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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:METTL14-PRMT1 (FusionGDB2 ID:53055) |
Fusion Gene Summary for METTL14-PRMT1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: METTL14-PRMT1 | Fusion gene ID: 53055 | Hgene | Tgene | Gene symbol | METTL14 | PRMT1 | Gene ID | 57721 | 3276 |
| Gene name | methyltransferase like 14 | protein arginine methyltransferase 1 | |
| Synonyms | hMETTL14 | ANM1|HCP1|HRMT1L2|IR1B4 | |
| Cytomap | 4q26 | 19q13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | N6-adenosine-methyltransferase non-catalytic subunitN6-adenosine-methyltransferase subunit METTL14methyltransferase-like protein 14 | protein arginine N-methyltransferase 1HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2heterogeneous nuclear ribonucleoprotein methyltransferase 1-like 2histone-arginine N-methyltransferase PRMT1interferon receptor 1-bound protein 4 | |
| Modification date | 20200313 | 20200329 | |
| UniProtAcc | Q9HCE5 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000388822, ENST00000506780, | ENST00000527866, ENST00000391851, ENST00000454376, ENST00000532489, | |
| Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 4 X 5 X 4=80 |
| # samples | 4 | 5 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: METTL14 [Title/Abstract] AND PRMT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | METTL14(119631336)-PRMT1(50187187), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | METTL14 | GO:0080009 | mRNA methylation | 27281194|27373337|27627798 |
| Tgene | PRMT1 | GO:0016571 | histone methylation | 19405910 |
| Tgene | PRMT1 | GO:0018216 | peptidyl-arginine methylation | 18657504|19460357|26575292 |
| Tgene | PRMT1 | GO:0043985 | histone H4-R3 methylation | 11448779 |
| Tgene | PRMT1 | GO:0045652 | regulation of megakaryocyte differentiation | 26575292 |
| Tgene | PRMT1 | GO:0045653 | negative regulation of megakaryocyte differentiation | 20442406 |
| Tgene | PRMT1 | GO:0051260 | protein homooligomerization | 26876602 |
| Fusion gene breakpoints across METTL14 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across PRMT1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | GBM | TCGA-06-0157-01A | METTL14 | chr4 | 119631336 | + | PRMT1 | chr19 | 50187187 | + |
| ChimerDB4 | GBM | TCGA-06-0644-01A | METTL14 | chr4 | 119631336 | + | PRMT1 | chr19 | 50187187 | + |
| ChimerDB4 | GBM | TCGA-12-3652-01A | METTL14 | chr4 | 119631336 | + | PRMT1 | chr19 | 50187187 | + |
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Fusion Gene ORF analysis for METTL14-PRMT1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000388822 | ENST00000527866 | METTL14 | chr4 | 119631336 | + | PRMT1 | chr19 | 50187187 | + |
| 5CDS-intron | ENST00000506780 | ENST00000527866 | METTL14 | chr4 | 119631336 | + | PRMT1 | chr19 | 50187187 | + |
| In-frame | ENST00000388822 | ENST00000391851 | METTL14 | chr4 | 119631336 | + | PRMT1 | chr19 | 50187187 | + |
| In-frame | ENST00000388822 | ENST00000454376 | METTL14 | chr4 | 119631336 | + | PRMT1 | chr19 | 50187187 | + |
| In-frame | ENST00000388822 | ENST00000532489 | METTL14 | chr4 | 119631336 | + | PRMT1 | chr19 | 50187187 | + |
| In-frame | ENST00000506780 | ENST00000391851 | METTL14 | chr4 | 119631336 | + | PRMT1 | chr19 | 50187187 | + |
| In-frame | ENST00000506780 | ENST00000454376 | METTL14 | chr4 | 119631336 | + | PRMT1 | chr19 | 50187187 | + |
| In-frame | ENST00000506780 | ENST00000532489 | METTL14 | chr4 | 119631336 | + | PRMT1 | chr19 | 50187187 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000388822 | METTL14 | chr4 | 119631336 | + | ENST00000532489 | PRMT1 | chr19 | 50187187 | + | 7391 | 6485 | 167 | 1360 | 397 |
| ENST00000388822 | METTL14 | chr4 | 119631336 | + | ENST00000391851 | PRMT1 | chr19 | 50187187 | + | 7391 | 6485 | 167 | 1360 | 397 |
| ENST00000388822 | METTL14 | chr4 | 119631336 | + | ENST00000454376 | PRMT1 | chr19 | 50187187 | + | 7391 | 6485 | 167 | 1360 | 397 |
| ENST00000506780 | METTL14 | chr4 | 119631336 | + | ENST00000532489 | PRMT1 | chr19 | 50187187 | + | 2517 | 1611 | 237 | 1316 | 359 |
| ENST00000506780 | METTL14 | chr4 | 119631336 | + | ENST00000391851 | PRMT1 | chr19 | 50187187 | + | 2517 | 1611 | 237 | 1316 | 359 |
| ENST00000506780 | METTL14 | chr4 | 119631336 | + | ENST00000454376 | PRMT1 | chr19 | 50187187 | + | 2517 | 1611 | 237 | 1316 | 359 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000388822 | ENST00000532489 | METTL14 | chr4 | 119631336 | + | PRMT1 | chr19 | 50187187 | + | 0.000123254 | 0.99987674 |
| ENST00000388822 | ENST00000391851 | METTL14 | chr4 | 119631336 | + | PRMT1 | chr19 | 50187187 | + | 0.000123254 | 0.99987674 |
| ENST00000388822 | ENST00000454376 | METTL14 | chr4 | 119631336 | + | PRMT1 | chr19 | 50187187 | + | 0.000123254 | 0.99987674 |
| ENST00000506780 | ENST00000532489 | METTL14 | chr4 | 119631336 | + | PRMT1 | chr19 | 50187187 | + | 0.001664709 | 0.9983353 |
| ENST00000506780 | ENST00000391851 | METTL14 | chr4 | 119631336 | + | PRMT1 | chr19 | 50187187 | + | 0.001664709 | 0.9983353 |
| ENST00000506780 | ENST00000454376 | METTL14 | chr4 | 119631336 | + | PRMT1 | chr19 | 50187187 | + | 0.001664709 | 0.9983353 |
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Fusion Genomic Features for METTL14-PRMT1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for METTL14-PRMT1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:119631336/chr19:50187187) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| METTL14 | . |
| FUNCTION: The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis (PubMed:24316715, PubMed:24407421, PubMed:25719671, PubMed:29348140, PubMed:27373337, PubMed:27281194). In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core (PubMed:27627798, PubMed:27373337, PubMed:27281194, PubMed:29348140). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing (PubMed:24316715, PubMed:24407421, PubMed:25719671). M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation (By similarity). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization (By similarity). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). {ECO:0000250|UniProtKB:Q3UIK4, ECO:0000269|PubMed:24316715, ECO:0000269|PubMed:24407421, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:27281194, ECO:0000269|PubMed:27373337, ECO:0000269|PubMed:27627798, ECO:0000269|PubMed:29348140}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | METTL14 | chr4:119631336 | chr19:50187187 | ENST00000388822 | + | 1 | 11 | 409_452 | 0 | 457.0 | Compositional bias | Note=Gly-rich |
| Hgene | METTL14 | chr4:119631336 | chr19:50187187 | ENST00000388822 | + | 1 | 11 | 245_254 | 0 | 457.0 | Region | Positively charged region required for RNA-binding |
| Tgene | PRMT1 | chr4:119631336 | chr19:50187187 | ENST00000391851 | 3 | 10 | 50_361 | 119 | 354.0 | Domain | SAM-dependent MTase PRMT-type |
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Fusion Gene Sequence for METTL14-PRMT1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >53055_53055_1_METTL14-PRMT1_METTL14_chr4_119631336_ENST00000388822_PRMT1_chr19_50187187_ENST00000391851_length(transcript)=7391nt_BP=6485nt GCGAGCCAATTCCGGCCGCGCCGGAAGTCTCTACTGAGGAAAGCTATGAGGATACTCTGTTCGTAAGCTCCCGGTGAATTTTGTTCCACA GACTCGGAAGAAAGGTTGGATAAGAGTTCACTGGAGATTGACAAGTACTCGGGATAGTGAAAAGCCGGAGTTGGAACATGGATAGCCGCT TGCAGGAGATCCGGGAGCGGCAGAAGTTACGGCGACAGCTCCTCGCGCAGCAGTTGGGAGCTGAAAGTGCCGACAGCATTGGTGCCGTGT TAAATAGCAAAGATGAGCAGAGAGAAATTGCTGAAACAAGAGAAACTTGCAGGGCTTCCTATGATACCTCTGCTCCAAATGCAAAACGTA AGTATCTGGATGAAGGAGAGACAGATGAAGACAAAATGGAAGAATATAAGGATGAACTAGAAATGCAACAGGATGAAGAAAATTTGCCAT ATGAAGAAGAGATTTACAAAGATTCTAGTACTTTTCTTAAGGGAACACAGAGCTTAAATCCCCATAATGATTACTGCCAACATTTTGTAG ACACTGGACATAGACCTCAGAATTTCATCAGGGATGTAGGTTTAGCTGACAGATTTGAAGAATATCCTAAACTGAGGGAGCTCATCAGGC TAAAGGATGAGTTAATAGCTAAATCTAACACTCCTCCCATGTACTTACAAGCCGATATAGAAGCCTTTGACATCAGAGAACTAACACCCA AATTTGATGTGATTCTTCTGGAACCCCCTTTAGAAGAATATTACAGAGAAACTGGCATCACTGCTAATGAAAAATGCTGGACTTGGGATG ATATTATGAAGTTAGAAATTGATGAGATTGCAGCACCTCGATCATTTATTTTTCTCTGGTGTGGTTCTGGGGAGGGGTTGGACCTTGGAA GAGTGTGTTTACGAAAATGGGGTTACAGAAGATGTGAAGATATTTGTTGGATTAAAACCAATAAAAACAATCCTGGGAAGACTAAGACTT TAGATCCAAAGGCTGTCTTTCAGAGAACAAAGGAACACTGCCTCATGGGGATCAAAGGAACTGTGAAGCGTAGCACAGACGGGGACTTCA TTCATGCTAATGTTGACATTGACTTAATTATCACAGAAGAACCTGAAATTGGCAATATAGAAAAACCTGTAGAAATTTTTCATATAATTG AGCATTTTTGTCTTGGTAGAAGACGCCTTCATCTATTTGGAAGAGATAGTACAATTCGACCAGAAGAGGTGGAACTTCTGCTGGCCGTGG ACGAGAAAGAAATAGATCTAACTTCCGAGGAGAAAGAGGTGGCTTTAGAGGGGGCCGTGGAGGAGCACACAGAGGTGGCTTTCCACCTCG ATAATTGTTGAAGACATTGAACCTATTCATCCTCCTCTAACCTTCTTTATTGTAATTAAATTTCAAGTGGGAGACTTAACTTTAGAACTC ACTTCCAGCTTGCACTTTGCTTTAATTTCTCTGAGCTGCAAGAATGTCTTAGCGAGCCTTGCTTGCAGTTGTCACACACACTGTCTGGTT TTTTTCAGGATAAATGAATGATTCTGCCTTTTGTTATGTGCGTGAACAGAATGGAACAACTCAAGTAGCTTCATCTTCAGAGACTGAATT TATTCTGATAGACTTCAGCTAATTACAAAGGATTTTGCTAATTTTTGGGAATAAATAATGGAAAAAGATCCAGTCTGTGGTATCATGCTA GTGCTGACAGGGCCTTGATAGAATAGAGTTGGAAAAGATGGTAAGCTTTTGTCAGGGTTTTAACATTTTCTTGATGAAACAATAAAAAGA GGTAAGCTTTTTTCTTCTTTTTTTTTAAGTTTTAAATAAACTCAGATATAATTTGAATACTGAAGAAATTAAGAGACTTTGAACAAAAAC TCTTCCCAAATCTAAATTTGATAGGGGAGGTGGAGATTCCAGGGGTGGGTGAAAGAAGAGATAGAACTTAGCAGGCAGACTTAAAAAAAA AAAAAAAGTTTATCATCATAATCTCAATTTTGTGGCTATGACTCCTAATCACGCTTCCTAAGAAGCAAAGGAGGACAAATATTCATGTGC TAGATAGCACTGTGGTGTGGACTTGAACTTGGATTGACCTTAAATTTTATATTCCTCAAATAAAAGAGAGGCAGCGACAAGATACCTCAT TATCAGATGCTTGGTTTATACATTTTGGGACTAAAATACTTGGTGATGAAATGACATACACCTTTAAACTTGTTATGGAGATAGTTTAAT GTAAAACCAACTACGGAAAACCCTCAACTTAAGGATACAGCTTGGAAATTGGAACTGCAATTGCCTTTTATTAAAACCATATGGTGTGAT GTTTGTTTTTAAAATTATATAAGACTTTATGCTGTCACTTCTCTTGCTGTACTGTAATTCATGTTTTAAATGAATTTGATAATGAAATTA TACTATTATCATTCTTGATGAATACTTTTCTTATTTTTATGATTTTTCTAATGAAACTTTAAACTTTTGAGATTTGAGAGTCTGTTTTCT ATAAGTAGAATTACTGTTGTTACAAAATGAAAAAGGACTGACCTAAAATCAGTCTCTTCTTTTGGTCTGTGATGGATTTTAATGGCCGTT CTGTGCTCATATATACCTAAGATGAGATTATATTACATCCACCAAAGACTCAGTTTGAAGATAAGGAATGAGTGATAGAAGAAATAAGGC TGAGATCCTTAAAAGCCTAATTAATTTAACTCGCTTAACCCATTAGTACTATCTAGTACAAGACCCCTTTTTTTTTGCTGAAATTATGGT ATATTTTCAACTTCACTAATTACAAATTATCTAGATTTAGAACTCTATATGTCAGCATTGACCTGGGAATGAAGTCAGGATAGAGAAATT CCACTTGCCTGTGATGGGTCCTTAGAAGTATCAGCTAAGGAGTGACCCTGTCCTATACACAGGGCTCTCTATTACGTTCCATACCCTGGG CCTACCCAAGGTGACATTCCTGCTGTTTACATGGCATAGGCACCTGTGAGATCAGTGTCACAATTTCATCTTAGAAAGAGGTAGGTATGG CTGCTTTGTCGGTTGAAAGTTAAGGGGAGCCATGATCTACCATATTTAGGAAAAAGTTATTTAAAAAAGAGCAGATGGTGGAAAAAGAAT GTAAGACCCAGAATTTATCCCTTTGACAATGAATCTGGCCTTTTTAATAGCAGGATGGAATTGATTCACTAGTTTTTGCTAACTTTCACT TTCAGTAAAGGTTGAGGTGTTGTTTTTGCAATGACTGTGTATTCATTGAGGAAAGGTTTCCAATGAAATTTCATTACTCTGACCTCTTCT AATTTTTGGTCTTCTTTATATTTACATGTCTTACATTCCACAAAATTATTTAGAAATGCTGGGCATGGTGGCTCATGCCTGTAATCCCAG CACTTTGTGAGGCCGATGTGGGTGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGACCAATATGGAGAAATCCCATCTCTACTAAAA ATACAAAATTAGCTGGGCGTGGTGGCATGTGCACGCCTGTAATCCCCGCTACTCGGGAGGCTGTGGCAGGAGAATTGCCTGAACCCAGGA GGCGGAGGTTGCAGTGAGCCGAGATTGTGCCACTGCACTCCAGCCTGGGCGACAGAGTGAGACTCTGTCTCAAAAAAAAAAAAAAAAATT GTATAGAAATAAATTTTTAGTTGCTTTATGCACTAATTCCTTACTGGGGATAGAAGCTAATTATTGTGAAATAACCTAGTTTAGAAGTTA GAAGATCAGCATGTCTGAGTTTTTACAGAATTATAATTCATGGTATTCCAAACCAACTGTTGTTATTTATTTCCAGTGAGAACCATTTTC CCACTGACCTTCCTCCTTTCAGAGGATGGGGATTAGGAGGCCCAAAGTACTGATTGAGTAGGAATACTTTTTTACTCTTCTTCACTGTGG AGAAAGAAGAGGGCAGGTAGTTGATGATGTCAGGAGAACAGATTTTATGGTGTGGAATACCATACCTAAACACAAATGAATCAGATTAGA CCACAGAATTGTGATGATGGCAGTCAGAATGTAATACGGTCATCATGAAACAGCACAGTGTGAGAGGTCAAGGTGTCAACCTGGGAAGTG AGAATCAAGCAGGAGTGTGGCATGGCAACCAACTCACAGATCCAGAGTTGAGAGGGATCACTACTGCAGCAGTTCTGCTCTGTTACTCTG GTAAGTAGTAGAGCCACTTTATGAGCCCTTATTTCCTATCTCCCTTATTCTGAGGCCAGGTCAGTGATATGCTATAGTTTCATTTAAGTT AATGGAGTATAAAGATGGGATACTTGGGAGCTATATTGTGCATCAGGGTGTCACAGCTGCTACTAGGAGTTACTCCTTTTCATGTCTTTT AAAATACTTTCTACCCATCTTAATTGCTAAATTATCTTTCAGTTAGTTACAGCGCTTAATTTAAAACCTGTACTGTTTTCATCCTGAATT TAGAACATAAGATTTAGCCTTTGAAGTATAGTTTCAGACTTTACTAATTTGTTTAATATAATCCTTATTAACATGACAAAATGAAAGCCC TGTTGGGACTTAGTCTAAACAGTAGTCTTTGATCTGAAAGTGTCTCATATTTTGTGATCTATTAGAAACATAAACCTTTGCTTATGCAGA AGGTCTTTCTTAGAACAATCCTGTAATCTTAGGGTTCATGTGTGACTAGCATTATCCTCTCTTTGATGTTGGGTAATAGAGGCTGAACTT TTCTTGTGTATATATAGTTAGTTTTGAGGCCATAAATCTAGGACTTCTCAAAAGATTAGAACATTTATCCAGTAAACTGACTCCATTGAA GACTTCATTTCTGGAAATACCACATTGCTTCTGCTCTCAATAACTCTATCATTTACTCGTATAAATATTGCTAGCTGTAATGCACAGAGA AAAACTACCTCATTCAATCTAGATAATTGGGACATCCTTTTCCAGTAAACCCTTTTTCCACTACTGGATAAAATATTAAAATGATCAGTT TGAGTGTATGTTAGAGTTCATGTTTCTGTAACTAAAGGTGCTAATAAACTGAAATCAGATAAGGTAGGTTTTTCCAAAAATACTTCTAAA TAATTGACAACCTAGAAGTCAACAATGTAAAATGCATATGGGACTCTATATTAATAGAGAAGCAGGCCAAGAACTTTTTAATGGGATAAT TGTCTTCTTTAGGCACATTGTTTGCATATTAACGACATGGAAATATTTTCACTCATTTACTTTCATCCATCTATCTGTGCTTTTTCTCAC TTTGATGAGTTCTCTCAACTCCTTTCTAAGAAAAGCAGAGCAGAGCAGCATAGAGTGCGTTAGTAAATGGCCACTGACTCTTGGTCTCAG GCCATAGCAACTATAGAGAGAAGAGTGGGGCTGGAGACCTCATACCCTGGGTAAAGTGGACATCACTTGTCAGCTCCAGCTAATTGTCAC CACAGAGAGAAGAGGGTAAGTCTGAGATGTTCATGTGCATTTCCCTACATTTTAGAGGTTGACAAAATAGTTTGTGACTTTTGCTTACAT TTGCATTCATAGAACTAAAAAAAATTTAACTTGGCTAACAAAATACCACATGCATATTTTCTTTTTTATTTTTATTTTTTGAGACAGAGT CTCTGTTACCCAGGCTGGGGGGCAGTGATAAGATCTTGGCTCACTGCAACCTCCGCCTCCAGGGTTGAAGCGATTCTTCTGCCTCAGCCT CCTGAGTAGCTGGAATTACAGGTGCCCACCACCACACCCAGCTAATTTTAGTATTCTTAGTAGAGACAGGATTTCACCATGTTGGCCAGG CTGGTCTCAAACTCCCGACCTCAACTGATCCACCCACCCTGGCCTCCCAAAGTGTCAGGATTACAGGCGTGAGCCTCTGCAACTGGCCAA CATGCATATTTAAATTATGCATGCATTGTAGCTGTATACTGTGTGACCACATTTACTTAAAAAAGAGGAAAAAAGGTTACTTGCTTGAGA CAGGAAACTATCACCTTTGAAAGCATATTAAGTAGTTGGCTTACTTTGGAACACACAGTAGACTGAAAATGTGAACTAATACTTTAAAAT TGCCGTATAATGATGTCATTGCAAGCCATTCATCTATCCAATGGGGGAAAATGTGGAGGTCTAGGCTTGTGTTGTCACAAAATACACCTT TTAGATAATCCTTACCTGTACAGATTTTTATAACTGTTGTTATCATAAGAGAATGGCTACATCATTATCCTGCCTTTTCTGGGTGTTTAT TTTGTTGTTTTTGAAAGTGGACAAAACCTCAAAGCACAATTTTGTTCTGATATATCCAGTTTAGTAGTTTATGCTGGTTAAATGATCAAA GTAATTGCTTAAATGTCTTGTGGAATTAGCTGTCACTTTATAGTTTATGTATTGTGGTGGGTACCTTAATAATAAAAAGATTTTTAATGT AATAATGGTGACCATCATCAAGGGGAAGGTGGAGGAGGTGGAGCTCCCAGTGGAGAAGGTGGACATCATCATCAGCGAGTGGATGGGCTA CTGCCTCTTCTACGAGTCCATGCTCAACACCGTGCTCTATGCCCGGGACAAGTGGCTGGCGCCCGATGGCCTCATCTTCCCAGACCGGGC CACGCTGTATGTGACGGCCATCGAGGACCGGCAGTACAAAGACTACAAGATCCACTGGTGGGAGAACGTGTATGGCTTCGACATGTCTTG CATCAAAGATGTGGCCATTAAGGAGCCCCTAGTGGATGTCGTGGACCCCAAACAGCTGGTCACCAACGCCTGCCTCATAAAGGAGGTGGA CATCTATACCGTCAAGGTGGAAGACCTGACCTTCACCTCCCCGTTCTGCCTGCAAGTGAAGCGGAATGACTACGTGCACGCCCTGGTGGC CTACTTCAACATCGAGTTCACACGCTGCCACAAGAGGACCGGCTTCTCCACCAGCCCCGAGTCCCCGTACACGCACTGGAAGCAGACGGT GTTCTACATGGAGGACTACCTGACCGTGAAGACGGGCGAGGAGATCTTCGGCACCATCGGCATGCGGCCCAACGCCAAGAACAACCGGGA CCTGGACTTCACCATCGACCTGGACTTCAAGGGCCAGCTGTGCGAGCTGTCCTGCTCCACCGACTACCGGATGCGCTGAGGCCCGGCTCT CCCGCCCTGCACGAGCCCAGGGGCTGAGCGTTCCTAGGCGGTTTCGGGGCTCCCCCTTCCTCTCCCTCCCTCCCGCAGAAGGGGGTTTTA GGGGCCTGGGCTGGGGGGATGGGGAGGGCACATCGTGACTGTGTTTTTCATAACTTATGTTTTTATATGGTTGCATTTACGCCAATAAAT >53055_53055_1_METTL14-PRMT1_METTL14_chr4_119631336_ENST00000388822_PRMT1_chr19_50187187_ENST00000391851_length(amino acids)=397AA_BP= MDSRLQEIRERQKLRRQLLAQQLGAESADSIGAVLNSKDEQREIAETRETCRASYDTSAPNAKRKYLDEGETDEDKMEEYKDELEMQQDE ENLPYEEEIYKDSSTFLKGTQSLNPHNDYCQHFVDTGHRPQNFIRDVGLADRFEEYPKLRELIRLKDELIAKSNTPPMYLQADIEAFDIR ELTPKFDVILLEPPLEEYYRETGITANEKCWTWDDIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPG KTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPEEVEL -------------------------------------------------------------- >53055_53055_2_METTL14-PRMT1_METTL14_chr4_119631336_ENST00000388822_PRMT1_chr19_50187187_ENST00000454376_length(transcript)=7391nt_BP=6485nt GCGAGCCAATTCCGGCCGCGCCGGAAGTCTCTACTGAGGAAAGCTATGAGGATACTCTGTTCGTAAGCTCCCGGTGAATTTTGTTCCACA GACTCGGAAGAAAGGTTGGATAAGAGTTCACTGGAGATTGACAAGTACTCGGGATAGTGAAAAGCCGGAGTTGGAACATGGATAGCCGCT TGCAGGAGATCCGGGAGCGGCAGAAGTTACGGCGACAGCTCCTCGCGCAGCAGTTGGGAGCTGAAAGTGCCGACAGCATTGGTGCCGTGT TAAATAGCAAAGATGAGCAGAGAGAAATTGCTGAAACAAGAGAAACTTGCAGGGCTTCCTATGATACCTCTGCTCCAAATGCAAAACGTA AGTATCTGGATGAAGGAGAGACAGATGAAGACAAAATGGAAGAATATAAGGATGAACTAGAAATGCAACAGGATGAAGAAAATTTGCCAT ATGAAGAAGAGATTTACAAAGATTCTAGTACTTTTCTTAAGGGAACACAGAGCTTAAATCCCCATAATGATTACTGCCAACATTTTGTAG ACACTGGACATAGACCTCAGAATTTCATCAGGGATGTAGGTTTAGCTGACAGATTTGAAGAATATCCTAAACTGAGGGAGCTCATCAGGC TAAAGGATGAGTTAATAGCTAAATCTAACACTCCTCCCATGTACTTACAAGCCGATATAGAAGCCTTTGACATCAGAGAACTAACACCCA AATTTGATGTGATTCTTCTGGAACCCCCTTTAGAAGAATATTACAGAGAAACTGGCATCACTGCTAATGAAAAATGCTGGACTTGGGATG ATATTATGAAGTTAGAAATTGATGAGATTGCAGCACCTCGATCATTTATTTTTCTCTGGTGTGGTTCTGGGGAGGGGTTGGACCTTGGAA GAGTGTGTTTACGAAAATGGGGTTACAGAAGATGTGAAGATATTTGTTGGATTAAAACCAATAAAAACAATCCTGGGAAGACTAAGACTT TAGATCCAAAGGCTGTCTTTCAGAGAACAAAGGAACACTGCCTCATGGGGATCAAAGGAACTGTGAAGCGTAGCACAGACGGGGACTTCA TTCATGCTAATGTTGACATTGACTTAATTATCACAGAAGAACCTGAAATTGGCAATATAGAAAAACCTGTAGAAATTTTTCATATAATTG AGCATTTTTGTCTTGGTAGAAGACGCCTTCATCTATTTGGAAGAGATAGTACAATTCGACCAGAAGAGGTGGAACTTCTGCTGGCCGTGG ACGAGAAAGAAATAGATCTAACTTCCGAGGAGAAAGAGGTGGCTTTAGAGGGGGCCGTGGAGGAGCACACAGAGGTGGCTTTCCACCTCG ATAATTGTTGAAGACATTGAACCTATTCATCCTCCTCTAACCTTCTTTATTGTAATTAAATTTCAAGTGGGAGACTTAACTTTAGAACTC ACTTCCAGCTTGCACTTTGCTTTAATTTCTCTGAGCTGCAAGAATGTCTTAGCGAGCCTTGCTTGCAGTTGTCACACACACTGTCTGGTT TTTTTCAGGATAAATGAATGATTCTGCCTTTTGTTATGTGCGTGAACAGAATGGAACAACTCAAGTAGCTTCATCTTCAGAGACTGAATT TATTCTGATAGACTTCAGCTAATTACAAAGGATTTTGCTAATTTTTGGGAATAAATAATGGAAAAAGATCCAGTCTGTGGTATCATGCTA GTGCTGACAGGGCCTTGATAGAATAGAGTTGGAAAAGATGGTAAGCTTTTGTCAGGGTTTTAACATTTTCTTGATGAAACAATAAAAAGA GGTAAGCTTTTTTCTTCTTTTTTTTTAAGTTTTAAATAAACTCAGATATAATTTGAATACTGAAGAAATTAAGAGACTTTGAACAAAAAC TCTTCCCAAATCTAAATTTGATAGGGGAGGTGGAGATTCCAGGGGTGGGTGAAAGAAGAGATAGAACTTAGCAGGCAGACTTAAAAAAAA AAAAAAAGTTTATCATCATAATCTCAATTTTGTGGCTATGACTCCTAATCACGCTTCCTAAGAAGCAAAGGAGGACAAATATTCATGTGC TAGATAGCACTGTGGTGTGGACTTGAACTTGGATTGACCTTAAATTTTATATTCCTCAAATAAAAGAGAGGCAGCGACAAGATACCTCAT TATCAGATGCTTGGTTTATACATTTTGGGACTAAAATACTTGGTGATGAAATGACATACACCTTTAAACTTGTTATGGAGATAGTTTAAT GTAAAACCAACTACGGAAAACCCTCAACTTAAGGATACAGCTTGGAAATTGGAACTGCAATTGCCTTTTATTAAAACCATATGGTGTGAT GTTTGTTTTTAAAATTATATAAGACTTTATGCTGTCACTTCTCTTGCTGTACTGTAATTCATGTTTTAAATGAATTTGATAATGAAATTA TACTATTATCATTCTTGATGAATACTTTTCTTATTTTTATGATTTTTCTAATGAAACTTTAAACTTTTGAGATTTGAGAGTCTGTTTTCT ATAAGTAGAATTACTGTTGTTACAAAATGAAAAAGGACTGACCTAAAATCAGTCTCTTCTTTTGGTCTGTGATGGATTTTAATGGCCGTT CTGTGCTCATATATACCTAAGATGAGATTATATTACATCCACCAAAGACTCAGTTTGAAGATAAGGAATGAGTGATAGAAGAAATAAGGC TGAGATCCTTAAAAGCCTAATTAATTTAACTCGCTTAACCCATTAGTACTATCTAGTACAAGACCCCTTTTTTTTTGCTGAAATTATGGT ATATTTTCAACTTCACTAATTACAAATTATCTAGATTTAGAACTCTATATGTCAGCATTGACCTGGGAATGAAGTCAGGATAGAGAAATT CCACTTGCCTGTGATGGGTCCTTAGAAGTATCAGCTAAGGAGTGACCCTGTCCTATACACAGGGCTCTCTATTACGTTCCATACCCTGGG CCTACCCAAGGTGACATTCCTGCTGTTTACATGGCATAGGCACCTGTGAGATCAGTGTCACAATTTCATCTTAGAAAGAGGTAGGTATGG CTGCTTTGTCGGTTGAAAGTTAAGGGGAGCCATGATCTACCATATTTAGGAAAAAGTTATTTAAAAAAGAGCAGATGGTGGAAAAAGAAT GTAAGACCCAGAATTTATCCCTTTGACAATGAATCTGGCCTTTTTAATAGCAGGATGGAATTGATTCACTAGTTTTTGCTAACTTTCACT TTCAGTAAAGGTTGAGGTGTTGTTTTTGCAATGACTGTGTATTCATTGAGGAAAGGTTTCCAATGAAATTTCATTACTCTGACCTCTTCT AATTTTTGGTCTTCTTTATATTTACATGTCTTACATTCCACAAAATTATTTAGAAATGCTGGGCATGGTGGCTCATGCCTGTAATCCCAG CACTTTGTGAGGCCGATGTGGGTGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGACCAATATGGAGAAATCCCATCTCTACTAAAA ATACAAAATTAGCTGGGCGTGGTGGCATGTGCACGCCTGTAATCCCCGCTACTCGGGAGGCTGTGGCAGGAGAATTGCCTGAACCCAGGA GGCGGAGGTTGCAGTGAGCCGAGATTGTGCCACTGCACTCCAGCCTGGGCGACAGAGTGAGACTCTGTCTCAAAAAAAAAAAAAAAAATT GTATAGAAATAAATTTTTAGTTGCTTTATGCACTAATTCCTTACTGGGGATAGAAGCTAATTATTGTGAAATAACCTAGTTTAGAAGTTA GAAGATCAGCATGTCTGAGTTTTTACAGAATTATAATTCATGGTATTCCAAACCAACTGTTGTTATTTATTTCCAGTGAGAACCATTTTC CCACTGACCTTCCTCCTTTCAGAGGATGGGGATTAGGAGGCCCAAAGTACTGATTGAGTAGGAATACTTTTTTACTCTTCTTCACTGTGG AGAAAGAAGAGGGCAGGTAGTTGATGATGTCAGGAGAACAGATTTTATGGTGTGGAATACCATACCTAAACACAAATGAATCAGATTAGA CCACAGAATTGTGATGATGGCAGTCAGAATGTAATACGGTCATCATGAAACAGCACAGTGTGAGAGGTCAAGGTGTCAACCTGGGAAGTG AGAATCAAGCAGGAGTGTGGCATGGCAACCAACTCACAGATCCAGAGTTGAGAGGGATCACTACTGCAGCAGTTCTGCTCTGTTACTCTG GTAAGTAGTAGAGCCACTTTATGAGCCCTTATTTCCTATCTCCCTTATTCTGAGGCCAGGTCAGTGATATGCTATAGTTTCATTTAAGTT AATGGAGTATAAAGATGGGATACTTGGGAGCTATATTGTGCATCAGGGTGTCACAGCTGCTACTAGGAGTTACTCCTTTTCATGTCTTTT AAAATACTTTCTACCCATCTTAATTGCTAAATTATCTTTCAGTTAGTTACAGCGCTTAATTTAAAACCTGTACTGTTTTCATCCTGAATT TAGAACATAAGATTTAGCCTTTGAAGTATAGTTTCAGACTTTACTAATTTGTTTAATATAATCCTTATTAACATGACAAAATGAAAGCCC TGTTGGGACTTAGTCTAAACAGTAGTCTTTGATCTGAAAGTGTCTCATATTTTGTGATCTATTAGAAACATAAACCTTTGCTTATGCAGA AGGTCTTTCTTAGAACAATCCTGTAATCTTAGGGTTCATGTGTGACTAGCATTATCCTCTCTTTGATGTTGGGTAATAGAGGCTGAACTT TTCTTGTGTATATATAGTTAGTTTTGAGGCCATAAATCTAGGACTTCTCAAAAGATTAGAACATTTATCCAGTAAACTGACTCCATTGAA GACTTCATTTCTGGAAATACCACATTGCTTCTGCTCTCAATAACTCTATCATTTACTCGTATAAATATTGCTAGCTGTAATGCACAGAGA AAAACTACCTCATTCAATCTAGATAATTGGGACATCCTTTTCCAGTAAACCCTTTTTCCACTACTGGATAAAATATTAAAATGATCAGTT TGAGTGTATGTTAGAGTTCATGTTTCTGTAACTAAAGGTGCTAATAAACTGAAATCAGATAAGGTAGGTTTTTCCAAAAATACTTCTAAA TAATTGACAACCTAGAAGTCAACAATGTAAAATGCATATGGGACTCTATATTAATAGAGAAGCAGGCCAAGAACTTTTTAATGGGATAAT TGTCTTCTTTAGGCACATTGTTTGCATATTAACGACATGGAAATATTTTCACTCATTTACTTTCATCCATCTATCTGTGCTTTTTCTCAC TTTGATGAGTTCTCTCAACTCCTTTCTAAGAAAAGCAGAGCAGAGCAGCATAGAGTGCGTTAGTAAATGGCCACTGACTCTTGGTCTCAG GCCATAGCAACTATAGAGAGAAGAGTGGGGCTGGAGACCTCATACCCTGGGTAAAGTGGACATCACTTGTCAGCTCCAGCTAATTGTCAC CACAGAGAGAAGAGGGTAAGTCTGAGATGTTCATGTGCATTTCCCTACATTTTAGAGGTTGACAAAATAGTTTGTGACTTTTGCTTACAT TTGCATTCATAGAACTAAAAAAAATTTAACTTGGCTAACAAAATACCACATGCATATTTTCTTTTTTATTTTTATTTTTTGAGACAGAGT CTCTGTTACCCAGGCTGGGGGGCAGTGATAAGATCTTGGCTCACTGCAACCTCCGCCTCCAGGGTTGAAGCGATTCTTCTGCCTCAGCCT CCTGAGTAGCTGGAATTACAGGTGCCCACCACCACACCCAGCTAATTTTAGTATTCTTAGTAGAGACAGGATTTCACCATGTTGGCCAGG CTGGTCTCAAACTCCCGACCTCAACTGATCCACCCACCCTGGCCTCCCAAAGTGTCAGGATTACAGGCGTGAGCCTCTGCAACTGGCCAA CATGCATATTTAAATTATGCATGCATTGTAGCTGTATACTGTGTGACCACATTTACTTAAAAAAGAGGAAAAAAGGTTACTTGCTTGAGA CAGGAAACTATCACCTTTGAAAGCATATTAAGTAGTTGGCTTACTTTGGAACACACAGTAGACTGAAAATGTGAACTAATACTTTAAAAT TGCCGTATAATGATGTCATTGCAAGCCATTCATCTATCCAATGGGGGAAAATGTGGAGGTCTAGGCTTGTGTTGTCACAAAATACACCTT TTAGATAATCCTTACCTGTACAGATTTTTATAACTGTTGTTATCATAAGAGAATGGCTACATCATTATCCTGCCTTTTCTGGGTGTTTAT TTTGTTGTTTTTGAAAGTGGACAAAACCTCAAAGCACAATTTTGTTCTGATATATCCAGTTTAGTAGTTTATGCTGGTTAAATGATCAAA GTAATTGCTTAAATGTCTTGTGGAATTAGCTGTCACTTTATAGTTTATGTATTGTGGTGGGTACCTTAATAATAAAAAGATTTTTAATGT AATAATGGTGACCATCATCAAGGGGAAGGTGGAGGAGGTGGAGCTCCCAGTGGAGAAGGTGGACATCATCATCAGCGAGTGGATGGGCTA CTGCCTCTTCTACGAGTCCATGCTCAACACCGTGCTCTATGCCCGGGACAAGTGGCTGGCGCCCGATGGCCTCATCTTCCCAGACCGGGC CACGCTGTATGTGACGGCCATCGAGGACCGGCAGTACAAAGACTACAAGATCCACTGGTGGGAGAACGTGTATGGCTTCGACATGTCTTG CATCAAAGATGTGGCCATTAAGGAGCCCCTAGTGGATGTCGTGGACCCCAAACAGCTGGTCACCAACGCCTGCCTCATAAAGGAGGTGGA CATCTATACCGTCAAGGTGGAAGACCTGACCTTCACCTCCCCGTTCTGCCTGCAAGTGAAGCGGAATGACTACGTGCACGCCCTGGTGGC CTACTTCAACATCGAGTTCACACGCTGCCACAAGAGGACCGGCTTCTCCACCAGCCCCGAGTCCCCGTACACGCACTGGAAGCAGACGGT GTTCTACATGGAGGACTACCTGACCGTGAAGACGGGCGAGGAGATCTTCGGCACCATCGGCATGCGGCCCAACGCCAAGAACAACCGGGA CCTGGACTTCACCATCGACCTGGACTTCAAGGGCCAGCTGTGCGAGCTGTCCTGCTCCACCGACTACCGGATGCGCTGAGGCCCGGCTCT CCCGCCCTGCACGAGCCCAGGGGCTGAGCGTTCCTAGGCGGTTTCGGGGCTCCCCCTTCCTCTCCCTCCCTCCCGCAGAAGGGGGTTTTA GGGGCCTGGGCTGGGGGGATGGGGAGGGCACATCGTGACTGTGTTTTTCATAACTTATGTTTTTATATGGTTGCATTTACGCCAATAAAT >53055_53055_2_METTL14-PRMT1_METTL14_chr4_119631336_ENST00000388822_PRMT1_chr19_50187187_ENST00000454376_length(amino acids)=397AA_BP= MDSRLQEIRERQKLRRQLLAQQLGAESADSIGAVLNSKDEQREIAETRETCRASYDTSAPNAKRKYLDEGETDEDKMEEYKDELEMQQDE ENLPYEEEIYKDSSTFLKGTQSLNPHNDYCQHFVDTGHRPQNFIRDVGLADRFEEYPKLRELIRLKDELIAKSNTPPMYLQADIEAFDIR ELTPKFDVILLEPPLEEYYRETGITANEKCWTWDDIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPG KTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPEEVEL -------------------------------------------------------------- >53055_53055_3_METTL14-PRMT1_METTL14_chr4_119631336_ENST00000388822_PRMT1_chr19_50187187_ENST00000532489_length(transcript)=7391nt_BP=6485nt GCGAGCCAATTCCGGCCGCGCCGGAAGTCTCTACTGAGGAAAGCTATGAGGATACTCTGTTCGTAAGCTCCCGGTGAATTTTGTTCCACA GACTCGGAAGAAAGGTTGGATAAGAGTTCACTGGAGATTGACAAGTACTCGGGATAGTGAAAAGCCGGAGTTGGAACATGGATAGCCGCT TGCAGGAGATCCGGGAGCGGCAGAAGTTACGGCGACAGCTCCTCGCGCAGCAGTTGGGAGCTGAAAGTGCCGACAGCATTGGTGCCGTGT TAAATAGCAAAGATGAGCAGAGAGAAATTGCTGAAACAAGAGAAACTTGCAGGGCTTCCTATGATACCTCTGCTCCAAATGCAAAACGTA AGTATCTGGATGAAGGAGAGACAGATGAAGACAAAATGGAAGAATATAAGGATGAACTAGAAATGCAACAGGATGAAGAAAATTTGCCAT ATGAAGAAGAGATTTACAAAGATTCTAGTACTTTTCTTAAGGGAACACAGAGCTTAAATCCCCATAATGATTACTGCCAACATTTTGTAG ACACTGGACATAGACCTCAGAATTTCATCAGGGATGTAGGTTTAGCTGACAGATTTGAAGAATATCCTAAACTGAGGGAGCTCATCAGGC TAAAGGATGAGTTAATAGCTAAATCTAACACTCCTCCCATGTACTTACAAGCCGATATAGAAGCCTTTGACATCAGAGAACTAACACCCA AATTTGATGTGATTCTTCTGGAACCCCCTTTAGAAGAATATTACAGAGAAACTGGCATCACTGCTAATGAAAAATGCTGGACTTGGGATG ATATTATGAAGTTAGAAATTGATGAGATTGCAGCACCTCGATCATTTATTTTTCTCTGGTGTGGTTCTGGGGAGGGGTTGGACCTTGGAA GAGTGTGTTTACGAAAATGGGGTTACAGAAGATGTGAAGATATTTGTTGGATTAAAACCAATAAAAACAATCCTGGGAAGACTAAGACTT TAGATCCAAAGGCTGTCTTTCAGAGAACAAAGGAACACTGCCTCATGGGGATCAAAGGAACTGTGAAGCGTAGCACAGACGGGGACTTCA TTCATGCTAATGTTGACATTGACTTAATTATCACAGAAGAACCTGAAATTGGCAATATAGAAAAACCTGTAGAAATTTTTCATATAATTG AGCATTTTTGTCTTGGTAGAAGACGCCTTCATCTATTTGGAAGAGATAGTACAATTCGACCAGAAGAGGTGGAACTTCTGCTGGCCGTGG ACGAGAAAGAAATAGATCTAACTTCCGAGGAGAAAGAGGTGGCTTTAGAGGGGGCCGTGGAGGAGCACACAGAGGTGGCTTTCCACCTCG ATAATTGTTGAAGACATTGAACCTATTCATCCTCCTCTAACCTTCTTTATTGTAATTAAATTTCAAGTGGGAGACTTAACTTTAGAACTC ACTTCCAGCTTGCACTTTGCTTTAATTTCTCTGAGCTGCAAGAATGTCTTAGCGAGCCTTGCTTGCAGTTGTCACACACACTGTCTGGTT TTTTTCAGGATAAATGAATGATTCTGCCTTTTGTTATGTGCGTGAACAGAATGGAACAACTCAAGTAGCTTCATCTTCAGAGACTGAATT TATTCTGATAGACTTCAGCTAATTACAAAGGATTTTGCTAATTTTTGGGAATAAATAATGGAAAAAGATCCAGTCTGTGGTATCATGCTA GTGCTGACAGGGCCTTGATAGAATAGAGTTGGAAAAGATGGTAAGCTTTTGTCAGGGTTTTAACATTTTCTTGATGAAACAATAAAAAGA GGTAAGCTTTTTTCTTCTTTTTTTTTAAGTTTTAAATAAACTCAGATATAATTTGAATACTGAAGAAATTAAGAGACTTTGAACAAAAAC TCTTCCCAAATCTAAATTTGATAGGGGAGGTGGAGATTCCAGGGGTGGGTGAAAGAAGAGATAGAACTTAGCAGGCAGACTTAAAAAAAA AAAAAAAGTTTATCATCATAATCTCAATTTTGTGGCTATGACTCCTAATCACGCTTCCTAAGAAGCAAAGGAGGACAAATATTCATGTGC TAGATAGCACTGTGGTGTGGACTTGAACTTGGATTGACCTTAAATTTTATATTCCTCAAATAAAAGAGAGGCAGCGACAAGATACCTCAT TATCAGATGCTTGGTTTATACATTTTGGGACTAAAATACTTGGTGATGAAATGACATACACCTTTAAACTTGTTATGGAGATAGTTTAAT GTAAAACCAACTACGGAAAACCCTCAACTTAAGGATACAGCTTGGAAATTGGAACTGCAATTGCCTTTTATTAAAACCATATGGTGTGAT GTTTGTTTTTAAAATTATATAAGACTTTATGCTGTCACTTCTCTTGCTGTACTGTAATTCATGTTTTAAATGAATTTGATAATGAAATTA TACTATTATCATTCTTGATGAATACTTTTCTTATTTTTATGATTTTTCTAATGAAACTTTAAACTTTTGAGATTTGAGAGTCTGTTTTCT ATAAGTAGAATTACTGTTGTTACAAAATGAAAAAGGACTGACCTAAAATCAGTCTCTTCTTTTGGTCTGTGATGGATTTTAATGGCCGTT CTGTGCTCATATATACCTAAGATGAGATTATATTACATCCACCAAAGACTCAGTTTGAAGATAAGGAATGAGTGATAGAAGAAATAAGGC TGAGATCCTTAAAAGCCTAATTAATTTAACTCGCTTAACCCATTAGTACTATCTAGTACAAGACCCCTTTTTTTTTGCTGAAATTATGGT ATATTTTCAACTTCACTAATTACAAATTATCTAGATTTAGAACTCTATATGTCAGCATTGACCTGGGAATGAAGTCAGGATAGAGAAATT CCACTTGCCTGTGATGGGTCCTTAGAAGTATCAGCTAAGGAGTGACCCTGTCCTATACACAGGGCTCTCTATTACGTTCCATACCCTGGG CCTACCCAAGGTGACATTCCTGCTGTTTACATGGCATAGGCACCTGTGAGATCAGTGTCACAATTTCATCTTAGAAAGAGGTAGGTATGG CTGCTTTGTCGGTTGAAAGTTAAGGGGAGCCATGATCTACCATATTTAGGAAAAAGTTATTTAAAAAAGAGCAGATGGTGGAAAAAGAAT GTAAGACCCAGAATTTATCCCTTTGACAATGAATCTGGCCTTTTTAATAGCAGGATGGAATTGATTCACTAGTTTTTGCTAACTTTCACT TTCAGTAAAGGTTGAGGTGTTGTTTTTGCAATGACTGTGTATTCATTGAGGAAAGGTTTCCAATGAAATTTCATTACTCTGACCTCTTCT AATTTTTGGTCTTCTTTATATTTACATGTCTTACATTCCACAAAATTATTTAGAAATGCTGGGCATGGTGGCTCATGCCTGTAATCCCAG CACTTTGTGAGGCCGATGTGGGTGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGACCAATATGGAGAAATCCCATCTCTACTAAAA ATACAAAATTAGCTGGGCGTGGTGGCATGTGCACGCCTGTAATCCCCGCTACTCGGGAGGCTGTGGCAGGAGAATTGCCTGAACCCAGGA GGCGGAGGTTGCAGTGAGCCGAGATTGTGCCACTGCACTCCAGCCTGGGCGACAGAGTGAGACTCTGTCTCAAAAAAAAAAAAAAAAATT GTATAGAAATAAATTTTTAGTTGCTTTATGCACTAATTCCTTACTGGGGATAGAAGCTAATTATTGTGAAATAACCTAGTTTAGAAGTTA GAAGATCAGCATGTCTGAGTTTTTACAGAATTATAATTCATGGTATTCCAAACCAACTGTTGTTATTTATTTCCAGTGAGAACCATTTTC CCACTGACCTTCCTCCTTTCAGAGGATGGGGATTAGGAGGCCCAAAGTACTGATTGAGTAGGAATACTTTTTTACTCTTCTTCACTGTGG AGAAAGAAGAGGGCAGGTAGTTGATGATGTCAGGAGAACAGATTTTATGGTGTGGAATACCATACCTAAACACAAATGAATCAGATTAGA CCACAGAATTGTGATGATGGCAGTCAGAATGTAATACGGTCATCATGAAACAGCACAGTGTGAGAGGTCAAGGTGTCAACCTGGGAAGTG AGAATCAAGCAGGAGTGTGGCATGGCAACCAACTCACAGATCCAGAGTTGAGAGGGATCACTACTGCAGCAGTTCTGCTCTGTTACTCTG GTAAGTAGTAGAGCCACTTTATGAGCCCTTATTTCCTATCTCCCTTATTCTGAGGCCAGGTCAGTGATATGCTATAGTTTCATTTAAGTT AATGGAGTATAAAGATGGGATACTTGGGAGCTATATTGTGCATCAGGGTGTCACAGCTGCTACTAGGAGTTACTCCTTTTCATGTCTTTT AAAATACTTTCTACCCATCTTAATTGCTAAATTATCTTTCAGTTAGTTACAGCGCTTAATTTAAAACCTGTACTGTTTTCATCCTGAATT TAGAACATAAGATTTAGCCTTTGAAGTATAGTTTCAGACTTTACTAATTTGTTTAATATAATCCTTATTAACATGACAAAATGAAAGCCC TGTTGGGACTTAGTCTAAACAGTAGTCTTTGATCTGAAAGTGTCTCATATTTTGTGATCTATTAGAAACATAAACCTTTGCTTATGCAGA AGGTCTTTCTTAGAACAATCCTGTAATCTTAGGGTTCATGTGTGACTAGCATTATCCTCTCTTTGATGTTGGGTAATAGAGGCTGAACTT TTCTTGTGTATATATAGTTAGTTTTGAGGCCATAAATCTAGGACTTCTCAAAAGATTAGAACATTTATCCAGTAAACTGACTCCATTGAA GACTTCATTTCTGGAAATACCACATTGCTTCTGCTCTCAATAACTCTATCATTTACTCGTATAAATATTGCTAGCTGTAATGCACAGAGA AAAACTACCTCATTCAATCTAGATAATTGGGACATCCTTTTCCAGTAAACCCTTTTTCCACTACTGGATAAAATATTAAAATGATCAGTT TGAGTGTATGTTAGAGTTCATGTTTCTGTAACTAAAGGTGCTAATAAACTGAAATCAGATAAGGTAGGTTTTTCCAAAAATACTTCTAAA TAATTGACAACCTAGAAGTCAACAATGTAAAATGCATATGGGACTCTATATTAATAGAGAAGCAGGCCAAGAACTTTTTAATGGGATAAT TGTCTTCTTTAGGCACATTGTTTGCATATTAACGACATGGAAATATTTTCACTCATTTACTTTCATCCATCTATCTGTGCTTTTTCTCAC TTTGATGAGTTCTCTCAACTCCTTTCTAAGAAAAGCAGAGCAGAGCAGCATAGAGTGCGTTAGTAAATGGCCACTGACTCTTGGTCTCAG GCCATAGCAACTATAGAGAGAAGAGTGGGGCTGGAGACCTCATACCCTGGGTAAAGTGGACATCACTTGTCAGCTCCAGCTAATTGTCAC CACAGAGAGAAGAGGGTAAGTCTGAGATGTTCATGTGCATTTCCCTACATTTTAGAGGTTGACAAAATAGTTTGTGACTTTTGCTTACAT TTGCATTCATAGAACTAAAAAAAATTTAACTTGGCTAACAAAATACCACATGCATATTTTCTTTTTTATTTTTATTTTTTGAGACAGAGT CTCTGTTACCCAGGCTGGGGGGCAGTGATAAGATCTTGGCTCACTGCAACCTCCGCCTCCAGGGTTGAAGCGATTCTTCTGCCTCAGCCT CCTGAGTAGCTGGAATTACAGGTGCCCACCACCACACCCAGCTAATTTTAGTATTCTTAGTAGAGACAGGATTTCACCATGTTGGCCAGG CTGGTCTCAAACTCCCGACCTCAACTGATCCACCCACCCTGGCCTCCCAAAGTGTCAGGATTACAGGCGTGAGCCTCTGCAACTGGCCAA CATGCATATTTAAATTATGCATGCATTGTAGCTGTATACTGTGTGACCACATTTACTTAAAAAAGAGGAAAAAAGGTTACTTGCTTGAGA CAGGAAACTATCACCTTTGAAAGCATATTAAGTAGTTGGCTTACTTTGGAACACACAGTAGACTGAAAATGTGAACTAATACTTTAAAAT TGCCGTATAATGATGTCATTGCAAGCCATTCATCTATCCAATGGGGGAAAATGTGGAGGTCTAGGCTTGTGTTGTCACAAAATACACCTT TTAGATAATCCTTACCTGTACAGATTTTTATAACTGTTGTTATCATAAGAGAATGGCTACATCATTATCCTGCCTTTTCTGGGTGTTTAT TTTGTTGTTTTTGAAAGTGGACAAAACCTCAAAGCACAATTTTGTTCTGATATATCCAGTTTAGTAGTTTATGCTGGTTAAATGATCAAA GTAATTGCTTAAATGTCTTGTGGAATTAGCTGTCACTTTATAGTTTATGTATTGTGGTGGGTACCTTAATAATAAAAAGATTTTTAATGT AATAATGGTGACCATCATCAAGGGGAAGGTGGAGGAGGTGGAGCTCCCAGTGGAGAAGGTGGACATCATCATCAGCGAGTGGATGGGCTA CTGCCTCTTCTACGAGTCCATGCTCAACACCGTGCTCTATGCCCGGGACAAGTGGCTGGCGCCCGATGGCCTCATCTTCCCAGACCGGGC CACGCTGTATGTGACGGCCATCGAGGACCGGCAGTACAAAGACTACAAGATCCACTGGTGGGAGAACGTGTATGGCTTCGACATGTCTTG CATCAAAGATGTGGCCATTAAGGAGCCCCTAGTGGATGTCGTGGACCCCAAACAGCTGGTCACCAACGCCTGCCTCATAAAGGAGGTGGA CATCTATACCGTCAAGGTGGAAGACCTGACCTTCACCTCCCCGTTCTGCCTGCAAGTGAAGCGGAATGACTACGTGCACGCCCTGGTGGC CTACTTCAACATCGAGTTCACACGCTGCCACAAGAGGACCGGCTTCTCCACCAGCCCCGAGTCCCCGTACACGCACTGGAAGCAGACGGT GTTCTACATGGAGGACTACCTGACCGTGAAGACGGGCGAGGAGATCTTCGGCACCATCGGCATGCGGCCCAACGCCAAGAACAACCGGGA CCTGGACTTCACCATCGACCTGGACTTCAAGGGCCAGCTGTGCGAGCTGTCCTGCTCCACCGACTACCGGATGCGCTGAGGCCCGGCTCT CCCGCCCTGCACGAGCCCAGGGGCTGAGCGTTCCTAGGCGGTTTCGGGGCTCCCCCTTCCTCTCCCTCCCTCCCGCAGAAGGGGGTTTTA GGGGCCTGGGCTGGGGGGATGGGGAGGGCACATCGTGACTGTGTTTTTCATAACTTATGTTTTTATATGGTTGCATTTACGCCAATAAAT >53055_53055_3_METTL14-PRMT1_METTL14_chr4_119631336_ENST00000388822_PRMT1_chr19_50187187_ENST00000532489_length(amino acids)=397AA_BP= MDSRLQEIRERQKLRRQLLAQQLGAESADSIGAVLNSKDEQREIAETRETCRASYDTSAPNAKRKYLDEGETDEDKMEEYKDELEMQQDE ENLPYEEEIYKDSSTFLKGTQSLNPHNDYCQHFVDTGHRPQNFIRDVGLADRFEEYPKLRELIRLKDELIAKSNTPPMYLQADIEAFDIR ELTPKFDVILLEPPLEEYYRETGITANEKCWTWDDIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPG KTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPEEVEL -------------------------------------------------------------- >53055_53055_4_METTL14-PRMT1_METTL14_chr4_119631336_ENST00000506780_PRMT1_chr19_50187187_ENST00000391851_length(transcript)=2517nt_BP=1611nt ATGAGGATACTCTGTTCGTAAGCTCCCGGTGAATTTTGTTCCACAGACTCGGAAGAAAGGTTGGATAAGAGTTCACTGGAGATTGACAAG TACTCGGGATAGTGAAAAGCCGGAGTTGGAACATGGATAGCCGCTTGCAGGAGATCCGGGAGCGGCAGAAGTTACGGCGACAGCTCCTCG CGCAGCAGTTGGGAGCTGAAAGTGCCGACAGCATTGGTGCCGTGTTAAATAGCAAAGATGAGCAGAGAGAAATTGCTGAAACAAGAGAAA CTTGCAGGGCTTCCTATGATACCTCTGCTCCAAATGCAAAACGTAAGTATCTGGATGAAGGAGAGACAGATGAAGACAAAATGGAAGAAT ATAAGGCAAGTAGAGAAAATGCAACAGGATGAAGAAAATTTGCCATATGAAGAAGAGATTTACAAAGATTCTAGTACTTTTCTTAAGGGA ACACAGAGCTTAAATCCCCATAATGATTACTGCCAACATTTTGTAGACACTGGACATAGACCTCAGAATTTCATCAGGGATGTAGGTTTA GCTGACAGATTTGAAGAATATCCTAAACTGAGGGAGCTCATCAGGCTAAAGGATGAGTTAATAGCTAAATCTAACACTCCTCCCATGTAC TTACAAGCCGATATAGAAGCCTTTGACATCAGAGAACTAACACCCAAATTTGATGTGATTCTTCTGGAACCCCCTTTAGAAGAATATTAC AGAGAAACTGGCATCACTGCTAATGAAAAATGCTGGACTTGGGATGATATTATGAAGTTAGAAATTGATGAGATTGCAGCACCTCGATCA TTTATTTTTCTCTGGTGTGGTTCTGGGGAGGGGTTGGACCTTGGAAGAGTGTGTTTACGAAAATGGGGTTACAGAAGATGTGAAGATATT TGTTGGATTAAAACCAATAAAAACAATCCTGGGAAGACTAAGACTTTAGATCCAAAGGCTGTCTTTCAGAGAACAAAGGAACACTGCCTC ATGGGGATCAAAGGAACTGTGAAGCGTAGCACAGACGGGGACTTCATTCATGCTAATGTTGACATTGACTTAATTATCACAGAAGAACCT GAAATTGGCAATATAGAAAAACCTGTAGAAATTTTTCATATAATTGAGCATTTTTGTCTTGGTAGAAGACGCCTTCATCTATTTGGAAGA GATAGTACAATTCGACCAGAAGAGGTGGAACTTCTGCTGGCCGTGGACGAGAAAGAAATAGATCTAACTTCCGAGGAGAAAGAGGTGGCT TTAGAGGGGGCCGTGGAGGAGCACACAGAGGTGGCTTTCCACCTCGATAATTGTTGAAGACATTGAACCTATTCATCCTCCTCTAACCTT CTTTATTGTAATTAAATTTCAAGTGGGAGACTTAACTTTAGAACTCACTTCCAGCTTGCACTTTGCTTTAATTTCTCTGAGCTGCAAGAA TGTCTTAGCGAGCCTTGCTTGCAGTTGTCACACACACTGTCTGGTTTTTTTCAGGATAAATGAATGATTCTGCCTTTTGTTATGTGCGTG AACAGAATGGAACAACTCAAGTAGCTTCATCTTCAGAGACTGAATTTATTCTGATAGACTTCAGCTAATTACAAAGGATTTTGGTGACCA TCATCAAGGGGAAGGTGGAGGAGGTGGAGCTCCCAGTGGAGAAGGTGGACATCATCATCAGCGAGTGGATGGGCTACTGCCTCTTCTACG AGTCCATGCTCAACACCGTGCTCTATGCCCGGGACAAGTGGCTGGCGCCCGATGGCCTCATCTTCCCAGACCGGGCCACGCTGTATGTGA CGGCCATCGAGGACCGGCAGTACAAAGACTACAAGATCCACTGGTGGGAGAACGTGTATGGCTTCGACATGTCTTGCATCAAAGATGTGG CCATTAAGGAGCCCCTAGTGGATGTCGTGGACCCCAAACAGCTGGTCACCAACGCCTGCCTCATAAAGGAGGTGGACATCTATACCGTCA AGGTGGAAGACCTGACCTTCACCTCCCCGTTCTGCCTGCAAGTGAAGCGGAATGACTACGTGCACGCCCTGGTGGCCTACTTCAACATCG AGTTCACACGCTGCCACAAGAGGACCGGCTTCTCCACCAGCCCCGAGTCCCCGTACACGCACTGGAAGCAGACGGTGTTCTACATGGAGG ACTACCTGACCGTGAAGACGGGCGAGGAGATCTTCGGCACCATCGGCATGCGGCCCAACGCCAAGAACAACCGGGACCTGGACTTCACCA TCGACCTGGACTTCAAGGGCCAGCTGTGCGAGCTGTCCTGCTCCACCGACTACCGGATGCGCTGAGGCCCGGCTCTCCCGCCCTGCACGA GCCCAGGGGCTGAGCGTTCCTAGGCGGTTTCGGGGCTCCCCCTTCCTCTCCCTCCCTCCCGCAGAAGGGGGTTTTAGGGGCCTGGGCTGG >53055_53055_4_METTL14-PRMT1_METTL14_chr4_119631336_ENST00000506780_PRMT1_chr19_50187187_ENST00000391851_length(amino acids)=359AA_BP= MSREKLLKQEKLAGLPMIPLLQMQNVSIWMKERQMKTKWKNIRQVEKMQQDEENLPYEEEIYKDSSTFLKGTQSLNPHNDYCQHFVDTGH RPQNFIRDVGLADRFEEYPKLRELIRLKDELIAKSNTPPMYLQADIEAFDIRELTPKFDVILLEPPLEEYYRETGITANEKCWTWDDIMK LEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPGKTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHAN -------------------------------------------------------------- >53055_53055_5_METTL14-PRMT1_METTL14_chr4_119631336_ENST00000506780_PRMT1_chr19_50187187_ENST00000454376_length(transcript)=2517nt_BP=1611nt ATGAGGATACTCTGTTCGTAAGCTCCCGGTGAATTTTGTTCCACAGACTCGGAAGAAAGGTTGGATAAGAGTTCACTGGAGATTGACAAG TACTCGGGATAGTGAAAAGCCGGAGTTGGAACATGGATAGCCGCTTGCAGGAGATCCGGGAGCGGCAGAAGTTACGGCGACAGCTCCTCG CGCAGCAGTTGGGAGCTGAAAGTGCCGACAGCATTGGTGCCGTGTTAAATAGCAAAGATGAGCAGAGAGAAATTGCTGAAACAAGAGAAA CTTGCAGGGCTTCCTATGATACCTCTGCTCCAAATGCAAAACGTAAGTATCTGGATGAAGGAGAGACAGATGAAGACAAAATGGAAGAAT ATAAGGCAAGTAGAGAAAATGCAACAGGATGAAGAAAATTTGCCATATGAAGAAGAGATTTACAAAGATTCTAGTACTTTTCTTAAGGGA ACACAGAGCTTAAATCCCCATAATGATTACTGCCAACATTTTGTAGACACTGGACATAGACCTCAGAATTTCATCAGGGATGTAGGTTTA GCTGACAGATTTGAAGAATATCCTAAACTGAGGGAGCTCATCAGGCTAAAGGATGAGTTAATAGCTAAATCTAACACTCCTCCCATGTAC TTACAAGCCGATATAGAAGCCTTTGACATCAGAGAACTAACACCCAAATTTGATGTGATTCTTCTGGAACCCCCTTTAGAAGAATATTAC AGAGAAACTGGCATCACTGCTAATGAAAAATGCTGGACTTGGGATGATATTATGAAGTTAGAAATTGATGAGATTGCAGCACCTCGATCA TTTATTTTTCTCTGGTGTGGTTCTGGGGAGGGGTTGGACCTTGGAAGAGTGTGTTTACGAAAATGGGGTTACAGAAGATGTGAAGATATT TGTTGGATTAAAACCAATAAAAACAATCCTGGGAAGACTAAGACTTTAGATCCAAAGGCTGTCTTTCAGAGAACAAAGGAACACTGCCTC ATGGGGATCAAAGGAACTGTGAAGCGTAGCACAGACGGGGACTTCATTCATGCTAATGTTGACATTGACTTAATTATCACAGAAGAACCT GAAATTGGCAATATAGAAAAACCTGTAGAAATTTTTCATATAATTGAGCATTTTTGTCTTGGTAGAAGACGCCTTCATCTATTTGGAAGA GATAGTACAATTCGACCAGAAGAGGTGGAACTTCTGCTGGCCGTGGACGAGAAAGAAATAGATCTAACTTCCGAGGAGAAAGAGGTGGCT TTAGAGGGGGCCGTGGAGGAGCACACAGAGGTGGCTTTCCACCTCGATAATTGTTGAAGACATTGAACCTATTCATCCTCCTCTAACCTT CTTTATTGTAATTAAATTTCAAGTGGGAGACTTAACTTTAGAACTCACTTCCAGCTTGCACTTTGCTTTAATTTCTCTGAGCTGCAAGAA TGTCTTAGCGAGCCTTGCTTGCAGTTGTCACACACACTGTCTGGTTTTTTTCAGGATAAATGAATGATTCTGCCTTTTGTTATGTGCGTG AACAGAATGGAACAACTCAAGTAGCTTCATCTTCAGAGACTGAATTTATTCTGATAGACTTCAGCTAATTACAAAGGATTTTGGTGACCA TCATCAAGGGGAAGGTGGAGGAGGTGGAGCTCCCAGTGGAGAAGGTGGACATCATCATCAGCGAGTGGATGGGCTACTGCCTCTTCTACG AGTCCATGCTCAACACCGTGCTCTATGCCCGGGACAAGTGGCTGGCGCCCGATGGCCTCATCTTCCCAGACCGGGCCACGCTGTATGTGA CGGCCATCGAGGACCGGCAGTACAAAGACTACAAGATCCACTGGTGGGAGAACGTGTATGGCTTCGACATGTCTTGCATCAAAGATGTGG CCATTAAGGAGCCCCTAGTGGATGTCGTGGACCCCAAACAGCTGGTCACCAACGCCTGCCTCATAAAGGAGGTGGACATCTATACCGTCA AGGTGGAAGACCTGACCTTCACCTCCCCGTTCTGCCTGCAAGTGAAGCGGAATGACTACGTGCACGCCCTGGTGGCCTACTTCAACATCG AGTTCACACGCTGCCACAAGAGGACCGGCTTCTCCACCAGCCCCGAGTCCCCGTACACGCACTGGAAGCAGACGGTGTTCTACATGGAGG ACTACCTGACCGTGAAGACGGGCGAGGAGATCTTCGGCACCATCGGCATGCGGCCCAACGCCAAGAACAACCGGGACCTGGACTTCACCA TCGACCTGGACTTCAAGGGCCAGCTGTGCGAGCTGTCCTGCTCCACCGACTACCGGATGCGCTGAGGCCCGGCTCTCCCGCCCTGCACGA GCCCAGGGGCTGAGCGTTCCTAGGCGGTTTCGGGGCTCCCCCTTCCTCTCCCTCCCTCCCGCAGAAGGGGGTTTTAGGGGCCTGGGCTGG >53055_53055_5_METTL14-PRMT1_METTL14_chr4_119631336_ENST00000506780_PRMT1_chr19_50187187_ENST00000454376_length(amino acids)=359AA_BP= MSREKLLKQEKLAGLPMIPLLQMQNVSIWMKERQMKTKWKNIRQVEKMQQDEENLPYEEEIYKDSSTFLKGTQSLNPHNDYCQHFVDTGH RPQNFIRDVGLADRFEEYPKLRELIRLKDELIAKSNTPPMYLQADIEAFDIRELTPKFDVILLEPPLEEYYRETGITANEKCWTWDDIMK LEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPGKTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHAN -------------------------------------------------------------- >53055_53055_6_METTL14-PRMT1_METTL14_chr4_119631336_ENST00000506780_PRMT1_chr19_50187187_ENST00000532489_length(transcript)=2517nt_BP=1611nt ATGAGGATACTCTGTTCGTAAGCTCCCGGTGAATTTTGTTCCACAGACTCGGAAGAAAGGTTGGATAAGAGTTCACTGGAGATTGACAAG TACTCGGGATAGTGAAAAGCCGGAGTTGGAACATGGATAGCCGCTTGCAGGAGATCCGGGAGCGGCAGAAGTTACGGCGACAGCTCCTCG CGCAGCAGTTGGGAGCTGAAAGTGCCGACAGCATTGGTGCCGTGTTAAATAGCAAAGATGAGCAGAGAGAAATTGCTGAAACAAGAGAAA CTTGCAGGGCTTCCTATGATACCTCTGCTCCAAATGCAAAACGTAAGTATCTGGATGAAGGAGAGACAGATGAAGACAAAATGGAAGAAT ATAAGGCAAGTAGAGAAAATGCAACAGGATGAAGAAAATTTGCCATATGAAGAAGAGATTTACAAAGATTCTAGTACTTTTCTTAAGGGA ACACAGAGCTTAAATCCCCATAATGATTACTGCCAACATTTTGTAGACACTGGACATAGACCTCAGAATTTCATCAGGGATGTAGGTTTA GCTGACAGATTTGAAGAATATCCTAAACTGAGGGAGCTCATCAGGCTAAAGGATGAGTTAATAGCTAAATCTAACACTCCTCCCATGTAC TTACAAGCCGATATAGAAGCCTTTGACATCAGAGAACTAACACCCAAATTTGATGTGATTCTTCTGGAACCCCCTTTAGAAGAATATTAC AGAGAAACTGGCATCACTGCTAATGAAAAATGCTGGACTTGGGATGATATTATGAAGTTAGAAATTGATGAGATTGCAGCACCTCGATCA TTTATTTTTCTCTGGTGTGGTTCTGGGGAGGGGTTGGACCTTGGAAGAGTGTGTTTACGAAAATGGGGTTACAGAAGATGTGAAGATATT TGTTGGATTAAAACCAATAAAAACAATCCTGGGAAGACTAAGACTTTAGATCCAAAGGCTGTCTTTCAGAGAACAAAGGAACACTGCCTC ATGGGGATCAAAGGAACTGTGAAGCGTAGCACAGACGGGGACTTCATTCATGCTAATGTTGACATTGACTTAATTATCACAGAAGAACCT GAAATTGGCAATATAGAAAAACCTGTAGAAATTTTTCATATAATTGAGCATTTTTGTCTTGGTAGAAGACGCCTTCATCTATTTGGAAGA GATAGTACAATTCGACCAGAAGAGGTGGAACTTCTGCTGGCCGTGGACGAGAAAGAAATAGATCTAACTTCCGAGGAGAAAGAGGTGGCT TTAGAGGGGGCCGTGGAGGAGCACACAGAGGTGGCTTTCCACCTCGATAATTGTTGAAGACATTGAACCTATTCATCCTCCTCTAACCTT CTTTATTGTAATTAAATTTCAAGTGGGAGACTTAACTTTAGAACTCACTTCCAGCTTGCACTTTGCTTTAATTTCTCTGAGCTGCAAGAA TGTCTTAGCGAGCCTTGCTTGCAGTTGTCACACACACTGTCTGGTTTTTTTCAGGATAAATGAATGATTCTGCCTTTTGTTATGTGCGTG AACAGAATGGAACAACTCAAGTAGCTTCATCTTCAGAGACTGAATTTATTCTGATAGACTTCAGCTAATTACAAAGGATTTTGGTGACCA TCATCAAGGGGAAGGTGGAGGAGGTGGAGCTCCCAGTGGAGAAGGTGGACATCATCATCAGCGAGTGGATGGGCTACTGCCTCTTCTACG AGTCCATGCTCAACACCGTGCTCTATGCCCGGGACAAGTGGCTGGCGCCCGATGGCCTCATCTTCCCAGACCGGGCCACGCTGTATGTGA CGGCCATCGAGGACCGGCAGTACAAAGACTACAAGATCCACTGGTGGGAGAACGTGTATGGCTTCGACATGTCTTGCATCAAAGATGTGG CCATTAAGGAGCCCCTAGTGGATGTCGTGGACCCCAAACAGCTGGTCACCAACGCCTGCCTCATAAAGGAGGTGGACATCTATACCGTCA AGGTGGAAGACCTGACCTTCACCTCCCCGTTCTGCCTGCAAGTGAAGCGGAATGACTACGTGCACGCCCTGGTGGCCTACTTCAACATCG AGTTCACACGCTGCCACAAGAGGACCGGCTTCTCCACCAGCCCCGAGTCCCCGTACACGCACTGGAAGCAGACGGTGTTCTACATGGAGG ACTACCTGACCGTGAAGACGGGCGAGGAGATCTTCGGCACCATCGGCATGCGGCCCAACGCCAAGAACAACCGGGACCTGGACTTCACCA TCGACCTGGACTTCAAGGGCCAGCTGTGCGAGCTGTCCTGCTCCACCGACTACCGGATGCGCTGAGGCCCGGCTCTCCCGCCCTGCACGA GCCCAGGGGCTGAGCGTTCCTAGGCGGTTTCGGGGCTCCCCCTTCCTCTCCCTCCCTCCCGCAGAAGGGGGTTTTAGGGGCCTGGGCTGG >53055_53055_6_METTL14-PRMT1_METTL14_chr4_119631336_ENST00000506780_PRMT1_chr19_50187187_ENST00000532489_length(amino acids)=359AA_BP= MSREKLLKQEKLAGLPMIPLLQMQNVSIWMKERQMKTKWKNIRQVEKMQQDEENLPYEEEIYKDSSTFLKGTQSLNPHNDYCQHFVDTGH RPQNFIRDVGLADRFEEYPKLRELIRLKDELIAKSNTPPMYLQADIEAFDIRELTPKFDVILLEPPLEEYYRETGITANEKCWTWDDIMK LEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPGKTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHAN -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for METTL14-PRMT1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | METTL14 | chr4:119631336 | chr19:50187187 | ENST00000388822 | + | 1 | 11 | 135_136 | 0 | 457.0 | METTL3 |
| Hgene | METTL14 | chr4:119631336 | chr19:50187187 | ENST00000388822 | + | 1 | 11 | 237_238 | 0 | 457.0 | METTL3 |
| Hgene | METTL14 | chr4:119631336 | chr19:50187187 | ENST00000388822 | + | 1 | 11 | 255_258 | 0 | 457.0 | METTL3 |
| Hgene | METTL14 | chr4:119631336 | chr19:50187187 | ENST00000388822 | + | 1 | 11 | 278_287 | 0 | 457.0 | METTL3 |
| Hgene | METTL14 | chr4:119631336 | chr19:50187187 | ENST00000388822 | + | 1 | 11 | 308_312 | 0 | 457.0 | METTL3 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for METTL14-PRMT1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for METTL14-PRMT1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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