FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:MFSD8-HIPK2 (FusionGDB2 ID:53289)

Fusion Gene Summary for MFSD8-HIPK2

check button Fusion gene summary
Fusion gene informationFusion gene name: MFSD8-HIPK2
Fusion gene ID: 53289
HgeneTgene
Gene symbol

MFSD8

HIPK2

Gene ID

256471

28996

Gene namemajor facilitator superfamily domain containing 8homeodomain interacting protein kinase 2
SynonymsCCMD|CLN7PRO0593
Cytomap

4q28.2

7q34

Type of geneprotein-codingprotein-coding
Descriptionmajor facilitator superfamily domain-containing protein 8ceroid-lipofuscinosis, neuronal 7, late infantilehomeodomain-interacting protein kinase 2hHIPk2
Modification date2020032920200313
UniProtAcc

Q8NHS3

Q9H2X6

Ensembl transtripts involved in fusion geneENST00000515130, ENST00000513559, 
ENST00000541133, ENST00000296468, 
ENST00000342645, ENST00000406875, 
ENST00000428878, 
Fusion gene scores* DoF score1 X 2 X 1=28 X 8 X 3=192
# samples 29
** MAII scorelog2(2/2*10)=3.32192809488736log2(9/192*10)=-1.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MFSD8 [Title/Abstract] AND HIPK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMFSD8(128870959)-HIPK2(139305309), # samples:2
Anticipated loss of major functional domain due to fusion event.MFSD8-HIPK2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
MFSD8-HIPK2 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
MFSD8-HIPK2 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHIPK2

GO:0006468

protein phosphorylation

19448668

TgeneHIPK2

GO:0006978

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

14647468

TgeneHIPK2

GO:0045766

positive regulation of angiogenesis

19046997

TgeneHIPK2

GO:0060395

SMAD protein signal transduction

12874272


check buttonFusion gene breakpoints across MFSD8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HIPK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-7704-01AMFSD8chr4

128870959

-HIPK2chr7

139305309

-
ChimerDB4STADTCGA-BR-7704MFSD8chr4

128870958

-HIPK2chr7

139305309

-


Top

Fusion Gene ORF analysis for MFSD8-HIPK2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000515130ENST00000342645MFSD8chr4

128870959

-HIPK2chr7

139305309

-
5UTR-3CDSENST00000515130ENST00000342645MFSD8chr4

128870958

-HIPK2chr7

139305309

-
5UTR-3CDSENST00000515130ENST00000406875MFSD8chr4

128870959

-HIPK2chr7

139305309

-
5UTR-3CDSENST00000515130ENST00000406875MFSD8chr4

128870958

-HIPK2chr7

139305309

-
5UTR-3CDSENST00000515130ENST00000428878MFSD8chr4

128870959

-HIPK2chr7

139305309

-
5UTR-3CDSENST00000515130ENST00000428878MFSD8chr4

128870958

-HIPK2chr7

139305309

-
Frame-shiftENST00000513559ENST00000342645MFSD8chr4

128870959

-HIPK2chr7

139305309

-
Frame-shiftENST00000513559ENST00000342645MFSD8chr4

128870958

-HIPK2chr7

139305309

-
Frame-shiftENST00000513559ENST00000406875MFSD8chr4

128870959

-HIPK2chr7

139305309

-
Frame-shiftENST00000513559ENST00000406875MFSD8chr4

128870958

-HIPK2chr7

139305309

-
Frame-shiftENST00000513559ENST00000428878MFSD8chr4

128870959

-HIPK2chr7

139305309

-
Frame-shiftENST00000513559ENST00000428878MFSD8chr4

128870958

-HIPK2chr7

139305309

-
Frame-shiftENST00000541133ENST00000342645MFSD8chr4

128870959

-HIPK2chr7

139305309

-
Frame-shiftENST00000541133ENST00000342645MFSD8chr4

128870958

-HIPK2chr7

139305309

-
Frame-shiftENST00000541133ENST00000406875MFSD8chr4

128870959

-HIPK2chr7

139305309

-
Frame-shiftENST00000541133ENST00000406875MFSD8chr4

128870958

-HIPK2chr7

139305309

-
Frame-shiftENST00000541133ENST00000428878MFSD8chr4

128870959

-HIPK2chr7

139305309

-
Frame-shiftENST00000541133ENST00000428878MFSD8chr4

128870958

-HIPK2chr7

139305309

-
In-frameENST00000296468ENST00000342645MFSD8chr4

128870959

-HIPK2chr7

139305309

-
In-frameENST00000296468ENST00000342645MFSD8chr4

128870958

-HIPK2chr7

139305309

-
In-frameENST00000296468ENST00000406875MFSD8chr4

128870959

-HIPK2chr7

139305309

-
In-frameENST00000296468ENST00000406875MFSD8chr4

128870958

-HIPK2chr7

139305309

-
In-frameENST00000296468ENST00000428878MFSD8chr4

128870959

-HIPK2chr7

139305309

-
In-frameENST00000296468ENST00000428878MFSD8chr4

128870958

-HIPK2chr7

139305309

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000296468MFSD8chr4128870959-ENST00000406875HIPK2chr7139305309-136613263482303651
ENST00000296468MFSD8chr4128870959-ENST00000428878HIPK2chr7139305309-25213263482222624
ENST00000296468MFSD8chr4128870959-ENST00000342645HIPK2chr7139305309-14643263481463371
ENST00000296468MFSD8chr4128870958-ENST00000406875HIPK2chr7139305309-136613263482303651
ENST00000296468MFSD8chr4128870958-ENST00000428878HIPK2chr7139305309-25213263482222624
ENST00000296468MFSD8chr4128870958-ENST00000342645HIPK2chr7139305309-14643263481463371

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000296468ENST00000406875MFSD8chr4128870959-HIPK2chr7139305309-0.0044469480.9955531
ENST00000296468ENST00000428878MFSD8chr4128870959-HIPK2chr7139305309-0.03832510.96167487
ENST00000296468ENST00000342645MFSD8chr4128870959-HIPK2chr7139305309-0.0067798550.9932201
ENST00000296468ENST00000406875MFSD8chr4128870958-HIPK2chr7139305309-0.0044469480.9955531
ENST00000296468ENST00000428878MFSD8chr4128870958-HIPK2chr7139305309-0.03832510.96167487
ENST00000296468ENST00000342645MFSD8chr4128870958-HIPK2chr7139305309-0.0067798550.9932201

Top

Fusion Genomic Features for MFSD8-HIPK2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for MFSD8-HIPK2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:128870959/chr7:139305309)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MFSD8

Q8NHS3

HIPK2

Q9H2X6

FUNCTION: May be a carrier that transport small solutes by using chemiosmotic ion gradients. {ECO:0000305}.FUNCTION: Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1 and ZBTB4. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. Activates CREB1 and ATF1 transcription factors by phosphorylation in response to genotoxic stress. In response to DNA damage, stabilizes PML by phosphorylation. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Promotes angiogenesis, and is involved in erythroid differentiation, especially during fetal liver erythropoiesis. Phosphorylation of RUNX1 and EP300 stimulates EP300 transcription regulation activity. Triggers ZBTB4 protein degradation in response to DNA damage. Modulates HMGA1 DNA-binding affinity. In response to high glucose, triggers phosphorylation-mediated subnuclear localization shifting of PDX1. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. {ECO:0000269|PubMed:11740489, ECO:0000269|PubMed:11925430, ECO:0000269|PubMed:12851404, ECO:0000269|PubMed:12874272, ECO:0000269|PubMed:14678985, ECO:0000269|PubMed:17018294, ECO:0000269|PubMed:17960875, ECO:0000269|PubMed:18695000, ECO:0000269|PubMed:18809579, ECO:0000269|PubMed:19015637, ECO:0000269|PubMed:19046997, ECO:0000269|PubMed:19448668, ECO:0000269|PubMed:20307497, ECO:0000269|PubMed:20573984, ECO:0000269|PubMed:20637728, ECO:0000269|PubMed:20980392, ECO:0000269|PubMed:21192925, ECO:0000269|PubMed:22825850}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-41313_1466519.0MotifNote=Dileucine internalization motif
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-41313_1466519.0MotifNote=Dileucine internalization motif
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-4131_4066519.0Topological domainCytoplasmic
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-4131_4066519.0Topological domainCytoplasmic
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-41341_6166519.0TransmembraneHelical
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-41341_6166519.0TransmembraneHelical
TgeneHIPK2chr4:128870958chr7:139305309ENST000004068755151088_10945391199.0Compositional biasNote=Poly-Ala
TgeneHIPK2chr4:128870958chr7:139305309ENST000004288785151088_10945391172.0Compositional biasNote=Poly-Ala
TgeneHIPK2chr4:128870959chr7:139305309ENST000004068755151088_10945391199.0Compositional biasNote=Poly-Ala
TgeneHIPK2chr4:128870959chr7:139305309ENST000004288785151088_10945391172.0Compositional biasNote=Poly-Ala
TgeneHIPK2chr4:128870958chr7:139305309ENST00000406875515802_8055391199.0MotifNote=Nuclear localization signal 1 (NLS1)
TgeneHIPK2chr4:128870958chr7:139305309ENST00000406875515832_8355391199.0MotifNote=Nuclear localization signal 2 (NLS2)
TgeneHIPK2chr4:128870958chr7:139305309ENST00000428878515802_8055391172.0MotifNote=Nuclear localization signal 1 (NLS1)
TgeneHIPK2chr4:128870958chr7:139305309ENST00000428878515832_8355391172.0MotifNote=Nuclear localization signal 2 (NLS2)
TgeneHIPK2chr4:128870959chr7:139305309ENST00000406875515802_8055391199.0MotifNote=Nuclear localization signal 1 (NLS1)
TgeneHIPK2chr4:128870959chr7:139305309ENST00000406875515832_8355391199.0MotifNote=Nuclear localization signal 2 (NLS2)
TgeneHIPK2chr4:128870959chr7:139305309ENST00000428878515802_8055391172.0MotifNote=Nuclear localization signal 1 (NLS1)
TgeneHIPK2chr4:128870959chr7:139305309ENST00000428878515832_8355391172.0MotifNote=Nuclear localization signal 2 (NLS2)
TgeneHIPK2chr4:128870958chr7:139305309ENST00000406875515873_9805391199.0RegionRequired for localization to nuclear speckles
TgeneHIPK2chr4:128870958chr7:139305309ENST00000406875515984_11985391199.0RegionNote=Autoinhibitory domain (AID)
TgeneHIPK2chr4:128870958chr7:139305309ENST00000428878515873_9805391172.0RegionRequired for localization to nuclear speckles
TgeneHIPK2chr4:128870958chr7:139305309ENST00000428878515984_11985391172.0RegionNote=Autoinhibitory domain (AID)
TgeneHIPK2chr4:128870959chr7:139305309ENST00000406875515873_9805391199.0RegionRequired for localization to nuclear speckles
TgeneHIPK2chr4:128870959chr7:139305309ENST00000406875515984_11985391199.0RegionNote=Autoinhibitory domain (AID)
TgeneHIPK2chr4:128870959chr7:139305309ENST00000428878515873_9805391172.0RegionRequired for localization to nuclear speckles
TgeneHIPK2chr4:128870959chr7:139305309ENST00000428878515984_11985391172.0RegionNote=Autoinhibitory domain (AID)

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-413127_13166519.0Topological domainExtracellular
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-413153_17366519.0Topological domainCytoplasmic
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-413195_21166519.0Topological domainExtracellular
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-413233_26666519.0Topological domainCytoplasmic
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-413288_30466519.0Topological domainExtracellular
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-413326_33766519.0Topological domainCytoplasmic
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-413359_41266519.0Topological domainExtracellular
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-413434_45166519.0Topological domainCytoplasmic
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-413473_48266519.0Topological domainExtracellular
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-413504_51866519.0Topological domainCytoplasmic
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-41362_7466519.0Topological domainExtracellular
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-41396_10566519.0Topological domainCytoplasmic
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-413127_13166519.0Topological domainExtracellular
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-413153_17366519.0Topological domainCytoplasmic
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-413195_21166519.0Topological domainExtracellular
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-413233_26666519.0Topological domainCytoplasmic
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-413288_30466519.0Topological domainExtracellular
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-413326_33766519.0Topological domainCytoplasmic
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-413359_41266519.0Topological domainExtracellular
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-413434_45166519.0Topological domainCytoplasmic
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-413473_48266519.0Topological domainExtracellular
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-413504_51866519.0Topological domainCytoplasmic
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-41362_7466519.0Topological domainExtracellular
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-41396_10566519.0Topological domainCytoplasmic
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-413106_12666519.0TransmembraneHelical
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-413132_15266519.0TransmembraneHelical
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-413174_19466519.0TransmembraneHelical
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-413212_23266519.0TransmembraneHelical
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-413267_28766519.0TransmembraneHelical
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-413305_32566519.0TransmembraneHelical
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-413338_35866519.0TransmembraneHelical
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-413413_43366519.0TransmembraneHelical
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-413452_47266519.0TransmembraneHelical
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-413483_50366519.0TransmembraneHelical
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-41375_9566519.0TransmembraneHelical
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-413106_12666519.0TransmembraneHelical
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-413132_15266519.0TransmembraneHelical
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-413174_19466519.0TransmembraneHelical
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-413212_23266519.0TransmembraneHelical
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-413267_28766519.0TransmembraneHelical
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-413305_32566519.0TransmembraneHelical
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-413338_35866519.0TransmembraneHelical
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-413413_43366519.0TransmembraneHelical
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-413452_47266519.0TransmembraneHelical
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-413483_50366519.0TransmembraneHelical
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-41375_9566519.0TransmembraneHelical
TgeneHIPK2chr4:128870958chr7:139305309ENST00000406875515199_5275391199.0DomainProtein kinase
TgeneHIPK2chr4:128870958chr7:139305309ENST00000428878515199_5275391172.0DomainProtein kinase
TgeneHIPK2chr4:128870959chr7:139305309ENST00000406875515199_5275391199.0DomainProtein kinase
TgeneHIPK2chr4:128870959chr7:139305309ENST00000428878515199_5275391172.0DomainProtein kinase
TgeneHIPK2chr4:128870958chr7:139305309ENST00000406875515205_2135391199.0Nucleotide bindingATP
TgeneHIPK2chr4:128870958chr7:139305309ENST00000428878515205_2135391172.0Nucleotide bindingATP
TgeneHIPK2chr4:128870959chr7:139305309ENST00000406875515205_2135391199.0Nucleotide bindingATP
TgeneHIPK2chr4:128870959chr7:139305309ENST00000428878515205_2135391172.0Nucleotide bindingATP
TgeneHIPK2chr4:128870958chr7:139305309ENST0000040687551597_2305391199.0RegionTranscriptional corepression
TgeneHIPK2chr4:128870958chr7:139305309ENST0000042887851597_2305391172.0RegionTranscriptional corepression
TgeneHIPK2chr4:128870959chr7:139305309ENST0000040687551597_2305391199.0RegionTranscriptional corepression
TgeneHIPK2chr4:128870959chr7:139305309ENST0000042887851597_2305391172.0RegionTranscriptional corepression


Top

Fusion Gene Sequence for MFSD8-HIPK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>53289_53289_1_MFSD8-HIPK2_MFSD8_chr4_128870958_ENST00000296468_HIPK2_chr7_139305309_ENST00000342645_length(transcript)=1464nt_BP=326nt
AGGTTACAAGCAGCAGATCCCACCTTCAGTCCTGGCTCTGACAAGCCCTCCAGCTTCACGCCACCCGGGATGGGAGAAAGCAGGTGTCGC
GAGAGTTGGGCGCAAGACGCCTTGTAGGGAGTGTAACTATGGCCGGCCTGCGGAACGAAAGTGAACAGGAGCCGCTCTTAGGCGACACAC
CTGGAAGCAGAGAATGGGACATTTTAGAGACTGAAGAGCATTATAAGAGCCGATGGAGATCTATTAGGATTTTATATCTTACTATGTTTC
TCAGCAGTGTAGGGTTTTCTGTAGTGATGATGTCCATATGGCCATATCTCCAAAAGCGTCAAATCATGTTTCCAGAACATGGAGATCTGC
AAGCGTCGGGTGAATATGTATGACACGGTGAACCAGAGCAAAACCCCTTTCATCACGCACGTGGCCCCCAGCACGTCCACCAACCTGACC
ATGACCTTTAACAACCAGCTGACCACTGTCCACAACCAGGCTCCCTCCTCTACCAGTGCCACTATTTCCTTAGCCAATCCCGAAGTCTCC
ATACTAAACTACCCATCTACACTCTACCAGCCCTCAGCGGCATCCATGGCTGCAGTGGCCCAGCGGAGCATGCCCCTGCAGACAGGAACA
GCCCAGATTTGTGCCCGGCCTGACCCGTTCCAGCAAGCTCTCATCGTGTGTCCCCCCGGCTTCCAAGGCTTGCAGGCCTCTCCCTCTAAG
CACGCTGGCTACTCGGTGCGAATGGAAAATGCAGTTCCCATCGTCACTCAAGCCCCAGGAGCTCAGCCTCTTCAGATCCAACCAGGTCTG
CTTGCCCAGCAGGCTTGGCCAAGTGGGACCCAGCAGATCCTGCTTCCCCCAGCATGGCAGCAACTGACTGGAGTGGCCACCCACACATCA
GTGCAGCATGCCACCGTGATTCCCGAGACCATGGCAGGCACCCAGCAGCTGGCGGACTGGAGAAATACGCATGCTCACGGAAGCCATTAT
AATCCCATCATGCAGCAGCCTGCACTATTGACCGGTCATGTGACCCTTCCAGCAGCACAGCCCTTAAATGTGGGTGTGGCCCACGTGATG
CGGCAGCAGCCAACCAGCACCACCTCCTCCCGGAAGAGTAAGCAGCACCAGTCATCTCAAAGAAAAAACGTCATCAGCTGTGTCACAGTC
CACGACTCCCCCTACTCCGACTCCTCCAGCAACACCAGCCCCTACTCCGTGCAGCAGCGTGCTGGGCACAACAATGCCAATGCCTTTGAC
ACCAAGGGGAGCCTGGAGAATCACTGCACGGGGAACCCCCGAACCATCATCGTGCCACCCCTGAAAACCCAGGCCAGCGAAGTATTGGTG
GAGTGTGATAGCCTGGTGCCAGGTAATTTGGGGCCAGGACAGGGCAGGAACCTCTCCCTGGAGAGTGGTTTTCCTGCTTTTCTGCTGCTA

>53289_53289_1_MFSD8-HIPK2_MFSD8_chr4_128870958_ENST00000296468_HIPK2_chr7_139305309_ENST00000342645_length(amino acids)=371AA_BP=
MEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQAPSSTSATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPL
QTGTAQICARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAWQQLTGVA
THTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSSQRKNVIS
CVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPGNLGPGQGRNLSLESGFPA

--------------------------------------------------------------
>53289_53289_2_MFSD8-HIPK2_MFSD8_chr4_128870958_ENST00000296468_HIPK2_chr7_139305309_ENST00000406875_length(transcript)=13661nt_BP=326nt
AGGTTACAAGCAGCAGATCCCACCTTCAGTCCTGGCTCTGACAAGCCCTCCAGCTTCACGCCACCCGGGATGGGAGAAAGCAGGTGTCGC
GAGAGTTGGGCGCAAGACGCCTTGTAGGGAGTGTAACTATGGCCGGCCTGCGGAACGAAAGTGAACAGGAGCCGCTCTTAGGCGACACAC
CTGGAAGCAGAGAATGGGACATTTTAGAGACTGAAGAGCATTATAAGAGCCGATGGAGATCTATTAGGATTTTATATCTTACTATGTTTC
TCAGCAGTGTAGGGTTTTCTGTAGTGATGATGTCCATATGGCCATATCTCCAAAAGCGTCAAATCATGTTTCCAGAACATGGAGATCTGC
AAGCGTCGGGTGAATATGTATGACACGGTGAACCAGAGCAAAACCCCTTTCATCACGCACGTGGCCCCCAGCACGTCCACCAACCTGACC
ATGACCTTTAACAACCAGCTGACCACTGTCCACAACCAGGCTCCCTCCTCTACCAGTGCCACTATTTCCTTAGCCAATCCCGAAGTCTCC
ATACTAAACTACCCATCTACACTCTACCAGCCCTCAGCGGCATCCATGGCTGCAGTGGCCCAGCGGAGCATGCCCCTGCAGACAGGAACA
GCCCAGATTTGTGCCCGGCCTGACCCGTTCCAGCAAGCTCTCATCGTGTGTCCCCCCGGCTTCCAAGGCTTGCAGGCCTCTCCCTCTAAG
CACGCTGGCTACTCGGTGCGAATGGAAAATGCAGTTCCCATCGTCACTCAAGCCCCAGGAGCTCAGCCTCTTCAGATCCAACCAGGTCTG
CTTGCCCAGCAGGCTTGGCCAAGTGGGACCCAGCAGATCCTGCTTCCCCCAGCATGGCAGCAACTGACTGGAGTGGCCACCCACACATCA
GTGCAGCATGCCACCGTGATTCCCGAGACCATGGCAGGCACCCAGCAGCTGGCGGACTGGAGAAATACGCATGCTCACGGAAGCCATTAT
AATCCCATCATGCAGCAGCCTGCACTATTGACCGGTCATGTGACCCTTCCAGCAGCACAGCCCTTAAATGTGGGTGTGGCCCACGTGATG
CGGCAGCAGCCAACCAGCACCACCTCCTCCCGGAAGAGTAAGCAGCACCAGTCATCTGTGAGAAATGTCTCCACCTGTGAGGTGTCCTCC
TCTCAGGCCATCAGCTCCCCACAGCGATCCAAGCGTGTCAAGGAGAACACACCTCCCCGCTGTGCCATGGTGCACAGTAGCCCGGCCTGC
AGCACCTCGGTCACCTGTGGGTGGGGCGACGTGGCCTCCAGCACCACCCGGGAACGGCAGCGGCAGACAATTGTCATTCCCGACACTCCC
AGCCCCACGGTCAGCGTCATCACCATCAGCAGTGACACGGACGAGGAGGAGGAACAGAAACACGCCCCCACCAGCACTGTCTCCAAGCAA
AGAAAAAACGTCATCAGCTGTGTCACAGTCCACGACTCCCCCTACTCCGACTCCTCCAGCAACACCAGCCCCTACTCCGTGCAGCAGCGT
GCTGGGCACAACAATGCCAATGCCTTTGACACCAAGGGGAGCCTGGAGAATCACTGCACGGGGAACCCCCGAACCATCATCGTGCCACCC
CTGAAAACCCAGGCCAGCGAAGTATTGGTGGAGTGTGATAGCCTGGTGCCAGTCAACACCAGTCACCACTCGTCCTCCTACAAGTCCAAG
TCCTCCAGCAACGTGACCTCCACCAGCGGTCACTCTTCAGGGAGCTCATCTGGAGCCATCACCTACCGGCAGCAGCGGCCGGGCCCCCAC
TTCCAGCAGCAGCAGCCACTCAATCTCAGCCAGGCTCAGCAGCACATCACCACGGACCGCACTGGGAGCCACCGAAGGCAGCAGGCCTAC
ATCACTCCCACCATGGCCCAGGCTCCGTACTCCTTCCCGCACAACAGCCCCAGCCACGGCACTGTGCACCCGCATCTGGCTGCAGCCGCT
GCCGCTGCCCACCTCCCCACCCAGCCCCACCTCTACACCTACACTGCGCCGGCGGCCCTGGGCTCCACCGGCACCGTGGCCCACCTGGTG
GCCTCGCAAGGCTCTGCGCGCCACACCGTGCAGCACACTGCCTACCCAGCCAGCATCGTCCACCAGGTCCCCGTGAGCATGGGCCCCCGG
GTCCTGCCCTCGCCCACCATCCACCCGAGTCAGTATCCAGCCCAATTTGCCCACCAGACCTACATCAGCGCCTCGCCAGCCTCCACCGTC
TACACTGGATACCCACTGAGCCCCGCCAAGGTCAACCAGTACCCTTACATATAAACACTGGAGGGGAGGGAGGGAGGGAGGGAGGGAGAG
AATGGCCCGAGGGAGGAGGGAGAGAAGGAGGGAGGCGCTCCTGGGACCGTGGGCGCTGGCCTTTTATACTGAAGATGCCGCACACAAACA
ATGCAAACGGGGCAGGGGCGGGGGGGGGGGGGGGGGCAGAGGGCAGGGGGACGGGTCGGGACACCAGTGAAACTTGAACCGGGAAGTGGG
AGGACGTAGAGCAGAGAAGAGAACATTTTTAAAAGGAAGGGATTAAAGAGGGTGGGAAATCTATGGTTTTTATTTTAAAAAAGAAAAAGG
AAAAAAAAAAAGTCAATAACAAAAAACCCAGCTCAAGAACCCATTCTACGCCAAACTGGAAAGGAGAAGAGAGCAACAGGAAGATTCCAG
AAACGGGGGGCCCCAGTTTTTGAAGAACTTTATGAACTTTTCAAAGATTATTTTCATATGGCAGCAAGTGATACGGAAGACTGCTGTCAG
GGACACCTGATATGGAAATCAAATAGATTTTTAATTAATTGAACATAAGATTTAGGGATTTTTCCAGAACTCGAAAGGGTCAACAGCCCT
CCAGAATGTCGGGCTGCAGCCTGAGGAGGCTGATGTTTGGAGCTGGTGTGGGATTGGCGAAGCCCAGTCCGGGCTCCCTAGTCAGGAAAG
ACGGGGGACGGCCAGGCTGCTGGAAGGCCCCCGGGGGCGCGGGGCGAGTTTTCTTTTTCTGAGCACTCTGGATAAATCCCTAAGCAACGT
TGTTTCTCAAATGTCATTAATAATGTGTGTTGCAAACTTTAGGTTTTTTTCTTTTCTGAAAATGTATTTTCTCTTTGAATCCACCCCTAG
TCGCGTAGCGTAGGGCTAGCGGTCGTCACAGACACCCTAGTAGAATGTAGCACTCAGCACCCTTGTCTCCTACCTTGTGTTCAACTCCAA
TGATACCAATAGAATATTCCTCAATGTAATTGCACAAAAAAAAGCGATATAACATAGGCATGTAACCAATGTGGCGGTGCAGGTGTGCGG
GTGAGCGAGCACGTGTGGGTGTGCACGCGCCGCCCTCCCCGCGTGGCCCTCGGCGCCGCCACCCTAGCTGGCGCAGTCTTGACACTGCAT
CCTTCCCTCCTAGTGCCTTACCGAGCGACAGACGCGGCGTGAGGGTTTACTTCCACTGGTACTCCAAGAAACTGAGGCTAGTCAGACACA
ATCTCAGCTCTTCTGTTGTGCTGTTGTAACAGTTTACGCTGGCCTTTTTTTTTTCTTTTTCTTTTTCTTTTTAAAATGTTAATGCCCGTT
GTCTTTCCTGGGCTGTTTGCTAGCGGAAGGATGCCAGGGAAGCCAGCAGGAGCTAGGAGAGAGTCCGTGGATCTCGAAAGAAATATGGGA
GACAGATGCCCGGCGGGTGCGTCTGGAGATGGGGACGGCGGGAGTTGAGTTGTGGCAGTAGTTGAGTTGTAATTTGTGGGCGGAGGCCCA
GAGAGACTCCCCACCCTTCACCCCTGCCCCACTCTGTCCCCAGTTCCGCCATTTGTGAGGCCAGAGGTTTCCGGACTGTTGGCCTCGCCA
GGCAGCCGTCTCCCGCCCCAGGCGGCATCCCCCAGTCCCTCCCGCCTCCACGAGAGCCTGGAGCTCTCAGCCTCGCCCGGGGCTCCACTC
TCTCCTCCGGCTCCCTGGGCTGTTTTGCTCTAACGATCTTGCCAGATCCCTCCCTCTGTAGACAACCACCAACCTCTGTTTGCTGTTGAA
TTCTCTCCTCACATTACCCAGGTCTGCTCAAGACATGATTTTGGTTTTGGTTTCTGAGGGTTCTAGTGGGCAGAAGGTTGGAGGGACACT
TATGAGGGTGGCCGGGGGTCTGACGCTGCACTTTGGAAAAACTCACACAGTTGAATTTCCAAAGAAATCTGCCCTTTGCCCTCTTTGCAC
CTTTGATACATTCTGGAAGTTTTCTCAGGCTTTGGACACTTCTGGGGATGGAGGTGTGGAGAAGTGGGGAGTTCCCTCTCTTCATAGTAA
ATAACTCTGAAATATGTGAATGTGAATGGCAGGAGAATCTGGCCAAGGATGGGGCCGAAAAGGGTGGTTCTAATTGTTTGCTTCTGATGT
TGAGTCTTTAGCTGACCCCACAGGCAGGTTTCCAAGGTGCAAAGAGATCTTTCCCGAGTCAGCGGCCCCATCCTCATCCTCCCTCCCTTT
ACTTCCTCACTGTGCAGTCTCCCTCAAGGATCTACTGTGAAAGGTGTGTTTGTAGTGATATCCAACCTAACTCAGTAACGAAGTCGTTAC
TTAGCTCTTAGCTGTGAAATAACTCTGGAAACTTCCCCACCCCAACCATAAATTCTTACTTATAAAGAAACAGGTCCCCAAACTGGAAAC
AGCTTAGTCCAGGCCTCAGCGAGAAGGAAGGACACCATGACTGCTCCATGCTGGGCACAGCCGGGCAGTCTTGCCAAGTGCCTGCTGGAG
GCTGTGCCGGCAAGAGGCCTGCAGCAAGGAGATTCCCTTCCCTCGGGCCATTATCAATACTGTCTTTATCTGGAGGTGGGGAAGCGCAGC
CCTCTGAGACAGCAGGACAATGGTCAGTTCAGAGAGGGTGAGGGCAGCAAACGCTTCAGAGGACACAGAAGCCAGAGGACCCCCCCCCGC
CCCACAGCTGGGTCAGCCTGGAAAATCCATCTATTAGGGACTTTTTGGCAGCCAGATGGCAGCAATAGCCCATTAGGTCTCATCCCGAGT
TCCAAGTCTTGGCTGCAAATGAGCCTCAGTTCGCCTTACTGGAGAGCACCCCCAGATTCCTGGGCACAGTTCATTTCCAGCCCTTTCTAG
ATCTGATCTTTTAGGGGGAAAGACAGCTTAAAATGTTCTTTTCATTTTAAAGAAAATTATTCTGTCTGCTTAAGTTGGAGGCTACTTACT
CTTTCACCTGACATTTTCTTTCCTTTTATTCTTCCAGATCAGGAATGAAATTTCCATGCTGCTCATAAAGATAATATTATTGTACTAATT
ATTTTTATTACCATTGTAATTATGATCATTATGTTGATATTTTAGTCAGGGTTTTAAATGCACATTTATTCCAAGTATCTTTGTGTTTTC
TCTTTAATATTTAAACTTATTCTCTCTGTGAGTATATAAGTAGACTGGAGGGACATCCAGATGTCCAGTTTTGTCAGGCAAAAAAAAAAA
GGAAAGACTTAGGAAGTAGGAAAATTGTTTCTGTCATCTCTATCCCAACAAGAGACGTCAAGAAAGATCCACCACAGAACAAAAGTTTAA
AGAAGAATCAAAGCCTTGATTGGGCTTCTGACAACATGGTCACCATCAAGGTTGTCATTTTCTAGATCCCAGAGGCCTGGGATGCGACGT
CAGGTGGCATCTCATGGGCTCGGGGAATGTCGAGTCACTGACTGTCCAGCCCTTAGCCAGCTTCTCTCCCACATCCTCAGAGCTCTCCTG
TGCTTCTGAAATCTGTTAACTAAATCTTTGGCTTGCCTCTGGTATTTAAGCAAGAAAATTCCCTCCCAGAGGTGACCCCATCCGCTTCCC
CACAATCCATCCTTTTGCCATCGGCGCACCTGGGGCGTGGCTTAGGTTCTTCAATGCAGGGACATTTGCCCCCTCCCAGAAGCTGCTGGG
CACAGTGAGGTGGCGTAAGAGTGACTGGCAGGTGGTACCTTCCCCAGGAAATTTCACCACACCACCCAGTTCCTCAGCCTGCCCCCTCCC
CCTGTGATGCATGCCCCCAGCACCCAATTCTAGCCAGCTGGAAGTGGGTGGAGGGACAGCAGGAGGCCAGAGAAACCCTGAACAAAGCTG
GGCGGCTGCTCAGGCATCACAGGCTGCACCCCCTCTGAAAGCATCCCCACTGGGCTCCGGCCACATCTTCAGTGCACTGTGCTGTGTGCG
CTGGGTGCTCACACGCTGTCCCCAGACCCACAAAGTGCTAGGCCCCAGTTGAAGAAAGGGGTGAAATAGCCAGCTTCACCGAAGGGAAGG
GAAGGGAAGTATTGGGCGATGCCAGCCCCACAGACGCTCAGCAAACATTAGTGCACATTCTCCTAGTCCTCACCCAATGGCCTCCTCTAC
CCCCATGCATGGAGCTGCCACATCAGAAGCCCCAAGAGAAGCTCCCTGCAGGAGAGGCCAGCTCCCTGGATGCCCAATTGCATACCTGGC
CGAATCTGCCATTGAGTCACCTTAGCAAATAGGCTGCTGTCACTAGGACCAAGCTCTCAAGCAGAGGGATGCCAACCTAGTCCTTACTTA
GCCCACGAATCATCTAGAGCATCCTCTAGTCTTTTGTGGGCTCCCTCCTTCCCATTTGAAGAGACATTGTTCAGAGGAAGAGGGGAAGAT
TTGAAATGTCAGGTCACGGAGGAGTGTTTAACTGGAGCCTGGTGAACCGCAGGGCAATTTGCTTCTGCTCACTGGGTTCTGACTGGCCCG
TCTGGACGTGGGCCCCCATGTCTCTGTGCTTAGGGCCTCTTCATGATGTTTTGGATGTTTCCAAGGGAAGTGGGTGAGCAGATCAAGGGG
TGGGAGAGTCGAGGCTTGATGCCAGTTAATACTGTGAAGTGGAGCGTGCGGTCAGTGGAATTCAGAGGAAAAAGAAGGGTTGGAGCAAAG
CGGCATTCATCTCCTGGACTGTTAGCCTTTCTAGTCTTCCTGGTGGCTGAGGTGTTCACGGGCTGGGGGAGCCAGCTGACCTTTGTCCTC
TTCAACCTAGAAGACTCAGCCCGCCCAGACACCAACGTGTGAGACGGATGGACATCAGGAAGGGAAGGGGAGATTAGCCCAACTGCTGAC
AGAACGATTTCCCTTGGTTGGACCTTGGGAATGGCAAACACTCATATTGGAACAAGCTTGGGGTGGAAGATTTAGGCCGTGTGAGCATGT
GTGAGTGAGTGGAACAAACTTTCTTGGAAACTGGAGGGAGGAGATGAGGAGGCTTCGGGAAGTATTACTGATGGCTCATGGTTGAGAGAG
CGACGTGGGGACCCAGCTCGCCCCAGCTTTTGTCCCAGGTTCTCTTTGTCTGATGCTGAGGGCAGGGTGGGGTGTGGGACCACCACTCTT
GTTGGCCTGTCAAGTAGACCCTAGGACAGAAAATGGAAAGAAGGAAATGGCTCGGTGCTCTCAACTAGCAGAGAGAATTGAGGAGAGGTA
AGGGTTCCTTCTGCAGGCCAGCCTGGGACTCCACAGCGCCAGCAGGAGTGACTTGGCCACAAGACATTCCAGCCCCAGGGACTTTGCAGG
CTTCATTCCCTGTCTGTGTCTTTTCCTTCTGGTGTGTTTTACAGACTTCTGATGGGGAAGCTTCAAACTTGAGCAGGCCAGAGATGTCCT
TACCAAATTGGAAAGGAAGGTGAAACTGTTCCTTTCTTTAGCCAAAGAACCCTTCTCAAAGACGCCTCCAGAAATGGACAAAATGGCCTT
CCCTTCGTTCCTTTCCAGGCAATAATGACATCATTAGTGATGCAATTCTATTTGTCTTTCTCTTTCCTCTCTGTCCTTTTTTTTAAAAAA
AAAAAATGCATTTATTTCAAAACTGTGCTATTCTTTTAAGAGGAGTGGAGGTGACCCCTTCGATGCTGCTGCTATCGGGAGACAAGGTGC
CATACCAATACGTGGGCTTGACTAATCCCAGGCCACCATGGGAGAGAGCAAAGCAGGGCTGCCAGGAGTTCAGTTGCATCAAGGGCGTAG
AGCACGCGGGGGCTGGGCTCGGAATAGCAGTACTTTTCCACTTTGATGCCTTAGAACTCTCACTTCTCATCTCCACAGACCAGACTCAGT
AAAATCTCAGGCCACTAGAGAATGGAAGGCGGTGAAACAGGATTTAAATGCAAAAAAAACCTATTGGAGGCTTTTGGCACCGTGGCTCAC
TAGAGGGACCCAGCATAGTAGAGGTTTCTCTTGTTGCAGCTTCTGAAAAGTTCAAAAAAGAACTCCAGGCCGTTCTTCCCTCAAACCCAG
TGAGAGTTTGCAGAGAAGTGCCCCCTGCAGGGCTCCCGTCCCAGAACACCAGCACCAGAGAGGGTCTTCCCGATGCCCCCCGCTGGACTT
GCCCAAGCCTCTGGGAGCCCCTCATCTCAGATCCCTGTGTTGAACATGACACTGACTGTCCCTTATTTGTTAAAATTTGCAATATCTCTC
AAGTAAATAATAGCCAACATTTGTTGAATGCTTTCATGACTCCCGGGCTAAGGCCTTTATGAGCGTTGTCTCAAGGGGCCCCAACAGCCA
TCCCACAGGGAGGGGGATAACAGCCCCCATTTATAGATAAGGGAGCTGACCGGATGCTCTGAGAAGTGGCAGGTGTTGAAGGAAGGATAA
AGCAGTGATGGGCCAGAATCCCCAAGGTTCCCTTTTTTGTTCATCAGGCCCTTCCTGAGATGTGATTTTTAATCTTTTAACTTTTTTTAA
TTAATAGCAATGCGTGGCCTCATATTTCTATGAACCATTTAGTGATACTCCCGCTTCCTGCATGCCACACACTGTGCTGGGAATTGCTCA
TGGGTTGTCCTGTTTCATCTTCTCCGTAGCCCTGTGAGATCGGCAATATTAGTCCCCCTACAGCCAAGGAAACTGCCCAGAGCCACACAA
CTCTTGAGGGGCGAGGAGGGCTTGAACCTGAGTCTGCCCAGCTCCAGAACTGAGCTTGCAGCCATTAGCCACAGCTGTCTCCTGCATGTC
TGAGCAAAGAAAGGCCTTTACACAGCATCACCCTGTGCCATCCCATGCACCGTGGGACTCAGCTAAAGGACTGTGCAAAGAGGGGGCTCC
TGAGTTGGATTTAGGCAAAAGGGGCAGAATTCGTTTGATTTTTAGAGAAAATCTCTGGAGAGTTTCTTTTGATTCATAGAATTCCTTTTA
GATTTCTTTCCAGCATACCAACTAGCTTTAGTAGTGCTGCTACAACCAGCTCTTATAAGTAAGAGTGAAAAAGTATTCTTTTCTTCTTTA
AAAAATAAGTTTTTCTTGCTTATAGTTAATTCTAGAAAGGCAATACTAAAGGTATATATTTTTTTCAAAATGCTATTTTTTACTGCACTT
GATAATTATCCTGACAGCTCTGATCTCTGTAATAGATTCACTCTTCAGCTCTGGGCAGAACCAGAGGCAGGGTTCACACCAAATTTGTAA
ATACCATATGTGGGTCTGGTGTCCAGGAACTTTTTTCTTTCTGTTAAAAAAAAGAAAAAAAAAAGAAAAAAAAAAAGAAGTAGAGGTGGA
AGAAAGACAAGACTTAGAGGAACAAAAGAATGTTTTCTTTTGAGATACTCTTCTCAAAGAAATAGCAACAATTGTATAAACAGGAAAACC
AGCCAGCTTTCATGATAAAAGGAAGGCGTGTCTCTTGCCCTGGTATGAGATTAACAGAAATACAGATGCATTTTTATTTTGATTGAAAGA
TGGTGAGAATGTAGAAATGCTTAGGACTAGATTTTTAATTTTTTAAAATAACTATTATCATTTATTATGAAATATTTGTTCAGTTGTTTT
GAGTGGGTTTCTTGTTCCTTTTTTCATTTAAAACCTTCTTTGTTGACTGGCTCCAGGCTTGTTTGCCTAAATTCTTAGGTAGTTTACACA
AGTTCTAGAATCTTTTAGAACTTTAACTCCATTGGAAGCAAACCTAACTAATCGGAGTTTGAGATCCTGGTTGGTTTCAATAGGTATTCT
GGAATTCTGGCAGAACACCTAAAGATTTTTTTTTTTTTTAGAAGGTTTTAGATACATTATCTTACACAAACTGTGACCTAATGGCAATAA
TTACCTCAAATGTGGGCATTCATCCTGGTTTTAGCCTTTTTTGAAATCATGTAGCCAGCTTGATCTTGGAATTTAAAGACTATGAATTCT
CTGTGGGCTGAAAATAATGATTACTTCATACCCCCGGTCATCGTTGCTTAAGTGAATTCTGAAAATAGCTCATCTTTACAACAAAAATTA
AACCAAGGAAGAGATTATTCTTTGTGTGTTGTACTCAAATGCGATGTTCAAATGCACATGTTAAGTATATATGTTTTTAGCTACTGTAAA
ATGCTGTTAGCCTTCTAAGCTATCAAAACAGTCACATTTTAAATGAGTAAACTAAACAATTGACTGTGGATACTTAAGCATATTTCTGGC
TACGTTTTATAGTTAAAGTGTTTTATAGTTTACATTTAGACTGGTACTTTTTAAAGAAAAGTTCTGTTTATAACTGACATCCGCAAACCC
CAGTGAATGCCTCTTAGTTGGAGGTTGTGTCTCCCCCAAGGCAAGTGTGTTGTCCCAGACTCTTCTGTAGTCCAGCATGCGCACTTCCCT
CTGGATTATTACTTTCCACGTGAACTCAAGAGAACATGAAAGGCAATCCAGATGGAGGGAAAAGGTGTGAGTCCGCAGCCCGGGCCAGAT
GCGAAGGTCTCATGCGTGTCGTCTAAACACTTGTCTTCAAGGCCTTCTCTCTGACATCTTGGAAGAGTCATTGAGAACAGATAACCTGGT
TCATTGATTTTTGTCTTGATTTGAATATTTAACTTATTAATAGATCCACTGATTTCCAGGCACCAGGCAGTAGAAGAGACTGGGATTCAG
GTGACCATGAAGGCACAGCTGCTACTTCTGGGCCGGGGGTGATATTTTGATCAGCGTTTTGTAGGGGAGGACCATATACCCCTATTCCCA
TGGTCGCTGGCTGGGTTTTCCATATATCTGCTGTCATTTATTCGTTTTCCCCTTAAAAGCAAAATCAATGTAAAAGGCTATGTTTACGTT
TTACTCATTGTCCAGCTTAGACTCAAAGTCTAGTTCGGTGGGAGGGGGACCTTAGCATCCTCTCAGAGATGGTCAGGGCTGAGCAGGAGG
AGGCAGAGACAGAGGGGCAGCTCAGCCTGGTCCATTGAGACCCACTCTAAACAGACATCATATTTGGAACAAGAAGATGCTTCGAGACAG
GAATGGGCCCCACTGTCATGCAGAAACAGACTGGGGGAATGGCAGTTTCCCTGAGTCTTGGTTTCTTTTATGTTTTCTCTTGTGCCACCA
CCAAACTGCAGAGGACCTGCTGTGACCTAAAGGGCATTCCTTTAGCAGATAAGACCTTGAAAACTGCAAAACACCTGGGACCAGGGAGCT
TTTAAAAAATACAAAAAAATACCACATTTGCTTTTTCCCTGTGAACTGTATTGACAGCGTGTTCTTAGGACAGTCTTTTGGTGGAAATGT
TACTGTAAAATAGTTTTCATCTCACCCCTCCTAATCATACTCCCACTTTCCTGTTTGTGTGGTGGTGTTGCTGTTTTTTCCTTTACATGA
ATTAACCAAATGAATTTTGTGTCATTGTTTTTGGGGCTTATATTTTTAAAACATAGAAATTGCCTTTTGTTCATTTGAAAAGTAAGTATG
TTGTATCTGAAAAAGGGCTCTGCCTCTGCTCTCCCTCGCTTCCTTGTAACCAATCTCCAAACGAATCTCTCCTGGCACCGCCCCCTTCCT
TATATAGGGTCACTGTCCCCGGGGCCACCTCTGCCTCCACCCTGCTGTCACCACTGCCCTGGGCCAAGGCACCCAGGACTCCCAGAAAGC
GCGAGAGCCAGCAAGAAGGCCCCACTCAGCCTTGAGACTGGTGGTCACACCTCCCTGTCAGAGTCGCCTGCTGGGCTGAAGGGGCAATGG
ATTGTCATTGTTGAAATTGTTTGGCTCAGGTTATAAGGAGGAACTTGGGAAGTAGAAAGTGACTTGACCATGTGCATCCTTGGTAGCTTC
CTGTAACTAACAAATGGAACAGAGAGCACACCCCCGCCCCGCCCCACCCCAAGCAGATGTTCCCGTCAGCGCTGCCCTGAGTCAGTCGGT
CCCCCGTTTCTGCTCTCCTCCCTTTTGTGTTCCTGCTCACTTCAAGCTTCTTCCATGGACTTTCCAGGGCACAGTCATCTCTAGCCCCCA
AATCATCTCTTCATCCTCTGTGTGTGCATTTTTTTAACCAAATGAAATAGACAAGAAAGTCATACTTTGGGGCAGCAGAATTTCTAATTT
AGTAGAATCACTGTATAGAGATAGATGTTGATATATATGTTTGTGTATATATATCAAACCAAATTGGATAGGAGAAGTATAGCTTTACAG
ATGAGGAGAAGGAGCTCTTTAGAGGTCGGAGTCAAGACTGGTGTCTTGGACGTGCATGGGCTGTGTCCCAGGCCACTCCGCACACATGGG
GCTGAGGCGTGGCGCCGGGCCCTTGTCATCCACCTCACCACGGCAGAGCCAGCAGGCCCTGTAGGGTGCTGCTGCTGTCTCACTGGGTCC
CAGCTTCAAGCGCATCAGTGGGTGACGGGGGCAACAAATCAGAGTGACTGGAAGTTTCCATCCCGTTTTGCTTTGACCACGTGTACTGAG
CTGCAGCCTCTGATACTCTGTCACGTTTCCAAAAATGGTATCCATTAGGATAGAAAGAGAATGGATCTGCAGAAATGTTTACCTTTCAAC
TGCTCATGAATTCAGGACACTGGATAGAAAGACTCACTCCCCAAAATGAGAACAGGGAAGAGGAGACCCGGCGACACTAAGTCACCAGGT
CCAAGGAACGTGGCTCCCTCCCCAGGGTCATCTCACCTAGATCTTTCTCTCCCAGGTCATCTCAGCTCAATCTCAATAACCCTATGAAAG
CCCTGGTCTGTTGTGTTCCTTCACCGTACGGTTTCTGTAATAAAAAGTGTTAATCCATGTTAATCTGTGTGAAAATTATTGCGTGCAACA
GTATTTTCTCGTGTACCTCTTTTTCCTATGTGAATTGTCCCTCTTTTTTATTTATAAATGTCTACTTTTGTTTTTTTAAAGACAAACCAA
TGTGTTGTAGACCTATATGTAACCTATTCCTTAGTCTCATATTATAGGTATGTTATAAGAATGGATATTTTACTTGGCTTTAGAATGTTT
TACAAGAAAACTAATTCTTAACTGATCAAGTCCTTGCTACTAAAATGCTTGTGTTTTTCATCATGACGTCGTGTGCTTCTAAATTAATCA
TTTTCGTTGTAGAAAAATGGAGTGAATTTATATTAGTCTTGGAAACTAATAATAGCATTGTAAATTTATGAGATGATTTTAACAGAAAAA
ATATAGAAGAATATAGTTATTTTAATTGTAATATTACTAACTGTAGGGTGAGAAAAAGGGGGGGGGGTCCCATTGTGGTGAACTATGTTA
TAGCTTGTTACTCATAGTTTCTTTTTGATCATTTTTTCGGTCTCCGAGGTGAAATGACTTATTAATTAAAATTTGTAAACTCACATATGC

>53289_53289_2_MFSD8-HIPK2_MFSD8_chr4_128870958_ENST00000296468_HIPK2_chr7_139305309_ENST00000406875_length(amino acids)=651AA_BP=
MEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQAPSSTSATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPL
QTGTAQICARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAWQQLTGVA
THTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTC
EVSSSQAISSPQRSKRVKENTPPRCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHAPTST
VSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSS
YKSKSSSNVTSTSGHSSGSSSGAITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSHGTVHPHL
AAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASIVHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASP

--------------------------------------------------------------
>53289_53289_3_MFSD8-HIPK2_MFSD8_chr4_128870958_ENST00000296468_HIPK2_chr7_139305309_ENST00000428878_length(transcript)=2521nt_BP=326nt
AGGTTACAAGCAGCAGATCCCACCTTCAGTCCTGGCTCTGACAAGCCCTCCAGCTTCACGCCACCCGGGATGGGAGAAAGCAGGTGTCGC
GAGAGTTGGGCGCAAGACGCCTTGTAGGGAGTGTAACTATGGCCGGCCTGCGGAACGAAAGTGAACAGGAGCCGCTCTTAGGCGACACAC
CTGGAAGCAGAGAATGGGACATTTTAGAGACTGAAGAGCATTATAAGAGCCGATGGAGATCTATTAGGATTTTATATCTTACTATGTTTC
TCAGCAGTGTAGGGTTTTCTGTAGTGATGATGTCCATATGGCCATATCTCCAAAAGCGTCAAATCATGTTTCCAGAACATGGAGATCTGC
AAGCGTCGGGTGAATATGTATGACACGGTGAACCAGAGCAAAACCCCTTTCATCACGCACGTGGCCCCCAGCACGTCCACCAACCTGACC
ATGACCTTTAACAACCAGCTGACCACTGTCCACAACCAGCCCTCAGCGGCATCCATGGCTGCAGTGGCCCAGCGGAGCATGCCCCTGCAG
ACAGGAACAGCCCAGATTTGTGCCCGGCCTGACCCGTTCCAGCAAGCTCTCATCGTGTGTCCCCCCGGCTTCCAAGGCTTGCAGGCCTCT
CCCTCTAAGCACGCTGGCTACTCGGTGCGAATGGAAAATGCAGTTCCCATCGTCACTCAAGCCCCAGGAGCTCAGCCTCTTCAGATCCAA
CCAGGTCTGCTTGCCCAGCAGGCTTGGCCAAGTGGGACCCAGCAGATCCTGCTTCCCCCAGCATGGCAGCAACTGACTGGAGTGGCCACC
CACACATCAGTGCAGCATGCCACCGTGATTCCCGAGACCATGGCAGGCACCCAGCAGCTGGCGGACTGGAGAAATACGCATGCTCACGGA
AGCCATTATAATCCCATCATGCAGCAGCCTGCACTATTGACCGGTCATGTGACCCTTCCAGCAGCACAGCCCTTAAATGTGGGTGTGGCC
CACGTGATGCGGCAGCAGCCAACCAGCACCACCTCCTCCCGGAAGAGTAAGCAGCACCAGTCATCTGTGAGAAATGTCTCCACCTGTGAG
GTGTCCTCCTCTCAGGCCATCAGCTCCCCACAGCGATCCAAGCGTGTCAAGGAGAACACACCTCCCCGCTGTGCCATGGTGCACAGTAGC
CCGGCCTGCAGCACCTCGGTCACCTGTGGGTGGGGCGACGTGGCCTCCAGCACCACCCGGGAACGGCAGCGGCAGACAATTGTCATTCCC
GACACTCCCAGCCCCACGGTCAGCGTCATCACCATCAGCAGTGACACGGACGAGGAGGAGGAACAGAAACACGCCCCCACCAGCACTGTC
TCCAAGCAAAGAAAAAACGTCATCAGCTGTGTCACAGTCCACGACTCCCCCTACTCCGACTCCTCCAGCAACACCAGCCCCTACTCCGTG
CAGCAGCGTGCTGGGCACAACAATGCCAATGCCTTTGACACCAAGGGGAGCCTGGAGAATCACTGCACGGGGAACCCCCGAACCATCATC
GTGCCACCCCTGAAAACCCAGGCCAGCGAAGTATTGGTGGAGTGTGATAGCCTGGTGCCAGTCAACACCAGTCACCACTCGTCCTCCTAC
AAGTCCAAGTCCTCCAGCAACGTGACCTCCACCAGCGGTCACTCTTCAGGGAGCTCATCTGGAGCCATCACCTACCGGCAGCAGCGGCCG
GGCCCCCACTTCCAGCAGCAGCAGCCACTCAATCTCAGCCAGGCTCAGCAGCACATCACCACGGACCGCACTGGGAGCCACCGAAGGCAG
CAGGCCTACATCACTCCCACCATGGCCCAGGCTCCGTACTCCTTCCCGCACAACAGCCCCAGCCACGGCACTGTGCACCCGCATCTGGCT
GCAGCCGCTGCCGCTGCCCACCTCCCCACCCAGCCCCACCTCTACACCTACACTGCGCCGGCGGCCCTGGGCTCCACCGGCACCGTGGCC
CACCTGGTGGCCTCGCAAGGCTCTGCGCGCCACACCGTGCAGCACACTGCCTACCCAGCCAGCATCGTCCACCAGGTCCCCGTGAGCATG
GGCCCCCGGGTCCTGCCCTCGCCCACCATCCACCCGAGTCAGTATCCAGCCCAATTTGCCCACCAGACCTACATCAGCGCCTCGCCAGCC
TCCACCGTCTACACTGGATACCCACTGAGCCCCGCCAAGGTCAACCAGTACCCTTACATATAAACACTGGAGGGGAGGGAGGGAGGGAGG
GAGGGAGAGAATGGCCCGAGGGAGGAGGGAGAGAAGGAGGGAGGCGCTCCTGGGACCGTGGGCGCTGGCCTTTTATACTGAAGATGCCGC
ACACAAACAATGCAAACGGGGCAGGGGCGGGGGGGGGGGGGGGGGCAGAGGGCAGGGGGACGGGTCGGGACACCAGTGAAACTTGAACCG
GGAAGTGGGAGGACGTAGAGCAGAGAAGAGAACATTTTTAAAAGGAAGGGATTAAAGAGGGTGGGAAATCTATGGTTTTTATTTTAAAAA

>53289_53289_3_MFSD8-HIPK2_MFSD8_chr4_128870958_ENST00000296468_HIPK2_chr7_139305309_ENST00000428878_length(amino acids)=624AA_BP=
MEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPPGFQG
LQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAWQQLTGVATHTSVQHATVIPETMAGTQQLADWRNT
HAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPPRCAM
VHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTS
PYSVQQRAGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGAITYR
QQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSHGTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGST

--------------------------------------------------------------
>53289_53289_4_MFSD8-HIPK2_MFSD8_chr4_128870959_ENST00000296468_HIPK2_chr7_139305309_ENST00000342645_length(transcript)=1464nt_BP=326nt
AGGTTACAAGCAGCAGATCCCACCTTCAGTCCTGGCTCTGACAAGCCCTCCAGCTTCACGCCACCCGGGATGGGAGAAAGCAGGTGTCGC
GAGAGTTGGGCGCAAGACGCCTTGTAGGGAGTGTAACTATGGCCGGCCTGCGGAACGAAAGTGAACAGGAGCCGCTCTTAGGCGACACAC
CTGGAAGCAGAGAATGGGACATTTTAGAGACTGAAGAGCATTATAAGAGCCGATGGAGATCTATTAGGATTTTATATCTTACTATGTTTC
TCAGCAGTGTAGGGTTTTCTGTAGTGATGATGTCCATATGGCCATATCTCCAAAAGCGTCAAATCATGTTTCCAGAACATGGAGATCTGC
AAGCGTCGGGTGAATATGTATGACACGGTGAACCAGAGCAAAACCCCTTTCATCACGCACGTGGCCCCCAGCACGTCCACCAACCTGACC
ATGACCTTTAACAACCAGCTGACCACTGTCCACAACCAGGCTCCCTCCTCTACCAGTGCCACTATTTCCTTAGCCAATCCCGAAGTCTCC
ATACTAAACTACCCATCTACACTCTACCAGCCCTCAGCGGCATCCATGGCTGCAGTGGCCCAGCGGAGCATGCCCCTGCAGACAGGAACA
GCCCAGATTTGTGCCCGGCCTGACCCGTTCCAGCAAGCTCTCATCGTGTGTCCCCCCGGCTTCCAAGGCTTGCAGGCCTCTCCCTCTAAG
CACGCTGGCTACTCGGTGCGAATGGAAAATGCAGTTCCCATCGTCACTCAAGCCCCAGGAGCTCAGCCTCTTCAGATCCAACCAGGTCTG
CTTGCCCAGCAGGCTTGGCCAAGTGGGACCCAGCAGATCCTGCTTCCCCCAGCATGGCAGCAACTGACTGGAGTGGCCACCCACACATCA
GTGCAGCATGCCACCGTGATTCCCGAGACCATGGCAGGCACCCAGCAGCTGGCGGACTGGAGAAATACGCATGCTCACGGAAGCCATTAT
AATCCCATCATGCAGCAGCCTGCACTATTGACCGGTCATGTGACCCTTCCAGCAGCACAGCCCTTAAATGTGGGTGTGGCCCACGTGATG
CGGCAGCAGCCAACCAGCACCACCTCCTCCCGGAAGAGTAAGCAGCACCAGTCATCTCAAAGAAAAAACGTCATCAGCTGTGTCACAGTC
CACGACTCCCCCTACTCCGACTCCTCCAGCAACACCAGCCCCTACTCCGTGCAGCAGCGTGCTGGGCACAACAATGCCAATGCCTTTGAC
ACCAAGGGGAGCCTGGAGAATCACTGCACGGGGAACCCCCGAACCATCATCGTGCCACCCCTGAAAACCCAGGCCAGCGAAGTATTGGTG
GAGTGTGATAGCCTGGTGCCAGGTAATTTGGGGCCAGGACAGGGCAGGAACCTCTCCCTGGAGAGTGGTTTTCCTGCTTTTCTGCTGCTA

>53289_53289_4_MFSD8-HIPK2_MFSD8_chr4_128870959_ENST00000296468_HIPK2_chr7_139305309_ENST00000342645_length(amino acids)=371AA_BP=
MEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQAPSSTSATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPL
QTGTAQICARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAWQQLTGVA
THTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSSQRKNVIS
CVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPGNLGPGQGRNLSLESGFPA

--------------------------------------------------------------
>53289_53289_5_MFSD8-HIPK2_MFSD8_chr4_128870959_ENST00000296468_HIPK2_chr7_139305309_ENST00000406875_length(transcript)=13661nt_BP=326nt
AGGTTACAAGCAGCAGATCCCACCTTCAGTCCTGGCTCTGACAAGCCCTCCAGCTTCACGCCACCCGGGATGGGAGAAAGCAGGTGTCGC
GAGAGTTGGGCGCAAGACGCCTTGTAGGGAGTGTAACTATGGCCGGCCTGCGGAACGAAAGTGAACAGGAGCCGCTCTTAGGCGACACAC
CTGGAAGCAGAGAATGGGACATTTTAGAGACTGAAGAGCATTATAAGAGCCGATGGAGATCTATTAGGATTTTATATCTTACTATGTTTC
TCAGCAGTGTAGGGTTTTCTGTAGTGATGATGTCCATATGGCCATATCTCCAAAAGCGTCAAATCATGTTTCCAGAACATGGAGATCTGC
AAGCGTCGGGTGAATATGTATGACACGGTGAACCAGAGCAAAACCCCTTTCATCACGCACGTGGCCCCCAGCACGTCCACCAACCTGACC
ATGACCTTTAACAACCAGCTGACCACTGTCCACAACCAGGCTCCCTCCTCTACCAGTGCCACTATTTCCTTAGCCAATCCCGAAGTCTCC
ATACTAAACTACCCATCTACACTCTACCAGCCCTCAGCGGCATCCATGGCTGCAGTGGCCCAGCGGAGCATGCCCCTGCAGACAGGAACA
GCCCAGATTTGTGCCCGGCCTGACCCGTTCCAGCAAGCTCTCATCGTGTGTCCCCCCGGCTTCCAAGGCTTGCAGGCCTCTCCCTCTAAG
CACGCTGGCTACTCGGTGCGAATGGAAAATGCAGTTCCCATCGTCACTCAAGCCCCAGGAGCTCAGCCTCTTCAGATCCAACCAGGTCTG
CTTGCCCAGCAGGCTTGGCCAAGTGGGACCCAGCAGATCCTGCTTCCCCCAGCATGGCAGCAACTGACTGGAGTGGCCACCCACACATCA
GTGCAGCATGCCACCGTGATTCCCGAGACCATGGCAGGCACCCAGCAGCTGGCGGACTGGAGAAATACGCATGCTCACGGAAGCCATTAT
AATCCCATCATGCAGCAGCCTGCACTATTGACCGGTCATGTGACCCTTCCAGCAGCACAGCCCTTAAATGTGGGTGTGGCCCACGTGATG
CGGCAGCAGCCAACCAGCACCACCTCCTCCCGGAAGAGTAAGCAGCACCAGTCATCTGTGAGAAATGTCTCCACCTGTGAGGTGTCCTCC
TCTCAGGCCATCAGCTCCCCACAGCGATCCAAGCGTGTCAAGGAGAACACACCTCCCCGCTGTGCCATGGTGCACAGTAGCCCGGCCTGC
AGCACCTCGGTCACCTGTGGGTGGGGCGACGTGGCCTCCAGCACCACCCGGGAACGGCAGCGGCAGACAATTGTCATTCCCGACACTCCC
AGCCCCACGGTCAGCGTCATCACCATCAGCAGTGACACGGACGAGGAGGAGGAACAGAAACACGCCCCCACCAGCACTGTCTCCAAGCAA
AGAAAAAACGTCATCAGCTGTGTCACAGTCCACGACTCCCCCTACTCCGACTCCTCCAGCAACACCAGCCCCTACTCCGTGCAGCAGCGT
GCTGGGCACAACAATGCCAATGCCTTTGACACCAAGGGGAGCCTGGAGAATCACTGCACGGGGAACCCCCGAACCATCATCGTGCCACCC
CTGAAAACCCAGGCCAGCGAAGTATTGGTGGAGTGTGATAGCCTGGTGCCAGTCAACACCAGTCACCACTCGTCCTCCTACAAGTCCAAG
TCCTCCAGCAACGTGACCTCCACCAGCGGTCACTCTTCAGGGAGCTCATCTGGAGCCATCACCTACCGGCAGCAGCGGCCGGGCCCCCAC
TTCCAGCAGCAGCAGCCACTCAATCTCAGCCAGGCTCAGCAGCACATCACCACGGACCGCACTGGGAGCCACCGAAGGCAGCAGGCCTAC
ATCACTCCCACCATGGCCCAGGCTCCGTACTCCTTCCCGCACAACAGCCCCAGCCACGGCACTGTGCACCCGCATCTGGCTGCAGCCGCT
GCCGCTGCCCACCTCCCCACCCAGCCCCACCTCTACACCTACACTGCGCCGGCGGCCCTGGGCTCCACCGGCACCGTGGCCCACCTGGTG
GCCTCGCAAGGCTCTGCGCGCCACACCGTGCAGCACACTGCCTACCCAGCCAGCATCGTCCACCAGGTCCCCGTGAGCATGGGCCCCCGG
GTCCTGCCCTCGCCCACCATCCACCCGAGTCAGTATCCAGCCCAATTTGCCCACCAGACCTACATCAGCGCCTCGCCAGCCTCCACCGTC
TACACTGGATACCCACTGAGCCCCGCCAAGGTCAACCAGTACCCTTACATATAAACACTGGAGGGGAGGGAGGGAGGGAGGGAGGGAGAG
AATGGCCCGAGGGAGGAGGGAGAGAAGGAGGGAGGCGCTCCTGGGACCGTGGGCGCTGGCCTTTTATACTGAAGATGCCGCACACAAACA
ATGCAAACGGGGCAGGGGCGGGGGGGGGGGGGGGGGCAGAGGGCAGGGGGACGGGTCGGGACACCAGTGAAACTTGAACCGGGAAGTGGG
AGGACGTAGAGCAGAGAAGAGAACATTTTTAAAAGGAAGGGATTAAAGAGGGTGGGAAATCTATGGTTTTTATTTTAAAAAAGAAAAAGG
AAAAAAAAAAAGTCAATAACAAAAAACCCAGCTCAAGAACCCATTCTACGCCAAACTGGAAAGGAGAAGAGAGCAACAGGAAGATTCCAG
AAACGGGGGGCCCCAGTTTTTGAAGAACTTTATGAACTTTTCAAAGATTATTTTCATATGGCAGCAAGTGATACGGAAGACTGCTGTCAG
GGACACCTGATATGGAAATCAAATAGATTTTTAATTAATTGAACATAAGATTTAGGGATTTTTCCAGAACTCGAAAGGGTCAACAGCCCT
CCAGAATGTCGGGCTGCAGCCTGAGGAGGCTGATGTTTGGAGCTGGTGTGGGATTGGCGAAGCCCAGTCCGGGCTCCCTAGTCAGGAAAG
ACGGGGGACGGCCAGGCTGCTGGAAGGCCCCCGGGGGCGCGGGGCGAGTTTTCTTTTTCTGAGCACTCTGGATAAATCCCTAAGCAACGT
TGTTTCTCAAATGTCATTAATAATGTGTGTTGCAAACTTTAGGTTTTTTTCTTTTCTGAAAATGTATTTTCTCTTTGAATCCACCCCTAG
TCGCGTAGCGTAGGGCTAGCGGTCGTCACAGACACCCTAGTAGAATGTAGCACTCAGCACCCTTGTCTCCTACCTTGTGTTCAACTCCAA
TGATACCAATAGAATATTCCTCAATGTAATTGCACAAAAAAAAGCGATATAACATAGGCATGTAACCAATGTGGCGGTGCAGGTGTGCGG
GTGAGCGAGCACGTGTGGGTGTGCACGCGCCGCCCTCCCCGCGTGGCCCTCGGCGCCGCCACCCTAGCTGGCGCAGTCTTGACACTGCAT
CCTTCCCTCCTAGTGCCTTACCGAGCGACAGACGCGGCGTGAGGGTTTACTTCCACTGGTACTCCAAGAAACTGAGGCTAGTCAGACACA
ATCTCAGCTCTTCTGTTGTGCTGTTGTAACAGTTTACGCTGGCCTTTTTTTTTTCTTTTTCTTTTTCTTTTTAAAATGTTAATGCCCGTT
GTCTTTCCTGGGCTGTTTGCTAGCGGAAGGATGCCAGGGAAGCCAGCAGGAGCTAGGAGAGAGTCCGTGGATCTCGAAAGAAATATGGGA
GACAGATGCCCGGCGGGTGCGTCTGGAGATGGGGACGGCGGGAGTTGAGTTGTGGCAGTAGTTGAGTTGTAATTTGTGGGCGGAGGCCCA
GAGAGACTCCCCACCCTTCACCCCTGCCCCACTCTGTCCCCAGTTCCGCCATTTGTGAGGCCAGAGGTTTCCGGACTGTTGGCCTCGCCA
GGCAGCCGTCTCCCGCCCCAGGCGGCATCCCCCAGTCCCTCCCGCCTCCACGAGAGCCTGGAGCTCTCAGCCTCGCCCGGGGCTCCACTC
TCTCCTCCGGCTCCCTGGGCTGTTTTGCTCTAACGATCTTGCCAGATCCCTCCCTCTGTAGACAACCACCAACCTCTGTTTGCTGTTGAA
TTCTCTCCTCACATTACCCAGGTCTGCTCAAGACATGATTTTGGTTTTGGTTTCTGAGGGTTCTAGTGGGCAGAAGGTTGGAGGGACACT
TATGAGGGTGGCCGGGGGTCTGACGCTGCACTTTGGAAAAACTCACACAGTTGAATTTCCAAAGAAATCTGCCCTTTGCCCTCTTTGCAC
CTTTGATACATTCTGGAAGTTTTCTCAGGCTTTGGACACTTCTGGGGATGGAGGTGTGGAGAAGTGGGGAGTTCCCTCTCTTCATAGTAA
ATAACTCTGAAATATGTGAATGTGAATGGCAGGAGAATCTGGCCAAGGATGGGGCCGAAAAGGGTGGTTCTAATTGTTTGCTTCTGATGT
TGAGTCTTTAGCTGACCCCACAGGCAGGTTTCCAAGGTGCAAAGAGATCTTTCCCGAGTCAGCGGCCCCATCCTCATCCTCCCTCCCTTT
ACTTCCTCACTGTGCAGTCTCCCTCAAGGATCTACTGTGAAAGGTGTGTTTGTAGTGATATCCAACCTAACTCAGTAACGAAGTCGTTAC
TTAGCTCTTAGCTGTGAAATAACTCTGGAAACTTCCCCACCCCAACCATAAATTCTTACTTATAAAGAAACAGGTCCCCAAACTGGAAAC
AGCTTAGTCCAGGCCTCAGCGAGAAGGAAGGACACCATGACTGCTCCATGCTGGGCACAGCCGGGCAGTCTTGCCAAGTGCCTGCTGGAG
GCTGTGCCGGCAAGAGGCCTGCAGCAAGGAGATTCCCTTCCCTCGGGCCATTATCAATACTGTCTTTATCTGGAGGTGGGGAAGCGCAGC
CCTCTGAGACAGCAGGACAATGGTCAGTTCAGAGAGGGTGAGGGCAGCAAACGCTTCAGAGGACACAGAAGCCAGAGGACCCCCCCCCGC
CCCACAGCTGGGTCAGCCTGGAAAATCCATCTATTAGGGACTTTTTGGCAGCCAGATGGCAGCAATAGCCCATTAGGTCTCATCCCGAGT
TCCAAGTCTTGGCTGCAAATGAGCCTCAGTTCGCCTTACTGGAGAGCACCCCCAGATTCCTGGGCACAGTTCATTTCCAGCCCTTTCTAG
ATCTGATCTTTTAGGGGGAAAGACAGCTTAAAATGTTCTTTTCATTTTAAAGAAAATTATTCTGTCTGCTTAAGTTGGAGGCTACTTACT
CTTTCACCTGACATTTTCTTTCCTTTTATTCTTCCAGATCAGGAATGAAATTTCCATGCTGCTCATAAAGATAATATTATTGTACTAATT
ATTTTTATTACCATTGTAATTATGATCATTATGTTGATATTTTAGTCAGGGTTTTAAATGCACATTTATTCCAAGTATCTTTGTGTTTTC
TCTTTAATATTTAAACTTATTCTCTCTGTGAGTATATAAGTAGACTGGAGGGACATCCAGATGTCCAGTTTTGTCAGGCAAAAAAAAAAA
GGAAAGACTTAGGAAGTAGGAAAATTGTTTCTGTCATCTCTATCCCAACAAGAGACGTCAAGAAAGATCCACCACAGAACAAAAGTTTAA
AGAAGAATCAAAGCCTTGATTGGGCTTCTGACAACATGGTCACCATCAAGGTTGTCATTTTCTAGATCCCAGAGGCCTGGGATGCGACGT
CAGGTGGCATCTCATGGGCTCGGGGAATGTCGAGTCACTGACTGTCCAGCCCTTAGCCAGCTTCTCTCCCACATCCTCAGAGCTCTCCTG
TGCTTCTGAAATCTGTTAACTAAATCTTTGGCTTGCCTCTGGTATTTAAGCAAGAAAATTCCCTCCCAGAGGTGACCCCATCCGCTTCCC
CACAATCCATCCTTTTGCCATCGGCGCACCTGGGGCGTGGCTTAGGTTCTTCAATGCAGGGACATTTGCCCCCTCCCAGAAGCTGCTGGG
CACAGTGAGGTGGCGTAAGAGTGACTGGCAGGTGGTACCTTCCCCAGGAAATTTCACCACACCACCCAGTTCCTCAGCCTGCCCCCTCCC
CCTGTGATGCATGCCCCCAGCACCCAATTCTAGCCAGCTGGAAGTGGGTGGAGGGACAGCAGGAGGCCAGAGAAACCCTGAACAAAGCTG
GGCGGCTGCTCAGGCATCACAGGCTGCACCCCCTCTGAAAGCATCCCCACTGGGCTCCGGCCACATCTTCAGTGCACTGTGCTGTGTGCG
CTGGGTGCTCACACGCTGTCCCCAGACCCACAAAGTGCTAGGCCCCAGTTGAAGAAAGGGGTGAAATAGCCAGCTTCACCGAAGGGAAGG
GAAGGGAAGTATTGGGCGATGCCAGCCCCACAGACGCTCAGCAAACATTAGTGCACATTCTCCTAGTCCTCACCCAATGGCCTCCTCTAC
CCCCATGCATGGAGCTGCCACATCAGAAGCCCCAAGAGAAGCTCCCTGCAGGAGAGGCCAGCTCCCTGGATGCCCAATTGCATACCTGGC
CGAATCTGCCATTGAGTCACCTTAGCAAATAGGCTGCTGTCACTAGGACCAAGCTCTCAAGCAGAGGGATGCCAACCTAGTCCTTACTTA
GCCCACGAATCATCTAGAGCATCCTCTAGTCTTTTGTGGGCTCCCTCCTTCCCATTTGAAGAGACATTGTTCAGAGGAAGAGGGGAAGAT
TTGAAATGTCAGGTCACGGAGGAGTGTTTAACTGGAGCCTGGTGAACCGCAGGGCAATTTGCTTCTGCTCACTGGGTTCTGACTGGCCCG
TCTGGACGTGGGCCCCCATGTCTCTGTGCTTAGGGCCTCTTCATGATGTTTTGGATGTTTCCAAGGGAAGTGGGTGAGCAGATCAAGGGG
TGGGAGAGTCGAGGCTTGATGCCAGTTAATACTGTGAAGTGGAGCGTGCGGTCAGTGGAATTCAGAGGAAAAAGAAGGGTTGGAGCAAAG
CGGCATTCATCTCCTGGACTGTTAGCCTTTCTAGTCTTCCTGGTGGCTGAGGTGTTCACGGGCTGGGGGAGCCAGCTGACCTTTGTCCTC
TTCAACCTAGAAGACTCAGCCCGCCCAGACACCAACGTGTGAGACGGATGGACATCAGGAAGGGAAGGGGAGATTAGCCCAACTGCTGAC
AGAACGATTTCCCTTGGTTGGACCTTGGGAATGGCAAACACTCATATTGGAACAAGCTTGGGGTGGAAGATTTAGGCCGTGTGAGCATGT
GTGAGTGAGTGGAACAAACTTTCTTGGAAACTGGAGGGAGGAGATGAGGAGGCTTCGGGAAGTATTACTGATGGCTCATGGTTGAGAGAG
CGACGTGGGGACCCAGCTCGCCCCAGCTTTTGTCCCAGGTTCTCTTTGTCTGATGCTGAGGGCAGGGTGGGGTGTGGGACCACCACTCTT
GTTGGCCTGTCAAGTAGACCCTAGGACAGAAAATGGAAAGAAGGAAATGGCTCGGTGCTCTCAACTAGCAGAGAGAATTGAGGAGAGGTA
AGGGTTCCTTCTGCAGGCCAGCCTGGGACTCCACAGCGCCAGCAGGAGTGACTTGGCCACAAGACATTCCAGCCCCAGGGACTTTGCAGG
CTTCATTCCCTGTCTGTGTCTTTTCCTTCTGGTGTGTTTTACAGACTTCTGATGGGGAAGCTTCAAACTTGAGCAGGCCAGAGATGTCCT
TACCAAATTGGAAAGGAAGGTGAAACTGTTCCTTTCTTTAGCCAAAGAACCCTTCTCAAAGACGCCTCCAGAAATGGACAAAATGGCCTT
CCCTTCGTTCCTTTCCAGGCAATAATGACATCATTAGTGATGCAATTCTATTTGTCTTTCTCTTTCCTCTCTGTCCTTTTTTTTAAAAAA
AAAAAATGCATTTATTTCAAAACTGTGCTATTCTTTTAAGAGGAGTGGAGGTGACCCCTTCGATGCTGCTGCTATCGGGAGACAAGGTGC
CATACCAATACGTGGGCTTGACTAATCCCAGGCCACCATGGGAGAGAGCAAAGCAGGGCTGCCAGGAGTTCAGTTGCATCAAGGGCGTAG
AGCACGCGGGGGCTGGGCTCGGAATAGCAGTACTTTTCCACTTTGATGCCTTAGAACTCTCACTTCTCATCTCCACAGACCAGACTCAGT
AAAATCTCAGGCCACTAGAGAATGGAAGGCGGTGAAACAGGATTTAAATGCAAAAAAAACCTATTGGAGGCTTTTGGCACCGTGGCTCAC
TAGAGGGACCCAGCATAGTAGAGGTTTCTCTTGTTGCAGCTTCTGAAAAGTTCAAAAAAGAACTCCAGGCCGTTCTTCCCTCAAACCCAG
TGAGAGTTTGCAGAGAAGTGCCCCCTGCAGGGCTCCCGTCCCAGAACACCAGCACCAGAGAGGGTCTTCCCGATGCCCCCCGCTGGACTT
GCCCAAGCCTCTGGGAGCCCCTCATCTCAGATCCCTGTGTTGAACATGACACTGACTGTCCCTTATTTGTTAAAATTTGCAATATCTCTC
AAGTAAATAATAGCCAACATTTGTTGAATGCTTTCATGACTCCCGGGCTAAGGCCTTTATGAGCGTTGTCTCAAGGGGCCCCAACAGCCA
TCCCACAGGGAGGGGGATAACAGCCCCCATTTATAGATAAGGGAGCTGACCGGATGCTCTGAGAAGTGGCAGGTGTTGAAGGAAGGATAA
AGCAGTGATGGGCCAGAATCCCCAAGGTTCCCTTTTTTGTTCATCAGGCCCTTCCTGAGATGTGATTTTTAATCTTTTAACTTTTTTTAA
TTAATAGCAATGCGTGGCCTCATATTTCTATGAACCATTTAGTGATACTCCCGCTTCCTGCATGCCACACACTGTGCTGGGAATTGCTCA
TGGGTTGTCCTGTTTCATCTTCTCCGTAGCCCTGTGAGATCGGCAATATTAGTCCCCCTACAGCCAAGGAAACTGCCCAGAGCCACACAA
CTCTTGAGGGGCGAGGAGGGCTTGAACCTGAGTCTGCCCAGCTCCAGAACTGAGCTTGCAGCCATTAGCCACAGCTGTCTCCTGCATGTC
TGAGCAAAGAAAGGCCTTTACACAGCATCACCCTGTGCCATCCCATGCACCGTGGGACTCAGCTAAAGGACTGTGCAAAGAGGGGGCTCC
TGAGTTGGATTTAGGCAAAAGGGGCAGAATTCGTTTGATTTTTAGAGAAAATCTCTGGAGAGTTTCTTTTGATTCATAGAATTCCTTTTA
GATTTCTTTCCAGCATACCAACTAGCTTTAGTAGTGCTGCTACAACCAGCTCTTATAAGTAAGAGTGAAAAAGTATTCTTTTCTTCTTTA
AAAAATAAGTTTTTCTTGCTTATAGTTAATTCTAGAAAGGCAATACTAAAGGTATATATTTTTTTCAAAATGCTATTTTTTACTGCACTT
GATAATTATCCTGACAGCTCTGATCTCTGTAATAGATTCACTCTTCAGCTCTGGGCAGAACCAGAGGCAGGGTTCACACCAAATTTGTAA
ATACCATATGTGGGTCTGGTGTCCAGGAACTTTTTTCTTTCTGTTAAAAAAAAGAAAAAAAAAAGAAAAAAAAAAAGAAGTAGAGGTGGA
AGAAAGACAAGACTTAGAGGAACAAAAGAATGTTTTCTTTTGAGATACTCTTCTCAAAGAAATAGCAACAATTGTATAAACAGGAAAACC
AGCCAGCTTTCATGATAAAAGGAAGGCGTGTCTCTTGCCCTGGTATGAGATTAACAGAAATACAGATGCATTTTTATTTTGATTGAAAGA
TGGTGAGAATGTAGAAATGCTTAGGACTAGATTTTTAATTTTTTAAAATAACTATTATCATTTATTATGAAATATTTGTTCAGTTGTTTT
GAGTGGGTTTCTTGTTCCTTTTTTCATTTAAAACCTTCTTTGTTGACTGGCTCCAGGCTTGTTTGCCTAAATTCTTAGGTAGTTTACACA
AGTTCTAGAATCTTTTAGAACTTTAACTCCATTGGAAGCAAACCTAACTAATCGGAGTTTGAGATCCTGGTTGGTTTCAATAGGTATTCT
GGAATTCTGGCAGAACACCTAAAGATTTTTTTTTTTTTTAGAAGGTTTTAGATACATTATCTTACACAAACTGTGACCTAATGGCAATAA
TTACCTCAAATGTGGGCATTCATCCTGGTTTTAGCCTTTTTTGAAATCATGTAGCCAGCTTGATCTTGGAATTTAAAGACTATGAATTCT
CTGTGGGCTGAAAATAATGATTACTTCATACCCCCGGTCATCGTTGCTTAAGTGAATTCTGAAAATAGCTCATCTTTACAACAAAAATTA
AACCAAGGAAGAGATTATTCTTTGTGTGTTGTACTCAAATGCGATGTTCAAATGCACATGTTAAGTATATATGTTTTTAGCTACTGTAAA
ATGCTGTTAGCCTTCTAAGCTATCAAAACAGTCACATTTTAAATGAGTAAACTAAACAATTGACTGTGGATACTTAAGCATATTTCTGGC
TACGTTTTATAGTTAAAGTGTTTTATAGTTTACATTTAGACTGGTACTTTTTAAAGAAAAGTTCTGTTTATAACTGACATCCGCAAACCC
CAGTGAATGCCTCTTAGTTGGAGGTTGTGTCTCCCCCAAGGCAAGTGTGTTGTCCCAGACTCTTCTGTAGTCCAGCATGCGCACTTCCCT
CTGGATTATTACTTTCCACGTGAACTCAAGAGAACATGAAAGGCAATCCAGATGGAGGGAAAAGGTGTGAGTCCGCAGCCCGGGCCAGAT
GCGAAGGTCTCATGCGTGTCGTCTAAACACTTGTCTTCAAGGCCTTCTCTCTGACATCTTGGAAGAGTCATTGAGAACAGATAACCTGGT
TCATTGATTTTTGTCTTGATTTGAATATTTAACTTATTAATAGATCCACTGATTTCCAGGCACCAGGCAGTAGAAGAGACTGGGATTCAG
GTGACCATGAAGGCACAGCTGCTACTTCTGGGCCGGGGGTGATATTTTGATCAGCGTTTTGTAGGGGAGGACCATATACCCCTATTCCCA
TGGTCGCTGGCTGGGTTTTCCATATATCTGCTGTCATTTATTCGTTTTCCCCTTAAAAGCAAAATCAATGTAAAAGGCTATGTTTACGTT
TTACTCATTGTCCAGCTTAGACTCAAAGTCTAGTTCGGTGGGAGGGGGACCTTAGCATCCTCTCAGAGATGGTCAGGGCTGAGCAGGAGG
AGGCAGAGACAGAGGGGCAGCTCAGCCTGGTCCATTGAGACCCACTCTAAACAGACATCATATTTGGAACAAGAAGATGCTTCGAGACAG
GAATGGGCCCCACTGTCATGCAGAAACAGACTGGGGGAATGGCAGTTTCCCTGAGTCTTGGTTTCTTTTATGTTTTCTCTTGTGCCACCA
CCAAACTGCAGAGGACCTGCTGTGACCTAAAGGGCATTCCTTTAGCAGATAAGACCTTGAAAACTGCAAAACACCTGGGACCAGGGAGCT
TTTAAAAAATACAAAAAAATACCACATTTGCTTTTTCCCTGTGAACTGTATTGACAGCGTGTTCTTAGGACAGTCTTTTGGTGGAAATGT
TACTGTAAAATAGTTTTCATCTCACCCCTCCTAATCATACTCCCACTTTCCTGTTTGTGTGGTGGTGTTGCTGTTTTTTCCTTTACATGA
ATTAACCAAATGAATTTTGTGTCATTGTTTTTGGGGCTTATATTTTTAAAACATAGAAATTGCCTTTTGTTCATTTGAAAAGTAAGTATG
TTGTATCTGAAAAAGGGCTCTGCCTCTGCTCTCCCTCGCTTCCTTGTAACCAATCTCCAAACGAATCTCTCCTGGCACCGCCCCCTTCCT
TATATAGGGTCACTGTCCCCGGGGCCACCTCTGCCTCCACCCTGCTGTCACCACTGCCCTGGGCCAAGGCACCCAGGACTCCCAGAAAGC
GCGAGAGCCAGCAAGAAGGCCCCACTCAGCCTTGAGACTGGTGGTCACACCTCCCTGTCAGAGTCGCCTGCTGGGCTGAAGGGGCAATGG
ATTGTCATTGTTGAAATTGTTTGGCTCAGGTTATAAGGAGGAACTTGGGAAGTAGAAAGTGACTTGACCATGTGCATCCTTGGTAGCTTC
CTGTAACTAACAAATGGAACAGAGAGCACACCCCCGCCCCGCCCCACCCCAAGCAGATGTTCCCGTCAGCGCTGCCCTGAGTCAGTCGGT
CCCCCGTTTCTGCTCTCCTCCCTTTTGTGTTCCTGCTCACTTCAAGCTTCTTCCATGGACTTTCCAGGGCACAGTCATCTCTAGCCCCCA
AATCATCTCTTCATCCTCTGTGTGTGCATTTTTTTAACCAAATGAAATAGACAAGAAAGTCATACTTTGGGGCAGCAGAATTTCTAATTT
AGTAGAATCACTGTATAGAGATAGATGTTGATATATATGTTTGTGTATATATATCAAACCAAATTGGATAGGAGAAGTATAGCTTTACAG
ATGAGGAGAAGGAGCTCTTTAGAGGTCGGAGTCAAGACTGGTGTCTTGGACGTGCATGGGCTGTGTCCCAGGCCACTCCGCACACATGGG
GCTGAGGCGTGGCGCCGGGCCCTTGTCATCCACCTCACCACGGCAGAGCCAGCAGGCCCTGTAGGGTGCTGCTGCTGTCTCACTGGGTCC
CAGCTTCAAGCGCATCAGTGGGTGACGGGGGCAACAAATCAGAGTGACTGGAAGTTTCCATCCCGTTTTGCTTTGACCACGTGTACTGAG
CTGCAGCCTCTGATACTCTGTCACGTTTCCAAAAATGGTATCCATTAGGATAGAAAGAGAATGGATCTGCAGAAATGTTTACCTTTCAAC
TGCTCATGAATTCAGGACACTGGATAGAAAGACTCACTCCCCAAAATGAGAACAGGGAAGAGGAGACCCGGCGACACTAAGTCACCAGGT
CCAAGGAACGTGGCTCCCTCCCCAGGGTCATCTCACCTAGATCTTTCTCTCCCAGGTCATCTCAGCTCAATCTCAATAACCCTATGAAAG
CCCTGGTCTGTTGTGTTCCTTCACCGTACGGTTTCTGTAATAAAAAGTGTTAATCCATGTTAATCTGTGTGAAAATTATTGCGTGCAACA
GTATTTTCTCGTGTACCTCTTTTTCCTATGTGAATTGTCCCTCTTTTTTATTTATAAATGTCTACTTTTGTTTTTTTAAAGACAAACCAA
TGTGTTGTAGACCTATATGTAACCTATTCCTTAGTCTCATATTATAGGTATGTTATAAGAATGGATATTTTACTTGGCTTTAGAATGTTT
TACAAGAAAACTAATTCTTAACTGATCAAGTCCTTGCTACTAAAATGCTTGTGTTTTTCATCATGACGTCGTGTGCTTCTAAATTAATCA
TTTTCGTTGTAGAAAAATGGAGTGAATTTATATTAGTCTTGGAAACTAATAATAGCATTGTAAATTTATGAGATGATTTTAACAGAAAAA
ATATAGAAGAATATAGTTATTTTAATTGTAATATTACTAACTGTAGGGTGAGAAAAAGGGGGGGGGGTCCCATTGTGGTGAACTATGTTA
TAGCTTGTTACTCATAGTTTCTTTTTGATCATTTTTTCGGTCTCCGAGGTGAAATGACTTATTAATTAAAATTTGTAAACTCACATATGC

>53289_53289_5_MFSD8-HIPK2_MFSD8_chr4_128870959_ENST00000296468_HIPK2_chr7_139305309_ENST00000406875_length(amino acids)=651AA_BP=
MEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQAPSSTSATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPL
QTGTAQICARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAWQQLTGVA
THTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTC
EVSSSQAISSPQRSKRVKENTPPRCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHAPTST
VSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSS
YKSKSSSNVTSTSGHSSGSSSGAITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSHGTVHPHL
AAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASIVHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASP

--------------------------------------------------------------
>53289_53289_6_MFSD8-HIPK2_MFSD8_chr4_128870959_ENST00000296468_HIPK2_chr7_139305309_ENST00000428878_length(transcript)=2521nt_BP=326nt
AGGTTACAAGCAGCAGATCCCACCTTCAGTCCTGGCTCTGACAAGCCCTCCAGCTTCACGCCACCCGGGATGGGAGAAAGCAGGTGTCGC
GAGAGTTGGGCGCAAGACGCCTTGTAGGGAGTGTAACTATGGCCGGCCTGCGGAACGAAAGTGAACAGGAGCCGCTCTTAGGCGACACAC
CTGGAAGCAGAGAATGGGACATTTTAGAGACTGAAGAGCATTATAAGAGCCGATGGAGATCTATTAGGATTTTATATCTTACTATGTTTC
TCAGCAGTGTAGGGTTTTCTGTAGTGATGATGTCCATATGGCCATATCTCCAAAAGCGTCAAATCATGTTTCCAGAACATGGAGATCTGC
AAGCGTCGGGTGAATATGTATGACACGGTGAACCAGAGCAAAACCCCTTTCATCACGCACGTGGCCCCCAGCACGTCCACCAACCTGACC
ATGACCTTTAACAACCAGCTGACCACTGTCCACAACCAGCCCTCAGCGGCATCCATGGCTGCAGTGGCCCAGCGGAGCATGCCCCTGCAG
ACAGGAACAGCCCAGATTTGTGCCCGGCCTGACCCGTTCCAGCAAGCTCTCATCGTGTGTCCCCCCGGCTTCCAAGGCTTGCAGGCCTCT
CCCTCTAAGCACGCTGGCTACTCGGTGCGAATGGAAAATGCAGTTCCCATCGTCACTCAAGCCCCAGGAGCTCAGCCTCTTCAGATCCAA
CCAGGTCTGCTTGCCCAGCAGGCTTGGCCAAGTGGGACCCAGCAGATCCTGCTTCCCCCAGCATGGCAGCAACTGACTGGAGTGGCCACC
CACACATCAGTGCAGCATGCCACCGTGATTCCCGAGACCATGGCAGGCACCCAGCAGCTGGCGGACTGGAGAAATACGCATGCTCACGGA
AGCCATTATAATCCCATCATGCAGCAGCCTGCACTATTGACCGGTCATGTGACCCTTCCAGCAGCACAGCCCTTAAATGTGGGTGTGGCC
CACGTGATGCGGCAGCAGCCAACCAGCACCACCTCCTCCCGGAAGAGTAAGCAGCACCAGTCATCTGTGAGAAATGTCTCCACCTGTGAG
GTGTCCTCCTCTCAGGCCATCAGCTCCCCACAGCGATCCAAGCGTGTCAAGGAGAACACACCTCCCCGCTGTGCCATGGTGCACAGTAGC
CCGGCCTGCAGCACCTCGGTCACCTGTGGGTGGGGCGACGTGGCCTCCAGCACCACCCGGGAACGGCAGCGGCAGACAATTGTCATTCCC
GACACTCCCAGCCCCACGGTCAGCGTCATCACCATCAGCAGTGACACGGACGAGGAGGAGGAACAGAAACACGCCCCCACCAGCACTGTC
TCCAAGCAAAGAAAAAACGTCATCAGCTGTGTCACAGTCCACGACTCCCCCTACTCCGACTCCTCCAGCAACACCAGCCCCTACTCCGTG
CAGCAGCGTGCTGGGCACAACAATGCCAATGCCTTTGACACCAAGGGGAGCCTGGAGAATCACTGCACGGGGAACCCCCGAACCATCATC
GTGCCACCCCTGAAAACCCAGGCCAGCGAAGTATTGGTGGAGTGTGATAGCCTGGTGCCAGTCAACACCAGTCACCACTCGTCCTCCTAC
AAGTCCAAGTCCTCCAGCAACGTGACCTCCACCAGCGGTCACTCTTCAGGGAGCTCATCTGGAGCCATCACCTACCGGCAGCAGCGGCCG
GGCCCCCACTTCCAGCAGCAGCAGCCACTCAATCTCAGCCAGGCTCAGCAGCACATCACCACGGACCGCACTGGGAGCCACCGAAGGCAG
CAGGCCTACATCACTCCCACCATGGCCCAGGCTCCGTACTCCTTCCCGCACAACAGCCCCAGCCACGGCACTGTGCACCCGCATCTGGCT
GCAGCCGCTGCCGCTGCCCACCTCCCCACCCAGCCCCACCTCTACACCTACACTGCGCCGGCGGCCCTGGGCTCCACCGGCACCGTGGCC
CACCTGGTGGCCTCGCAAGGCTCTGCGCGCCACACCGTGCAGCACACTGCCTACCCAGCCAGCATCGTCCACCAGGTCCCCGTGAGCATG
GGCCCCCGGGTCCTGCCCTCGCCCACCATCCACCCGAGTCAGTATCCAGCCCAATTTGCCCACCAGACCTACATCAGCGCCTCGCCAGCC
TCCACCGTCTACACTGGATACCCACTGAGCCCCGCCAAGGTCAACCAGTACCCTTACATATAAACACTGGAGGGGAGGGAGGGAGGGAGG
GAGGGAGAGAATGGCCCGAGGGAGGAGGGAGAGAAGGAGGGAGGCGCTCCTGGGACCGTGGGCGCTGGCCTTTTATACTGAAGATGCCGC
ACACAAACAATGCAAACGGGGCAGGGGCGGGGGGGGGGGGGGGGGCAGAGGGCAGGGGGACGGGTCGGGACACCAGTGAAACTTGAACCG
GGAAGTGGGAGGACGTAGAGCAGAGAAGAGAACATTTTTAAAAGGAAGGGATTAAAGAGGGTGGGAAATCTATGGTTTTTATTTTAAAAA

>53289_53289_6_MFSD8-HIPK2_MFSD8_chr4_128870959_ENST00000296468_HIPK2_chr7_139305309_ENST00000428878_length(amino acids)=624AA_BP=
MEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPPGFQG
LQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAWQQLTGVATHTSVQHATVIPETMAGTQQLADWRNT
HAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPPRCAM
VHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTS
PYSVQQRAGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGAITYR
QQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSHGTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGST

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MFSD8-HIPK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneHIPK2chr4:128870958chr7:139305309ENST00000406875515935_1049539.66666666666661199.0AXIN1
TgeneHIPK2chr4:128870958chr7:139305309ENST00000428878515935_1049539.66666666666661172.0AXIN1
TgeneHIPK2chr4:128870959chr7:139305309ENST00000406875515935_1049539.66666666666661199.0AXIN1
TgeneHIPK2chr4:128870959chr7:139305309ENST00000428878515935_1049539.66666666666661172.0AXIN1
TgeneHIPK2chr4:128870958chr7:139305309ENST00000406875515774_876539.66666666666661199.0CTBP1
TgeneHIPK2chr4:128870958chr7:139305309ENST00000428878515774_876539.66666666666661172.0CTBP1
TgeneHIPK2chr4:128870959chr7:139305309ENST00000406875515774_876539.66666666666661199.0CTBP1
TgeneHIPK2chr4:128870959chr7:139305309ENST00000428878515774_876539.66666666666661172.0CTBP1
TgeneHIPK2chr4:128870958chr7:139305309ENST00000406875515787_897539.66666666666661199.0HMGA1
TgeneHIPK2chr4:128870958chr7:139305309ENST00000428878515787_897539.66666666666661172.0HMGA1
TgeneHIPK2chr4:128870959chr7:139305309ENST00000406875515787_897539.66666666666661199.0HMGA1
TgeneHIPK2chr4:128870959chr7:139305309ENST00000428878515787_897539.66666666666661172.0HMGA1
TgeneHIPK2chr4:128870958chr7:139305309ENST00000406875515752_897539.66666666666661199.0POU4F1
TgeneHIPK2chr4:128870958chr7:139305309ENST00000428878515752_897539.66666666666661172.0POU4F1
TgeneHIPK2chr4:128870959chr7:139305309ENST00000406875515752_897539.66666666666661199.0POU4F1
TgeneHIPK2chr4:128870959chr7:139305309ENST00000428878515752_897539.66666666666661172.0POU4F1
TgeneHIPK2chr4:128870958chr7:139305309ENST00000406875515539_844539.66666666666661199.0SKI and SMAD1
TgeneHIPK2chr4:128870958chr7:139305309ENST00000428878515539_844539.66666666666661172.0SKI and SMAD1
TgeneHIPK2chr4:128870959chr7:139305309ENST00000406875515539_844539.66666666666661199.0SKI and SMAD1
TgeneHIPK2chr4:128870959chr7:139305309ENST00000428878515539_844539.66666666666661172.0SKI and SMAD1
TgeneHIPK2chr4:128870958chr7:139305309ENST00000406875515846_941539.66666666666661199.0TP53 and TP73
TgeneHIPK2chr4:128870958chr7:139305309ENST00000428878515846_941539.66666666666661172.0TP53 and TP73
TgeneHIPK2chr4:128870959chr7:139305309ENST00000406875515846_941539.66666666666661199.0TP53 and TP73
TgeneHIPK2chr4:128870959chr7:139305309ENST00000428878515846_941539.66666666666661172.0TP53 and TP73
TgeneHIPK2chr4:128870958chr7:139305309ENST00000406875515873_907539.66666666666661199.0UBE2I
TgeneHIPK2chr4:128870958chr7:139305309ENST00000428878515873_907539.66666666666661172.0UBE2I
TgeneHIPK2chr4:128870959chr7:139305309ENST00000406875515873_907539.66666666666661199.0UBE2I
TgeneHIPK2chr4:128870959chr7:139305309ENST00000428878515873_907539.66666666666661172.0UBE2I


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneHIPK2chr4:128870958chr7:139305309ENST00000406875515189_520539.66666666666661199.0DAXX
TgeneHIPK2chr4:128870958chr7:139305309ENST00000428878515189_520539.66666666666661172.0DAXX
TgeneHIPK2chr4:128870959chr7:139305309ENST00000406875515189_520539.66666666666661199.0DAXX
TgeneHIPK2chr4:128870959chr7:139305309ENST00000428878515189_520539.66666666666661172.0DAXX


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for MFSD8-HIPK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for MFSD8-HIPK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource