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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MFSD11-ASF1B (FusionGDB2 ID:53229)

Fusion Gene Summary for MFSD11-ASF1B

check button Fusion gene summary
Fusion gene informationFusion gene name: MFSD11-ASF1B
Fusion gene ID: 53229
HgeneTgene
Gene symbol

MFSD11

ASF1B

Gene ID

79157

55723

Gene namemajor facilitator superfamily domain containing 11anti-silencing function 1B histone chaperone
SynonymsETCIA-II
Cytomap

17q25.1-q25.2

19p13.12

Type of geneprotein-codingprotein-coding
DescriptionUNC93-like protein MFSD11major facilitator superfamily domain-containing protein 11protein EThistone chaperone ASF1BASF1 anti-silencing function 1 homolog BCCG1-interacting factor A-IIanti-silencing function protein 1 homolog BhAsf1hAsf1bhCIA-II
Modification date2020031320200313
UniProtAcc

O43934

Q9NVP2

Ensembl transtripts involved in fusion geneENST00000590070, ENST00000336509, 
ENST00000355954, ENST00000586622, 
ENST00000588460, ENST00000590514, 
ENST00000593181, ENST00000590393, 
ENST00000591864, 		ENST00000263382, 
ENST00000474890, ENST00000592798, 
Fusion gene scores* DoF score10 X 10 X 7=7007 X 5 X 6=210
# samples 108
** MAII scorelog2(10/700*10)=-2.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MFSD11 [Title/Abstract] AND ASF1B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMFSD11(74772623)-ASF1B(14237049), # samples:1
Anticipated loss of major functional domain due to fusion event.MFSD11-ASF1B seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneASF1B

GO:0006335

DNA replication-dependent nucleosome assembly

14718166

TgeneASF1B

GO:0006336

DNA replication-independent nucleosome assembly

14718166


check buttonFusion gene breakpoints across MFSD11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ASF1B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-61-2095MFSD11chr17

74772623

+ASF1Bchr19

14237049

-


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Fusion Gene ORF analysis for MFSD11-ASF1B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000590070ENST00000263382MFSD11chr17

74772623

+ASF1Bchr19

14237049

-
3UTR-3CDSENST00000590070ENST00000474890MFSD11chr17

74772623

+ASF1Bchr19

14237049

-
3UTR-3CDSENST00000590070ENST00000592798MFSD11chr17

74772623

+ASF1Bchr19

14237049

-
Frame-shiftENST00000336509ENST00000263382MFSD11chr17

74772623

+ASF1Bchr19

14237049

-
Frame-shiftENST00000336509ENST00000474890MFSD11chr17

74772623

+ASF1Bchr19

14237049

-
Frame-shiftENST00000336509ENST00000592798MFSD11chr17

74772623

+ASF1Bchr19

14237049

-
Frame-shiftENST00000355954ENST00000263382MFSD11chr17

74772623

+ASF1Bchr19

14237049

-
Frame-shiftENST00000355954ENST00000474890MFSD11chr17

74772623

+ASF1Bchr19

14237049

-
Frame-shiftENST00000355954ENST00000592798MFSD11chr17

74772623

+ASF1Bchr19

14237049

-
Frame-shiftENST00000586622ENST00000263382MFSD11chr17

74772623

+ASF1Bchr19

14237049

-
Frame-shiftENST00000586622ENST00000474890MFSD11chr17

74772623

+ASF1Bchr19

14237049

-
Frame-shiftENST00000586622ENST00000592798MFSD11chr17

74772623

+ASF1Bchr19

14237049

-
Frame-shiftENST00000588460ENST00000263382MFSD11chr17

74772623

+ASF1Bchr19

14237049

-
Frame-shiftENST00000588460ENST00000474890MFSD11chr17

74772623

+ASF1Bchr19

14237049

-
Frame-shiftENST00000588460ENST00000592798MFSD11chr17

74772623

+ASF1Bchr19

14237049

-
Frame-shiftENST00000590514ENST00000263382MFSD11chr17

74772623

+ASF1Bchr19

14237049

-
Frame-shiftENST00000590514ENST00000474890MFSD11chr17

74772623

+ASF1Bchr19

14237049

-
Frame-shiftENST00000590514ENST00000592798MFSD11chr17

74772623

+ASF1Bchr19

14237049

-
Frame-shiftENST00000593181ENST00000263382MFSD11chr17

74772623

+ASF1Bchr19

14237049

-
Frame-shiftENST00000593181ENST00000474890MFSD11chr17

74772623

+ASF1Bchr19

14237049

-
Frame-shiftENST00000593181ENST00000592798MFSD11chr17

74772623

+ASF1Bchr19

14237049

-
intron-3CDSENST00000590393ENST00000263382MFSD11chr17

74772623

+ASF1Bchr19

14237049

-
intron-3CDSENST00000590393ENST00000474890MFSD11chr17

74772623

+ASF1Bchr19

14237049

-
intron-3CDSENST00000590393ENST00000592798MFSD11chr17

74772623

+ASF1Bchr19

14237049

-
intron-3CDSENST00000591864ENST00000263382MFSD11chr17

74772623

+ASF1Bchr19

14237049

-
intron-3CDSENST00000591864ENST00000474890MFSD11chr17

74772623

+ASF1Bchr19

14237049

-
intron-3CDSENST00000591864ENST00000592798MFSD11chr17

74772623

+ASF1Bchr19

14237049

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MFSD11-ASF1B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MFSD11-ASF1B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:74772623/:14237049)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MFSD11

O43934

ASF1B

Q9NVP2

FUNCTION: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA. Required for spermatogenesis. {ECO:0000269|PubMed:11897662, ECO:0000269|PubMed:12842904, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15664198, ECO:0000269|PubMed:16151251}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MFSD11-ASF1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MFSD11-ASF1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MFSD11-ASF1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MFSD11-ASF1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource