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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MET-TES (FusionGDB2 ID:53037)

Fusion Gene Summary for MET-TES

check button Fusion gene summary
Fusion gene informationFusion gene name: MET-TES
Fusion gene ID: 53037
HgeneTgene
Gene symbol

MET

TES

Gene ID

8731

26136

Gene nameRNA guanine-7 methyltransferasetestin LIM domain protein
SynonymsCMT1|CMT1c|MET|Met|RG7MT1|cm1p|hCMT1|hMetTESS|TESS-2
Cytomap

18p11.21

7q31.2

Type of geneprotein-codingprotein-coding
DescriptionmRNA cap guanine-N7 methyltransferaseRNA (guanine-7-) methyltransferasehcm1pmRNA (guanine-7-)methyltransferasemRNA (guanine-N(7)-)-methyltransferasemRNA cap methyltransferasetestintestis derived transcript (3 LIM domains)
Modification date2020032920200313
UniProtAcc.

PRSS21

Ensembl transtripts involved in fusion geneENST00000318493, ENST00000397752, 
ENST00000436117, ENST00000495962, 
ENST00000539704, 
ENST00000485009, 
ENST00000393481, ENST00000537767, 
ENST00000358204, 
Fusion gene scores* DoF score11 X 10 X 9=9909 X 6 X 7=378
# samples 1610
** MAII scorelog2(16/990*10)=-2.62935662007961
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/378*10)=-1.91838623444635
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MET [Title/Abstract] AND TES [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMET(116340338)-TES(115874588), # samples:1
TES(115850788)-MET(116339125), # samples:1
TES(115850788)-MET(116371722), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMET

GO:0006370

7-methylguanosine mRNA capping

27422871


check buttonFusion gene breakpoints across MET (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TES (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4THCATCGA-ET-A3BU-01AMETchr7

116340338

+TESchr7

115874588

+


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Fusion Gene ORF analysis for MET-TES

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000318493ENST00000485009METchr7

116340338

+TESchr7

115874588

+
5CDS-3UTRENST00000397752ENST00000485009METchr7

116340338

+TESchr7

115874588

+
5CDS-3UTRENST00000436117ENST00000485009METchr7

116340338

+TESchr7

115874588

+
5CDS-5UTRENST00000318493ENST00000393481METchr7

116340338

+TESchr7

115874588

+
5CDS-5UTRENST00000318493ENST00000537767METchr7

116340338

+TESchr7

115874588

+
5CDS-5UTRENST00000397752ENST00000393481METchr7

116340338

+TESchr7

115874588

+
5CDS-5UTRENST00000397752ENST00000537767METchr7

116340338

+TESchr7

115874588

+
5CDS-5UTRENST00000436117ENST00000393481METchr7

116340338

+TESchr7

115874588

+
5CDS-5UTRENST00000436117ENST00000537767METchr7

116340338

+TESchr7

115874588

+
In-frameENST00000318493ENST00000358204METchr7

116340338

+TESchr7

115874588

+
In-frameENST00000397752ENST00000358204METchr7

116340338

+TESchr7

115874588

+
In-frameENST00000436117ENST00000358204METchr7

116340338

+TESchr7

115874588

+
intron-3CDSENST00000495962ENST00000358204METchr7

116340338

+TESchr7

115874588

+
intron-3CDSENST00000539704ENST00000358204METchr7

116340338

+TESchr7

115874588

+
intron-3UTRENST00000495962ENST00000485009METchr7

116340338

+TESchr7

115874588

+
intron-3UTRENST00000539704ENST00000485009METchr7

116340338

+TESchr7

115874588

+
intron-5UTRENST00000495962ENST00000393481METchr7

116340338

+TESchr7

115874588

+
intron-5UTRENST00000495962ENST00000537767METchr7

116340338

+TESchr7

115874588

+
intron-5UTRENST00000539704ENST00000393481METchr7

116340338

+TESchr7

115874588

+
intron-5UTRENST00000539704ENST00000537767METchr7

116340338

+TESchr7

115874588

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000397752METchr7116340338+ENST00000358204TESchr7115874588+394014002002638812
ENST00000318493METchr7116340338+ENST00000358204TESchr7115874588+392713871872625812
ENST00000436117METchr7116340338+ENST00000358204TESchr7115874588+3740120002438812

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000397752ENST00000358204METchr7116340338+TESchr7115874588+0.0003106440.99968934
ENST00000318493ENST00000358204METchr7116340338+TESchr7115874588+0.0003126040.99968743
ENST00000436117ENST00000358204METchr7116340338+TESchr7115874588+0.0003086520.99969137

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Fusion Genomic Features for MET-TES


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MET-TES


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:116340338/chr7:115874588)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.TES

PRSS21

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.314

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTESchr7:116340338chr7:115874588ENST000003582040722_469422.0Compositional biasNote=Cys-rich
TgeneTESchr7:116340338chr7:115874588ENST000003934810722_460413.0Compositional biasNote=Cys-rich
TgeneTESchr7:116340338chr7:115874588ENST0000035820407234_2979422.0DomainLIM zinc-binding 1
TgeneTESchr7:116340338chr7:115874588ENST0000035820407299_3599422.0DomainLIM zinc-binding 2
TgeneTESchr7:116340338chr7:115874588ENST0000035820407362_4219422.0DomainLIM zinc-binding 3
TgeneTESchr7:116340338chr7:115874588ENST000003582040792_1999422.0DomainPET
TgeneTESchr7:116340338chr7:115874588ENST0000039348107234_2970413.0DomainLIM zinc-binding 1
TgeneTESchr7:116340338chr7:115874588ENST0000039348107299_3590413.0DomainLIM zinc-binding 2
TgeneTESchr7:116340338chr7:115874588ENST0000039348107362_4210413.0DomainLIM zinc-binding 3
TgeneTESchr7:116340338chr7:115874588ENST000003934810792_1990413.0DomainPET

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMETchr7:116340338chr7:115874588ENST00000318493+2211078_13454001409.0DomainProtein kinase
HgeneMETchr7:116340338chr7:115874588ENST00000318493+22127_5154001409.0DomainSema
HgeneMETchr7:116340338chr7:115874588ENST00000318493+221563_6554001409.0DomainNote=IPT/TIG 1
HgeneMETchr7:116340338chr7:115874588ENST00000318493+221657_7394001409.0DomainNote=IPT/TIG 2
HgeneMETchr7:116340338chr7:115874588ENST00000318493+221742_8364001409.0DomainNote=IPT/TIG 3
HgeneMETchr7:116340338chr7:115874588ENST00000397752+2211078_13454001391.0DomainProtein kinase
HgeneMETchr7:116340338chr7:115874588ENST00000397752+22127_5154001391.0DomainSema
HgeneMETchr7:116340338chr7:115874588ENST00000397752+221563_6554001391.0DomainNote=IPT/TIG 1
HgeneMETchr7:116340338chr7:115874588ENST00000397752+221657_7394001391.0DomainNote=IPT/TIG 2
HgeneMETchr7:116340338chr7:115874588ENST00000397752+221742_8364001391.0DomainNote=IPT/TIG 3
HgeneMETchr7:116340338chr7:115874588ENST00000436117+191078_1345400765.0DomainProtein kinase
HgeneMETchr7:116340338chr7:115874588ENST00000436117+1927_515400765.0DomainSema
HgeneMETchr7:116340338chr7:115874588ENST00000436117+19563_655400765.0DomainNote=IPT/TIG 1
HgeneMETchr7:116340338chr7:115874588ENST00000436117+19657_739400765.0DomainNote=IPT/TIG 2
HgeneMETchr7:116340338chr7:115874588ENST00000436117+19742_836400765.0DomainNote=IPT/TIG 3
HgeneMETchr7:116340338chr7:115874588ENST00000318493+2211084_10924001409.0Nucleotide bindingATP
HgeneMETchr7:116340338chr7:115874588ENST00000397752+2211084_10924001391.0Nucleotide bindingATP
HgeneMETchr7:116340338chr7:115874588ENST00000436117+191084_1092400765.0Nucleotide bindingATP
HgeneMETchr7:116340338chr7:115874588ENST00000318493+22125_9324001409.0Topological domainExtracellular
HgeneMETchr7:116340338chr7:115874588ENST00000318493+221956_13904001409.0Topological domainCytoplasmic
HgeneMETchr7:116340338chr7:115874588ENST00000397752+22125_9324001391.0Topological domainExtracellular
HgeneMETchr7:116340338chr7:115874588ENST00000397752+221956_13904001391.0Topological domainCytoplasmic
HgeneMETchr7:116340338chr7:115874588ENST00000436117+1925_932400765.0Topological domainExtracellular
HgeneMETchr7:116340338chr7:115874588ENST00000436117+19956_1390400765.0Topological domainCytoplasmic
HgeneMETchr7:116340338chr7:115874588ENST00000318493+221933_9554001409.0TransmembraneHelical
HgeneMETchr7:116340338chr7:115874588ENST00000397752+221933_9554001391.0TransmembraneHelical
HgeneMETchr7:116340338chr7:115874588ENST00000436117+19933_955400765.0TransmembraneHelical


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Fusion Gene Sequence for MET-TES


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>53037_53037_1_MET-TES_MET_chr7_116340338_ENST00000318493_TES_chr7_115874588_ENST00000358204_length(transcript)=3927nt_BP=1387nt
GCCCTCGCCGCCCGCGGCGCCCCGAGCGCTTTGTGAGCAGATGCGGAGCCGAGTGGAGGGCGCGAGCCAGATGCGGGGCGACAGCTGACT
TGCTGAGAGGAGGCGGGGAGGCGCGGAGCGCGCGTGTGGTCCTTGCGCCGCTGACTTCTCCACTGGTTCCTGGGCACCGAAAGATAAACC
TCTCATAATGAAGGCCCCCGCTGTGCTTGCACCTGGCATCCTCGTGCTCCTGTTTACCTTGGTGCAGAGGAGCAATGGGGAGTGTAAAGA
GGCACTAGCAAAGTCCGAGATGAATGTGAATATGAAGTATCAGCTTCCCAACTTCACCGCGGAAACACCCATCCAGAATGTCATTCTACA
TGAGCATCACATTTTCCTTGGTGCCACTAACTACATTTATGTTTTAAATGAGGAAGACCTTCAGAAGGTTGCTGAGTACAAGACTGGGCC
TGTGCTGGAACACCCAGATTGTTTCCCATGTCAGGACTGCAGCAGCAAAGCCAATTTATCAGGAGGTGTTTGGAAAGATAACATCAACAT
GGCTCTAGTTGTCGACACCTACTATGATGATCAACTCATTAGCTGTGGCAGCGTCAACAGAGGGACCTGCCAGCGACATGTCTTTCCCCA
CAATCATACTGCTGACATACAGTCGGAGGTTCACTGCATATTCTCCCCACAGATAGAAGAGCCCAGCCAGTGTCCTGACTGTGTGGTGAG
CGCCCTGGGAGCCAAAGTCCTTTCATCTGTAAAGGACCGGTTCATCAACTTCTTTGTAGGCAATACCATAAATTCTTCTTATTTCCCAGA
TCATCCATTGCATTCGATATCAGTGAGAAGGCTAAAGGAAACGAAAGATGGTTTTATGTTTTTGACGGACCAGTCCTACATTGATGTTTT
ACCTGAGTTCAGAGATTCTTACCCCATTAAGTATGTCCATGCCTTTGAAAGCAACAATTTTATTTACTTCTTGACGGTCCAAAGGGAAAC
TCTAGATGCTCAGACTTTTCACACAAGAATAATCAGGTTCTGTTCCATAAACTCTGGATTGCATTCCTACATGGAAATGCCTCTGGAGTG
TATTCTCACAGAAAAGAGAAAAAAGAGATCCACAAAGAAGGAAGTGTTTAATATACTTCAGGCTGCGTATGTCAGCAAGCCTGGGGCCCA
GCTTGCTAGACAAATAGGAGCCAGCCTGAATGATGACATTCTTTTCGGGGTGTTCGCACAAAGCAAGCCAGATTCTGCCGAACCAATGGA
TCGATCTGCCATGTGTGCATTCCCTATCAAATATGTCAACGACTTCTTCAACAAGATCGTCAACAAAAACAATGTGAGATGTCTCCAGCA
TTTTTACGGACCCAATCATGAGCACTGCTTTAATAGGATGGGCTTAGGTCACGAGCAAGGATTTGGAGCCCCTTGTTTAAAATGCAAAGA
AAAATGTGAAGGATTCGAACTGCACTTCTGGAGAAAAATATGTCGTAACTGCAAGTGTGGCCAAGAAGAGCATGATGTCCTCTTGAGCAA
TGAAGAGGATCGAAAAGTGGGAAAACTTTTTGAAGACACCAAGTATACCACTCTGATTGCAAAACTAAAGTCAGATGGAATTCCCATGTA
TAAACGCAATGTTATGATATTGACGAATCCAGTTGCTGCCAAGAAGAATGTCTCCATCAATACAGTTACCTATGAGTGGGCTCCTCCTGT
CCAGAATCAAGCATTGGCCAGGCAGTACATGCAGATGCTACCCAAGGAAAAGCAGCCAGTAGCAGGCTCAGAGGGGGCACAGTACCGGAA
GAAGCAGCTGGCAAAGCAGCTCCCTGCACATGACCAGGACCCTTCAAAGTGCCATGAGTTGTCTCCCAGAGAGGTGAAGGAGATGGAGCA
GTTTGTGAAGAAATATAAGAGCGAAGCTCTGGGAGTAGGAGATGTCAAACTTCCCTGTGAGATGGATGCCCAAGGCCCCAAACAAATGAA
CATTCCTGGAGGGGATAGAAGCACCCCAGCAGCAGTGGGGGCCATGGAGGACAAATCTGCTGAGCACAAAAGAACTCAATATTCCTGCTA
TTGCTGCAAACTGAGTATGAAAGAAGGTGACCCAGCCATCTATGCCGAAAGGGCTGGCTATGATAAACTGTGGCACCCAGCTTGTTTTGT
CTGCAGCACCTGCCATGAACTCCTGGTTGACATGATTTATTTTTGGAAGAATGAGAAGCTATACTGTGGCAGACATTACTGTGACAGCGA
GAAACCCCGATGTGCTGGCTGTGACGAGCTGATATTCAGCAATGAGTATACCCAGGCAGAAAACCAGAATTGGCACCTGAAACACTTCTG
CTGCTTTGACTGTGATAGCATTCTAGCTGGGGAGATATACGTGATGGTCAATGACAAGCCCGTGTGCAAGCCCTGCTATGTGAAGAATCA
CGCTGTGGTGTGTCAAGGATGCCACAATGCCATCGACCCAGAAGTGCAGCGGGTGACCTATAACAATTTCAGCTGGCATGCATCCACAGA
GTGCTTTCTGTGCTCTTGCTGCAGCAAATGCCTCATTGGGCAGAAGTTCATGCCAGTAGAAGGGATGGTTTTCTGTTCAGTGGAATGTAA
GAAGAGGATGTCTTAGGAGGAGGGCACCCAGAAGTATCGAGCCATAGCTATCCAAAGTGGTCTGCATTTCTACTGTAAAATGCAATTTGA
AAAAAATAAAACGCAAAAAAAGAAACTGTAAAGGAAACCAAGAGATTTTGTTTAATTTTTTTGGCCATTTTTTCTTCATCAATTTTTTTT
CGGTCTCAACTTTTAAACTTGGTTTAAGCATTTGATTTGTAAAACAGTAAATAATTGTATCTTTCCATAGCTTTTCAAATGTGAAATCAT
TTTTGGAAGCTTGGATCTCATTAAACTTCATGTCTCTATTCCATTTGTGCCACACACTTAAAAGTTAGTGTACTGAATGGAAAGATGAGC
ATTCCTAGTTCTACACTTCTTTTTTCCCCCTCATGTGTAAAATGAAAAGAAAACTAAATTTGCCCTAATACCAAGGCGCTACGTTTATTG
CCTCGTCTTATTCACTGACCTTTGTAATGATACACAGTGAATTCTTTTTGACAAAGAGAAATGCAGTGTAGTATGCAGAGCTGCTGTTTT
AATGCCTATGCATTTACTCTTTCCTGATTTAGGCAGAGGTGGCATTTTCTTTATTGCATTTCTCTATTTTTTTAATGTACCCTACCTTCA
GTATTCTCTTTGTAAGTTGGTGACTTGCATCTGTGGCCTTGAATATTTTATTATCACATGTGGCATAACAGTATCCACACTTTTTAGTTC
TTTATTTTTTTTTTTTTATTTTGAGCAATTCTCCTGCCTCAGCCTCCCAAATAGCTGGGATTACAGGTGCATGCCACCACACCCAGCTAA
TTTTTGTATTTTTAGTAGAGACAGGTTTTCACCATGTTAGCCAGGCTGGTCTCAAACTCCTGACCTCAGATGATCCGCCTGCCTTGGCCT
CCCAAAGTGCTGGGATTACAGGTGTGGGAGCCACCATGCCTGACCCACACACTTTTTACTTGTATAGATGATTTTTGGCTTGGACATAAA
AGCCAAGCCACCCATTTGCTTTTAATCCAAAGAACATGTATAGTTTTTGTACCCAGAGACTATGATTTATATTGATTGCACTTGCCTGCC
ATGATTTAGATAAGATTTTTTTTGCATGGTTTTTATTCTTTCCTAATGGATCCTGTTTTATAATACTTCCAAGCCTGTCCATGGATATAT
CAAATGTCTTCACTTGTATATTTTCATGGCTAGGTATTTCTAATGTTTATTCTTCCCTGTGTACTTCTACACATAGCTATGCACTATGAA

>53037_53037_1_MET-TES_MET_chr7_116340338_ENST00000318493_TES_chr7_115874588_ENST00000358204_length(amino acids)=812AA_BP=400
MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVL
EHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSAL
GAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLD
AQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRS
AMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRMGLGHEQGFGAPCLKCKEKCEGFELHFWRKICRNCKCGQEEHDVLLSNEE
DRKVGKLFEDTKYTTLIAKLKSDGIPMYKRNVMILTNPVAAKKNVSINTVTYEWAPPVQNQALARQYMQMLPKEKQPVAGSEGAQYRKKQ
LAKQLPAHDQDPSKCHELSPREVKEMEQFVKKYKSEALGVGDVKLPCEMDAQGPKQMNIPGGDRSTPAAVGAMEDKSAEHKRTQYSCYCC
KLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCF
DCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSVECKKR

--------------------------------------------------------------
>53037_53037_2_MET-TES_MET_chr7_116340338_ENST00000397752_TES_chr7_115874588_ENST00000358204_length(transcript)=3940nt_BP=1400nt
AGGTGACCCGGAGGCCCTCGCCGCCCGCGGCGCCCCGAGCGCTTTGTGAGCAGATGCGGAGCCGAGTGGAGGGCGCGAGCCAGATGCGGG
GCGACAGCTGACTTGCTGAGAGGAGGCGGGGAGGCGCGGAGCGCGCGTGTGGTCCTTGCGCCGCTGACTTCTCCACTGGTTCCTGGGCAC
CGAAAGATAAACCTCTCATAATGAAGGCCCCCGCTGTGCTTGCACCTGGCATCCTCGTGCTCCTGTTTACCTTGGTGCAGAGGAGCAATG
GGGAGTGTAAAGAGGCACTAGCAAAGTCCGAGATGAATGTGAATATGAAGTATCAGCTTCCCAACTTCACCGCGGAAACACCCATCCAGA
ATGTCATTCTACATGAGCATCACATTTTCCTTGGTGCCACTAACTACATTTATGTTTTAAATGAGGAAGACCTTCAGAAGGTTGCTGAGT
ACAAGACTGGGCCTGTGCTGGAACACCCAGATTGTTTCCCATGTCAGGACTGCAGCAGCAAAGCCAATTTATCAGGAGGTGTTTGGAAAG
ATAACATCAACATGGCTCTAGTTGTCGACACCTACTATGATGATCAACTCATTAGCTGTGGCAGCGTCAACAGAGGGACCTGCCAGCGAC
ATGTCTTTCCCCACAATCATACTGCTGACATACAGTCGGAGGTTCACTGCATATTCTCCCCACAGATAGAAGAGCCCAGCCAGTGTCCTG
ACTGTGTGGTGAGCGCCCTGGGAGCCAAAGTCCTTTCATCTGTAAAGGACCGGTTCATCAACTTCTTTGTAGGCAATACCATAAATTCTT
CTTATTTCCCAGATCATCCATTGCATTCGATATCAGTGAGAAGGCTAAAGGAAACGAAAGATGGTTTTATGTTTTTGACGGACCAGTCCT
ACATTGATGTTTTACCTGAGTTCAGAGATTCTTACCCCATTAAGTATGTCCATGCCTTTGAAAGCAACAATTTTATTTACTTCTTGACGG
TCCAAAGGGAAACTCTAGATGCTCAGACTTTTCACACAAGAATAATCAGGTTCTGTTCCATAAACTCTGGATTGCATTCCTACATGGAAA
TGCCTCTGGAGTGTATTCTCACAGAAAAGAGAAAAAAGAGATCCACAAAGAAGGAAGTGTTTAATATACTTCAGGCTGCGTATGTCAGCA
AGCCTGGGGCCCAGCTTGCTAGACAAATAGGAGCCAGCCTGAATGATGACATTCTTTTCGGGGTGTTCGCACAAAGCAAGCCAGATTCTG
CCGAACCAATGGATCGATCTGCCATGTGTGCATTCCCTATCAAATATGTCAACGACTTCTTCAACAAGATCGTCAACAAAAACAATGTGA
GATGTCTCCAGCATTTTTACGGACCCAATCATGAGCACTGCTTTAATAGGATGGGCTTAGGTCACGAGCAAGGATTTGGAGCCCCTTGTT
TAAAATGCAAAGAAAAATGTGAAGGATTCGAACTGCACTTCTGGAGAAAAATATGTCGTAACTGCAAGTGTGGCCAAGAAGAGCATGATG
TCCTCTTGAGCAATGAAGAGGATCGAAAAGTGGGAAAACTTTTTGAAGACACCAAGTATACCACTCTGATTGCAAAACTAAAGTCAGATG
GAATTCCCATGTATAAACGCAATGTTATGATATTGACGAATCCAGTTGCTGCCAAGAAGAATGTCTCCATCAATACAGTTACCTATGAGT
GGGCTCCTCCTGTCCAGAATCAAGCATTGGCCAGGCAGTACATGCAGATGCTACCCAAGGAAAAGCAGCCAGTAGCAGGCTCAGAGGGGG
CACAGTACCGGAAGAAGCAGCTGGCAAAGCAGCTCCCTGCACATGACCAGGACCCTTCAAAGTGCCATGAGTTGTCTCCCAGAGAGGTGA
AGGAGATGGAGCAGTTTGTGAAGAAATATAAGAGCGAAGCTCTGGGAGTAGGAGATGTCAAACTTCCCTGTGAGATGGATGCCCAAGGCC
CCAAACAAATGAACATTCCTGGAGGGGATAGAAGCACCCCAGCAGCAGTGGGGGCCATGGAGGACAAATCTGCTGAGCACAAAAGAACTC
AATATTCCTGCTATTGCTGCAAACTGAGTATGAAAGAAGGTGACCCAGCCATCTATGCCGAAAGGGCTGGCTATGATAAACTGTGGCACC
CAGCTTGTTTTGTCTGCAGCACCTGCCATGAACTCCTGGTTGACATGATTTATTTTTGGAAGAATGAGAAGCTATACTGTGGCAGACATT
ACTGTGACAGCGAGAAACCCCGATGTGCTGGCTGTGACGAGCTGATATTCAGCAATGAGTATACCCAGGCAGAAAACCAGAATTGGCACC
TGAAACACTTCTGCTGCTTTGACTGTGATAGCATTCTAGCTGGGGAGATATACGTGATGGTCAATGACAAGCCCGTGTGCAAGCCCTGCT
ATGTGAAGAATCACGCTGTGGTGTGTCAAGGATGCCACAATGCCATCGACCCAGAAGTGCAGCGGGTGACCTATAACAATTTCAGCTGGC
ATGCATCCACAGAGTGCTTTCTGTGCTCTTGCTGCAGCAAATGCCTCATTGGGCAGAAGTTCATGCCAGTAGAAGGGATGGTTTTCTGTT
CAGTGGAATGTAAGAAGAGGATGTCTTAGGAGGAGGGCACCCAGAAGTATCGAGCCATAGCTATCCAAAGTGGTCTGCATTTCTACTGTA
AAATGCAATTTGAAAAAAATAAAACGCAAAAAAAGAAACTGTAAAGGAAACCAAGAGATTTTGTTTAATTTTTTTGGCCATTTTTTCTTC
ATCAATTTTTTTTCGGTCTCAACTTTTAAACTTGGTTTAAGCATTTGATTTGTAAAACAGTAAATAATTGTATCTTTCCATAGCTTTTCA
AATGTGAAATCATTTTTGGAAGCTTGGATCTCATTAAACTTCATGTCTCTATTCCATTTGTGCCACACACTTAAAAGTTAGTGTACTGAA
TGGAAAGATGAGCATTCCTAGTTCTACACTTCTTTTTTCCCCCTCATGTGTAAAATGAAAAGAAAACTAAATTTGCCCTAATACCAAGGC
GCTACGTTTATTGCCTCGTCTTATTCACTGACCTTTGTAATGATACACAGTGAATTCTTTTTGACAAAGAGAAATGCAGTGTAGTATGCA
GAGCTGCTGTTTTAATGCCTATGCATTTACTCTTTCCTGATTTAGGCAGAGGTGGCATTTTCTTTATTGCATTTCTCTATTTTTTTAATG
TACCCTACCTTCAGTATTCTCTTTGTAAGTTGGTGACTTGCATCTGTGGCCTTGAATATTTTATTATCACATGTGGCATAACAGTATCCA
CACTTTTTAGTTCTTTATTTTTTTTTTTTTATTTTGAGCAATTCTCCTGCCTCAGCCTCCCAAATAGCTGGGATTACAGGTGCATGCCAC
CACACCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGTTTTCACCATGTTAGCCAGGCTGGTCTCAAACTCCTGACCTCAGATGATCCG
CCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGGGAGCCACCATGCCTGACCCACACACTTTTTACTTGTATAGATGATTTTTG
GCTTGGACATAAAAGCCAAGCCACCCATTTGCTTTTAATCCAAAGAACATGTATAGTTTTTGTACCCAGAGACTATGATTTATATTGATT
GCACTTGCCTGCCATGATTTAGATAAGATTTTTTTTGCATGGTTTTTATTCTTTCCTAATGGATCCTGTTTTATAATACTTCCAAGCCTG
TCCATGGATATATCAAATGTCTTCACTTGTATATTTTCATGGCTAGGTATTTCTAATGTTTATTCTTCCCTGTGTACTTCTACACATAGC

>53037_53037_2_MET-TES_MET_chr7_116340338_ENST00000397752_TES_chr7_115874588_ENST00000358204_length(amino acids)=812AA_BP=400
MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVL
EHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSAL
GAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLD
AQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRS
AMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRMGLGHEQGFGAPCLKCKEKCEGFELHFWRKICRNCKCGQEEHDVLLSNEE
DRKVGKLFEDTKYTTLIAKLKSDGIPMYKRNVMILTNPVAAKKNVSINTVTYEWAPPVQNQALARQYMQMLPKEKQPVAGSEGAQYRKKQ
LAKQLPAHDQDPSKCHELSPREVKEMEQFVKKYKSEALGVGDVKLPCEMDAQGPKQMNIPGGDRSTPAAVGAMEDKSAEHKRTQYSCYCC
KLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCF
DCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSVECKKR

--------------------------------------------------------------
>53037_53037_3_MET-TES_MET_chr7_116340338_ENST00000436117_TES_chr7_115874588_ENST00000358204_length(transcript)=3740nt_BP=1200nt
ATGAAGGCCCCCGCTGTGCTTGCACCTGGCATCCTCGTGCTCCTGTTTACCTTGGTGCAGAGGAGCAATGGGGAGTGTAAAGAGGCACTA
GCAAAGTCCGAGATGAATGTGAATATGAAGTATCAGCTTCCCAACTTCACCGCGGAAACACCCATCCAGAATGTCATTCTACATGAGCAT
CACATTTTCCTTGGTGCCACTAACTACATTTATGTTTTAAATGAGGAAGACCTTCAGAAGGTTGCTGAGTACAAGACTGGGCCTGTGCTG
GAACACCCAGATTGTTTCCCATGTCAGGACTGCAGCAGCAAAGCCAATTTATCAGGAGGTGTTTGGAAAGATAACATCAACATGGCTCTA
GTTGTCGACACCTACTATGATGATCAACTCATTAGCTGTGGCAGCGTCAACAGAGGGACCTGCCAGCGACATGTCTTTCCCCACAATCAT
ACTGCTGACATACAGTCGGAGGTTCACTGCATATTCTCCCCACAGATAGAAGAGCCCAGCCAGTGTCCTGACTGTGTGGTGAGCGCCCTG
GGAGCCAAAGTCCTTTCATCTGTAAAGGACCGGTTCATCAACTTCTTTGTAGGCAATACCATAAATTCTTCTTATTTCCCAGATCATCCA
TTGCATTCGATATCAGTGAGAAGGCTAAAGGAAACGAAAGATGGTTTTATGTTTTTGACGGACCAGTCCTACATTGATGTTTTACCTGAG
TTCAGAGATTCTTACCCCATTAAGTATGTCCATGCCTTTGAAAGCAACAATTTTATTTACTTCTTGACGGTCCAAAGGGAAACTCTAGAT
GCTCAGACTTTTCACACAAGAATAATCAGGTTCTGTTCCATAAACTCTGGATTGCATTCCTACATGGAAATGCCTCTGGAGTGTATTCTC
ACAGAAAAGAGAAAAAAGAGATCCACAAAGAAGGAAGTGTTTAATATACTTCAGGCTGCGTATGTCAGCAAGCCTGGGGCCCAGCTTGCT
AGACAAATAGGAGCCAGCCTGAATGATGACATTCTTTTCGGGGTGTTCGCACAAAGCAAGCCAGATTCTGCCGAACCAATGGATCGATCT
GCCATGTGTGCATTCCCTATCAAATATGTCAACGACTTCTTCAACAAGATCGTCAACAAAAACAATGTGAGATGTCTCCAGCATTTTTAC
GGACCCAATCATGAGCACTGCTTTAATAGGATGGGCTTAGGTCACGAGCAAGGATTTGGAGCCCCTTGTTTAAAATGCAAAGAAAAATGT
GAAGGATTCGAACTGCACTTCTGGAGAAAAATATGTCGTAACTGCAAGTGTGGCCAAGAAGAGCATGATGTCCTCTTGAGCAATGAAGAG
GATCGAAAAGTGGGAAAACTTTTTGAAGACACCAAGTATACCACTCTGATTGCAAAACTAAAGTCAGATGGAATTCCCATGTATAAACGC
AATGTTATGATATTGACGAATCCAGTTGCTGCCAAGAAGAATGTCTCCATCAATACAGTTACCTATGAGTGGGCTCCTCCTGTCCAGAAT
CAAGCATTGGCCAGGCAGTACATGCAGATGCTACCCAAGGAAAAGCAGCCAGTAGCAGGCTCAGAGGGGGCACAGTACCGGAAGAAGCAG
CTGGCAAAGCAGCTCCCTGCACATGACCAGGACCCTTCAAAGTGCCATGAGTTGTCTCCCAGAGAGGTGAAGGAGATGGAGCAGTTTGTG
AAGAAATATAAGAGCGAAGCTCTGGGAGTAGGAGATGTCAAACTTCCCTGTGAGATGGATGCCCAAGGCCCCAAACAAATGAACATTCCT
GGAGGGGATAGAAGCACCCCAGCAGCAGTGGGGGCCATGGAGGACAAATCTGCTGAGCACAAAAGAACTCAATATTCCTGCTATTGCTGC
AAACTGAGTATGAAAGAAGGTGACCCAGCCATCTATGCCGAAAGGGCTGGCTATGATAAACTGTGGCACCCAGCTTGTTTTGTCTGCAGC
ACCTGCCATGAACTCCTGGTTGACATGATTTATTTTTGGAAGAATGAGAAGCTATACTGTGGCAGACATTACTGTGACAGCGAGAAACCC
CGATGTGCTGGCTGTGACGAGCTGATATTCAGCAATGAGTATACCCAGGCAGAAAACCAGAATTGGCACCTGAAACACTTCTGCTGCTTT
GACTGTGATAGCATTCTAGCTGGGGAGATATACGTGATGGTCAATGACAAGCCCGTGTGCAAGCCCTGCTATGTGAAGAATCACGCTGTG
GTGTGTCAAGGATGCCACAATGCCATCGACCCAGAAGTGCAGCGGGTGACCTATAACAATTTCAGCTGGCATGCATCCACAGAGTGCTTT
CTGTGCTCTTGCTGCAGCAAATGCCTCATTGGGCAGAAGTTCATGCCAGTAGAAGGGATGGTTTTCTGTTCAGTGGAATGTAAGAAGAGG
ATGTCTTAGGAGGAGGGCACCCAGAAGTATCGAGCCATAGCTATCCAAAGTGGTCTGCATTTCTACTGTAAAATGCAATTTGAAAAAAAT
AAAACGCAAAAAAAGAAACTGTAAAGGAAACCAAGAGATTTTGTTTAATTTTTTTGGCCATTTTTTCTTCATCAATTTTTTTTCGGTCTC
AACTTTTAAACTTGGTTTAAGCATTTGATTTGTAAAACAGTAAATAATTGTATCTTTCCATAGCTTTTCAAATGTGAAATCATTTTTGGA
AGCTTGGATCTCATTAAACTTCATGTCTCTATTCCATTTGTGCCACACACTTAAAAGTTAGTGTACTGAATGGAAAGATGAGCATTCCTA
GTTCTACACTTCTTTTTTCCCCCTCATGTGTAAAATGAAAAGAAAACTAAATTTGCCCTAATACCAAGGCGCTACGTTTATTGCCTCGTC
TTATTCACTGACCTTTGTAATGATACACAGTGAATTCTTTTTGACAAAGAGAAATGCAGTGTAGTATGCAGAGCTGCTGTTTTAATGCCT
ATGCATTTACTCTTTCCTGATTTAGGCAGAGGTGGCATTTTCTTTATTGCATTTCTCTATTTTTTTAATGTACCCTACCTTCAGTATTCT
CTTTGTAAGTTGGTGACTTGCATCTGTGGCCTTGAATATTTTATTATCACATGTGGCATAACAGTATCCACACTTTTTAGTTCTTTATTT
TTTTTTTTTTATTTTGAGCAATTCTCCTGCCTCAGCCTCCCAAATAGCTGGGATTACAGGTGCATGCCACCACACCCAGCTAATTTTTGT
ATTTTTAGTAGAGACAGGTTTTCACCATGTTAGCCAGGCTGGTCTCAAACTCCTGACCTCAGATGATCCGCCTGCCTTGGCCTCCCAAAG
TGCTGGGATTACAGGTGTGGGAGCCACCATGCCTGACCCACACACTTTTTACTTGTATAGATGATTTTTGGCTTGGACATAAAAGCCAAG
CCACCCATTTGCTTTTAATCCAAAGAACATGTATAGTTTTTGTACCCAGAGACTATGATTTATATTGATTGCACTTGCCTGCCATGATTT
AGATAAGATTTTTTTTGCATGGTTTTTATTCTTTCCTAATGGATCCTGTTTTATAATACTTCCAAGCCTGTCCATGGATATATCAAATGT
CTTCACTTGTATATTTTCATGGCTAGGTATTTCTAATGTTTATTCTTCCCTGTGTACTTCTACACATAGCTATGCACTATGAAAATTAAA

>53037_53037_3_MET-TES_MET_chr7_116340338_ENST00000436117_TES_chr7_115874588_ENST00000358204_length(amino acids)=812AA_BP=400
MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVL
EHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSAL
GAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLD
AQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRS
AMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRMGLGHEQGFGAPCLKCKEKCEGFELHFWRKICRNCKCGQEEHDVLLSNEE
DRKVGKLFEDTKYTTLIAKLKSDGIPMYKRNVMILTNPVAAKKNVSINTVTYEWAPPVQNQALARQYMQMLPKEKQPVAGSEGAQYRKKQ
LAKQLPAHDQDPSKCHELSPREVKEMEQFVKKYKSEALGVGDVKLPCEMDAQGPKQMNIPGGDRSTPAAVGAMEDKSAEHKRTQYSCYCC
KLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCF
DCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSVECKKR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MET-TES


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMETchr7:116340338chr7:115874588ENST00000318493+2211320_1359400.01409.0MUC20
HgeneMETchr7:116340338chr7:115874588ENST00000397752+2211320_1359400.01391.0MUC20
HgeneMETchr7:116340338chr7:115874588ENST00000436117+191320_1359400.0765.0MUC20
HgeneMETchr7:116340338chr7:115874588ENST00000318493+2211212_1390400.01409.0RANBP9
HgeneMETchr7:116340338chr7:115874588ENST00000397752+2211212_1390400.01391.0RANBP9
HgeneMETchr7:116340338chr7:115874588ENST00000436117+191212_1390400.0765.0RANBP9


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MET-TES


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MET-TES


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource