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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MGRN1-NFATC1 (FusionGDB2 ID:53428)

Fusion Gene Summary for MGRN1-NFATC1

check button Fusion gene summary
Fusion gene informationFusion gene name: MGRN1-NFATC1
Fusion gene ID: 53428
HgeneTgene
Gene symbol

MGRN1

NFATC1

Gene ID

23295

4772

Gene namemahogunin ring finger 1nuclear factor of activated T cells 1
SynonymsRNF156NF-ATC|NF-ATc1.2|NFAT2|NFATc
Cytomap

16p13.3

18q23

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase MGRN1RING finger protein 156RING-type E3 ubiquitin transferase MGRN1mahogunin RING finger protein 1mahogunin ring finger 1, E3 ubiquitin protein ligaseprobable E3 ubiquitin-protein ligase MGRN1nuclear factor of activated T-cells, cytoplasmic 1NFAT transcription complex cytosolic componentnuclear factor of activated T-cells 'c'nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
Modification date2020031320200313
UniProtAcc

O60291

O95644

Ensembl transtripts involved in fusion geneENST00000262370, ENST00000399577, 
ENST00000415496, ENST00000586183, 
ENST00000588994, ENST00000588015, 
ENST00000590172, ENST00000253506, 
ENST00000318065, ENST00000329101, 
ENST00000397790, ENST00000427363, 
ENST00000542384, ENST00000545796, 
ENST00000586434, ENST00000587635, 
ENST00000591814, ENST00000592223, 
Fusion gene scores* DoF score11 X 9 X 9=8919 X 9 X 7=567
# samples 1711
** MAII scorelog2(17/891*10)=-2.38989068538422
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/567*10)=-2.36584521141757
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MGRN1 [Title/Abstract] AND NFATC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMGRN1(4733933)-NFATC1(77227450), # samples:1
Anticipated loss of major functional domain due to fusion event.MGRN1-NFATC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
MGRN1-NFATC1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
MGRN1-NFATC1 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMGRN1

GO:0043951

negative regulation of cAMP-mediated signaling

19737927

HgeneMGRN1

GO:0045744

negative regulation of G protein-coupled receptor signaling pathway

19737927

TgeneNFATC1

GO:0033173

calcineurin-NFAT signaling cascade

14979875

TgeneNFATC1

GO:0035556

intracellular signal transduction

14749367

TgeneNFATC1

GO:0045893

positive regulation of transcription, DNA-templated

14749367|14979875

TgeneNFATC1

GO:0045944

positive regulation of transcription by RNA polymerase II

14979875

TgeneNFATC1

GO:1905064

negative regulation of vascular smooth muscle cell differentiation

23853098


check buttonFusion gene breakpoints across MGRN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NFATC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR315396MGRN1chr16

4733933

+NFATC1chr18

77227450

+


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Fusion Gene ORF analysis for MGRN1-NFATC1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000262370ENST00000590172MGRN1chr16

4733933

+NFATC1chr18

77227450

+
5CDS-intronENST00000399577ENST00000590172MGRN1chr16

4733933

+NFATC1chr18

77227450

+
5CDS-intronENST00000415496ENST00000590172MGRN1chr16

4733933

+NFATC1chr18

77227450

+
5CDS-intronENST00000586183ENST00000590172MGRN1chr16

4733933

+NFATC1chr18

77227450

+
5CDS-intronENST00000588994ENST00000590172MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000262370ENST00000253506MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000262370ENST00000318065MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000262370ENST00000329101MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000262370ENST00000397790MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000262370ENST00000427363MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000262370ENST00000542384MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000262370ENST00000545796MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000262370ENST00000586434MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000262370ENST00000587635MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000262370ENST00000591814MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000262370ENST00000592223MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000399577ENST00000253506MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000399577ENST00000318065MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000399577ENST00000329101MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000399577ENST00000397790MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000399577ENST00000427363MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000399577ENST00000542384MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000399577ENST00000545796MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000399577ENST00000586434MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000399577ENST00000587635MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000399577ENST00000591814MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000399577ENST00000592223MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000415496ENST00000253506MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000415496ENST00000318065MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000415496ENST00000329101MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000415496ENST00000397790MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000415496ENST00000427363MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000415496ENST00000542384MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000415496ENST00000545796MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000415496ENST00000586434MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000415496ENST00000587635MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000415496ENST00000591814MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000415496ENST00000592223MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000586183ENST00000253506MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000586183ENST00000318065MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000586183ENST00000329101MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000586183ENST00000397790MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000586183ENST00000427363MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000586183ENST00000542384MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000586183ENST00000545796MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000586183ENST00000586434MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000586183ENST00000587635MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000586183ENST00000591814MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000586183ENST00000592223MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000588994ENST00000253506MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000588994ENST00000318065MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000588994ENST00000329101MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000588994ENST00000397790MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000588994ENST00000427363MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000588994ENST00000542384MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000588994ENST00000545796MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000588994ENST00000586434MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000588994ENST00000587635MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000588994ENST00000591814MGRN1chr16

4733933

+NFATC1chr18

77227450

+
Frame-shiftENST00000588994ENST00000592223MGRN1chr16

4733933

+NFATC1chr18

77227450

+
intron-3CDSENST00000588015ENST00000253506MGRN1chr16

4733933

+NFATC1chr18

77227450

+
intron-3CDSENST00000588015ENST00000318065MGRN1chr16

4733933

+NFATC1chr18

77227450

+
intron-3CDSENST00000588015ENST00000329101MGRN1chr16

4733933

+NFATC1chr18

77227450

+
intron-3CDSENST00000588015ENST00000397790MGRN1chr16

4733933

+NFATC1chr18

77227450

+
intron-3CDSENST00000588015ENST00000427363MGRN1chr16

4733933

+NFATC1chr18

77227450

+
intron-3CDSENST00000588015ENST00000542384MGRN1chr16

4733933

+NFATC1chr18

77227450

+
intron-3CDSENST00000588015ENST00000545796MGRN1chr16

4733933

+NFATC1chr18

77227450

+
intron-3CDSENST00000588015ENST00000586434MGRN1chr16

4733933

+NFATC1chr18

77227450

+
intron-3CDSENST00000588015ENST00000587635MGRN1chr16

4733933

+NFATC1chr18

77227450

+
intron-3CDSENST00000588015ENST00000591814MGRN1chr16

4733933

+NFATC1chr18

77227450

+
intron-3CDSENST00000588015ENST00000592223MGRN1chr16

4733933

+NFATC1chr18

77227450

+
intron-intronENST00000588015ENST00000590172MGRN1chr16

4733933

+NFATC1chr18

77227450

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MGRN1-NFATC1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MGRN1-NFATC1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:4733933/:77227450)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MGRN1

O60291

NFATC1

O95644

FUNCTION: E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity). {ECO:0000250|UniProtKB:Q9D074, ECO:0000269|PubMed:17229889, ECO:0000269|PubMed:19703557, ECO:0000269|PubMed:19737927}.FUNCTION: Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells (PubMed:10358178). Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity). {ECO:0000250|UniProtKB:O88942, ECO:0000269|PubMed:10358178}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MGRN1-NFATC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MGRN1-NFATC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MGRN1-NFATC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MGRN1-NFATC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource