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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MIB1-HLTF (FusionGDB2 ID:53489)

Fusion Gene Summary for MIB1-HLTF

Fusion gene summary

Fusion gene information	Fusion gene name: MIB1-HLTF
	Fusion gene ID: 53489
		Hgene	Tgene
	Gene symbol	MIB1	HLTF
	Gene ID	57534	6596
	Gene name	mindbomb E3 ubiquitin protein ligase 1	helicase like transcription factor
	Synonyms	DIP-1\|DIP1\|LVNC7\|MIB\|ZZANK2\|ZZZ6	HIP116\|HIP116A\|HLTF1\|RNF80\|SMARCA3\|SNF2L3\|ZBU1
	Cytomap	18q11.2	3q24
	Type of gene	protein-coding	protein-coding
	Description	E3 ubiquitin-protein ligase MIB1DAPK-interacting protein 1RING-type E3 ubiquitin transferase MIB1ubiquitin ligase mind bombzinc finger ZZ type with ankyrin repeat domain protein 2	helicase-like transcription factorDNA-binding protein/plasminogen activator inhibitor-1 regulatorRING finger protein 80RING-type E3 ubiquitin transferase HLTFSNF2-like 3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfa
	Modification date	20200313	20200322
	UniProtAcc	Q86YT6	Q14527
	Ensembl transtripts involved in fusion gene	ENST00000578646, ENST00000261537,	ENST00000310053, ENST00000392912, ENST00000465259, ENST00000494055, ENST00000481663,
Fusion gene scores	* DoF score	11 X 12 X 7=924	5 X 5 X 3=75
	# samples	14	5
	** MAII score	log2(14/924*10)=-2.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MIB1 [Title/Abstract] AND HLTF [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MIB1(19353689)-HLTF(148802676), # samples:1
Anticipated loss of major functional domain due to fusion event.	MIB1-HLTF seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. MIB1-HLTF seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MIB1	GO:0006511	ubiquitin-dependent protein catabolic process	23615451

Fusion gene breakpoints across MIB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across HLTF (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SARC	TCGA-SI-A71Q-01A	MIB1	chr18	19353689	-	HLTF	chr3	148802676	-

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Fusion Gene ORF analysis for MIB1-HLTF

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000578646	ENST00000310053	MIB1	chr18	19353689	-	HLTF	chr3	148802676	-
3UTR-3CDS	ENST00000578646	ENST00000392912	MIB1	chr18	19353689	-	HLTF	chr3	148802676	-
3UTR-3CDS	ENST00000578646	ENST00000465259	MIB1	chr18	19353689	-	HLTF	chr3	148802676	-
3UTR-3CDS	ENST00000578646	ENST00000494055	MIB1	chr18	19353689	-	HLTF	chr3	148802676	-
3UTR-5UTR	ENST00000578646	ENST00000481663	MIB1	chr18	19353689	-	HLTF	chr3	148802676	-
5CDS-5UTR	ENST00000261537	ENST00000481663	MIB1	chr18	19353689	-	HLTF	chr3	148802676	-
Frame-shift	ENST00000261537	ENST00000310053	MIB1	chr18	19353689	-	HLTF	chr3	148802676	-
Frame-shift	ENST00000261537	ENST00000465259	MIB1	chr18	19353689	-	HLTF	chr3	148802676	-
In-frame	ENST00000261537	ENST00000392912	MIB1	chr18	19353689	-	HLTF	chr3	148802676	-
In-frame	ENST00000261537	ENST00000494055	MIB1	chr18	19353689	-	HLTF	chr3	148802676	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000261537	MIB1	chr18	19353689	-	ENST00000392912	HLTF	chr3	148802676	-	4608	900	844	3909	1021
ENST00000261537	MIB1	chr18	19353689	-	ENST00000494055	HLTF	chr3	148802676	-	4295	900	844	3909	1021

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000261537	ENST00000392912	MIB1	chr18	19353689	-	HLTF	chr3	148802676	-	0.00036007	0.99963987
ENST00000261537	ENST00000494055	MIB1	chr18	19353689	-	HLTF	chr3	148802676	-	0.000387855	0.99961215

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Fusion Genomic Features for MIB1-HLTF

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MIB1-HLTF

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:19353689/chr3:148802676)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MIB1 Q86YT6	HLTF Q14527
FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation. {ECO:0000250, ECO:0000269\|PubMed:24121310}.	FUNCTION: Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA. {ECO:0000250, ECO:0000269\|PubMed:10391891, ECO:0000269\|PubMed:18316726, ECO:0000269\|PubMed:18719106, ECO:0000269\|PubMed:7876228, ECO:0000269\|PubMed:8672239, ECO:0000269\|PubMed:9126292}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MIB1

chr18:19353689

chr3:148802676

ENST00000261537

6_74

212

1007.0

Domain

MIB/HERC2 1

Hgene

MIB1

chr18:19353689

chr3:148802676

ENST00000261537

79_126

212

1007.0

Zinc finger

ZZ-type

Tgene

HLTF

chr18:19353689

chr3:148802676

ENST00000310053

38_287

1010.0

DNA binding

Tgene

HLTF

chr18:19353689

chr3:148802676

ENST00000392912

38_287

1161.6666666666667

DNA binding

Tgene

HLTF

chr18:19353689

chr3:148802676

ENST00000465259

38_287

1009.0

DNA binding

Tgene

HLTF

chr18:19353689

chr3:148802676

ENST00000494055

38_287

1040.6666666666667

DNA binding

Tgene

HLTF

chr18:19353689

chr3:148802676

ENST00000310053

435_606

1010.0

Domain

Helicase ATP-binding

Tgene

HLTF

chr18:19353689

chr3:148802676

ENST00000310053

837_996

1010.0

Domain

Helicase C-terminal

Tgene

HLTF

chr18:19353689

chr3:148802676

ENST00000392912

435_606

1161.6666666666667

Domain

Helicase ATP-binding

Tgene

HLTF

chr18:19353689

chr3:148802676

ENST00000392912

837_996

1161.6666666666667

Domain

Helicase C-terminal

Tgene

HLTF

chr18:19353689

chr3:148802676

ENST00000465259

435_606

1009.0

Domain

Helicase ATP-binding

Tgene

HLTF

chr18:19353689

chr3:148802676

ENST00000465259

837_996

1009.0

Domain

Helicase C-terminal

Tgene

HLTF

chr18:19353689

chr3:148802676

ENST00000494055

435_606

1040.6666666666667

Domain

Helicase ATP-binding

Tgene

HLTF

chr18:19353689

chr3:148802676

ENST00000494055

837_996

1040.6666666666667

Domain

Helicase C-terminal

Tgene

HLTF

chr18:19353689

chr3:148802676

ENST00000310053

557_560

1010.0

Motif

Note=DEGH box

Tgene

HLTF

chr18:19353689

chr3:148802676

ENST00000392912

557_560

1161.6666666666667

Motif

Note=DEGH box

Tgene

HLTF

chr18:19353689

chr3:148802676

ENST00000465259

557_560

1009.0

Motif

Note=DEGH box

Tgene

HLTF

chr18:19353689

chr3:148802676

ENST00000494055

557_560

1040.6666666666667

Motif

Note=DEGH box

Tgene

HLTF

chr18:19353689

chr3:148802676

ENST00000310053

294_301

1010.0

Nucleotide binding

ATP

Tgene

HLTF

chr18:19353689

chr3:148802676

ENST00000392912

294_301

1161.6666666666667

Nucleotide binding

ATP

Tgene

HLTF

chr18:19353689

chr3:148802676

ENST00000465259

294_301

1009.0

Nucleotide binding

ATP

Tgene

HLTF

chr18:19353689

chr3:148802676

ENST00000494055

294_301

1040.6666666666667

Nucleotide binding

ATP

Tgene

HLTF

chr18:19353689

chr3:148802676

ENST00000310053

760_801

1010.0

Zinc finger

RING-type

Tgene

HLTF

chr18:19353689

chr3:148802676

ENST00000392912

760_801

1161.6666666666667

Zinc finger

RING-type

Tgene

HLTF

chr18:19353689

chr3:148802676

ENST00000465259

760_801

1009.0

Zinc finger

RING-type

Tgene

HLTF

chr18:19353689

chr3:148802676

ENST00000494055

760_801

1040.6666666666667

Zinc finger

RING-type

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MIB1

chr18:19353689

chr3:148802676

ENST00000261537

935_962

212

1007.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

MIB1

chr18:19353689

chr3:148802676

ENST00000261537

143_221

212

1007.0

Domain

MIB/HERC2 2

Hgene

MIB1

chr18:19353689

chr3:148802676

ENST00000261537

430_460

212

1007.0

Repeat

Note=ANK 1

Hgene

MIB1

chr18:19353689

chr3:148802676

ENST00000261537

463_492

212

1007.0

Repeat

Note=ANK 2

Hgene

MIB1

chr18:19353689

chr3:148802676

ENST00000261537

496_525

212

1007.0

Repeat

Note=ANK 3

Hgene

MIB1

chr18:19353689

chr3:148802676

ENST00000261537

529_558

212

1007.0

Repeat

Note=ANK 4

Hgene

MIB1

chr18:19353689

chr3:148802676

ENST00000261537

562_591

212

1007.0

Repeat

Note=ANK 5

Hgene

MIB1

chr18:19353689

chr3:148802676

ENST00000261537

595_627

212

1007.0

Repeat

Note=ANK 6

Hgene

MIB1

chr18:19353689

chr3:148802676

ENST00000261537

631_661

212

1007.0

Repeat

Note=ANK 7

Hgene

MIB1

chr18:19353689

chr3:148802676

ENST00000261537

665_694

212

1007.0

Repeat

Note=ANK 8

Hgene

MIB1

chr18:19353689

chr3:148802676

ENST00000261537

698_729

212

1007.0

Repeat

Note=ANK 9

Hgene

MIB1

chr18:19353689

chr3:148802676

ENST00000261537

819_854

212

1007.0

Zinc finger

RING-type 1

Hgene

MIB1

chr18:19353689

chr3:148802676

ENST00000261537

866_901

212

1007.0

Zinc finger

RING-type 2

Hgene

MIB1

chr18:19353689

chr3:148802676

ENST00000261537

963_996

212

1007.0

Zinc finger

RING-type 3

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Fusion Gene Sequence for MIB1-HLTF

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>53489_53489_1_MIB1-HLTF_MIB1_chr18_19353689_ENST00000261537_HLTF_chr3_148802676_ENST00000392912_length(transcript)=4608nt_BP=900nt
TGCCCGCTCTCCGCCGCCGCCTCCGAGCAGCCGCGGGCCGCCCTCCACTCCGAGCGGGGGGCGCGGCGGCGACAGCTGGGCAGCGGCTTT
GGGCTCCGCGGGGACCGCGCCGCCGCCCCCGTGAGTTATTCTCACGTCCCCCGGGGCTCGCTGCCGCCCCCGCCGACGCCTAGAGTCCGG
CCCGGGCCCAACTCCCTCACGGGCCCCCCGGCGGCAGCGGCGGCGGCGGCGGCGGCAGCGGCGGAGCCCACCGCCCGGGCCCCGATGAGT
AACTCCCGGAATAACCGGGTGATGGTGGAAGGGGTTGGCGCTCGGGTAGTGCGCGGCCCGGACTGGAAGTGGGGGAAGCAGGACGGCGGC
GAGGGCCATGTGGGCACCGTCCGGAGCTTCGAGAGCCCCGAGGAGGTGGTGGTAGTGTGGGACAACGGCACAGCTGCCAACTACCGCTGC
TCCGGGGCTTACGACCTCCGCATCCTGGACAGCGCGCCCACCGGCATCAAGCATGATGGAACCATGTGTGATACCTGCCGCCAGCAACCA
ATCATTGGCATTCGATGGAAGTGTGCAGAGTGTACAAATTATGATTTGTGCACAGTGTGTTATCATGGAGATAAACATCATTTAAGACAT
CGCTTTTACCGAATTACTACACCGGGAAGTGAGAGGGTTCTGTTAGAGTCTCGTAGGAAATCTAAGAAGATTACAGCCAGAGGAATCTTT
GCAGGTGCCAGAGTGGTGCGAGGAGTGGACTGGCAGTGGGAAGATCAAGATGGAGGAAATGGACGTAGGGGAAAGGTAACAGAAATCCAG
GACTGGAGTGCATCAAGCCCACATAGCGCAGCATATGTCCTCTGGGATAATGGTGCTAAGAACCTTTACAGAGTTGGCTTTGAGGGCATG
GGATCCAGTTTGGAAGTACTTGCAGACTGTCCAGTATGGAGTTCATGGAAATTTTCCACGCCTCTCATATCCAACTTTCTTTCCACGTTT
TGAATTCCAAGATGTTATCCCTCCAGATGACTTTCTAACTAGTGATGAAGAAGTAGATTCCGTTTTATTTGGAAGTTTGAGAGGTCATGT
GGTTGGACTACGCTATTACACGGGAGTAGTTAATAATAATGAAATGGTTGCATTACAACGAGATCCTAATAACCCTTATGATAAGAATGC
AATTAAAGTAAACAATGTGAATGGAAATCAAGTTGGCCATTTAAAGAAAGAGCTTGCAGGTGCTTTGGCCTATATCATGGACAACAAATT
GGCACAAATTGAAGGGGTAGTTCCTTTTGGTGCAAACAATGCTTTTACCATGCCTCTGCATATGACTTTTTGGGGAAAAGAAGAAAATAG
AAAAGCGGTTTCAGATCAGTTGAAGAAACATGGATTTAAATTGGGTCCTGCACCAAAAACTTTAGGATTCAATTTGGAAAGTGGTTGGGG
CTCTGGAAGAGCTGGACCAAGCTATAGTATGCCAGTGCATGCTGCAGTACAGATGACAACTGAACAGCTTAAAACAGAATTTGACAAATT
GTTTGAAGATTTAAAAGAAGATGATAAAACCCATGAAATGGAACCAGCTGAGGCTATTGAAACACCACTGCTTCCACATCAAAAACAAGC
TCTAGCTTGGATGGTGTCACGGGAAAATAGCAAAGAACTTCCACCATTCTGGGAACAGCGAAATGACTTATACTATAACACAATAACAAA
TTTTTCTGAGAAGGACCGACCAGAAAATGTCCATGGAGGAATTTTAGCTGATGATATGGGTTTGGGTAAAACTCTTACGGCCATTGCAGT
AATCCTTACCAACTTCCATGATGGCAGACCTCTTCCTATTGAAAGAGTTAAAAAGAATCTACTGAAGAAGGAATATAATGTTAACGATGA
CTCTATGAAACTTGGAGGAAACAATACCAGTGAAAAGGCAGATGGACTAAGCAAAGACGCATCTAGATGTAGTGAACAACCCAGTATTTC
AGATATCAAGGAGAAGAGTAAGTTTCGCATGTCAGAATTGTCTAGCTCCCGCCCCAAAAGAAGAAAAACTGCTGTCCAGTACATAGAAAG
CAGTGATTCAGAGGAAATTGAAACAAGTGAATTGCCGCAGAAAATGAAAGGCAAACTGAAAAATGTACAGTCTGAAACTAAAGGCAGGGC
GAAAGCAGGATCTTCTAAGGTTATAGAAGATGTGGCATTTGCATGTGCATTAACTTCATCTGTTCCTACAACAAAAAAGAAAATGTTGAA
AAAGGGAGCTTGTGCAGTGGAGGGGTCAAAGAAAACTGATGTTGAGGAGAGACCAAGAACAACACTGATCATCTGTCCGCTTTCTGTGTT
AAGCAACTGGATTGACCAGTTTGGACAACATATAAAATCAGATGTACACTTGAATTTTTATGTTTATTATGGTCCTGATCGTATTAGAGA
ACCGGCCTTACTTTCAAAACAGGATATTGTTTTGACTACGTATAATATTTTAACTCATGACTATGGAACTAAAGGAGATAGTCCATTACA
TAGCATAAGGTGGCTAAGAGTGATCCTGGATGAAGGACATGCCATACGAAATCCAAATGCTCAGCAGACAAAAGCTGTACTTGACTTAGA
ATCAGAAAGAAGATGGGTTTTGACAGGTACTCCAATCCAGAATTCTTTAAAGGACTTGTGGTCTCTTCTTTCCTTTTTAAAACTTAAACC
ATTTATTGATAGAGAATGGTGGCATAGAACAATACAGCGTCCTGTCACAATGGGAGATGAAGGAGGACTTAGGCGTTTACAGTCCCTAAT
TAAAAATATTACACTTAGAAGAACAAAGACAAGCAAAATTAAAGGAAAACCTGTTTTGGAGTTACCAGAACGTAAAGTATTTATTCAGCA
CATTACACTTTCAGATGAAGAGAGAAAGATTTATCAGTCTGTGAAAAATGAAGGCAGAGCCACTATTGGAAGGTATTTTAATGAAGGGAC
TGTCCTGGCACATTATGCAGATGTCCTGGGTCTTTTGCTTAGACTGCGGCAAATTTGTTGCCATACTTACCTTCTTACAAATGCAGTGTC
TTCCAATGGCCCCTCAGGAAATGATACACCTGAAGAACTGAGAAAGAAGTTAATAAGGAAGATGAAGTTAATTCTGAGCTCAGGTTCAGA
TGAGGAATGTGCAATTTGCCTGGATTCTTTAACAGTTCCTGTGATAACACATTGTGCACATGTATTTTGTAAACCCTGTATTTGCCAAGT
CATTCAGAATGAGCAGCCACATGCTAAATGCCCTTTATGCAGAAATGATATACATGAAGATAATTTATTAGAATGTCCTCCAGAAGAATT
AGCACGTGACAGTGAGAAAAAGTCTGATATGGAATGGACATCCAGTTCAAAGATTAATGCGCTAATGCACGCATTGACTGACTTAAGAAA
GAAGAATCCCAACATAAAAAGTTTGGTTGTTTCTCAGTTTACAACATTCCTGTCTTTAATAGAAATACCACTTAAAGCCTCTGGATTTGT
GTTTACTCGTTTGGATGGTTCCATGGCCCAAAAGAAAAGAGTTGAATCAATTCAGTGTTTTCAAAACACTGAAGCAGGATCTCCAACTAT
AATGCTTCTGTCCTTAAAAGCAGGTGGAGTTGGTTTGAATCTGTCTGCAGCTTCTCGAGTGTTTTTAATGGATCCAGCCTGGAATCCTGC
TGCTGAAGATCAGTGCTTTGACAGATGCCATAGACTTGGTCAGAAGCAAGAAGTTATCATCACAAAATTCATTGTAAAGGACTCTGTTGA
AGAAAATATGCTGAAAATACAAAACAAAAAGAGAGAACTTGCAGCAGGAGCCTTTGGAACTAAAAAACCAAATGCTGACGAAATGAAACA
AGCCAAAATTAATGAAATCAGAACATTAATTGACTTATAATTTGTGGGATTTTAGTAAGAAGACTACTATATGTGAGAGGCGTGATATCT
GGATGGAAGTTGGGCTGGATGATCTCCAAAGTCGTTTCAACTCTTAAAGACATCTTAATCCTGAATGTAAACAATTGTTATGTGTTTAGA
ATCAGAATTTGATTTTGAACTTGAGTAATTCATCCTTACAGCTATCTGTAGAATTAGTCATCTTTTTTCTTTTCTTTTTTTTTTACTTTT
TTGTTAATAAGCAAACTTATTTGCTGCAGAATTTGGGTTGACTCCTGAGCATATTTAAAACAAAGAAGCTAGAAATTTAGCAGTCAGATT
AGGTAGGTGGTTTTATTTCAAAGGGAAACTTTAATCCAAAGAAAGATTAATTACTCTAACAAACAAGAGAAGCTTCATGTTTGATGATAC
AGATTTAAGAATACCTGAGACTTAAGAGTGTTGGAAGTCATTTGATAGAAAGATGAGATCGGAGACAATGTTGTGTTATAGGGCACACAT
TGAAGGTATATGCCAAATCTCTCACCAGATAAGTCCTTTTCTCCCTGTGCCGTTTTCTTGCTCAAAGGGAACAGTGAATTAGCCAGCTAG
AATCTTCCTGGTCCCTTTTTGAGGCAGTAGCAGGTAAGGAAAGGGCTGATTTTCATCAAAACCAAGACCTTTCTGCAGGGATGATAGTGG

>53489_53489_1_MIB1-HLTF_MIB1_chr18_19353689_ENST00000261537_HLTF_chr3_148802676_ENST00000392912_length(amino acids)=1021AA_BP=19
MSSGIMVLRTFTELALRAWDPVWKYLQTVQYGVHGNFPRLSYPTFFPRFEFQDVIPPDDFLTSDEEVDSVLFGSLRGHVVGLRYYTGVVN
NNEMVALQRDPNNPYDKNAIKVNNVNGNQVGHLKKELAGALAYIMDNKLAQIEGVVPFGANNAFTMPLHMTFWGKEENRKAVSDQLKKHG
FKLGPAPKTLGFNLESGWGSGRAGPSYSMPVHAAVQMTTEQLKTEFDKLFEDLKEDDKTHEMEPAEAIETPLLPHQKQALAWMVSRENSK
ELPPFWEQRNDLYYNTITNFSEKDRPENVHGGILADDMGLGKTLTAIAVILTNFHDGRPLPIERVKKNLLKKEYNVNDDSMKLGGNNTSE
KADGLSKDASRCSEQPSISDIKEKSKFRMSELSSSRPKRRKTAVQYIESSDSEEIETSELPQKMKGKLKNVQSETKGRAKAGSSKVIEDV
AFACALTSSVPTTKKKMLKKGACAVEGSKKTDVEERPRTTLIICPLSVLSNWIDQFGQHIKSDVHLNFYVYYGPDRIREPALLSKQDIVL
TTYNILTHDYGTKGDSPLHSIRWLRVILDEGHAIRNPNAQQTKAVLDLESERRWVLTGTPIQNSLKDLWSLLSFLKLKPFIDREWWHRTI
QRPVTMGDEGGLRRLQSLIKNITLRRTKTSKIKGKPVLELPERKVFIQHITLSDEERKIYQSVKNEGRATIGRYFNEGTVLAHYADVLGL
LLRLRQICCHTYLLTNAVSSNGPSGNDTPEELRKKLIRKMKLILSSGSDEECAICLDSLTVPVITHCAHVFCKPCICQVIQNEQPHAKCP
LCRNDIHEDNLLECPPEELARDSEKKSDMEWTSSSKINALMHALTDLRKKNPNIKSLVVSQFTTFLSLIEIPLKASGFVFTRLDGSMAQK
KRVESIQCFQNTEAGSPTIMLLSLKAGGVGLNLSAASRVFLMDPAWNPAAEDQCFDRCHRLGQKQEVIITKFIVKDSVEENMLKIQNKKR

--------------------------------------------------------------
>53489_53489_2_MIB1-HLTF_MIB1_chr18_19353689_ENST00000261537_HLTF_chr3_148802676_ENST00000494055_length(transcript)=4295nt_BP=900nt
TGCCCGCTCTCCGCCGCCGCCTCCGAGCAGCCGCGGGCCGCCCTCCACTCCGAGCGGGGGGCGCGGCGGCGACAGCTGGGCAGCGGCTTT
GGGCTCCGCGGGGACCGCGCCGCCGCCCCCGTGAGTTATTCTCACGTCCCCCGGGGCTCGCTGCCGCCCCCGCCGACGCCTAGAGTCCGG
CCCGGGCCCAACTCCCTCACGGGCCCCCCGGCGGCAGCGGCGGCGGCGGCGGCGGCAGCGGCGGAGCCCACCGCCCGGGCCCCGATGAGT
AACTCCCGGAATAACCGGGTGATGGTGGAAGGGGTTGGCGCTCGGGTAGTGCGCGGCCCGGACTGGAAGTGGGGGAAGCAGGACGGCGGC
GAGGGCCATGTGGGCACCGTCCGGAGCTTCGAGAGCCCCGAGGAGGTGGTGGTAGTGTGGGACAACGGCACAGCTGCCAACTACCGCTGC
TCCGGGGCTTACGACCTCCGCATCCTGGACAGCGCGCCCACCGGCATCAAGCATGATGGAACCATGTGTGATACCTGCCGCCAGCAACCA
ATCATTGGCATTCGATGGAAGTGTGCAGAGTGTACAAATTATGATTTGTGCACAGTGTGTTATCATGGAGATAAACATCATTTAAGACAT
CGCTTTTACCGAATTACTACACCGGGAAGTGAGAGGGTTCTGTTAGAGTCTCGTAGGAAATCTAAGAAGATTACAGCCAGAGGAATCTTT
GCAGGTGCCAGAGTGGTGCGAGGAGTGGACTGGCAGTGGGAAGATCAAGATGGAGGAAATGGACGTAGGGGAAAGGTAACAGAAATCCAG
GACTGGAGTGCATCAAGCCCACATAGCGCAGCATATGTCCTCTGGGATAATGGTGCTAAGAACCTTTACAGAGTTGGCTTTGAGGGCATG
GGATCCAGTTTGGAAGTACTTGCAGACTGTCCAGTATGGAGTTCATGGAAATTTTCCACGCCTCTCATATCCAACTTTCTTTCCACGTTT
TGAATTCCAAGATGTTATCCCTCCAGATGACTTTCTAACTAGTGATGAAGAAGTAGATTCCGTTTTATTTGGAAGTTTGAGAGGTCATGT
GGTTGGACTACGCTATTACACGGGAGTAGTTAATAATAATGAAATGGTTGCATTACAACGAGATCCTAATAACCCTTATGATAAGAATGC
AATTAAAGTAAACAATGTGAATGGAAATCAAGTTGGCCATTTAAAGAAAGAGCTTGCAGGTGCTTTGGCCTATATCATGGACAACAAATT
GGCACAAATTGAAGGGGTAGTTCCTTTTGGTGCAAACAATGCTTTTACCATGCCTCTGCATATGACTTTTTGGGGAAAAGAAGAAAATAG
AAAAGCGGTTTCAGATCAGTTGAAGAAACATGGATTTAAATTGGGTCCTGCACCAAAAACTTTAGGATTCAATTTGGAAAGTGGTTGGGG
CTCTGGAAGAGCTGGACCAAGCTATAGTATGCCAGTGCATGCTGCAGTACAGATGACAACTGAACAGCTTAAAACAGAATTTGACAAATT
GTTTGAAGATTTAAAAGAAGATGATAAAACCCATGAAATGGAACCAGCTGAGGCTATTGAAACACCACTGCTTCCACATCAAAAACAAGC
TCTAGCTTGGATGGTGTCACGGGAAAATAGCAAAGAACTTCCACCATTCTGGGAACAGCGAAATGACTTATACTATAACACAATAACAAA
TTTTTCTGAGAAGGACCGACCAGAAAATGTCCATGGAGGAATTTTAGCTGATGATATGGGTTTGGGTAAAACTCTTACGGCCATTGCAGT
AATCCTTACCAACTTCCATGATGGCAGACCTCTTCCTATTGAAAGAGTTAAAAAGAATCTACTGAAGAAGGAATATAATGTTAACGATGA
CTCTATGAAACTTGGAGGAAACAATACCAGTGAAAAGGCAGATGGACTAAGCAAAGACGCATCTAGATGTAGTGAACAACCCAGTATTTC
AGATATCAAGGAGAAGAGTAAGTTTCGCATGTCAGAATTGTCTAGCTCCCGCCCCAAAAGAAGAAAAACTGCTGTCCAGTACATAGAAAG
CAGTGATTCAGAGGAAATTGAAACAAGTGAATTGCCGCAGAAAATGAAAGGCAAACTGAAAAATGTACAGTCTGAAACTAAAGGCAGGGC
GAAAGCAGGATCTTCTAAGGTTATAGAAGATGTGGCATTTGCATGTGCATTAACTTCATCTGTTCCTACAACAAAAAAGAAAATGTTGAA
AAAGGGAGCTTGTGCAGTGGAGGGGTCAAAGAAAACTGATGTTGAGGAGAGACCAAGAACAACACTGATCATCTGTCCGCTTTCTGTGTT
AAGCAACTGGATTGACCAGTTTGGACAACATATAAAATCAGATGTACACTTGAATTTTTATGTTTATTATGGTCCTGATCGTATTAGAGA
ACCGGCCTTACTTTCAAAACAGGATATTGTTTTGACTACGTATAATATTTTAACTCATGACTATGGAACTAAAGGAGATAGTCCATTACA
TAGCATAAGGTGGCTAAGAGTGATCCTGGATGAAGGACATGCCATACGAAATCCAAATGCTCAGCAGACAAAAGCTGTACTTGACTTAGA
ATCAGAAAGAAGATGGGTTTTGACAGGTACTCCAATCCAGAATTCTTTAAAGGACTTGTGGTCTCTTCTTTCCTTTTTAAAACTTAAACC
ATTTATTGATAGAGAATGGTGGCATAGAACAATACAGCGTCCTGTCACAATGGGAGATGAAGGAGGACTTAGGCGTTTACAGTCCCTAAT
TAAAAATATTACACTTAGAAGAACAAAGACAAGCAAAATTAAAGGAAAACCTGTTTTGGAGTTACCAGAACGTAAAGTATTTATTCAGCA
CATTACACTTTCAGATGAAGAGAGAAAGATTTATCAGTCTGTGAAAAATGAAGGCAGAGCCACTATTGGAAGGTATTTTAATGAAGGGAC
TGTCCTGGCACATTATGCAGATGTCCTGGGTCTTTTGCTTAGACTGCGGCAAATTTGTTGCCATACTTACCTTCTTACAAATGCAGTGTC
TTCCAATGGCCCCTCAGGAAATGATACACCTGAAGAACTGAGAAAGAAGTTAATAAGGAAGATGAAGTTAATTCTGAGCTCAGGTTCAGA
TGAGGAATGTGCAATTTGCCTGGATTCTTTAACAGTTCCTGTGATAACACATTGTGCACATGTATTTTGTAAACCCTGTATTTGCCAAGT
CATTCAGAATGAGCAGCCACATGCTAAATGCCCTTTATGCAGAAATGATATACATGAAGATAATTTATTAGAATGTCCTCCAGAAGAATT
AGCACGTGACAGTGAGAAAAAGTCTGATATGGAATGGACATCCAGTTCAAAGATTAATGCGCTAATGCACGCATTGACTGACTTAAGAAA
GAAGAATCCCAACATAAAAAGTTTGGTTGTTTCTCAGTTTACAACATTCCTGTCTTTAATAGAAATACCACTTAAAGCCTCTGGATTTGT
GTTTACTCGTTTGGATGGTTCCATGGCCCAAAAGAAAAGAGTTGAATCAATTCAGTGTTTTCAAAACACTGAAGCAGGATCTCCAACTAT
AATGCTTCTGTCCTTAAAAGCAGGTGGAGTTGGTTTGAATCTGTCTGCAGCTTCTCGAGTGTTTTTAATGGATCCAGCCTGGAATCCTGC
TGCTGAAGATCAGTGCTTTGACAGATGCCATAGACTTGGTCAGAAGCAAGAAGTTATCATCACAAAATTCATTGTAAAGGACTCTGTTGA
AGAAAATATGCTGAAAATACAAAACAAAAAGAGAGAACTTGCAGCAGGAGCCTTTGGAACTAAAAAACCAAATGCTGACGAAATGAAACA
AGCCAAAATTAATGAAATCAGAACATTAATTGACTTATAATTTGTGGGATTTTAGTAAGACTACTATATGTGAGAGGCGTGATATCTGGA
TGGAAGTTGGGCTGGATGATCTCCAAAGTCGTTTCAACTCTTAAAGACATCTTAATCCTGAATGTAAACAATTGTTATGTGTTTAGAATC
AGAATTTGATTTTGAACTTGAGTAATTCATCCTTACAGCTATCTGTAGAATTAGTCATCTTTTTTCTTTTCTTTTTTTTTTACTTTTTTG
TTAATAAGCAAACTTATTTGCTGCAGAATTTGGGTTGACTCCTGAGCATATTTAAAACAAAGAAGCTAGAAATTTAGCAGTCAGATTAGG

>53489_53489_2_MIB1-HLTF_MIB1_chr18_19353689_ENST00000261537_HLTF_chr3_148802676_ENST00000494055_length(amino acids)=1021AA_BP=19
MSSGIMVLRTFTELALRAWDPVWKYLQTVQYGVHGNFPRLSYPTFFPRFEFQDVIPPDDFLTSDEEVDSVLFGSLRGHVVGLRYYTGVVN
NNEMVALQRDPNNPYDKNAIKVNNVNGNQVGHLKKELAGALAYIMDNKLAQIEGVVPFGANNAFTMPLHMTFWGKEENRKAVSDQLKKHG
FKLGPAPKTLGFNLESGWGSGRAGPSYSMPVHAAVQMTTEQLKTEFDKLFEDLKEDDKTHEMEPAEAIETPLLPHQKQALAWMVSRENSK
ELPPFWEQRNDLYYNTITNFSEKDRPENVHGGILADDMGLGKTLTAIAVILTNFHDGRPLPIERVKKNLLKKEYNVNDDSMKLGGNNTSE
KADGLSKDASRCSEQPSISDIKEKSKFRMSELSSSRPKRRKTAVQYIESSDSEEIETSELPQKMKGKLKNVQSETKGRAKAGSSKVIEDV
AFACALTSSVPTTKKKMLKKGACAVEGSKKTDVEERPRTTLIICPLSVLSNWIDQFGQHIKSDVHLNFYVYYGPDRIREPALLSKQDIVL
TTYNILTHDYGTKGDSPLHSIRWLRVILDEGHAIRNPNAQQTKAVLDLESERRWVLTGTPIQNSLKDLWSLLSFLKLKPFIDREWWHRTI
QRPVTMGDEGGLRRLQSLIKNITLRRTKTSKIKGKPVLELPERKVFIQHITLSDEERKIYQSVKNEGRATIGRYFNEGTVLAHYADVLGL
LLRLRQICCHTYLLTNAVSSNGPSGNDTPEELRKKLIRKMKLILSSGSDEECAICLDSLTVPVITHCAHVFCKPCICQVIQNEQPHAKCP
LCRNDIHEDNLLECPPEELARDSEKKSDMEWTSSSKINALMHALTDLRKKNPNIKSLVVSQFTTFLSLIEIPLKASGFVFTRLDGSMAQK
KRVESIQCFQNTEAGSPTIMLLSLKAGGVGLNLSAASRVFLMDPAWNPAAEDQCFDRCHRLGQKQEVIITKFIVKDSVEENMLKIQNKKR

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MIB1-HLTF

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	HLTF	chr18:19353689	chr3:148802676	ENST00000310053		0	25	925_1009	6.666666666666667	1010.0	SP1 and SP3
Tgene	HLTF	chr18:19353689	chr3:148802676	ENST00000392912		0	26	925_1009	6.666666666666667	1161.6666666666667	SP1 and SP3
Tgene	HLTF	chr18:19353689	chr3:148802676	ENST00000465259		0	25	925_1009	6.666666666666667	1009.0	SP1 and SP3
Tgene	HLTF	chr18:19353689	chr3:148802676	ENST00000494055		0	26	925_1009	6.666666666666667	1040.6666666666667	SP1 and SP3

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for MIB1-HLTF

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for MIB1-HLTF

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source