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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:METTL4-STXBP5L (FusionGDB2 ID:53133)

Fusion Gene Summary for METTL4-STXBP5L

Fusion gene summary

Fusion gene information	Fusion gene name: METTL4-STXBP5L
	Fusion gene ID: 53133
		Hgene	Tgene
	Gene symbol	METTL4	STXBP5L
	Gene ID	64863	9515
	Gene name	methyltransferase like 4	syntaxin binding protein 5 like
	Synonyms	HsT661	LLGL4
	Cytomap	18p11.32	3q13.33
	Type of gene	protein-coding	protein-coding
	Description	N(6)-adenine-specific DNA methyltransferase METTL4methyltransferase-like protein 4	syntaxin-binding protein 5-likelethal(2) giant larvae protein homolog 4tomosyn-2tomosyn-like
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000574538, ENST00000319888,	ENST00000273666, ENST00000471454, ENST00000472879, ENST00000492541, ENST00000497029,
Fusion gene scores	* DoF score	2 X 2 X 2=8	4 X 4 X 3=48
	# samples	2	4
	** MAII score	log2(2/8*10)=1.32192809488736	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: METTL4 [Title/Abstract] AND STXBP5L [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	METTL4(2544194)-STXBP5L(120941850), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across METTL4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across STXBP5L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-NC-A5HL-01A	METTL4	chr18	2544194	-	STXBP5L	chr3	120941850	+
ChimerDB4	LUSC	TCGA-NC-A5HL	METTL4	chr18	2544194	-	STXBP5L	chr3	120941850	+

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Fusion Gene ORF analysis for METTL4-STXBP5L

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000574538	ENST00000273666	METTL4	chr18	2544194	-	STXBP5L	chr3	120941850	+
In-frame	ENST00000574538	ENST00000471454	METTL4	chr18	2544194	-	STXBP5L	chr3	120941850	+
In-frame	ENST00000574538	ENST00000472879	METTL4	chr18	2544194	-	STXBP5L	chr3	120941850	+
In-frame	ENST00000574538	ENST00000492541	METTL4	chr18	2544194	-	STXBP5L	chr3	120941850	+
In-frame	ENST00000574538	ENST00000497029	METTL4	chr18	2544194	-	STXBP5L	chr3	120941850	+
intron-3CDS	ENST00000319888	ENST00000273666	METTL4	chr18	2544194	-	STXBP5L	chr3	120941850	+
intron-3CDS	ENST00000319888	ENST00000471454	METTL4	chr18	2544194	-	STXBP5L	chr3	120941850	+
intron-3CDS	ENST00000319888	ENST00000472879	METTL4	chr18	2544194	-	STXBP5L	chr3	120941850	+
intron-3CDS	ENST00000319888	ENST00000492541	METTL4	chr18	2544194	-	STXBP5L	chr3	120941850	+
intron-3CDS	ENST00000319888	ENST00000497029	METTL4	chr18	2544194	-	STXBP5L	chr3	120941850	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000574538	METTL4	chr18	2544194	-	ENST00000273666	STXBP5L	chr3	120941850	+	10318	2049	2077	4653	858
ENST00000574538	METTL4	chr18	2544194	-	ENST00000471454	STXBP5L	chr3	120941850	+	4768	2049	2077	4581	834
ENST00000574538	METTL4	chr18	2544194	-	ENST00000472879	STXBP5L	chr3	120941850	+	4106	2049	2077	4101	674
ENST00000574538	METTL4	chr18	2544194	-	ENST00000497029	STXBP5L	chr3	120941850	+	4100	2049	2077	4095	672
ENST00000574538	METTL4	chr18	2544194	-	ENST00000492541	STXBP5L	chr3	120941850	+	4178	2049	2077	4173	698

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000574538	ENST00000273666	METTL4	chr18	2544194	-	STXBP5L	chr3	120941850	+	0.001652274	0.99834776
ENST00000574538	ENST00000471454	METTL4	chr18	2544194	-	STXBP5L	chr3	120941850	+	0.002824329	0.9971757
ENST00000574538	ENST00000472879	METTL4	chr18	2544194	-	STXBP5L	chr3	120941850	+	0.002819891	0.9971801
ENST00000574538	ENST00000497029	METTL4	chr18	2544194	-	STXBP5L	chr3	120941850	+	0.002785511	0.9972145
ENST00000574538	ENST00000492541	METTL4	chr18	2544194	-	STXBP5L	chr3	120941850	+	0.002594513	0.99740547

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Fusion Genomic Features for METTL4-STXBP5L

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for METTL4-STXBP5L

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:2544194/chr3:120941850)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

STXBP5L

chr18:2544194

chr3:120941850

ENST00000273666

1121_1181

318

1187.0

Domain

v-SNARE coiled-coil homology

Tgene

STXBP5L

chr18:2544194

chr3:120941850

ENST00000273666

1032_1055

318

1187.0

Repeat

Note=WD 14

Tgene

STXBP5L

chr18:2544194

chr3:120941850

ENST00000273666

357_391

318

1187.0

Repeat

Note=WD 7

Tgene

STXBP5L

chr18:2544194

chr3:120941850

ENST00000273666

413_490

318

1187.0

Repeat

Note=WD 8

Tgene

STXBP5L

chr18:2544194

chr3:120941850

ENST00000273666

518_629

318

1187.0

Repeat

Note=WD 9

Tgene

STXBP5L

chr18:2544194

chr3:120941850

ENST00000273666

643_705

318

1187.0

Repeat

Note=WD 10

Tgene

STXBP5L

chr18:2544194

chr3:120941850

ENST00000273666

832_889

318

1187.0

Repeat

Note=WD 11

Tgene

STXBP5L

chr18:2544194

chr3:120941850

ENST00000273666

898_969

318

1187.0

Repeat

Note=WD 12

Tgene

STXBP5L

chr18:2544194

chr3:120941850

ENST00000273666

974_1018

318

1187.0

Repeat

Note=WD 13

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

STXBP5L

chr18:2544194

chr3:120941850

ENST00000273666

114_153

318

1187.0

Repeat

Note=WD 2

Tgene

STXBP5L

chr18:2544194

chr3:120941850

ENST00000273666

158_194

318

1187.0

Repeat

Note=WD 3

Tgene

STXBP5L

chr18:2544194

chr3:120941850

ENST00000273666

213_247

318

1187.0

Repeat

Note=WD 4

Tgene

STXBP5L

chr18:2544194

chr3:120941850

ENST00000273666

253_285

318

1187.0

Repeat

Note=WD 5

Tgene

STXBP5L

chr18:2544194

chr3:120941850

ENST00000273666

307_349

318

1187.0

Repeat

Note=WD 6

Tgene

STXBP5L

chr18:2544194

chr3:120941850

ENST00000273666

74_107

318

1187.0

Repeat

Note=WD 1

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Fusion Gene Sequence for METTL4-STXBP5L

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>53133_53133_1_METTL4-STXBP5L_METTL4_chr18_2544194_ENST00000574538_STXBP5L_chr3_120941850_ENST00000273666_length(transcript)=10318nt_BP=2049nt
CTGGAAGGCTGCGTGCTGGTCGCGCCCAGCTGCGTCACCCCAGGAACTGGGGTCTGTGGGCCAGTGTGGCCGTCTCTACGAAGACTGGCA
CGACCCCTAAAGTTAGGTCGGAAGACCTGTGGGCAGCTTGAGCGCCGAGGAGTGCCCTGAACGCTCAACTCGCCCTGGAAACGTTTTTCC
GTACAGCAACATGGCGGCGCCCATGGACTCTTAGAAAAGGAGAAAGCTTTTTCTCTGTGGACTGGAAGGGGCATTTTTCATGATCACTAT
TTAGATGGGTGCTGTTTTCATGAGGAGAGTCTGGGAAGGCGGCGTCCGCTTTTCTGACAAGGGAAGAGGCTACTTTGTCCTTTTAAGGAT
TCAATGACTTCCTGACTTGGAGGATGTGGACCTAGTGGCTAGACCCAAGGACCAAAGCAAGAAGTCGTGGGGGGCCCAGGAAGACAGGAG
GATCACATTGGGATTCCAGACATAAGATCAGGTTTTAACCCCCTTTGGCCAAATTTTGGCTGAAAATGTTGAATTATCAACTCTGAAATT
AAAAAGAAAGTTTATATTAAAACATTGCAATTTTCCTTAGAATTTCTGTATATATTAACATCATGAATGATAAATTCTCTTCAATGTGCA
TGTCAGGTTTTTGTACTTGTATATCAAATCTATCTGTGTGTATGAAGTGTATGTTTATTGAAATACAAGATATTTAAGAAGCTGATCTGG
AAAGTTGGATTTTCATTCTAGTTCCTAATTCCCAGAGGCTTTTTTAAAGGAAGGGAATGTCTGTGGTACACCAGTTGTCAGCTGGGTGGT
TACTGGATCATCTTTCTTTTATCAACAAGATAAACTATCAACTTCACCAGCATCATGAACCTTGTTGCCGTAAAAAGGAGTTCACTACTT
CTGTTCACTTTGAGTCTCTTCAAATGGATTCTGTGTCCTCCTCTGGAGTCTGTGCTGCATTTATTGCTTCTGACTCTTCCACTAAGCCAG
AGAATGATGATGGAGGAAATTATGAAATGTTCACACGAAAATTTGTTTTTCGACCTGAACTGTTTGATGTCACCAAACCTTATATAACTC
CAGCTGTTCATAAAGAATGCCAGCAAAGTAATGAAAAGGAAGATCTGATGAATGGTGTTAAAAAAGAAATCTCCATTTCTATTATTGGGA
AGAAGCGTAAAAGATGTGTTGTTTTCAATCAAGGTGAATTGGATGCTATGGAATACCATACAAAGATCAGGGAGCTGATTTTGGATGGAT
CTTTACAGTTGATCCAGGAAGGTCTCAAAAGTGGTTTTCTTTATCCACTTTTTGAAAAACAGGACAAGGGTAGTAAGCCCATTACTTTAC
CACTTGACGCCTGCAGTTTGTCAGAATTATGTGAAATGGCAAAGCATTTGCCTTCTCTGAATGAAATGGAACATCAGACATTACAATTGG
TGGAAGAGGATACATCTGTTACAGAACAGGATTTATTTTTGCGAGTTGTTGAAAACAACTCTAGCTTTACAAAAGTGATTACTTTAATGG
GACAGAAATACCTGCTACCACCGAAAAGCAGTTTTCTTTTATCTGACATTTCTTGTATGCAACCACTTCTAAACTATAGGAAAACATTTG
ATGTAATTGTGATAGATCCACCATGGCAGAACAAATCAGTTAAAAGAAGTAATAGGTACAGTTATTTGTCACCCCTGCAAATACAGCAAA
TACCTATCCCTAAATTGGCTGCTCCAAACTGTCTTCTTGTTACTTGGGTGACCAATAGACAGAAGCACCTACGTTTTATAAAGGAAGAAC
TTTATCCCTCTTGGTCTGTGGAGGTAGTTGCTGAGTGGCACTGGGTAAAAATAACCAATTCAGGAGAATTTGTGTTCCCATTAGATTCTC
CACACAAAAAGCCCTACGAAGGTCTTATACTGGGGAGGGTTCAAGAAAAAACTGCTCTACCATTGAGGAATGCAGATGTAAACGTGCTCC
CCATTCCAGACCACAAATTAATTGTCAGCGTGCCCTGTACTCTTCACTCACATAAGCCACCGCTTGCTGCGAACCATTCATAATATTCTC
TGGTGGGCTGTCCTATGACAAAGCTTGTAGAAGACCAAGTTTAACCATCATGCATGGAAAAGCAATTACAGTACTTGAAATGGATCATCC
TATTGTTGAATTTCTAACTTTATGTGAAACGCCCTATCCAAATGAATTTCAAGAACCCTATGCTGTCGTGGTACTTCTGGAGAAAGATCT
CATTGTAGTTGATCTGACACAAAGCAATTTTCCAATCTTTGAAAATCCATATCCCATGGACATTCATGAATCACCAGTTACATGCACAGC
ATACTTTGCAGATTGTCCTCCGGATTTGATTCTAGTACTGTATTCTATAGGAGTCAAGCATAAAAAACAAGGATACAGTAATAAGGAGTG
GCCAATCAGTGGAGGAGCTTGGAACCTTGGAGCACAAACATATCCAGAAATTATTATTACTGGTCATGCAGATGGATCAATAAAATTTTG
GGATGCTTCTGCAATAACTCTGCAGATGCTGTACAAGCTAAAAACTTCAAAAGTGTTTGAAAAACAGAAGGTAGGAGAAGGAAAACAAAC
ATGTGAAATTGTAGAGGAAGACCCATTTGCCATTCAGATGATTTACTGGTGTCCAGAGAGCAGAATATTCTGTGTATCAGGAGTCTCTGC
ATATGTCATAATTTATAAATTCAGCAGACATGAAATTACAACAGAAATAGTGTCATTAGAGGTACGACTTCAGTATGATGTTGAAGATAT
TATTACCCCTGAACCAGAAACAAGTCCTCCGTTTCCAGATCTCTCAGCCCAGCTTCCTTCTTCAAGGAGTCTTTCTGGGAGCACTAACAC
TGTTGCTAGTGAAGGAGTAACAAAGGACAGTATTCCATGCCTCAATGTGAAGACACGGCCAGTGCGAATGCCTCCAGGATATCAAGCAGA
ACTTGTTATTCAATTGGTGTGGGTAGATGGTGAACCTCCACAACAGATTACTAGTCTTGCTGTAAGCTCAGCATATGGAATAGTTGCATT
TGGGAACTGCAATGGGTTGGCTGTGGTGGATTTTATACAGAAGACAGTACTGTTAAGCATGGGGACCATTGACCTATATAGATCAAGTGA
CTTATACCAGCGACAACCACGGTCTCCTCGAAAAAACAAACAGTTCATTGCAGACAACTTTTGCATGCGTGGCCTGTCTAACTTTTATCC
TGATTTAACGAAACGGATCCGTACTTCCTATCAGAGTTTAACTGAACTGAATGACAGTCCAGTTCCCCTAGAACTTGAGCGCTGCAAGTC
TCCTACCTCAGACCATGTAAATGGACACTGCACAAGTCCAACTTCTCAGAGTTGCAGTTCTGGAAAACGTCTTTCTAGTGCCGATGTTTC
AAAAGTAAATCGCTGGGGTCCTGGAAGACCACCATTTCGAAAGGCCCAGTCAGCAGCCTGCATGGAGATTTCTTTACCAGTTACAACAGA
AGAAAACCGAGAAAATTCCTATAATCGTTCTAGAAGCTCTAGTATCTCCAGTATTGACAAAGATTCTAAAGAAGCAATTACAGCACTATA
CTTCATGGACTCCTTTGCACGGAAAAATGACTCTACCATCTCTCCTTGTCTGTTCGTTGGAACCAGTCTGGGAATGGTGTTAATCATCTC
CTTAAACCTACCATTAGCAGATGAACAAAGGTTTACAGAGCCAGTCATGGTATTGCCAAGTGGTACATTCCTCTCATTGAAAGGAGCTGT
GCTAACATTCTCCTGTATGGACCGAATGGGTGGATTAATGCAACCGCCATATGAAGTTTGGAGGGATCCAAACAACATAGATGAAAATGA
AAAATCTTGGAGAAGGAAAGTGGTAATGAACTCATCTTCTGCATCCCAAGAAATAGGAGATCATCAGTATACAATAATCTGCTCAGAAAA
ACAAGCCAAAGTCTTCTCACTGCCTTCTCAGACTTGCCTTTATGTTCATAACATCACGGAGACATCTTTTATACTGCAAGCAAATGTGGT
GGTCATGTGTAGCAGTGCCTGCTTGGCATGCTTTTGTGCTAACGGACATATCATGATAATGAGCCTACCTAGTCTTCGCCCAATGTTGGA
TGTTAATTATTTGCCACTGACAGACATGAGGATAGCACGAACATTTTGTTTTACCAATGAAGGACAGGCATTATACCTCGTCTCTCCTAC
TGAAATTCAGCGGTTAACATACAGCCAAGAAATGTGTGATAATCTACAGGACATGCTAGGAGATTTGTTTACTCCCATAGAGACACCAGA
AGCTCAAAACAGAGGCTTTCTCAAGGGACTGTTTGGTGGAAGCGGACAAACATTTGACAGAGAAGAGCTCTTTGGGGAAGCTTCGGCAGG
AAAAGCATCCCGCAGCCTTGCGCAACACATTCCTGGACCAGGTAGTATAGAAGGGATGAAAGGCGCTGCTGGAGGGGTGATGGGAGAGCT
GACCCGTGCACGGATTGCACTTGATGAAAGAGGACAGAGGCTAGGAGAGCTGGAAGAGAAAACTGCAGGCATGATGACCAGTGCAGAAGC
ATTTTCCAAACATGCACATGAGTTAATGCTGAAATACAAGGATAAGAAATGGTACCAATTCTGACTTCTAAAGAAGCTGTGACTGCTTTG
AGAAACCATATTCAGGGAAACCAAATTTATTCCCAGCATCACTACTCAACTGCTAGAAGCCAGTTTCTTCTACAAAATGTTCCATTTACA
GTCAATCTGAAATTTTCATAAAAGAGATGTATCAGAGACACTGTGCAACCCAAAGGCTGGAGCCCTGGTTAAAATCCCAAAATACGGCTG
AATTTGCCTTTTCCCATGTGGAATGGAGCTATCATCTTGGCATGTCATTCGATAAGGATTTATATTTAGTAACTACGGGGAGTCCTCTTG
ATTTGAAAATTCCTGTACAAACAAAAGCATTAATGCACTTAATGAAAAAAAATCTTTGCATGATAAATTAACATCTTAAGGGGAAAAGAA
AAAAAAGCATGTTGTGATAGAAGAAAAAAAGATTCATGGTAAACTATTTCTATCAATTGGGCCACACTCAACAATTTAAAAAATCTGCAT
TTGAAGATGTCAGTGCATTTCAAATATATTTGCCATACCCAACTGAAACGGAAAACAAAACAAAACAAGAACCCAGAGTTTTCTCCTCAT
CTGTAACTTTCATTGTACTAGAACCTTATTGAATTCTTATGGCAAGAGTCTGATTAATGTTCTCTCTCCATGTTTTACATCATTCACAGT
TGTGTCAAAATCAAATATTGCCAGTATAGTAAATTATTCCCAACACAATCAGTTTCATTTCTATCACCTTCAGAATGGGTTGCTGTTTTT
AGCACAAACCATGCAGGGTTGGGTCACCTCAAAGCATTTTCTTCAGCCTGGCTTGTACTCTATAGGGGAGTTGGTAGTAGGTGTGGGGAA
TCTATAGGAACAATAGAGTTAGCTATGAGAACTGACTTCACAAAAAGGGAAATTTCACACACCCCAATTTCAGCTTCTAAAGTGATATAT
TTTAAAAGCTTCATTTGTATCCTTGTCTGCCAGTTACACAGTATATTACTGTTCAAACCCAGTAGGGTCTGCAATCGAAAGGTGCTCTTG
CAGCCTGACATTCACAAACCAAACTGGTCATTCTCTTTAGTGTGATTCAGTAAAATCTCAGTTAATGTTTTGGGAAAGGGATTCTGATTT
ATGACATTTCTGATTTACAAGGGCTTTCCTTAGAAAATACCTTTCGGTTTGATACTTACCACTGGAAATTGGTTCGATACTTACCACTGG
AAATCTTTATAAAATATAGTGATCTGTTTGCTATCTTGGTCTCAGTCATCATTATAGACAATAGAAATACATAAAGAGTTTAATGATACA
AAATCAATGCTTTTGTCCCTAGGTCAAATAATATAAGCCACTAGATTATGTCAATAGATGCCAAACACTTGTCCCTTATTAAAGACTCTT
TTAAAGCTGGAATAAAGAATATCCTTAACATGATACAAGGTATCTATAACTCACCAGAAAAGCACCAGAGTCAAAACCAAATAGAGACAC
CTACTACCATTTAACATGATTCTGGAAGTCAAAAGTTATAGGAATGTATATATACACATTCCAGGACCCATCCTGTAATATGTTGTTTCG
TCAAGAAAAGTTTTAATTATGGTTTTGGCTTATTGAATTTTTGTTTATCAAGGTCTCATTGGATTTACATTTGTGTTTCTTAAGACTTCA
CAATTTTCCTGGATTTCAGGTTATTTTATTAGCCAAAAAATCGTATTTTTATTTCCTTTTTAGTCTAATTTTTTGCTAGAAGTTGTACTT
TCTAGCAAATGTTTCTAGTGGTACAATGTTCTCAGTAATTTTGAGGAGAACAAAGATGAGTGAAAGAGTTAGATAATGTACACTAGGATA
GCATTTCTCAGAGTCCTTGAATCCTCTTGTTAAGAAAGCCTCTCTGAATCTCCCAGACTCCTGTGAACAGCCTTACGGTAACAGAATCTG
GCTTGGAAACACAGACATTACATGACTGTATAATTTATAGAATTATAAAATTATATGGTAAAAATATTAAAGAAACTTAAGAGTAGGATC
TAGAAAATACTAGTGGCCAAATTGCAATGTATTCTTTGTACCATCTGTTTCAAAGACTTAGTTTTCTGATTTTCAGAACAAATACTTTAT
CGTTTCTGTATTTTAAAAAAAACTAAAAGAGTAAAATATTAGTTTATTTTAGAAATAATGAAATTCAGTCCAAAGTAGCAGTACATTTGA
TGAGTATTTCTGAAGCCTTCAATAAGATTTAACTTGTTTTAACTTGATCTACATCGAGATTTCTCAAAAGCAGCACTATTAGCTGAAAGT
CTTTGTTGTGGGGAACTGTCCTGTGTATTGTAGGATGTTAGCAACATCCCTGGCCTCTGTCTACTAGATGCCAGTAAGAACCTCCTAGTA
ATGACAATCAAAATGTCTCCAGTCATTGCCAAAATTTCTCCCAGTTCACAGCCACTATTCTACATCATACAAAGAGGTAGATTGTGTGAA
TATGTAATATATGTTGTTGTATAAAACTGTACAATAAGTATACAATGTCTTAGCAAGATAAATTATTATACCCAAAATTACATGTGTGGT
TCATATGCAATAAGATACAATTTTGAAGAAAGCTTATAGGAATCAGTGAAAAATAACAACTACAGAATATTTTAAGGCACACAGAGAAAA
TATCAAAAAGGACATTATAGCATTTCACTGTAGAAGTGCTTAAAACCTTGGCCTCAGTGAATAGATCAAAAGTTTATAATTAGCACACCA
ATTGGAAGTAAACAGGTGCTTCTCAAATGCTTGAAAAGAAAAGGCTCTTTGAAGTAGTTAAAACGTGTCTTTCAAAATTGCTTTTATAAG
CCCTTCCTTAACGTAAGGGTAACTTCATCTCACAAACTCCTGGTTAGTGGAATCCAAATTAATGAGGTTTTACTGTATCAAAATTATTTT
TATAATTCAAAGAGATGATAGCAATAAGAAGAATCTAATGTGGATGTGATTTTTCTCTTTGAACAATTCTGTTCTGTTGCACTGACCTTA
GCACGCACGCACACACACACACACCATCGCCACCACTACCATCATCATCTTATCCTCATCTTTGGAAAATAAGTACTGTTGATCCATGTA
ATCCTTTGCATAGTCTCATCTTTACTATCTTTCTTCTATTTCGGAACATAAGAAAAATACTCCTAATAACTTGGACAATGATACAGAAAG
TGACTCTGAGCCTTAGTTACCATCAAAATTACATTCTATCTGCTAAAGCGACATCAGAAGATAAGGCTTGCAAACCACAGTCCCAACAAG
TTGACCTTGTCTCCCTATGATTTCCTTGGAAGATAAGGCCTTTTTAGTGTTACAGTAGAAAATGGGCCTTTTCATTTATTCATCTGTGAG
AAGCTAGAGGTATTTGTTTCCCTGATAATAACGTGAGCAATAGTCCCTACCTTGAAATCATCCATTAGTCTTGGAGTTTGGAGGGAGGAA
TGATTGATTCCTCATTTGTTTTAATCACCTACAAAAGCAGTACTACTGACTTTGCTTCTTACACTTCACTGAGCCCCAGACTTTAGGGCC
CCAATCATTGTCAAGATCATTGTCTAACTGGAACTCTGAAAGGACAGTGACAGAACTGAATGAGATGTTTTCCAGTGATTCAGTCACAAA
GACAATTTTCTCAGATCTTTTGAAAGTGATTCTCAAATAAATAAATCAAAATCCAACTCCTTTCCCTCAAAGTTTCTAGGGATCTGAAGG
AAAAGGTTTACTGTTGGAGTCCCTTTTTATGTGACCCATGTACCAGTTTTAAAGGCATCATCTATACTTTATCTACATGAAGGGATCACC
ATGACTTTGAGAGAAAAAAGAATCAGATTAGGCCTAACATTGGTTGAAGAAGATTAAAATAGATTCTTATATTCAAGCAGAAGGGAAAAA
TGAAGCCAATCTAGAAAAGTAAGCTAAAAATCCTCTCCTTGGCTTAGGATCATTGGGTCAAACTGGGAGTATATCTGTGTGATTACAACC
TGCTGCTATGAGAAAAAAGAATTGTAACTTGACCATGTTGGCTCACACAGGGCAATGCAAAAGAAGTCAAAACATTCATATCAGGTCTTG
GTATCTGTGTCAGGAGAAACGTGGTGGCTTTCACAGCTTCTTCACCTCTGTCCTCTGTCATGCAACTCCATTTTTGGCTAGGTACTATTT
CACATGCACACTGTCCTGGGTGCCAGAAATACTTGTGGTGTACTTGGTTTGAGCAGTACCTCTAGTATGCACCATTCCAGGGAACATGGT
TGTCAACATAACAAGTTTAGTGTGTGTATTTGCAGACAACATAGCCCTGAAAGCATGAAATGTAGAATAGGTAAGGTCTGTCTTAGAAAA
GGAGGAGGAAGTACCAATTTGGTGCAAGAAGATCGTGGTGAGGAAGGACATGGGAGCCACAGTGAAGTGAAAGAGGCTTTAAGGAATCAG
ATGCACAGATGGATGCTTTGATTTACACATTTATCTAGAGGAGTGATTCTCAACCTTGACTGTACATAAGAATCACCTCAGGAAATTTTT
AAATTCCCAATTATATTAAAATCATTTGGAGTGGGAACCAGACACCAATATTTGCGAAAGCCTCCAAGGCGGTTCTAATGTCCAGCCAAA
GTTGATTATCACTGCTTTATGGCCAACTAAGGAAACCTTGTTTGTCTGCCTTGGCTGGTGCTCCAGCCCCAGTTCTGAGTGGTCAGGGAA
GGCAAGATGTAAGATATAGTAATGGTATTTATTCTGTATGTCTCACAGAACAAAAGCATTTGAGAATTTCTGACCAGGCAGTGCTCCATC
AACTCTTAATAATCATCTTTGTGATATTCTCCTATGTGACTTGTCCATCAATTATTCCAATTCAAAGGTCTAGGTTTTTTTTCAATTGTC
TTACACATGTGACATCACAAGATACCAGAAGTAGCACAGTAAATTCAAGAGCATATAAAGCTAAGTGGAAAACTAATTCTTCATATTTAG
ACAGTGGAAATTCTCAAAACAATCATTTGCTAAATTAGGTCCAAATTTATTATTCATTCTTCTTCTGGAGGAGACATGGGTACCAGGTAC
CTGTTCTGCTGTAGGTATATTTCACTGGACTTGGTCTTAGCAAAAAGGAAGAACAAATCTTCCTTTTTGATTGTTATCTCAATCAAAAGC
TCCCAGGGCCACTTGGATTTATTTTCTTAGTCTTTGGACATGTGTTTAAAGGAAAAGAATACCTGTAACTTCCTATATGACATCCAGTGC
CCTGAAAGGGTGCTTACACCTTCAAAAAAGGAGAGTCCAGCCTATCAAAGGCAGTAACACATAATGAGAAGAAACTCAGAGTTATTGCCT
TTCATACTGCTTTCCCTCTGCTGTTGGCCCACCCTTCTTGACTGCAAAGCCAGAAAATAAACTAGATGGTGGTTTTGGACAATTGTACAC
AGGAACAGAATCTCTAATAACCTATAATTTTTAGTACTTAATTATGTGATGTTTTATTCTAGGAAATAAGAAACAGATGACATCATTGAT
GTATCTTTCTTTCATCTTCAGAATTTTTGCATCTTTTCAGAAAATGACAAATTACTATTTTTCTGTTGCACTCAGCAATTGTGACTATAC

>53133_53133_1_METTL4-STXBP5L_METTL4_chr18_2544194_ENST00000574538_STXBP5L_chr3_120941850_ENST00000273666_length(amino acids)=858AA_BP=
MSYDKACRRPSLTIMHGKAITVLEMDHPIVEFLTLCETPYPNEFQEPYAVVVLLEKDLIVVDLTQSNFPIFENPYPMDIHESPVTCTAYF
ADCPPDLILVLYSIGVKHKKQGYSNKEWPISGGAWNLGAQTYPEIIITGHADGSIKFWDASAITLQMLYKLKTSKVFEKQKVGEGKQTCE
IVEEDPFAIQMIYWCPESRIFCVSGVSAYVIIYKFSRHEITTEIVSLEVRLQYDVEDIITPEPETSPPFPDLSAQLPSSRSLSGSTNTVA
SEGVTKDSIPCLNVKTRPVRMPPGYQAELVIQLVWVDGEPPQQITSLAVSSAYGIVAFGNCNGLAVVDFIQKTVLLSMGTIDLYRSSDLY
QRQPRSPRKNKQFIADNFCMRGLSNFYPDLTKRIRTSYQSLTELNDSPVPLELERCKSPTSDHVNGHCTSPTSQSCSSGKRLSSADVSKV
NRWGPGRPPFRKAQSAACMEISLPVTTEENRENSYNRSRSSSISSIDKDSKEAITALYFMDSFARKNDSTISPCLFVGTSLGMVLIISLN
LPLADEQRFTEPVMVLPSGTFLSLKGAVLTFSCMDRMGGLMQPPYEVWRDPNNIDENEKSWRRKVVMNSSSASQEIGDHQYTIICSEKQA
KVFSLPSQTCLYVHNITETSFILQANVVVMCSSACLACFCANGHIMIMSLPSLRPMLDVNYLPLTDMRIARTFCFTNEGQALYLVSPTEI
QRLTYSQEMCDNLQDMLGDLFTPIETPEAQNRGFLKGLFGGSGQTFDREELFGEASAGKASRSLAQHIPGPGSIEGMKGAAGGVMGELTR

--------------------------------------------------------------
>53133_53133_2_METTL4-STXBP5L_METTL4_chr18_2544194_ENST00000574538_STXBP5L_chr3_120941850_ENST00000471454_length(transcript)=4768nt_BP=2049nt
CTGGAAGGCTGCGTGCTGGTCGCGCCCAGCTGCGTCACCCCAGGAACTGGGGTCTGTGGGCCAGTGTGGCCGTCTCTACGAAGACTGGCA
CGACCCCTAAAGTTAGGTCGGAAGACCTGTGGGCAGCTTGAGCGCCGAGGAGTGCCCTGAACGCTCAACTCGCCCTGGAAACGTTTTTCC
GTACAGCAACATGGCGGCGCCCATGGACTCTTAGAAAAGGAGAAAGCTTTTTCTCTGTGGACTGGAAGGGGCATTTTTCATGATCACTAT
TTAGATGGGTGCTGTTTTCATGAGGAGAGTCTGGGAAGGCGGCGTCCGCTTTTCTGACAAGGGAAGAGGCTACTTTGTCCTTTTAAGGAT
TCAATGACTTCCTGACTTGGAGGATGTGGACCTAGTGGCTAGACCCAAGGACCAAAGCAAGAAGTCGTGGGGGGCCCAGGAAGACAGGAG
GATCACATTGGGATTCCAGACATAAGATCAGGTTTTAACCCCCTTTGGCCAAATTTTGGCTGAAAATGTTGAATTATCAACTCTGAAATT
AAAAAGAAAGTTTATATTAAAACATTGCAATTTTCCTTAGAATTTCTGTATATATTAACATCATGAATGATAAATTCTCTTCAATGTGCA
TGTCAGGTTTTTGTACTTGTATATCAAATCTATCTGTGTGTATGAAGTGTATGTTTATTGAAATACAAGATATTTAAGAAGCTGATCTGG
AAAGTTGGATTTTCATTCTAGTTCCTAATTCCCAGAGGCTTTTTTAAAGGAAGGGAATGTCTGTGGTACACCAGTTGTCAGCTGGGTGGT
TACTGGATCATCTTTCTTTTATCAACAAGATAAACTATCAACTTCACCAGCATCATGAACCTTGTTGCCGTAAAAAGGAGTTCACTACTT
CTGTTCACTTTGAGTCTCTTCAAATGGATTCTGTGTCCTCCTCTGGAGTCTGTGCTGCATTTATTGCTTCTGACTCTTCCACTAAGCCAG
AGAATGATGATGGAGGAAATTATGAAATGTTCACACGAAAATTTGTTTTTCGACCTGAACTGTTTGATGTCACCAAACCTTATATAACTC
CAGCTGTTCATAAAGAATGCCAGCAAAGTAATGAAAAGGAAGATCTGATGAATGGTGTTAAAAAAGAAATCTCCATTTCTATTATTGGGA
AGAAGCGTAAAAGATGTGTTGTTTTCAATCAAGGTGAATTGGATGCTATGGAATACCATACAAAGATCAGGGAGCTGATTTTGGATGGAT
CTTTACAGTTGATCCAGGAAGGTCTCAAAAGTGGTTTTCTTTATCCACTTTTTGAAAAACAGGACAAGGGTAGTAAGCCCATTACTTTAC
CACTTGACGCCTGCAGTTTGTCAGAATTATGTGAAATGGCAAAGCATTTGCCTTCTCTGAATGAAATGGAACATCAGACATTACAATTGG
TGGAAGAGGATACATCTGTTACAGAACAGGATTTATTTTTGCGAGTTGTTGAAAACAACTCTAGCTTTACAAAAGTGATTACTTTAATGG
GACAGAAATACCTGCTACCACCGAAAAGCAGTTTTCTTTTATCTGACATTTCTTGTATGCAACCACTTCTAAACTATAGGAAAACATTTG
ATGTAATTGTGATAGATCCACCATGGCAGAACAAATCAGTTAAAAGAAGTAATAGGTACAGTTATTTGTCACCCCTGCAAATACAGCAAA
TACCTATCCCTAAATTGGCTGCTCCAAACTGTCTTCTTGTTACTTGGGTGACCAATAGACAGAAGCACCTACGTTTTATAAAGGAAGAAC
TTTATCCCTCTTGGTCTGTGGAGGTAGTTGCTGAGTGGCACTGGGTAAAAATAACCAATTCAGGAGAATTTGTGTTCCCATTAGATTCTC
CACACAAAAAGCCCTACGAAGGTCTTATACTGGGGAGGGTTCAAGAAAAAACTGCTCTACCATTGAGGAATGCAGATGTAAACGTGCTCC
CCATTCCAGACCACAAATTAATTGTCAGCGTGCCCTGTACTCTTCACTCACATAAGCCACCGCTTGCTGCGAACCATTCATAATATTCTC
TGGTGGGCTGTCCTATGACAAAGCTTGTAGAAGACCAAGTTTAACCATCATGCATGGAAAAGCAATTACAGTACTTGAAATGGATCATCC
TATTGTTGAATTTCTAACTTTATGTGAAACGCCCTATCCAAATGAATTTCAAGAACCCTATGCTGTCGTGGTACTTCTGGAGAAAGATCT
CATTGTAGTTGATCTGACACAAAGCAATTTTCCAATCTTTGAAAATCCATATCCCATGGACATTCATGAATCACCAGTTACATGCACAGC
ATACTTTGCAGATTGTCCTCCGGATTTGATTCTAGTACTGTATTCTATAGGAGTCAAGCATAAAAAACAAGGATACAGTAATAAGGAGTG
GCCAATCAGTGGAGGAGCTTGGAACCTTGGAGCACAAACATATCCAGAAATTATTATTACTGGTCATGCAGATGGATCAATAAAATTTTG
GGATGCTTCTGCAATAACTCTGCAGATGCTGTACAAGCTAAAAACTTCAAAAGTGTTTGAAAAACAGAAGGTAGGAGAAGGAAAACAAAC
ATGTGAAATTGTAGAGGAAGACCCATTTGCCATTCAGATGATTTACTGGTGTCCAGAGAGCAGAATATTCTGTGTATCAGGAGTCTCTGC
ATATGTCATAATTTATAAATTCAGCAGACATGAAATTACAACAGAAATAGTGTCATTAGAGGTACGACTTCAGTATGATGTTGAAGATAT
TATTACCCCTGAACCAGAAACAAGTCCTCCGTTTCCAGATCTCTCAGCCCAGCTTCCTTCTTCAAGGAGTCTTTCTGGGAGCACTAACAC
TGTTGCTAGTGAAGGAGTAACAAAGGACAGTATTCCATGCCTCAATGTGAAGACACGGCCAGTGCGAATGCCTCCAGGATATCAAGCAGA
ACTTGTTATTCAATTGGTGTGGGTAGATGGTGAACCTCCACAACAGATTACTAGTCTTGCTGTAAGCTCAGCATATGGAATAGTTGCATT
TGGGAACTGCAATGGGTTGGCTGTGGTGGATTTTATACAGAAGACAGTACTGTTAAGCATGGGGACCATTGACCTATATAGATCAAGTGA
CTTATACCAGCGACAACCACGGTCTCCTCGAAAAAACAAACAGTTCATTGCAGGTTTAACTGAACTGAATGACAGTCCAGTTCCCCTAGA
ACTTGAGCGCTGCAAGTCTCCTACCTCAGACCATGTAAATGGACACTGCACAAGTCCAACTTCTCAGAGTTGCAGTTCTGGAAAACGTCT
TTCTAGTGCCGATGTTTCAAAAGTAAATCGCTGGGGTCCTGGAAGACCACCATTTCGAAAGGCCCAGTCAGCAGCCTGCATGGAGATTTC
TTTACCAGTTACAACAGAAGAAAACCGAGAAAATTCCTATAATCGTTCTAGAAGCTCTAGTATCTCCAGTATTGACAAAGATTCTAAAGA
AGCAATTACAGCACTATACTTCATGGACTCCTTTGCACGGAAAAATGACTCTACCATCTCTCCTTGTCTGTTCGTTGGAACCAGTCTGGG
AATGGTGTTAATCATCTCCTTAAACCTACCATTAGCAGATGAACAAAGGTTTACAGAGCCAGTCATGGTATTGCCAAGTGGTACATTCCT
CTCATTGAAAGGAGCTGTGCTAACATTCTCCTGTATGGACCGAATGGGTGGATTAATGCAACCGCCATATGAAGTTTGGAGGGATCCAAA
CAACATAGATGAAAATGAAAAATCTTGGAGAAGGAAAGTGGTAATGAACTCATCTTCTGCATCCCAAGAAATAGGAGATCATCAGTATAC
AATAATCTGCTCAGAAAAACAAGCCAAAGTCTTCTCACTGCCTTCTCAGACTTGCCTTTATGTTCATAACATCACGGAGACATCTTTTAT
ACTGCAAGCAAATGTGGTGGTCATGTGTAGCAGTGCCTGCTTGGCATGCTTTTGTGCTAACGGACATATCATGATAATGAGCCTACCTAG
TCTTCGCCCAATGTTGGATGTTAATTATTTGCCACTGACAGACATGAGGATAGCACGAACATTTTGTTTTACCAATGAAGGACAGGCATT
ATACCTCGTCTCTCCTACTGAAATTCAGCGGTTAACATACAGCCAAGAAATGTGTGATAATCTACAGGACATGCTAGGAGATTTGTTTAC
TCCCATAGAGACACCAGAAGCTCAAAACAGAGGCTTTCTCAAGGGACTGTTTGGTGGAAGCGGACAAACATTTGACAGAGAAGAGCTCTT
TGGGGAAGCTTCGGCAGGAAAAGCATCCCGCAGCCTTGCGCAACACATTCCTGGACCAGGTAGTATAGAAGGGATGAAAGGCGCTGCTGG
AGGGGTGATGGGAGAGCTGACCCGTGCACGGATTGCACTTGATGAAAGAGGACAGAGGCTAGGAGAGCTGGAAGAGAAAACTGCAGGCAT
GATGACCAGTGCAGAAGCATTTTCCAAACATGCACATGAGTTAATGCTGAAATACAAGGATAAGAAATGGTACCAATTCTGACTTCTAAA
GAAGCTGTGACTGCTTTGAGAAACCATATTCAGGGAAACCAAATTTATTCCCAGCATCACTACTCAACTGCTAGAAGCCAGTTTCTTCTA

>53133_53133_2_METTL4-STXBP5L_METTL4_chr18_2544194_ENST00000574538_STXBP5L_chr3_120941850_ENST00000471454_length(amino acids)=834AA_BP=
MSYDKACRRPSLTIMHGKAITVLEMDHPIVEFLTLCETPYPNEFQEPYAVVVLLEKDLIVVDLTQSNFPIFENPYPMDIHESPVTCTAYF
ADCPPDLILVLYSIGVKHKKQGYSNKEWPISGGAWNLGAQTYPEIIITGHADGSIKFWDASAITLQMLYKLKTSKVFEKQKVGEGKQTCE
IVEEDPFAIQMIYWCPESRIFCVSGVSAYVIIYKFSRHEITTEIVSLEVRLQYDVEDIITPEPETSPPFPDLSAQLPSSRSLSGSTNTVA
SEGVTKDSIPCLNVKTRPVRMPPGYQAELVIQLVWVDGEPPQQITSLAVSSAYGIVAFGNCNGLAVVDFIQKTVLLSMGTIDLYRSSDLY
QRQPRSPRKNKQFIAGLTELNDSPVPLELERCKSPTSDHVNGHCTSPTSQSCSSGKRLSSADVSKVNRWGPGRPPFRKAQSAACMEISLP
VTTEENRENSYNRSRSSSISSIDKDSKEAITALYFMDSFARKNDSTISPCLFVGTSLGMVLIISLNLPLADEQRFTEPVMVLPSGTFLSL
KGAVLTFSCMDRMGGLMQPPYEVWRDPNNIDENEKSWRRKVVMNSSSASQEIGDHQYTIICSEKQAKVFSLPSQTCLYVHNITETSFILQ
ANVVVMCSSACLACFCANGHIMIMSLPSLRPMLDVNYLPLTDMRIARTFCFTNEGQALYLVSPTEIQRLTYSQEMCDNLQDMLGDLFTPI
ETPEAQNRGFLKGLFGGSGQTFDREELFGEASAGKASRSLAQHIPGPGSIEGMKGAAGGVMGELTRARIALDERGQRLGELEEKTAGMMT

--------------------------------------------------------------
>53133_53133_3_METTL4-STXBP5L_METTL4_chr18_2544194_ENST00000574538_STXBP5L_chr3_120941850_ENST00000472879_length(transcript)=4106nt_BP=2049nt
CTGGAAGGCTGCGTGCTGGTCGCGCCCAGCTGCGTCACCCCAGGAACTGGGGTCTGTGGGCCAGTGTGGCCGTCTCTACGAAGACTGGCA
CGACCCCTAAAGTTAGGTCGGAAGACCTGTGGGCAGCTTGAGCGCCGAGGAGTGCCCTGAACGCTCAACTCGCCCTGGAAACGTTTTTCC
GTACAGCAACATGGCGGCGCCCATGGACTCTTAGAAAAGGAGAAAGCTTTTTCTCTGTGGACTGGAAGGGGCATTTTTCATGATCACTAT
TTAGATGGGTGCTGTTTTCATGAGGAGAGTCTGGGAAGGCGGCGTCCGCTTTTCTGACAAGGGAAGAGGCTACTTTGTCCTTTTAAGGAT
TCAATGACTTCCTGACTTGGAGGATGTGGACCTAGTGGCTAGACCCAAGGACCAAAGCAAGAAGTCGTGGGGGGCCCAGGAAGACAGGAG
GATCACATTGGGATTCCAGACATAAGATCAGGTTTTAACCCCCTTTGGCCAAATTTTGGCTGAAAATGTTGAATTATCAACTCTGAAATT
AAAAAGAAAGTTTATATTAAAACATTGCAATTTTCCTTAGAATTTCTGTATATATTAACATCATGAATGATAAATTCTCTTCAATGTGCA
TGTCAGGTTTTTGTACTTGTATATCAAATCTATCTGTGTGTATGAAGTGTATGTTTATTGAAATACAAGATATTTAAGAAGCTGATCTGG
AAAGTTGGATTTTCATTCTAGTTCCTAATTCCCAGAGGCTTTTTTAAAGGAAGGGAATGTCTGTGGTACACCAGTTGTCAGCTGGGTGGT
TACTGGATCATCTTTCTTTTATCAACAAGATAAACTATCAACTTCACCAGCATCATGAACCTTGTTGCCGTAAAAAGGAGTTCACTACTT
CTGTTCACTTTGAGTCTCTTCAAATGGATTCTGTGTCCTCCTCTGGAGTCTGTGCTGCATTTATTGCTTCTGACTCTTCCACTAAGCCAG
AGAATGATGATGGAGGAAATTATGAAATGTTCACACGAAAATTTGTTTTTCGACCTGAACTGTTTGATGTCACCAAACCTTATATAACTC
CAGCTGTTCATAAAGAATGCCAGCAAAGTAATGAAAAGGAAGATCTGATGAATGGTGTTAAAAAAGAAATCTCCATTTCTATTATTGGGA
AGAAGCGTAAAAGATGTGTTGTTTTCAATCAAGGTGAATTGGATGCTATGGAATACCATACAAAGATCAGGGAGCTGATTTTGGATGGAT
CTTTACAGTTGATCCAGGAAGGTCTCAAAAGTGGTTTTCTTTATCCACTTTTTGAAAAACAGGACAAGGGTAGTAAGCCCATTACTTTAC
CACTTGACGCCTGCAGTTTGTCAGAATTATGTGAAATGGCAAAGCATTTGCCTTCTCTGAATGAAATGGAACATCAGACATTACAATTGG
TGGAAGAGGATACATCTGTTACAGAACAGGATTTATTTTTGCGAGTTGTTGAAAACAACTCTAGCTTTACAAAAGTGATTACTTTAATGG
GACAGAAATACCTGCTACCACCGAAAAGCAGTTTTCTTTTATCTGACATTTCTTGTATGCAACCACTTCTAAACTATAGGAAAACATTTG
ATGTAATTGTGATAGATCCACCATGGCAGAACAAATCAGTTAAAAGAAGTAATAGGTACAGTTATTTGTCACCCCTGCAAATACAGCAAA
TACCTATCCCTAAATTGGCTGCTCCAAACTGTCTTCTTGTTACTTGGGTGACCAATAGACAGAAGCACCTACGTTTTATAAAGGAAGAAC
TTTATCCCTCTTGGTCTGTGGAGGTAGTTGCTGAGTGGCACTGGGTAAAAATAACCAATTCAGGAGAATTTGTGTTCCCATTAGATTCTC
CACACAAAAAGCCCTACGAAGGTCTTATACTGGGGAGGGTTCAAGAAAAAACTGCTCTACCATTGAGGAATGCAGATGTAAACGTGCTCC
CCATTCCAGACCACAAATTAATTGTCAGCGTGCCCTGTACTCTTCACTCACATAAGCCACCGCTTGCTGCGAACCATTCATAATATTCTC
TGGTGGGCTGTCCTATGACAAAGCTTGTAGAAGACCAAGTTTAACCATCATGCATGGAAAAGCAATTACAGTACTTGAAATGGATCATCC
TATTGTTGAATTTCTAACTTTATGTGAAACGCCCTATCCAAATGAATTTCAAGAACCCTATGCTGTCGTGGTACTTCTGGAGAAAGATCT
CATTGTAGTTGATCTGACACAAAGCAATTTTCCAATCTTTGAAAATCCATATCCCATGGACATTCATGAATCACCAGTTACATGCACAGC
ATACTTTGCAGATTGTCCTCCGGATTTGATTCTAGTACTGTATTCTATAGGAGTCAAGCATAAAAAACAAGGATACAGTAATAAGGAGTG
GCCAATCAGTGGAGGAGCTTGGAACCTTGGAGCACAAACATATCCAGAAATTATTATTACTGGTCATGCAGATGGATCAATAAAATTTTG
GGATGCTTCTGCAATAACTCTGCAGATGCTGTACAAGCTAAAAACTTCAAAAGTGTTTGAAAAACAGAAGGTAGGAGAAGGAAAACAAAC
ATGTGAAATTGTAGAGGAAGACCCATTTGCCATTCAGATGATTTACTGGTGTCCAGAGAGCAGAATATTCTGTGTATCAGGAGTCTCTGC
ATATGTCATAATTTATAAATTCAGCAGACATGAAATTACAACAGAAATAGTGTCATTAGAGGTACGACTTCAGTATGATGTTGAAGATAT
TATTACCCCTGAACCAGAAACAAGTCCTCCGTTTCCAGATCTCTCAGCCCAGCTTCCTTCTTCAAGGAGTCTTTCTGGGAGCACTAACAC
TGTTGCTAGTGAAGGAGTAACAAAGGACAGTATTCCATGCCTCAATGTGAAGACACGGCCAGTGCGAATGCCTCCAGGATATCAAGCAGA
ACTTGTTATTCAATTGGTGTGGGTAGATGGTGAACCTCCACAACAGATTACTAGTCTTGCTGTAAGCTCAGCATATGGAATAGTTGCATT
TGGGAACTGCAATGGGTTGGCTGTGGTGGATTTTATACAGAAGACAGTACTGTTAAGCATGGGGACCATTGACCTATATAGATCAAGTGA
CTTATACCAGCGACAACCACGGTCTCCTCGAAAAAACAAACAGTTCATTGCAGGTTTAACTGAACTGAATGACAGTCCAGTTCCCCTAGA
ACTTGAGCGCTGCAAGTCTCCTACCTCAGACCATGTAAATGGACACTGCACAAGTCCAACTTCTCAGAGTTGCAGTTCTGGAAAACGTCT
TTCTAGTGCCGATGTTTCAAAAGTAAATCGCTGGGGTCCTGGAAGACCACCATTTCGAAAGGCCCAGTCAGCAGCCTGCATGGAGATTTC
TTTACCAGTTACAACAGAAGAAAACCGAGAAAATTCCTATAATCGTTCTAGAAGCTCTAGTATCTCCAGTATTGACAAAGATTCTAAAGA
AGCAATTACAGCACTATACTTCATGGACTCCTTTGCACGGAAAAATGACTCTACCATCTCTCCTTGTCTGTTCGTTGGAACCAGTCTGGG
AATGGTGTTAATCATCTCCTTAAACCTACCATTAGCAGATGAACAAAGGTTTACAGAGCCAGTCATGGTATTGCCAAGTGGTACATTCCT
CTCATTGAAAGGAGCTGTGCTAACATTCTCCTGTATGGACCGAATGGGTGGATTAATGCAACCGCCATATGAAGTTTGGAGGGATCCAAA
CAACATAGATGAAAATGAAAAATCTTGGAGAAGGAAAGTGGTAATGAACTCATCTTCTGCATCCCAAGAAATAGGAGATCATCAGTATAC
AATAATCTGCTCAGAAAAACAAGCCAAAGTCTTCTCACTGCCTTCTCAGACTTGCCTTTATGTTCATAACATCACGGAGACATCTTTTAT
ACTGCAAGCAAATGTGGTGGTCATGTGTAGCAGTGCCTGCTTGGCATGCTTTTGTGCTAACGGACATATCATGATAATGAGGTACTTGCC

>53133_53133_3_METTL4-STXBP5L_METTL4_chr18_2544194_ENST00000574538_STXBP5L_chr3_120941850_ENST00000472879_length(amino acids)=674AA_BP=
MSYDKACRRPSLTIMHGKAITVLEMDHPIVEFLTLCETPYPNEFQEPYAVVVLLEKDLIVVDLTQSNFPIFENPYPMDIHESPVTCTAYF
ADCPPDLILVLYSIGVKHKKQGYSNKEWPISGGAWNLGAQTYPEIIITGHADGSIKFWDASAITLQMLYKLKTSKVFEKQKVGEGKQTCE
IVEEDPFAIQMIYWCPESRIFCVSGVSAYVIIYKFSRHEITTEIVSLEVRLQYDVEDIITPEPETSPPFPDLSAQLPSSRSLSGSTNTVA
SEGVTKDSIPCLNVKTRPVRMPPGYQAELVIQLVWVDGEPPQQITSLAVSSAYGIVAFGNCNGLAVVDFIQKTVLLSMGTIDLYRSSDLY
QRQPRSPRKNKQFIAGLTELNDSPVPLELERCKSPTSDHVNGHCTSPTSQSCSSGKRLSSADVSKVNRWGPGRPPFRKAQSAACMEISLP
VTTEENRENSYNRSRSSSISSIDKDSKEAITALYFMDSFARKNDSTISPCLFVGTSLGMVLIISLNLPLADEQRFTEPVMVLPSGTFLSL
KGAVLTFSCMDRMGGLMQPPYEVWRDPNNIDENEKSWRRKVVMNSSSASQEIGDHQYTIICSEKQAKVFSLPSQTCLYVHNITETSFILQ

--------------------------------------------------------------
>53133_53133_4_METTL4-STXBP5L_METTL4_chr18_2544194_ENST00000574538_STXBP5L_chr3_120941850_ENST00000492541_length(transcript)=4178nt_BP=2049nt
CTGGAAGGCTGCGTGCTGGTCGCGCCCAGCTGCGTCACCCCAGGAACTGGGGTCTGTGGGCCAGTGTGGCCGTCTCTACGAAGACTGGCA
CGACCCCTAAAGTTAGGTCGGAAGACCTGTGGGCAGCTTGAGCGCCGAGGAGTGCCCTGAACGCTCAACTCGCCCTGGAAACGTTTTTCC
GTACAGCAACATGGCGGCGCCCATGGACTCTTAGAAAAGGAGAAAGCTTTTTCTCTGTGGACTGGAAGGGGCATTTTTCATGATCACTAT
TTAGATGGGTGCTGTTTTCATGAGGAGAGTCTGGGAAGGCGGCGTCCGCTTTTCTGACAAGGGAAGAGGCTACTTTGTCCTTTTAAGGAT
TCAATGACTTCCTGACTTGGAGGATGTGGACCTAGTGGCTAGACCCAAGGACCAAAGCAAGAAGTCGTGGGGGGCCCAGGAAGACAGGAG
GATCACATTGGGATTCCAGACATAAGATCAGGTTTTAACCCCCTTTGGCCAAATTTTGGCTGAAAATGTTGAATTATCAACTCTGAAATT
AAAAAGAAAGTTTATATTAAAACATTGCAATTTTCCTTAGAATTTCTGTATATATTAACATCATGAATGATAAATTCTCTTCAATGTGCA
TGTCAGGTTTTTGTACTTGTATATCAAATCTATCTGTGTGTATGAAGTGTATGTTTATTGAAATACAAGATATTTAAGAAGCTGATCTGG
AAAGTTGGATTTTCATTCTAGTTCCTAATTCCCAGAGGCTTTTTTAAAGGAAGGGAATGTCTGTGGTACACCAGTTGTCAGCTGGGTGGT
TACTGGATCATCTTTCTTTTATCAACAAGATAAACTATCAACTTCACCAGCATCATGAACCTTGTTGCCGTAAAAAGGAGTTCACTACTT
CTGTTCACTTTGAGTCTCTTCAAATGGATTCTGTGTCCTCCTCTGGAGTCTGTGCTGCATTTATTGCTTCTGACTCTTCCACTAAGCCAG
AGAATGATGATGGAGGAAATTATGAAATGTTCACACGAAAATTTGTTTTTCGACCTGAACTGTTTGATGTCACCAAACCTTATATAACTC
CAGCTGTTCATAAAGAATGCCAGCAAAGTAATGAAAAGGAAGATCTGATGAATGGTGTTAAAAAAGAAATCTCCATTTCTATTATTGGGA
AGAAGCGTAAAAGATGTGTTGTTTTCAATCAAGGTGAATTGGATGCTATGGAATACCATACAAAGATCAGGGAGCTGATTTTGGATGGAT
CTTTACAGTTGATCCAGGAAGGTCTCAAAAGTGGTTTTCTTTATCCACTTTTTGAAAAACAGGACAAGGGTAGTAAGCCCATTACTTTAC
CACTTGACGCCTGCAGTTTGTCAGAATTATGTGAAATGGCAAAGCATTTGCCTTCTCTGAATGAAATGGAACATCAGACATTACAATTGG
TGGAAGAGGATACATCTGTTACAGAACAGGATTTATTTTTGCGAGTTGTTGAAAACAACTCTAGCTTTACAAAAGTGATTACTTTAATGG
GACAGAAATACCTGCTACCACCGAAAAGCAGTTTTCTTTTATCTGACATTTCTTGTATGCAACCACTTCTAAACTATAGGAAAACATTTG
ATGTAATTGTGATAGATCCACCATGGCAGAACAAATCAGTTAAAAGAAGTAATAGGTACAGTTATTTGTCACCCCTGCAAATACAGCAAA
TACCTATCCCTAAATTGGCTGCTCCAAACTGTCTTCTTGTTACTTGGGTGACCAATAGACAGAAGCACCTACGTTTTATAAAGGAAGAAC
TTTATCCCTCTTGGTCTGTGGAGGTAGTTGCTGAGTGGCACTGGGTAAAAATAACCAATTCAGGAGAATTTGTGTTCCCATTAGATTCTC
CACACAAAAAGCCCTACGAAGGTCTTATACTGGGGAGGGTTCAAGAAAAAACTGCTCTACCATTGAGGAATGCAGATGTAAACGTGCTCC
CCATTCCAGACCACAAATTAATTGTCAGCGTGCCCTGTACTCTTCACTCACATAAGCCACCGCTTGCTGCGAACCATTCATAATATTCTC
TGGTGGGCTGTCCTATGACAAAGCTTGTAGAAGACCAAGTTTAACCATCATGCATGGAAAAGCAATTACAGTACTTGAAATGGATCATCC
TATTGTTGAATTTCTAACTTTATGTGAAACGCCCTATCCAAATGAATTTCAAGAACCCTATGCTGTCGTGGTACTTCTGGAGAAAGATCT
CATTGTAGTTGATCTGACACAAAGCAATTTTCCAATCTTTGAAAATCCATATCCCATGGACATTCATGAATCACCAGTTACATGCACAGC
ATACTTTGCAGATTGTCCTCCGGATTTGATTCTAGTACTGTATTCTATAGGAGTCAAGCATAAAAAACAAGGATACAGTAATAAGGAGTG
GCCAATCAGTGGAGGAGCTTGGAACCTTGGAGCACAAACATATCCAGAAATTATTATTACTGGTCATGCAGATGGATCAATAAAATTTTG
GGATGCTTCTGCAATAACTCTGCAGATGCTGTACAAGCTAAAAACTTCAAAAGTGTTTGAAAAACAGAAGGTAGGAGAAGGAAAACAAAC
ATGTGAAATTGTAGAGGAAGACCCATTTGCCATTCAGATGATTTACTGGTGTCCAGAGAGCAGAATATTCTGTGTATCAGGAGTCTCTGC
ATATGTCATAATTTATAAATTCAGCAGACATGAAATTACAACAGAAATAGTGTCATTAGAGGTACGACTTCAGTATGATGTTGAAGATAT
TATTACCCCTGAACCAGAAACAAGTCCTCCGTTTCCAGATCTCTCAGCCCAGCTTCCTTCTTCAAGGAGTCTTTCTGGGAGCACTAACAC
TGTTGCTAGTGAAGGAGTAACAAAGGACAGTATTCCATGCCTCAATGTGAAGACACGGCCAGTGCGAATGCCTCCAGGATATCAAGCAGA
ACTTGTTATTCAATTGGTGTGGGTAGATGGTGAACCTCCACAACAGATTACTAGTCTTGCTGTAAGCTCAGCATATGGAATAGTTGCATT
TGGGAACTGCAATGGGTTGGCTGTGGTGGATTTTATACAGAAGACAGTACTGTTAAGCATGGGGACCATTGACCTATATAGATCAAGTGA
CTTATACCAGCGACAACCACGGTCTCCTCGAAAAAACAAACAGTTCATTGCAGACAACTTTTGCATGCGTGGCCTGTCTAACTTTTATCC
TGATTTAACGAAACGGATCCGTACTTCCTATCAGAGTTTAACTGAACTGAATGACAGTCCAGTTCCCCTAGAACTTGAGCGCTGCAAGTC
TCCTACCTCAGACCATGTAAATGGACACTGCACAAGTCCAACTTCTCAGAGTTGCAGTTCTGGAAAACGTCTTTCTAGTGCCGATGTTTC
AAAAGTAAATCGCTGGGGTCCTGGAAGACCACCATTTCGAAAGGCCCAGTCAGCAGCCTGCATGGAGATTTCTTTACCAGTTACAACAGA
AGAAAACCGAGAAAATTCCTATAATCGTTCTAGAAGCTCTAGTATCTCCAGTATTGACAAAGATTCTAAAGAAGCAATTACAGCACTATA
CTTCATGGACTCCTTTGCACGGAAAAATGACTCTACCATCTCTCCTTGTCTGTTCGTTGGAACCAGTCTGGGAATGGTGTTAATCATCTC
CTTAAACCTACCATTAGCAGATGAACAAAGGTTTACAGAGCCAGTCATGGTATTGCCAAGTGGTACATTCCTCTCATTGAAAGGAGCTGT
GCTAACATTCTCCTGTATGGACCGAATGGGTGGATTAATGCAACCGCCATATGAAGTTTGGAGGGATCCAAACAACATAGATGAAAATGA
AAAATCTTGGAGAAGGAAAGTGGTAATGAACTCATCTTCTGCATCCCAAGAAATAGGAGATCATCAGTATACAATAATCTGCTCAGAAAA
ACAAGCCAAAGTCTTCTCACTGCCTTCTCAGACTTGCCTTTATGTTCATAACATCACGGAGACATCTTTTATACTGCAAGCAAATGTGGT
GGTCATGTGTAGCAGTGCCTGCTTGGCATGCTTTTGTGCTAACGGACATATCATGATAATGAGGTACTTGCCTTCTTATAAATTATCTGG

>53133_53133_4_METTL4-STXBP5L_METTL4_chr18_2544194_ENST00000574538_STXBP5L_chr3_120941850_ENST00000492541_length(amino acids)=698AA_BP=
MSYDKACRRPSLTIMHGKAITVLEMDHPIVEFLTLCETPYPNEFQEPYAVVVLLEKDLIVVDLTQSNFPIFENPYPMDIHESPVTCTAYF
ADCPPDLILVLYSIGVKHKKQGYSNKEWPISGGAWNLGAQTYPEIIITGHADGSIKFWDASAITLQMLYKLKTSKVFEKQKVGEGKQTCE
IVEEDPFAIQMIYWCPESRIFCVSGVSAYVIIYKFSRHEITTEIVSLEVRLQYDVEDIITPEPETSPPFPDLSAQLPSSRSLSGSTNTVA
SEGVTKDSIPCLNVKTRPVRMPPGYQAELVIQLVWVDGEPPQQITSLAVSSAYGIVAFGNCNGLAVVDFIQKTVLLSMGTIDLYRSSDLY
QRQPRSPRKNKQFIADNFCMRGLSNFYPDLTKRIRTSYQSLTELNDSPVPLELERCKSPTSDHVNGHCTSPTSQSCSSGKRLSSADVSKV
NRWGPGRPPFRKAQSAACMEISLPVTTEENRENSYNRSRSSSISSIDKDSKEAITALYFMDSFARKNDSTISPCLFVGTSLGMVLIISLN
LPLADEQRFTEPVMVLPSGTFLSLKGAVLTFSCMDRMGGLMQPPYEVWRDPNNIDENEKSWRRKVVMNSSSASQEIGDHQYTIICSEKQA

--------------------------------------------------------------
>53133_53133_5_METTL4-STXBP5L_METTL4_chr18_2544194_ENST00000574538_STXBP5L_chr3_120941850_ENST00000497029_length(transcript)=4100nt_BP=2049nt
CTGGAAGGCTGCGTGCTGGTCGCGCCCAGCTGCGTCACCCCAGGAACTGGGGTCTGTGGGCCAGTGTGGCCGTCTCTACGAAGACTGGCA
CGACCCCTAAAGTTAGGTCGGAAGACCTGTGGGCAGCTTGAGCGCCGAGGAGTGCCCTGAACGCTCAACTCGCCCTGGAAACGTTTTTCC
GTACAGCAACATGGCGGCGCCCATGGACTCTTAGAAAAGGAGAAAGCTTTTTCTCTGTGGACTGGAAGGGGCATTTTTCATGATCACTAT
TTAGATGGGTGCTGTTTTCATGAGGAGAGTCTGGGAAGGCGGCGTCCGCTTTTCTGACAAGGGAAGAGGCTACTTTGTCCTTTTAAGGAT
TCAATGACTTCCTGACTTGGAGGATGTGGACCTAGTGGCTAGACCCAAGGACCAAAGCAAGAAGTCGTGGGGGGCCCAGGAAGACAGGAG
GATCACATTGGGATTCCAGACATAAGATCAGGTTTTAACCCCCTTTGGCCAAATTTTGGCTGAAAATGTTGAATTATCAACTCTGAAATT
AAAAAGAAAGTTTATATTAAAACATTGCAATTTTCCTTAGAATTTCTGTATATATTAACATCATGAATGATAAATTCTCTTCAATGTGCA
TGTCAGGTTTTTGTACTTGTATATCAAATCTATCTGTGTGTATGAAGTGTATGTTTATTGAAATACAAGATATTTAAGAAGCTGATCTGG
AAAGTTGGATTTTCATTCTAGTTCCTAATTCCCAGAGGCTTTTTTAAAGGAAGGGAATGTCTGTGGTACACCAGTTGTCAGCTGGGTGGT
TACTGGATCATCTTTCTTTTATCAACAAGATAAACTATCAACTTCACCAGCATCATGAACCTTGTTGCCGTAAAAAGGAGTTCACTACTT
CTGTTCACTTTGAGTCTCTTCAAATGGATTCTGTGTCCTCCTCTGGAGTCTGTGCTGCATTTATTGCTTCTGACTCTTCCACTAAGCCAG
AGAATGATGATGGAGGAAATTATGAAATGTTCACACGAAAATTTGTTTTTCGACCTGAACTGTTTGATGTCACCAAACCTTATATAACTC
CAGCTGTTCATAAAGAATGCCAGCAAAGTAATGAAAAGGAAGATCTGATGAATGGTGTTAAAAAAGAAATCTCCATTTCTATTATTGGGA
AGAAGCGTAAAAGATGTGTTGTTTTCAATCAAGGTGAATTGGATGCTATGGAATACCATACAAAGATCAGGGAGCTGATTTTGGATGGAT
CTTTACAGTTGATCCAGGAAGGTCTCAAAAGTGGTTTTCTTTATCCACTTTTTGAAAAACAGGACAAGGGTAGTAAGCCCATTACTTTAC
CACTTGACGCCTGCAGTTTGTCAGAATTATGTGAAATGGCAAAGCATTTGCCTTCTCTGAATGAAATGGAACATCAGACATTACAATTGG
TGGAAGAGGATACATCTGTTACAGAACAGGATTTATTTTTGCGAGTTGTTGAAAACAACTCTAGCTTTACAAAAGTGATTACTTTAATGG
GACAGAAATACCTGCTACCACCGAAAAGCAGTTTTCTTTTATCTGACATTTCTTGTATGCAACCACTTCTAAACTATAGGAAAACATTTG
ATGTAATTGTGATAGATCCACCATGGCAGAACAAATCAGTTAAAAGAAGTAATAGGTACAGTTATTTGTCACCCCTGCAAATACAGCAAA
TACCTATCCCTAAATTGGCTGCTCCAAACTGTCTTCTTGTTACTTGGGTGACCAATAGACAGAAGCACCTACGTTTTATAAAGGAAGAAC
TTTATCCCTCTTGGTCTGTGGAGGTAGTTGCTGAGTGGCACTGGGTAAAAATAACCAATTCAGGAGAATTTGTGTTCCCATTAGATTCTC
CACACAAAAAGCCCTACGAAGGTCTTATACTGGGGAGGGTTCAAGAAAAAACTGCTCTACCATTGAGGAATGCAGATGTAAACGTGCTCC
CCATTCCAGACCACAAATTAATTGTCAGCGTGCCCTGTACTCTTCACTCACATAAGCCACCGCTTGCTGCGAACCATTCATAATATTCTC
TGGTGGGCTGTCCTATGACAAAGCTTGTAGAAGACCAAGTTTAACCATCATGCATGGAAAAGCAATTACAGTACTTGAAATGGATCATCC
TATTGTTGAATTTCTAACTTTATGTGAAACGCCCTATCCAAATGAATTTCAAGAACCCTATGCTGTCGTGGTACTTCTGGAGAAAGATCT
CATTGTAGTTGATCTGACACAAAGCAATTTTCCAATCTTTGAAAATCCATATCCCATGGACATTCATGAATCACCAGTTACATGCACAGC
ATACTTTGCAGATTGTCCTCCGGATTTGATTCTAGTACTGTATTCTATAGGAGTCAAGCATAAAAAACAAGGATACAGTAATAAGGAGTG
GCCAATCAGTGGAGGAGCTTGGAACCTTGGAGCACAAACATATCCAGAAATTATTATTACTGGTCATGCAGATGGATCAATAAAATTTTG
GGATGCTTCTGCAATAACTCTGCAGATGCTGTACAAGCTAAAAACTTCAAAAGTGTTTGAAAAACAGAAGGTAGGAGAAGGAAAACAAAC
ATGTGAAATTGTAGAGGAAGACCCATTTGCCATTCAGATGATTTACTGGTGTCCAGAGAGCAGAATATTCTGTGTATCAGGAGTCTCTGC
ATATGTCATAATTTATAAATTCAGCAGACATGAAATTACAACAGAAATAGTGTCATTAGAGGTACGACTTCAGTATGATGTTGAAGATAT
TATTACCCCTGAACCAGAAACAAGTCCTCCGTTTCCAGATCTCTCAGCCCAGCTTCCTTCTTCAAGGAGTCTTTCTGGGAGCACTAACAC
TGTTGCTAGTGAAGGAGTAACAAAGGACAGTATTCCATGCCTCAATGTGAAGACACGGCCAGTGCGAATGCCTCCAGGATATCAAGCAGA
ACTTGTTATTCAATTGGTGTGGGTAGATGGTGAACCTCCACAACAGATTACTAGTCTTGCTGTAAGCTCAGCATATGGAATAGTTGCATT
TGGGAACTGCAATGGGTTGGCTGTGGTGGATTTTATACAGAAGACAGTACTGTTAAGCATGGGGACCATTGACCTATATAGATCAAGTGA
CTTATACCAGCGACAACCACGGTCTCCTCGAAAAAACAAACAGTTCATTGCAGACAACTTTTGCATGCGTGGCCTGTCTAACTTTTATCC
TGATTTAACGAAACGGATCCGTACTTCCTATCAGAGTTTAACTGAACTGAATGACAGTCCAGTTCCCCTAGAACTTGAGCGCTGCAAGTC
TCCTACCTCAGGACTTGCTACCAGAACCCCTGAGTCAGCACTAGGCTTTTATAGGAATGAAATATCAGCTATGAGACAGAGGAATCAAGT
ATATCACTTGCCAGAAAACCGAGAAAATTCCTATAATCGTTCTAGAAGCTCTAGTATCTCCAGTATTGACAAAGATTCTAAAGAAGCAAT
TACAGCACTATACTTCATGGACTCCTTTGCACGGAAAAATGACTCTACCATCTCTCCTTGTCTGTTCGTTGGAACCAGTCTGGGAATGGT
GTTAATCATCTCCTTAAACCTACCATTAGCAGATGAACAAAGGTTTACAGAGCCAGTCATGGTATTGCCAAGTGGTACATTCCTCTCATT
GAAAGGAGCTGTGCTAACATTCTCCTGTATGGACCGAATGGGTGGATTAATGCAACCGCCATATGAAGTTTGGAGGGATCCAAACAACAT
AGATGAAAATGAAAAATCTTGGAGAAGGAAAGTGGTAATGAACTCATCTTCTGCATCCCAAGAAATAGGAGATCATCAGTATACAATAAT
CTGCTCAGAAAAACAAGCCAAAGTCTTCTCACTGCCTTCTCAGACTTGCCTTTATGTTCATAACATCACGGAGACATCTTTTATACTGCA
AGCAAATGTGGTGGTCATGTGTAGCAGTGCCTGCTTGGCATGCTTTTGTGCTAACGGACATATCATGATAATGAGGTACTTGCCTTCTTA

>53133_53133_5_METTL4-STXBP5L_METTL4_chr18_2544194_ENST00000574538_STXBP5L_chr3_120941850_ENST00000497029_length(amino acids)=672AA_BP=
MSYDKACRRPSLTIMHGKAITVLEMDHPIVEFLTLCETPYPNEFQEPYAVVVLLEKDLIVVDLTQSNFPIFENPYPMDIHESPVTCTAYF
ADCPPDLILVLYSIGVKHKKQGYSNKEWPISGGAWNLGAQTYPEIIITGHADGSIKFWDASAITLQMLYKLKTSKVFEKQKVGEGKQTCE
IVEEDPFAIQMIYWCPESRIFCVSGVSAYVIIYKFSRHEITTEIVSLEVRLQYDVEDIITPEPETSPPFPDLSAQLPSSRSLSGSTNTVA
SEGVTKDSIPCLNVKTRPVRMPPGYQAELVIQLVWVDGEPPQQITSLAVSSAYGIVAFGNCNGLAVVDFIQKTVLLSMGTIDLYRSSDLY
QRQPRSPRKNKQFIADNFCMRGLSNFYPDLTKRIRTSYQSLTELNDSPVPLELERCKSPTSGLATRTPESALGFYRNEISAMRQRNQVYH
LPENRENSYNRSRSSSISSIDKDSKEAITALYFMDSFARKNDSTISPCLFVGTSLGMVLIISLNLPLADEQRFTEPVMVLPSGTFLSLKG
AVLTFSCMDRMGGLMQPPYEVWRDPNNIDENEKSWRRKVVMNSSSASQEIGDHQYTIICSEKQAKVFSLPSQTCLYVHNITETSFILQAN

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for METTL4-STXBP5L

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for METTL4-STXBP5L

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for METTL4-STXBP5L

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source