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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MGP-ESR1 (FusionGDB2 ID:53416)

Fusion Gene Summary for MGP-ESR1

Fusion gene summary

Fusion gene information	Fusion gene name: MGP-ESR1
	Fusion gene ID: 53416
		Hgene	Tgene
	Gene symbol	MGP	ESR1
	Gene ID	4256	2099
	Gene name	matrix Gla protein	estrogen receptor 1
	Synonyms	GIG36\|MGLAP\|NTI	ER\|ESR\|ESRA\|ESTRR\|Era\|NR3A1
	Cytomap	12p12.3	6q25.1-q25.2
	Type of gene	protein-coding	protein-coding
	Description	matrix Gla proteincell growth-inhibiting gene 36 protein	estrogen receptorE2 receptor alphaER-alphaestradiol receptorestrogen nuclear receptor alphaestrogen receptor alpha E1-E2-1-2estrogen receptor alpha E1-N2-E2-1-2nuclear receptor subfamily 3 group A member 1oestrogen receptor alpha
	Modification date	20200313	20200329
	UniProtAcc	P08493	P03372
	Ensembl transtripts involved in fusion gene	ENST00000228938, ENST00000539261,	ENST00000206249, ENST00000406599, ENST00000427531, ENST00000443427, ENST00000456483, ENST00000482101, ENST00000338799, ENST00000440973,
Fusion gene scores	* DoF score	7 X 8 X 2=112	10 X 10 X 6=600
	# samples	8	12
	** MAII score	log2(8/112*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/600*10)=-2.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MGP [Title/Abstract] AND ESR1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MGP(15037147)-ESR1(152265308), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ESR1	GO:0006366	transcription by RNA polymerase II	15831516
Tgene	ESR1	GO:0010629	negative regulation of gene expression	21695196
Tgene	ESR1	GO:0030520	intracellular estrogen receptor signaling pathway	9841876
Tgene	ESR1	GO:0032355	response to estradiol	15304487
Tgene	ESR1	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	7651415\|16043358
Tgene	ESR1	GO:0043433	negative regulation of DNA-binding transcription factor activity	10816575
Tgene	ESR1	GO:0043627	response to estrogen	11581164
Tgene	ESR1	GO:0045893	positive regulation of transcription, DNA-templated	9841876\|20074560
Tgene	ESR1	GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	9841876
Tgene	ESR1	GO:0045944	positive regulation of transcription by RNA polymerase II	11544182\|12047722\|15345745\|15831516\|18563714
Tgene	ESR1	GO:0051091	positive regulation of DNA-binding transcription factor activity	9328340\|10681512
Tgene	ESR1	GO:0071392	cellular response to estradiol stimulus	15831516

Fusion gene breakpoints across MGP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ESR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AR-A0U3-01A	MGP	chr12	15037147	-	ESR1	chr6	152265308	+

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Fusion Gene ORF analysis for MGP-ESR1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000228938	ENST00000206249	MGP	chr12	15037147	-	ESR1	chr6	152265308	+
5CDS-intron	ENST00000228938	ENST00000406599	MGP	chr12	15037147	-	ESR1	chr6	152265308	+
5CDS-intron	ENST00000228938	ENST00000427531	MGP	chr12	15037147	-	ESR1	chr6	152265308	+
5CDS-intron	ENST00000228938	ENST00000443427	MGP	chr12	15037147	-	ESR1	chr6	152265308	+
5CDS-intron	ENST00000228938	ENST00000456483	MGP	chr12	15037147	-	ESR1	chr6	152265308	+
5CDS-intron	ENST00000228938	ENST00000482101	MGP	chr12	15037147	-	ESR1	chr6	152265308	+
5CDS-intron	ENST00000539261	ENST00000206249	MGP	chr12	15037147	-	ESR1	chr6	152265308	+
5CDS-intron	ENST00000539261	ENST00000406599	MGP	chr12	15037147	-	ESR1	chr6	152265308	+
5CDS-intron	ENST00000539261	ENST00000427531	MGP	chr12	15037147	-	ESR1	chr6	152265308	+
5CDS-intron	ENST00000539261	ENST00000443427	MGP	chr12	15037147	-	ESR1	chr6	152265308	+
5CDS-intron	ENST00000539261	ENST00000456483	MGP	chr12	15037147	-	ESR1	chr6	152265308	+
5CDS-intron	ENST00000539261	ENST00000482101	MGP	chr12	15037147	-	ESR1	chr6	152265308	+
In-frame	ENST00000228938	ENST00000338799	MGP	chr12	15037147	-	ESR1	chr6	152265308	+
In-frame	ENST00000228938	ENST00000440973	MGP	chr12	15037147	-	ESR1	chr6	152265308	+
In-frame	ENST00000539261	ENST00000338799	MGP	chr12	15037147	-	ESR1	chr6	152265308	+
In-frame	ENST00000539261	ENST00000440973	MGP	chr12	15037147	-	ESR1	chr6	152265308	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000539261	MGP	chr12	15037147	-	ENST00000440973	ESR1	chr6	152265308	+	5565	229	120	1256	378
ENST00000539261	MGP	chr12	15037147	-	ENST00000338799	ESR1	chr6	152265308	+	1344	229	120	1256	378
ENST00000228938	MGP	chr12	15037147	-	ENST00000440973	ESR1	chr6	152265308	+	5571	235	51	1262	403
ENST00000228938	MGP	chr12	15037147	-	ENST00000338799	ESR1	chr6	152265308	+	1350	235	51	1262	403

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000539261	ENST00000440973	MGP	chr12	15037147	-	ESR1	chr6	152265308	+	0.000268249	0.9997317
ENST00000539261	ENST00000338799	MGP	chr12	15037147	-	ESR1	chr6	152265308	+	0.001521871	0.9984781
ENST00000228938	ENST00000440973	MGP	chr12	15037147	-	ESR1	chr6	152265308	+	0.000232732	0.99976724
ENST00000228938	ENST00000338799	MGP	chr12	15037147	-	ESR1	chr6	152265308	+	0.001832375	0.99816763

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Fusion Genomic Features for MGP-ESR1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MGP-ESR1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:15037147/chr6:152265308)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MGP P08493	ESR1 P03372
FUNCTION: Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.	FUNCTION: Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation of NOS3 and endothelial nitric oxide production. Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3. Isoform 3 can bind to ERE and inhibit isoform 1. {ECO:0000269\|PubMed:10681512, ECO:0000269\|PubMed:10816575, ECO:0000269\|PubMed:11477071, ECO:0000269\|PubMed:11682626, ECO:0000269\|PubMed:14764652, ECO:0000269\|PubMed:15078875, ECO:0000269\|PubMed:15891768, ECO:0000269\|PubMed:16043358, ECO:0000269\|PubMed:16617102, ECO:0000269\|PubMed:16684779, ECO:0000269\|PubMed:17922032, ECO:0000269\|PubMed:17932106, ECO:0000269\|PubMed:18247370, ECO:0000269\|PubMed:19350539, ECO:0000269\|PubMed:20074560, ECO:0000269\|PubMed:20705611, ECO:0000269\|PubMed:21330404, ECO:0000269\|PubMed:22083956, ECO:0000269\|PubMed:7651415, ECO:0000269\|PubMed:9328340}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ESR1

chr12:15037147

chr6:152265308

ENST00000456483

185_250

484.0

DNA binding

Nuclear receptor

Tgene

ESR1

chr12:15037147

chr6:152265308

ENST00000206249

311_547

253

596.0

Domain

NR LBD

Tgene

ESR1

chr12:15037147

chr6:152265308

ENST00000338799

311_547

253

596.0

Domain

NR LBD

Tgene

ESR1

chr12:15037147

chr6:152265308

ENST00000440973

311_547

253

596.0

Domain

NR LBD

Tgene

ESR1

chr12:15037147

chr6:152265308

ENST00000443427

311_547

253

596.0

Domain

NR LBD

Tgene

ESR1

chr12:15037147

chr6:152265308

ENST00000456483

311_547

484.0

Domain

NR LBD

Tgene

ESR1

chr12:15037147

chr6:152265308

ENST00000206249

251_310

253

596.0

Region

Note=Hinge

Tgene

ESR1

chr12:15037147

chr6:152265308

ENST00000206249

264_595

253

596.0

Region

Note=Self-association

Tgene

ESR1

chr12:15037147

chr6:152265308

ENST00000206249

311_595

253

596.0

Region

Note=Transactivation AF-2

Tgene

ESR1

chr12:15037147

chr6:152265308

ENST00000338799

251_310

253

596.0

Region

Note=Hinge

Tgene

ESR1

chr12:15037147

chr6:152265308

ENST00000338799

264_595

253

596.0

Region

Note=Self-association

Tgene

ESR1

chr12:15037147

chr6:152265308

ENST00000338799

311_595

253

596.0

Region

Note=Transactivation AF-2

Tgene

ESR1

chr12:15037147

chr6:152265308

ENST00000440973

251_310

253

596.0

Region

Note=Hinge

Tgene

ESR1

chr12:15037147

chr6:152265308

ENST00000440973

264_595

253

596.0

Region

Note=Self-association

Tgene

ESR1

chr12:15037147

chr6:152265308

ENST00000440973

311_595

253

596.0

Region

Note=Transactivation AF-2

Tgene

ESR1

chr12:15037147

chr6:152265308

ENST00000443427

251_310

253

596.0

Region

Note=Hinge

Tgene

ESR1

chr12:15037147

chr6:152265308

ENST00000443427

264_595

253

596.0

Region

Note=Self-association

Tgene

ESR1

chr12:15037147

chr6:152265308

ENST00000443427

311_595

253

596.0

Region

Note=Transactivation AF-2

Tgene

ESR1

chr12:15037147

chr6:152265308

ENST00000456483

251_310

484.0

Region

Note=Hinge

Tgene

ESR1

chr12:15037147

chr6:152265308

ENST00000456483

264_595

484.0

Region

Note=Self-association

Tgene

ESR1

chr12:15037147

chr6:152265308

ENST00000456483

311_595

484.0

Region

Note=Transactivation AF-2

Tgene

ESR1

chr12:15037147

chr6:152265308

ENST00000456483

185_205

484.0

Zinc finger

NR C4-type

Tgene

ESR1

chr12:15037147

chr6:152265308

ENST00000456483

221_245

484.0

Zinc finger

NR C4-type

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MGP

chr12:15037147

chr6:152265308

ENST00000228938

51_97

129.0

Domain

Gla

Hgene

MGP

chr12:15037147

chr6:152265308

ENST00000539261

51_97

104.0

Domain

Gla

Tgene

ESR1

chr12:15037147

chr6:152265308

ENST00000206249

185_250

253

596.0

DNA binding

Nuclear receptor

Tgene

ESR1

chr12:15037147

chr6:152265308

ENST00000338799

185_250

253

596.0

DNA binding

Nuclear receptor

Tgene

ESR1

chr12:15037147

chr6:152265308

ENST00000440973

185_250

253

596.0

DNA binding

Nuclear receptor

Tgene

ESR1

chr12:15037147

chr6:152265308

ENST00000443427

185_250

253

596.0

DNA binding

Nuclear receptor

Tgene

ESR1

chr12:15037147

chr6:152265308

ENST00000206249

185_205

253

596.0

Zinc finger

NR C4-type

Tgene

ESR1

chr12:15037147

chr6:152265308

ENST00000206249

221_245

253

596.0

Zinc finger

NR C4-type

Tgene

ESR1

chr12:15037147

chr6:152265308

ENST00000338799

185_205

253

596.0

Zinc finger

NR C4-type

Tgene

ESR1

chr12:15037147

chr6:152265308

ENST00000338799

221_245

253

596.0

Zinc finger

NR C4-type

Tgene

ESR1

chr12:15037147

chr6:152265308

ENST00000440973

185_205

253

596.0

Zinc finger

NR C4-type

Tgene

ESR1

chr12:15037147

chr6:152265308

ENST00000440973

221_245

253

596.0

Zinc finger

NR C4-type

Tgene

ESR1

chr12:15037147

chr6:152265308

ENST00000443427

185_205

253

596.0

Zinc finger

NR C4-type

Tgene

ESR1

chr12:15037147

chr6:152265308

ENST00000443427

221_245

253

596.0

Zinc finger

NR C4-type

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Fusion Gene Sequence for MGP-ESR1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>53416_53416_1_MGP-ESR1_MGP_chr12_15037147_ENST00000228938_ESR1_chr6_152265308_ENST00000338799_length(transcript)=1350nt_BP=235nt
CCCGTAGGAGCCTCTCTCCCTACTGCTGCTACACAAGACCCTGAGACTGACCTGCAGGACGAAACCATGAAGAGCCTGATCCTTCTTGCC
ATCCTGGCCGCCTTAGCGGTAGTAACTTTGTGTTATGGAGAGTGGCAGAAAGAAGAAAACTTCGGCTTTGATATCGTTTCAGTTCTCTCT
CTGAACTGGCATCGTGCCCAGGAATCACATGAAAGCATGGAATCTTATGAACTTAGGATACGAAAAGACCGAAGAGGAGGGAGAATGTTG
AAACACAAGCGCCAGAGAGATGATGGGGAGGGCAGGGGTGAAGTGGGGTCTGCTGGAGACATGAGAGCTGCCAACCTTTGGCCAAGCCCG
CTCATGATCAAACGCTCTAAGAAGAACAGCCTGGCCTTGTCCCTGACGGCCGACCAGATGGTCAGTGCCTTGTTGGATGCTGAGCCCCCG
ATACTCTATTCCGAGTATGATCCTACCAGACCCTTCAGTGAAGCTTCGATGATGGGCTTACTGACCAACCTGGCAGACAGGGAGCTGGTT
CACATGATCAACTGGGCGAAGAGGGTGCCAGGCTTTGTGGATTTGACCCTCCATGATCAGGTCCACCTTCTAGAATGTGCCTGGCTAGAG
ATCCTGATGATTGGTCTCGTCTGGCGCTCCATGGAGCACCCAGGGAAGCTACTGTTTGCTCCTAACTTGCTCTTGGACAGGAACCAGGGA
AAATGTGTAGAGGGCATGGTGGAGATCTTCGACATGCTGCTGGCTACATCATCTCGGTTCCGCATGATGAATCTGCAGGGAGAGGAGTTT
GTGTGCCTCAAATCTATTATTTTGCTTAATTCTGGAGTGTACACATTTCTGTCCAGCACCCTGAAGTCTCTGGAAGAGAAGGACCATATC
CACCGAGTCCTGGACAAGATCACAGACACTTTGATCCACCTGATGGCCAAGGCAGGCCTGACCCTGCAGCAGCAGCACCAGCGGCTGGCC
CAGCTCCTCCTCATCCTCTCCCACATCAGGCACATGAGTAACAAAGGCATGGAGCATCTGTACAGCATGAAGTGCAAGAACGTGGTGCCC
CTCTATGACCTGCTGCTGGAGATGCTGGACGCCCACCGCCTACATGCGCCCACTAGCCGTGGAGGGGCATCCGTGGAGGAGACGGACCAA
AGCCACTTGGCCACTGCGGGCTCTACTTCATCGCATTCCTTGCAAAAGTATTACATCACGGGGGAGGCAGAGGGTTTCCCTGCCACGGTC
TGAGAGCTCCCTGGCTCCCACACGGTTCAGATAATCCCTGCTGCATTTTACCCTCATCATGCACCACTTTAGCCAAATTCTGTCTCCTGC

>53416_53416_1_MGP-ESR1_MGP_chr12_15037147_ENST00000228938_ESR1_chr6_152265308_ENST00000338799_length(amino acids)=403AA_BP=62
MQDETMKSLILLAILAALAVVTLCYGEWQKEENFGFDIVSVLSLNWHRAQESHESMESYELRIRKDRRGGRMLKHKRQRDDGEGRGEVGS
AGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTL
HDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFL
SSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAP

--------------------------------------------------------------
>53416_53416_2_MGP-ESR1_MGP_chr12_15037147_ENST00000228938_ESR1_chr6_152265308_ENST00000440973_length(transcript)=5571nt_BP=235nt
CCCGTAGGAGCCTCTCTCCCTACTGCTGCTACACAAGACCCTGAGACTGACCTGCAGGACGAAACCATGAAGAGCCTGATCCTTCTTGCC
ATCCTGGCCGCCTTAGCGGTAGTAACTTTGTGTTATGGAGAGTGGCAGAAAGAAGAAAACTTCGGCTTTGATATCGTTTCAGTTCTCTCT
CTGAACTGGCATCGTGCCCAGGAATCACATGAAAGCATGGAATCTTATGAACTTAGGATACGAAAAGACCGAAGAGGAGGGAGAATGTTG
AAACACAAGCGCCAGAGAGATGATGGGGAGGGCAGGGGTGAAGTGGGGTCTGCTGGAGACATGAGAGCTGCCAACCTTTGGCCAAGCCCG
CTCATGATCAAACGCTCTAAGAAGAACAGCCTGGCCTTGTCCCTGACGGCCGACCAGATGGTCAGTGCCTTGTTGGATGCTGAGCCCCCG
ATACTCTATTCCGAGTATGATCCTACCAGACCCTTCAGTGAAGCTTCGATGATGGGCTTACTGACCAACCTGGCAGACAGGGAGCTGGTT
CACATGATCAACTGGGCGAAGAGGGTGCCAGGCTTTGTGGATTTGACCCTCCATGATCAGGTCCACCTTCTAGAATGTGCCTGGCTAGAG
ATCCTGATGATTGGTCTCGTCTGGCGCTCCATGGAGCACCCAGGGAAGCTACTGTTTGCTCCTAACTTGCTCTTGGACAGGAACCAGGGA
AAATGTGTAGAGGGCATGGTGGAGATCTTCGACATGCTGCTGGCTACATCATCTCGGTTCCGCATGATGAATCTGCAGGGAGAGGAGTTT
GTGTGCCTCAAATCTATTATTTTGCTTAATTCTGGAGTGTACACATTTCTGTCCAGCACCCTGAAGTCTCTGGAAGAGAAGGACCATATC
CACCGAGTCCTGGACAAGATCACAGACACTTTGATCCACCTGATGGCCAAGGCAGGCCTGACCCTGCAGCAGCAGCACCAGCGGCTGGCC
CAGCTCCTCCTCATCCTCTCCCACATCAGGCACATGAGTAACAAAGGCATGGAGCATCTGTACAGCATGAAGTGCAAGAACGTGGTGCCC
CTCTATGACCTGCTGCTGGAGATGCTGGACGCCCACCGCCTACATGCGCCCACTAGCCGTGGAGGGGCATCCGTGGAGGAGACGGACCAA
AGCCACTTGGCCACTGCGGGCTCTACTTCATCGCATTCCTTGCAAAAGTATTACATCACGGGGGAGGCAGAGGGTTTCCCTGCCACGGTC
TGAGAGCTCCCTGGCTCCCACACGGTTCAGATAATCCCTGCTGCATTTTACCCTCATCATGCACCACTTTAGCCAAATTCTGTCTCCTGC
ATACACTCCGGCATGCATCCAACACCAATGGCTTTCTAGATGAGTGGCCATTCATTTGCTTGCTCAGTTCTTAGTGGCACATCTTCTGTC
TTCTGTTGGGAACAGCCAAAGGGATTCCAAGGCTAAATCTTTGTAACAGCTCTCTTTCCCCCTTGCTATGTTACTAAGCGTGAGGATTCC
CGTAGCTCTTCACAGCTGAACTCAGTCTATGGGTTGGGGCTCAGATAACTCTGTGCATTTAAGCTACTTGTAGAGACCCAGGCCTGGAGA
GTAGACATTTTGCCTCTGATAAGCACTTTTTAAATGGCTCTAAGAATAAGCCACAGCAAAGAATTTAAAGTGGCTCCTTTAATTGGTGAC
TTGGAGAAAGCTAGGTCAAGGGTTTATTATAGCACCCTCTTGTATTCCTATGGCAATGCATCCTTTTATGAAAGTGGTACACCTTAAAGC
TTTTATATGACTGTAGCAGAGTATCTGGTGATTGTCAATTCATTCCCCCTATAGGAATACAAGGGGCACACAGGGAAGGCAGATCCCCTA
GTTGGCAAGACTATTTTAACTTGATACACTGCAGATTCAGATGTGCTGAAAGCTCTGCCTCTGGCTTTCCGGTCATGGGTTCCAGTTAAT
TCATGCCTCCCATGGACCTATGGAGAGCAGCAAGTTGATCTTAGTTAAGTCTCCCTATATGAGGGATAAGTTCCTGATTTTTGTTTTTAT
TTTTGTGTTACAAAAGAAAGCCCTCCCTCCCTGAACTTGCAGTAAGGTCAGCTTCAGGACCTGTTCCAGTGGGCACTGTACTTGGATCTT
CCCGGCGTGTGTGTGCCTTACACAGGGGTGAACTGTTCACTGTGGTGATGCATGATGAGGGTAAATGGTAGTTGAAAGGAGCAGGGGCCC
TGGTGTTGCATTTAGCCCTGGGGCATGGAGCTGAACAGTACTTGTGCAGGATTGTTGTGGCTACTAGAGAACAAGAGGGAAAGTAGGGCA
GAAACTGGATACAGTTCTGAGGCACAGCCAGACTTGCTCAGGGTGGCCCTGCCACAGGCTGCAGCTACCTAGGAACATTCCTTGCAGACC
CCGCATTGCCCTTTGGGGGTGCCCTGGGATCCCTGGGGTAGTCCAGCTCTTCTTCATTTCCCAGCGTGGCCCTGGTTGGAAGAAGCAGCT
GTCACAGCTGCTGTAGACAGCTGTGTTCCTACAATTGGCCCAGCACCCTGGGGCACGGGAGAAGGGTGGGGACCGTTGCTGTCACTACTC
AGGCTGACTGGGGCCTGGTCAGATTACGTATGCCCTTGGTGGTTTAGAGATAATCCAAAATCAGGGTTTGGTTTGGGGAAGAAAATCCTC
CCCCTTCCTCCCCCGCCCCGTTCCCTACCGCCTCCACTCCTGCCAGCTCATTTCCTTCAATTTCCTTTGACCTATAGGCTAAAAAAGAAA
GGCTCATTCCAGCCACAGGGCAGCCTTCCCTGGGCCTTTGCTTCTCTAGCACAATTATGGGTTACTTCCTTTTTCTTAACAAAAAAGAAT
GTTTGATTTCCTCTGGGTGACCTTATTGTCTGTAATTGAAACCCTATTGAGAGGTGATGTCTGTGTTAGCCAATGACCCAGGTGAGCTGC
TCGGGCTTCTCTTGGTATGTCTTGTTTGGAAAAGTGGATTTCATTCATTTCTGATTGTCCAGTTAAGTGATCACCAAAGGACTGAGAATC
TGGGAGGGCAAAAAAAAAAAAAAAGTTTTTATGTGCACTTAAATTTGGGGACAATTTTATGTATCTGTGTTAAGGATATGTTTAAGAACA
TAATTCTTTTGTTGCTGTTTGTTTAAGAAGCACCTTAGTTTGTTTAAGAAGCACCTTATATAGTATAATATATATTTTTTTGAAATTACA
TTGCTTGTTTATCAGACAATTGAATGTAGTAATTCTGTTCTGGATTTAATTTGACTGGGTTAACATGCAAAAACCAAGGAAAAATATTTA
GTTTTTTTTTTTTTTTTTGTATACTTTTCAAGCTACCTTGTCATGTATACAGTCATTTATGCCTAAAGCCTGGTGATTATTCATTTAAAT
GAAGATCACATTTCATATCAACTTTTGTATCCACAGTAGACAAAATAGCACTAATCCAGATGCCTATTGTTGGATACTGAATGACAGACA
ATCTTATGTAGCAAAGATTATGCCTGAAAAGGAAAATTATTCAGGGCAGCTAATTTTGCTTTTACCAAAATATCAGTAGTAATATTTTTG
GACAGTAGCTAATGGGTCAGTGGGTTCTTTTTAATGTTTATACTTAGATTTTCTTTTAAAAAAATTAAAATAAAACAAAAAAAAATTTCT
AGGACTAGACGATGTAATACCAGCTAAAGCCAAACAATTATACAGTGGAAGGTTTTACATTATTCATCCAATGTGTTTCTATTCATGTTA
AGATACTACTACATTTGAAGTGGGCAGAGAACATCAGATGATTGAAATGTTCGCCCAGGGGTCTCCAGCAACTTTGGAAATCTCTTTGTA
TTTTTACTTGAAGTGCCACTAATGGACAGCAGATATTTTCTGGCTGATGTTGGTATTGGGTGTAGGAACATGATTTAAAAAAAAACTCTT
GCCTCTGCTTTCCCCCACTCTGAGGCAAGTTAAAATGTAAAAGATGTGATTTATCTGGGGGGCTCAGGTATGGTGGGGAAGTGGATTCAG
GAATCTGGGGAATGGCAAATATATTAAGAAGAGTATTGAAAGTATTTGGAGGAAAATGGTTAATTCTGGGTGTGCACCAGGGTTCAGTAG
AGTCCACTTCTGCCCTGGAGACCACAAATCAACTAGCTCCATTTACAGCCATTTCTAAAATGGCAGCTTCAGTTCTAGAGAAGAAAGAAC
AACATCAGCAGTAAAGTCCATGGAATAGCTAGTGGTCTGTGTTTCTTTTCGCCATTGCCTAGCTTGCCGTAATGATTCTATAATGCCATC
ATGCAGCAATTATGAGAGGCTAGGTCATCCAAAGAGAAGACCCTATCAATGTAGGTTGCAAAATCTAACCCCTAAGGAAGTGCAGTCTTT
GATTTGATTTCCCTAGTAACCTTGCAGATATGTTTAACCAAGCCATAGCCCATGCCTTTTGAGGGCTGAACAAATAAGGGACTTACTGAT
AATTTACTTTTGATCACATTAAGGTGTTCTCACCTTGAAATCTTATACACTGAAATGGCCATTGATTTAGGCCACTGGCTTAGAGTACTC
CTTCCCCTGCATGACACTGATTACAAATACTTTCCTATTCATACTTTCCAATTATGAGATGGACTGTGGGTACTGGGAGTGATCACTAAC
ACCATAGTAATGTCTAATATTCACAGGCAGATCTGCTTGGGGAAGCTAGTTATGTGAAAGGCAAATAGAGTCATACAGTAGCTCAAAAGG
CAACCATAATTCTCTTTGGTGCAGGTCTTGGGAGCGTGATCTAGATTACACTGCACCATTCCCAAGTTAATCCCCTGAAAACTTACTCTC
AACTGGAGCAAATGAACTTTGGTCCCAAATATCCATCTTTTCAGTAGCGTTAATTATGCTCTGTTTCCAACTGCATTTCCTTTCCAATTG
AATTAAAGTGTGGCCTCGTTTTTAGTCATTTAAAATTGTTTTCTAAGTAATTGCTGCCTCTATTATGGCACTTCAATTTTGCACTGTCTT
TTGAGATTCAAGAAAAATTTCTATTCTTTTTTTTGCATCCAATTGTGCCTGAACTTTTAAAATATGTAAATGCTGCCATGTTCCAAACCC
ATCGTCAGTGTGTGTGTTTAGAGCTGTGCACCCTAGAAACAACATATTGTCCCATGAGCAGGTGCCTGAGACACAGACCCCTTTGCATTC
ACAGAGAGGTCATTGGTTATAGAGACTTGAATTAATAAGTGACATTATGCCAGTTTCTGTTCTCTCACAGGTGATAAACAATGCTTTTTG
TGCACTACATACTCTTCAGTGTAGAGCTCTTGTTTTATGGGAAAAGGCTCAAATGCCAAATTGTGTTTGATGGATTAATATGCCCTTTTG
CCGATGCATACTATTACTGATGTGACTCGGTTTTGTCGCAGCTTTGCTTTGTTTAATGAAACACACTTGTAAACCTCTTTTGCACTTTGA

>53416_53416_2_MGP-ESR1_MGP_chr12_15037147_ENST00000228938_ESR1_chr6_152265308_ENST00000440973_length(amino acids)=403AA_BP=62
MQDETMKSLILLAILAALAVVTLCYGEWQKEENFGFDIVSVLSLNWHRAQESHESMESYELRIRKDRRGGRMLKHKRQRDDGEGRGEVGS
AGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTL
HDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFL
SSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAP

--------------------------------------------------------------
>53416_53416_3_MGP-ESR1_MGP_chr12_15037147_ENST00000539261_ESR1_chr6_152265308_ENST00000338799_length(transcript)=1344nt_BP=229nt
TCTCCCACTGGTTCCTCCCCTCTCAACTGCTCTGGTTCTTATAAAAACCTCACAGCCTTCCACTAACATCCCGTAGGAGCCTCTCTCCCT
ACTGCTGCTACACAAGACCCTGAGACTGACCTGCAGGACGAAACCATGAAGAGCCTGATCCTTCTTGCCATCCTGGCCGCCTTAGCGGTA
GTAACTTTGTGTTATGAATCACATGAAAGCATGGAATCTTATGAACTTAGGATACGAAAAGACCGAAGAGGAGGGAGAATGTTGAAACAC
AAGCGCCAGAGAGATGATGGGGAGGGCAGGGGTGAAGTGGGGTCTGCTGGAGACATGAGAGCTGCCAACCTTTGGCCAAGCCCGCTCATG
ATCAAACGCTCTAAGAAGAACAGCCTGGCCTTGTCCCTGACGGCCGACCAGATGGTCAGTGCCTTGTTGGATGCTGAGCCCCCGATACTC
TATTCCGAGTATGATCCTACCAGACCCTTCAGTGAAGCTTCGATGATGGGCTTACTGACCAACCTGGCAGACAGGGAGCTGGTTCACATG
ATCAACTGGGCGAAGAGGGTGCCAGGCTTTGTGGATTTGACCCTCCATGATCAGGTCCACCTTCTAGAATGTGCCTGGCTAGAGATCCTG
ATGATTGGTCTCGTCTGGCGCTCCATGGAGCACCCAGGGAAGCTACTGTTTGCTCCTAACTTGCTCTTGGACAGGAACCAGGGAAAATGT
GTAGAGGGCATGGTGGAGATCTTCGACATGCTGCTGGCTACATCATCTCGGTTCCGCATGATGAATCTGCAGGGAGAGGAGTTTGTGTGC
CTCAAATCTATTATTTTGCTTAATTCTGGAGTGTACACATTTCTGTCCAGCACCCTGAAGTCTCTGGAAGAGAAGGACCATATCCACCGA
GTCCTGGACAAGATCACAGACACTTTGATCCACCTGATGGCCAAGGCAGGCCTGACCCTGCAGCAGCAGCACCAGCGGCTGGCCCAGCTC
CTCCTCATCCTCTCCCACATCAGGCACATGAGTAACAAAGGCATGGAGCATCTGTACAGCATGAAGTGCAAGAACGTGGTGCCCCTCTAT
GACCTGCTGCTGGAGATGCTGGACGCCCACCGCCTACATGCGCCCACTAGCCGTGGAGGGGCATCCGTGGAGGAGACGGACCAAAGCCAC
TTGGCCACTGCGGGCTCTACTTCATCGCATTCCTTGCAAAAGTATTACATCACGGGGGAGGCAGAGGGTTTCCCTGCCACGGTCTGAGAG

>53416_53416_3_MGP-ESR1_MGP_chr12_15037147_ENST00000539261_ESR1_chr6_152265308_ENST00000338799_length(amino acids)=378AA_BP=37
MQDETMKSLILLAILAALAVVTLCYESHESMESYELRIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLA
LSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSME
HPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLI
HLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSH

--------------------------------------------------------------
>53416_53416_4_MGP-ESR1_MGP_chr12_15037147_ENST00000539261_ESR1_chr6_152265308_ENST00000440973_length(transcript)=5565nt_BP=229nt
TCTCCCACTGGTTCCTCCCCTCTCAACTGCTCTGGTTCTTATAAAAACCTCACAGCCTTCCACTAACATCCCGTAGGAGCCTCTCTCCCT
ACTGCTGCTACACAAGACCCTGAGACTGACCTGCAGGACGAAACCATGAAGAGCCTGATCCTTCTTGCCATCCTGGCCGCCTTAGCGGTA
GTAACTTTGTGTTATGAATCACATGAAAGCATGGAATCTTATGAACTTAGGATACGAAAAGACCGAAGAGGAGGGAGAATGTTGAAACAC
AAGCGCCAGAGAGATGATGGGGAGGGCAGGGGTGAAGTGGGGTCTGCTGGAGACATGAGAGCTGCCAACCTTTGGCCAAGCCCGCTCATG
ATCAAACGCTCTAAGAAGAACAGCCTGGCCTTGTCCCTGACGGCCGACCAGATGGTCAGTGCCTTGTTGGATGCTGAGCCCCCGATACTC
TATTCCGAGTATGATCCTACCAGACCCTTCAGTGAAGCTTCGATGATGGGCTTACTGACCAACCTGGCAGACAGGGAGCTGGTTCACATG
ATCAACTGGGCGAAGAGGGTGCCAGGCTTTGTGGATTTGACCCTCCATGATCAGGTCCACCTTCTAGAATGTGCCTGGCTAGAGATCCTG
ATGATTGGTCTCGTCTGGCGCTCCATGGAGCACCCAGGGAAGCTACTGTTTGCTCCTAACTTGCTCTTGGACAGGAACCAGGGAAAATGT
GTAGAGGGCATGGTGGAGATCTTCGACATGCTGCTGGCTACATCATCTCGGTTCCGCATGATGAATCTGCAGGGAGAGGAGTTTGTGTGC
CTCAAATCTATTATTTTGCTTAATTCTGGAGTGTACACATTTCTGTCCAGCACCCTGAAGTCTCTGGAAGAGAAGGACCATATCCACCGA
GTCCTGGACAAGATCACAGACACTTTGATCCACCTGATGGCCAAGGCAGGCCTGACCCTGCAGCAGCAGCACCAGCGGCTGGCCCAGCTC
CTCCTCATCCTCTCCCACATCAGGCACATGAGTAACAAAGGCATGGAGCATCTGTACAGCATGAAGTGCAAGAACGTGGTGCCCCTCTAT
GACCTGCTGCTGGAGATGCTGGACGCCCACCGCCTACATGCGCCCACTAGCCGTGGAGGGGCATCCGTGGAGGAGACGGACCAAAGCCAC
TTGGCCACTGCGGGCTCTACTTCATCGCATTCCTTGCAAAAGTATTACATCACGGGGGAGGCAGAGGGTTTCCCTGCCACGGTCTGAGAG
CTCCCTGGCTCCCACACGGTTCAGATAATCCCTGCTGCATTTTACCCTCATCATGCACCACTTTAGCCAAATTCTGTCTCCTGCATACAC
TCCGGCATGCATCCAACACCAATGGCTTTCTAGATGAGTGGCCATTCATTTGCTTGCTCAGTTCTTAGTGGCACATCTTCTGTCTTCTGT
TGGGAACAGCCAAAGGGATTCCAAGGCTAAATCTTTGTAACAGCTCTCTTTCCCCCTTGCTATGTTACTAAGCGTGAGGATTCCCGTAGC
TCTTCACAGCTGAACTCAGTCTATGGGTTGGGGCTCAGATAACTCTGTGCATTTAAGCTACTTGTAGAGACCCAGGCCTGGAGAGTAGAC
ATTTTGCCTCTGATAAGCACTTTTTAAATGGCTCTAAGAATAAGCCACAGCAAAGAATTTAAAGTGGCTCCTTTAATTGGTGACTTGGAG
AAAGCTAGGTCAAGGGTTTATTATAGCACCCTCTTGTATTCCTATGGCAATGCATCCTTTTATGAAAGTGGTACACCTTAAAGCTTTTAT
ATGACTGTAGCAGAGTATCTGGTGATTGTCAATTCATTCCCCCTATAGGAATACAAGGGGCACACAGGGAAGGCAGATCCCCTAGTTGGC
AAGACTATTTTAACTTGATACACTGCAGATTCAGATGTGCTGAAAGCTCTGCCTCTGGCTTTCCGGTCATGGGTTCCAGTTAATTCATGC
CTCCCATGGACCTATGGAGAGCAGCAAGTTGATCTTAGTTAAGTCTCCCTATATGAGGGATAAGTTCCTGATTTTTGTTTTTATTTTTGT
GTTACAAAAGAAAGCCCTCCCTCCCTGAACTTGCAGTAAGGTCAGCTTCAGGACCTGTTCCAGTGGGCACTGTACTTGGATCTTCCCGGC
GTGTGTGTGCCTTACACAGGGGTGAACTGTTCACTGTGGTGATGCATGATGAGGGTAAATGGTAGTTGAAAGGAGCAGGGGCCCTGGTGT
TGCATTTAGCCCTGGGGCATGGAGCTGAACAGTACTTGTGCAGGATTGTTGTGGCTACTAGAGAACAAGAGGGAAAGTAGGGCAGAAACT
GGATACAGTTCTGAGGCACAGCCAGACTTGCTCAGGGTGGCCCTGCCACAGGCTGCAGCTACCTAGGAACATTCCTTGCAGACCCCGCAT
TGCCCTTTGGGGGTGCCCTGGGATCCCTGGGGTAGTCCAGCTCTTCTTCATTTCCCAGCGTGGCCCTGGTTGGAAGAAGCAGCTGTCACA
GCTGCTGTAGACAGCTGTGTTCCTACAATTGGCCCAGCACCCTGGGGCACGGGAGAAGGGTGGGGACCGTTGCTGTCACTACTCAGGCTG
ACTGGGGCCTGGTCAGATTACGTATGCCCTTGGTGGTTTAGAGATAATCCAAAATCAGGGTTTGGTTTGGGGAAGAAAATCCTCCCCCTT
CCTCCCCCGCCCCGTTCCCTACCGCCTCCACTCCTGCCAGCTCATTTCCTTCAATTTCCTTTGACCTATAGGCTAAAAAAGAAAGGCTCA
TTCCAGCCACAGGGCAGCCTTCCCTGGGCCTTTGCTTCTCTAGCACAATTATGGGTTACTTCCTTTTTCTTAACAAAAAAGAATGTTTGA
TTTCCTCTGGGTGACCTTATTGTCTGTAATTGAAACCCTATTGAGAGGTGATGTCTGTGTTAGCCAATGACCCAGGTGAGCTGCTCGGGC
TTCTCTTGGTATGTCTTGTTTGGAAAAGTGGATTTCATTCATTTCTGATTGTCCAGTTAAGTGATCACCAAAGGACTGAGAATCTGGGAG
GGCAAAAAAAAAAAAAAAGTTTTTATGTGCACTTAAATTTGGGGACAATTTTATGTATCTGTGTTAAGGATATGTTTAAGAACATAATTC
TTTTGTTGCTGTTTGTTTAAGAAGCACCTTAGTTTGTTTAAGAAGCACCTTATATAGTATAATATATATTTTTTTGAAATTACATTGCTT
GTTTATCAGACAATTGAATGTAGTAATTCTGTTCTGGATTTAATTTGACTGGGTTAACATGCAAAAACCAAGGAAAAATATTTAGTTTTT
TTTTTTTTTTTTGTATACTTTTCAAGCTACCTTGTCATGTATACAGTCATTTATGCCTAAAGCCTGGTGATTATTCATTTAAATGAAGAT
CACATTTCATATCAACTTTTGTATCCACAGTAGACAAAATAGCACTAATCCAGATGCCTATTGTTGGATACTGAATGACAGACAATCTTA
TGTAGCAAAGATTATGCCTGAAAAGGAAAATTATTCAGGGCAGCTAATTTTGCTTTTACCAAAATATCAGTAGTAATATTTTTGGACAGT
AGCTAATGGGTCAGTGGGTTCTTTTTAATGTTTATACTTAGATTTTCTTTTAAAAAAATTAAAATAAAACAAAAAAAAATTTCTAGGACT
AGACGATGTAATACCAGCTAAAGCCAAACAATTATACAGTGGAAGGTTTTACATTATTCATCCAATGTGTTTCTATTCATGTTAAGATAC
TACTACATTTGAAGTGGGCAGAGAACATCAGATGATTGAAATGTTCGCCCAGGGGTCTCCAGCAACTTTGGAAATCTCTTTGTATTTTTA
CTTGAAGTGCCACTAATGGACAGCAGATATTTTCTGGCTGATGTTGGTATTGGGTGTAGGAACATGATTTAAAAAAAAACTCTTGCCTCT
GCTTTCCCCCACTCTGAGGCAAGTTAAAATGTAAAAGATGTGATTTATCTGGGGGGCTCAGGTATGGTGGGGAAGTGGATTCAGGAATCT
GGGGAATGGCAAATATATTAAGAAGAGTATTGAAAGTATTTGGAGGAAAATGGTTAATTCTGGGTGTGCACCAGGGTTCAGTAGAGTCCA
CTTCTGCCCTGGAGACCACAAATCAACTAGCTCCATTTACAGCCATTTCTAAAATGGCAGCTTCAGTTCTAGAGAAGAAAGAACAACATC
AGCAGTAAAGTCCATGGAATAGCTAGTGGTCTGTGTTTCTTTTCGCCATTGCCTAGCTTGCCGTAATGATTCTATAATGCCATCATGCAG
CAATTATGAGAGGCTAGGTCATCCAAAGAGAAGACCCTATCAATGTAGGTTGCAAAATCTAACCCCTAAGGAAGTGCAGTCTTTGATTTG
ATTTCCCTAGTAACCTTGCAGATATGTTTAACCAAGCCATAGCCCATGCCTTTTGAGGGCTGAACAAATAAGGGACTTACTGATAATTTA
CTTTTGATCACATTAAGGTGTTCTCACCTTGAAATCTTATACACTGAAATGGCCATTGATTTAGGCCACTGGCTTAGAGTACTCCTTCCC
CTGCATGACACTGATTACAAATACTTTCCTATTCATACTTTCCAATTATGAGATGGACTGTGGGTACTGGGAGTGATCACTAACACCATA
GTAATGTCTAATATTCACAGGCAGATCTGCTTGGGGAAGCTAGTTATGTGAAAGGCAAATAGAGTCATACAGTAGCTCAAAAGGCAACCA
TAATTCTCTTTGGTGCAGGTCTTGGGAGCGTGATCTAGATTACACTGCACCATTCCCAAGTTAATCCCCTGAAAACTTACTCTCAACTGG
AGCAAATGAACTTTGGTCCCAAATATCCATCTTTTCAGTAGCGTTAATTATGCTCTGTTTCCAACTGCATTTCCTTTCCAATTGAATTAA
AGTGTGGCCTCGTTTTTAGTCATTTAAAATTGTTTTCTAAGTAATTGCTGCCTCTATTATGGCACTTCAATTTTGCACTGTCTTTTGAGA
TTCAAGAAAAATTTCTATTCTTTTTTTTGCATCCAATTGTGCCTGAACTTTTAAAATATGTAAATGCTGCCATGTTCCAAACCCATCGTC
AGTGTGTGTGTTTAGAGCTGTGCACCCTAGAAACAACATATTGTCCCATGAGCAGGTGCCTGAGACACAGACCCCTTTGCATTCACAGAG
AGGTCATTGGTTATAGAGACTTGAATTAATAAGTGACATTATGCCAGTTTCTGTTCTCTCACAGGTGATAAACAATGCTTTTTGTGCACT
ACATACTCTTCAGTGTAGAGCTCTTGTTTTATGGGAAAAGGCTCAAATGCCAAATTGTGTTTGATGGATTAATATGCCCTTTTGCCGATG
CATACTATTACTGATGTGACTCGGTTTTGTCGCAGCTTTGCTTTGTTTAATGAAACACACTTGTAAACCTCTTTTGCACTTTGAAAAAGA

>53416_53416_4_MGP-ESR1_MGP_chr12_15037147_ENST00000539261_ESR1_chr6_152265308_ENST00000440973_length(amino acids)=378AA_BP=37
MQDETMKSLILLAILAALAVVTLCYESHESMESYELRIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLA
LSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSME
HPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLI
HLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSH

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MGP-ESR1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	ESR1	chr12:15037147	chr6:152265308	ENST00000206249		2	8	262_595	253.33333333333334	596.0	AKAP13
Tgene	ESR1	chr12:15037147	chr6:152265308	ENST00000338799		3	9	262_595	253.33333333333334	596.0	AKAP13
Tgene	ESR1	chr12:15037147	chr6:152265308	ENST00000440973		4	10	262_595	253.33333333333334	596.0	AKAP13
Tgene	ESR1	chr12:15037147	chr6:152265308	ENST00000443427		3	9	262_595	253.33333333333334	596.0	AKAP13
Tgene	ESR1	chr12:15037147	chr6:152265308	ENST00000456483		0	8	262_595	0	484.0	AKAP13
Tgene	ESR1	chr12:15037147	chr6:152265308	ENST00000456483		0	8	35_174	0	484.0	DDX5%3B self-association

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	ESR1	chr12:15037147	chr6:152265308	ENST00000206249		2	8	35_174	253.33333333333334	596.0	DDX5%3B self-association
Tgene	ESR1	chr12:15037147	chr6:152265308	ENST00000338799		3	9	35_174	253.33333333333334	596.0	DDX5%3B self-association
Tgene	ESR1	chr12:15037147	chr6:152265308	ENST00000440973		4	10	35_174	253.33333333333334	596.0	DDX5%3B self-association
Tgene	ESR1	chr12:15037147	chr6:152265308	ENST00000443427		3	9	35_174	253.33333333333334	596.0	DDX5%3B self-association

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for MGP-ESR1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for MGP-ESR1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source