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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MGAT1-FLT4 (FusionGDB2 ID:53310)

Fusion Gene Summary for MGAT1-FLT4

check button Fusion gene summary
Fusion gene informationFusion gene name: MGAT1-FLT4
Fusion gene ID: 53310
HgeneTgene
Gene symbol

MGAT1

FLT4

Gene ID

116255

2324

Gene namemonoacylglycerol O-acyltransferase 1fms related receptor tyrosine kinase 4
SynonymsDGAT2L|DGAT2L1|MGAT1CHTD7|FLT-4|FLT41|LMPH1A|LMPHM1|PCL|VEGFR-3|VEGFR3
Cytomap

2q36.1

5q35.3

Type of geneprotein-codingprotein-coding
Description2-acylglycerol O-acyltransferase 1acyl-CoA:monoacylglycerol acyltransferase 1diacylglycerol O-acyltransferase 2 like 1diacylglycerol O-acyltransferase candidate 2diacylglycerol acyltransferase 2-like protein 1hDC2vascular endothelial growth factor receptor 3Feline McDonough Sarcoma (FMS)-like tyrosine kinase 4VEGF receptor-3fms related tyrosine kinase 4fms-like tyrosine kinase 4primary congenital lymphedematyrosine-protein kinase receptor FLT4
Modification date2020031320200313
UniProtAcc

P26572

P35916

Ensembl transtripts involved in fusion geneENST00000307826, ENST00000333055, 
ENST00000393340, ENST00000446023, 
ENST00000427865, ENST00000506708, 
ENST00000261937, ENST00000393347, 
ENST00000502649, ENST00000424276, 
Fusion gene scores* DoF score3 X 6 X 2=365 X 4 X 3=60
# samples 45
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MGAT1 [Title/Abstract] AND FLT4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMGAT1(180235648)-FLT4(180058778), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFLT4

GO:0018108

peptidyl-tyrosine phosphorylation

7898938

TgeneFLT4

GO:0035924

cellular response to vascular endothelial growth factor stimulus

9435229

TgeneFLT4

GO:0038084

vascular endothelial growth factor signaling pathway

23878260

TgeneFLT4

GO:0046777

protein autophosphorylation

7675451|9435229|23878260

TgeneFLT4

GO:0048010

vascular endothelial growth factor receptor signaling pathway

9012504


check buttonFusion gene breakpoints across MGAT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FLT4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-1804-01AMGAT1chr5

180229680

-FLT4chr5

180058778

-
ChimerDB4GBMTCGA-06-1804-01AMGAT1chr5

180235502

-FLT4chr5

180058778

-
ChimerDB4GBMTCGA-06-1804-01AMGAT1chr5

180235648

-FLT4chr5

180058778

-


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Fusion Gene ORF analysis for MGAT1-FLT4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000307826ENST00000261937MGAT1chr5

180229680

-FLT4chr5

180058778

-
5UTR-3CDSENST00000307826ENST00000393347MGAT1chr5

180229680

-FLT4chr5

180058778

-
5UTR-3CDSENST00000307826ENST00000502649MGAT1chr5

180229680

-FLT4chr5

180058778

-
5UTR-3CDSENST00000333055ENST00000261937MGAT1chr5

180235648

-FLT4chr5

180058778

-
5UTR-3CDSENST00000333055ENST00000393347MGAT1chr5

180235648

-FLT4chr5

180058778

-
5UTR-3CDSENST00000333055ENST00000502649MGAT1chr5

180235648

-FLT4chr5

180058778

-
5UTR-3CDSENST00000393340ENST00000261937MGAT1chr5

180235648

-FLT4chr5

180058778

-
5UTR-3CDSENST00000393340ENST00000393347MGAT1chr5

180235648

-FLT4chr5

180058778

-
5UTR-3CDSENST00000393340ENST00000502649MGAT1chr5

180235648

-FLT4chr5

180058778

-
5UTR-3CDSENST00000446023ENST00000261937MGAT1chr5

180235648

-FLT4chr5

180058778

-
5UTR-3CDSENST00000446023ENST00000393347MGAT1chr5

180235648

-FLT4chr5

180058778

-
5UTR-3CDSENST00000446023ENST00000502649MGAT1chr5

180235648

-FLT4chr5

180058778

-
5UTR-5UTRENST00000307826ENST00000424276MGAT1chr5

180229680

-FLT4chr5

180058778

-
5UTR-5UTRENST00000333055ENST00000424276MGAT1chr5

180235648

-FLT4chr5

180058778

-
5UTR-5UTRENST00000393340ENST00000424276MGAT1chr5

180235648

-FLT4chr5

180058778

-
5UTR-5UTRENST00000446023ENST00000424276MGAT1chr5

180235648

-FLT4chr5

180058778

-
intron-3CDSENST00000307826ENST00000261937MGAT1chr5

180235502

-FLT4chr5

180058778

-
intron-3CDSENST00000307826ENST00000261937MGAT1chr5

180235648

-FLT4chr5

180058778

-
intron-3CDSENST00000307826ENST00000393347MGAT1chr5

180235502

-FLT4chr5

180058778

-
intron-3CDSENST00000307826ENST00000393347MGAT1chr5

180235648

-FLT4chr5

180058778

-
intron-3CDSENST00000307826ENST00000502649MGAT1chr5

180235502

-FLT4chr5

180058778

-
intron-3CDSENST00000307826ENST00000502649MGAT1chr5

180235648

-FLT4chr5

180058778

-
intron-3CDSENST00000333055ENST00000261937MGAT1chr5

180229680

-FLT4chr5

180058778

-
intron-3CDSENST00000333055ENST00000261937MGAT1chr5

180235502

-FLT4chr5

180058778

-
intron-3CDSENST00000333055ENST00000393347MGAT1chr5

180229680

-FLT4chr5

180058778

-
intron-3CDSENST00000333055ENST00000393347MGAT1chr5

180235502

-FLT4chr5

180058778

-
intron-3CDSENST00000333055ENST00000502649MGAT1chr5

180229680

-FLT4chr5

180058778

-
intron-3CDSENST00000333055ENST00000502649MGAT1chr5

180235502

-FLT4chr5

180058778

-
intron-3CDSENST00000393340ENST00000261937MGAT1chr5

180229680

-FLT4chr5

180058778

-
intron-3CDSENST00000393340ENST00000261937MGAT1chr5

180235502

-FLT4chr5

180058778

-
intron-3CDSENST00000393340ENST00000393347MGAT1chr5

180229680

-FLT4chr5

180058778

-
intron-3CDSENST00000393340ENST00000393347MGAT1chr5

180235502

-FLT4chr5

180058778

-
intron-3CDSENST00000393340ENST00000502649MGAT1chr5

180229680

-FLT4chr5

180058778

-
intron-3CDSENST00000393340ENST00000502649MGAT1chr5

180235502

-FLT4chr5

180058778

-
intron-3CDSENST00000427865ENST00000261937MGAT1chr5

180229680

-FLT4chr5

180058778

-
intron-3CDSENST00000427865ENST00000261937MGAT1chr5

180235502

-FLT4chr5

180058778

-
intron-3CDSENST00000427865ENST00000261937MGAT1chr5

180235648

-FLT4chr5

180058778

-
intron-3CDSENST00000427865ENST00000393347MGAT1chr5

180229680

-FLT4chr5

180058778

-
intron-3CDSENST00000427865ENST00000393347MGAT1chr5

180235502

-FLT4chr5

180058778

-
intron-3CDSENST00000427865ENST00000393347MGAT1chr5

180235648

-FLT4chr5

180058778

-
intron-3CDSENST00000427865ENST00000502649MGAT1chr5

180229680

-FLT4chr5

180058778

-
intron-3CDSENST00000427865ENST00000502649MGAT1chr5

180235502

-FLT4chr5

180058778

-
intron-3CDSENST00000427865ENST00000502649MGAT1chr5

180235648

-FLT4chr5

180058778

-
intron-3CDSENST00000446023ENST00000261937MGAT1chr5

180229680

-FLT4chr5

180058778

-
intron-3CDSENST00000446023ENST00000261937MGAT1chr5

180235502

-FLT4chr5

180058778

-
intron-3CDSENST00000446023ENST00000393347MGAT1chr5

180229680

-FLT4chr5

180058778

-
intron-3CDSENST00000446023ENST00000393347MGAT1chr5

180235502

-FLT4chr5

180058778

-
intron-3CDSENST00000446023ENST00000502649MGAT1chr5

180229680

-FLT4chr5

180058778

-
intron-3CDSENST00000446023ENST00000502649MGAT1chr5

180235502

-FLT4chr5

180058778

-
intron-3CDSENST00000506708ENST00000261937MGAT1chr5

180229680

-FLT4chr5

180058778

-
intron-3CDSENST00000506708ENST00000261937MGAT1chr5

180235502

-FLT4chr5

180058778

-
intron-3CDSENST00000506708ENST00000261937MGAT1chr5

180235648

-FLT4chr5

180058778

-
intron-3CDSENST00000506708ENST00000393347MGAT1chr5

180229680

-FLT4chr5

180058778

-
intron-3CDSENST00000506708ENST00000393347MGAT1chr5

180235502

-FLT4chr5

180058778

-
intron-3CDSENST00000506708ENST00000393347MGAT1chr5

180235648

-FLT4chr5

180058778

-
intron-3CDSENST00000506708ENST00000502649MGAT1chr5

180229680

-FLT4chr5

180058778

-
intron-3CDSENST00000506708ENST00000502649MGAT1chr5

180235502

-FLT4chr5

180058778

-
intron-3CDSENST00000506708ENST00000502649MGAT1chr5

180235648

-FLT4chr5

180058778

-
intron-5UTRENST00000307826ENST00000424276MGAT1chr5

180235502

-FLT4chr5

180058778

-
intron-5UTRENST00000307826ENST00000424276MGAT1chr5

180235648

-FLT4chr5

180058778

-
intron-5UTRENST00000333055ENST00000424276MGAT1chr5

180229680

-FLT4chr5

180058778

-
intron-5UTRENST00000333055ENST00000424276MGAT1chr5

180235502

-FLT4chr5

180058778

-
intron-5UTRENST00000393340ENST00000424276MGAT1chr5

180229680

-FLT4chr5

180058778

-
intron-5UTRENST00000393340ENST00000424276MGAT1chr5

180235502

-FLT4chr5

180058778

-
intron-5UTRENST00000427865ENST00000424276MGAT1chr5

180229680

-FLT4chr5

180058778

-
intron-5UTRENST00000427865ENST00000424276MGAT1chr5

180235502

-FLT4chr5

180058778

-
intron-5UTRENST00000427865ENST00000424276MGAT1chr5

180235648

-FLT4chr5

180058778

-
intron-5UTRENST00000446023ENST00000424276MGAT1chr5

180229680

-FLT4chr5

180058778

-
intron-5UTRENST00000446023ENST00000424276MGAT1chr5

180235502

-FLT4chr5

180058778

-
intron-5UTRENST00000506708ENST00000424276MGAT1chr5

180229680

-FLT4chr5

180058778

-
intron-5UTRENST00000506708ENST00000424276MGAT1chr5

180235502

-FLT4chr5

180058778

-
intron-5UTRENST00000506708ENST00000424276MGAT1chr5

180235648

-FLT4chr5

180058778

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MGAT1-FLT4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MGAT1-FLT4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:180235648/:180058778)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MGAT1

P26572

FLT4

P35916

FUNCTION: Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans. {ECO:0000269|PubMed:1702225}.FUNCTION: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:11532940, ECO:0000269|PubMed:15102829, ECO:0000269|PubMed:15474514, ECO:0000269|PubMed:16076871, ECO:0000269|PubMed:16452200, ECO:0000269|PubMed:17210781, ECO:0000269|PubMed:19610651, ECO:0000269|PubMed:19779139, ECO:0000269|PubMed:20224550, ECO:0000269|PubMed:20431062, ECO:0000269|PubMed:20445537, ECO:0000269|PubMed:21273538, ECO:0000269|PubMed:7675451, ECO:0000269|PubMed:8700872, ECO:0000269|PubMed:9435229}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MGAT1-FLT4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MGAT1-FLT4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MGAT1-FLT4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MGAT1-FLT4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource