACTCACAGGACAT
GAGACCTATGAAGCTTTCGTGTTTTGAAAGCATCCTTCTGTGTGAGGGGGACTGCCTCCCTTAGTAAAGTAAACCTCTCAGAACTTCTTT
TTAAAATAAAAACAGACAAGATGCAGTTACTAAGCTGCAAGTTTTCATTGGCAAACCTAGCTGAATCCGTTTTAAAATACTTAGCACTCG
GACACAATTCTCAAACTCAGGAAGAAGGAACAGGGTTGGTTTGGGTTTACTATAAAGGTTGCCTCACATAAACAACTGACTCCTTTTAGC
GTTTTTTTTCTTTTTGTAAAAACTTTACACAAAATAGGGTTTTAAATTCTTTTTGCTTGTTTTGGACTTGGTGTATTTTTGTCAAGTTTA
TATTGATTGGCAACGCAGAGACTCCTTGAGGGCAGGGACTGTGGCCTTTGATTCACTTATGCTACAGTCTAGTATCACTACAGTGCTGAG
TAAAAGACACAGCCCCTGCCCTCTTGGAGATCATATTGTTTATATTTGAAATCTCAGTTGCTAAGAGTATGTATGTGTGAGTAAGAAAGA
CGTGAAGTCCTATGGGCAGCTGGGTATATGGAGAATTACGTGTGTCCTGTCTTTAAAACGTCAGCCTCTATTAAGGGGTACAGAACACCC
CAAGATCACTAAAACTTGGAATGTGTTGGAGGCAGAAAGTATCTCTCTCATTGCCTAGTGTTGTTGTTTTTTTGTTTTTTGTTTTTTGTT
TTTTTTACTGACCTGGAATTCTTTTAATTGTAATAAATATCTTCTGTCACAAATAAATGCCACAAATAAATGAAATTGCCATTCCTAAGC
TGAGCACCTGTCTGTGAAGGACCTTGGTGTCCTGACTGGACAGAGCATTCATAGCTCCAAGAGAATCATGACAAGATATGCAAAGCAGGG
ATAATAAGGAGAAAGCCCTTCCCTTTCGAGAAGCCCTTCCCTTTCACAGCCCTTCCCTGCGATTCTGCAGTGAAAAGTGATGCCCAGAGA
TCCACACACAGAACCCTTCTAACCAGCCAGGTCAAGACTTATCATCTTATCTCCTCTGGCAGGTCCCCTGTAATCAAAAGAGAGGAAGTG
TCTATCTAAACAAGACCCTTTTGGGTCCTTAGATTCATGGCAAAAATCATCATGGCCCCCATCAGAAAAGAAAATCAGCAATAAACCAAG
CCAAGCAACTAAAATGTATAATGTGGACCTGACTCATGTTGGGAGGCAGAATTCAGACACTCACAGATCAATCTTGCAAGTTTTCTCTTC
TTTAAGTTGAGCTGCTCAACTTTATGAACTGTGAAATTTACTTACATTCTTTCAACCCACATATATCATTGCAGTTTATGAAGTTGCAGT
GAACTGCCCATTCAGCTAAATTGCAGTGTTTATTCTTGTCTCATGTCGAAATACAACAATCTTATGGGAAATATTATGACAGTCCGTTCC
AACTGTTCTCAGACACATGCATAAACAGTCTCTGCTCACATTCCACAGCCACCTGCATGTTATCCATACAGCTCCCTGAGAAGTCCAGGG
ATGGGAGGTGGGGTGTGGAAGGATGGAGGGTCCTTCATTTTCTAAACACTTTGTATAAGTCACTACTCATCGTGCCTAGCAAGTATAAGA
TTAACATTTTGAATAACAAACTGGAAAACAAATAATCCTTCAAAGAACCTAGCGAACTGTTCAAAGGAAATTTTAATTTCAGTCTACCAG
AAAAGTTAAATCTGTTGTTGGACGTAGGGGGCTTTCAGAAACATGCCTCTTATATCAATTTCCACTATCTTTCAAGTTACCTAAAGGCAC
CAGGCTGCTTGAGCAAGAAGAATAAAAGGCCTAGAGTGCAAATTATGTGAAGTAGAGTTTTTAGATTGTGGGATTGTAATAATACGGGAT
TCTCATGGTTACATCATGTTAAATCACACTGTTCAGTCTTTAAAACTTGGTGTTTTAAAATTTGTCTCATTGTGATAGCCAGAAACAAGG
AATAAACGTGATTTCAGTTTAAACTATATACAAATATCTTCTGTAATTTTGCTGCTCTAATTTTTAGGCTATAAATTTTGTAATAGAGCT
TATCAGATCGCAAATTTCCTTTGTTTACAATCTCATGTAGTAGGGCTCAGATAATTTCTTAGCTATAAACCTTTTCTCCCACTCTCATAT
TGTTTCATTTAAAATATTTAAGCTAAGCCTAAAAATTGAAATCAGTTAAGAATTTGGAGAGTTTATCTTAAATGGAAATGGTGTATTCTT
TTCAAAGAATTTTGTAACCATCTTTACAGTTTCTTTGCTTGGAAAACTTGGGTTGTTAACTACCAGTTAACAATGGCATTACTTTCCAAA
ACGTTATCTAATGGGCCCAATGTGTACCTCAAGATAAACACAGTATGTTATGTCTAAAAATTTCCTTGTCTGTTGATTTAAATGGTTCTG

>5302_5302_2_AP3S2-GAREM_AP3S2_chr15_90414707_ENST00000336418_GAREM_chr18_29868166_ENST00000399218_length(amino acids)=867AA_BP=123
MREPWLAKMIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSES
ELGILDLIQVFVETLDKCFENVCELDLIFHMDKVASGECNEDTEVYNITLCTGDELTLMGQAEILYAKTFKEKSRLNTIFKKIGKLNSIS
KLGKGKMPCLICMNHRTNESISLPFQCKGRFSTRSPLELQMQEGEHTIRNIVEKTRLPVNVTVPSPPPRNPYDLHFIREGHRYKFVNIQT
KTVVVCCVLRNNKILPMHFPLHLTVPKFSLPEHLVKGESWPETLVHHWLGICQEQFDIDEYSRAVRDVKTDWNEECKSPKKGRCSGHNHV
PNSLSYARDELTQSFHRLSVCVYGNNLHGNSEVNLHGCRDLGGDWAPFPHDILPYQDSGDSGSDYLFPEASEESAGIPGKSELPYEELWL
EEGKPSHQPLTRSLSEKNRCDQFRGSVRSKCATSPLPIPGTLGAAVKSSDTALPPPPVPPKSEAVREECRLLNAPPVPPRSAKPLSTSPS
IPPRTVKPARQQTRSPSPTLSYYSSGLHNIVTKTDTNPSESTPVSCYPCNRVKTDSVDLKSPFGSPSAEAVSSRLSWPNHYSGASESQTR
SDFLLDPSRSYSYPRQKTPGTPKRNCPAPFDFDGCELLASPTSPVTAEFSSSVSGCPKSASYSLESTDVKSLAAGVTKQSTSCPALPPRA
PKLVEEKVASETSPLPLKIDGAEEDPKSGSPDLSEDQYFVKKGMQDIFSASYPFSSPLHLQLAPRSCGDGSPWQPPADLSGLSIEEVSKS

--------------------------------------------------------------
>5302_5302_3_AP3S2-GAREM_AP3S2_chr15_90414707_ENST00000558011_GAREM_chr18_29868166_ENST00000269209_length(transcript)=3035nt_BP=426nt
GCTTTCTGGGAGTAGCCGGTGCTGAGAGAACCGTGGCTGGCAAAGATGATTCAGGCGATTCTGGTTTTCAACAACCATGGGAAGCCACGG
CTAGTCCGCTTCTACCAGCGTTTCCCAGAAGAAATTCAACAGCAGATTGTTCGAGAGACTTTCCATCTAGTCCTCAAGCGGGATGACAAC
ATCTGTAACTTCTTGGAGGGTGGAAGTTTGATTGGTGGCTCTGACTACAAACTGATCTACCGGCACTATGCTACCCTCTACTTTGTATTT
TGTGTGGATTCCTCAGAGAGTGAACTTGGAATCTTGGACCTCATCCAGGTACATCTGGAAGTTGTTTTCTTCATAGCTCCCAAGGTTTTT
GTGGAAACTCTGGATAAGTGTTTCGAAAATGTGTGTGAATTGGATTTGATCTTCCATATGGATAAGGTTGCTTCAGGTGAATGCAATGAA
GACACTGAAGTTTACAACATCACCCTGTGTACTGGGGATGAACTCACTCTAATGGGGCAGGCAGAAATCCTTTATGCAAAGACATTCAAG
GAAAAGTCACGACTCAACACAATCTTCAAAAAGATTGGGAAGCTCAATTCCATCAGCAAGCTGGGAAAAGGCAAAATGCCGTGCCTCATT
TGTATGAATCACCGGACCAACGAAAGCATTAGCCTTCCATTCCAGTGCAAGGGCAGATTTAGCACCCGAAGTCCCCTGGAACTTCAGATG
CAAGAGGGCGAACACACCATCCGCAACATTGTGGAGAAAACCAGGCTTCCTGTGAATGTGACTGTGCCAAGCCCTCCACCGAGAAACCCA
TACGACCTCCACTTCATCCGTGAGGGGCACCGCTATAAGTTTGTGAACATCCAGACCAAGACGGTGGTGGTTTGCTGTGTGCTGCGGAAC
AACAAGATCCTCCCCATGCACTTTCCTTTGCACTTGACTGTCCCCAAGTTCAGCCTCCCAGAACACCTGGTGAAGGGAGAGAGCTGGCCC
GAAACCCTGGTCCATCACTGGCTAGGTATCTGCCAAGAACAGTTCGACATCGATGAGTATTCACGGGCTGTCCGTGATGTGAAAACCGAC
TGGAATGAAGAATGCAAGAGCCCCAAGAAGGGTCGGTGCTCTGGCCACAACCACGTGCCCAATTCGCTCAGCTACGCCCGCGATGAGCTC
ACCCAGTCCTTCCACCGACTCTCGGTCTGTGTGTATGGCAACAATCTCCATGGCAACAGTGAGGTGAACCTTCATGGTTGCAGGGACCTG
GGGGGAGATTGGGCTCCCTTTCCTCATGACATCCTGCCCTATCAGGACTCTGGAGATAGTGGGAGCGACTACCTTTTCCCAGAAGCTAGT
GAAGAATCAGCAGGCATCCCGGGAAAGTCAGAACTTCCCTACGAAGAGCTGTGGCTGGAGGAAGGCAAGCCCAGCCATCAGCCTCTCACT
CGCTCTCTGAGCGAGAAGAACAGATGTGATCAGTTTAGAGGTTCTGTCCGATCCAAATGTGCGACTTCTCCTCTTCCCATCCCTGGGACT
CTGGGAGCAGCAGTGAAGTCTTCAGATACTGCCCTACCTCCACCTCCAGTGCCTCCCAAATCTGAAGCCGTCAGAGAAGAATGCCGGCTC
CTGAACGCCCCACCTGTTCCACCCCGAAGCGCAAAGCCTTTGTCCACCAGTCCCTCCATCCCTCCTCGCACAGTCAAGCCAGCGCGGCAA
CAGACTCGCTCTCCCAGCCCCACCTTGTCCTACTATTCTTCAGGGCTACACAACATCAGCGTCACTAAAACTGACACAAATCCTTCTGAA
AGCACTCCTGTTTCCTGCTATCCATGTAACCGAGTGAAAACTGATTCTGTGGACCTGAAATCCCCGTTTGGAAGTCCTTCTGCTGAAGCT
GTGTCCTCTCGGCTCTCATGGCCTAACCATTATTCAGGAGCATCAGAAAGCCAGACCAGGAGTGACTTCCTGCTGGATCCAAGCAGGAGT
TATAGTTACCCTAGACAAAAGACGCCAGGCACACCAAAGAGAAACTGCCCAGCACCTTTTGATTTTGATGGCTGTGAGCTCCTGGCCAGC
CCCACTAGCCCAGTCACTGCAGAATTCAGTAGCAGCGTCTCTGGTTGTCCCAAGTCAGCCAGCTACTCTCTGGAGAGCACAGATGTGAAA
TCTCTTGCAGCTGGTGTGACAAAGCAGAGTACGTCATGCCCTGCCTTACCCCCCAGGGCTCCAAAACTAGTGGAAGAGAAGGTCGCCTCC
GAAACATCTCCTTTGCCTCTGAAAATTGATGGTGCTGAGGAAGACCCCAAGTCTGGGTCACCAGATCTCTCGGAGGACCAGTATTTTGTT
AAAAAGGGCATGCAGGACATCTTCTCTGCCTCCTACCCTTTCTCATCTCCGCTCCATCTCCAGCTGGCCCCCAGATCCTGTGGCGACGGT
TCCCCATGGCAGCCACCTGCTGACCTATCAGGACTCTCTATAGAGGAAGTGTCCAAGTCACTACGGTTCATTGGTTTGTCCGAAGATGTC
ATATCATTCTTTGTTACTGAAAAGATTGATGGGAACCTGCTTGTTCAGCTAACGGAAGAAATCCTCTCAGAGGATTTCAAATTGAGCAAA
TTGCAGGTGAAGAAGATAATGCAATTCATTAATGGCTGGAGGCCCAAAATATAGCCAAATAACCCCCGGCCAGCATGGAACAAAACTGAT
CAATGCGTGTGCTAGAAGGGGTGGGCTGGGACACAATTTCATGTTTTTGCACTAAAAACCTTCTCTGTAAATAGGGATAAGAGAAACTCT
TACTATGCAGATTACGTTTTTGAATGGTGAACAGGCTATTTTGTACATCAATAAAAATGCTGTACAGAACACTTGGAGGTGTGCCTTGTA
CGTCACTCAACAAACACTCAGCAGCTGCTAAAAGAAAAAAAGGCATGTGCAGAGAAATCATTCTTACCCAAGTAGGTTTATGTGAGAAGG

>5302_5302_3_AP3S2-GAREM_AP3S2_chr15_90414707_ENST00000558011_GAREM_chr18_29868166_ENST00000269209_length(amino acids)=880AA_BP=135
MREPWLAKMIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSES
ELGILDLIQVHLEVVFFIAPKVFVETLDKCFENVCELDLIFHMDKVASGECNEDTEVYNITLCTGDELTLMGQAEILYAKTFKEKSRLNT
IFKKIGKLNSISKLGKGKMPCLICMNHRTNESISLPFQCKGRFSTRSPLELQMQEGEHTIRNIVEKTRLPVNVTVPSPPPRNPYDLHFIR
EGHRYKFVNIQTKTVVVCCVLRNNKILPMHFPLHLTVPKFSLPEHLVKGESWPETLVHHWLGICQEQFDIDEYSRAVRDVKTDWNEECKS
PKKGRCSGHNHVPNSLSYARDELTQSFHRLSVCVYGNNLHGNSEVNLHGCRDLGGDWAPFPHDILPYQDSGDSGSDYLFPEASEESAGIP
GKSELPYEELWLEEGKPSHQPLTRSLSEKNRCDQFRGSVRSKCATSPLPIPGTLGAAVKSSDTALPPPPVPPKSEAVREECRLLNAPPVP
PRSAKPLSTSPSIPPRTVKPARQQTRSPSPTLSYYSSGLHNISVTKTDTNPSESTPVSCYPCNRVKTDSVDLKSPFGSPSAEAVSSRLSW
PNHYSGASESQTRSDFLLDPSRSYSYPRQKTPGTPKRNCPAPFDFDGCELLASPTSPVTAEFSSSVSGCPKSASYSLESTDVKSLAAGVT
KQSTSCPALPPRAPKLVEEKVASETSPLPLKIDGAEEDPKSGSPDLSEDQYFVKKGMQDIFSASYPFSSPLHLQLAPRSCGDGSPWQPPA

--------------------------------------------------------------
>5302_5302_4_AP3S2-GAREM_AP3S2_chr15_90414707_ENST00000558011_GAREM_chr18_29868166_ENST00000399218_length(transcript)=7010nt_BP=426nt
GCTTTCTGGGAGTAGCCGGTGCTGAGAGAACCGTGGCTGGCAAAGATGATTCAGGCGATTCTGGTTTTCAACAACCATGGGAAGCCACGG
CTAGTCCGCTTCTACCAGCGTTTCCCAGAAGAAATTCAACAGCAGATTGTTCGAGAGACTTTCCATCTAGTCCTCAAGCGGGATGACAAC
ATCTGTAACTTCTTGGAGGGTGGAAGTTTGATTGGTGGCTCTGACTACAAACTGATCTACCGGCACTATGCTACCCTCTACTTTGTATTT
TGTGTGGATTCCTCAGAGAGTGAACTTGGAATCTTGGACCTCATCCAGGTACATCTGGAAGTTGTTTTCTTCATAGCTCCCAAGGTTTTT
GTGGAAACTCTGGATAAGTGTTTCGAAAATGTGTGTGAATTGGATTTGATCTTCCATATGGATAAGGTTGCTTCAGGTGAATGCAATGAA
GACACTGAAGTTTACAACATCACCCTGTGTACTGGGGATGAACTCACTCTAATGGGGCAGGCAGAAATCCTTTATGCAAAGACATTCAAG
GAAAAGTCACGACTCAACACAATCTTCAAAAAGATTGGGAAGCTCAATTCCATCAGCAAGCTGGGAAAAGGCAAAATGCCGTGCCTCATT
TGTATGAATCACCGGACCAACGAAAGCATTAGCCTTCCATTCCAGTGCAAGGGCAGATTTAGCACCCGAAGTCCCCTGGAACTTCAGATG
CAAGAGGGCGAACACACCATCCGCAACATTGTGGAGAAAACCAGGCTTCCTGTGAATGTGACTGTGCCAAGCCCTCCACCGAGAAACCCA
TACGACCTCCACTTCATCCGTGAGGGGCACCGCTATAAGTTTGTGAACATCCAGACCAAGACGGTGGTGGTTTGCTGTGTGCTGCGGAAC
AACAAGATCCTCCCCATGCACTTTCCTTTGCACTTGACTGTCCCCAAGTTCAGCCTCCCAGAACACCTGGTGAAGGGAGAGAGCTGGCCC
GAAACCCTGGTCCATCACTGGCTAGGTATCTGCCAAGAACAGTTCGACATCGATGAGTATTCACGGGCTGTCCGTGATGTGAAAACCGAC
TGGAATGAAGAATGCAAGAGCCCCAAGAAGGGTCGGTGCTCTGGCCACAACCACGTGCCCAATTCGCTCAGCTACGCCCGCGATGAGCTC
ACCCAGTCCTTCCACCGACTCTCGGTCTGTGTGTATGGCAACAATCTCCATGGCAACAGTGAGGTGAACCTTCATGGTTGCAGGGACCTG
GGGGGAGATTGGGCTCCCTTTCCTCATGACATCCTGCCCTATCAGGACTCTGGAGATAGTGGGAGCGACTACCTTTTCCCAGAAGCTAGT
GAAGAATCAGCAGGCATCCCGGGAAAGTCAGAACTTCCCTACGAAGAGCTGTGGCTGGAGGAAGGCAAGCCCAGCCATCAGCCTCTCACT
CGCTCTCTGAGCGAGAAGAACAGATGTGATCAGTTTAGAGGTTCTGTCCGATCCAAATGTGCGACTTCTCCTCTTCCCATCCCTGGGACT
CTGGGAGCAGCAGTGAAGTCTTCAGATACTGCCCTACCTCCACCTCCAGTGCCTCCCAAATCTGAAGCCGTCAGAGAAGAATGCCGGCTC
CTGAACGCCCCACCTGTTCCACCCCGAAGCGCAAAGCCTTTGTCCACCAGTCCCTCCATCCCTCCTCGCACAGTCAAGCCAGCGCGGCAA
CAGACTCGCTCTCCCAGCCCCACCTTGTCCTACTATTCTTCAGGGCTACACAACATCGTCACTAAAACTGACACAAATCCTTCTGAAAGC
ACTCCTGTTTCCTGCTATCCATGTAACCGAGTGAAAACTGATTCTGTGGACCTGAAATCCCCGTTTGGAAGTCCTTCTGCTGAAGCTGTG
TCCTCTCGGCTCTCATGGCCTAACCATTATTCAGGAGCATCAGAAAGCCAGACCAGGAGTGACTTCCTGCTGGATCCAAGCAGGAGTTAT
AGTTACCCTAGACAAAAGACGCCAGGCACACCAAAGAGAAACTGCCCAGCACCTTTTGATTTTGATGGCTGTGAGCTCCTGGCCAGCCCC
ACTAGCCCAGTCACTGCAGAATTCAGTAGCAGCGTCTCTGGTTGTCCCAAGTCAGCCAGCTACTCTCTGGAGAGCACAGATGTGAAATCT
CTTGCAGCTGGTGTGACAAAGCAGAGTACGTCATGCCCTGCCTTACCCCCCAGGGCTCCAAAACTAGTGGAAGAGAAGGTCGCCTCCGAA
ACATCTCCTTTGCCTCTGAAAATTGATGGTGCTGAGGAAGACCCCAAGTCTGGGTCACCAGATCTCTCGGAGGACCAGTATTTTGTTAAA
AAGGGCATGCAGGACATCTTCTCTGCCTCCTACCCTTTCTCATCTCCGCTCCATCTCCAGCTGGCCCCCAGATCCTGTGGCGACGGTTCC
CCATGGCAGCCACCTGCTGACCTATCAGGACTCTCTATAGAGGAAGTGTCCAAGTCACTACGGTTCATTGGTTTGTCCGAAGATGTCATA
TCATTCTTTGTTACTGAAAAGATTGATGGGAACCTGCTTGTTCAGCTAACGGAAGAAATCCTCTCAGAGGATTTCAAATTGAGCAAATTG
CAGGTGAAGAAGATAATGCAATTCATTAATGGCTGGAGGCCCAAAATATAGCCAAATAACCCCCGGCCAGCATGGAACAAAACTGATCAA
TGCGTGTGCTAGAAGGGGTGGGCTGGGACACAATTTCATGTTTTTGCACTAAAAACCTTCTCTGTAAATAGGGATAAGAGAAACTCTTAC
TATGCAGATTACGTTTTTGAATGGTGAACAGGCTATTTTGTACATCAATAAAAATGCTGTACAGAACACTTGGAGGTGTGCCTTGTACGT
CACTCAACAAACACTCAGCAGCTGCTAAAAGAAAAAAAGGCATGTGCAGAGAAATCATTCTTACCCAAGTAGGTTTATGTGAGAAGGTAT
GATATTTATTACAAAATAGCCAAAGCTGGAAGACATAAAAATCTTTAAAAAAAAAAAAAAAACACTTTTGAACAAGTCCCTTCTTTCAGG
AGGGTTGACTTTAGACAATTAACTGTGTTCTGTGCTCTGTCATTCAGATTGCTTCTTGCTAATTGTTTTACTCTTGTGCCTGAAAATGTT
AGTGATACGAATTGACACTTTAATGTTGTATGCTTGGTGGGGATCTTTTTATCACAAGGCATTTTCCAAGAGTCATATGTTGATAAAGGG
ATATATGTTGTCCTTAGAAATCACACAAATCATGACCACAATAATTTATCTGTAACTGCTGCTAATTTTATTGAGCAGAGAAAAAAGAAT
ATACATATATAAACATGTATAGGTGCATACACAATACACCCGGATATGTTTTACACATAATTTTGATTCTGATATTTTAGATAACATCTG
TTCACTTTTAAACAATCTGTTGAGGTTTTGGGACTGTTATCTACATTGATTCTCTTAGGAATAGTGGACAGAATGACTCCAAAGATTCTC
AGAACCCTGTCTCTTGAAGCTCAATCTTATTTGGGTTCATCACTGAAAACTTAGAACAAATCAGTAAAGAATCCTGTATTGAAGAATTAA
GTTTGAGTTTAAGCCCACTCACCGCAGGGCTGGTTTTTGCATGTAATACTCCCATGATGTCTGGGGAAATGACAGTTTCTGTTGAATTAT
AATTCTCCGGTTTAAGGGTCTCCTTCCCCTGGTGTCTGATGGTGAGAGGTCTGAAGAGCATTTGTCAGAGTACATTAGGCATTCTCAACC
TACTTCATGCTTTACGAGAGCTGAGAAATCAGACGCACCGGCCTTTATTATTATATATGCTACATCTGTTGAGTATTTTTAAAATACCAA
TAAGAGGACTTGTTTATTTCATAAACCACTTCTTCCCTCTCTTTCAAAGAAAATACATTATTACCATACTTTTACATTAGTCTGAGAATT
TTTGCTAAATATGATTAAGTATTCCAAAATATAATGGCGTCATTATTCTTGACTTTTTTAGAGAATATACATCTTAAGACTGTATTAGTT
CTCAGAGCAAGGCATCATCTACTCCCCTGCACCTGAGAGTCTGGCCCCAGATTCCAGATGTGCGGACAGCCCATGACCGAGGTGCACACA
GTGCCCTCTTGAATAGGAAGGTCAGCCAGTGAGGCGGCAGCATAACTTGCAGGATGGACTTATATCTTACCATCTCTTCCTGCTACCAAA
ATAAAAAAATAAATTGAAAGACAAGACCCACCAGTCTAGTTTTGTAGACCTGTGAAATGTGTCTTTATTTCTTGGCATTAGAAGAAAGAT
ATTTTTAATCCATATCGTGGTTTTAGAGTTGAAGTGAATTGATACCCAATTTTCCATCTTAGATCTCCTTTATCAAAAAAAAAAGCATTT
TTTTTCTCCTAACGTGTCTCCCAAAATGTAAATACTATAGGCAAAAAGAGTACCCTGTAAAATTCTCACACTGGAGCACCTCTTCAAAAG
TCACAGATAACTCAATGAGGAAGTGCTGGTACTGCACTCACAGGACATGAGACCTATGAAGCTTTCGTGTTTTGAAAGCATCCTTCTGTG
TGAGGGGGACTGCCTCCCTTAGTAAAGTAAACCTCTCAGAACTTCTTTTTAAAATAAAAACAGACAAGATGCAGTTACTAAGCTGCAAGT
TTTCATTGGCAAACCTAGCTGAATCCGTTTTAAAATACTTAGCACTCGGACACAATTCTCAAACTCAGGAAGAAGGAACAGGGTTGGTTT
GGGTTTACTATAAAGGTTGCCTCACATAAACAACTGACTCCTTTTAGCGTTTTTTTTCTTTTTGTAAAAACTTTACACAAAATAGGGTTT
TAAATTCTTTTTGCTTGTTTTGGACTTGGTGTATTTTTGTCAAGTTTATATTGATTGGCAACGCAGAGACTCCTTGAGGGCAGGGACTGT
GGCCTTTGATTCACTTATGCTACAGTCTAGTATCACTACAGTGCTGAGTAAAAGACACAGCCCCTGCCCTCTTGGAGATCATATTGTTTA
TATTTGAAATCTCAGTTGCTAAGAGTATGTATGTGTGAGTAAGAAAGACGTGAAGTCCTATGGGCAGCTGGGTATATGGAGAATTACGTG
TGTCCTGTCTTTAAAACGTCAGCCTCTATTAAGGGGTACAGAACACCCCAAGATCACTAAAACTTGGAATGTGTTGGAGGCAGAAAGTAT
CTCTCTCATTGCCTAGTGTTGTTGTTTTTTTGTTTTTTGTTTTTTGTTTTTTTTACTGACCTGGAATTCTTTTAATTGTAATAAATATCT
TCTGTCACAAATAAATGCCACAAATAAATGAAATTGCCATTCCTAAGCTGAGCACCTGTCTGTGAAGGACCTTGGTGTCCTGACTGGACA
GAGCATTCATAGCTCCAAGAGAATCATGACAAGATATGCAAAGCAGGGATAATAAGGAGAAAGCCCTTCCCTTTCGAGAAGCCCTTCCCT
TTCACAGCCCTTCCCTGCGATTCTGCAGTGAAAAGTGATGCCCAGAGATCCACACACAGAACCCTTCTAACCAGCCAGGTCAAGACTTAT
CATCTTATCTCCTCTGGCAGGTCCCCTGTAATCAAAAGAGAGGAAGTGTCTATCTAAACAAGACCCTTTTGGGTCCTTAGATTCATGGCA
AAAATCATCATGGCCCCCATCAGAAAAGAAAATCAGCAATAAACCAAGCCAAGCAACTAAAATGTATAATGTGGACCTGACTCATGTTGG
GAGGCAGAATTCAGACACTCACAGATCAATCTTGCAAGTTTTCTCTTCTTTAAGTTGAGCTGCTCAACTTTATGAACTGTGAAATTTACT
TACATTCTTTCAACCCACATATATCATTGCAGTTTATGAAGTTGCAGTGAACTGCCCATTCAGCTAAATTGCAGTGTTTATTCTTGTCTC
ATGTCGAAATACAACAATCTTATGGGAAATATTATGACAGTCCGTTCCAACTGTTCTCAGACACATGCATAAACAGTCTCTGCTCACATT
CCACAGCCACCTGCATGTTATCCATACAGCTCCCTGAGAAGTCCAGGGATGGGAGGTGGGGTGTGGAAGGATGGAGGGTCCTTCATTTTC
TAAACACTTTGTATAAGTCACTACTCATCGTGCCTAGCAAGTATAAGATTAACATTTTGAATAACAAACTGGAAAACAAATAATCCTTCA
AAGAACCTAGCGAACTGTTCAAAGGAAATTTTAATTTCAGTCTACCAGAAAAGTTAAATCTGTTGTTGGACGTAGGGGGCTTTCAGAAAC
ATGCCTCTTATATCAATTTCCACTATCTTTCAAGTTACCTAAAGGCACCAGGCTGCTTGAGCAAGAAGAATAAAAGGCCTAGAGTGCAAA
TTATGTGAAGTAGAGTTTTTAGATTGTGGGATTGTAATAATACGGGATTCTCATGGTTACATCATGTTAAATCACACTGTTCAGTCTTTA
AAACTTGGTGTTTTAAAATTTGTCTCATTGTGATAGCCAGAAACAAGGAATAAACGTGATTTCAGTTTAAACTATATACAAATATCTTCT
GTAATTTTGCTGCTCTAATTTTTAGGCTATAAATTTTGTAATAGAGCTTATCAGATCGCAAATTTCCTTTGTTTACAATCTCATGTAGTA
GGGCTCAGATAATTTCTTAGCTATAAACCTTTTCTCCCACTCTCATATTGTTTCATTTAAAATATTTAAGCTAAGCCTAAAAATTGAAAT
CAGTTAAGAATTTGGAGAGTTTATCTTAAATGGAAATGGTGTATTCTTTTCAAAGAATTTTGTAACCATCTTTACAGTTTCTTTGCTTGG
AAAACTTGGGTTGTTAACTACCAGTTAACAATGGCATTACTTTCCAAAACGTTATCTAATGGGCCCAATGTGTACCTCAAGATAAACACA

>5302_5302_4_AP3S2-GAREM_AP3S2_chr15_90414707_ENST00000558011_GAREM_chr18_29868166_ENST00000399218_length(amino acids)=879AA_BP=135
MREPWLAKMIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSES
ELGILDLIQVHLEVVFFIAPKVFVETLDKCFENVCELDLIFHMDKVASGECNEDTEVYNITLCTGDELTLMGQAEILYAKTFKEKSRLNT
IFKKIGKLNSISKLGKGKMPCLICMNHRTNESISLPFQCKGRFSTRSPLELQMQEGEHTIRNIVEKTRLPVNVTVPSPPPRNPYDLHFIR
EGHRYKFVNIQTKTVVVCCVLRNNKILPMHFPLHLTVPKFSLPEHLVKGESWPETLVHHWLGICQEQFDIDEYSRAVRDVKTDWNEECKS
PKKGRCSGHNHVPNSLSYARDELTQSFHRLSVCVYGNNLHGNSEVNLHGCRDLGGDWAPFPHDILPYQDSGDSGSDYLFPEASEESAGIP
GKSELPYEELWLEEGKPSHQPLTRSLSEKNRCDQFRGSVRSKCATSPLPIPGTLGAAVKSSDTALPPPPVPPKSEAVREECRLLNAPPVP
PRSAKPLSTSPSIPPRTVKPARQQTRSPSPTLSYYSSGLHNIVTKTDTNPSESTPVSCYPCNRVKTDSVDLKSPFGSPSAEAVSSRLSWP
NHYSGASESQTRSDFLLDPSRSYSYPRQKTPGTPKRNCPAPFDFDGCELLASPTSPVTAEFSSSVSGCPKSASYSLESTDVKSLAAGVTK
QSTSCPALPPRAPKLVEEKVASETSPLPLKIDGAEEDPKSGSPDLSEDQYFVKKGMQDIFSASYPFSSPLHLQLAPRSCGDGSPWQPPAD

--------------------------------------------------------------
>5302_5302_5_AP3S2-GAREM_AP3S2_chr15_90414707_ENST00000560940_GAREM_chr18_29868166_ENST00000269209_length(transcript)=2986nt_BP=377nt
AGCCGGTGCTGAGAGAACCGTGGCTGGCAAAGATGATTCAGGCGATTCTGGTTTTCAACAACCATGGGAAGCCACGGCTAGTCCGCTTCT
ACCAGCGTTTCCCAGAAGAAATTCAACAGCAGATTGTTCGAGAGACTTTCCATCTAGTCCTCAAGCGGGATGACAACATCTGTAACTTCT
TGGAGGGTGGAAGTTTGATTGGTGGCTCTGACTACAAACTGATCTACCGGCACTATGCTACCCTCTACTTTGTATTTTGTGTGGATTCCT
CAGAGAGTGAACTTGGAATCTTGGACCTCATCCAGGTTTTTGTGGAAACTCTGGATAAGTGTTTCGAAAATGTGTGTGAATTGGATTTGA
TCTTCCATATGGATAAGGTTGCTTCAGGTGAATGCAATGAAGACACTGAAGTTTACAACATCACCCTGTGTACTGGGGATGAACTCACTC
TAATGGGGCAGGCAGAAATCCTTTATGCAAAGACATTCAAGGAAAAGTCACGACTCAACACAATCTTCAAAAAGATTGGGAAGCTCAATT
CCATCAGCAAGCTGGGAAAAGGCAAAATGCCGTGCCTCATTTGTATGAATCACCGGACCAACGAAAGCATTAGCCTTCCATTCCAGTGCA
AGGGCAGATTTAGCACCCGAAGTCCCCTGGAACTTCAGATGCAAGAGGGCGAACACACCATCCGCAACATTGTGGAGAAAACCAGGCTTC
CTGTGAATGTGACTGTGCCAAGCCCTCCACCGAGAAACCCATACGACCTCCACTTCATCCGTGAGGGGCACCGCTATAAGTTTGTGAACA
TCCAGACCAAGACGGTGGTGGTTTGCTGTGTGCTGCGGAACAACAAGATCCTCCCCATGCACTTTCCTTTGCACTTGACTGTCCCCAAGT
TCAGCCTCCCAGAACACCTGGTGAAGGGAGAGAGCTGGCCCGAAACCCTGGTCCATCACTGGCTAGGTATCTGCCAAGAACAGTTCGACA
TCGATGAGTATTCACGGGCTGTCCGTGATGTGAAAACCGACTGGAATGAAGAATGCAAGAGCCCCAAGAAGGGTCGGTGCTCTGGCCACA
ACCACGTGCCCAATTCGCTCAGCTACGCCCGCGATGAGCTCACCCAGTCCTTCCACCGACTCTCGGTCTGTGTGTATGGCAACAATCTCC
ATGGCAACAGTGAGGTGAACCTTCATGGTTGCAGGGACCTGGGGGGAGATTGGGCTCCCTTTCCTCATGACATCCTGCCCTATCAGGACT
CTGGAGATAGTGGGAGCGACTACCTTTTCCCAGAAGCTAGTGAAGAATCAGCAGGCATCCCGGGAAAGTCAGAACTTCCCTACGAAGAGC
TGTGGCTGGAGGAAGGCAAGCCCAGCCATCAGCCTCTCACTCGCTCTCTGAGCGAGAAGAACAGATGTGATCAGTTTAGAGGTTCTGTCC
GATCCAAATGTGCGACTTCTCCTCTTCCCATCCCTGGGACTCTGGGAGCAGCAGTGAAGTCTTCAGATACTGCCCTACCTCCACCTCCAG
TGCCTCCCAAATCTGAAGCCGTCAGAGAAGAATGCCGGCTCCTGAACGCCCCACCTGTTCCACCCCGAAGCGCAAAGCCTTTGTCCACCA
GTCCCTCCATCCCTCCTCGCACAGTCAAGCCAGCGCGGCAACAGACTCGCTCTCCCAGCCCCACCTTGTCCTACTATTCTTCAGGGCTAC
ACAACATCAGCGTCACTAAAACTGACACAAATCCTTCTGAAAGCACTCCTGTTTCCTGCTATCCATGTAACCGAGTGAAAACTGATTCTG
TGGACCTGAAATCCCCGTTTGGAAGTCCTTCTGCTGAAGCTGTGTCCTCTCGGCTCTCATGGCCTAACCATTATTCAGGAGCATCAGAAA
GCCAGACCAGGAGTGACTTCCTGCTGGATCCAAGCAGGAGTTATAGTTACCCTAGACAAAAGACGCCAGGCACACCAAAGAGAAACTGCC
CAGCACCTTTTGATTTTGATGGCTGTGAGCTCCTGGCCAGCCCCACTAGCCCAGTCACTGCAGAATTCAGTAGCAGCGTCTCTGGTTGTC
CCAAGTCAGCCAGCTACTCTCTGGAGAGCACAGATGTGAAATCTCTTGCAGCTGGTGTGACAAAGCAGAGTACGTCATGCCCTGCCTTAC
CCCCCAGGGCTCCAAAACTAGTGGAAGAGAAGGTCGCCTCCGAAACATCTCCTTTGCCTCTGAAAATTGATGGTGCTGAGGAAGACCCCA
AGTCTGGGTCACCAGATCTCTCGGAGGACCAGTATTTTGTTAAAAAGGGCATGCAGGACATCTTCTCTGCCTCCTACCCTTTCTCATCTC
CGCTCCATCTCCAGCTGGCCCCCAGATCCTGTGGCGACGGTTCCCCATGGCAGCCACCTGCTGACCTATCAGGACTCTCTATAGAGGAAG
TGTCCAAGTCACTACGGTTCATTGGTTTGTCCGAAGATGTCATATCATTCTTTGTTACTGAAAAGATTGATGGGAACCTGCTTGTTCAGC
TAACGGAAGAAATCCTCTCAGAGGATTTCAAATTGAGCAAATTGCAGGTGAAGAAGATAATGCAATTCATTAATGGCTGGAGGCCCAAAA
TATAGCCAAATAACCCCCGGCCAGCATGGAACAAAACTGATCAATGCGTGTGCTAGAAGGGGTGGGCTGGGACACAATTTCATGTTTTTG
CACTAAAAACCTTCTCTGTAAATAGGGATAAGAGAAACTCTTACTATGCAGATTACGTTTTTGAATGGTGAACAGGCTATTTTGTACATC
AATAAAAATGCTGTACAGAACACTTGGAGGTGTGCCTTGTACGTCACTCAACAAACACTCAGCAGCTGCTAAAAGAAAAAAAGGCATGTG
CAGAGAAATCATTCTTACCCAAGTAGGTTTATGTGAGAAGGTATGATATTTATTACAAAATAGCCAAAGCTGGAAGACATAAAAATCTTT

>5302_5302_5_AP3S2-GAREM_AP3S2_chr15_90414707_ENST00000560940_GAREM_chr18_29868166_ENST00000269209_length(amino acids)=868AA_BP=123
MREPWLAKMIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSES
ELGILDLIQVFVETLDKCFENVCELDLIFHMDKVASGECNEDTEVYNITLCTGDELTLMGQAEILYAKTFKEKSRLNTIFKKIGKLNSIS
KLGKGKMPCLICMNHRTNESISLPFQCKGRFSTRSPLELQMQEGEHTIRNIVEKTRLPVNVTVPSPPPRNPYDLHFIREGHRYKFVNIQT
KTVVVCCVLRNNKILPMHFPLHLTVPKFSLPEHLVKGESWPETLVHHWLGICQEQFDIDEYSRAVRDVKTDWNEECKSPKKGRCSGHNHV
PNSLSYARDELTQSFHRLSVCVYGNNLHGNSEVNLHGCRDLGGDWAPFPHDILPYQDSGDSGSDYLFPEASEESAGIPGKSELPYEELWL
EEGKPSHQPLTRSLSEKNRCDQFRGSVRSKCATSPLPIPGTLGAAVKSSDTALPPPPVPPKSEAVREECRLLNAPPVPPRSAKPLSTSPS
IPPRTVKPARQQTRSPSPTLSYYSSGLHNISVTKTDTNPSESTPVSCYPCNRVKTDSVDLKSPFGSPSAEAVSSRLSWPNHYSGASESQT
RSDFLLDPSRSYSYPRQKTPGTPKRNCPAPFDFDGCELLASPTSPVTAEFSSSVSGCPKSASYSLESTDVKSLAAGVTKQSTSCPALPPR
APKLVEEKVASETSPLPLKIDGAEEDPKSGSPDLSEDQYFVKKGMQDIFSASYPFSSPLHLQLAPRSCGDGSPWQPPADLSGLSIEEVSK

--------------------------------------------------------------
>5302_5302_6_AP3S2-GAREM_AP3S2_chr15_90414707_ENST00000560940_GAREM_chr18_29868166_ENST00000399218_length(transcript)=6961nt_BP=377nt
AGCCGGTGCTGAGAGAACCGTGGCTGGCAAAGATGATTCAGGCGATTCTGGTTTTCAACAACCATGGGAAGCCACGGCTAGTCCGCTTCT
ACCAGCGTTTCCCAGAAGAAATTCAACAGCAGATTGTTCGAGAGACTTTCCATCTAGTCCTCAAGCGGGATGACAACATCTGTAACTTCT
TGGAGGGTGGAAGTTTGATTGGTGGCTCTGACTACAAACTGATCTACCGGCACTATGCTACCCTCTACTTTGTATTTTGTGTGGATTCCT
CAGAGAGTGAACTTGGAATCTTGGACCTCATCCAGGTTTTTGTGGAAACTCTGGATAAGTGTTTCGAAAATGTGTGTGAATTGGATTTGA
TCTTCCATATGGATAAGGTTGCTTCAGGTGAATGCAATGAAGACACTGAAGTTTACAACATCACCCTGTGTACTGGGGATGAACTCACTC
TAATGGGGCAGGCAGAAATCCTTTATGCAAAGACATTCAAGGAAAAGTCACGACTCAACACAATCTTCAAAAAGATTGGGAAGCTCAATT
CCATCAGCAAGCTGGGAAAAGGCAAAATGCCGTGCCTCATTTGTATGAATCACCGGACCAACGAAAGCATTAGCCTTCCATTCCAGTGCA
AGGGCAGATTTAGCACCCGAAGTCCCCTGGAACTTCAGATGCAAGAGGGCGAACACACCATCCGCAACATTGTGGAGAAAACCAGGCTTC
CTGTGAATGTGACTGTGCCAAGCCCTCCACCGAGAAACCCATACGACCTCCACTTCATCCGTGAGGGGCACCGCTATAAGTTTGTGAACA
TCCAGACCAAGACGGTGGTGGTTTGCTGTGTGCTGCGGAACAACAAGATCCTCCCCATGCACTTTCCTTTGCACTTGACTGTCCCCAAGT
TCAGCCTCCCAGAACACCTGGTGAAGGGAGAGAGCTGGCCCGAAACCCTGGTCCATCACTGGCTAGGTATCTGCCAAGAACAGTTCGACA
TCGATGAGTATTCACGGGCTGTCCGTGATGTGAAAACCGACTGGAATGAAGAATGCAAGAGCCCCAAGAAGGGTCGGTGCTCTGGCCACA
ACCACGTGCCCAATTCGCTCAGCTACGCCCGCGATGAGCTCACCCAGTCCTTCCACCGACTCTCGGTCTGTGTGTATGGCAACAATCTCC
ATGGCAACAGTGAGGTGAACCTTCATGGTTGCAGGGACCTGGGGGGAGATTGGGCTCCCTTTCCTCATGACATCCTGCCCTATCAGGACT
CTGGAGATAGTGGGAGCGACTACCTTTTCCCAGAAGCTAGTGAAGAATCAGCAGGCATCCCGGGAAAGTCAGAACTTCCCTACGAAGAGC
TGTGGCTGGAGGAAGGCAAGCCCAGCCATCAGCCTCTCACTCGCTCTCTGAGCGAGAAGAACAGATGTGATCAGTTTAGAGGTTCTGTCC
GATCCAAATGTGCGACTTCTCCTCTTCCCATCCCTGGGACTCTGGGAGCAGCAGTGAAGTCTTCAGATACTGCCCTACCTCCACCTCCAG
TGCCTCCCAAATCTGAAGCCGTCAGAGAAGAATGCCGGCTCCTGAACGCCCCACCTGTTCCACCCCGAAGCGCAAAGCCTTTGTCCACCA
GTCCCTCCATCCCTCCTCGCACAGTCAAGCCAGCGCGGCAACAGACTCGCTCTCCCAGCCCCACCTTGTCCTACTATTCTTCAGGGCTAC
ACAACATCGTCACTAAAACTGACACAAATCCTTCTGAAAGCACTCCTGTTTCCTGCTATCCATGTAACCGAGTGAAAACTGATTCTGTGG
ACCTGAAATCCCCGTTTGGAAGTCCTTCTGCTGAAGCTGTGTCCTCTCGGCTCTCATGGCCTAACCATTATTCAGGAGCATCAGAAAGCC
AGACCAGGAGTGACTTCCTGCTGGATCCAAGCAGGAGTTATAGTTACCCTAGACAAAAGACGCCAGGCACACCAAAGAGAAACTGCCCAG
CACCTTTTGATTTTGATGGCTGTGAGCTCCTGGCCAGCCCCACTAGCCCAGTCACTGCAGAATTCAGTAGCAGCGTCTCTGGTTGTCCCA
AGTCAGCCAGCTACTCTCTGGAGAGCACAGATGTGAAATCTCTTGCAGCTGGTGTGACAAAGCAGAGTACGTCATGCCCTGCCTTACCCC
CCAGGGCTCCAAAACTAGTGGAAGAGAAGGTCGCCTCCGAAACATCTCCTTTGCCTCTGAAAATTGATGGTGCTGAGGAAGACCCCAAGT
CTGGGTCACCAGATCTCTCGGAGGACCAGTATTTTGTTAAAAAGGGCATGCAGGACATCTTCTCTGCCTCCTACCCTTTCTCATCTCCGC
TCCATCTCCAGCTGGCCCCCAGATCCTGTGGCGACGGTTCCCCATGGCAGCCACCTGCTGACCTATCAGGACTCTCTATAGAGGAAGTGT
CCAAGTCACTACGGTTCATTGGTTTGTCCGAAGATGTCATATCATTCTTTGTTACTGAAAAGATTGATGGGAACCTGCTTGTTCAGCTAA
CGGAAGAAATCCTCTCAGAGGATTTCAAATTGAGCAAATTGCAGGTGAAGAAGATAATGCAATTCATTAATGGCTGGAGGCCCAAAATAT
AGCCAAATAACCCCCGGCCAGCATGGAACAAAACTGATCAATGCGTGTGCTAGAAGGGGTGGGCTGGGACACAATTTCATGTTTTTGCAC
TAAAAACCTTCTCTGTAAATAGGGATAAGAGAAACTCTTACTATGCAGATTACGTTTTTGAATGGTGAACAGGCTATTTTGTACATCAAT
AAAAATGCTGTACAGAACACTTGGAGGTGTGCCTTGTACGTCACTCAACAAACACTCAGCAGCTGCTAAAAGAAAAAAAGGCATGTGCAG
AGAAATCATTCTTACCCAAGTAGGTTTATGTGAGAAGGTATGATATTTATTACAAAATAGCCAAAGCTGGAAGACATAAAAATCTTTAAA
AAAAAAAAAAAAACACTTTTGAACAAGTCCCTTCTTTCAGGAGGGTTGACTTTAGACAATTAACTGTGTTCTGTGCTCTGTCATTCAGAT
TGCTTCTTGCTAATTGTTTTACTCTTGTGCCTGAAAATGTTAGTGATACGAATTGACACTTTAATGTTGTATGCTTGGTGGGGATCTTTT
TATCACAAGGCATTTTCCAAGAGTCATATGTTGATAAAGGGATATATGTTGTCCTTAGAAATCACACAAATCATGACCACAATAATTTAT
CTGTAACTGCTGCTAATTTTATTGAGCAGAGAAAAAAGAATATACATATATAAACATGTATAGGTGCATACACAATACACCCGGATATGT
TTTACACATAATTTTGATTCTGATATTTTAGATAACATCTGTTCACTTTTAAACAATCTGTTGAGGTTTTGGGACTGTTATCTACATTGA
TTCTCTTAGGAATAGTGGACAGAATGACTCCAAAGATTCTCAGAACCCTGTCTCTTGAAGCTCAATCTTATTTGGGTTCATCACTGAAAA
CTTAGAACAAATCAGTAAAGAATCCTGTATTGAAGAATTAAGTTTGAGTTTAAGCCCACTCACCGCAGGGCTGGTTTTTGCATGTAATAC
TCCCATGATGTCTGGGGAAATGACAGTTTCTGTTGAATTATAATTCTCCGGTTTAAGGGTCTCCTTCCCCTGGTGTCTGATGGTGAGAGG
TCTGAAGAGCATTTGTCAGAGTACATTAGGCATTCTCAACCTACTTCATGCTTTACGAGAGCTGAGAAATCAGACGCACCGGCCTTTATT
ATTATATATGCTACATCTGTTGAGTATTTTTAAAATACCAATAAGAGGACTTGTTTATTTCATAAACCACTTCTTCCCTCTCTTTCAAAG
AAAATACATTATTACCATACTTTTACATTAGTCTGAGAATTTTTGCTAAATATGATTAAGTATTCCAAAATATAATGGCGTCATTATTCT
TGACTTTTTTAGAGAATATACATCTTAAGACTGTATTAGTTCTCAGAGCAAGGCATCATCTACTCCCCTGCACCTGAGAGTCTGGCCCCA
GATTCCAGATGTGCGGACAGCCCATGACCGAGGTGCACACAGTGCCCTCTTGAATAGGAAGGTCAGCCAGTGAGGCGGCAGCATAACTTG
CAGGATGGACTTATATCTTACCATCTCTTCCTGCTACCAAAATAAAAAAATAAATTGAAAGACAAGACCCACCAGTCTAGTTTTGTAGAC
CTGTGAAATGTGTCTTTATTTCTTGGCATTAGAAGAAAGATATTTTTAATCCATATCGTGGTTTTAGAGTTGAAGTGAATTGATACCCAA
TTTTCCATCTTAGATCTCCTTTATCAAAAAAAAAAGCATTTTTTTTCTCCTAACGTGTCTCCCAAAATGTAAATACTATAGGCAAAAAGA
GTACCCTGTAAAATTCTCACACTGGAGCACCTCTTCAAAAGTCACAGATAACTCAATGAGGAAGTGCTGGTACTGCACTCACAGGACATG
AGACCTATGAAGCTTTCGTGTTTTGAAAGCATCCTTCTGTGTGAGGGGGACTGCCTCCCTTAGTAAAGTAAACCTCTCAGAACTTCTTTT
TAAAATAAAAACAGACAAGATGCAGTTACTAAGCTGCAAGTTTTCATTGGCAAACCTAGCTGAATCCGTTTTAAAATACTTAGCACTCGG
ACACAATTCTCAAACTCAGGAAGAAGGAACAGGGTTGGTTTGGGTTTACTATAAAGGTTGCCTCACATAAACAACTGACTCCTTTTAGCG
TTTTTTTTCTTTTTGTAAAAACTTTACACAAAATAGGGTTTTAAATTCTTTTTGCTTGTTTTGGACTTGGTGTATTTTTGTCAAGTTTAT
ATTGATTGGCAACGCAGAGACTCCTTGAGGGCAGGGACTGTGGCCTTTGATTCACTTATGCTACAGTCTAGTATCACTACAGTGCTGAGT
AAAAGACACAGCCCCTGCCCTCTTGGAGATCATATTGTTTATATTTGAAATCTCAGTTGCTAAGAGTATGTATGTGTGAGTAAGAAAGAC
GTGAAGTCCTATGGGCAGCTGGGTATATGGAGAATTACGTGTGTCCTGTCTTTAAAACGTCAGCCTCTATTAAGGGGTACAGAACACCCC
AAGATCACTAAAACTTGGAATGTGTTGGAGGCAGAAAGTATCTCTCTCATTGCCTAGTGTTGTTGTTTTTTTGTTTTTTGTTTTTTGTTT
TTTTTACTGACCTGGAATTCTTTTAATTGTAATAAATATCTTCTGTCACAAATAAATGCCACAAATAAATGAAATTGCCATTCCTAAGCT
GAGCACCTGTCTGTGAAGGACCTTGGTGTCCTGACTGGACAGAGCATTCATAGCTCCAAGAGAATCATGACAAGATATGCAAAGCAGGGA
TAATAAGGAGAAAGCCCTTCCCTTTCGAGAAGCCCTTCCCTTTCACAGCCCTTCCCTGCGATTCTGCAGTGAAAAGTGATGCCCAGAGAT
CCACACACAGAACCCTTCTAACCAGCCAGGTCAAGACTTATCATCTTATCTCCTCTGGCAGGTCCCCTGTAATCAAAAGAGAGGAAGTGT
CTATCTAAACAAGACCCTTTTGGGTCCTTAGATTCATGGCAAAAATCATCATGGCCCCCATCAGAAAAGAAAATCAGCAATAAACCAAGC
CAAGCAACTAAAATGTATAATGTGGACCTGACTCATGTTGGGAGGCAGAATTCAGACACTCACAGATCAATCTTGCAAGTTTTCTCTTCT
TTAAGTTGAGCTGCTCAACTTTATGAACTGTGAAATTTACTTACATTCTTTCAACCCACATATATCATTGCAGTTTATGAAGTTGCAGTG
AACTGCCCATTCAGCTAAATTGCAGTGTTTATTCTTGTCTCATGTCGAAATACAACAATCTTATGGGAAATATTATGACAGTCCGTTCCA
ACTGTTCTCAGACACATGCATAAACAGTCTCTGCTCACATTCCACAGCCACCTGCATGTTATCCATACAGCTCCCTGAGAAGTCCAGGGA
TGGGAGGTGGGGTGTGGAAGGATGGAGGGTCCTTCATTTTCTAAACACTTTGTATAAGTCACTACTCATCGTGCCTAGCAAGTATAAGAT
TAACATTTTGAATAACAAACTGGAAAACAAATAATCCTTCAAAGAACCTAGCGAACTGTTCAAAGGAAATTTTAATTTCAGTCTACCAGA
AAAGTTAAATCTGTTGTTGGACGTAGGGGGCTTTCAGAAACATGCCTCTTATATCAATTTCCACTATCTTTCAAGTTACCTAAAGGCACC
AGGCTGCTTGAGCAAGAAGAATAAAAGGCCTAGAGTGCAAATTATGTGAAGTAGAGTTTTTAGATTGTGGGATTGTAATAATACGGGATT
CTCATGGTTACATCATGTTAAATCACACTGTTCAGTCTTTAAAACTTGGTGTTTTAAAATTTGTCTCATTGTGATAGCCAGAAACAAGGA
ATAAACGTGATTTCAGTTTAAACTATATACAAATATCTTCTGTAATTTTGCTGCTCTAATTTTTAGGCTATAAATTTTGTAATAGAGCTT
ATCAGATCGCAAATTTCCTTTGTTTACAATCTCATGTAGTAGGGCTCAGATAATTTCTTAGCTATAAACCTTTTCTCCCACTCTCATATT
GTTTCATTTAAAATATTTAAGCTAAGCCTAAAAATTGAAATCAGTTAAGAATTTGGAGAGTTTATCTTAAATGGAAATGGTGTATTCTTT
TCAAAGAATTTTGTAACCATCTTTACAGTTTCTTTGCTTGGAAAACTTGGGTTGTTAACTACCAGTTAACAATGGCATTACTTTCCAAAA
CGTTATCTAATGGGCCCAATGTGTACCTCAAGATAAACACAGTATGTTATGTCTAAAAATTTCCTTGTCTGTTGATTTAAATGGTTCTGA

>5302_5302_6_AP3S2-GAREM_AP3S2_chr15_90414707_ENST00000560940_GAREM_chr18_29868166_ENST00000399218_length(amino acids)=867AA_BP=123
MREPWLAKMIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSES
ELGILDLIQVFVETLDKCFENVCELDLIFHMDKVASGECNEDTEVYNITLCTGDELTLMGQAEILYAKTFKEKSRLNTIFKKIGKLNSIS
KLGKGKMPCLICMNHRTNESISLPFQCKGRFSTRSPLELQMQEGEHTIRNIVEKTRLPVNVTVPSPPPRNPYDLHFIREGHRYKFVNIQT
KTVVVCCVLRNNKILPMHFPLHLTVPKFSLPEHLVKGESWPETLVHHWLGICQEQFDIDEYSRAVRDVKTDWNEECKSPKKGRCSGHNHV
PNSLSYARDELTQSFHRLSVCVYGNNLHGNSEVNLHGCRDLGGDWAPFPHDILPYQDSGDSGSDYLFPEASEESAGIPGKSELPYEELWL
EEGKPSHQPLTRSLSEKNRCDQFRGSVRSKCATSPLPIPGTLGAAVKSSDTALPPPPVPPKSEAVREECRLLNAPPVPPRSAKPLSTSPS
IPPRTVKPARQQTRSPSPTLSYYSSGLHNIVTKTDTNPSESTPVSCYPCNRVKTDSVDLKSPFGSPSAEAVSSRLSWPNHYSGASESQTR
SDFLLDPSRSYSYPRQKTPGTPKRNCPAPFDFDGCELLASPTSPVTAEFSSSVSGCPKSASYSLESTDVKSLAAGVTKQSTSCPALPPRA
PKLVEEKVASETSPLPLKIDGAEEDPKSGSPDLSEDQYFVKKGMQDIFSASYPFSSPLHLQLAPRSCGDGSPWQPPADLSGLSIEEVSKS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for AP3S2-GAREM

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for AP3S2-GAREM

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for AP3S2-GAREM

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source