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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MGAT5-OLA1 (FusionGDB2 ID:53358)

Fusion Gene Summary for MGAT5-OLA1

Fusion gene summary

Fusion gene information	Fusion gene name: MGAT5-OLA1
	Fusion gene ID: 53358
		Hgene	Tgene
	Gene symbol	MGAT5	OLA1
	Gene ID	4249	29789
	Gene name	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Obg like ATPase 1
	Synonyms	GNT-V\|GNT-VA\|MGAT5A\|glcNAc-T V	DOC45\|GBP45\|GTBP9\|GTPBP9\|PTD004
	Cytomap	2q21.2-q21.3	2q31.1
	Type of gene	protein-coding	protein-coding
	Description	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase AN-acetylglucosaminyl-transferase Valpha-mannoside beta-1,6-N-acetylglucosaminyltransferasealpha-mannoside beta-1,6-N-acetylglucosaminyltransferase Vmannoside acetylglucosaminyltran	obg-like ATPase 1DNA damage-regulated overexpressed in cancer 45 proteinGTP-binding protein 9 (putative)GTP-binding protein PTD004homologous yeast-44.2 protein
	Modification date	20200313	20200313
	UniProtAcc	Q09328	.
	Ensembl transtripts involved in fusion gene	ENST00000281923, ENST00000409645, ENST00000468758,	ENST00000344357, ENST00000409546, ENST00000428402, ENST00000392560, ENST00000284719,
Fusion gene scores	* DoF score	11 X 12 X 3=396	14 X 8 X 7=784
	# samples	14	14
	** MAII score	log2(14/396*10)=-1.50007360313464 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(14/784*10)=-2.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MGAT5 [Title/Abstract] AND OLA1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MGAT5(135028121)-OLA1(175006728), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MGAT5	GO:0006487	protein N-linked glycosylation	24846175
Hgene	MGAT5	GO:0018279	protein N-linked glycosylation via asparagine	10395745\|30140003
Hgene	MGAT5	GO:0030335	positive regulation of cell migration	24846175
Hgene	MGAT5	GO:1903614	negative regulation of protein tyrosine phosphatase activity	24846175
Hgene	MGAT5	GO:1904894	positive regulation of STAT cascade	24846175
Tgene	OLA1	GO:0046034	ATP metabolic process	17430889

Fusion gene breakpoints across MGAT5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across OLA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-61-2000	MGAT5	chr2	135028121	+	OLA1	chr2	175006728	-

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Fusion Gene ORF analysis for MGAT5-OLA1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000281923	ENST00000344357	MGAT5	chr2	135028121	+	OLA1	chr2	175006728	-
5CDS-5UTR	ENST00000281923	ENST00000409546	MGAT5	chr2	135028121	+	OLA1	chr2	175006728	-
5CDS-5UTR	ENST00000281923	ENST00000428402	MGAT5	chr2	135028121	+	OLA1	chr2	175006728	-
5CDS-5UTR	ENST00000409645	ENST00000344357	MGAT5	chr2	135028121	+	OLA1	chr2	175006728	-
5CDS-5UTR	ENST00000409645	ENST00000409546	MGAT5	chr2	135028121	+	OLA1	chr2	175006728	-
5CDS-5UTR	ENST00000409645	ENST00000428402	MGAT5	chr2	135028121	+	OLA1	chr2	175006728	-
5CDS-intron	ENST00000281923	ENST00000392560	MGAT5	chr2	135028121	+	OLA1	chr2	175006728	-
5CDS-intron	ENST00000409645	ENST00000392560	MGAT5	chr2	135028121	+	OLA1	chr2	175006728	-
In-frame	ENST00000281923	ENST00000284719	MGAT5	chr2	135028121	+	OLA1	chr2	175006728	-
In-frame	ENST00000409645	ENST00000284719	MGAT5	chr2	135028121	+	OLA1	chr2	175006728	-
intron-3CDS	ENST00000468758	ENST00000284719	MGAT5	chr2	135028121	+	OLA1	chr2	175006728	-
intron-5UTR	ENST00000468758	ENST00000344357	MGAT5	chr2	135028121	+	OLA1	chr2	175006728	-
intron-5UTR	ENST00000468758	ENST00000409546	MGAT5	chr2	135028121	+	OLA1	chr2	175006728	-
intron-5UTR	ENST00000468758	ENST00000428402	MGAT5	chr2	135028121	+	OLA1	chr2	175006728	-
intron-intron	ENST00000468758	ENST00000392560	MGAT5	chr2	135028121	+	OLA1	chr2	175006728	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000409645

MGAT5

chr2

135028121

ENST00000284719

OLA1

chr2

175006728

4455

658

252

1475

407

ENST00000281923

MGAT5

chr2

135028121

ENST00000284719

OLA1

chr2

175006728

4348

551

145

1368

407

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000409645	ENST00000284719	MGAT5	chr2	135028121	+	OLA1	chr2	175006728	-	0.000367611	0.99963236
ENST00000281923	ENST00000284719	MGAT5	chr2	135028121	+	OLA1	chr2	175006728	-	0.000359309	0.9996407

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Fusion Genomic Features for MGAT5-OLA1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MGAT5-OLA1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:135028121/chr2:175006728)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MGAT5 Q09328	.
FUNCTION: Catalyzes the addition of N-acetylglucosamine (GlcNAc) in beta 1-6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides (PubMed:10395745, PubMed:30140003). Catalyzes an important step in the biosynthesis of branched, complex-type N-glycans, such as those found on EGFR, TGFR (TGF-beta receptor) and CDH2 (PubMed:10395745, PubMed:22614033, PubMed:30140003). Via its role in the biosynthesis of complex N-glycans, plays an important role in the activation of cellular signaling pathways, reorganization of the actin cytoskeleton, cell-cell adhesion and cell migration. MGAT5-dependent EGFR N-glycosylation enhances the interaction between EGFR and LGALS3 and thereby prevents rapid EGFR endocytosis and prolongs EGFR signaling. Required for efficient interaction between TGFB1 and its receptor. Enhances activation of intracellular signaling pathways by several types of growth factors, including FGF2, PDGF, IGF, TGFB1 and EGF. MGAT5-dependent CDH2 N-glycosylation inhibits CDH2-mediated homotypic cell-cell adhesion and contributes to the regulation of downstream signaling pathways. Promotes cell migration. Contributes to the regulation of the inflammatory response. MGAT5-dependent TCR N-glycosylation enhances the interaction between TCR and LGALS3, limits agonist-induced TCR clustering, and thereby dampens TCR-mediated responses to antigens. Required for normal leukocyte evasation and accumulation at sites of inflammation (By similarity). Inhibits attachment of monocytes to the vascular endothelium and subsequent monocyte diapedesis (PubMed:22614033). {ECO:0000250\|UniProtKB:Q8R4G6, ECO:0000269\|PubMed:10395745, ECO:0000269\|PubMed:22614033, ECO:0000269\|PubMed:30140003}.; FUNCTION: [Secreted alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A]: Promotes proliferation of umbilical vein endothelial cells and angiogenesis, at least in part by promoting the release of the growth factor FGF2 from the extracellular matrix. {ECO:0000269\|PubMed:11872751}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MGAT5

chr2:135028121

chr2:175006728

ENST00000281923

1_13

135

742.0

Topological domain

Cytoplasmic

Hgene

MGAT5

chr2:135028121

chr2:175006728

ENST00000409645

1_13

135

742.0

Topological domain

Cytoplasmic

Hgene

MGAT5

chr2:135028121

chr2:175006728

ENST00000281923

14_30

135

742.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

MGAT5

chr2:135028121

chr2:175006728

ENST00000409645

14_30

135

742.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

OLA1

chr2:135028121

chr2:175006728

ENST00000284719

304_387

124

397.0

Domain

TGS

Tgene

OLA1

chr2:135028121

chr2:175006728

ENST00000344357

23_283

239.0

Domain

OBG-type G

Tgene

OLA1

chr2:135028121

chr2:175006728

ENST00000344357

304_387

239.0

Domain

TGS

Tgene

OLA1

chr2:135028121

chr2:175006728

ENST00000428402

304_387

124

279.0

Domain

TGS

Tgene

OLA1

chr2:135028121

chr2:175006728

ENST00000284719

267_274

124

397.0

Motif

Nuclear export signal

Tgene

OLA1

chr2:135028121

chr2:175006728

ENST00000344357

267_274

239.0

Motif

Nuclear export signal

Tgene

OLA1

chr2:135028121

chr2:175006728

ENST00000428402

267_274

124

279.0

Motif

Nuclear export signal

Tgene

OLA1

chr2:135028121

chr2:175006728

ENST00000344357

32_37

239.0

Nucleotide binding

ATP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MGAT5

chr2:135028121

chr2:175006728

ENST00000281923

213_741

135

742.0

Region

Sufficient for catalytic activity

Hgene

MGAT5

chr2:135028121

chr2:175006728

ENST00000281923

264_269

135

742.0

Region

Important for activity in FGF2 release

Hgene

MGAT5

chr2:135028121

chr2:175006728

ENST00000281923

378_379

135

742.0

Region

Substrate binding

Hgene

MGAT5

chr2:135028121

chr2:175006728

ENST00000409645

213_741

135

742.0

Region

Sufficient for catalytic activity

Hgene

MGAT5

chr2:135028121

chr2:175006728

ENST00000409645

264_269

135

742.0

Region

Important for activity in FGF2 release

Hgene

MGAT5

chr2:135028121

chr2:175006728

ENST00000409645

378_379

135

742.0

Region

Substrate binding

Hgene

MGAT5

chr2:135028121

chr2:175006728

ENST00000281923

31_741

135

742.0

Topological domain

Lumenal

Hgene

MGAT5

chr2:135028121

chr2:175006728

ENST00000409645

31_741

135

742.0

Topological domain

Lumenal

Tgene

OLA1

chr2:135028121

chr2:175006728

ENST00000284719

23_283

124

397.0

Domain

OBG-type G

Tgene

OLA1

chr2:135028121

chr2:175006728

ENST00000428402

23_283

124

279.0

Domain

OBG-type G

Tgene

OLA1

chr2:135028121

chr2:175006728

ENST00000284719

32_37

124

397.0

Nucleotide binding

ATP

Tgene

OLA1

chr2:135028121

chr2:175006728

ENST00000428402

32_37

124

279.0

Nucleotide binding

ATP

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Fusion Gene Sequence for MGAT5-OLA1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>53358_53358_1_MGAT5-OLA1_MGAT5_chr2_135028121_ENST00000281923_OLA1_chr2_175006728_ENST00000284719_length(transcript)=4348nt_BP=551nt
CAGCAGAATGGAAGTGAGGAAAGGCAACCAGCTGACACAGGAGCCAGAGTGAGACCAGCAGACTCTCACACTCAACCTACACCATGAATT
TGTGTCTATCTTCTACGCGTTAAGAGCCAAGGACAGGTGAAGTTGCCAGAGAGCAATGGCTCTCTTCACTCCGTGGAAGTTGTCCTCTCA
GAAGCTGGGCTTTTTCCTGGTGACTTTTGGCTTCATTTGGGGTATGATGCTTCTGCACTTTACCATCCAGCAGCGAACTCAGCCTGAAAG
CAGCTCCATGCTGCGCGAGCAGATCCTGGACCTCAGCAAAAGGTACATCAAGGCACTGGCAGAAGAAAACAGGAATGTGGTGGATGGGCC
ATACGCTGGAGTCATGACAGCTTATGATCTGAAGAAAACCCTTGCTGTGTTATTAGATAACATTTTGCAGCGCATTGGCAAGTTGGAGTC
GAAGGTGGACAATCTTGTTGTCAATGGCACCGGAACAAACTCAACCAACTCCACTACAGCTGTTCCCAGCTTGGTTGCACTTGAGAAAAT
TAATGTGGCAGGTGCTTTTGAAGATGATGATATCACGCACGTTGAAGGAAGTGTAGATCCTATTCGAGATATAGAAATAATACATGAAGA
GCTTCAGCTTAAAGATGAGGAAATGATTGGGCCCATTATAGATAAACTAGAAAAGGTGGCTGTGAGAGGAGGAGATAAAAAACTAAAACC
TGAATATGATATAATGTGCAAAGTAAAATCCTGGGTTATAGATCAAAAGAAACCTGTTCGCTTCTATCATGATTGGAATGACAAAGAGAT
TGAAGTGTTGAATAAACACTTATTTTTGACTTCAAAACCAATGGTCTACTTGGTTAATCTTTCTGAAAAAGACTACATTAGAAAGAAAAA
CAAATGGTTGATAAAAATTAAAGAGTGGGTGGACAAGTATGACCCAGGTGCTTTGGTCATTCCTTTTAGTGGGGCCTTGGAACTCAAGTT
GCAAGAATTGAGTGCTGAGGAGAGACAGAAGTATCTGGAAGCGAACATGACACAAAGTGCTTTGCCAAAGATCATTAAGGCTGGGTTTGC
AGCACTCCAACTAGAATACTTTTTCACTGCAGGCCCAGATGAAGTGCGTGCATGGACCATCAGGAAAGGGACTAAGGCTCCTCAGGCTGC
AGGAAAGATTCACACAGATTTTGAAAAGGGATTCATTATGGCTGAAGTAATGAAATACGAAGATTTTAAAGAGGAAGGTTCTGAAAATGC
AGTCAAGGCTGCTGGAAAGTACAGACAACAAGGCAGAAATTATATTGTTGAAGATGGAGATATTATCTTCTTCAAATTTAACACACCTCA
ACAACCGAAGAAGAAATAAAATTTAGTTATTGCTCAGATAAACATACAACTTCCAAAAGGCATCTGATTTTTAAAAAATTAAAATTTCTG
AAAACCAATGCGACAAATAAAGTTGGGGAGATGGGAATCTTTGACAAACAAATTATTTTTATTTGTTTTAAAATTAAAATACTGTGTACC
CCCCCCCCCCCATGAAATGCAGGTTCACTAAATGTGAACAGCTTTGCTTTTCACGTGATTAAGACCCTACTCCAAATTGTAGAAGCTTTT
CAGGAACCATATTACTCTCATGATACTTCATTAATCTCCATCATGTATGCCAAGCCTGACACATTTGACAGTGAGGACAATGTGGCTTGC
TCCTTTTTGAATCTACAGATAATGCATGTTTTACAGTACTCCAGATGTCTACACTCAATAAAACATTTGACAAAACCAGCCTTGGTGTGT
TTGGGGATGTCTGTATTGACTGACTGTGGTGTGCTGAATGCGATACGGCACCTGGTGGTTGCTGATTACAGAATTTTAAGGCGTGTGTAT
GACACAGTAACTGGCAGTGTGGGGCAGCTGCAATTGTATCTTAAAAGTGAGTCTTTCATGGGAATCAGAAGAATAGTATACCAGGGATTT
GTCTCAAAAAAGTTAATTAATTTATAGATCAACATTTATTGAAAGATGATAGCAATGATATTATGAGGGATATGAGATAGGTGACTGACC
ACAAAGAAGAAAATTCTGTCTCAAAAATTAAAGAATTTTGTTTGTTATTGTTGTTCTGACCATATTGAAAAGAGGTTCACTTTTAATCTT
TCCTTTGAAATTATTAAATTGTAAAAACTGACCCATTGATGTCTGGTGGGTTATGTTTTGCTTCAATTCAGCAATGTGTATAAAAGTTCC
TACACTGATTTTGAAATACTAAGATCAGACTTTGAAAATTTTAAAAATTCTTTCATTCTTACTTTTCAGATATTTGAGAGCAGTCGAAGT
GGTAGTATGGGTAAGTTAAGCACTTCTTAACATTGTAGCAGAAAATTCCAAAAGAAAGACTAGAACAAATTGGTAATTTGGAGACCCTTT
GCCACTTAGCCTTCTCTTGTGATGATGGCCTGAAAGCTCTCTCGGCCCTGAGCCTCCCTTTCTCTCCCATGTTTCCATTCCTGTGAGACC
TCCCTTCCTTGTCCTTGTCCTCTGCCCTTTTGTGCTCTTCTGTGATCACAGGACCATTTCCATGGAATGCAGATTCATACCCAGCCAGCC
TTTGCCTCTACTGTATCGCTTTGGGACTTTAAAGATGCAGAAGTATTAGAACACACACAAACTTAAAATGGAAAGTTACCAAATGTAGCA
CTAGAGGCAAGAAAAGGGGTGATTTTTTAAAGATTTGGCTATACTTAAGATATTTAAAGAGGATGAGGTTGAGTCGTGAGTATAATTTAG
AAGCTCTCCAGTGAGTATTTTTTTAGTATCAAATAGTGATCTTCTTTTGCTAACATAAAAATGAGTAAACTACAGCAGAGAAATAAGAAT
AAAACTAATGAAGGGTTTTTTAAAAGAACTAAATAAAACAAATAAAACTAGGCTACAGGTATAGCTGACCAAGTTTGCTGTGAAAAATCC
TTGTTATATCTATTTCTGTATTGGAGTAATGTGTAGATTAGTGGATTGTTAGGGATTTCAGCAGTATAAGAAAGAATCAAATATCTTGCT
TTTGGGTCTTCTCCAAAGTAAATTGCATGGACTTCTTAAAGAAGTTTGAAATCAGTAAAAAGACATTAGGATCATGCAATTTTACTTTGT
CTAGCTTCTAATGTGGTAAATTGCACATTGTGCAACAGAACCATTAATAAAAGAAAGGAGTTAGTTTTGAGGTAACTGCATTCATTAGGG
GCTGAAAATAAATGTTAAAAATGTTTAATTTGGTTAGAAGTTCTACAACATTGTATGTACATATACAAAATTTCATTTTCTCTGAAAGTC
GAGAATTCCAAGAACTGTTACATATAATCATATATATGCCTATATCTAAACGTTTTCCCTCCTTTAATATTGATAAAGTTAATATATTTT
AGGATGTTATGTAAATATTTTTGCATGTATCTGTAGCTCCATCTTAATCAAATTTATGGTTAAAAGAGATTTGAGGCCAGGCGTGGAGGC
TCACACCTATAATCCCAACACTTTGGGAGGCCGAGGTGGGAGGATCACTTGAGCACAGGAGTTTGAGACCAGCCTGTGCAACATCATGAA
ACATCATCTCTACATAAAAAAATACATATATACAAAAATTAGCTGGGCATCATGGCACACACCTGTAGTCCCAGCTACTTAGGAGGCTGA
GATGGGAGGATTGATCGATCGCTTGAGCCTGGGAGGTGGAGGCTACTGTGAGCCATGATCATGCCACTGCACTCCAGCCTGGGCAACAGA
GTGAGACCCTGTCTCCAAAGAGAAAGAGAAACTTGAGAAGGCTTGTGCCCAAAGCTTGAAGAAAGATTGTAATAGCATTTAGTTGTGTTT
TATCATGTTATCTTCATAACATGCATTTTGCATATGGCTCAGAGCAGAGCCGGATCTCCCAAGGAAGCACAAATAGTTTTTGTCGCTAAC
TTAGTTATGAGTGAAGCCTCTGTTCACTTATAACTTGCCAGTTTCATTGGTGGAATAAGTCCCCTTACTCATGATTCATCAATATTCCTA
TATTAAAATTCCAGTTTGATGTTTGTCTCTAGTTGTCTGTGTATAATATTTCCAAAGCTCCTTTGTAAACCCCGTCTCCTTTCATTCAGA
GAGTCAGAGACGGTATCTCCTCCTCCTGCCTCTTCTATTGTTCTGATTAGTCTACTTAAATTCACTTGATGCTCTTTTTATTTTACAAGA
GACTTGAGAAATGTCGGTTGTTCCTAATGGCAAACTACTTTAGCTGGGAAAATTCATTTCAACTTATTTTAAGCTTGTAAAATACACTGT

>53358_53358_1_MGAT5-OLA1_MGAT5_chr2_135028121_ENST00000281923_OLA1_chr2_175006728_ENST00000284719_length(amino acids)=407AA_BP=135
MALFTPWKLSSQKLGFFLVTFGFIWGMMLLHFTIQQRTQPESSSMLREQILDLSKRYIKALAEENRNVVDGPYAGVMTAYDLKKTLAVLL
DNILQRIGKLESKVDNLVVNGTGTNSTNSTTAVPSLVALEKINVAGAFEDDDITHVEGSVDPIRDIEIIHEELQLKDEEMIGPIIDKLEK
VAVRGGDKKLKPEYDIMCKVKSWVIDQKKPVRFYHDWNDKEIEVLNKHLFLTSKPMVYLVNLSEKDYIRKKNKWLIKIKEWVDKYDPGAL
VIPFSGALELKLQELSAEERQKYLEANMTQSALPKIIKAGFAALQLEYFFTAGPDEVRAWTIRKGTKAPQAAGKIHTDFEKGFIMAEVMK

--------------------------------------------------------------
>53358_53358_2_MGAT5-OLA1_MGAT5_chr2_135028121_ENST00000409645_OLA1_chr2_175006728_ENST00000284719_length(transcript)=4455nt_BP=658nt
AGCCCAGGTAGCCGCGCCGCAGGCTCGGGGCGTCGCGACCTCGCGCCTCGGGCCGCGTGGGCACGGCGGCCGGCGGGTGCTCCCGGCTGC
TGCTGCTGCCCAACAAGGAGCAGAATGGAAGTGAGGAAAGGCAACCAGCTGACACAGGAGCCAGAGTGAGACCAGCAGACTCTCACACTC
AACCTACACCATGAATTTGTGTCTATCTTCTACGCGTTAAGAGCCAAGGACAGGTGAAGTTGCCAGAGAGCAATGGCTCTCTTCACTCCG
TGGAAGTTGTCCTCTCAGAAGCTGGGCTTTTTCCTGGTGACTTTTGGCTTCATTTGGGGTATGATGCTTCTGCACTTTACCATCCAGCAG
CGAACTCAGCCTGAAAGCAGCTCCATGCTGCGCGAGCAGATCCTGGACCTCAGCAAAAGGTACATCAAGGCACTGGCAGAAGAAAACAGG
AATGTGGTGGATGGGCCATACGCTGGAGTCATGACAGCTTATGATCTGAAGAAAACCCTTGCTGTGTTATTAGATAACATTTTGCAGCGC
ATTGGCAAGTTGGAGTCGAAGGTGGACAATCTTGTTGTCAATGGCACCGGAACAAACTCAACCAACTCCACTACAGCTGTTCCCAGCTTG
GTTGCACTTGAGAAAATTAATGTGGCAGGTGCTTTTGAAGATGATGATATCACGCACGTTGAAGGAAGTGTAGATCCTATTCGAGATATA
GAAATAATACATGAAGAGCTTCAGCTTAAAGATGAGGAAATGATTGGGCCCATTATAGATAAACTAGAAAAGGTGGCTGTGAGAGGAGGA
GATAAAAAACTAAAACCTGAATATGATATAATGTGCAAAGTAAAATCCTGGGTTATAGATCAAAAGAAACCTGTTCGCTTCTATCATGAT
TGGAATGACAAAGAGATTGAAGTGTTGAATAAACACTTATTTTTGACTTCAAAACCAATGGTCTACTTGGTTAATCTTTCTGAAAAAGAC
TACATTAGAAAGAAAAACAAATGGTTGATAAAAATTAAAGAGTGGGTGGACAAGTATGACCCAGGTGCTTTGGTCATTCCTTTTAGTGGG
GCCTTGGAACTCAAGTTGCAAGAATTGAGTGCTGAGGAGAGACAGAAGTATCTGGAAGCGAACATGACACAAAGTGCTTTGCCAAAGATC
ATTAAGGCTGGGTTTGCAGCACTCCAACTAGAATACTTTTTCACTGCAGGCCCAGATGAAGTGCGTGCATGGACCATCAGGAAAGGGACT
AAGGCTCCTCAGGCTGCAGGAAAGATTCACACAGATTTTGAAAAGGGATTCATTATGGCTGAAGTAATGAAATACGAAGATTTTAAAGAG
GAAGGTTCTGAAAATGCAGTCAAGGCTGCTGGAAAGTACAGACAACAAGGCAGAAATTATATTGTTGAAGATGGAGATATTATCTTCTTC
AAATTTAACACACCTCAACAACCGAAGAAGAAATAAAATTTAGTTATTGCTCAGATAAACATACAACTTCCAAAAGGCATCTGATTTTTA
AAAAATTAAAATTTCTGAAAACCAATGCGACAAATAAAGTTGGGGAGATGGGAATCTTTGACAAACAAATTATTTTTATTTGTTTTAAAA
TTAAAATACTGTGTACCCCCCCCCCCCCATGAAATGCAGGTTCACTAAATGTGAACAGCTTTGCTTTTCACGTGATTAAGACCCTACTCC
AAATTGTAGAAGCTTTTCAGGAACCATATTACTCTCATGATACTTCATTAATCTCCATCATGTATGCCAAGCCTGACACATTTGACAGTG
AGGACAATGTGGCTTGCTCCTTTTTGAATCTACAGATAATGCATGTTTTACAGTACTCCAGATGTCTACACTCAATAAAACATTTGACAA
AACCAGCCTTGGTGTGTTTGGGGATGTCTGTATTGACTGACTGTGGTGTGCTGAATGCGATACGGCACCTGGTGGTTGCTGATTACAGAA
TTTTAAGGCGTGTGTATGACACAGTAACTGGCAGTGTGGGGCAGCTGCAATTGTATCTTAAAAGTGAGTCTTTCATGGGAATCAGAAGAA
TAGTATACCAGGGATTTGTCTCAAAAAAGTTAATTAATTTATAGATCAACATTTATTGAAAGATGATAGCAATGATATTATGAGGGATAT
GAGATAGGTGACTGACCACAAAGAAGAAAATTCTGTCTCAAAAATTAAAGAATTTTGTTTGTTATTGTTGTTCTGACCATATTGAAAAGA
GGTTCACTTTTAATCTTTCCTTTGAAATTATTAAATTGTAAAAACTGACCCATTGATGTCTGGTGGGTTATGTTTTGCTTCAATTCAGCA
ATGTGTATAAAAGTTCCTACACTGATTTTGAAATACTAAGATCAGACTTTGAAAATTTTAAAAATTCTTTCATTCTTACTTTTCAGATAT
TTGAGAGCAGTCGAAGTGGTAGTATGGGTAAGTTAAGCACTTCTTAACATTGTAGCAGAAAATTCCAAAAGAAAGACTAGAACAAATTGG
TAATTTGGAGACCCTTTGCCACTTAGCCTTCTCTTGTGATGATGGCCTGAAAGCTCTCTCGGCCCTGAGCCTCCCTTTCTCTCCCATGTT
TCCATTCCTGTGAGACCTCCCTTCCTTGTCCTTGTCCTCTGCCCTTTTGTGCTCTTCTGTGATCACAGGACCATTTCCATGGAATGCAGA
TTCATACCCAGCCAGCCTTTGCCTCTACTGTATCGCTTTGGGACTTTAAAGATGCAGAAGTATTAGAACACACACAAACTTAAAATGGAA
AGTTACCAAATGTAGCACTAGAGGCAAGAAAAGGGGTGATTTTTTAAAGATTTGGCTATACTTAAGATATTTAAAGAGGATGAGGTTGAG
TCGTGAGTATAATTTAGAAGCTCTCCAGTGAGTATTTTTTTAGTATCAAATAGTGATCTTCTTTTGCTAACATAAAAATGAGTAAACTAC
AGCAGAGAAATAAGAATAAAACTAATGAAGGGTTTTTTAAAAGAACTAAATAAAACAAATAAAACTAGGCTACAGGTATAGCTGACCAAG
TTTGCTGTGAAAAATCCTTGTTATATCTATTTCTGTATTGGAGTAATGTGTAGATTAGTGGATTGTTAGGGATTTCAGCAGTATAAGAAA
GAATCAAATATCTTGCTTTTGGGTCTTCTCCAAAGTAAATTGCATGGACTTCTTAAAGAAGTTTGAAATCAGTAAAAAGACATTAGGATC
ATGCAATTTTACTTTGTCTAGCTTCTAATGTGGTAAATTGCACATTGTGCAACAGAACCATTAATAAAAGAAAGGAGTTAGTTTTGAGGT
AACTGCATTCATTAGGGGCTGAAAATAAATGTTAAAAATGTTTAATTTGGTTAGAAGTTCTACAACATTGTATGTACATATACAAAATTT
CATTTTCTCTGAAAGTCGAGAATTCCAAGAACTGTTACATATAATCATATATATGCCTATATCTAAACGTTTTCCCTCCTTTAATATTGA
TAAAGTTAATATATTTTAGGATGTTATGTAAATATTTTTGCATGTATCTGTAGCTCCATCTTAATCAAATTTATGGTTAAAAGAGATTTG
AGGCCAGGCGTGGAGGCTCACACCTATAATCCCAACACTTTGGGAGGCCGAGGTGGGAGGATCACTTGAGCACAGGAGTTTGAGACCAGC
CTGTGCAACATCATGAAACATCATCTCTACATAAAAAAATACATATATACAAAAATTAGCTGGGCATCATGGCACACACCTGTAGTCCCA
GCTACTTAGGAGGCTGAGATGGGAGGATTGATCGATCGCTTGAGCCTGGGAGGTGGAGGCTACTGTGAGCCATGATCATGCCACTGCACT
CCAGCCTGGGCAACAGAGTGAGACCCTGTCTCCAAAGAGAAAGAGAAACTTGAGAAGGCTTGTGCCCAAAGCTTGAAGAAAGATTGTAAT
AGCATTTAGTTGTGTTTTATCATGTTATCTTCATAACATGCATTTTGCATATGGCTCAGAGCAGAGCCGGATCTCCCAAGGAAGCACAAA
TAGTTTTTGTCGCTAACTTAGTTATGAGTGAAGCCTCTGTTCACTTATAACTTGCCAGTTTCATTGGTGGAATAAGTCCCCTTACTCATG
ATTCATCAATATTCCTATATTAAAATTCCAGTTTGATGTTTGTCTCTAGTTGTCTGTGTATAATATTTCCAAAGCTCCTTTGTAAACCCC
GTCTCCTTTCATTCAGAGAGTCAGAGACGGTATCTCCTCCTCCTGCCTCTTCTATTGTTCTGATTAGTCTACTTAAATTCACTTGATGCT
CTTTTTATTTTACAAGAGACTTGAGAAATGTCGGTTGTTCCTAATGGCAAACTACTTTAGCTGGGAAAATTCATTTCAACTTATTTTAAG

>53358_53358_2_MGAT5-OLA1_MGAT5_chr2_135028121_ENST00000409645_OLA1_chr2_175006728_ENST00000284719_length(amino acids)=407AA_BP=135
MALFTPWKLSSQKLGFFLVTFGFIWGMMLLHFTIQQRTQPESSSMLREQILDLSKRYIKALAEENRNVVDGPYAGVMTAYDLKKTLAVLL
DNILQRIGKLESKVDNLVVNGTGTNSTNSTTAVPSLVALEKINVAGAFEDDDITHVEGSVDPIRDIEIIHEELQLKDEEMIGPIIDKLEK
VAVRGGDKKLKPEYDIMCKVKSWVIDQKKPVRFYHDWNDKEIEVLNKHLFLTSKPMVYLVNLSEKDYIRKKNKWLIKIKEWVDKYDPGAL
VIPFSGALELKLQELSAEERQKYLEANMTQSALPKIIKAGFAALQLEYFFTAGPDEVRAWTIRKGTKAPQAAGKIHTDFEKGFIMAEVMK

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Top

Fusion Gene PPI Analysis for MGAT5-OLA1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for MGAT5-OLA1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for MGAT5-OLA1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source