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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:MET-CFTR (FusionGDB2 ID:53021) |
Fusion Gene Summary for MET-CFTR |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MET-CFTR | Fusion gene ID: 53021 | Hgene | Tgene | Gene symbol | MET | CFTR | Gene ID | 8731 | 1080 |
| Gene name | RNA guanine-7 methyltransferase | CF transmembrane conductance regulator | |
| Synonyms | CMT1|CMT1c|MET|Met|RG7MT1|cm1p|hCMT1|hMet | ABC35|ABCC7|CF|CFTR/MRP|MRP7|TNR-CFTR|dJ760C5.1 | |
| Cytomap | 18p11.21 | 7q31.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mRNA cap guanine-N7 methyltransferaseRNA (guanine-7-) methyltransferasehcm1pmRNA (guanine-7-)methyltransferasemRNA (guanine-N(7)-)-methyltransferasemRNA cap methyltransferase | cystic fibrosis transmembrane conductance regulatorcAMP-dependent chloride channelchannel conductance-controlling ATPasecystic fibrosis transmembrane conductance regulatingcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-f | |
| Modification date | 20200329 | 20200329 | |
| UniProtAcc | . | P13569 | |
| Ensembl transtripts involved in fusion gene | ENST00000318493, ENST00000397752, ENST00000436117, ENST00000495962, ENST00000539704, | ENST00000608965, ENST00000003084, ENST00000454343, | |
| Fusion gene scores | * DoF score | 11 X 10 X 9=990 | 13 X 15 X 10=1950 |
| # samples | 16 | 13 | |
| ** MAII score | log2(16/990*10)=-2.62935662007961 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/1950*10)=-3.90689059560852 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MET [Title/Abstract] AND CFTR [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | MET(116340338)-CFTR(117355812), # samples:1 MET(116312631)-CFTR(117355812), # samples:1 MET(116312631)-CFTR(117352395), # samples:1 MET(116340338)-CFTR(117282492), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MET | GO:0006370 | 7-methylguanosine mRNA capping | 27422871 |
| Tgene | CFTR | GO:0015701 | bicarbonate transport | 15010471|19019741 |
| Tgene | CFTR | GO:0034976 | response to endoplasmic reticulum stress | 21884936|28067262 |
| Tgene | CFTR | GO:1902476 | chloride transmembrane transport | 11524016|11707463|19019741 |
| Tgene | CFTR | GO:1902943 | positive regulation of voltage-gated chloride channel activity | 22006324 |
| Tgene | CFTR | GO:1904322 | cellular response to forskolin | 15010471|19621064 |
| Fusion gene breakpoints across MET (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across CFTR (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LGG | TCGA-HT-A61C | MET | chr7 | 116312631 | + | CFTR | chr7 | 117352395 | + |
| ChimerDB4 | LGG | TCGA-HT-A61C | MET | chr7 | 116312631 | + | CFTR | chr7 | 117355812 | + |
| ChimerDB4 | LGG | TCGA-HT-A61C | MET | chr7 | 116340338 | + | CFTR | chr7 | 117355812 | + |
| ChimerDB4 | STAD | TCGA-D7-8576-01A | MET | chr7 | 116340338 | + | CFTR | chr7 | 117282492 | + |
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Fusion Gene ORF analysis for MET-CFTR |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000318493 | ENST00000608965 | MET | chr7 | 116340338 | + | CFTR | chr7 | 117355812 | + |
| 5CDS-3UTR | ENST00000397752 | ENST00000608965 | MET | chr7 | 116340338 | + | CFTR | chr7 | 117355812 | + |
| 5CDS-3UTR | ENST00000436117 | ENST00000608965 | MET | chr7 | 116340338 | + | CFTR | chr7 | 117355812 | + |
| 5CDS-intron | ENST00000318493 | ENST00000003084 | MET | chr7 | 116340338 | + | CFTR | chr7 | 117355812 | + |
| 5CDS-intron | ENST00000318493 | ENST00000454343 | MET | chr7 | 116340338 | + | CFTR | chr7 | 117355812 | + |
| 5CDS-intron | ENST00000318493 | ENST00000608965 | MET | chr7 | 116340338 | + | CFTR | chr7 | 117282492 | + |
| 5CDS-intron | ENST00000397752 | ENST00000003084 | MET | chr7 | 116340338 | + | CFTR | chr7 | 117355812 | + |
| 5CDS-intron | ENST00000397752 | ENST00000454343 | MET | chr7 | 116340338 | + | CFTR | chr7 | 117355812 | + |
| 5CDS-intron | ENST00000397752 | ENST00000608965 | MET | chr7 | 116340338 | + | CFTR | chr7 | 117282492 | + |
| 5CDS-intron | ENST00000436117 | ENST00000003084 | MET | chr7 | 116340338 | + | CFTR | chr7 | 117355812 | + |
| 5CDS-intron | ENST00000436117 | ENST00000454343 | MET | chr7 | 116340338 | + | CFTR | chr7 | 117355812 | + |
| 5CDS-intron | ENST00000436117 | ENST00000608965 | MET | chr7 | 116340338 | + | CFTR | chr7 | 117282492 | + |
| 5UTR-3UTR | ENST00000318493 | ENST00000608965 | MET | chr7 | 116312631 | + | CFTR | chr7 | 117355812 | + |
| 5UTR-3UTR | ENST00000397752 | ENST00000608965 | MET | chr7 | 116312631 | + | CFTR | chr7 | 117355812 | + |
| 5UTR-intron | ENST00000318493 | ENST00000003084 | MET | chr7 | 116312631 | + | CFTR | chr7 | 117352395 | + |
| 5UTR-intron | ENST00000318493 | ENST00000003084 | MET | chr7 | 116312631 | + | CFTR | chr7 | 117355812 | + |
| 5UTR-intron | ENST00000318493 | ENST00000454343 | MET | chr7 | 116312631 | + | CFTR | chr7 | 117352395 | + |
| 5UTR-intron | ENST00000318493 | ENST00000454343 | MET | chr7 | 116312631 | + | CFTR | chr7 | 117355812 | + |
| 5UTR-intron | ENST00000318493 | ENST00000608965 | MET | chr7 | 116312631 | + | CFTR | chr7 | 117352395 | + |
| 5UTR-intron | ENST00000397752 | ENST00000003084 | MET | chr7 | 116312631 | + | CFTR | chr7 | 117352395 | + |
| 5UTR-intron | ENST00000397752 | ENST00000003084 | MET | chr7 | 116312631 | + | CFTR | chr7 | 117355812 | + |
| 5UTR-intron | ENST00000397752 | ENST00000454343 | MET | chr7 | 116312631 | + | CFTR | chr7 | 117352395 | + |
| 5UTR-intron | ENST00000397752 | ENST00000454343 | MET | chr7 | 116312631 | + | CFTR | chr7 | 117355812 | + |
| 5UTR-intron | ENST00000397752 | ENST00000608965 | MET | chr7 | 116312631 | + | CFTR | chr7 | 117352395 | + |
| In-frame | ENST00000318493 | ENST00000003084 | MET | chr7 | 116340338 | + | CFTR | chr7 | 117282492 | + |
| In-frame | ENST00000318493 | ENST00000454343 | MET | chr7 | 116340338 | + | CFTR | chr7 | 117282492 | + |
| In-frame | ENST00000397752 | ENST00000003084 | MET | chr7 | 116340338 | + | CFTR | chr7 | 117282492 | + |
| In-frame | ENST00000397752 | ENST00000454343 | MET | chr7 | 116340338 | + | CFTR | chr7 | 117282492 | + |
| In-frame | ENST00000436117 | ENST00000003084 | MET | chr7 | 116340338 | + | CFTR | chr7 | 117282492 | + |
| In-frame | ENST00000436117 | ENST00000454343 | MET | chr7 | 116340338 | + | CFTR | chr7 | 117282492 | + |
| intron-3CDS | ENST00000495962 | ENST00000003084 | MET | chr7 | 116340338 | + | CFTR | chr7 | 117282492 | + |
| intron-3CDS | ENST00000495962 | ENST00000454343 | MET | chr7 | 116340338 | + | CFTR | chr7 | 117282492 | + |
| intron-3CDS | ENST00000539704 | ENST00000003084 | MET | chr7 | 116340338 | + | CFTR | chr7 | 117282492 | + |
| intron-3CDS | ENST00000539704 | ENST00000454343 | MET | chr7 | 116340338 | + | CFTR | chr7 | 117282492 | + |
| intron-3UTR | ENST00000436117 | ENST00000608965 | MET | chr7 | 116312631 | + | CFTR | chr7 | 117355812 | + |
| intron-3UTR | ENST00000495962 | ENST00000608965 | MET | chr7 | 116312631 | + | CFTR | chr7 | 117355812 | + |
| intron-3UTR | ENST00000495962 | ENST00000608965 | MET | chr7 | 116340338 | + | CFTR | chr7 | 117355812 | + |
| intron-3UTR | ENST00000539704 | ENST00000608965 | MET | chr7 | 116312631 | + | CFTR | chr7 | 117355812 | + |
| intron-3UTR | ENST00000539704 | ENST00000608965 | MET | chr7 | 116340338 | + | CFTR | chr7 | 117355812 | + |
| intron-intron | ENST00000436117 | ENST00000003084 | MET | chr7 | 116312631 | + | CFTR | chr7 | 117352395 | + |
| intron-intron | ENST00000436117 | ENST00000003084 | MET | chr7 | 116312631 | + | CFTR | chr7 | 117355812 | + |
| intron-intron | ENST00000436117 | ENST00000454343 | MET | chr7 | 116312631 | + | CFTR | chr7 | 117352395 | + |
| intron-intron | ENST00000436117 | ENST00000454343 | MET | chr7 | 116312631 | + | CFTR | chr7 | 117355812 | + |
| intron-intron | ENST00000436117 | ENST00000608965 | MET | chr7 | 116312631 | + | CFTR | chr7 | 117352395 | + |
| intron-intron | ENST00000495962 | ENST00000003084 | MET | chr7 | 116312631 | + | CFTR | chr7 | 117352395 | + |
| intron-intron | ENST00000495962 | ENST00000003084 | MET | chr7 | 116312631 | + | CFTR | chr7 | 117355812 | + |
| intron-intron | ENST00000495962 | ENST00000003084 | MET | chr7 | 116340338 | + | CFTR | chr7 | 117355812 | + |
| intron-intron | ENST00000495962 | ENST00000454343 | MET | chr7 | 116312631 | + | CFTR | chr7 | 117352395 | + |
| intron-intron | ENST00000495962 | ENST00000454343 | MET | chr7 | 116312631 | + | CFTR | chr7 | 117355812 | + |
| intron-intron | ENST00000495962 | ENST00000454343 | MET | chr7 | 116340338 | + | CFTR | chr7 | 117355812 | + |
| intron-intron | ENST00000495962 | ENST00000608965 | MET | chr7 | 116312631 | + | CFTR | chr7 | 117352395 | + |
| intron-intron | ENST00000495962 | ENST00000608965 | MET | chr7 | 116340338 | + | CFTR | chr7 | 117282492 | + |
| intron-intron | ENST00000539704 | ENST00000003084 | MET | chr7 | 116312631 | + | CFTR | chr7 | 117352395 | + |
| intron-intron | ENST00000539704 | ENST00000003084 | MET | chr7 | 116312631 | + | CFTR | chr7 | 117355812 | + |
| intron-intron | ENST00000539704 | ENST00000003084 | MET | chr7 | 116340338 | + | CFTR | chr7 | 117355812 | + |
| intron-intron | ENST00000539704 | ENST00000454343 | MET | chr7 | 116312631 | + | CFTR | chr7 | 117352395 | + |
| intron-intron | ENST00000539704 | ENST00000454343 | MET | chr7 | 116312631 | + | CFTR | chr7 | 117355812 | + |
| intron-intron | ENST00000539704 | ENST00000454343 | MET | chr7 | 116340338 | + | CFTR | chr7 | 117355812 | + |
| intron-intron | ENST00000539704 | ENST00000608965 | MET | chr7 | 116312631 | + | CFTR | chr7 | 117352395 | + |
| intron-intron | ENST00000539704 | ENST00000608965 | MET | chr7 | 116340338 | + | CFTR | chr7 | 117282492 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000397752 | MET | chr7 | 116340338 | + | ENST00000003084 | CFTR | chr7 | 117282492 | + | 3679 | 1400 | 200 | 2125 | 641 |
| ENST00000397752 | MET | chr7 | 116340338 | + | ENST00000454343 | CFTR | chr7 | 117282492 | + | 3683 | 1400 | 200 | 2125 | 641 |
| ENST00000318493 | MET | chr7 | 116340338 | + | ENST00000003084 | CFTR | chr7 | 117282492 | + | 3666 | 1387 | 187 | 2112 | 641 |
| ENST00000318493 | MET | chr7 | 116340338 | + | ENST00000454343 | CFTR | chr7 | 117282492 | + | 3670 | 1387 | 187 | 2112 | 641 |
| ENST00000436117 | MET | chr7 | 116340338 | + | ENST00000003084 | CFTR | chr7 | 117282492 | + | 3479 | 1200 | 0 | 1925 | 641 |
| ENST00000436117 | MET | chr7 | 116340338 | + | ENST00000454343 | CFTR | chr7 | 117282492 | + | 3483 | 1200 | 0 | 1925 | 641 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000397752 | ENST00000003084 | MET | chr7 | 116340338 | + | CFTR | chr7 | 117282492 | + | 0.00037538 | 0.9996246 |
| ENST00000397752 | ENST00000454343 | MET | chr7 | 116340338 | + | CFTR | chr7 | 117282492 | + | 0.000371027 | 0.9996289 |
| ENST00000318493 | ENST00000003084 | MET | chr7 | 116340338 | + | CFTR | chr7 | 117282492 | + | 0.000377918 | 0.9996221 |
| ENST00000318493 | ENST00000454343 | MET | chr7 | 116340338 | + | CFTR | chr7 | 117282492 | + | 0.000373517 | 0.9996265 |
| ENST00000436117 | ENST00000003084 | MET | chr7 | 116340338 | + | CFTR | chr7 | 117282492 | + | 0.000363054 | 0.9996369 |
| ENST00000436117 | ENST00000454343 | MET | chr7 | 116340338 | + | CFTR | chr7 | 117282492 | + | 0.000357233 | 0.9996427 |
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Fusion Genomic Features for MET-CFTR |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for MET-CFTR |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:116340338/chr7:117355812) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | CFTR |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis (PubMed:26823428). Mediates the transport of chloride ions across the cell membrane (PubMed:10792060, PubMed:11524016, PubMed:11707463, PubMed:12519745, PubMed:15010471, PubMed:12588899, PubMed:17036051, PubMed:19398555, PubMed:19621064, PubMed:22178883, PubMed:25330774, PubMed:1712898, PubMed:8910473, PubMed:9804160, PubMed:12529365, PubMed:17182731, PubMed:26846474, PubMed:28087700). Channel activity is coupled to ATP hydrolysis (PubMed:8910473). The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration (PubMed:15010471, PubMed:19019741). Exerts its function also by modulating the activity of other ion channels and transporters (PubMed:12403779, PubMed:22178883, PubMed:22121115, PubMed:27941075). Plays an important role in airway fluid homeostasis (PubMed:16645176, PubMed:19621064, PubMed:26823428). Contributes to the regulation of the pH and the ion content of the airway surface fluid layer and thereby plays an important role in defense against pathogens (PubMed:14668433, PubMed:16645176, PubMed:26823428). Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex (PubMed:17434346, PubMed:27941075, PubMed:17182731). Inhibits the activity of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731). Inhibits the activity of the ENaC channel containing subunits SCNN1D, SCNN1B and SCNN1G, but not of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:27941075). May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7 (PubMed:12403779). Can inhibit the chloride channel activity of ANO1 (PubMed:22178883). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (PubMed:19923167, PubMed:27714810). {ECO:0000269|PubMed:10792060, ECO:0000269|PubMed:11524016, ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:12403779, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:12529365, ECO:0000269|PubMed:12588899, ECO:0000269|PubMed:14668433, ECO:0000269|PubMed:15010471, ECO:0000269|PubMed:16645176, ECO:0000269|PubMed:17036051, ECO:0000269|PubMed:1712898, ECO:0000269|PubMed:17182731, ECO:0000269|PubMed:19019741, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:19621064, ECO:0000269|PubMed:22178883, ECO:0000269|PubMed:25330774, ECO:0000269|PubMed:26627831, ECO:0000269|PubMed:26823428, ECO:0000269|PubMed:26846474, ECO:0000269|PubMed:27714810, ECO:0000269|PubMed:27941075, ECO:0000269|PubMed:28087700, ECO:0000269|PubMed:8910473, ECO:0000269|PubMed:9804160, ECO:0000305|PubMed:19923167}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000454343 | 20 | 26 | 1210_1443 | 1178 | 1420.0 | Domain | ABC transporter 2 | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000003084 | 21 | 27 | 1244_1251 | 1239 | 1481.0 | Nucleotide binding | ATP 2 | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000454343 | 20 | 26 | 1244_1251 | 1178 | 1420.0 | Nucleotide binding | ATP 2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MET | chr7:116340338 | chr7:117282492 | ENST00000318493 | + | 2 | 21 | 1078_1345 | 400 | 1409.0 | Domain | Protein kinase |
| Hgene | MET | chr7:116340338 | chr7:117282492 | ENST00000318493 | + | 2 | 21 | 27_515 | 400 | 1409.0 | Domain | Sema |
| Hgene | MET | chr7:116340338 | chr7:117282492 | ENST00000318493 | + | 2 | 21 | 563_655 | 400 | 1409.0 | Domain | Note=IPT/TIG 1 |
| Hgene | MET | chr7:116340338 | chr7:117282492 | ENST00000318493 | + | 2 | 21 | 657_739 | 400 | 1409.0 | Domain | Note=IPT/TIG 2 |
| Hgene | MET | chr7:116340338 | chr7:117282492 | ENST00000318493 | + | 2 | 21 | 742_836 | 400 | 1409.0 | Domain | Note=IPT/TIG 3 |
| Hgene | MET | chr7:116340338 | chr7:117282492 | ENST00000397752 | + | 2 | 21 | 1078_1345 | 400 | 1391.0 | Domain | Protein kinase |
| Hgene | MET | chr7:116340338 | chr7:117282492 | ENST00000397752 | + | 2 | 21 | 27_515 | 400 | 1391.0 | Domain | Sema |
| Hgene | MET | chr7:116340338 | chr7:117282492 | ENST00000397752 | + | 2 | 21 | 563_655 | 400 | 1391.0 | Domain | Note=IPT/TIG 1 |
| Hgene | MET | chr7:116340338 | chr7:117282492 | ENST00000397752 | + | 2 | 21 | 657_739 | 400 | 1391.0 | Domain | Note=IPT/TIG 2 |
| Hgene | MET | chr7:116340338 | chr7:117282492 | ENST00000397752 | + | 2 | 21 | 742_836 | 400 | 1391.0 | Domain | Note=IPT/TIG 3 |
| Hgene | MET | chr7:116340338 | chr7:117282492 | ENST00000436117 | + | 1 | 9 | 1078_1345 | 400 | 765.0 | Domain | Protein kinase |
| Hgene | MET | chr7:116340338 | chr7:117282492 | ENST00000436117 | + | 1 | 9 | 27_515 | 400 | 765.0 | Domain | Sema |
| Hgene | MET | chr7:116340338 | chr7:117282492 | ENST00000436117 | + | 1 | 9 | 563_655 | 400 | 765.0 | Domain | Note=IPT/TIG 1 |
| Hgene | MET | chr7:116340338 | chr7:117282492 | ENST00000436117 | + | 1 | 9 | 657_739 | 400 | 765.0 | Domain | Note=IPT/TIG 2 |
| Hgene | MET | chr7:116340338 | chr7:117282492 | ENST00000436117 | + | 1 | 9 | 742_836 | 400 | 765.0 | Domain | Note=IPT/TIG 3 |
| Hgene | MET | chr7:116340338 | chr7:117282492 | ENST00000318493 | + | 2 | 21 | 1084_1092 | 400 | 1409.0 | Nucleotide binding | ATP |
| Hgene | MET | chr7:116340338 | chr7:117282492 | ENST00000397752 | + | 2 | 21 | 1084_1092 | 400 | 1391.0 | Nucleotide binding | ATP |
| Hgene | MET | chr7:116340338 | chr7:117282492 | ENST00000436117 | + | 1 | 9 | 1084_1092 | 400 | 765.0 | Nucleotide binding | ATP |
| Hgene | MET | chr7:116340338 | chr7:117282492 | ENST00000318493 | + | 2 | 21 | 25_932 | 400 | 1409.0 | Topological domain | Extracellular |
| Hgene | MET | chr7:116340338 | chr7:117282492 | ENST00000318493 | + | 2 | 21 | 956_1390 | 400 | 1409.0 | Topological domain | Cytoplasmic |
| Hgene | MET | chr7:116340338 | chr7:117282492 | ENST00000397752 | + | 2 | 21 | 25_932 | 400 | 1391.0 | Topological domain | Extracellular |
| Hgene | MET | chr7:116340338 | chr7:117282492 | ENST00000397752 | + | 2 | 21 | 956_1390 | 400 | 1391.0 | Topological domain | Cytoplasmic |
| Hgene | MET | chr7:116340338 | chr7:117282492 | ENST00000436117 | + | 1 | 9 | 25_932 | 400 | 765.0 | Topological domain | Extracellular |
| Hgene | MET | chr7:116340338 | chr7:117282492 | ENST00000436117 | + | 1 | 9 | 956_1390 | 400 | 765.0 | Topological domain | Cytoplasmic |
| Hgene | MET | chr7:116340338 | chr7:117282492 | ENST00000318493 | + | 2 | 21 | 933_955 | 400 | 1409.0 | Transmembrane | Helical |
| Hgene | MET | chr7:116340338 | chr7:117282492 | ENST00000397752 | + | 2 | 21 | 933_955 | 400 | 1391.0 | Transmembrane | Helical |
| Hgene | MET | chr7:116340338 | chr7:117282492 | ENST00000436117 | + | 1 | 9 | 933_955 | 400 | 765.0 | Transmembrane | Helical |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000003084 | 21 | 27 | 1210_1443 | 1239 | 1481.0 | Domain | ABC transporter 2 | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000003084 | 21 | 27 | 423_646 | 1239 | 1481.0 | Domain | ABC transporter 1 | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000003084 | 21 | 27 | 81_365 | 1239 | 1481.0 | Domain | ABC transmembrane type-1 1 | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000003084 | 21 | 27 | 859_1155 | 1239 | 1481.0 | Domain | ABC transmembrane type-1 2 | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000454343 | 20 | 26 | 423_646 | 1178 | 1420.0 | Domain | ABC transporter 1 | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000454343 | 20 | 26 | 81_365 | 1178 | 1420.0 | Domain | ABC transmembrane type-1 1 | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000454343 | 20 | 26 | 859_1155 | 1178 | 1420.0 | Domain | ABC transmembrane type-1 2 | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000003084 | 21 | 27 | 458_465 | 1239 | 1481.0 | Nucleotide binding | ATP 1 | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000454343 | 20 | 26 | 458_465 | 1178 | 1420.0 | Nucleotide binding | ATP 1 | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000003084 | 21 | 27 | 654_831 | 1239 | 1481.0 | Region | Intrinsically disordered R region | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000454343 | 20 | 26 | 654_831 | 1178 | 1420.0 | Region | Intrinsically disordered R region | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000003084 | 21 | 27 | 1012_1013 | 1239 | 1481.0 | Topological domain | Extracellular | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000003084 | 21 | 27 | 1035_1095 | 1239 | 1481.0 | Topological domain | Cytoplasmic | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000003084 | 21 | 27 | 1117_1130 | 1239 | 1481.0 | Topological domain | Extracellular | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000003084 | 21 | 27 | 1152_1480 | 1239 | 1481.0 | Topological domain | Cytoplasmic | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000003084 | 21 | 27 | 147_195 | 1239 | 1481.0 | Topological domain | Cytoplasmic | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000003084 | 21 | 27 | 1_77 | 1239 | 1481.0 | Topological domain | Cytoplasmic | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000003084 | 21 | 27 | 217_222 | 1239 | 1481.0 | Topological domain | Extracellular | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000003084 | 21 | 27 | 244_298 | 1239 | 1481.0 | Topological domain | Cytoplasmic | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000003084 | 21 | 27 | 320_339 | 1239 | 1481.0 | Topological domain | Extracellular | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000003084 | 21 | 27 | 359_858 | 1239 | 1481.0 | Topological domain | Cytoplasmic | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000003084 | 21 | 27 | 880_918 | 1239 | 1481.0 | Topological domain | Extracellular | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000003084 | 21 | 27 | 940_990 | 1239 | 1481.0 | Topological domain | Cytoplasmic | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000003084 | 21 | 27 | 99_122 | 1239 | 1481.0 | Topological domain | Extracellular | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000454343 | 20 | 26 | 1012_1013 | 1178 | 1420.0 | Topological domain | Extracellular | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000454343 | 20 | 26 | 1035_1095 | 1178 | 1420.0 | Topological domain | Cytoplasmic | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000454343 | 20 | 26 | 1117_1130 | 1178 | 1420.0 | Topological domain | Extracellular | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000454343 | 20 | 26 | 1152_1480 | 1178 | 1420.0 | Topological domain | Cytoplasmic | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000454343 | 20 | 26 | 147_195 | 1178 | 1420.0 | Topological domain | Cytoplasmic | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000454343 | 20 | 26 | 1_77 | 1178 | 1420.0 | Topological domain | Cytoplasmic | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000454343 | 20 | 26 | 217_222 | 1178 | 1420.0 | Topological domain | Extracellular | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000454343 | 20 | 26 | 244_298 | 1178 | 1420.0 | Topological domain | Cytoplasmic | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000454343 | 20 | 26 | 320_339 | 1178 | 1420.0 | Topological domain | Extracellular | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000454343 | 20 | 26 | 359_858 | 1178 | 1420.0 | Topological domain | Cytoplasmic | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000454343 | 20 | 26 | 880_918 | 1178 | 1420.0 | Topological domain | Extracellular | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000454343 | 20 | 26 | 940_990 | 1178 | 1420.0 | Topological domain | Cytoplasmic | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000454343 | 20 | 26 | 99_122 | 1178 | 1420.0 | Topological domain | Extracellular | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000003084 | 21 | 27 | 1014_1034 | 1239 | 1481.0 | Transmembrane | Helical%3B Name%3D10 | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000003084 | 21 | 27 | 1096_1116 | 1239 | 1481.0 | Transmembrane | Helical%3B Name%3D11 | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000003084 | 21 | 27 | 1131_1151 | 1239 | 1481.0 | Transmembrane | Helical%3B Name%3D12 | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000003084 | 21 | 27 | 123_146 | 1239 | 1481.0 | Transmembrane | Helical%3B Name%3D2 | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000003084 | 21 | 27 | 196_216 | 1239 | 1481.0 | Transmembrane | Helical%3B Name%3D3 | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000003084 | 21 | 27 | 223_243 | 1239 | 1481.0 | Transmembrane | Helical%3B Name%3D4 | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000003084 | 21 | 27 | 299_319 | 1239 | 1481.0 | Transmembrane | Helical%3B Name%3D5 | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000003084 | 21 | 27 | 340_358 | 1239 | 1481.0 | Transmembrane | Helical%3B Name%3D6 | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000003084 | 21 | 27 | 78_98 | 1239 | 1481.0 | Transmembrane | Helical%3B Name%3D1 | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000003084 | 21 | 27 | 859_879 | 1239 | 1481.0 | Transmembrane | Helical%3B Name%3D7 | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000003084 | 21 | 27 | 919_939 | 1239 | 1481.0 | Transmembrane | Discontinuously helical%3B Name%3D8 | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000003084 | 21 | 27 | 991_1011 | 1239 | 1481.0 | Transmembrane | Helical%3B Name%3D9 | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000454343 | 20 | 26 | 1014_1034 | 1178 | 1420.0 | Transmembrane | Helical%3B Name%3D10 | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000454343 | 20 | 26 | 1096_1116 | 1178 | 1420.0 | Transmembrane | Helical%3B Name%3D11 | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000454343 | 20 | 26 | 1131_1151 | 1178 | 1420.0 | Transmembrane | Helical%3B Name%3D12 | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000454343 | 20 | 26 | 123_146 | 1178 | 1420.0 | Transmembrane | Helical%3B Name%3D2 | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000454343 | 20 | 26 | 196_216 | 1178 | 1420.0 | Transmembrane | Helical%3B Name%3D3 | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000454343 | 20 | 26 | 223_243 | 1178 | 1420.0 | Transmembrane | Helical%3B Name%3D4 | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000454343 | 20 | 26 | 299_319 | 1178 | 1420.0 | Transmembrane | Helical%3B Name%3D5 | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000454343 | 20 | 26 | 340_358 | 1178 | 1420.0 | Transmembrane | Helical%3B Name%3D6 | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000454343 | 20 | 26 | 78_98 | 1178 | 1420.0 | Transmembrane | Helical%3B Name%3D1 | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000454343 | 20 | 26 | 859_879 | 1178 | 1420.0 | Transmembrane | Helical%3B Name%3D7 | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000454343 | 20 | 26 | 919_939 | 1178 | 1420.0 | Transmembrane | Discontinuously helical%3B Name%3D8 | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000454343 | 20 | 26 | 991_1011 | 1178 | 1420.0 | Transmembrane | Helical%3B Name%3D9 |
Top |
Fusion Gene Sequence for MET-CFTR |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >53021_53021_1_MET-CFTR_MET_chr7_116340338_ENST00000318493_CFTR_chr7_117282492_ENST00000003084_length(transcript)=3666nt_BP=1387nt GCCCTCGCCGCCCGCGGCGCCCCGAGCGCTTTGTGAGCAGATGCGGAGCCGAGTGGAGGGCGCGAGCCAGATGCGGGGCGACAGCTGACT TGCTGAGAGGAGGCGGGGAGGCGCGGAGCGCGCGTGTGGTCCTTGCGCCGCTGACTTCTCCACTGGTTCCTGGGCACCGAAAGATAAACC TCTCATAATGAAGGCCCCCGCTGTGCTTGCACCTGGCATCCTCGTGCTCCTGTTTACCTTGGTGCAGAGGAGCAATGGGGAGTGTAAAGA GGCACTAGCAAAGTCCGAGATGAATGTGAATATGAAGTATCAGCTTCCCAACTTCACCGCGGAAACACCCATCCAGAATGTCATTCTACA TGAGCATCACATTTTCCTTGGTGCCACTAACTACATTTATGTTTTAAATGAGGAAGACCTTCAGAAGGTTGCTGAGTACAAGACTGGGCC TGTGCTGGAACACCCAGATTGTTTCCCATGTCAGGACTGCAGCAGCAAAGCCAATTTATCAGGAGGTGTTTGGAAAGATAACATCAACAT GGCTCTAGTTGTCGACACCTACTATGATGATCAACTCATTAGCTGTGGCAGCGTCAACAGAGGGACCTGCCAGCGACATGTCTTTCCCCA CAATCATACTGCTGACATACAGTCGGAGGTTCACTGCATATTCTCCCCACAGATAGAAGAGCCCAGCCAGTGTCCTGACTGTGTGGTGAG CGCCCTGGGAGCCAAAGTCCTTTCATCTGTAAAGGACCGGTTCATCAACTTCTTTGTAGGCAATACCATAAATTCTTCTTATTTCCCAGA TCATCCATTGCATTCGATATCAGTGAGAAGGCTAAAGGAAACGAAAGATGGTTTTATGTTTTTGACGGACCAGTCCTACATTGATGTTTT ACCTGAGTTCAGAGATTCTTACCCCATTAAGTATGTCCATGCCTTTGAAAGCAACAATTTTATTTACTTCTTGACGGTCCAAAGGGAAAC TCTAGATGCTCAGACTTTTCACACAAGAATAATCAGGTTCTGTTCCATAAACTCTGGATTGCATTCCTACATGGAAATGCCTCTGGAGTG TATTCTCACAGAAAAGAGAAAAAAGAGATCCACAAAGAAGGAAGTGTTTAATATACTTCAGGCTGCGTATGTCAGCAAGCCTGGGGCCCA GCTTGCTAGACAAATAGGAGCCAGCCTGAATGATGACATTCTTTTCGGGGTGTTCGCACAAAGCAAGCCAGATTCTGCCGAACCAATGGA TCGATCTGCCATGTGTGCATTCCCTATCAAATATGTCAACGACTTCTTCAACAAGATCGTCAACAAAAACAATGTGAGATGTCTCCAGCA TTTTTACGGACCCAATCATGAGCACTGCTTTAATAGGGTGGGCCTCTTGGGAAGAACTGGATCAGGGAAGAGTACTTTGTTATCAGCTTT TTTGAGACTACTGAACACTGAAGGAGAAATCCAGATCGATGGTGTGTCTTGGGATTCAATAACTTTGCAACAGTGGAGGAAAGCCTTTGG AGTGATACCACAGAAAGTATTTATTTTTTCTGGAACATTTAGAAAAAACTTGGATCCCTATGAACAGTGGAGTGATCAAGAAATATGGAA AGTTGCAGATGAGGTTGGGCTCAGATCTGTGATAGAACAGTTTCCTGGGAAGCTTGACTTTGTCCTTGTGGATGGGGGCTGTGTCCTAAG CCATGGCCACAAGCAGTTGATGTGCTTGGCTAGATCTGTTCTCAGTAAGGCGAAGATCTTGCTGCTTGATGAACCCAGTGCTCATTTGGA TCCAGTAACATACCAAATAATTAGAAGAACTCTAAAACAAGCATTTGCTGATTGCACAGTAATTCTCTGTGAACACAGGATAGAAGCAAT GCTGGAATGCCAACAATTTTTGGTCATAGAAGAGAACAAAGTGCGGCAGTACGATTCCATCCAGAAACTGCTGAACGAGAGGAGCCTCTT CCGGCAAGCCATCAGCCCCTCCGACAGGGTGAAGCTCTTTCCCCACCGGAACTCAAGCAAGTGCAAGTCTAAGCCCCAGATTGCTGCTCT GAAAGAGGAGACAGAAGAAGAGGTGCAAGATACAAGGCTTTAGAGAGCAGCATAAATGTTGACATGGGACATTTGCTCATGGAATTGGAG CTCGTGGGACAGTCACCTCATGGAATTGGAGCTCGTGGAACAGTTACCTCTGCCTCAGAAAACAAGGATGAATTAAGTTTTTTTTTAAAA AAGAAACATTTGGTAAGGGGAATTGAGGACACTGATATGGGTCTTGATAAATGGCTTCCTGGCAATAGTCAAATTGTGTGAAAGGTACTT CAAATCCTTGAAGATTTACCACTTGTGTTTTGCAAGCCAGATTTTCCTGAAAACCCTTGCCATGTGCTAGTAATTGGAAAGGCAGCTCTA AATGTCAATCAGCCTAGTTGATCAGCTTATTGTCTAGTGAAACTCGTTAATTTGTAGTGTTGGAGAAGAACTGAAATCATACTTCTTAGG GTTATGATTAAGTAATGATAACTGGAAACTTCAGCGGTTTATATAAGCTTGTATTCCTTTTTCTCTCCTCTCCCCATGATGTTTAGAAAC ACAACTATATTGTTTGCTAAGCATTCCAACTATCTCATTTCCAAGCAAGTATTAGAATACCACAGGAACCACAAGACTGCACATCAAAAT ATGCCCCATTCAACATCTAGTGAGCAGTCAGGAAAGAGAACTTCCAGATCCTGGAAATCAGGGTTAGTATTGTCCAGGTCTACCAAAAAT CTCAATATTTCAGATAATCACAATACATCCCTTACCTGGGAAAGGGCTGTTATAATCTTTCACAGGGGACAGGATGGTTCCCTTGATGAA GAAGTTGATATGCCTTTTCCCAACTCCAGAAAGTGACAAGCTCACAGACCTTTGAACTAGAGTTTAGCTGGAAAAGTATGTTAGTGCAAA TTGTCACAGGACAGCCCTTCTTTCCACAGAAGCTCCAGGTAGAGGGTGTGTAAGTAGATAGGCCATGGGCACTGTGGGTAGACACACATG AAGTCCAAGCATTTAGATGTATAGGTTGATGGTGGTATGTTTTCAGGCTAGATGTATGTACTTCATGCTGTCTACACTAAGAGAGAATGA GAGACACACTGAAGAAGCACCAATCATGAATTAGTTTTATATGCTTCTGTTTTATAATTTTGTGAAGCAAAATTTTTTCTCTAGGAAATA TTTATTTTAATAATGTTTCAAACATATATAACAATGCTGTATTTTAAAAGAATGATTATGAATTACATTTGTATAAAATAATTTTTATAT TTGAAATATTGACTTTTTATGGCACTAGTATTTCTATGAAATATTATGTTAAAACTGGGACAGGGGAGAACCTAGGGTGATATTAACCAG GGGCCATGAATCACCTTTTGGTCTGGAGGGAAGCCTTGGGGCTGATGCAGTTGTTGCCCACAGCTGTATGATTCCCAGCCAGCACAGCCT CTTAGATGCAGTTCTGAAGAAGATGGTACCACCAGTCTGACTGTTTCCATCAAGGGTACACTGCCTTCTCAACTCCAAACTGACTCTTAA >53021_53021_1_MET-CFTR_MET_chr7_116340338_ENST00000318493_CFTR_chr7_117282492_ENST00000003084_length(amino acids)=641AA_BP=0 MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVL EHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSAL GAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLD AQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRS AMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVI PQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPV TYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKPQIAALKE -------------------------------------------------------------- >53021_53021_2_MET-CFTR_MET_chr7_116340338_ENST00000318493_CFTR_chr7_117282492_ENST00000454343_length(transcript)=3670nt_BP=1387nt GCCCTCGCCGCCCGCGGCGCCCCGAGCGCTTTGTGAGCAGATGCGGAGCCGAGTGGAGGGCGCGAGCCAGATGCGGGGCGACAGCTGACT TGCTGAGAGGAGGCGGGGAGGCGCGGAGCGCGCGTGTGGTCCTTGCGCCGCTGACTTCTCCACTGGTTCCTGGGCACCGAAAGATAAACC TCTCATAATGAAGGCCCCCGCTGTGCTTGCACCTGGCATCCTCGTGCTCCTGTTTACCTTGGTGCAGAGGAGCAATGGGGAGTGTAAAGA GGCACTAGCAAAGTCCGAGATGAATGTGAATATGAAGTATCAGCTTCCCAACTTCACCGCGGAAACACCCATCCAGAATGTCATTCTACA TGAGCATCACATTTTCCTTGGTGCCACTAACTACATTTATGTTTTAAATGAGGAAGACCTTCAGAAGGTTGCTGAGTACAAGACTGGGCC TGTGCTGGAACACCCAGATTGTTTCCCATGTCAGGACTGCAGCAGCAAAGCCAATTTATCAGGAGGTGTTTGGAAAGATAACATCAACAT GGCTCTAGTTGTCGACACCTACTATGATGATCAACTCATTAGCTGTGGCAGCGTCAACAGAGGGACCTGCCAGCGACATGTCTTTCCCCA CAATCATACTGCTGACATACAGTCGGAGGTTCACTGCATATTCTCCCCACAGATAGAAGAGCCCAGCCAGTGTCCTGACTGTGTGGTGAG CGCCCTGGGAGCCAAAGTCCTTTCATCTGTAAAGGACCGGTTCATCAACTTCTTTGTAGGCAATACCATAAATTCTTCTTATTTCCCAGA TCATCCATTGCATTCGATATCAGTGAGAAGGCTAAAGGAAACGAAAGATGGTTTTATGTTTTTGACGGACCAGTCCTACATTGATGTTTT ACCTGAGTTCAGAGATTCTTACCCCATTAAGTATGTCCATGCCTTTGAAAGCAACAATTTTATTTACTTCTTGACGGTCCAAAGGGAAAC TCTAGATGCTCAGACTTTTCACACAAGAATAATCAGGTTCTGTTCCATAAACTCTGGATTGCATTCCTACATGGAAATGCCTCTGGAGTG TATTCTCACAGAAAAGAGAAAAAAGAGATCCACAAAGAAGGAAGTGTTTAATATACTTCAGGCTGCGTATGTCAGCAAGCCTGGGGCCCA GCTTGCTAGACAAATAGGAGCCAGCCTGAATGATGACATTCTTTTCGGGGTGTTCGCACAAAGCAAGCCAGATTCTGCCGAACCAATGGA TCGATCTGCCATGTGTGCATTCCCTATCAAATATGTCAACGACTTCTTCAACAAGATCGTCAACAAAAACAATGTGAGATGTCTCCAGCA TTTTTACGGACCCAATCATGAGCACTGCTTTAATAGGGTGGGCCTCTTGGGAAGAACTGGATCAGGGAAGAGTACTTTGTTATCAGCTTT TTTGAGACTACTGAACACTGAAGGAGAAATCCAGATCGATGGTGTGTCTTGGGATTCAATAACTTTGCAACAGTGGAGGAAAGCCTTTGG AGTGATACCACAGAAAGTATTTATTTTTTCTGGAACATTTAGAAAAAACTTGGATCCCTATGAACAGTGGAGTGATCAAGAAATATGGAA AGTTGCAGATGAGGTTGGGCTCAGATCTGTGATAGAACAGTTTCCTGGGAAGCTTGACTTTGTCCTTGTGGATGGGGGCTGTGTCCTAAG CCATGGCCACAAGCAGTTGATGTGCTTGGCTAGATCTGTTCTCAGTAAGGCGAAGATCTTGCTGCTTGATGAACCCAGTGCTCATTTGGA TCCAGTAACATACCAAATAATTAGAAGAACTCTAAAACAAGCATTTGCTGATTGCACAGTAATTCTCTGTGAACACAGGATAGAAGCAAT GCTGGAATGCCAACAATTTTTGGTCATAGAAGAGAACAAAGTGCGGCAGTACGATTCCATCCAGAAACTGCTGAACGAGAGGAGCCTCTT CCGGCAAGCCATCAGCCCCTCCGACAGGGTGAAGCTCTTTCCCCACCGGAACTCAAGCAAGTGCAAGTCTAAGCCCCAGATTGCTGCTCT GAAAGAGGAGACAGAAGAAGAGGTGCAAGATACAAGGCTTTAGAGAGCAGCATAAATGTTGACATGGGACATTTGCTCATGGAATTGGAG CTCGTGGGACAGTCACCTCATGGAATTGGAGCTCGTGGAACAGTTACCTCTGCCTCAGAAAACAAGGATGAATTAAGTTTTTTTTTAAAA AAGAAACATTTGGTAAGGGGAATTGAGGACACTGATATGGGTCTTGATAAATGGCTTCCTGGCAATAGTCAAATTGTGTGAAAGGTACTT CAAATCCTTGAAGATTTACCACTTGTGTTTTGCAAGCCAGATTTTCCTGAAAACCCTTGCCATGTGCTAGTAATTGGAAAGGCAGCTCTA AATGTCAATCAGCCTAGTTGATCAGCTTATTGTCTAGTGAAACTCGTTAATTTGTAGTGTTGGAGAAGAACTGAAATCATACTTCTTAGG GTTATGATTAAGTAATGATAACTGGAAACTTCAGCGGTTTATATAAGCTTGTATTCCTTTTTCTCTCCTCTCCCCATGATGTTTAGAAAC ACAACTATATTGTTTGCTAAGCATTCCAACTATCTCATTTCCAAGCAAGTATTAGAATACCACAGGAACCACAAGACTGCACATCAAAAT ATGCCCCATTCAACATCTAGTGAGCAGTCAGGAAAGAGAACTTCCAGATCCTGGAAATCAGGGTTAGTATTGTCCAGGTCTACCAAAAAT CTCAATATTTCAGATAATCACAATACATCCCTTACCTGGGAAAGGGCTGTTATAATCTTTCACAGGGGACAGGATGGTTCCCTTGATGAA GAAGTTGATATGCCTTTTCCCAACTCCAGAAAGTGACAAGCTCACAGACCTTTGAACTAGAGTTTAGCTGGAAAAGTATGTTAGTGCAAA TTGTCACAGGACAGCCCTTCTTTCCACAGAAGCTCCAGGTAGAGGGTGTGTAAGTAGATAGGCCATGGGCACTGTGGGTAGACACACATG AAGTCCAAGCATTTAGATGTATAGGTTGATGGTGGTATGTTTTCAGGCTAGATGTATGTACTTCATGCTGTCTACACTAAGAGAGAATGA GAGACACACTGAAGAAGCACCAATCATGAATTAGTTTTATATGCTTCTGTTTTATAATTTTGTGAAGCAAAATTTTTTCTCTAGGAAATA TTTATTTTAATAATGTTTCAAACATATATAACAATGCTGTATTTTAAAAGAATGATTATGAATTACATTTGTATAAAATAATTTTTATAT TTGAAATATTGACTTTTTATGGCACTAGTATTTCTATGAAATATTATGTTAAAACTGGGACAGGGGAGAACCTAGGGTGATATTAACCAG GGGCCATGAATCACCTTTTGGTCTGGAGGGAAGCCTTGGGGCTGATGCAGTTGTTGCCCACAGCTGTATGATTCCCAGCCAGCACAGCCT CTTAGATGCAGTTCTGAAGAAGATGGTACCACCAGTCTGACTGTTTCCATCAAGGGTACACTGCCTTCTCAACTCCAAACTGACTCTTAA >53021_53021_2_MET-CFTR_MET_chr7_116340338_ENST00000318493_CFTR_chr7_117282492_ENST00000454343_length(amino acids)=641AA_BP=0 MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVL EHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSAL GAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLD AQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRS AMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVI PQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPV TYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKPQIAALKE -------------------------------------------------------------- >53021_53021_3_MET-CFTR_MET_chr7_116340338_ENST00000397752_CFTR_chr7_117282492_ENST00000003084_length(transcript)=3679nt_BP=1400nt AGGTGACCCGGAGGCCCTCGCCGCCCGCGGCGCCCCGAGCGCTTTGTGAGCAGATGCGGAGCCGAGTGGAGGGCGCGAGCCAGATGCGGG GCGACAGCTGACTTGCTGAGAGGAGGCGGGGAGGCGCGGAGCGCGCGTGTGGTCCTTGCGCCGCTGACTTCTCCACTGGTTCCTGGGCAC CGAAAGATAAACCTCTCATAATGAAGGCCCCCGCTGTGCTTGCACCTGGCATCCTCGTGCTCCTGTTTACCTTGGTGCAGAGGAGCAATG GGGAGTGTAAAGAGGCACTAGCAAAGTCCGAGATGAATGTGAATATGAAGTATCAGCTTCCCAACTTCACCGCGGAAACACCCATCCAGA ATGTCATTCTACATGAGCATCACATTTTCCTTGGTGCCACTAACTACATTTATGTTTTAAATGAGGAAGACCTTCAGAAGGTTGCTGAGT ACAAGACTGGGCCTGTGCTGGAACACCCAGATTGTTTCCCATGTCAGGACTGCAGCAGCAAAGCCAATTTATCAGGAGGTGTTTGGAAAG ATAACATCAACATGGCTCTAGTTGTCGACACCTACTATGATGATCAACTCATTAGCTGTGGCAGCGTCAACAGAGGGACCTGCCAGCGAC ATGTCTTTCCCCACAATCATACTGCTGACATACAGTCGGAGGTTCACTGCATATTCTCCCCACAGATAGAAGAGCCCAGCCAGTGTCCTG ACTGTGTGGTGAGCGCCCTGGGAGCCAAAGTCCTTTCATCTGTAAAGGACCGGTTCATCAACTTCTTTGTAGGCAATACCATAAATTCTT CTTATTTCCCAGATCATCCATTGCATTCGATATCAGTGAGAAGGCTAAAGGAAACGAAAGATGGTTTTATGTTTTTGACGGACCAGTCCT ACATTGATGTTTTACCTGAGTTCAGAGATTCTTACCCCATTAAGTATGTCCATGCCTTTGAAAGCAACAATTTTATTTACTTCTTGACGG TCCAAAGGGAAACTCTAGATGCTCAGACTTTTCACACAAGAATAATCAGGTTCTGTTCCATAAACTCTGGATTGCATTCCTACATGGAAA TGCCTCTGGAGTGTATTCTCACAGAAAAGAGAAAAAAGAGATCCACAAAGAAGGAAGTGTTTAATATACTTCAGGCTGCGTATGTCAGCA AGCCTGGGGCCCAGCTTGCTAGACAAATAGGAGCCAGCCTGAATGATGACATTCTTTTCGGGGTGTTCGCACAAAGCAAGCCAGATTCTG CCGAACCAATGGATCGATCTGCCATGTGTGCATTCCCTATCAAATATGTCAACGACTTCTTCAACAAGATCGTCAACAAAAACAATGTGA GATGTCTCCAGCATTTTTACGGACCCAATCATGAGCACTGCTTTAATAGGGTGGGCCTCTTGGGAAGAACTGGATCAGGGAAGAGTACTT TGTTATCAGCTTTTTTGAGACTACTGAACACTGAAGGAGAAATCCAGATCGATGGTGTGTCTTGGGATTCAATAACTTTGCAACAGTGGA GGAAAGCCTTTGGAGTGATACCACAGAAAGTATTTATTTTTTCTGGAACATTTAGAAAAAACTTGGATCCCTATGAACAGTGGAGTGATC AAGAAATATGGAAAGTTGCAGATGAGGTTGGGCTCAGATCTGTGATAGAACAGTTTCCTGGGAAGCTTGACTTTGTCCTTGTGGATGGGG GCTGTGTCCTAAGCCATGGCCACAAGCAGTTGATGTGCTTGGCTAGATCTGTTCTCAGTAAGGCGAAGATCTTGCTGCTTGATGAACCCA GTGCTCATTTGGATCCAGTAACATACCAAATAATTAGAAGAACTCTAAAACAAGCATTTGCTGATTGCACAGTAATTCTCTGTGAACACA GGATAGAAGCAATGCTGGAATGCCAACAATTTTTGGTCATAGAAGAGAACAAAGTGCGGCAGTACGATTCCATCCAGAAACTGCTGAACG AGAGGAGCCTCTTCCGGCAAGCCATCAGCCCCTCCGACAGGGTGAAGCTCTTTCCCCACCGGAACTCAAGCAAGTGCAAGTCTAAGCCCC AGATTGCTGCTCTGAAAGAGGAGACAGAAGAAGAGGTGCAAGATACAAGGCTTTAGAGAGCAGCATAAATGTTGACATGGGACATTTGCT CATGGAATTGGAGCTCGTGGGACAGTCACCTCATGGAATTGGAGCTCGTGGAACAGTTACCTCTGCCTCAGAAAACAAGGATGAATTAAG TTTTTTTTTAAAAAAGAAACATTTGGTAAGGGGAATTGAGGACACTGATATGGGTCTTGATAAATGGCTTCCTGGCAATAGTCAAATTGT GTGAAAGGTACTTCAAATCCTTGAAGATTTACCACTTGTGTTTTGCAAGCCAGATTTTCCTGAAAACCCTTGCCATGTGCTAGTAATTGG AAAGGCAGCTCTAAATGTCAATCAGCCTAGTTGATCAGCTTATTGTCTAGTGAAACTCGTTAATTTGTAGTGTTGGAGAAGAACTGAAAT CATACTTCTTAGGGTTATGATTAAGTAATGATAACTGGAAACTTCAGCGGTTTATATAAGCTTGTATTCCTTTTTCTCTCCTCTCCCCAT GATGTTTAGAAACACAACTATATTGTTTGCTAAGCATTCCAACTATCTCATTTCCAAGCAAGTATTAGAATACCACAGGAACCACAAGAC TGCACATCAAAATATGCCCCATTCAACATCTAGTGAGCAGTCAGGAAAGAGAACTTCCAGATCCTGGAAATCAGGGTTAGTATTGTCCAG GTCTACCAAAAATCTCAATATTTCAGATAATCACAATACATCCCTTACCTGGGAAAGGGCTGTTATAATCTTTCACAGGGGACAGGATGG TTCCCTTGATGAAGAAGTTGATATGCCTTTTCCCAACTCCAGAAAGTGACAAGCTCACAGACCTTTGAACTAGAGTTTAGCTGGAAAAGT ATGTTAGTGCAAATTGTCACAGGACAGCCCTTCTTTCCACAGAAGCTCCAGGTAGAGGGTGTGTAAGTAGATAGGCCATGGGCACTGTGG GTAGACACACATGAAGTCCAAGCATTTAGATGTATAGGTTGATGGTGGTATGTTTTCAGGCTAGATGTATGTACTTCATGCTGTCTACAC TAAGAGAGAATGAGAGACACACTGAAGAAGCACCAATCATGAATTAGTTTTATATGCTTCTGTTTTATAATTTTGTGAAGCAAAATTTTT TCTCTAGGAAATATTTATTTTAATAATGTTTCAAACATATATAACAATGCTGTATTTTAAAAGAATGATTATGAATTACATTTGTATAAA ATAATTTTTATATTTGAAATATTGACTTTTTATGGCACTAGTATTTCTATGAAATATTATGTTAAAACTGGGACAGGGGAGAACCTAGGG TGATATTAACCAGGGGCCATGAATCACCTTTTGGTCTGGAGGGAAGCCTTGGGGCTGATGCAGTTGTTGCCCACAGCTGTATGATTCCCA GCCAGCACAGCCTCTTAGATGCAGTTCTGAAGAAGATGGTACCACCAGTCTGACTGTTTCCATCAAGGGTACACTGCCTTCTCAACTCCA >53021_53021_3_MET-CFTR_MET_chr7_116340338_ENST00000397752_CFTR_chr7_117282492_ENST00000003084_length(amino acids)=641AA_BP=0 MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVL EHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSAL GAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLD AQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRS AMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVI PQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPV TYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKPQIAALKE -------------------------------------------------------------- >53021_53021_4_MET-CFTR_MET_chr7_116340338_ENST00000397752_CFTR_chr7_117282492_ENST00000454343_length(transcript)=3683nt_BP=1400nt AGGTGACCCGGAGGCCCTCGCCGCCCGCGGCGCCCCGAGCGCTTTGTGAGCAGATGCGGAGCCGAGTGGAGGGCGCGAGCCAGATGCGGG GCGACAGCTGACTTGCTGAGAGGAGGCGGGGAGGCGCGGAGCGCGCGTGTGGTCCTTGCGCCGCTGACTTCTCCACTGGTTCCTGGGCAC CGAAAGATAAACCTCTCATAATGAAGGCCCCCGCTGTGCTTGCACCTGGCATCCTCGTGCTCCTGTTTACCTTGGTGCAGAGGAGCAATG GGGAGTGTAAAGAGGCACTAGCAAAGTCCGAGATGAATGTGAATATGAAGTATCAGCTTCCCAACTTCACCGCGGAAACACCCATCCAGA ATGTCATTCTACATGAGCATCACATTTTCCTTGGTGCCACTAACTACATTTATGTTTTAAATGAGGAAGACCTTCAGAAGGTTGCTGAGT ACAAGACTGGGCCTGTGCTGGAACACCCAGATTGTTTCCCATGTCAGGACTGCAGCAGCAAAGCCAATTTATCAGGAGGTGTTTGGAAAG ATAACATCAACATGGCTCTAGTTGTCGACACCTACTATGATGATCAACTCATTAGCTGTGGCAGCGTCAACAGAGGGACCTGCCAGCGAC ATGTCTTTCCCCACAATCATACTGCTGACATACAGTCGGAGGTTCACTGCATATTCTCCCCACAGATAGAAGAGCCCAGCCAGTGTCCTG ACTGTGTGGTGAGCGCCCTGGGAGCCAAAGTCCTTTCATCTGTAAAGGACCGGTTCATCAACTTCTTTGTAGGCAATACCATAAATTCTT CTTATTTCCCAGATCATCCATTGCATTCGATATCAGTGAGAAGGCTAAAGGAAACGAAAGATGGTTTTATGTTTTTGACGGACCAGTCCT ACATTGATGTTTTACCTGAGTTCAGAGATTCTTACCCCATTAAGTATGTCCATGCCTTTGAAAGCAACAATTTTATTTACTTCTTGACGG TCCAAAGGGAAACTCTAGATGCTCAGACTTTTCACACAAGAATAATCAGGTTCTGTTCCATAAACTCTGGATTGCATTCCTACATGGAAA TGCCTCTGGAGTGTATTCTCACAGAAAAGAGAAAAAAGAGATCCACAAAGAAGGAAGTGTTTAATATACTTCAGGCTGCGTATGTCAGCA AGCCTGGGGCCCAGCTTGCTAGACAAATAGGAGCCAGCCTGAATGATGACATTCTTTTCGGGGTGTTCGCACAAAGCAAGCCAGATTCTG CCGAACCAATGGATCGATCTGCCATGTGTGCATTCCCTATCAAATATGTCAACGACTTCTTCAACAAGATCGTCAACAAAAACAATGTGA GATGTCTCCAGCATTTTTACGGACCCAATCATGAGCACTGCTTTAATAGGGTGGGCCTCTTGGGAAGAACTGGATCAGGGAAGAGTACTT TGTTATCAGCTTTTTTGAGACTACTGAACACTGAAGGAGAAATCCAGATCGATGGTGTGTCTTGGGATTCAATAACTTTGCAACAGTGGA GGAAAGCCTTTGGAGTGATACCACAGAAAGTATTTATTTTTTCTGGAACATTTAGAAAAAACTTGGATCCCTATGAACAGTGGAGTGATC AAGAAATATGGAAAGTTGCAGATGAGGTTGGGCTCAGATCTGTGATAGAACAGTTTCCTGGGAAGCTTGACTTTGTCCTTGTGGATGGGG GCTGTGTCCTAAGCCATGGCCACAAGCAGTTGATGTGCTTGGCTAGATCTGTTCTCAGTAAGGCGAAGATCTTGCTGCTTGATGAACCCA GTGCTCATTTGGATCCAGTAACATACCAAATAATTAGAAGAACTCTAAAACAAGCATTTGCTGATTGCACAGTAATTCTCTGTGAACACA GGATAGAAGCAATGCTGGAATGCCAACAATTTTTGGTCATAGAAGAGAACAAAGTGCGGCAGTACGATTCCATCCAGAAACTGCTGAACG AGAGGAGCCTCTTCCGGCAAGCCATCAGCCCCTCCGACAGGGTGAAGCTCTTTCCCCACCGGAACTCAAGCAAGTGCAAGTCTAAGCCCC AGATTGCTGCTCTGAAAGAGGAGACAGAAGAAGAGGTGCAAGATACAAGGCTTTAGAGAGCAGCATAAATGTTGACATGGGACATTTGCT CATGGAATTGGAGCTCGTGGGACAGTCACCTCATGGAATTGGAGCTCGTGGAACAGTTACCTCTGCCTCAGAAAACAAGGATGAATTAAG TTTTTTTTTAAAAAAGAAACATTTGGTAAGGGGAATTGAGGACACTGATATGGGTCTTGATAAATGGCTTCCTGGCAATAGTCAAATTGT GTGAAAGGTACTTCAAATCCTTGAAGATTTACCACTTGTGTTTTGCAAGCCAGATTTTCCTGAAAACCCTTGCCATGTGCTAGTAATTGG AAAGGCAGCTCTAAATGTCAATCAGCCTAGTTGATCAGCTTATTGTCTAGTGAAACTCGTTAATTTGTAGTGTTGGAGAAGAACTGAAAT CATACTTCTTAGGGTTATGATTAAGTAATGATAACTGGAAACTTCAGCGGTTTATATAAGCTTGTATTCCTTTTTCTCTCCTCTCCCCAT GATGTTTAGAAACACAACTATATTGTTTGCTAAGCATTCCAACTATCTCATTTCCAAGCAAGTATTAGAATACCACAGGAACCACAAGAC TGCACATCAAAATATGCCCCATTCAACATCTAGTGAGCAGTCAGGAAAGAGAACTTCCAGATCCTGGAAATCAGGGTTAGTATTGTCCAG GTCTACCAAAAATCTCAATATTTCAGATAATCACAATACATCCCTTACCTGGGAAAGGGCTGTTATAATCTTTCACAGGGGACAGGATGG TTCCCTTGATGAAGAAGTTGATATGCCTTTTCCCAACTCCAGAAAGTGACAAGCTCACAGACCTTTGAACTAGAGTTTAGCTGGAAAAGT ATGTTAGTGCAAATTGTCACAGGACAGCCCTTCTTTCCACAGAAGCTCCAGGTAGAGGGTGTGTAAGTAGATAGGCCATGGGCACTGTGG GTAGACACACATGAAGTCCAAGCATTTAGATGTATAGGTTGATGGTGGTATGTTTTCAGGCTAGATGTATGTACTTCATGCTGTCTACAC TAAGAGAGAATGAGAGACACACTGAAGAAGCACCAATCATGAATTAGTTTTATATGCTTCTGTTTTATAATTTTGTGAAGCAAAATTTTT TCTCTAGGAAATATTTATTTTAATAATGTTTCAAACATATATAACAATGCTGTATTTTAAAAGAATGATTATGAATTACATTTGTATAAA ATAATTTTTATATTTGAAATATTGACTTTTTATGGCACTAGTATTTCTATGAAATATTATGTTAAAACTGGGACAGGGGAGAACCTAGGG TGATATTAACCAGGGGCCATGAATCACCTTTTGGTCTGGAGGGAAGCCTTGGGGCTGATGCAGTTGTTGCCCACAGCTGTATGATTCCCA GCCAGCACAGCCTCTTAGATGCAGTTCTGAAGAAGATGGTACCACCAGTCTGACTGTTTCCATCAAGGGTACACTGCCTTCTCAACTCCA >53021_53021_4_MET-CFTR_MET_chr7_116340338_ENST00000397752_CFTR_chr7_117282492_ENST00000454343_length(amino acids)=641AA_BP=0 MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVL EHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSAL GAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLD AQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRS AMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVI PQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPV TYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKPQIAALKE -------------------------------------------------------------- >53021_53021_5_MET-CFTR_MET_chr7_116340338_ENST00000436117_CFTR_chr7_117282492_ENST00000003084_length(transcript)=3479nt_BP=1200nt ATGAAGGCCCCCGCTGTGCTTGCACCTGGCATCCTCGTGCTCCTGTTTACCTTGGTGCAGAGGAGCAATGGGGAGTGTAAAGAGGCACTA GCAAAGTCCGAGATGAATGTGAATATGAAGTATCAGCTTCCCAACTTCACCGCGGAAACACCCATCCAGAATGTCATTCTACATGAGCAT CACATTTTCCTTGGTGCCACTAACTACATTTATGTTTTAAATGAGGAAGACCTTCAGAAGGTTGCTGAGTACAAGACTGGGCCTGTGCTG GAACACCCAGATTGTTTCCCATGTCAGGACTGCAGCAGCAAAGCCAATTTATCAGGAGGTGTTTGGAAAGATAACATCAACATGGCTCTA GTTGTCGACACCTACTATGATGATCAACTCATTAGCTGTGGCAGCGTCAACAGAGGGACCTGCCAGCGACATGTCTTTCCCCACAATCAT ACTGCTGACATACAGTCGGAGGTTCACTGCATATTCTCCCCACAGATAGAAGAGCCCAGCCAGTGTCCTGACTGTGTGGTGAGCGCCCTG GGAGCCAAAGTCCTTTCATCTGTAAAGGACCGGTTCATCAACTTCTTTGTAGGCAATACCATAAATTCTTCTTATTTCCCAGATCATCCA TTGCATTCGATATCAGTGAGAAGGCTAAAGGAAACGAAAGATGGTTTTATGTTTTTGACGGACCAGTCCTACATTGATGTTTTACCTGAG TTCAGAGATTCTTACCCCATTAAGTATGTCCATGCCTTTGAAAGCAACAATTTTATTTACTTCTTGACGGTCCAAAGGGAAACTCTAGAT GCTCAGACTTTTCACACAAGAATAATCAGGTTCTGTTCCATAAACTCTGGATTGCATTCCTACATGGAAATGCCTCTGGAGTGTATTCTC ACAGAAAAGAGAAAAAAGAGATCCACAAAGAAGGAAGTGTTTAATATACTTCAGGCTGCGTATGTCAGCAAGCCTGGGGCCCAGCTTGCT AGACAAATAGGAGCCAGCCTGAATGATGACATTCTTTTCGGGGTGTTCGCACAAAGCAAGCCAGATTCTGCCGAACCAATGGATCGATCT GCCATGTGTGCATTCCCTATCAAATATGTCAACGACTTCTTCAACAAGATCGTCAACAAAAACAATGTGAGATGTCTCCAGCATTTTTAC GGACCCAATCATGAGCACTGCTTTAATAGGGTGGGCCTCTTGGGAAGAACTGGATCAGGGAAGAGTACTTTGTTATCAGCTTTTTTGAGA CTACTGAACACTGAAGGAGAAATCCAGATCGATGGTGTGTCTTGGGATTCAATAACTTTGCAACAGTGGAGGAAAGCCTTTGGAGTGATA CCACAGAAAGTATTTATTTTTTCTGGAACATTTAGAAAAAACTTGGATCCCTATGAACAGTGGAGTGATCAAGAAATATGGAAAGTTGCA GATGAGGTTGGGCTCAGATCTGTGATAGAACAGTTTCCTGGGAAGCTTGACTTTGTCCTTGTGGATGGGGGCTGTGTCCTAAGCCATGGC CACAAGCAGTTGATGTGCTTGGCTAGATCTGTTCTCAGTAAGGCGAAGATCTTGCTGCTTGATGAACCCAGTGCTCATTTGGATCCAGTA ACATACCAAATAATTAGAAGAACTCTAAAACAAGCATTTGCTGATTGCACAGTAATTCTCTGTGAACACAGGATAGAAGCAATGCTGGAA TGCCAACAATTTTTGGTCATAGAAGAGAACAAAGTGCGGCAGTACGATTCCATCCAGAAACTGCTGAACGAGAGGAGCCTCTTCCGGCAA GCCATCAGCCCCTCCGACAGGGTGAAGCTCTTTCCCCACCGGAACTCAAGCAAGTGCAAGTCTAAGCCCCAGATTGCTGCTCTGAAAGAG GAGACAGAAGAAGAGGTGCAAGATACAAGGCTTTAGAGAGCAGCATAAATGTTGACATGGGACATTTGCTCATGGAATTGGAGCTCGTGG GACAGTCACCTCATGGAATTGGAGCTCGTGGAACAGTTACCTCTGCCTCAGAAAACAAGGATGAATTAAGTTTTTTTTTAAAAAAGAAAC ATTTGGTAAGGGGAATTGAGGACACTGATATGGGTCTTGATAAATGGCTTCCTGGCAATAGTCAAATTGTGTGAAAGGTACTTCAAATCC TTGAAGATTTACCACTTGTGTTTTGCAAGCCAGATTTTCCTGAAAACCCTTGCCATGTGCTAGTAATTGGAAAGGCAGCTCTAAATGTCA ATCAGCCTAGTTGATCAGCTTATTGTCTAGTGAAACTCGTTAATTTGTAGTGTTGGAGAAGAACTGAAATCATACTTCTTAGGGTTATGA TTAAGTAATGATAACTGGAAACTTCAGCGGTTTATATAAGCTTGTATTCCTTTTTCTCTCCTCTCCCCATGATGTTTAGAAACACAACTA TATTGTTTGCTAAGCATTCCAACTATCTCATTTCCAAGCAAGTATTAGAATACCACAGGAACCACAAGACTGCACATCAAAATATGCCCC ATTCAACATCTAGTGAGCAGTCAGGAAAGAGAACTTCCAGATCCTGGAAATCAGGGTTAGTATTGTCCAGGTCTACCAAAAATCTCAATA TTTCAGATAATCACAATACATCCCTTACCTGGGAAAGGGCTGTTATAATCTTTCACAGGGGACAGGATGGTTCCCTTGATGAAGAAGTTG ATATGCCTTTTCCCAACTCCAGAAAGTGACAAGCTCACAGACCTTTGAACTAGAGTTTAGCTGGAAAAGTATGTTAGTGCAAATTGTCAC AGGACAGCCCTTCTTTCCACAGAAGCTCCAGGTAGAGGGTGTGTAAGTAGATAGGCCATGGGCACTGTGGGTAGACACACATGAAGTCCA AGCATTTAGATGTATAGGTTGATGGTGGTATGTTTTCAGGCTAGATGTATGTACTTCATGCTGTCTACACTAAGAGAGAATGAGAGACAC ACTGAAGAAGCACCAATCATGAATTAGTTTTATATGCTTCTGTTTTATAATTTTGTGAAGCAAAATTTTTTCTCTAGGAAATATTTATTT TAATAATGTTTCAAACATATATAACAATGCTGTATTTTAAAAGAATGATTATGAATTACATTTGTATAAAATAATTTTTATATTTGAAAT ATTGACTTTTTATGGCACTAGTATTTCTATGAAATATTATGTTAAAACTGGGACAGGGGAGAACCTAGGGTGATATTAACCAGGGGCCAT GAATCACCTTTTGGTCTGGAGGGAAGCCTTGGGGCTGATGCAGTTGTTGCCCACAGCTGTATGATTCCCAGCCAGCACAGCCTCTTAGAT GCAGTTCTGAAGAAGATGGTACCACCAGTCTGACTGTTTCCATCAAGGGTACACTGCCTTCTCAACTCCAAACTGACTCTTAAGAAGACT >53021_53021_5_MET-CFTR_MET_chr7_116340338_ENST00000436117_CFTR_chr7_117282492_ENST00000003084_length(amino acids)=641AA_BP=0 MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVL EHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSAL GAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLD AQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRS AMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVI PQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPV TYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKPQIAALKE -------------------------------------------------------------- >53021_53021_6_MET-CFTR_MET_chr7_116340338_ENST00000436117_CFTR_chr7_117282492_ENST00000454343_length(transcript)=3483nt_BP=1200nt ATGAAGGCCCCCGCTGTGCTTGCACCTGGCATCCTCGTGCTCCTGTTTACCTTGGTGCAGAGGAGCAATGGGGAGTGTAAAGAGGCACTA GCAAAGTCCGAGATGAATGTGAATATGAAGTATCAGCTTCCCAACTTCACCGCGGAAACACCCATCCAGAATGTCATTCTACATGAGCAT CACATTTTCCTTGGTGCCACTAACTACATTTATGTTTTAAATGAGGAAGACCTTCAGAAGGTTGCTGAGTACAAGACTGGGCCTGTGCTG GAACACCCAGATTGTTTCCCATGTCAGGACTGCAGCAGCAAAGCCAATTTATCAGGAGGTGTTTGGAAAGATAACATCAACATGGCTCTA GTTGTCGACACCTACTATGATGATCAACTCATTAGCTGTGGCAGCGTCAACAGAGGGACCTGCCAGCGACATGTCTTTCCCCACAATCAT ACTGCTGACATACAGTCGGAGGTTCACTGCATATTCTCCCCACAGATAGAAGAGCCCAGCCAGTGTCCTGACTGTGTGGTGAGCGCCCTG GGAGCCAAAGTCCTTTCATCTGTAAAGGACCGGTTCATCAACTTCTTTGTAGGCAATACCATAAATTCTTCTTATTTCCCAGATCATCCA TTGCATTCGATATCAGTGAGAAGGCTAAAGGAAACGAAAGATGGTTTTATGTTTTTGACGGACCAGTCCTACATTGATGTTTTACCTGAG TTCAGAGATTCTTACCCCATTAAGTATGTCCATGCCTTTGAAAGCAACAATTTTATTTACTTCTTGACGGTCCAAAGGGAAACTCTAGAT GCTCAGACTTTTCACACAAGAATAATCAGGTTCTGTTCCATAAACTCTGGATTGCATTCCTACATGGAAATGCCTCTGGAGTGTATTCTC ACAGAAAAGAGAAAAAAGAGATCCACAAAGAAGGAAGTGTTTAATATACTTCAGGCTGCGTATGTCAGCAAGCCTGGGGCCCAGCTTGCT AGACAAATAGGAGCCAGCCTGAATGATGACATTCTTTTCGGGGTGTTCGCACAAAGCAAGCCAGATTCTGCCGAACCAATGGATCGATCT GCCATGTGTGCATTCCCTATCAAATATGTCAACGACTTCTTCAACAAGATCGTCAACAAAAACAATGTGAGATGTCTCCAGCATTTTTAC GGACCCAATCATGAGCACTGCTTTAATAGGGTGGGCCTCTTGGGAAGAACTGGATCAGGGAAGAGTACTTTGTTATCAGCTTTTTTGAGA CTACTGAACACTGAAGGAGAAATCCAGATCGATGGTGTGTCTTGGGATTCAATAACTTTGCAACAGTGGAGGAAAGCCTTTGGAGTGATA CCACAGAAAGTATTTATTTTTTCTGGAACATTTAGAAAAAACTTGGATCCCTATGAACAGTGGAGTGATCAAGAAATATGGAAAGTTGCA GATGAGGTTGGGCTCAGATCTGTGATAGAACAGTTTCCTGGGAAGCTTGACTTTGTCCTTGTGGATGGGGGCTGTGTCCTAAGCCATGGC CACAAGCAGTTGATGTGCTTGGCTAGATCTGTTCTCAGTAAGGCGAAGATCTTGCTGCTTGATGAACCCAGTGCTCATTTGGATCCAGTA ACATACCAAATAATTAGAAGAACTCTAAAACAAGCATTTGCTGATTGCACAGTAATTCTCTGTGAACACAGGATAGAAGCAATGCTGGAA TGCCAACAATTTTTGGTCATAGAAGAGAACAAAGTGCGGCAGTACGATTCCATCCAGAAACTGCTGAACGAGAGGAGCCTCTTCCGGCAA GCCATCAGCCCCTCCGACAGGGTGAAGCTCTTTCCCCACCGGAACTCAAGCAAGTGCAAGTCTAAGCCCCAGATTGCTGCTCTGAAAGAG GAGACAGAAGAAGAGGTGCAAGATACAAGGCTTTAGAGAGCAGCATAAATGTTGACATGGGACATTTGCTCATGGAATTGGAGCTCGTGG GACAGTCACCTCATGGAATTGGAGCTCGTGGAACAGTTACCTCTGCCTCAGAAAACAAGGATGAATTAAGTTTTTTTTTAAAAAAGAAAC ATTTGGTAAGGGGAATTGAGGACACTGATATGGGTCTTGATAAATGGCTTCCTGGCAATAGTCAAATTGTGTGAAAGGTACTTCAAATCC TTGAAGATTTACCACTTGTGTTTTGCAAGCCAGATTTTCCTGAAAACCCTTGCCATGTGCTAGTAATTGGAAAGGCAGCTCTAAATGTCA ATCAGCCTAGTTGATCAGCTTATTGTCTAGTGAAACTCGTTAATTTGTAGTGTTGGAGAAGAACTGAAATCATACTTCTTAGGGTTATGA TTAAGTAATGATAACTGGAAACTTCAGCGGTTTATATAAGCTTGTATTCCTTTTTCTCTCCTCTCCCCATGATGTTTAGAAACACAACTA TATTGTTTGCTAAGCATTCCAACTATCTCATTTCCAAGCAAGTATTAGAATACCACAGGAACCACAAGACTGCACATCAAAATATGCCCC ATTCAACATCTAGTGAGCAGTCAGGAAAGAGAACTTCCAGATCCTGGAAATCAGGGTTAGTATTGTCCAGGTCTACCAAAAATCTCAATA TTTCAGATAATCACAATACATCCCTTACCTGGGAAAGGGCTGTTATAATCTTTCACAGGGGACAGGATGGTTCCCTTGATGAAGAAGTTG ATATGCCTTTTCCCAACTCCAGAAAGTGACAAGCTCACAGACCTTTGAACTAGAGTTTAGCTGGAAAAGTATGTTAGTGCAAATTGTCAC AGGACAGCCCTTCTTTCCACAGAAGCTCCAGGTAGAGGGTGTGTAAGTAGATAGGCCATGGGCACTGTGGGTAGACACACATGAAGTCCA AGCATTTAGATGTATAGGTTGATGGTGGTATGTTTTCAGGCTAGATGTATGTACTTCATGCTGTCTACACTAAGAGAGAATGAGAGACAC ACTGAAGAAGCACCAATCATGAATTAGTTTTATATGCTTCTGTTTTATAATTTTGTGAAGCAAAATTTTTTCTCTAGGAAATATTTATTT TAATAATGTTTCAAACATATATAACAATGCTGTATTTTAAAAGAATGATTATGAATTACATTTGTATAAAATAATTTTTATATTTGAAAT ATTGACTTTTTATGGCACTAGTATTTCTATGAAATATTATGTTAAAACTGGGACAGGGGAGAACCTAGGGTGATATTAACCAGGGGCCAT GAATCACCTTTTGGTCTGGAGGGAAGCCTTGGGGCTGATGCAGTTGTTGCCCACAGCTGTATGATTCCCAGCCAGCACAGCCTCTTAGAT GCAGTTCTGAAGAAGATGGTACCACCAGTCTGACTGTTTCCATCAAGGGTACACTGCCTTCTCAACTCCAAACTGACTCTTAAGAAGACT >53021_53021_6_MET-CFTR_MET_chr7_116340338_ENST00000436117_CFTR_chr7_117282492_ENST00000454343_length(amino acids)=641AA_BP=0 MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVL EHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSAL GAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLD AQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRS AMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVI PQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPV TYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKPQIAALKE -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for MET-CFTR |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000003084 | 21 | 27 | 1386_1480 | 1239.0 | 1481.0 | GORASP2 | |
| Tgene | CFTR | chr7:116340338 | chr7:117282492 | ENST00000454343 | 20 | 26 | 1386_1480 | 1178.0 | 1420.0 | GORASP2 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | MET | chr7:116340338 | chr7:117282492 | ENST00000318493 | + | 2 | 21 | 1320_1359 | 400.0 | 1409.0 | MUC20 |
| Hgene | MET | chr7:116340338 | chr7:117282492 | ENST00000397752 | + | 2 | 21 | 1320_1359 | 400.0 | 1391.0 | MUC20 |
| Hgene | MET | chr7:116340338 | chr7:117282492 | ENST00000436117 | + | 1 | 9 | 1320_1359 | 400.0 | 765.0 | MUC20 |
| Hgene | MET | chr7:116340338 | chr7:117282492 | ENST00000318493 | + | 2 | 21 | 1212_1390 | 400.0 | 1409.0 | RANBP9 |
| Hgene | MET | chr7:116340338 | chr7:117282492 | ENST00000397752 | + | 2 | 21 | 1212_1390 | 400.0 | 1391.0 | RANBP9 |
| Hgene | MET | chr7:116340338 | chr7:117282492 | ENST00000436117 | + | 1 | 9 | 1212_1390 | 400.0 | 765.0 | RANBP9 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for MET-CFTR |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for MET-CFTR |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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