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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MGRN1-PXN (FusionGDB2 ID:53430)

Fusion Gene Summary for MGRN1-PXN

check button Fusion gene summary
Fusion gene informationFusion gene name: MGRN1-PXN
Fusion gene ID: 53430
HgeneTgene
Gene symbol

MGRN1

PXN

Gene ID

23295

7837

Gene namemahogunin ring finger 1peroxidasin
SynonymsRNF156ASGD7|COPOA|D2S448|D2S448E|MG50|PRG2|PXN|VPO
Cytomap

16p13.3

2p25.3

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase MGRN1RING finger protein 156RING-type E3 ubiquitin transferase MGRN1mahogunin RING finger protein 1mahogunin ring finger 1, E3 ubiquitin protein ligaseprobable E3 ubiquitin-protein ligase MGRN1peroxidasin homologmelanoma-associated antigen MG50p53-responsive gene 2 proteinvascular peroxidase 1
Modification date2020031320200313
UniProtAcc

O60291

.
Ensembl transtripts involved in fusion geneENST00000262370, ENST00000399577, 
ENST00000415496, ENST00000586183, 
ENST00000588015, ENST00000588994, 
ENST00000228307, ENST00000267257, 
ENST00000397506, ENST00000424649, 
ENST00000458477, ENST00000536957, 
ENST00000538144, 
Fusion gene scores* DoF score11 X 9 X 9=8919 X 9 X 2=162
# samples 179
** MAII scorelog2(17/891*10)=-2.38989068538422
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/162*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MGRN1 [Title/Abstract] AND PXN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMGRN1(4740612)-PXN(120654005), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMGRN1

GO:0043951

negative regulation of cAMP-mediated signaling

19737927

HgeneMGRN1

GO:0045744

negative regulation of G protein-coupled receptor signaling pathway

19737927

TgenePXN

GO:0030198

extracellular matrix organization

19590037

TgenePXN

GO:0042744

hydrogen peroxide catabolic process

18929642

TgenePXN

GO:0055114

oxidation-reduction process

18929642


check buttonFusion gene breakpoints across MGRN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PXN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABF762439MGRN1chr16

4740612

-PXNchr12

120654005

+


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Fusion Gene ORF analysis for MGRN1-PXN

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000262370ENST00000228307MGRN1chr16

4740612

-PXNchr12

120654005

+
3UTR-intronENST00000262370ENST00000267257MGRN1chr16

4740612

-PXNchr12

120654005

+
3UTR-intronENST00000262370ENST00000397506MGRN1chr16

4740612

-PXNchr12

120654005

+
3UTR-intronENST00000262370ENST00000424649MGRN1chr16

4740612

-PXNchr12

120654005

+
3UTR-intronENST00000262370ENST00000458477MGRN1chr16

4740612

-PXNchr12

120654005

+
3UTR-intronENST00000262370ENST00000536957MGRN1chr16

4740612

-PXNchr12

120654005

+
3UTR-intronENST00000262370ENST00000538144MGRN1chr16

4740612

-PXNchr12

120654005

+
3UTR-intronENST00000399577ENST00000228307MGRN1chr16

4740612

-PXNchr12

120654005

+
3UTR-intronENST00000399577ENST00000267257MGRN1chr16

4740612

-PXNchr12

120654005

+
3UTR-intronENST00000399577ENST00000397506MGRN1chr16

4740612

-PXNchr12

120654005

+
3UTR-intronENST00000399577ENST00000424649MGRN1chr16

4740612

-PXNchr12

120654005

+
3UTR-intronENST00000399577ENST00000458477MGRN1chr16

4740612

-PXNchr12

120654005

+
3UTR-intronENST00000399577ENST00000536957MGRN1chr16

4740612

-PXNchr12

120654005

+
3UTR-intronENST00000399577ENST00000538144MGRN1chr16

4740612

-PXNchr12

120654005

+
3UTR-intronENST00000415496ENST00000228307MGRN1chr16

4740612

-PXNchr12

120654005

+
3UTR-intronENST00000415496ENST00000267257MGRN1chr16

4740612

-PXNchr12

120654005

+
3UTR-intronENST00000415496ENST00000397506MGRN1chr16

4740612

-PXNchr12

120654005

+
3UTR-intronENST00000415496ENST00000424649MGRN1chr16

4740612

-PXNchr12

120654005

+
3UTR-intronENST00000415496ENST00000458477MGRN1chr16

4740612

-PXNchr12

120654005

+
3UTR-intronENST00000415496ENST00000536957MGRN1chr16

4740612

-PXNchr12

120654005

+
3UTR-intronENST00000415496ENST00000538144MGRN1chr16

4740612

-PXNchr12

120654005

+
intron-intronENST00000586183ENST00000228307MGRN1chr16

4740612

-PXNchr12

120654005

+
intron-intronENST00000586183ENST00000267257MGRN1chr16

4740612

-PXNchr12

120654005

+
intron-intronENST00000586183ENST00000397506MGRN1chr16

4740612

-PXNchr12

120654005

+
intron-intronENST00000586183ENST00000424649MGRN1chr16

4740612

-PXNchr12

120654005

+
intron-intronENST00000586183ENST00000458477MGRN1chr16

4740612

-PXNchr12

120654005

+
intron-intronENST00000586183ENST00000536957MGRN1chr16

4740612

-PXNchr12

120654005

+
intron-intronENST00000586183ENST00000538144MGRN1chr16

4740612

-PXNchr12

120654005

+
intron-intronENST00000588015ENST00000228307MGRN1chr16

4740612

-PXNchr12

120654005

+
intron-intronENST00000588015ENST00000267257MGRN1chr16

4740612

-PXNchr12

120654005

+
intron-intronENST00000588015ENST00000397506MGRN1chr16

4740612

-PXNchr12

120654005

+
intron-intronENST00000588015ENST00000424649MGRN1chr16

4740612

-PXNchr12

120654005

+
intron-intronENST00000588015ENST00000458477MGRN1chr16

4740612

-PXNchr12

120654005

+
intron-intronENST00000588015ENST00000536957MGRN1chr16

4740612

-PXNchr12

120654005

+
intron-intronENST00000588015ENST00000538144MGRN1chr16

4740612

-PXNchr12

120654005

+
intron-intronENST00000588994ENST00000228307MGRN1chr16

4740612

-PXNchr12

120654005

+
intron-intronENST00000588994ENST00000267257MGRN1chr16

4740612

-PXNchr12

120654005

+
intron-intronENST00000588994ENST00000397506MGRN1chr16

4740612

-PXNchr12

120654005

+
intron-intronENST00000588994ENST00000424649MGRN1chr16

4740612

-PXNchr12

120654005

+
intron-intronENST00000588994ENST00000458477MGRN1chr16

4740612

-PXNchr12

120654005

+
intron-intronENST00000588994ENST00000536957MGRN1chr16

4740612

-PXNchr12

120654005

+
intron-intronENST00000588994ENST00000538144MGRN1chr16

4740612

-PXNchr12

120654005

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MGRN1-PXN


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MGRN1-PXN


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:4740612/:120654005)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MGRN1

O60291

.
FUNCTION: E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity). {ECO:0000250|UniProtKB:Q9D074, ECO:0000269|PubMed:17229889, ECO:0000269|PubMed:19703557, ECO:0000269|PubMed:19737927}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MGRN1-PXN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MGRN1-PXN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MGRN1-PXN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MGRN1-PXN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource