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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:METTL23-METTL23 (FusionGDB2 ID:53103)

Fusion Gene Summary for METTL23-METTL23

Fusion gene summary

Fusion gene information	Fusion gene name: METTL23-METTL23
	Fusion gene ID: 53103
		Hgene	Tgene
	Gene symbol	METTL23	METTL23
	Gene ID	124512	124512
	Gene name	methyltransferase like 23	methyltransferase like 23
	Synonyms	C17orf95\|MRT44	C17orf95\|MRT44
	Cytomap	17q25.1	17q25.1
	Type of gene	protein-coding	protein-coding
	Description	methyltransferase-like protein 23spike binding protein 1	methyltransferase-like protein 23spike binding protein 1
	Modification date	20200313	20200313
	UniProtAcc	Q86XA0	Q86XA0
	Ensembl transtripts involved in fusion gene	ENST00000586738, ENST00000588302, ENST00000588783, ENST00000591571, ENST00000341249, ENST00000586200, ENST00000586752, ENST00000588822, ENST00000590964, ENST00000589977,	ENST00000341249, ENST00000586200, ENST00000586738, ENST00000586752, ENST00000588302, ENST00000588783, ENST00000588822, ENST00000589977, ENST00000590964, ENST00000591571,
Fusion gene scores	* DoF score	3 X 5 X 3=45	5 X 9 X 3=135
	# samples	5	6
	** MAII score	log2(5/45*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(6/135*10)=-1.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: METTL23 [Title/Abstract] AND METTL23 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	METTL23(74727819)-METTL23(74727971), # samples:1 METTL23(74729637)-METTL23(74729420), # samples:1
Anticipated loss of major functional domain due to fusion event.	METTL23-METTL23 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. METTL23-METTL23 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across METTL23 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across METTL23 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BF825543	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
ChiTaRS5.0	N/A	BU689941	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+

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Fusion Gene ORF analysis for METTL23-METTL23

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000586738	ENST00000341249	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000586738	ENST00000586200	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000586738	ENST00000586738	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000586738	ENST00000586752	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000586738	ENST00000588302	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000586738	ENST00000588783	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000586738	ENST00000588822	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000586738	ENST00000589977	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000586738	ENST00000590964	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000586738	ENST00000591571	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000588302	ENST00000341249	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000588302	ENST00000586200	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000588302	ENST00000586738	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000588302	ENST00000586752	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000588302	ENST00000588302	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000588302	ENST00000588783	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000588302	ENST00000588822	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000588302	ENST00000589977	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000588302	ENST00000590964	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000588302	ENST00000591571	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000588783	ENST00000341249	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000588783	ENST00000586200	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000588783	ENST00000586738	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000588783	ENST00000586752	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000588783	ENST00000588302	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000588783	ENST00000588783	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000588783	ENST00000588822	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000588783	ENST00000589977	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000588783	ENST00000590964	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000588783	ENST00000591571	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000591571	ENST00000341249	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000591571	ENST00000586200	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000591571	ENST00000586738	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000591571	ENST00000586752	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000591571	ENST00000588302	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000591571	ENST00000588783	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000591571	ENST00000588822	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000591571	ENST00000589977	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000591571	ENST00000590964	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
3UTR-3CDS	ENST00000591571	ENST00000591571	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000341249	ENST00000589977	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000341249	ENST00000591571	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000586200	ENST00000341249	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000586200	ENST00000586200	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000586200	ENST00000586738	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000586200	ENST00000586752	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000586200	ENST00000588302	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000586200	ENST00000588783	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000586200	ENST00000588822	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000586200	ENST00000590964	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000586200	ENST00000591571	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000586752	ENST00000589977	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000586752	ENST00000591571	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000588822	ENST00000341249	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000588822	ENST00000586200	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000588822	ENST00000586738	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000588822	ENST00000586752	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000588822	ENST00000588302	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000588822	ENST00000588783	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000588822	ENST00000588822	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000588822	ENST00000590964	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000588822	ENST00000591571	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000590964	ENST00000341249	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000590964	ENST00000586200	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000590964	ENST00000586738	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000590964	ENST00000586752	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000590964	ENST00000588302	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000590964	ENST00000588783	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000590964	ENST00000588822	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000590964	ENST00000590964	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
Frame-shift	ENST00000590964	ENST00000591571	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
In-frame	ENST00000341249	ENST00000341249	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
In-frame	ENST00000341249	ENST00000586200	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
In-frame	ENST00000341249	ENST00000586738	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
In-frame	ENST00000341249	ENST00000586752	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
In-frame	ENST00000341249	ENST00000588302	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
In-frame	ENST00000341249	ENST00000588783	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
In-frame	ENST00000341249	ENST00000588822	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
In-frame	ENST00000341249	ENST00000590964	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
In-frame	ENST00000586200	ENST00000589977	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
In-frame	ENST00000586752	ENST00000341249	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
In-frame	ENST00000586752	ENST00000586200	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
In-frame	ENST00000586752	ENST00000586738	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
In-frame	ENST00000586752	ENST00000586752	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
In-frame	ENST00000586752	ENST00000588302	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
In-frame	ENST00000586752	ENST00000588783	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
In-frame	ENST00000586752	ENST00000588822	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
In-frame	ENST00000586752	ENST00000590964	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
In-frame	ENST00000588822	ENST00000589977	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
In-frame	ENST00000590964	ENST00000589977	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
intron-3CDS	ENST00000589977	ENST00000341249	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
intron-3CDS	ENST00000589977	ENST00000586200	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
intron-3CDS	ENST00000589977	ENST00000586738	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
intron-3CDS	ENST00000589977	ENST00000586752	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
intron-3CDS	ENST00000589977	ENST00000588302	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
intron-3CDS	ENST00000589977	ENST00000588783	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
intron-3CDS	ENST00000589977	ENST00000588822	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
intron-3CDS	ENST00000589977	ENST00000589977	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
intron-3CDS	ENST00000589977	ENST00000590964	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
intron-3CDS	ENST00000589977	ENST00000591571	METTL23	chr17	74729637	-	METTL23	chr17	74729420	+
intron-intron	ENST00000341249	ENST00000341249	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000341249	ENST00000586200	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000341249	ENST00000586738	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000341249	ENST00000586752	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000341249	ENST00000588302	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000341249	ENST00000588783	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000341249	ENST00000588822	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000341249	ENST00000589977	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000341249	ENST00000590964	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000341249	ENST00000591571	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586200	ENST00000341249	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586200	ENST00000586200	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586200	ENST00000586738	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586200	ENST00000586752	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586200	ENST00000588302	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586200	ENST00000588783	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586200	ENST00000588822	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586200	ENST00000589977	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586200	ENST00000590964	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586200	ENST00000591571	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586738	ENST00000341249	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586738	ENST00000586200	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586738	ENST00000586738	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586738	ENST00000586752	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586738	ENST00000588302	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586738	ENST00000588783	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586738	ENST00000588822	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586738	ENST00000589977	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586738	ENST00000590964	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586738	ENST00000591571	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586752	ENST00000341249	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586752	ENST00000586200	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586752	ENST00000586738	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586752	ENST00000586752	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586752	ENST00000588302	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586752	ENST00000588783	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586752	ENST00000588822	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586752	ENST00000589977	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586752	ENST00000590964	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000586752	ENST00000591571	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588302	ENST00000341249	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588302	ENST00000586200	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588302	ENST00000586738	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588302	ENST00000586752	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588302	ENST00000588302	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588302	ENST00000588783	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588302	ENST00000588822	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588302	ENST00000589977	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588302	ENST00000590964	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588302	ENST00000591571	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588783	ENST00000341249	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588783	ENST00000586200	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588783	ENST00000586738	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588783	ENST00000586752	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588783	ENST00000588302	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588783	ENST00000588783	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588783	ENST00000588822	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588783	ENST00000589977	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588783	ENST00000590964	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588783	ENST00000591571	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588822	ENST00000341249	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588822	ENST00000586200	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588822	ENST00000586738	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588822	ENST00000586752	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588822	ENST00000588302	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588822	ENST00000588783	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588822	ENST00000588822	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588822	ENST00000589977	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588822	ENST00000590964	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000588822	ENST00000591571	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000589977	ENST00000341249	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000589977	ENST00000586200	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000589977	ENST00000586738	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000589977	ENST00000586752	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000589977	ENST00000588302	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000589977	ENST00000588783	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000589977	ENST00000588822	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000589977	ENST00000589977	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000589977	ENST00000590964	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000589977	ENST00000591571	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000590964	ENST00000341249	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000590964	ENST00000586200	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000590964	ENST00000586738	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000590964	ENST00000586752	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000590964	ENST00000588302	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000590964	ENST00000588783	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000590964	ENST00000588822	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000590964	ENST00000589977	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000590964	ENST00000590964	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000590964	ENST00000591571	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000591571	ENST00000341249	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000591571	ENST00000586200	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000591571	ENST00000586738	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000591571	ENST00000586752	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000591571	ENST00000588302	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000591571	ENST00000588783	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000591571	ENST00000588822	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000591571	ENST00000589977	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000591571	ENST00000590964	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+
intron-intron	ENST00000591571	ENST00000591571	METTL23	chr17	74727819	-	METTL23	chr17	74727971	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for METTL23-METTL23

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for METTL23-METTL23

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:74727819/chr17:74727971)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
METTL23 Q86XA0	METTL23 Q86XA0
FUNCTION: Probable methyltransferase. {ECO:0000250}.	FUNCTION: Probable methyltransferase. {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

METTL23

chr17:74729637

chr17:74729420

ENST00000341249

29_45

191.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

METTL23

chr17:74729637

chr17:74729420

ENST00000341249

29_45

191.0

Transmembrane

Helical

Top

Fusion Gene Sequence for METTL23-METTL23

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for METTL23-METTL23

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for METTL23-METTL23

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for METTL23-METTL23

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source