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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:METTL9-GSPT1 (FusionGDB2 ID:53146)

Fusion Gene Summary for METTL9-GSPT1

check button Fusion gene summary
Fusion gene informationFusion gene name: METTL9-GSPT1
Fusion gene ID: 53146
HgeneTgene
Gene symbol

METTL9

GSPT1

Gene ID

51108

2935

Gene namemethyltransferase like 9G1 to S phase transition 1
SynonymsCGI-81|DREV|DREV1|PAP1551G9.2|ETF3A|GST1|eRF3a
Cytomap

16p12.2

16p13.13

Type of geneprotein-codingprotein-coding
Descriptionmethyltransferase-like protein 9CTB-31N19.3DORA reverse strand protein 1p53 activated protein 1eukaryotic peptide chain release factor GTP-binding subunit ERF3AG1 to S phase transition protein 1 homologeukaryotic peptide chain release factor subunit 3aeukaryotic release factor 3a
Modification date2020031320200313
UniProtAcc

Q9H1A3

P15170

Ensembl transtripts involved in fusion geneENST00000358154, ENST00000396014, 
ENST00000563026, 		ENST00000420576, 
ENST00000563468, ENST00000564790, 
ENST00000434724, ENST00000439887, 
Fusion gene scores* DoF score6 X 4 X 3=728 X 8 X 6=384
# samples 613
** MAII scorelog2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/384*10)=-1.5625946876927
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: METTL9 [Title/Abstract] AND GSPT1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMETTL9(21636436)-GSPT1(11991892), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGSPT1

GO:0006479

protein methylation

18539146


check buttonFusion gene breakpoints across METTL9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GSPT1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-D7-A4Z0-01AMETTL9chr16

21636436

+GSPT1chr16

11991892

-


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Fusion Gene ORF analysis for METTL9-GSPT1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000358154ENST00000420576METTL9chr16

21636436

+GSPT1chr16

11991892

-
5CDS-5UTRENST00000396014ENST00000420576METTL9chr16

21636436

+GSPT1chr16

11991892

-
5CDS-intronENST00000358154ENST00000563468METTL9chr16

21636436

+GSPT1chr16

11991892

-
5CDS-intronENST00000358154ENST00000564790METTL9chr16

21636436

+GSPT1chr16

11991892

-
5CDS-intronENST00000396014ENST00000563468METTL9chr16

21636436

+GSPT1chr16

11991892

-
5CDS-intronENST00000396014ENST00000564790METTL9chr16

21636436

+GSPT1chr16

11991892

-
In-frameENST00000358154ENST00000434724METTL9chr16

21636436

+GSPT1chr16

11991892

-
In-frameENST00000358154ENST00000439887METTL9chr16

21636436

+GSPT1chr16

11991892

-
In-frameENST00000396014ENST00000434724METTL9chr16

21636436

+GSPT1chr16

11991892

-
In-frameENST00000396014ENST00000439887METTL9chr16

21636436

+GSPT1chr16

11991892

-
intron-3CDSENST00000563026ENST00000434724METTL9chr16

21636436

+GSPT1chr16

11991892

-
intron-3CDSENST00000563026ENST00000439887METTL9chr16

21636436

+GSPT1chr16

11991892

-
intron-5UTRENST00000563026ENST00000420576METTL9chr16

21636436

+GSPT1chr16

11991892

-
intron-intronENST00000563026ENST00000563468METTL9chr16

21636436

+GSPT1chr16

11991892

-
intron-intronENST00000563026ENST00000564790METTL9chr16

21636436

+GSPT1chr16

11991892

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000358154METTL9chr1621636436+ENST00000434724GSPT1chr1611991892-75621009212570849
ENST00000358154METTL9chr1621636436+ENST00000439887GSPT1chr1611991892-30081009212567848
ENST00000396014METTL9chr1621636436+ENST00000434724GSPT1chr1611991892-748092722488828
ENST00000396014METTL9chr1621636436+ENST00000439887GSPT1chr1611991892-292692722485827

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000358154ENST00000434724METTL9chr1621636436+GSPT1chr1611991892-0.0002407750.99975926
ENST00000358154ENST00000439887METTL9chr1621636436+GSPT1chr1611991892-0.0007619830.999238
ENST00000396014ENST00000434724METTL9chr1621636436+GSPT1chr1611991892-0.0001736550.9998264
ENST00000396014ENST00000439887METTL9chr1621636436+GSPT1chr1611991892-0.0004907840.9995092

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Fusion Genomic Features for METTL9-GSPT1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for METTL9-GSPT1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:21636436/chr16:11991892)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
METTL9

Q9H1A3

GSPT1

P15170

FUNCTION: Involved in translation termination in response to the termination codons UAA, UAG and UGA (By similarity). Stimulates the activity of ETF1 (By similarity). Involved in regulation of mammalian cell growth (PubMed:2511002). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:24486019). Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371). {ECO:0000250|UniProtKB:Q8IYD1, ECO:0000269|PubMed:24486019, ECO:0000269|PubMed:2511002, ECO:0000269|PubMed:30682371}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMETTL9chr16:21636436chr16:11991892ENST00000358154+4544_47250319.0Compositional biasNote=Poly-Ala
HgeneMETTL9chr16:21636436chr16:11991892ENST00000396014+4544_47250318.0Compositional biasNote=Poly-Ala
TgeneGSPT1chr16:21636436chr16:11991892ENST0000042057601572_2980500.0Domaintr-type G
TgeneGSPT1chr16:21636436chr16:11991892ENST0000056346801372_2980500.0Domaintr-type G
TgeneGSPT1chr16:21636436chr16:11991892ENST00000420576015158_1620500.0Nucleotide bindingGTP
TgeneGSPT1chr16:21636436chr16:11991892ENST00000434724015158_162117638.0Nucleotide bindingGTP
TgeneGSPT1chr16:21636436chr16:11991892ENST00000439887015158_162117637.0Nucleotide bindingGTP
TgeneGSPT1chr16:21636436chr16:11991892ENST00000563468013158_1620500.0Nucleotide bindingGTP
TgeneGSPT1chr16:21636436chr16:11991892ENST00000420576015137_1410500.0RegionG2
TgeneGSPT1chr16:21636436chr16:11991892ENST00000420576015158_1610500.0RegionG3
TgeneGSPT1chr16:21636436chr16:11991892ENST00000420576015220_2230500.0RegionG4
TgeneGSPT1chr16:21636436chr16:11991892ENST00000420576015262_2640500.0RegionG5
TgeneGSPT1chr16:21636436chr16:11991892ENST0000042057601581_880500.0RegionG1
TgeneGSPT1chr16:21636436chr16:11991892ENST00000434724015137_141117638.0RegionG2
TgeneGSPT1chr16:21636436chr16:11991892ENST00000434724015158_161117638.0RegionG3
TgeneGSPT1chr16:21636436chr16:11991892ENST00000434724015220_223117638.0RegionG4
TgeneGSPT1chr16:21636436chr16:11991892ENST00000434724015262_264117638.0RegionG5
TgeneGSPT1chr16:21636436chr16:11991892ENST00000439887015137_141117637.0RegionG2
TgeneGSPT1chr16:21636436chr16:11991892ENST00000439887015158_161117637.0RegionG3
TgeneGSPT1chr16:21636436chr16:11991892ENST00000439887015220_223117637.0RegionG4
TgeneGSPT1chr16:21636436chr16:11991892ENST00000439887015262_264117637.0RegionG5
TgeneGSPT1chr16:21636436chr16:11991892ENST00000563468013137_1410500.0RegionG2
TgeneGSPT1chr16:21636436chr16:11991892ENST00000563468013158_1610500.0RegionG3
TgeneGSPT1chr16:21636436chr16:11991892ENST00000563468013220_2230500.0RegionG4
TgeneGSPT1chr16:21636436chr16:11991892ENST00000563468013262_2640500.0RegionG5
TgeneGSPT1chr16:21636436chr16:11991892ENST0000056346801381_880500.0RegionG1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGSPT1chr16:21636436chr16:11991892ENST0000043472401572_298117638.0Domaintr-type G
TgeneGSPT1chr16:21636436chr16:11991892ENST0000043988701572_298117637.0Domaintr-type G
TgeneGSPT1chr16:21636436chr16:11991892ENST0000043472401581_88117638.0RegionG1
TgeneGSPT1chr16:21636436chr16:11991892ENST0000043988701581_88117637.0RegionG1


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Fusion Gene Sequence for METTL9-GSPT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>53146_53146_1_METTL9-GSPT1_METTL9_chr16_21636436_ENST00000358154_GSPT1_chr16_11991892_ENST00000434724_length(transcript)=7562nt_BP=1009nt
GGCCGCTCGTAAGTGCTCCGGATGGAAACTGGTGCAGGGGGCAGCGGCGTTCCGCGGCCGGAAGGGAAGGGGGAGGTGCCGAGGCTGCGC
GCCGGCTGCTCCTCCCCACCCCCAGCCTTTGCCCTGAAGGGGGCTGGATGGGCAAGGCGGCCGCGATGGCTCGAGCTCGGGCGGTGGCGG
CGGTGGCCGGAGGCGGCGGTGCCTCCTCCTCCTCGCCCCGGCGCCGGCGGTGATCCGAGCGAGCGGCCGCGGCCCCCGATGAGACTGCTG
GCGGGCTGGCTGTGCCTGAGCCTGGCGTCCGTGTGGCTGGCGCGGAGGATGTGGACGCTGCGGAGCCCGCTCACCCGCTCCCTGTACGTG
AACATGACTAGCGGCCCGGGTGGGCCGGCGGCGGCCGCGGGCGGCAGGAAGGAGAACCACCAGTGGTATGTGTGCAACAGAGAGAAATTA
TGCGAATCACTCCAGGCTGTCTTTGTTCAGAGTTACCTTGATCAAGGAACACAGATCTTCTTAAACAACAGCATTGAGAAATCGGGCTGG
CTATTTATCCAATTATATCATTCTTTTGTGTCATCTGTTTTTAGCCTGTTTATGTCTAGAACATCTATCAATGGGTTGCTAGGAAGAGGC
TCAATGTTTGTGTTTTCACCAGATCAGTTTCAGAGACTGCTTAAAATTAATCCAGACTGGAAAACCCACAGACTTCTTGATTTAGGTGCT
GGAGATGGAGAAGTCACAAAAATCATGAGCCCTCATTTTGAAGAAATCTATGCCACTGAGCTTTCTGAAACTATGATATGGCAGCTTCAG
AAAAAGAAATACAGAGTCCTTGGTATAAATGAATGGCAGAATACGGGGTTCCAGTATGATGTCATCAGCTGCCTGAACTTGCTGGACCGC
TGTGATCAGCCCCTGACTTTGTTAAAAGATATCAGAAGTGTCTTGGAGCCAACTAGAGGCAGGGTCATCCTTGCCCTTGTCCTCCCCTTT
CATCCCTATGTGGAAAACGCACCTGTGGAATCCTCTCAAGAGGAACAGTCATTGTGTGAAGGTTCAAATTCAGCTGTTAGCATGGAACTT
TCAGAACCTATTGTAGAAAATGGAGAGACAGAAATGTCTCCAGAAGAATCATGGGAGCACAAAGAAGAAATAAGTGAAGCAGAGCCAGGG
GGTGGTTCCTTGGGAGATGGAAGGCCGCCAGAGGAAAGTGCCCATGAAATGATGGAGGAGGAAGAGGAAATCCCAAAACCTAAGTCTGTG
GTTGCACCGCCAGGTGCTCCTAAGAAAGAGCATGTAAATGTAGTATTCATTGGGCACGTAGATGCTGGCAAGTCAACCATTGGAGGACAA
ATAATGTATTTGACTGGAATGGTTGACAAAAGGACGCTTGAAAAGTATGAAAGAGAAGCTAAAGAGAAAAACAGAGAAACTTGGTACTTG
TCTTGGGCCTTAGACACAAATCAGGAAGAACGAGACAAGGGTAAAACAGTAGAAGTGGGTCGTGCCTATTTTGAAACCGAAAAGAAGCAT
TTCACAATTCTAGATGCCCCTGGCCACAAGAGTTTTGTCCCAAATATGATTGGTGGTGCCTCTCAAGCTGATTTGGCTGTGCTGGTAATC
TCAGCCAGGAAAGGAGAGTTTGAAACTGGATTTGAAAAAGGAGGACAGACAAGAGAACATGCAATGTTGGCAAAGACAGCAGGTGTAAAA
CACCTAATTGTGCTAATTAATAAGATGGATGATCCAACAGTAAATTGGAGCAATGAGAGATATGAAGAATGTAAGGAGAAACTAGTGCCA
TTTTTGAAAAAAGTTGGCTTCAATCCCAAAAAGGACATTCACTTTATGCCCTGCTCAGGACTTACTGGAGCAAATCTCAAAGAGCAGTCG
GATTTCTGTCCTTGGTACATTGGATTACCGTTTATTCCATATCTGGATAATTTGCCGAACTTCAATAGATCAGTTGATGGACCAATCAGG
CTGCCAATTGTGGATAAGTACAAGGATATGGGCACTGTGGTCCTGGGAAAGCTGGAATCAGGATCTATTTGTAAAGGCCAGCAGCTTGTG
ATGATGCCAAACAAGCACAACGTGGAAGTTCTTGGAATACTTTCCGATGATGTAGAGACTGATACCGTAGCCCCAGGTGAAAACCTCAAA
ATCAGACTGAAAGGAATTGAAGAAGAGGAGATTCTTCCAGGGTTTATACTTTGTGATCCTAATAATCTTTGTCATTCTGGACGCACATTT
GATGCCCAGATAGTGATTATAGAGCACAAATCCATCATCTGCCCAGGCTATAATGCGGTGCTGCATATTCATACCTGTATTGAGGAGGTG
GAAATAACAGCCTTAATCTGCTTGGTAGACAAAAAATCAGGAGAAAAAAGTAAGACCCGACCCCGTTTTGTCAAACAAGATCAAGTATGC
ATTGCTCGCTTAAGGACAGCAGGAACCATCTGCCTTGAGACCTTTAAAGACTTCCCTCAGATGGGTCGTTTCACCTTAAGAGATGAGGGT
AAGACCATTGCAATTGGAAAAGTTCTGAAACTGGTTCCAGAGAAAGACTAAGCATTTTCTTGATGACCCTGCACAATACTGTGAGGAAAA
TTGACTGCAGAAGCCTACTTCACACCGCCTTCTCTTATTTTCTGCCCATTGATAAACCTCTCCCCATATTTTGCAAAGAGGAAATTCACA
GCAAAAGTCCACATTATGTCAGCTTTCTCATATTGAGAGCTCTGCTATGCCACTGTTGAATTTTTCCCAAGATTCCTGTCCCTAGCCCTC
ACTTCAAACTCTGCTTCCTTGGACAGATTTGGCAATAGCTTTGTAAGTGATGTGGACATAATTGCCTACAATAATGAAAACCTACAGGAA
TTTTTTTATTTTTCATTTTCCCCTTAGGCATATTTAGTATTTTTCCCCCAGGCAGATCATTCTGAGTGTGCGAGTGTGTGTGCACATGTT
ACAAAGGCAACTACCATGTTAATAAAATATTCAATTTGAAATCCTTTTCGGTATTTGAATTGCTTTTGAATAATGTTTTTTATCTGGATG
TAACATTGTTGCATTAGCTTTTTAACTTTCCCAAGTAATTGAATACATTTTATTACTTGGACTTTTATAAACTCTTTCCCTACCCACTAT
AAATGAGACATTCACAGCGTTCAAGTTTGTATTAAAGGAAAGGATTAGTTTGACCCCTTCTTTTGATGGTTAATGCATACATGCAGTTAA
ATCCCTTTATGCAAATGTGACACTGCTTTACTAGGTCTTTTAGTTATTTATTTATTTTTTTTTTTTTTGCCAATTTATATTGTAACATGA
TTTCTTGAACACAGTAAGTTGTTTTAAAATAAAAGAACAGCATACTGTAGTTTTTATAAGTAAAGCGTAATGAAATTGTACCCCTAGAGA
AAATTCCATTAACTTGTTAAATTAGTGGAATTAACAACAAATAAAGCATGTTTGAGACCTGGCAAAAATTCCTCTGGTAGTATTTATAAA
TAGAGCTGCATGCCTCTAGTATGAAAACCGTATCAGTTGCAAGTGCCACTTCTACAAGTTACTCAGTTTACTCTTTGTATCAGTAACTTT
AAAGGTTGGATGATCCTTGCTGGTTAAAGCTAAATCTCAACCTAGCAACTAAATGAAAATATTTAGAATCATCAGAATCTGAACAGACTA
AAATTATCAGCGATAAGCAGAATCAAGCAGGGTATAAGTTTTATCTCAATTATTTGAAATTGACTGAGTTTTCTTAAGTGTAAAGCTGAA
ATTTGCTAACCATGTTTTTGATGAACCACAGTGCAGCATTGTGTGGGTTTTAGATTGAATGACTCTCTGCTATAATTATCATGACTTTGA
AATTTTTCATGAGAATAAATGAGGAATGGAGGCAATTTGTGGGTTTATCCAAAGCCCCCTTGATGTTGAGTGTTGCCATTGATCAAAGAT
AGCCTCTTTTAGATTGTGATTTCTCTCTAAATAAGATACTTTGTATATTTAATGACAAGTCTCTTCCCTATAATTTTGCTCCTCAGAAAA
GAAAAGCCTAGACAGACTGTATTTCCAGTCACAGAACATAAAACTTAATCTAATGGGTGTTTTGTTTTGTTTTGAGACAGAGGCTCACTC
TGTCACCTAGGCTGGAGTGCAGTGGCTCGATCTCAGCTCACTGCAGCCTCCACCTCCCGGATTCAAGCAATTTCCTGCCTCAGCCTCTTG
AGTAGCTGGGATTACAGGAGCCCTCCACGAGGCCCAGTTAATTTTTGTATCTTTAGTGGAGACGAGGTTTCCCCCTATTGGTCAGGCTGG
TCTCAAACTTCTGACCTCAAGTGATCCACTCGCCTCAGCCTCTCAAAAGTGCTGGGATTACAGGCATGAGGCGCCGCACTTGGCCTAGTG
TTTTCTTAACTGTGAAATTCCCATTCATTTCTTGAATGAGGCTACATCTTATGGACAGAGCAAAGTTATTGTCCTACAGATTCTTAAAAC
TATAATTATGGCTATTGCATGAAATTTAAATAGATTTTATTATGTCTGCAAATCTCTGGGCTTTTATTTTTCTGGAAAATATAGGAGCTT
TAATCAAAACATAATAGTTCTTTTTGTAATTCCATGTTAATAAAAACAAATACTAGCAATTGCTTGAATTTTAATGAATATTTAAAAGTT
CAAGAGCCACGGAAATCACTTCCAGAGATAAGAGTTCCCTTTCTAAATAGAACACATTTTTAAAAAATAAGTTATGTTTGCTACTAAAAC
ATTTACACTGTTAGACTATTATGTGCATGTTGCCAAGACTCTTAAGTAACTTGGATATCAACTGTGAAGGGCCTACCTCTAAAAAGTAAC
AGGTCATACAAATACAAATGTAACTGTAAAAATTCCACTGGATTCTTGCATATTTGCAAGATTAGATTATTCAAAAGAAATTTCAGTGCT
AAAATTAACCAGCAACATAAGTTCTATGGGCTTTGAAAATTGTTCTCATCTTTTTAAAGTTGATGCATTTTCAATCCTGCTTACACAGGC
TGTTCATTTGGATAAGTAAATAAAATGTCTAAGGTGAACTTGGCATTATGTGGAGATGTTGGACCGTTATAGAGCAATACAAATTCCTAT
GCTGTCATTCTGTTTTCTGCAAATGCAAACGTGCTTATATGGTCAACAGTGCAAAAATAGGGTAGTTGGCTGCATATTTAGGGTATTACC
TAAGCATTTGTTCTCTAACGTTGCTCTACTAGAATGATTTTTTTCTTGCATCTTTTCACATTAATGATGTTCTTTATATAACTTTCATGC
GATTATTTAGTTTTTTAAATTAATAAAGTGAATTTAAGAAATATTGAAATAAACATCTAAGTAATTGCCATTTTAAACCCTTGTTTCTTA
CTGTGGGAGAGGGGGAAATACAGCACTCATTTCTTGTTTTTAATTTGCAGAAGTAAGTGAAAATCTATGTAAAATCAAACCAAAAGAGTT
GGACTGAGTGTGTATTGTCTTGAGATTAAGTGACAAATAGTAAAGTGTTACTGAGTAATTAAGCCCATGTATTTTTTTTTTGTGAGTTGA
AAATCTTTGAAATATGTGATAACCGAATGTCAAAAGTTCCTAAACTCTAACAGTGCAGGTTGTTCACTGTAACGAGGTAACTCATATTTG
CTGGTTACATAAACTACAAGTACTGCTCTCACAATATGGGACTTTGAACTGTGATGTAGTTCAACAGTTGCCGGCATCCTCTCAGCTGAT
ACGCTGCGAATATTTTGGGTTAGACTTGCAGCCAGATGCAGTTTTGCAACCCAAGAAAAAAGTTGAACCTATGATCAAAAACTGCTCCCA
AGATGAACCTGGAAAAAAATCAGCTAAGCTCCCTTGGCGATCTGCAGGAACACTAGTAATGACTGGAATTACTCCGTGATCTTTGATGAC
TATTACACATAACAGCACTCTAGCACCTTTTCTTACTGGCATGGACTTCCTCATGGACTGCTACTTCATGGATGATAGCTTCATTGCTTT
GGGTAGGGATTTAAGGTAGTCAAGGGGAAAATACGCAGTTTTATTACAGGTCTTAACATCAGGCAACTTTCAACTTTAAAACCCTTTGTG
AAAAATGTGGTTATAGCACTATAGCTCTGATTTTAGGATGGTTAAATGTTATATTCATTGTTGGCTTACCTTATCAAACTGTGCCATTAA
TCCTTTCACAGACATAGGTAAGGAAGAGAACAACCAGTGGATTCAGGGGACAATTATCTATCTCCAAATAATAGGCTTTTATTTCTTGCA
GCTAACTTTTTCAGTGATTCTAGCAGATGCCATCTAGTACATCCTTGATCTTGTTTCTTTCGTGAGAGATCTCGCCATGGCAGCATCTTG
TTAAGTAAGTGTAATTGCACATGCACAAAAGACTTAACTAGCTTTACATTTAGCAGTCAGTTGGTTAGATTAGGTTTCATAGTAAATGAA
TAGGAATAGAAAGAATAGGAAGTGTTTTTATTTTCCAGTAGTAATTCCGTGGATTCCATTTGACCCAGTTTACTATCAGTTCAGTTCAGG
TAGATTTGGTTCAACTTTTGGTGGTTTTTGGCTCTAGGATATTCTTGACTTTAATATCCTAGAACTTACTGAGTCTTCCCTTCAATAAAT
ACACTTCTCACATACCTCTAATCCTATGCTTCCTTGAAACAATAATGCTAGCTGAGTTGTTTACTAAGGATTATTATAAGGGCCTGAAGG
TGTGGGAGTGGAGATTAATTAAAACCTTTATGTTCTCCAATATAAGGGAAAAGCAGGTTGGTACTACTTCTGATTAGGCAGAAAACACCA
GGATTCCTTAAGTGATCCTTGAAATGGTTATTGTTTTCTGCCTTGTCACATTTGCCACTGTGCCCTTTAAAACGATGTGGAAACCTCAGG
TTTGTGGACAGCACAGGTGGAATGACATCTTGTGCTTCCTGAGGCTCCCCTCTACCAGGCACATTAGCTTAGTGCTTCAGATGTCAGCCC
AAGTCCTTGTTACCTCCTTTTCCTGCTGCCCAGGGAAGAGTGTGTGTGCTGGAGCTGGAGCGCTTGCACTCTTCAGGTGACTATTCTCAC
CTCCATTTCCTCCACATGCATTAGGTGAAACTGAGGTCTAAGCCTCCTGCAAGGTCTACATTTTAAGGACTCACACATCAGGCTCTCAGA
AATGTACACAGGTATTAGTTCTGTTTGTTCTAAAGGAAATGTGGGTATCTCTCAGGCCAGGACTTAGTGACTAGTTTTCGCTAGACAGCA
GGTTAATACCTAGATCTCATTTAAAAAAAAAAAAAAAAAACAGGATTAAAGGGAACTGATCAGGTTTGTTGAGTTTTTTAGCCTAATTCC
AAAGCATGGAAGAGTGCTCTAGGTAGGAAAGAAAGCTTTTTCTTACGATTTGTAGCTACCTACTGTGCCTGACTTGGTGCCTGTGTGAGG
ATTAAGCCCTTAGTCTGCTCTTGCAATTATTCAAATGACAAATTAAATTTGCTTTTGTAATAACAATAAAAGTTGTCATCTTCCCTTTTG

>53146_53146_1_METTL9-GSPT1_METTL9_chr16_21636436_ENST00000358154_GSPT1_chr16_11991892_ENST00000434724_length(amino acids)=849AA_BP=46
METGAGGSGVPRPEGKGEVPRLRAGCSSPPPAFALKGAGWARRPRWLELGRWRRWPEAAVPPPPRPGAGGDPSERPRPPMRLLAGWLCLS
LASVWLARRMWTLRSPLTRSLYVNMTSGPGGPAAAAGGRKENHQWYVCNREKLCESLQAVFVQSYLDQGTQIFLNNSIEKSGWLFIQLYH
SFVSSVFSLFMSRTSINGLLGRGSMFVFSPDQFQRLLKINPDWKTHRLLDLGAGDGEVTKIMSPHFEEIYATELSETMIWQLQKKKYRVL
GINEWQNTGFQYDVISCLNLLDRCDQPLTLLKDIRSVLEPTRGRVILALVLPFHPYVENAPVESSQEEQSLCEGSNSAVSMELSEPIVEN
GETEMSPEESWEHKEEISEAEPGGGSLGDGRPPEESAHEMMEEEEEIPKPKSVVAPPGAPKKEHVNVVFIGHVDAGKSTIGGQIMYLTGM
VDKRTLEKYEREAKEKNRETWYLSWALDTNQEERDKGKTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKGEF
ETGFEKGGQTREHAMLAKTAGVKHLIVLINKMDDPTVNWSNERYEECKEKLVPFLKKVGFNPKKDIHFMPCSGLTGANLKEQSDFCPWYI
GLPFIPYLDNLPNFNRSVDGPIRLPIVDKYKDMGTVVLGKLESGSICKGQQLVMMPNKHNVEVLGILSDDVETDTVAPGENLKIRLKGIE
EEEILPGFILCDPNNLCHSGRTFDAQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALICLVDKKSGEKSKTRPRFVKQDQVCIARLRTA

--------------------------------------------------------------
>53146_53146_2_METTL9-GSPT1_METTL9_chr16_21636436_ENST00000358154_GSPT1_chr16_11991892_ENST00000439887_length(transcript)=3008nt_BP=1009nt
GGCCGCTCGTAAGTGCTCCGGATGGAAACTGGTGCAGGGGGCAGCGGCGTTCCGCGGCCGGAAGGGAAGGGGGAGGTGCCGAGGCTGCGC
GCCGGCTGCTCCTCCCCACCCCCAGCCTTTGCCCTGAAGGGGGCTGGATGGGCAAGGCGGCCGCGATGGCTCGAGCTCGGGCGGTGGCGG
CGGTGGCCGGAGGCGGCGGTGCCTCCTCCTCCTCGCCCCGGCGCCGGCGGTGATCCGAGCGAGCGGCCGCGGCCCCCGATGAGACTGCTG
GCGGGCTGGCTGTGCCTGAGCCTGGCGTCCGTGTGGCTGGCGCGGAGGATGTGGACGCTGCGGAGCCCGCTCACCCGCTCCCTGTACGTG
AACATGACTAGCGGCCCGGGTGGGCCGGCGGCGGCCGCGGGCGGCAGGAAGGAGAACCACCAGTGGTATGTGTGCAACAGAGAGAAATTA
TGCGAATCACTCCAGGCTGTCTTTGTTCAGAGTTACCTTGATCAAGGAACACAGATCTTCTTAAACAACAGCATTGAGAAATCGGGCTGG
CTATTTATCCAATTATATCATTCTTTTGTGTCATCTGTTTTTAGCCTGTTTATGTCTAGAACATCTATCAATGGGTTGCTAGGAAGAGGC
TCAATGTTTGTGTTTTCACCAGATCAGTTTCAGAGACTGCTTAAAATTAATCCAGACTGGAAAACCCACAGACTTCTTGATTTAGGTGCT
GGAGATGGAGAAGTCACAAAAATCATGAGCCCTCATTTTGAAGAAATCTATGCCACTGAGCTTTCTGAAACTATGATATGGCAGCTTCAG
AAAAAGAAATACAGAGTCCTTGGTATAAATGAATGGCAGAATACGGGGTTCCAGTATGATGTCATCAGCTGCCTGAACTTGCTGGACCGC
TGTGATCAGCCCCTGACTTTGTTAAAAGATATCAGAAGTGTCTTGGAGCCAACTAGAGGCAGGGTCATCCTTGCCCTTGTCCTCCCCTTT
CATCCCTATGTGGAAAACGCACCTGTGGAATCCTCTCAAGAGGAACAGTCATTGTGTGAAGGTTCAAATTCAGCTGTTAGCATGGAACTT
TCAGAACCTATTGAAAATGGAGAGACAGAAATGTCTCCAGAAGAATCATGGGAGCACAAAGAAGAAATAAGTGAAGCAGAGCCAGGGGGT
GGTTCCTTGGGAGATGGAAGGCCGCCAGAGGAAAGTGCCCATGAAATGATGGAGGAGGAAGAGGAAATCCCAAAACCTAAGTCTGTGGTT
GCACCGCCAGGTGCTCCTAAGAAAGAGCATGTAAATGTAGTATTCATTGGGCACGTAGATGCTGGCAAGTCAACCATTGGAGGACAAATA
ATGTATTTGACTGGAATGGTTGACAAAAGGACGCTTGAAAAGTATGAAAGAGAAGCTAAAGAGAAAAACAGAGAAACTTGGTACTTGTCT
TGGGCCTTAGACACAAATCAGGAAGAACGAGACAAGGGTAAAACAGTAGAAGTGGGTCGTGCCTATTTTGAAACCGAAAAGAAGCATTTC
ACAATTCTAGATGCCCCTGGCCACAAGAGTTTTGTCCCAAATATGATTGGTGGTGCCTCTCAAGCTGATTTGGCTGTGCTGGTAATCTCA
GCCAGGAAAGGAGAGTTTGAAACTGGATTTGAAAAAGGAGGACAGACAAGAGAACATGCAATGTTGGCAAAGACAGCAGGTGTAAAACAC
CTAATTGTGCTAATTAATAAGATGGATGATCCAACAGTAAATTGGAGCAATGAGAGATATGAAGAATGTAAGGAGAAACTAGTGCCATTT
TTGAAAAAAGTTGGCTTCAATCCCAAAAAGGACATTCACTTTATGCCCTGCTCAGGACTTACTGGAGCAAATCTCAAAGAGCAGTCGGAT
TTCTGTCCTTGGTACATTGGATTACCGTTTATTCCATATCTGGATAATTTGCCGAACTTCAATAGATCAGTTGATGGACCAATCAGGCTG
CCAATTGTGGATAAGTACAAGGATATGGGCACTGTGGTCCTGGGAAAGCTGGAATCAGGATCTATTTGTAAAGGCCAGCAGCTTGTGATG
ATGCCAAACAAGCACAACGTGGAAGTTCTTGGAATACTTTCCGATGATGTAGAGACTGATACCGTAGCCCCAGGTGAAAACCTCAAAATC
AGACTGAAAGGAATTGAAGAAGAGGAGATTCTTCCAGGGTTTATACTTTGTGATCCTAATAATCTTTGTCATTCTGGACGCACATTTGAT
GCCCAGATAGTGATTATAGAGCACAAATCCATCATCTGCCCAGGCTATAATGCGGTGCTGCATATTCATACCTGTATTGAGGAGGTGGAA
ATAACAGCCTTAATCTGCTTGGTAGACAAAAAATCAGGAGAAAAAAGTAAGACCCGACCCCGTTTTGTCAAACAAGATCAAGTATGCATT
GCTCGCTTAAGGACAGCAGGAACCATCTGCCTTGAGACCTTTAAAGACTTCCCTCAGATGGGTCGTTTCACCTTAAGAGATGAGGGTAAG
ACCATTGCAATTGGAAAAGTTCTGAAACTGGTTCCAGAGAAAGACTAAGCATTTTCTTGATGACCCTGCACAATACTGTGAGGAAAATTG
ACTGCAGAAGCCTACTTCACACCGCCTTCTCTTATTTTCTGCCCATTGATAAACCTCTCCCCATATTTTGCAAAGAGGAAATTCACAGCA
AAAGTCCACATTATGTCAGCTTTCTCATATTGAGAGCTCTGCTATGCCACTGTTGAATTTTTCCCAAGATTCCTGTCCCTAGCCCTCACT
TCAAACTCTGCTTCCTTGGACAGATTTGGCAATAGCTTTGTAAGTGATGTGGACATAATTGCCTACAATAATGAAAACCTACAGGAATTT
TTTTATTTTTCATTTTCCCCTTAGGCATATTTAGTATTTTTCCCCCAGGCAGATCATTCTGAGTGTGCGAGTGTGTGTGCACATGTTACA

>53146_53146_2_METTL9-GSPT1_METTL9_chr16_21636436_ENST00000358154_GSPT1_chr16_11991892_ENST00000439887_length(amino acids)=848AA_BP=46
METGAGGSGVPRPEGKGEVPRLRAGCSSPPPAFALKGAGWARRPRWLELGRWRRWPEAAVPPPPRPGAGGDPSERPRPPMRLLAGWLCLS
LASVWLARRMWTLRSPLTRSLYVNMTSGPGGPAAAAGGRKENHQWYVCNREKLCESLQAVFVQSYLDQGTQIFLNNSIEKSGWLFIQLYH
SFVSSVFSLFMSRTSINGLLGRGSMFVFSPDQFQRLLKINPDWKTHRLLDLGAGDGEVTKIMSPHFEEIYATELSETMIWQLQKKKYRVL
GINEWQNTGFQYDVISCLNLLDRCDQPLTLLKDIRSVLEPTRGRVILALVLPFHPYVENAPVESSQEEQSLCEGSNSAVSMELSEPIENG
ETEMSPEESWEHKEEISEAEPGGGSLGDGRPPEESAHEMMEEEEEIPKPKSVVAPPGAPKKEHVNVVFIGHVDAGKSTIGGQIMYLTGMV
DKRTLEKYEREAKEKNRETWYLSWALDTNQEERDKGKTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKGEFE
TGFEKGGQTREHAMLAKTAGVKHLIVLINKMDDPTVNWSNERYEECKEKLVPFLKKVGFNPKKDIHFMPCSGLTGANLKEQSDFCPWYIG
LPFIPYLDNLPNFNRSVDGPIRLPIVDKYKDMGTVVLGKLESGSICKGQQLVMMPNKHNVEVLGILSDDVETDTVAPGENLKIRLKGIEE
EEILPGFILCDPNNLCHSGRTFDAQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALICLVDKKSGEKSKTRPRFVKQDQVCIARLRTAG

--------------------------------------------------------------
>53146_53146_3_METTL9-GSPT1_METTL9_chr16_21636436_ENST00000396014_GSPT1_chr16_11991892_ENST00000434724_length(transcript)=7480nt_BP=927nt
GGCTGCGCGCCGGCTGCTCCTCCCCACCCCCAGCCTTTGCCCTGAAGGGGGCTGGATGGGCAAGGCGGCCGCGATGGCTCGAGCTCGGGC
GGTGGCGGCGGTGGCCGGAGGCGGCGGTGCCTCCTCCTCCTCGCCCCGGCGCCGGCGGTGATCCGAGCGAGCGGCCGCGGCCCCCGATGA
GACTGCTGGCGGGCTGGCTGTGCCTGAGCCTGGCGTCCGTGTGGCTGGCGCGGAGGATGTGGACGCTGCGGAGCCCGCTCACCCGCTCCC
TGTACGTGAACATGACTAGCGGCCCGGGTGGGCCGGCGGCGGCCGCGGGCGGCAGGAAGGAGAACCACCAGTGGTATGTGTGCAACAGAG
AGAAATTATGCGAATCACTCCAGGCTGTCTTTGTTCAGAGTTACCTTGATCAAGGAACACAGATCTTCTTAAACAACAGCATTGAGAAAT
CGGGCTGGCTATTTATCCAATTATATCATTCTTTTGTGTCATCTGTTTTTAGCCTGTTTATGTCTAGAACATCTATCAATGGGTTGCTAG
GAAGAGGCTCAATGTTTGTGTTTTCACCAGATCAGTTTCAGAGACTGCTTAAAATTAATCCAGACTGGAAAACCCACAGACTTCTTGATT
TAGGTGCTGGAGATGGAGAAGTCACAAAAATCATGAGCCCTCATTTTGAAGAAATCTATGCCACTGAGCTTTCTGAAACTATGATATGGC
AGCTTCAGAAAAAGAAATACAGAGTCCTTGGTATAAATGAATGGCAGAATACGGGGTTCCAGTATGATGTCATCAGCTGCCTGAACTTGC
TGGACCGCTGTGATCAGCCCCTGACTTTGTTAAAAGATATCAGAAGTGTCTTGGAGCCAACTAGAGGCAGGGTCATCCTTGCCCTTGTCC
TCCCCTTTCATCCCTATGTGGAAAACGCACCTGTGGAATCCTCTCAAGAGGAACAGTCATTGTGTGAAGGTTCAAATTCAGCTGTTAGCA
TGGAACTTTCAGAACCTATTGTAGAAAATGGAGAGACAGAAATGTCTCCAGAAGAATCATGGGAGCACAAAGAAGAAATAAGTGAAGCAG
AGCCAGGGGGTGGTTCCTTGGGAGATGGAAGGCCGCCAGAGGAAAGTGCCCATGAAATGATGGAGGAGGAAGAGGAAATCCCAAAACCTA
AGTCTGTGGTTGCACCGCCAGGTGCTCCTAAGAAAGAGCATGTAAATGTAGTATTCATTGGGCACGTAGATGCTGGCAAGTCAACCATTG
GAGGACAAATAATGTATTTGACTGGAATGGTTGACAAAAGGACGCTTGAAAAGTATGAAAGAGAAGCTAAAGAGAAAAACAGAGAAACTT
GGTACTTGTCTTGGGCCTTAGACACAAATCAGGAAGAACGAGACAAGGGTAAAACAGTAGAAGTGGGTCGTGCCTATTTTGAAACCGAAA
AGAAGCATTTCACAATTCTAGATGCCCCTGGCCACAAGAGTTTTGTCCCAAATATGATTGGTGGTGCCTCTCAAGCTGATTTGGCTGTGC
TGGTAATCTCAGCCAGGAAAGGAGAGTTTGAAACTGGATTTGAAAAAGGAGGACAGACAAGAGAACATGCAATGTTGGCAAAGACAGCAG
GTGTAAAACACCTAATTGTGCTAATTAATAAGATGGATGATCCAACAGTAAATTGGAGCAATGAGAGATATGAAGAATGTAAGGAGAAAC
TAGTGCCATTTTTGAAAAAAGTTGGCTTCAATCCCAAAAAGGACATTCACTTTATGCCCTGCTCAGGACTTACTGGAGCAAATCTCAAAG
AGCAGTCGGATTTCTGTCCTTGGTACATTGGATTACCGTTTATTCCATATCTGGATAATTTGCCGAACTTCAATAGATCAGTTGATGGAC
CAATCAGGCTGCCAATTGTGGATAAGTACAAGGATATGGGCACTGTGGTCCTGGGAAAGCTGGAATCAGGATCTATTTGTAAAGGCCAGC
AGCTTGTGATGATGCCAAACAAGCACAACGTGGAAGTTCTTGGAATACTTTCCGATGATGTAGAGACTGATACCGTAGCCCCAGGTGAAA
ACCTCAAAATCAGACTGAAAGGAATTGAAGAAGAGGAGATTCTTCCAGGGTTTATACTTTGTGATCCTAATAATCTTTGTCATTCTGGAC
GCACATTTGATGCCCAGATAGTGATTATAGAGCACAAATCCATCATCTGCCCAGGCTATAATGCGGTGCTGCATATTCATACCTGTATTG
AGGAGGTGGAAATAACAGCCTTAATCTGCTTGGTAGACAAAAAATCAGGAGAAAAAAGTAAGACCCGACCCCGTTTTGTCAAACAAGATC
AAGTATGCATTGCTCGCTTAAGGACAGCAGGAACCATCTGCCTTGAGACCTTTAAAGACTTCCCTCAGATGGGTCGTTTCACCTTAAGAG
ATGAGGGTAAGACCATTGCAATTGGAAAAGTTCTGAAACTGGTTCCAGAGAAAGACTAAGCATTTTCTTGATGACCCTGCACAATACTGT
GAGGAAAATTGACTGCAGAAGCCTACTTCACACCGCCTTCTCTTATTTTCTGCCCATTGATAAACCTCTCCCCATATTTTGCAAAGAGGA
AATTCACAGCAAAAGTCCACATTATGTCAGCTTTCTCATATTGAGAGCTCTGCTATGCCACTGTTGAATTTTTCCCAAGATTCCTGTCCC
TAGCCCTCACTTCAAACTCTGCTTCCTTGGACAGATTTGGCAATAGCTTTGTAAGTGATGTGGACATAATTGCCTACAATAATGAAAACC
TACAGGAATTTTTTTATTTTTCATTTTCCCCTTAGGCATATTTAGTATTTTTCCCCCAGGCAGATCATTCTGAGTGTGCGAGTGTGTGTG
CACATGTTACAAAGGCAACTACCATGTTAATAAAATATTCAATTTGAAATCCTTTTCGGTATTTGAATTGCTTTTGAATAATGTTTTTTA
TCTGGATGTAACATTGTTGCATTAGCTTTTTAACTTTCCCAAGTAATTGAATACATTTTATTACTTGGACTTTTATAAACTCTTTCCCTA
CCCACTATAAATGAGACATTCACAGCGTTCAAGTTTGTATTAAAGGAAAGGATTAGTTTGACCCCTTCTTTTGATGGTTAATGCATACAT
GCAGTTAAATCCCTTTATGCAAATGTGACACTGCTTTACTAGGTCTTTTAGTTATTTATTTATTTTTTTTTTTTTTGCCAATTTATATTG
TAACATGATTTCTTGAACACAGTAAGTTGTTTTAAAATAAAAGAACAGCATACTGTAGTTTTTATAAGTAAAGCGTAATGAAATTGTACC
CCTAGAGAAAATTCCATTAACTTGTTAAATTAGTGGAATTAACAACAAATAAAGCATGTTTGAGACCTGGCAAAAATTCCTCTGGTAGTA
TTTATAAATAGAGCTGCATGCCTCTAGTATGAAAACCGTATCAGTTGCAAGTGCCACTTCTACAAGTTACTCAGTTTACTCTTTGTATCA
GTAACTTTAAAGGTTGGATGATCCTTGCTGGTTAAAGCTAAATCTCAACCTAGCAACTAAATGAAAATATTTAGAATCATCAGAATCTGA
ACAGACTAAAATTATCAGCGATAAGCAGAATCAAGCAGGGTATAAGTTTTATCTCAATTATTTGAAATTGACTGAGTTTTCTTAAGTGTA
AAGCTGAAATTTGCTAACCATGTTTTTGATGAACCACAGTGCAGCATTGTGTGGGTTTTAGATTGAATGACTCTCTGCTATAATTATCAT
GACTTTGAAATTTTTCATGAGAATAAATGAGGAATGGAGGCAATTTGTGGGTTTATCCAAAGCCCCCTTGATGTTGAGTGTTGCCATTGA
TCAAAGATAGCCTCTTTTAGATTGTGATTTCTCTCTAAATAAGATACTTTGTATATTTAATGACAAGTCTCTTCCCTATAATTTTGCTCC
TCAGAAAAGAAAAGCCTAGACAGACTGTATTTCCAGTCACAGAACATAAAACTTAATCTAATGGGTGTTTTGTTTTGTTTTGAGACAGAG
GCTCACTCTGTCACCTAGGCTGGAGTGCAGTGGCTCGATCTCAGCTCACTGCAGCCTCCACCTCCCGGATTCAAGCAATTTCCTGCCTCA
GCCTCTTGAGTAGCTGGGATTACAGGAGCCCTCCACGAGGCCCAGTTAATTTTTGTATCTTTAGTGGAGACGAGGTTTCCCCCTATTGGT
CAGGCTGGTCTCAAACTTCTGACCTCAAGTGATCCACTCGCCTCAGCCTCTCAAAAGTGCTGGGATTACAGGCATGAGGCGCCGCACTTG
GCCTAGTGTTTTCTTAACTGTGAAATTCCCATTCATTTCTTGAATGAGGCTACATCTTATGGACAGAGCAAAGTTATTGTCCTACAGATT
CTTAAAACTATAATTATGGCTATTGCATGAAATTTAAATAGATTTTATTATGTCTGCAAATCTCTGGGCTTTTATTTTTCTGGAAAATAT
AGGAGCTTTAATCAAAACATAATAGTTCTTTTTGTAATTCCATGTTAATAAAAACAAATACTAGCAATTGCTTGAATTTTAATGAATATT
TAAAAGTTCAAGAGCCACGGAAATCACTTCCAGAGATAAGAGTTCCCTTTCTAAATAGAACACATTTTTAAAAAATAAGTTATGTTTGCT
ACTAAAACATTTACACTGTTAGACTATTATGTGCATGTTGCCAAGACTCTTAAGTAACTTGGATATCAACTGTGAAGGGCCTACCTCTAA
AAAGTAACAGGTCATACAAATACAAATGTAACTGTAAAAATTCCACTGGATTCTTGCATATTTGCAAGATTAGATTATTCAAAAGAAATT
TCAGTGCTAAAATTAACCAGCAACATAAGTTCTATGGGCTTTGAAAATTGTTCTCATCTTTTTAAAGTTGATGCATTTTCAATCCTGCTT
ACACAGGCTGTTCATTTGGATAAGTAAATAAAATGTCTAAGGTGAACTTGGCATTATGTGGAGATGTTGGACCGTTATAGAGCAATACAA
ATTCCTATGCTGTCATTCTGTTTTCTGCAAATGCAAACGTGCTTATATGGTCAACAGTGCAAAAATAGGGTAGTTGGCTGCATATTTAGG
GTATTACCTAAGCATTTGTTCTCTAACGTTGCTCTACTAGAATGATTTTTTTCTTGCATCTTTTCACATTAATGATGTTCTTTATATAAC
TTTCATGCGATTATTTAGTTTTTTAAATTAATAAAGTGAATTTAAGAAATATTGAAATAAACATCTAAGTAATTGCCATTTTAAACCCTT
GTTTCTTACTGTGGGAGAGGGGGAAATACAGCACTCATTTCTTGTTTTTAATTTGCAGAAGTAAGTGAAAATCTATGTAAAATCAAACCA
AAAGAGTTGGACTGAGTGTGTATTGTCTTGAGATTAAGTGACAAATAGTAAAGTGTTACTGAGTAATTAAGCCCATGTATTTTTTTTTTG
TGAGTTGAAAATCTTTGAAATATGTGATAACCGAATGTCAAAAGTTCCTAAACTCTAACAGTGCAGGTTGTTCACTGTAACGAGGTAACT
CATATTTGCTGGTTACATAAACTACAAGTACTGCTCTCACAATATGGGACTTTGAACTGTGATGTAGTTCAACAGTTGCCGGCATCCTCT
CAGCTGATACGCTGCGAATATTTTGGGTTAGACTTGCAGCCAGATGCAGTTTTGCAACCCAAGAAAAAAGTTGAACCTATGATCAAAAAC
TGCTCCCAAGATGAACCTGGAAAAAAATCAGCTAAGCTCCCTTGGCGATCTGCAGGAACACTAGTAATGACTGGAATTACTCCGTGATCT
TTGATGACTATTACACATAACAGCACTCTAGCACCTTTTCTTACTGGCATGGACTTCCTCATGGACTGCTACTTCATGGATGATAGCTTC
ATTGCTTTGGGTAGGGATTTAAGGTAGTCAAGGGGAAAATACGCAGTTTTATTACAGGTCTTAACATCAGGCAACTTTCAACTTTAAAAC
CCTTTGTGAAAAATGTGGTTATAGCACTATAGCTCTGATTTTAGGATGGTTAAATGTTATATTCATTGTTGGCTTACCTTATCAAACTGT
GCCATTAATCCTTTCACAGACATAGGTAAGGAAGAGAACAACCAGTGGATTCAGGGGACAATTATCTATCTCCAAATAATAGGCTTTTAT
TTCTTGCAGCTAACTTTTTCAGTGATTCTAGCAGATGCCATCTAGTACATCCTTGATCTTGTTTCTTTCGTGAGAGATCTCGCCATGGCA
GCATCTTGTTAAGTAAGTGTAATTGCACATGCACAAAAGACTTAACTAGCTTTACATTTAGCAGTCAGTTGGTTAGATTAGGTTTCATAG
TAAATGAATAGGAATAGAAAGAATAGGAAGTGTTTTTATTTTCCAGTAGTAATTCCGTGGATTCCATTTGACCCAGTTTACTATCAGTTC
AGTTCAGGTAGATTTGGTTCAACTTTTGGTGGTTTTTGGCTCTAGGATATTCTTGACTTTAATATCCTAGAACTTACTGAGTCTTCCCTT
CAATAAATACACTTCTCACATACCTCTAATCCTATGCTTCCTTGAAACAATAATGCTAGCTGAGTTGTTTACTAAGGATTATTATAAGGG
CCTGAAGGTGTGGGAGTGGAGATTAATTAAAACCTTTATGTTCTCCAATATAAGGGAAAAGCAGGTTGGTACTACTTCTGATTAGGCAGA
AAACACCAGGATTCCTTAAGTGATCCTTGAAATGGTTATTGTTTTCTGCCTTGTCACATTTGCCACTGTGCCCTTTAAAACGATGTGGAA
ACCTCAGGTTTGTGGACAGCACAGGTGGAATGACATCTTGTGCTTCCTGAGGCTCCCCTCTACCAGGCACATTAGCTTAGTGCTTCAGAT
GTCAGCCCAAGTCCTTGTTACCTCCTTTTCCTGCTGCCCAGGGAAGAGTGTGTGTGCTGGAGCTGGAGCGCTTGCACTCTTCAGGTGACT
ATTCTCACCTCCATTTCCTCCACATGCATTAGGTGAAACTGAGGTCTAAGCCTCCTGCAAGGTCTACATTTTAAGGACTCACACATCAGG
CTCTCAGAAATGTACACAGGTATTAGTTCTGTTTGTTCTAAAGGAAATGTGGGTATCTCTCAGGCCAGGACTTAGTGACTAGTTTTCGCT
AGACAGCAGGTTAATACCTAGATCTCATTTAAAAAAAAAAAAAAAAAACAGGATTAAAGGGAACTGATCAGGTTTGTTGAGTTTTTTAGC
CTAATTCCAAAGCATGGAAGAGTGCTCTAGGTAGGAAAGAAAGCTTTTTCTTACGATTTGTAGCTACCTACTGTGCCTGACTTGGTGCCT
GTGTGAGGATTAAGCCCTTAGTCTGCTCTTGCAATTATTCAAATGACAAATTAAATTTGCTTTTGTAATAACAATAAAAGTTGTCATCTT

>53146_53146_3_METTL9-GSPT1_METTL9_chr16_21636436_ENST00000396014_GSPT1_chr16_11991892_ENST00000434724_length(amino acids)=828AA_BP=25
LRAGCSSPPPAFALKGAGWARRPRWLELGRWRRWPEAAVPPPPRPGAGGDPSERPRPPMRLLAGWLCLSLASVWLARRMWTLRSPLTRSL
YVNMTSGPGGPAAAAGGRKENHQWYVCNREKLCESLQAVFVQSYLDQGTQIFLNNSIEKSGWLFIQLYHSFVSSVFSLFMSRTSINGLLG
RGSMFVFSPDQFQRLLKINPDWKTHRLLDLGAGDGEVTKIMSPHFEEIYATELSETMIWQLQKKKYRVLGINEWQNTGFQYDVISCLNLL
DRCDQPLTLLKDIRSVLEPTRGRVILALVLPFHPYVENAPVESSQEEQSLCEGSNSAVSMELSEPIVENGETEMSPEESWEHKEEISEAE
PGGGSLGDGRPPEESAHEMMEEEEEIPKPKSVVAPPGAPKKEHVNVVFIGHVDAGKSTIGGQIMYLTGMVDKRTLEKYEREAKEKNRETW
YLSWALDTNQEERDKGKTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKGEFETGFEKGGQTREHAMLAKTAG
VKHLIVLINKMDDPTVNWSNERYEECKEKLVPFLKKVGFNPKKDIHFMPCSGLTGANLKEQSDFCPWYIGLPFIPYLDNLPNFNRSVDGP
IRLPIVDKYKDMGTVVLGKLESGSICKGQQLVMMPNKHNVEVLGILSDDVETDTVAPGENLKIRLKGIEEEEILPGFILCDPNNLCHSGR
TFDAQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALICLVDKKSGEKSKTRPRFVKQDQVCIARLRTAGTICLETFKDFPQMGRFTLRD

--------------------------------------------------------------
>53146_53146_4_METTL9-GSPT1_METTL9_chr16_21636436_ENST00000396014_GSPT1_chr16_11991892_ENST00000439887_length(transcript)=2926nt_BP=927nt
GGCTGCGCGCCGGCTGCTCCTCCCCACCCCCAGCCTTTGCCCTGAAGGGGGCTGGATGGGCAAGGCGGCCGCGATGGCTCGAGCTCGGGC
GGTGGCGGCGGTGGCCGGAGGCGGCGGTGCCTCCTCCTCCTCGCCCCGGCGCCGGCGGTGATCCGAGCGAGCGGCCGCGGCCCCCGATGA
GACTGCTGGCGGGCTGGCTGTGCCTGAGCCTGGCGTCCGTGTGGCTGGCGCGGAGGATGTGGACGCTGCGGAGCCCGCTCACCCGCTCCC
TGTACGTGAACATGACTAGCGGCCCGGGTGGGCCGGCGGCGGCCGCGGGCGGCAGGAAGGAGAACCACCAGTGGTATGTGTGCAACAGAG
AGAAATTATGCGAATCACTCCAGGCTGTCTTTGTTCAGAGTTACCTTGATCAAGGAACACAGATCTTCTTAAACAACAGCATTGAGAAAT
CGGGCTGGCTATTTATCCAATTATATCATTCTTTTGTGTCATCTGTTTTTAGCCTGTTTATGTCTAGAACATCTATCAATGGGTTGCTAG
GAAGAGGCTCAATGTTTGTGTTTTCACCAGATCAGTTTCAGAGACTGCTTAAAATTAATCCAGACTGGAAAACCCACAGACTTCTTGATT
TAGGTGCTGGAGATGGAGAAGTCACAAAAATCATGAGCCCTCATTTTGAAGAAATCTATGCCACTGAGCTTTCTGAAACTATGATATGGC
AGCTTCAGAAAAAGAAATACAGAGTCCTTGGTATAAATGAATGGCAGAATACGGGGTTCCAGTATGATGTCATCAGCTGCCTGAACTTGC
TGGACCGCTGTGATCAGCCCCTGACTTTGTTAAAAGATATCAGAAGTGTCTTGGAGCCAACTAGAGGCAGGGTCATCCTTGCCCTTGTCC
TCCCCTTTCATCCCTATGTGGAAAACGCACCTGTGGAATCCTCTCAAGAGGAACAGTCATTGTGTGAAGGTTCAAATTCAGCTGTTAGCA
TGGAACTTTCAGAACCTATTGAAAATGGAGAGACAGAAATGTCTCCAGAAGAATCATGGGAGCACAAAGAAGAAATAAGTGAAGCAGAGC
CAGGGGGTGGTTCCTTGGGAGATGGAAGGCCGCCAGAGGAAAGTGCCCATGAAATGATGGAGGAGGAAGAGGAAATCCCAAAACCTAAGT
CTGTGGTTGCACCGCCAGGTGCTCCTAAGAAAGAGCATGTAAATGTAGTATTCATTGGGCACGTAGATGCTGGCAAGTCAACCATTGGAG
GACAAATAATGTATTTGACTGGAATGGTTGACAAAAGGACGCTTGAAAAGTATGAAAGAGAAGCTAAAGAGAAAAACAGAGAAACTTGGT
ACTTGTCTTGGGCCTTAGACACAAATCAGGAAGAACGAGACAAGGGTAAAACAGTAGAAGTGGGTCGTGCCTATTTTGAAACCGAAAAGA
AGCATTTCACAATTCTAGATGCCCCTGGCCACAAGAGTTTTGTCCCAAATATGATTGGTGGTGCCTCTCAAGCTGATTTGGCTGTGCTGG
TAATCTCAGCCAGGAAAGGAGAGTTTGAAACTGGATTTGAAAAAGGAGGACAGACAAGAGAACATGCAATGTTGGCAAAGACAGCAGGTG
TAAAACACCTAATTGTGCTAATTAATAAGATGGATGATCCAACAGTAAATTGGAGCAATGAGAGATATGAAGAATGTAAGGAGAAACTAG
TGCCATTTTTGAAAAAAGTTGGCTTCAATCCCAAAAAGGACATTCACTTTATGCCCTGCTCAGGACTTACTGGAGCAAATCTCAAAGAGC
AGTCGGATTTCTGTCCTTGGTACATTGGATTACCGTTTATTCCATATCTGGATAATTTGCCGAACTTCAATAGATCAGTTGATGGACCAA
TCAGGCTGCCAATTGTGGATAAGTACAAGGATATGGGCACTGTGGTCCTGGGAAAGCTGGAATCAGGATCTATTTGTAAAGGCCAGCAGC
TTGTGATGATGCCAAACAAGCACAACGTGGAAGTTCTTGGAATACTTTCCGATGATGTAGAGACTGATACCGTAGCCCCAGGTGAAAACC
TCAAAATCAGACTGAAAGGAATTGAAGAAGAGGAGATTCTTCCAGGGTTTATACTTTGTGATCCTAATAATCTTTGTCATTCTGGACGCA
CATTTGATGCCCAGATAGTGATTATAGAGCACAAATCCATCATCTGCCCAGGCTATAATGCGGTGCTGCATATTCATACCTGTATTGAGG
AGGTGGAAATAACAGCCTTAATCTGCTTGGTAGACAAAAAATCAGGAGAAAAAAGTAAGACCCGACCCCGTTTTGTCAAACAAGATCAAG
TATGCATTGCTCGCTTAAGGACAGCAGGAACCATCTGCCTTGAGACCTTTAAAGACTTCCCTCAGATGGGTCGTTTCACCTTAAGAGATG
AGGGTAAGACCATTGCAATTGGAAAAGTTCTGAAACTGGTTCCAGAGAAAGACTAAGCATTTTCTTGATGACCCTGCACAATACTGTGAG
GAAAATTGACTGCAGAAGCCTACTTCACACCGCCTTCTCTTATTTTCTGCCCATTGATAAACCTCTCCCCATATTTTGCAAAGAGGAAAT
TCACAGCAAAAGTCCACATTATGTCAGCTTTCTCATATTGAGAGCTCTGCTATGCCACTGTTGAATTTTTCCCAAGATTCCTGTCCCTAG
CCCTCACTTCAAACTCTGCTTCCTTGGACAGATTTGGCAATAGCTTTGTAAGTGATGTGGACATAATTGCCTACAATAATGAAAACCTAC
AGGAATTTTTTTATTTTTCATTTTCCCCTTAGGCATATTTAGTATTTTTCCCCCAGGCAGATCATTCTGAGTGTGCGAGTGTGTGTGCAC

>53146_53146_4_METTL9-GSPT1_METTL9_chr16_21636436_ENST00000396014_GSPT1_chr16_11991892_ENST00000439887_length(amino acids)=827AA_BP=25
LRAGCSSPPPAFALKGAGWARRPRWLELGRWRRWPEAAVPPPPRPGAGGDPSERPRPPMRLLAGWLCLSLASVWLARRMWTLRSPLTRSL
YVNMTSGPGGPAAAAGGRKENHQWYVCNREKLCESLQAVFVQSYLDQGTQIFLNNSIEKSGWLFIQLYHSFVSSVFSLFMSRTSINGLLG
RGSMFVFSPDQFQRLLKINPDWKTHRLLDLGAGDGEVTKIMSPHFEEIYATELSETMIWQLQKKKYRVLGINEWQNTGFQYDVISCLNLL
DRCDQPLTLLKDIRSVLEPTRGRVILALVLPFHPYVENAPVESSQEEQSLCEGSNSAVSMELSEPIENGETEMSPEESWEHKEEISEAEP
GGGSLGDGRPPEESAHEMMEEEEEIPKPKSVVAPPGAPKKEHVNVVFIGHVDAGKSTIGGQIMYLTGMVDKRTLEKYEREAKEKNRETWY
LSWALDTNQEERDKGKTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKGEFETGFEKGGQTREHAMLAKTAGV
KHLIVLINKMDDPTVNWSNERYEECKEKLVPFLKKVGFNPKKDIHFMPCSGLTGANLKEQSDFCPWYIGLPFIPYLDNLPNFNRSVDGPI
RLPIVDKYKDMGTVVLGKLESGSICKGQQLVMMPNKHNVEVLGILSDDVETDTVAPGENLKIRLKGIEEEEILPGFILCDPNNLCHSGRT
FDAQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALICLVDKKSGEKSKTRPRFVKQDQVCIARLRTAGTICLETFKDFPQMGRFTLRDE

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Fusion Gene PPI Analysis for METTL9-GSPT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for METTL9-GSPT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for METTL9-GSPT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource