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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MICAL2-RHBDD1 (FusionGDB2 ID:53509)

Fusion Gene Summary for MICAL2-RHBDD1

check button Fusion gene summary
Fusion gene informationFusion gene name: MICAL2-RHBDD1
Fusion gene ID: 53509
HgeneTgene
Gene symbol

MICAL2

RHBDD1

Gene ID

9645

84236

Gene namemicrotubule associated monooxygenase, calponin and LIM domain containing 2rhomboid domain containing 1
SynonymsMICAL-2|MICAL2PV1|MICAL2PV2RHBDL4|RRP4
Cytomap

11p15.3

2q36.3

Type of geneprotein-codingprotein-coding
Description[F-actin]-monooxygenase MICAL2[F-actin]-methionine sulfoxide oxidase MICAL2flavoprotein oxidoreductase MICAL2microtubule associated monoxygenase, calponin and LIM domain containing 2molecule interacting with CasL protein 2protein-methionine sulfoxiderhomboid-related protein 4rhomboid domain-containing protein 1rhomboid-like protein 4
Modification date2020032020200313
UniProtAcc

O94851

.
Ensembl transtripts involved in fusion geneENST00000256194, ENST00000342902, 
ENST00000379612, ENST00000527546, 
ENST00000537344, ENST00000527195, 
ENST00000493526, ENST00000409053, 
ENST00000392062, ENST00000341329, 
Fusion gene scores* DoF score7 X 7 X 5=2458 X 7 X 4=224
# samples 78
** MAII scorelog2(7/245*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MICAL2 [Title/Abstract] AND RHBDD1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMICAL2(12257792)-RHBDD1(227860147), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMICAL2

GO:0007010

cytoskeleton organization

24440334

HgeneMICAL2

GO:0030042

actin filament depolymerization

24440334

HgeneMICAL2

GO:0055114

oxidation-reduction process

24440334


check buttonFusion gene breakpoints across MICAL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RHBDD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-0130-01AMICAL2chr11

12257792

+RHBDD1chr2

227860147

+


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Fusion Gene ORF analysis for MICAL2-RHBDD1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000256194ENST00000493526MICAL2chr11

12257792

+RHBDD1chr2

227860147

+
5CDS-3UTRENST00000342902ENST00000493526MICAL2chr11

12257792

+RHBDD1chr2

227860147

+
5CDS-3UTRENST00000379612ENST00000493526MICAL2chr11

12257792

+RHBDD1chr2

227860147

+
5CDS-3UTRENST00000527546ENST00000493526MICAL2chr11

12257792

+RHBDD1chr2

227860147

+
5CDS-3UTRENST00000537344ENST00000493526MICAL2chr11

12257792

+RHBDD1chr2

227860147

+
5CDS-intronENST00000256194ENST00000409053MICAL2chr11

12257792

+RHBDD1chr2

227860147

+
5CDS-intronENST00000342902ENST00000409053MICAL2chr11

12257792

+RHBDD1chr2

227860147

+
5CDS-intronENST00000379612ENST00000409053MICAL2chr11

12257792

+RHBDD1chr2

227860147

+
5CDS-intronENST00000527546ENST00000409053MICAL2chr11

12257792

+RHBDD1chr2

227860147

+
5CDS-intronENST00000537344ENST00000409053MICAL2chr11

12257792

+RHBDD1chr2

227860147

+
Frame-shiftENST00000256194ENST00000392062MICAL2chr11

12257792

+RHBDD1chr2

227860147

+
Frame-shiftENST00000342902ENST00000392062MICAL2chr11

12257792

+RHBDD1chr2

227860147

+
Frame-shiftENST00000379612ENST00000392062MICAL2chr11

12257792

+RHBDD1chr2

227860147

+
Frame-shiftENST00000527546ENST00000392062MICAL2chr11

12257792

+RHBDD1chr2

227860147

+
Frame-shiftENST00000537344ENST00000392062MICAL2chr11

12257792

+RHBDD1chr2

227860147

+
In-frameENST00000256194ENST00000341329MICAL2chr11

12257792

+RHBDD1chr2

227860147

+
In-frameENST00000342902ENST00000341329MICAL2chr11

12257792

+RHBDD1chr2

227860147

+
In-frameENST00000379612ENST00000341329MICAL2chr11

12257792

+RHBDD1chr2

227860147

+
In-frameENST00000527546ENST00000341329MICAL2chr11

12257792

+RHBDD1chr2

227860147

+
In-frameENST00000537344ENST00000341329MICAL2chr11

12257792

+RHBDD1chr2

227860147

+
intron-3CDSENST00000527195ENST00000341329MICAL2chr11

12257792

+RHBDD1chr2

227860147

+
intron-3CDSENST00000527195ENST00000392062MICAL2chr11

12257792

+RHBDD1chr2

227860147

+
intron-3UTRENST00000527195ENST00000493526MICAL2chr11

12257792

+RHBDD1chr2

227860147

+
intron-intronENST00000527195ENST00000409053MICAL2chr11

12257792

+RHBDD1chr2

227860147

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000537344MICAL2chr1112257792+ENST00000341329RHBDD1chr2227860147+623024453812501706
ENST00000256194MICAL2chr1112257792+ENST00000341329RHBDD1chr2227860147+613723522882408706
ENST00000527546MICAL2chr1112257792+ENST00000341329RHBDD1chr2227860147+600322181542274706
ENST00000342902MICAL2chr1112257792+ENST00000341329RHBDD1chr2227860147+596821831192239706
ENST00000379612MICAL2chr1112257792+ENST00000341329RHBDD1chr2227860147+5849206402120706

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000537344ENST00000341329MICAL2chr1112257792+RHBDD1chr2227860147+0.0002897430.99971026
ENST00000256194ENST00000341329MICAL2chr1112257792+RHBDD1chr2227860147+0.0002907140.9997093
ENST00000527546ENST00000341329MICAL2chr1112257792+RHBDD1chr2227860147+0.0002699950.99973005
ENST00000342902ENST00000341329MICAL2chr1112257792+RHBDD1chr2227860147+0.000269860.99973017
ENST00000379612ENST00000341329MICAL2chr1112257792+RHBDD1chr2227860147+0.000265450.9997346

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Fusion Genomic Features for MICAL2-RHBDD1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MICAL2-RHBDD1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:12257792/chr2:227860147)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MICAL2

O94851

.
FUNCTION: Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (PubMed:24440334). In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (By similarity). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA (PubMed:24440334). {ECO:0000250|UniProtKB:Q8TDZ2, ECO:0000269|PubMed:24440334}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMICAL2chr11:12257792chr2:227860147ENST00000256194+1628516_6196881155.0DomainCalponin-homology (CH)
HgeneMICAL2chr11:12257792chr2:227860147ENST00000342902+1526516_6196881099.6666666666667DomainCalponin-homology (CH)
HgeneMICAL2chr11:12257792chr2:227860147ENST00000379612+1419516_619688977.0DomainCalponin-homology (CH)
HgeneMICAL2chr11:12257792chr2:227860147ENST00000527546+1522516_619688935.0DomainCalponin-homology (CH)
HgeneMICAL2chr11:12257792chr2:227860147ENST00000537344+1623516_619688935.0DomainCalponin-homology (CH)
HgeneMICAL2chr11:12257792chr2:227860147ENST00000256194+1628660_6816881155.0MotifNuclear localization signal
HgeneMICAL2chr11:12257792chr2:227860147ENST00000342902+1526660_6816881099.6666666666667MotifNuclear localization signal
HgeneMICAL2chr11:12257792chr2:227860147ENST00000379612+1419660_681688977.0MotifNuclear localization signal
HgeneMICAL2chr11:12257792chr2:227860147ENST00000527546+1522660_681688935.0MotifNuclear localization signal
HgeneMICAL2chr11:12257792chr2:227860147ENST00000537344+1623660_681688935.0MotifNuclear localization signal
HgeneMICAL2chr11:12257792chr2:227860147ENST00000256194+1628116_1186881155.0Nucleotide bindingFAD
HgeneMICAL2chr11:12257792chr2:227860147ENST00000256194+1628123_1256881155.0Nucleotide bindingFAD
HgeneMICAL2chr11:12257792chr2:227860147ENST00000342902+1526116_1186881099.6666666666667Nucleotide bindingFAD
HgeneMICAL2chr11:12257792chr2:227860147ENST00000342902+1526123_1256881099.6666666666667Nucleotide bindingFAD
HgeneMICAL2chr11:12257792chr2:227860147ENST00000379612+1419116_118688977.0Nucleotide bindingFAD
HgeneMICAL2chr11:12257792chr2:227860147ENST00000379612+1419123_125688977.0Nucleotide bindingFAD
HgeneMICAL2chr11:12257792chr2:227860147ENST00000527546+1522116_118688935.0Nucleotide bindingFAD
HgeneMICAL2chr11:12257792chr2:227860147ENST00000527546+1522123_125688935.0Nucleotide bindingFAD
HgeneMICAL2chr11:12257792chr2:227860147ENST00000537344+1623116_118688935.0Nucleotide bindingFAD
HgeneMICAL2chr11:12257792chr2:227860147ENST00000537344+1623123_125688935.0Nucleotide bindingFAD
HgeneMICAL2chr11:12257792chr2:227860147ENST00000256194+16282_4946881155.0RegionMonooxygenase domain
HgeneMICAL2chr11:12257792chr2:227860147ENST00000342902+15262_4946881099.6666666666667RegionMonooxygenase domain
HgeneMICAL2chr11:12257792chr2:227860147ENST00000379612+14192_494688977.0RegionMonooxygenase domain
HgeneMICAL2chr11:12257792chr2:227860147ENST00000527546+15222_494688935.0RegionMonooxygenase domain
HgeneMICAL2chr11:12257792chr2:227860147ENST00000537344+16232_494688935.0RegionMonooxygenase domain
TgeneRHBDD1chr11:12257792chr2:227860147ENST0000034132957301_315285316.0RegionVCP/p97-interacting motif (VIM)
TgeneRHBDD1chr11:12257792chr2:227860147ENST0000039206279301_315285316.0RegionVCP/p97-interacting motif (VIM)

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMICAL2chr11:12257792chr2:227860147ENST00000256194+16281000_10626881155.0DomainLIM zinc-binding
HgeneMICAL2chr11:12257792chr2:227860147ENST00000342902+15261000_10626881099.6666666666667DomainLIM zinc-binding
HgeneMICAL2chr11:12257792chr2:227860147ENST00000379612+14191000_1062688977.0DomainLIM zinc-binding
HgeneMICAL2chr11:12257792chr2:227860147ENST00000527546+15221000_1062688935.0DomainLIM zinc-binding
HgeneMICAL2chr11:12257792chr2:227860147ENST00000537344+16231000_1062688935.0DomainLIM zinc-binding
TgeneRHBDD1chr11:12257792chr2:227860147ENST0000034132957269_284285316.0RegionUbiquitin-binding domain (UBD)
TgeneRHBDD1chr11:12257792chr2:227860147ENST0000039206279269_284285316.0RegionUbiquitin-binding domain (UBD)
TgeneRHBDD1chr11:12257792chr2:227860147ENST0000034132957128_138285316.0Topological domainCytoplasmic
TgeneRHBDD1chr11:12257792chr2:227860147ENST0000034132957158_180285316.0Topological domainExtracellular
TgeneRHBDD1chr11:12257792chr2:227860147ENST00000341329571_21285316.0Topological domainCytoplasmic
TgeneRHBDD1chr11:12257792chr2:227860147ENST0000034132957202_315285316.0Topological domainCytoplasmic
TgeneRHBDD1chr11:12257792chr2:227860147ENST000003413295743_106285316.0Topological domainExtracellular
TgeneRHBDD1chr11:12257792chr2:227860147ENST0000039206279128_138285316.0Topological domainCytoplasmic
TgeneRHBDD1chr11:12257792chr2:227860147ENST0000039206279158_180285316.0Topological domainExtracellular
TgeneRHBDD1chr11:12257792chr2:227860147ENST00000392062791_21285316.0Topological domainCytoplasmic
TgeneRHBDD1chr11:12257792chr2:227860147ENST0000039206279202_315285316.0Topological domainCytoplasmic
TgeneRHBDD1chr11:12257792chr2:227860147ENST000003920627943_106285316.0Topological domainExtracellular
TgeneRHBDD1chr11:12257792chr2:227860147ENST0000034132957107_127285316.0TransmembraneHelical
TgeneRHBDD1chr11:12257792chr2:227860147ENST0000034132957139_157285316.0TransmembraneHelical
TgeneRHBDD1chr11:12257792chr2:227860147ENST0000034132957181_201285316.0TransmembraneHelical
TgeneRHBDD1chr11:12257792chr2:227860147ENST000003413295722_42285316.0TransmembraneHelical
TgeneRHBDD1chr11:12257792chr2:227860147ENST0000039206279107_127285316.0TransmembraneHelical
TgeneRHBDD1chr11:12257792chr2:227860147ENST0000039206279139_157285316.0TransmembraneHelical
TgeneRHBDD1chr11:12257792chr2:227860147ENST0000039206279181_201285316.0TransmembraneHelical
TgeneRHBDD1chr11:12257792chr2:227860147ENST000003920627922_42285316.0TransmembraneHelical


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Fusion Gene Sequence for MICAL2-RHBDD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>53509_53509_1_MICAL2-RHBDD1_MICAL2_chr11_12257792_ENST00000256194_RHBDD1_chr2_227860147_ENST00000341329_length(transcript)=6137nt_BP=2352nt
CTCGGCTGGCTAAGCCTGCGCCGGGCCGCCTCGCTCGCTCCCAGCTCTGTCAGTGGCCCGCGGGGCCCGATCGCTGCGCCCGCGGCCAGG
GCCGAGGCAGGCCTGACCCGGGGCCGGGCAGCCCGCGCGACTTTCGGAACATGGCAACCCGTGTGTGTCTCATCCCAGAAAGAGAAGACT
TTAACCACTGTGATGCCTGAGAATCCAGTGAGTGTGACGTTTCTCCAGATACTTCATGCTGTTCACCTGTGTCCTCGCCGCACCACTGCC
GCACACGACTCCTGAACCATGGGGGAAAACGAGGATGAGAAGCAGGCCCAGGCGGGGCAGGTTTTTGAGAACTTTGTCCAGGCATCCACG
TGCAAAGGTACCCTCCAGGCCTTCAACATTCTCACACGACACCTGGACCTAGACCCTCTGGACCACAGAAACTTTTATTCCAAGCTCAAG
TCCAAGGTGACCACCTGGAAAGCCAAAGCCCTGTGGTACAAATTGGATAAGCGTGGTTCCCACAAAGAGTATAAGCGAGGGAAGTCGTGC
ACGAACACCAAGTGTCTCATAGTTGGGGGAGGACCCTGTGGCTTGCGCACTGCCATTGAACTTGCCTACCTGGGAGCCAAAGTGGTCGTG
GTGGAGAAGAGGGACTCCTTCTCCCGGAACAACGTGCTACACCTCTGGCCTTTCACCATCCATGACCTTCGTGGCCTGGGAGCCAAGAAG
TTCTATGGGAAGTTCTGTGCTGGCTCCATCGACCATATCAGTATTCGCCAACTACAGCTCATCCTATTCAAGGTGGCCCTGATGCTGGGA
GTTGAAATCCATGTGAATGTGGAGTTCGTGAAGGTTCTAGAGCCTCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGCGGGCAGAATTT
CTCCCTACAGACCATTCTCTGTCGGAGTTTGAGTTTGACGTCATCATTGGTGCCGATGGCCGCAGGAACACCCTGGAAGGGTTCAGAAGA
AAAGAATTCCGTGGGAAGCTGGCGATTGCCATCACCGCCAACTTCATAAACAGAAACAGCACAGCGGAAGCCAAGGTGGAAGAGATTAGT
GGTGTGGCTTTCATCTTCAATCAGAAATTTTTTCAGGACCTTAAAGAAGAAACAGGCATAGATCTTGAGAACATTGTTTACTACAAGGAC
TGCACCCACTATTTTGTAATGACAGCCAAGAAGCAGAGCCTGCTCGACAAAGGTGTCATCATTAACGACTACATCGACACAGAGATGCTG
CTGTGTGCGGAGAACGTGAACCAAGACAACCTGCTATCCTATGCCCGGGAAGCTGCAGACTTTGCCACCAACTACCAGCTGCCATCCTTA
GACTTTGCCATGAACCACTATGGGCAGCCTGATGTGGCCATGTTTGACTTTACCTGCATGTATGCCTCAGAGAACGCGGCCCTGGTGCGG
GAGCGGCAGGCGCACCAGCTGCTCGTGGCCCTTGTGGGTGACAGCTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCTGTGCCCGTGGC
TTCCTGGCAGCCTTTGACACGGCATGGATGGTGAAGAGCTGGAACCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAAGGGAAAGTCTC
TACCGGCTGTTACCTCAGACAACCCCGGAGAACATCAACAAGAACTTTGAGCAGTACACGTTGGACCCAGGGACACGGTACCCAAACCTC
AACTCACACTGTGTCAGGCCCCATCAGGTGAAGCATTTGTATATCACTAAGGAGCTGGAGCACTACCCTCTCGAGAGACTGGGCTCGGTG
AGGAGATCTGTCAACCTCTCCAGGAAGGAGTCAGATATCCGGCCCAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAGAGGGCTACCAG
CATGTCAACGTCACCGACCTGACCACATCCTGGCGCAGTGGGTTGGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTGAGCTCATCAAC
TTTGACTCTTTGAATGAAGATGATGCTGTGGAGAACAACCAGCTCGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCCCTCCAGTGACC
ACGGGCAAAGAGATGGCATCTGCCCAGGAGCCTGACAAGCTCAGCATGGTCATGTACCTCTCCAAGTTCTACGAGCTCTTCCGGGGCACC
CCACTGAGGCCCGTGGATTCTTGGCGCAAAAACTATGGAGAAAATGCTGACCTCAGCTTGGCCAAATCATCCATTTCTAATAACTATCTC
AACCTCACATTTCCAAGGAAGAGGACTCCACGGGTGGATGGTCAAACCGGAGAGAATGACATGAACAAACGGAGACGGAAGGGCTTCACC
AACCTGGACGAGGAAATACCAGAAATAGCCCACCACCCTACGGGTTTCATCTCTCACCAGAAGAAATGAGGAGACAGCGGCTTCACAGAT
TCGATAGCCAGTGAGGTGGCATCTTGGGAAGACATGGCCTATTCGTGTAATTATTGCCCATTTGGCTCATTCCCCAAGCCCCTAATTCAT
TTTAATTCATTTTAAACAAAAGCAGAGTACACCGGTATTGCTCCAGATCGCTCACATCACCTGGGACAGTCCCATGGCCCCTATGAGTCA
ACTCACAGCTTGCGGGGAGTGGGCCTTCTCCTGGCCTTGTTCTTGCTCATAAACAGGTCACTTCCTCCATGAAGAGACCAGTTTCCACGC
TCCCATCTCTCACTGCTGACTCAGCGATGCCTCTGCCTCGGTCTGCTTTTGAAGACTGTGACCTTCACCAGGAGGTTTTACTTACACCAG
TCGGGAAGATTAGTCCCTCATTCTGCCTGGAGTGCCCCGTGTTTGACTTGGCAGCGGGTGTGGAGCCATCCCCGCGTCCTCCTGGCGCAT
TGCCACTGTGGCTGTCCAGGAACAGGATGTGGCTGCCTTGGCCGAATGTTGTCCTACTCTCCCCAACCCCGGCGCCTCAGCTCCTCAGCT
CCTCGGGCCCCTGCGTCTGGCTGGTGTTTGCAGGGCTTTCGCTCTGCTCTGGTATTGCTCTGCCTTTATAGAAAGTCTTATTGAAGAAGT
GTAAGAAAGACCTAAGGTGGGGAAGACTCCTACACACACCATTAGTATCAGTGACACCAGCAATGTAGGTTCCCAGCCCCTTCCCAGTGG
CAGCTTGTGTGTCCAGGAGATAGGACATCATTTAACGCATCAGCAAAGTAGCAGCAGATGCCACATACAGAGTAGAGCGAAGGCATTTGG
TGGATCGGTCACTAGAGATCTATCTTGCAGAAAGTATGTTTTTCCTCATAAAAGTGCCTCTTAATTGGCCATTGTACCAGCCACTTGTCC
TAGCCAAATGTCCAAAACACGCCCTTGGGCCCCGCCACGTTACAATCCACAGATTGTCTGTCTGAGTCGTTTAAGGCATTTCCTGGTGCT
TGTGTTCCATGAATAAAAGGACAAAGTCAGAAGATCACTGATGTCTTACTGTCAACAGAGATATTTTAAAAGAGAGAAGCAGGAAAAGAT
CTTCCTTTTTTGATCTACAACTTATATAGTTTTCTGATTATGCACATAATAGATATGCCTTCCAGATGCATAAGGCAAACATCTGGAAAG
AAATATACCCAAATCTTAGCAGGGGTTATCTTTGGGAGTGGAGTACATGGGATTTTGCTTTCTTCATTTTTATAATTTTATATTACTGTC
TTGGAAGATGTGTTTATGTGTGTGTGTTACTTTTACAATCAGGAAAACATATTTAATAACATATAGTCAAGAAAACAGACTTAAAAATAA
ATACTATGTGTCCATTGAGAAAATTCACAATATAAACAGAAATACAAATAAATACATACACAATTTTAAAGTCACCTGTAGCCCTACCCT
TAGAGGTACCCAGGGTTAACATTTTGGTGGTATTGTCTTATCAATTTTTCCGTTGATACATTCAGCAAATTTGGAGCACATTGACCATGG
AGTTTTGTGTCCAAATCCAATCTGAATTTACCTGGAAGAGGCCTTGACACCTGCATGGAAATGAGCTAAGAAAACCACTGGAGCCTTGGG
AGCTCTTTGGCCTCCTGGCTGGCCCAGTAATATCTGAGCTCCTTTGGTTAATTTATAACTGATATAAAACTACATCTTCTTTATAATATA
AATTGTACCTGTGAGTCTAGAAGCTTTAAATGTGTTTAAATTAAAATATTCAAGCTAAATGTTACTGCTCTCTCCCAAATTCTGTAAGTT
TGACTCCCGTTACCCCAATTAGAAGTAACTTCTTTGTTTCATGCCACTTTTATAGCATTTGGTAATTCTGCTATAACACATCTTGCCCCT
ATTATTAACTGTGCACAGCTACACAAAGGTGTGCCTTCTACGTGGGAACATGGATTGTGAATGACTCTGTAATGAGGCCTGAGTCTTAGT
TATCTTTCCACTCACTCCCCGTCTCCCCTTTCCAACCCCAAAGGCTCACGATAGGGGCTCACTAAATGTCAGTGTTTCACCAAAGTATTT
TTTCCATTGTATTAAGAGTCCAGTCACTGTATATGGAAGTATTTTATTTTTTATTTTTTTATATCACTTGAGTCCACTAGTAGTACTTCC
TTGCTCTGTTTGACTTGTCAGATACAAAGACACGGGATTAGATTTTGGGTGGTAAAATTGTGATACGCATGGCTGTTGATGGAGTGGAAC
ATCTTAGTGATGTGAGAAAGGTCATTTTAGTTATAAATGTAAACCAATTACTTTAGCACAACAATAAAGATGTTCTGGAAATTATTATAA
TTATTTTAGTTAATGGACTTGCCTGTAACAAGTGCTTATGTTTGGAATGTCCATTTTATTTTATTTTCCTCTACAATAAGGAATCCCTAA
AGTTATGCCAACAAACTGGAATTGGATTGAGAAAGACAAAAGCAAGTGAGCAAGTGTATTAGACTAATTATCTCTAGTAGGGAATAAGCA
CTTAGAGCTAATTTTTTAATTTGGTTTATTTATTAGTAGCTCCCTGATTGTCTGTTAAGCCCCTGGTTCCCACAGTTTGGTGTGGTCAGT
CAACTTAAGCGACCTTTTAATGCAGAATCTTTACTTGGTTCTGAAGAGGAGGCAGTAGTTAAAATTGCTTCCTCTTAATGACTCTGAATG
TATTGCCTGTGATTCCAAAGTTGTACATAATTGTTCAGACCTCCTCCATCCTTTTAAATTGCCTGCTGCAGTAAATAACTAGTTTGAGTA
GAACTAGATCCTGTCTATCTATTTGGCACATGTTCTGCTGCCTGGGGAGTAAGCAAGCTAAAGGGATGAGAAAGACCACCTCCCCCTACC
CTGGAAATTGCACTGCAAGGCAGGGCGAGAATGGGGTAGCTGGCAGACCTGGCCTCCTTGTTCCCAGTCTTAGTTTTTCTTGAGAGATTC
AGTATTCAGTAAAGAATAGCATTCAATTAGTCAAAAAATATATATATAACTTCTTCCTTTCCCTTCCCATGAATCATTGCAGTCATTCCC
TAAGTTTCTTCTCTTTTTTTTTCATGGCTGCTAGTATTTTATTTTAGAATCACAGACTCTCAGCTTAGAGAGTCACAGTATCTCAATTAT
TTGCTCTGTTCAATACTTAACAATACCTCCTCACTCAATTCTACATAACTCCAGCTTAGTCTTCCAAAATTCACTTTCATGATGCCACTC
AGCATCTCAAATACCTTTCATTGGCTCTCTGCTGCCAAAGGATAAAGGTCAAAGTCATTAGCCTCAACAGTGGGCTTCAACCAGCCTTTG
GACCTCAGCCCCATTTATCCATCACAGAGGCTGGTAACTAGTCTCACTGCTCAGGCTGTGAGTGTTCCTGATCTTGTGACATTCTGTGCT
GTGCTTTTACATGGAACAGCTCTTTCCTCTCTCTTGGCCCATTCAGATCCTCCTCATCCAGCCCCCATCTGAATCCTGTAACAGACACAA
CCACATCTACACAGTTTCCACATACCACTTGGAATTGCTGGTTATGCTGCAATGAGAGAATGTCTTTGTCTTTAAATTGTAAGCTTCATG
AGGGCAGGGACCATCTGTTTCTCTGTCTCTCCTCACAGTGCCTTGAGCAGTACGTTGTCTGGAATGTCAGAACCAATAAATACTTGTGGA

>53509_53509_1_MICAL2-RHBDD1_MICAL2_chr11_12257792_ENST00000256194_RHBDD1_chr2_227860147_ENST00000341329_length(amino acids)=706AA_BP=688
MGENEDEKQAQAGQVFENFVQASTCKGTLQAFNILTRHLDLDPLDHRNFYSKLKSKVTTWKAKALWYKLDKRGSHKEYKRGKSCTNTKCL
IVGGGPCGLRTAIELAYLGAKVVVVEKRDSFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKVALMLGVEIHVN
VEFVKVLEPPEDQENQKIGWRAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAKVEEISGVAFIF
NQKFFQDLKEETGIDLENIVYYKDCTHYFVMTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDNLLSYAREAADFATNYQLPSLDFAMNH
YGQPDVAMFDFTCMYASENAALVRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWNQGTPPLELLAERESLYRLLPQ
TTPENINKNFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKELEHYPLERLGSVRRSVNLSRKESDIRPSKLLTWCQQQTEGYQHVNVTD
LTTSWRSGLALCAIIHRFRPELINFDSLNEDDAVENNQLAFDVAEREFGIPPVTTGKEMASAQEPDKLSMVMYLSKFYELFRGTPLRPVD

--------------------------------------------------------------
>53509_53509_2_MICAL2-RHBDD1_MICAL2_chr11_12257792_ENST00000342902_RHBDD1_chr2_227860147_ENST00000341329_length(transcript)=5968nt_BP=2183nt
AAGAGAAGACTTTAACCACTGTGATGCCTGAGAATCCAGTGAGTGTGACGTTTCTCCAGATACTTCATGCTGTTCACCTGTGTCCTCGCC
GCACCACTGCCGCACACGACTCCTGAACCATGGGGGAAAACGAGGATGAGAAGCAGGCCCAGGCGGGGCAGGTTTTTGAGAACTTTGTCC
AGGCATCCACGTGCAAAGGTACCCTCCAGGCCTTCAACATTCTCACACGACACCTGGACCTAGACCCTCTGGACCACAGAAACTTTTATT
CCAAGCTCAAGTCCAAGGTGACCACCTGGAAAGCCAAAGCCCTGTGGTACAAATTGGATAAGCGTGGTTCCCACAAAGAGTATAAGCGAG
GGAAGTCGTGCACGAACACCAAGTGTCTCATAGTTGGGGGAGGACCCTGTGGCTTGCGCACTGCCATTGAACTTGCCTACCTGGGAGCCA
AAGTGGTCGTGGTGGAGAAGAGGGACTCCTTCTCCCGGAACAACGTGCTACACCTCTGGCCTTTCACCATCCATGACCTTCGTGGCCTGG
GAGCCAAGAAGTTCTATGGGAAGTTCTGTGCTGGCTCCATCGACCATATCAGTATTCGCCAACTACAGCTCATCCTATTCAAGGTGGCCC
TGATGCTGGGAGTTGAAATCCATGTGAATGTGGAGTTCGTGAAGGTTCTAGAGCCTCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGC
GGGCAGAATTTCTCCCTACAGACCATTCTCTGTCGGAGTTTGAGTTTGACGTCATCATTGGTGCCGATGGCCGCAGGAACACCCTGGAAG
GGTTCAGAAGAAAAGAATTCCGTGGGAAGCTGGCGATTGCCATCACCGCCAACTTCATAAACAGAAACAGCACAGCGGAAGCCAAGGTGG
AAGAGATTAGTGGTGTGGCTTTCATCTTCAATCAGAAATTTTTTCAGGACCTTAAAGAAGAAACAGGCATAGATCTTGAGAACATTGTTT
ACTACAAGGACTGCACCCACTATTTTGTAATGACAGCCAAGAAGCAGAGCCTGCTCGACAAAGGTGTCATCATTAACGACTACATCGACA
CAGAGATGCTGCTGTGTGCGGAGAACGTGAACCAAGACAACCTGCTATCCTATGCCCGGGAAGCTGCAGACTTTGCCACCAACTACCAGC
TGCCATCCTTAGACTTTGCCATGAACCACTATGGGCAGCCTGATGTGGCCATGTTTGACTTTACCTGCATGTATGCCTCAGAGAACGCGG
CCCTGGTGCGGGAGCGGCAGGCGCACCAGCTGCTCGTGGCCCTTGTGGGTGACAGCTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCT
GTGCCCGTGGCTTCCTGGCAGCCTTTGACACGGCATGGATGGTGAAGAGCTGGAACCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAA
GGGAAAGTCTCTACCGGCTGTTACCTCAGACAACCCCGGAGAACATCAACAAGAACTTTGAGCAGTACACGTTGGACCCAGGGACACGGT
ACCCAAACCTCAACTCACACTGTGTCAGGCCCCATCAGGTGAAGCATTTGTATATCACTAAGGAGCTGGAGCACTACCCTCTCGAGAGAC
TGGGCTCGGTGAGGAGATCTGTCAACCTCTCCAGGAAGGAGTCAGATATCCGGCCCAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAG
AGGGCTACCAGCATGTCAACGTCACCGACCTGACCACATCCTGGCGCAGTGGGTTGGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTG
AGCTCATCAACTTTGACTCTTTGAATGAAGATGATGCTGTGGAGAACAACCAGCTCGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCC
CTCCAGTGACCACGGGCAAAGAGATGGCATCTGCCCAGGAGCCTGACAAGCTCAGCATGGTCATGTACCTCTCCAAGTTCTACGAGCTCT
TCCGGGGCACCCCACTGAGGCCCGTGGATTCTTGGCGCAAAAACTATGGAGAAAATGCTGACCTCAGCTTGGCCAAATCATCCATTTCTA
ATAACTATCTCAACCTCACATTTCCAAGGAAGAGGACTCCACGGGTGGATGGTCAAACCGGAGAGAATGACATGAACAAACGGAGACGGA
AGGGCTTCACCAACCTGGACGAGGAAATACCAGAAATAGCCCACCACCCTACGGGTTTCATCTCTCACCAGAAGAAATGAGGAGACAGCG
GCTTCACAGATTCGATAGCCAGTGAGGTGGCATCTTGGGAAGACATGGCCTATTCGTGTAATTATTGCCCATTTGGCTCATTCCCCAAGC
CCCTAATTCATTTTAATTCATTTTAAACAAAAGCAGAGTACACCGGTATTGCTCCAGATCGCTCACATCACCTGGGACAGTCCCATGGCC
CCTATGAGTCAACTCACAGCTTGCGGGGAGTGGGCCTTCTCCTGGCCTTGTTCTTGCTCATAAACAGGTCACTTCCTCCATGAAGAGACC
AGTTTCCACGCTCCCATCTCTCACTGCTGACTCAGCGATGCCTCTGCCTCGGTCTGCTTTTGAAGACTGTGACCTTCACCAGGAGGTTTT
ACTTACACCAGTCGGGAAGATTAGTCCCTCATTCTGCCTGGAGTGCCCCGTGTTTGACTTGGCAGCGGGTGTGGAGCCATCCCCGCGTCC
TCCTGGCGCATTGCCACTGTGGCTGTCCAGGAACAGGATGTGGCTGCCTTGGCCGAATGTTGTCCTACTCTCCCCAACCCCGGCGCCTCA
GCTCCTCAGCTCCTCGGGCCCCTGCGTCTGGCTGGTGTTTGCAGGGCTTTCGCTCTGCTCTGGTATTGCTCTGCCTTTATAGAAAGTCTT
ATTGAAGAAGTGTAAGAAAGACCTAAGGTGGGGAAGACTCCTACACACACCATTAGTATCAGTGACACCAGCAATGTAGGTTCCCAGCCC
CTTCCCAGTGGCAGCTTGTGTGTCCAGGAGATAGGACATCATTTAACGCATCAGCAAAGTAGCAGCAGATGCCACATACAGAGTAGAGCG
AAGGCATTTGGTGGATCGGTCACTAGAGATCTATCTTGCAGAAAGTATGTTTTTCCTCATAAAAGTGCCTCTTAATTGGCCATTGTACCA
GCCACTTGTCCTAGCCAAATGTCCAAAACACGCCCTTGGGCCCCGCCACGTTACAATCCACAGATTGTCTGTCTGAGTCGTTTAAGGCAT
TTCCTGGTGCTTGTGTTCCATGAATAAAAGGACAAAGTCAGAAGATCACTGATGTCTTACTGTCAACAGAGATATTTTAAAAGAGAGAAG
CAGGAAAAGATCTTCCTTTTTTGATCTACAACTTATATAGTTTTCTGATTATGCACATAATAGATATGCCTTCCAGATGCATAAGGCAAA
CATCTGGAAAGAAATATACCCAAATCTTAGCAGGGGTTATCTTTGGGAGTGGAGTACATGGGATTTTGCTTTCTTCATTTTTATAATTTT
ATATTACTGTCTTGGAAGATGTGTTTATGTGTGTGTGTTACTTTTACAATCAGGAAAACATATTTAATAACATATAGTCAAGAAAACAGA
CTTAAAAATAAATACTATGTGTCCATTGAGAAAATTCACAATATAAACAGAAATACAAATAAATACATACACAATTTTAAAGTCACCTGT
AGCCCTACCCTTAGAGGTACCCAGGGTTAACATTTTGGTGGTATTGTCTTATCAATTTTTCCGTTGATACATTCAGCAAATTTGGAGCAC
ATTGACCATGGAGTTTTGTGTCCAAATCCAATCTGAATTTACCTGGAAGAGGCCTTGACACCTGCATGGAAATGAGCTAAGAAAACCACT
GGAGCCTTGGGAGCTCTTTGGCCTCCTGGCTGGCCCAGTAATATCTGAGCTCCTTTGGTTAATTTATAACTGATATAAAACTACATCTTC
TTTATAATATAAATTGTACCTGTGAGTCTAGAAGCTTTAAATGTGTTTAAATTAAAATATTCAAGCTAAATGTTACTGCTCTCTCCCAAA
TTCTGTAAGTTTGACTCCCGTTACCCCAATTAGAAGTAACTTCTTTGTTTCATGCCACTTTTATAGCATTTGGTAATTCTGCTATAACAC
ATCTTGCCCCTATTATTAACTGTGCACAGCTACACAAAGGTGTGCCTTCTACGTGGGAACATGGATTGTGAATGACTCTGTAATGAGGCC
TGAGTCTTAGTTATCTTTCCACTCACTCCCCGTCTCCCCTTTCCAACCCCAAAGGCTCACGATAGGGGCTCACTAAATGTCAGTGTTTCA
CCAAAGTATTTTTTCCATTGTATTAAGAGTCCAGTCACTGTATATGGAAGTATTTTATTTTTTATTTTTTTATATCACTTGAGTCCACTA
GTAGTACTTCCTTGCTCTGTTTGACTTGTCAGATACAAAGACACGGGATTAGATTTTGGGTGGTAAAATTGTGATACGCATGGCTGTTGA
TGGAGTGGAACATCTTAGTGATGTGAGAAAGGTCATTTTAGTTATAAATGTAAACCAATTACTTTAGCACAACAATAAAGATGTTCTGGA
AATTATTATAATTATTTTAGTTAATGGACTTGCCTGTAACAAGTGCTTATGTTTGGAATGTCCATTTTATTTTATTTTCCTCTACAATAA
GGAATCCCTAAAGTTATGCCAACAAACTGGAATTGGATTGAGAAAGACAAAAGCAAGTGAGCAAGTGTATTAGACTAATTATCTCTAGTA
GGGAATAAGCACTTAGAGCTAATTTTTTAATTTGGTTTATTTATTAGTAGCTCCCTGATTGTCTGTTAAGCCCCTGGTTCCCACAGTTTG
GTGTGGTCAGTCAACTTAAGCGACCTTTTAATGCAGAATCTTTACTTGGTTCTGAAGAGGAGGCAGTAGTTAAAATTGCTTCCTCTTAAT
GACTCTGAATGTATTGCCTGTGATTCCAAAGTTGTACATAATTGTTCAGACCTCCTCCATCCTTTTAAATTGCCTGCTGCAGTAAATAAC
TAGTTTGAGTAGAACTAGATCCTGTCTATCTATTTGGCACATGTTCTGCTGCCTGGGGAGTAAGCAAGCTAAAGGGATGAGAAAGACCAC
CTCCCCCTACCCTGGAAATTGCACTGCAAGGCAGGGCGAGAATGGGGTAGCTGGCAGACCTGGCCTCCTTGTTCCCAGTCTTAGTTTTTC
TTGAGAGATTCAGTATTCAGTAAAGAATAGCATTCAATTAGTCAAAAAATATATATATAACTTCTTCCTTTCCCTTCCCATGAATCATTG
CAGTCATTCCCTAAGTTTCTTCTCTTTTTTTTTCATGGCTGCTAGTATTTTATTTTAGAATCACAGACTCTCAGCTTAGAGAGTCACAGT
ATCTCAATTATTTGCTCTGTTCAATACTTAACAATACCTCCTCACTCAATTCTACATAACTCCAGCTTAGTCTTCCAAAATTCACTTTCA
TGATGCCACTCAGCATCTCAAATACCTTTCATTGGCTCTCTGCTGCCAAAGGATAAAGGTCAAAGTCATTAGCCTCAACAGTGGGCTTCA
ACCAGCCTTTGGACCTCAGCCCCATTTATCCATCACAGAGGCTGGTAACTAGTCTCACTGCTCAGGCTGTGAGTGTTCCTGATCTTGTGA
CATTCTGTGCTGTGCTTTTACATGGAACAGCTCTTTCCTCTCTCTTGGCCCATTCAGATCCTCCTCATCCAGCCCCCATCTGAATCCTGT
AACAGACACAACCACATCTACACAGTTTCCACATACCACTTGGAATTGCTGGTTATGCTGCAATGAGAGAATGTCTTTGTCTTTAAATTG
TAAGCTTCATGAGGGCAGGGACCATCTGTTTCTCTGTCTCTCCTCACAGTGCCTTGAGCAGTACGTTGTCTGGAATGTCAGAACCAATAA

>53509_53509_2_MICAL2-RHBDD1_MICAL2_chr11_12257792_ENST00000342902_RHBDD1_chr2_227860147_ENST00000341329_length(amino acids)=706AA_BP=688
MGENEDEKQAQAGQVFENFVQASTCKGTLQAFNILTRHLDLDPLDHRNFYSKLKSKVTTWKAKALWYKLDKRGSHKEYKRGKSCTNTKCL
IVGGGPCGLRTAIELAYLGAKVVVVEKRDSFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKVALMLGVEIHVN
VEFVKVLEPPEDQENQKIGWRAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAKVEEISGVAFIF
NQKFFQDLKEETGIDLENIVYYKDCTHYFVMTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDNLLSYAREAADFATNYQLPSLDFAMNH
YGQPDVAMFDFTCMYASENAALVRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWNQGTPPLELLAERESLYRLLPQ
TTPENINKNFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKELEHYPLERLGSVRRSVNLSRKESDIRPSKLLTWCQQQTEGYQHVNVTD
LTTSWRSGLALCAIIHRFRPELINFDSLNEDDAVENNQLAFDVAEREFGIPPVTTGKEMASAQEPDKLSMVMYLSKFYELFRGTPLRPVD

--------------------------------------------------------------
>53509_53509_3_MICAL2-RHBDD1_MICAL2_chr11_12257792_ENST00000379612_RHBDD1_chr2_227860147_ENST00000341329_length(transcript)=5849nt_BP=2064nt
ATGGGGGAAAACGAGGATGAGAAGCAGGCCCAGGCGGGGCAGGTTTTTGAGAACTTTGTCCAGGCATCCACGTGCAAAGGTACCCTCCAG
GCCTTCAACATTCTCACACGACACCTGGACCTAGACCCTCTGGACCACAGAAACTTTTATTCCAAGCTCAAGTCCAAGGTGACCACCTGG
AAAGCCAAAGCCCTGTGGTACAAATTGGATAAGCGTGGTTCCCACAAAGAGTATAAGCGAGGGAAGTCGTGCACGAACACCAAGTGTCTC
ATAGTTGGGGGAGGACCCTGTGGCTTGCGCACTGCCATTGAACTTGCCTACCTGGGAGCCAAAGTGGTCGTGGTGGAGAAGAGGGACTCC
TTCTCCCGGAACAACGTGCTACACCTCTGGCCTTTCACCATCCATGACCTTCGTGGCCTGGGAGCCAAGAAGTTCTATGGGAAGTTCTGT
GCTGGCTCCATCGACCATATCAGTATTCGCCAACTACAGCTCATCCTATTCAAGGTGGCCCTGATGCTGGGAGTTGAAATCCATGTGAAT
GTGGAGTTCGTGAAGGTTCTAGAGCCTCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGCGGGCAGAATTTCTCCCTACAGACCATTCT
CTGTCGGAGTTTGAGTTTGACGTCATCATTGGTGCCGATGGCCGCAGGAACACCCTGGAAGGGTTCAGAAGAAAAGAATTCCGTGGGAAG
CTGGCGATTGCCATCACCGCCAACTTCATAAACAGAAACAGCACAGCGGAAGCCAAGGTGGAAGAGATTAGTGGTGTGGCTTTCATCTTC
AATCAGAAATTTTTTCAGGACCTTAAAGAAGAAACAGGCATAGATCTTGAGAACATTGTTTACTACAAGGACTGCACCCACTATTTTGTA
ATGACAGCCAAGAAGCAGAGCCTGCTCGACAAAGGTGTCATCATTAACGACTACATCGACACAGAGATGCTGCTGTGTGCGGAGAACGTG
AACCAAGACAACCTGCTATCCTATGCCCGGGAAGCTGCAGACTTTGCCACCAACTACCAGCTGCCATCCTTAGACTTTGCCATGAACCAC
TATGGGCAGCCTGATGTGGCCATGTTTGACTTTACCTGCATGTATGCCTCAGAGAACGCGGCCCTGGTGCGGGAGCGGCAGGCGCACCAG
CTGCTCGTGGCCCTTGTGGGTGACAGCTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCTGTGCCCGTGGCTTCCTGGCAGCCTTTGAC
ACGGCATGGATGGTGAAGAGCTGGAACCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAAGGGAAAGTCTCTACCGGCTGTTACCTCAG
ACAACCCCGGAGAACATCAACAAGAACTTTGAGCAGTACACGTTGGACCCAGGGACACGGTACCCAAACCTCAACTCACACTGTGTCAGG
CCCCATCAGGTGAAGCATTTGTATATCACTAAGGAGCTGGAGCACTACCCTCTCGAGAGACTGGGCTCGGTGAGGAGATCTGTCAACCTC
TCCAGGAAGGAGTCAGATATCCGGCCCAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAGAGGGCTACCAGCATGTCAACGTCACCGAC
CTGACCACATCCTGGCGCAGTGGGTTGGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTGAGCTCATCAACTTTGACTCTTTGAATGAA
GATGATGCTGTGGAGAACAACCAGCTCGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCCCTCCAGTGACCACGGGCAAAGAGATGGCA
TCTGCCCAGGAGCCTGACAAGCTCAGCATGGTCATGTACCTCTCCAAGTTCTACGAGCTCTTCCGGGGCACCCCACTGAGGCCCGTGGAT
TCTTGGCGCAAAAACTATGGAGAAAATGCTGACCTCAGCTTGGCCAAATCATCCATTTCTAATAACTATCTCAACCTCACATTTCCAAGG
AAGAGGACTCCACGGGTGGATGGTCAAACCGGAGAGAATGACATGAACAAACGGAGACGGAAGGGCTTCACCAACCTGGACGAGGAAATA
CCAGAAATAGCCCACCACCCTACGGGTTTCATCTCTCACCAGAAGAAATGAGGAGACAGCGGCTTCACAGATTCGATAGCCAGTGAGGTG
GCATCTTGGGAAGACATGGCCTATTCGTGTAATTATTGCCCATTTGGCTCATTCCCCAAGCCCCTAATTCATTTTAATTCATTTTAAACA
AAAGCAGAGTACACCGGTATTGCTCCAGATCGCTCACATCACCTGGGACAGTCCCATGGCCCCTATGAGTCAACTCACAGCTTGCGGGGA
GTGGGCCTTCTCCTGGCCTTGTTCTTGCTCATAAACAGGTCACTTCCTCCATGAAGAGACCAGTTTCCACGCTCCCATCTCTCACTGCTG
ACTCAGCGATGCCTCTGCCTCGGTCTGCTTTTGAAGACTGTGACCTTCACCAGGAGGTTTTACTTACACCAGTCGGGAAGATTAGTCCCT
CATTCTGCCTGGAGTGCCCCGTGTTTGACTTGGCAGCGGGTGTGGAGCCATCCCCGCGTCCTCCTGGCGCATTGCCACTGTGGCTGTCCA
GGAACAGGATGTGGCTGCCTTGGCCGAATGTTGTCCTACTCTCCCCAACCCCGGCGCCTCAGCTCCTCAGCTCCTCGGGCCCCTGCGTCT
GGCTGGTGTTTGCAGGGCTTTCGCTCTGCTCTGGTATTGCTCTGCCTTTATAGAAAGTCTTATTGAAGAAGTGTAAGAAAGACCTAAGGT
GGGGAAGACTCCTACACACACCATTAGTATCAGTGACACCAGCAATGTAGGTTCCCAGCCCCTTCCCAGTGGCAGCTTGTGTGTCCAGGA
GATAGGACATCATTTAACGCATCAGCAAAGTAGCAGCAGATGCCACATACAGAGTAGAGCGAAGGCATTTGGTGGATCGGTCACTAGAGA
TCTATCTTGCAGAAAGTATGTTTTTCCTCATAAAAGTGCCTCTTAATTGGCCATTGTACCAGCCACTTGTCCTAGCCAAATGTCCAAAAC
ACGCCCTTGGGCCCCGCCACGTTACAATCCACAGATTGTCTGTCTGAGTCGTTTAAGGCATTTCCTGGTGCTTGTGTTCCATGAATAAAA
GGACAAAGTCAGAAGATCACTGATGTCTTACTGTCAACAGAGATATTTTAAAAGAGAGAAGCAGGAAAAGATCTTCCTTTTTTGATCTAC
AACTTATATAGTTTTCTGATTATGCACATAATAGATATGCCTTCCAGATGCATAAGGCAAACATCTGGAAAGAAATATACCCAAATCTTA
GCAGGGGTTATCTTTGGGAGTGGAGTACATGGGATTTTGCTTTCTTCATTTTTATAATTTTATATTACTGTCTTGGAAGATGTGTTTATG
TGTGTGTGTTACTTTTACAATCAGGAAAACATATTTAATAACATATAGTCAAGAAAACAGACTTAAAAATAAATACTATGTGTCCATTGA
GAAAATTCACAATATAAACAGAAATACAAATAAATACATACACAATTTTAAAGTCACCTGTAGCCCTACCCTTAGAGGTACCCAGGGTTA
ACATTTTGGTGGTATTGTCTTATCAATTTTTCCGTTGATACATTCAGCAAATTTGGAGCACATTGACCATGGAGTTTTGTGTCCAAATCC
AATCTGAATTTACCTGGAAGAGGCCTTGACACCTGCATGGAAATGAGCTAAGAAAACCACTGGAGCCTTGGGAGCTCTTTGGCCTCCTGG
CTGGCCCAGTAATATCTGAGCTCCTTTGGTTAATTTATAACTGATATAAAACTACATCTTCTTTATAATATAAATTGTACCTGTGAGTCT
AGAAGCTTTAAATGTGTTTAAATTAAAATATTCAAGCTAAATGTTACTGCTCTCTCCCAAATTCTGTAAGTTTGACTCCCGTTACCCCAA
TTAGAAGTAACTTCTTTGTTTCATGCCACTTTTATAGCATTTGGTAATTCTGCTATAACACATCTTGCCCCTATTATTAACTGTGCACAG
CTACACAAAGGTGTGCCTTCTACGTGGGAACATGGATTGTGAATGACTCTGTAATGAGGCCTGAGTCTTAGTTATCTTTCCACTCACTCC
CCGTCTCCCCTTTCCAACCCCAAAGGCTCACGATAGGGGCTCACTAAATGTCAGTGTTTCACCAAAGTATTTTTTCCATTGTATTAAGAG
TCCAGTCACTGTATATGGAAGTATTTTATTTTTTATTTTTTTATATCACTTGAGTCCACTAGTAGTACTTCCTTGCTCTGTTTGACTTGT
CAGATACAAAGACACGGGATTAGATTTTGGGTGGTAAAATTGTGATACGCATGGCTGTTGATGGAGTGGAACATCTTAGTGATGTGAGAA
AGGTCATTTTAGTTATAAATGTAAACCAATTACTTTAGCACAACAATAAAGATGTTCTGGAAATTATTATAATTATTTTAGTTAATGGAC
TTGCCTGTAACAAGTGCTTATGTTTGGAATGTCCATTTTATTTTATTTTCCTCTACAATAAGGAATCCCTAAAGTTATGCCAACAAACTG
GAATTGGATTGAGAAAGACAAAAGCAAGTGAGCAAGTGTATTAGACTAATTATCTCTAGTAGGGAATAAGCACTTAGAGCTAATTTTTTA
ATTTGGTTTATTTATTAGTAGCTCCCTGATTGTCTGTTAAGCCCCTGGTTCCCACAGTTTGGTGTGGTCAGTCAACTTAAGCGACCTTTT
AATGCAGAATCTTTACTTGGTTCTGAAGAGGAGGCAGTAGTTAAAATTGCTTCCTCTTAATGACTCTGAATGTATTGCCTGTGATTCCAA
AGTTGTACATAATTGTTCAGACCTCCTCCATCCTTTTAAATTGCCTGCTGCAGTAAATAACTAGTTTGAGTAGAACTAGATCCTGTCTAT
CTATTTGGCACATGTTCTGCTGCCTGGGGAGTAAGCAAGCTAAAGGGATGAGAAAGACCACCTCCCCCTACCCTGGAAATTGCACTGCAA
GGCAGGGCGAGAATGGGGTAGCTGGCAGACCTGGCCTCCTTGTTCCCAGTCTTAGTTTTTCTTGAGAGATTCAGTATTCAGTAAAGAATA
GCATTCAATTAGTCAAAAAATATATATATAACTTCTTCCTTTCCCTTCCCATGAATCATTGCAGTCATTCCCTAAGTTTCTTCTCTTTTT
TTTTCATGGCTGCTAGTATTTTATTTTAGAATCACAGACTCTCAGCTTAGAGAGTCACAGTATCTCAATTATTTGCTCTGTTCAATACTT
AACAATACCTCCTCACTCAATTCTACATAACTCCAGCTTAGTCTTCCAAAATTCACTTTCATGATGCCACTCAGCATCTCAAATACCTTT
CATTGGCTCTCTGCTGCCAAAGGATAAAGGTCAAAGTCATTAGCCTCAACAGTGGGCTTCAACCAGCCTTTGGACCTCAGCCCCATTTAT
CCATCACAGAGGCTGGTAACTAGTCTCACTGCTCAGGCTGTGAGTGTTCCTGATCTTGTGACATTCTGTGCTGTGCTTTTACATGGAACA
GCTCTTTCCTCTCTCTTGGCCCATTCAGATCCTCCTCATCCAGCCCCCATCTGAATCCTGTAACAGACACAACCACATCTACACAGTTTC
CACATACCACTTGGAATTGCTGGTTATGCTGCAATGAGAGAATGTCTTTGTCTTTAAATTGTAAGCTTCATGAGGGCAGGGACCATCTGT

>53509_53509_3_MICAL2-RHBDD1_MICAL2_chr11_12257792_ENST00000379612_RHBDD1_chr2_227860147_ENST00000341329_length(amino acids)=706AA_BP=688
MGENEDEKQAQAGQVFENFVQASTCKGTLQAFNILTRHLDLDPLDHRNFYSKLKSKVTTWKAKALWYKLDKRGSHKEYKRGKSCTNTKCL
IVGGGPCGLRTAIELAYLGAKVVVVEKRDSFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKVALMLGVEIHVN
VEFVKVLEPPEDQENQKIGWRAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAKVEEISGVAFIF
NQKFFQDLKEETGIDLENIVYYKDCTHYFVMTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDNLLSYAREAADFATNYQLPSLDFAMNH
YGQPDVAMFDFTCMYASENAALVRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWNQGTPPLELLAERESLYRLLPQ
TTPENINKNFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKELEHYPLERLGSVRRSVNLSRKESDIRPSKLLTWCQQQTEGYQHVNVTD
LTTSWRSGLALCAIIHRFRPELINFDSLNEDDAVENNQLAFDVAEREFGIPPVTTGKEMASAQEPDKLSMVMYLSKFYELFRGTPLRPVD

--------------------------------------------------------------
>53509_53509_4_MICAL2-RHBDD1_MICAL2_chr11_12257792_ENST00000527546_RHBDD1_chr2_227860147_ENST00000341329_length(transcript)=6003nt_BP=2218nt
AGGAACATGGCAACCCGTGTGTGTCTCATCCCAGAAAGAGAAGACTTTAACCACTGTGATGCCTGAGAATCCAGTGAGTGTGACGTTTCT
CCAGATACTTCATGCTGTTCACCTGTGTCCTCGCCGCACCACTGCCGCACACGACTCCTGAACCATGGGGGAAAACGAGGATGAGAAGCA
GGCCCAGGCGGGGCAGGTTTTTGAGAACTTTGTCCAGGCATCCACGTGCAAAGGTACCCTCCAGGCCTTCAACATTCTCACACGACACCT
GGACCTAGACCCTCTGGACCACAGAAACTTTTATTCCAAGCTCAAGTCCAAGGTGACCACCTGGAAAGCCAAAGCCCTGTGGTACAAATT
GGATAAGCGTGGTTCCCACAAAGAGTATAAGCGAGGGAAGTCGTGCACGAACACCAAGTGTCTCATAGTTGGGGGAGGACCCTGTGGCTT
GCGCACTGCCATTGAACTTGCCTACCTGGGAGCCAAAGTGGTCGTGGTGGAGAAGAGGGACTCCTTCTCCCGGAACAACGTGCTACACCT
CTGGCCTTTCACCATCCATGACCTTCGTGGCCTGGGAGCCAAGAAGTTCTATGGGAAGTTCTGTGCTGGCTCCATCGACCATATCAGTAT
TCGCCAACTACAGCTCATCCTATTCAAGGTGGCCCTGATGCTGGGAGTTGAAATCCATGTGAATGTGGAGTTCGTGAAGGTTCTAGAGCC
TCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGCGGGCAGAATTTCTCCCTACAGACCATTCTCTGTCGGAGTTTGAGTTTGACGTCAT
CATTGGTGCCGATGGCCGCAGGAACACCCTGGAAGGGTTCAGAAGAAAAGAATTCCGTGGGAAGCTGGCGATTGCCATCACCGCCAACTT
CATAAACAGAAACAGCACAGCGGAAGCCAAGGTGGAAGAGATTAGTGGTGTGGCTTTCATCTTCAATCAGAAATTTTTTCAGGACCTTAA
AGAAGAAACAGGCATAGATCTTGAGAACATTGTTTACTACAAGGACTGCACCCACTATTTTGTAATGACAGCCAAGAAGCAGAGCCTGCT
CGACAAAGGTGTCATCATTAACGACTACATCGACACAGAGATGCTGCTGTGTGCGGAGAACGTGAACCAAGACAACCTGCTATCCTATGC
CCGGGAAGCTGCAGACTTTGCCACCAACTACCAGCTGCCATCCTTAGACTTTGCCATGAACCACTATGGGCAGCCTGATGTGGCCATGTT
TGACTTTACCTGCATGTATGCCTCAGAGAACGCGGCCCTGGTGCGGGAGCGGCAGGCGCACCAGCTGCTCGTGGCCCTTGTGGGTGACAG
CTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCTGTGCCCGTGGCTTCCTGGCAGCCTTTGACACGGCATGGATGGTGAAGAGCTGGAA
CCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAAGGGAAAGTCTCTACCGGCTGTTACCTCAGACAACCCCGGAGAACATCAACAAGAA
CTTTGAGCAGTACACGTTGGACCCAGGGACACGGTACCCAAACCTCAACTCACACTGTGTCAGGCCCCATCAGGTGAAGCATTTGTATAT
CACTAAGGAGCTGGAGCACTACCCTCTCGAGAGACTGGGCTCGGTGAGGAGATCTGTCAACCTCTCCAGGAAGGAGTCAGATATCCGGCC
CAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAGAGGGCTACCAGCATGTCAACGTCACCGACCTGACCACATCCTGGCGCAGTGGGTT
GGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTGAGCTCATCAACTTTGACTCTTTGAATGAAGATGATGCTGTGGAGAACAACCAGCT
CGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCCCTCCAGTGACCACGGGCAAAGAGATGGCATCTGCCCAGGAGCCTGACAAGCTCAG
CATGGTCATGTACCTCTCCAAGTTCTACGAGCTCTTCCGGGGCACCCCACTGAGGCCCGTGGATTCTTGGCGCAAAAACTATGGAGAAAA
TGCTGACCTCAGCTTGGCCAAATCATCCATTTCTAATAACTATCTCAACCTCACATTTCCAAGGAAGAGGACTCCACGGGTGGATGGTCA
AACCGGAGAGAATGACATGAACAAACGGAGACGGAAGGGCTTCACCAACCTGGACGAGGAAATACCAGAAATAGCCCACCACCCTACGGG
TTTCATCTCTCACCAGAAGAAATGAGGAGACAGCGGCTTCACAGATTCGATAGCCAGTGAGGTGGCATCTTGGGAAGACATGGCCTATTC
GTGTAATTATTGCCCATTTGGCTCATTCCCCAAGCCCCTAATTCATTTTAATTCATTTTAAACAAAAGCAGAGTACACCGGTATTGCTCC
AGATCGCTCACATCACCTGGGACAGTCCCATGGCCCCTATGAGTCAACTCACAGCTTGCGGGGAGTGGGCCTTCTCCTGGCCTTGTTCTT
GCTCATAAACAGGTCACTTCCTCCATGAAGAGACCAGTTTCCACGCTCCCATCTCTCACTGCTGACTCAGCGATGCCTCTGCCTCGGTCT
GCTTTTGAAGACTGTGACCTTCACCAGGAGGTTTTACTTACACCAGTCGGGAAGATTAGTCCCTCATTCTGCCTGGAGTGCCCCGTGTTT
GACTTGGCAGCGGGTGTGGAGCCATCCCCGCGTCCTCCTGGCGCATTGCCACTGTGGCTGTCCAGGAACAGGATGTGGCTGCCTTGGCCG
AATGTTGTCCTACTCTCCCCAACCCCGGCGCCTCAGCTCCTCAGCTCCTCGGGCCCCTGCGTCTGGCTGGTGTTTGCAGGGCTTTCGCTC
TGCTCTGGTATTGCTCTGCCTTTATAGAAAGTCTTATTGAAGAAGTGTAAGAAAGACCTAAGGTGGGGAAGACTCCTACACACACCATTA
GTATCAGTGACACCAGCAATGTAGGTTCCCAGCCCCTTCCCAGTGGCAGCTTGTGTGTCCAGGAGATAGGACATCATTTAACGCATCAGC
AAAGTAGCAGCAGATGCCACATACAGAGTAGAGCGAAGGCATTTGGTGGATCGGTCACTAGAGATCTATCTTGCAGAAAGTATGTTTTTC
CTCATAAAAGTGCCTCTTAATTGGCCATTGTACCAGCCACTTGTCCTAGCCAAATGTCCAAAACACGCCCTTGGGCCCCGCCACGTTACA
ATCCACAGATTGTCTGTCTGAGTCGTTTAAGGCATTTCCTGGTGCTTGTGTTCCATGAATAAAAGGACAAAGTCAGAAGATCACTGATGT
CTTACTGTCAACAGAGATATTTTAAAAGAGAGAAGCAGGAAAAGATCTTCCTTTTTTGATCTACAACTTATATAGTTTTCTGATTATGCA
CATAATAGATATGCCTTCCAGATGCATAAGGCAAACATCTGGAAAGAAATATACCCAAATCTTAGCAGGGGTTATCTTTGGGAGTGGAGT
ACATGGGATTTTGCTTTCTTCATTTTTATAATTTTATATTACTGTCTTGGAAGATGTGTTTATGTGTGTGTGTTACTTTTACAATCAGGA
AAACATATTTAATAACATATAGTCAAGAAAACAGACTTAAAAATAAATACTATGTGTCCATTGAGAAAATTCACAATATAAACAGAAATA
CAAATAAATACATACACAATTTTAAAGTCACCTGTAGCCCTACCCTTAGAGGTACCCAGGGTTAACATTTTGGTGGTATTGTCTTATCAA
TTTTTCCGTTGATACATTCAGCAAATTTGGAGCACATTGACCATGGAGTTTTGTGTCCAAATCCAATCTGAATTTACCTGGAAGAGGCCT
TGACACCTGCATGGAAATGAGCTAAGAAAACCACTGGAGCCTTGGGAGCTCTTTGGCCTCCTGGCTGGCCCAGTAATATCTGAGCTCCTT
TGGTTAATTTATAACTGATATAAAACTACATCTTCTTTATAATATAAATTGTACCTGTGAGTCTAGAAGCTTTAAATGTGTTTAAATTAA
AATATTCAAGCTAAATGTTACTGCTCTCTCCCAAATTCTGTAAGTTTGACTCCCGTTACCCCAATTAGAAGTAACTTCTTTGTTTCATGC
CACTTTTATAGCATTTGGTAATTCTGCTATAACACATCTTGCCCCTATTATTAACTGTGCACAGCTACACAAAGGTGTGCCTTCTACGTG
GGAACATGGATTGTGAATGACTCTGTAATGAGGCCTGAGTCTTAGTTATCTTTCCACTCACTCCCCGTCTCCCCTTTCCAACCCCAAAGG
CTCACGATAGGGGCTCACTAAATGTCAGTGTTTCACCAAAGTATTTTTTCCATTGTATTAAGAGTCCAGTCACTGTATATGGAAGTATTT
TATTTTTTATTTTTTTATATCACTTGAGTCCACTAGTAGTACTTCCTTGCTCTGTTTGACTTGTCAGATACAAAGACACGGGATTAGATT
TTGGGTGGTAAAATTGTGATACGCATGGCTGTTGATGGAGTGGAACATCTTAGTGATGTGAGAAAGGTCATTTTAGTTATAAATGTAAAC
CAATTACTTTAGCACAACAATAAAGATGTTCTGGAAATTATTATAATTATTTTAGTTAATGGACTTGCCTGTAACAAGTGCTTATGTTTG
GAATGTCCATTTTATTTTATTTTCCTCTACAATAAGGAATCCCTAAAGTTATGCCAACAAACTGGAATTGGATTGAGAAAGACAAAAGCA
AGTGAGCAAGTGTATTAGACTAATTATCTCTAGTAGGGAATAAGCACTTAGAGCTAATTTTTTAATTTGGTTTATTTATTAGTAGCTCCC
TGATTGTCTGTTAAGCCCCTGGTTCCCACAGTTTGGTGTGGTCAGTCAACTTAAGCGACCTTTTAATGCAGAATCTTTACTTGGTTCTGA
AGAGGAGGCAGTAGTTAAAATTGCTTCCTCTTAATGACTCTGAATGTATTGCCTGTGATTCCAAAGTTGTACATAATTGTTCAGACCTCC
TCCATCCTTTTAAATTGCCTGCTGCAGTAAATAACTAGTTTGAGTAGAACTAGATCCTGTCTATCTATTTGGCACATGTTCTGCTGCCTG
GGGAGTAAGCAAGCTAAAGGGATGAGAAAGACCACCTCCCCCTACCCTGGAAATTGCACTGCAAGGCAGGGCGAGAATGGGGTAGCTGGC
AGACCTGGCCTCCTTGTTCCCAGTCTTAGTTTTTCTTGAGAGATTCAGTATTCAGTAAAGAATAGCATTCAATTAGTCAAAAAATATATA
TATAACTTCTTCCTTTCCCTTCCCATGAATCATTGCAGTCATTCCCTAAGTTTCTTCTCTTTTTTTTTCATGGCTGCTAGTATTTTATTT
TAGAATCACAGACTCTCAGCTTAGAGAGTCACAGTATCTCAATTATTTGCTCTGTTCAATACTTAACAATACCTCCTCACTCAATTCTAC
ATAACTCCAGCTTAGTCTTCCAAAATTCACTTTCATGATGCCACTCAGCATCTCAAATACCTTTCATTGGCTCTCTGCTGCCAAAGGATA
AAGGTCAAAGTCATTAGCCTCAACAGTGGGCTTCAACCAGCCTTTGGACCTCAGCCCCATTTATCCATCACAGAGGCTGGTAACTAGTCT
CACTGCTCAGGCTGTGAGTGTTCCTGATCTTGTGACATTCTGTGCTGTGCTTTTACATGGAACAGCTCTTTCCTCTCTCTTGGCCCATTC
AGATCCTCCTCATCCAGCCCCCATCTGAATCCTGTAACAGACACAACCACATCTACACAGTTTCCACATACCACTTGGAATTGCTGGTTA
TGCTGCAATGAGAGAATGTCTTTGTCTTTAAATTGTAAGCTTCATGAGGGCAGGGACCATCTGTTTCTCTGTCTCTCCTCACAGTGCCTT

>53509_53509_4_MICAL2-RHBDD1_MICAL2_chr11_12257792_ENST00000527546_RHBDD1_chr2_227860147_ENST00000341329_length(amino acids)=706AA_BP=688
MGENEDEKQAQAGQVFENFVQASTCKGTLQAFNILTRHLDLDPLDHRNFYSKLKSKVTTWKAKALWYKLDKRGSHKEYKRGKSCTNTKCL
IVGGGPCGLRTAIELAYLGAKVVVVEKRDSFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKVALMLGVEIHVN
VEFVKVLEPPEDQENQKIGWRAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAKVEEISGVAFIF
NQKFFQDLKEETGIDLENIVYYKDCTHYFVMTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDNLLSYAREAADFATNYQLPSLDFAMNH
YGQPDVAMFDFTCMYASENAALVRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWNQGTPPLELLAERESLYRLLPQ
TTPENINKNFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKELEHYPLERLGSVRRSVNLSRKESDIRPSKLLTWCQQQTEGYQHVNVTD
LTTSWRSGLALCAIIHRFRPELINFDSLNEDDAVENNQLAFDVAEREFGIPPVTTGKEMASAQEPDKLSMVMYLSKFYELFRGTPLRPVD

--------------------------------------------------------------
>53509_53509_5_MICAL2-RHBDD1_MICAL2_chr11_12257792_ENST00000537344_RHBDD1_chr2_227860147_ENST00000341329_length(transcript)=6230nt_BP=2445nt
ATGCACTGAGGTACCAAGACTAATGAAGGTCCGGCCCTCCCCAGTGTAGGAGGCAGGTAAATGATCACACTGTGACAAATGCTCAAACGG
GGATGTGCTTGCAAAGGCTAGAGACAGCACGGGAGGAAGGAGCAGTCCATTCTGCTGAGAGTGTGAGTACCGAGAAAGCATGGCACTGGG
CTTGAAGGATGAGGAGTTCGCCAGACACAGAGGATGAGGAGAGCAGCACGAACATGGCAACCCGTGTGTGTCTCATCCCAGAAAGAGAAG
ACTTTAACCACTGTGATGCCTGAGAATCCAGTGAGTGTGACGTTTCTCCAGATACTTCATGCTGTTCACCTGTGTCCTCGCCGCACCACT
GCCGCACACGACTCCTGAACCATGGGGGAAAACGAGGATGAGAAGCAGGCCCAGGCGGGGCAGGTTTTTGAGAACTTTGTCCAGGCATCC
ACGTGCAAAGGTACCCTCCAGGCCTTCAACATTCTCACACGACACCTGGACCTAGACCCTCTGGACCACAGAAACTTTTATTCCAAGCTC
AAGTCCAAGGTGACCACCTGGAAAGCCAAAGCCCTGTGGTACAAATTGGATAAGCGTGGTTCCCACAAAGAGTATAAGCGAGGGAAGTCG
TGCACGAACACCAAGTGTCTCATAGTTGGGGGAGGACCCTGTGGCTTGCGCACTGCCATTGAACTTGCCTACCTGGGAGCCAAAGTGGTC
GTGGTGGAGAAGAGGGACTCCTTCTCCCGGAACAACGTGCTACACCTCTGGCCTTTCACCATCCATGACCTTCGTGGCCTGGGAGCCAAG
AAGTTCTATGGGAAGTTCTGTGCTGGCTCCATCGACCATATCAGTATTCGCCAACTACAGCTCATCCTATTCAAGGTGGCCCTGATGCTG
GGAGTTGAAATCCATGTGAATGTGGAGTTCGTGAAGGTTCTAGAGCCTCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGCGGGCAGAA
TTTCTCCCTACAGACCATTCTCTGTCGGAGTTTGAGTTTGACGTCATCATTGGTGCCGATGGCCGCAGGAACACCCTGGAAGGGTTCAGA
AGAAAAGAATTCCGTGGGAAGCTGGCGATTGCCATCACCGCCAACTTCATAAACAGAAACAGCACAGCGGAAGCCAAGGTGGAAGAGATT
AGTGGTGTGGCTTTCATCTTCAATCAGAAATTTTTTCAGGACCTTAAAGAAGAAACAGGCATAGATCTTGAGAACATTGTTTACTACAAG
GACTGCACCCACTATTTTGTAATGACAGCCAAGAAGCAGAGCCTGCTCGACAAAGGTGTCATCATTAACGACTACATCGACACAGAGATG
CTGCTGTGTGCGGAGAACGTGAACCAAGACAACCTGCTATCCTATGCCCGGGAAGCTGCAGACTTTGCCACCAACTACCAGCTGCCATCC
TTAGACTTTGCCATGAACCACTATGGGCAGCCTGATGTGGCCATGTTTGACTTTACCTGCATGTATGCCTCAGAGAACGCGGCCCTGGTG
CGGGAGCGGCAGGCGCACCAGCTGCTCGTGGCCCTTGTGGGTGACAGCTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCTGTGCCCGT
GGCTTCCTGGCAGCCTTTGACACGGCATGGATGGTGAAGAGCTGGAACCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAAGGGAAAGT
CTCTACCGGCTGTTACCTCAGACAACCCCGGAGAACATCAACAAGAACTTTGAGCAGTACACGTTGGACCCAGGGACACGGTACCCAAAC
CTCAACTCACACTGTGTCAGGCCCCATCAGGTGAAGCATTTGTATATCACTAAGGAGCTGGAGCACTACCCTCTCGAGAGACTGGGCTCG
GTGAGGAGATCTGTCAACCTCTCCAGGAAGGAGTCAGATATCCGGCCCAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAGAGGGCTAC
CAGCATGTCAACGTCACCGACCTGACCACATCCTGGCGCAGTGGGTTGGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTGAGCTCATC
AACTTTGACTCTTTGAATGAAGATGATGCTGTGGAGAACAACCAGCTCGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCCCTCCAGTG
ACCACGGGCAAAGAGATGGCATCTGCCCAGGAGCCTGACAAGCTCAGCATGGTCATGTACCTCTCCAAGTTCTACGAGCTCTTCCGGGGC
ACCCCACTGAGGCCCGTGGATTCTTGGCGCAAAAACTATGGAGAAAATGCTGACCTCAGCTTGGCCAAATCATCCATTTCTAATAACTAT
CTCAACCTCACATTTCCAAGGAAGAGGACTCCACGGGTGGATGGTCAAACCGGAGAGAATGACATGAACAAACGGAGACGGAAGGGCTTC
ACCAACCTGGACGAGGAAATACCAGAAATAGCCCACCACCCTACGGGTTTCATCTCTCACCAGAAGAAATGAGGAGACAGCGGCTTCACA
GATTCGATAGCCAGTGAGGTGGCATCTTGGGAAGACATGGCCTATTCGTGTAATTATTGCCCATTTGGCTCATTCCCCAAGCCCCTAATT
CATTTTAATTCATTTTAAACAAAAGCAGAGTACACCGGTATTGCTCCAGATCGCTCACATCACCTGGGACAGTCCCATGGCCCCTATGAG
TCAACTCACAGCTTGCGGGGAGTGGGCCTTCTCCTGGCCTTGTTCTTGCTCATAAACAGGTCACTTCCTCCATGAAGAGACCAGTTTCCA
CGCTCCCATCTCTCACTGCTGACTCAGCGATGCCTCTGCCTCGGTCTGCTTTTGAAGACTGTGACCTTCACCAGGAGGTTTTACTTACAC
CAGTCGGGAAGATTAGTCCCTCATTCTGCCTGGAGTGCCCCGTGTTTGACTTGGCAGCGGGTGTGGAGCCATCCCCGCGTCCTCCTGGCG
CATTGCCACTGTGGCTGTCCAGGAACAGGATGTGGCTGCCTTGGCCGAATGTTGTCCTACTCTCCCCAACCCCGGCGCCTCAGCTCCTCA
GCTCCTCGGGCCCCTGCGTCTGGCTGGTGTTTGCAGGGCTTTCGCTCTGCTCTGGTATTGCTCTGCCTTTATAGAAAGTCTTATTGAAGA
AGTGTAAGAAAGACCTAAGGTGGGGAAGACTCCTACACACACCATTAGTATCAGTGACACCAGCAATGTAGGTTCCCAGCCCCTTCCCAG
TGGCAGCTTGTGTGTCCAGGAGATAGGACATCATTTAACGCATCAGCAAAGTAGCAGCAGATGCCACATACAGAGTAGAGCGAAGGCATT
TGGTGGATCGGTCACTAGAGATCTATCTTGCAGAAAGTATGTTTTTCCTCATAAAAGTGCCTCTTAATTGGCCATTGTACCAGCCACTTG
TCCTAGCCAAATGTCCAAAACACGCCCTTGGGCCCCGCCACGTTACAATCCACAGATTGTCTGTCTGAGTCGTTTAAGGCATTTCCTGGT
GCTTGTGTTCCATGAATAAAAGGACAAAGTCAGAAGATCACTGATGTCTTACTGTCAACAGAGATATTTTAAAAGAGAGAAGCAGGAAAA
GATCTTCCTTTTTTGATCTACAACTTATATAGTTTTCTGATTATGCACATAATAGATATGCCTTCCAGATGCATAAGGCAAACATCTGGA
AAGAAATATACCCAAATCTTAGCAGGGGTTATCTTTGGGAGTGGAGTACATGGGATTTTGCTTTCTTCATTTTTATAATTTTATATTACT
GTCTTGGAAGATGTGTTTATGTGTGTGTGTTACTTTTACAATCAGGAAAACATATTTAATAACATATAGTCAAGAAAACAGACTTAAAAA
TAAATACTATGTGTCCATTGAGAAAATTCACAATATAAACAGAAATACAAATAAATACATACACAATTTTAAAGTCACCTGTAGCCCTAC
CCTTAGAGGTACCCAGGGTTAACATTTTGGTGGTATTGTCTTATCAATTTTTCCGTTGATACATTCAGCAAATTTGGAGCACATTGACCA
TGGAGTTTTGTGTCCAAATCCAATCTGAATTTACCTGGAAGAGGCCTTGACACCTGCATGGAAATGAGCTAAGAAAACCACTGGAGCCTT
GGGAGCTCTTTGGCCTCCTGGCTGGCCCAGTAATATCTGAGCTCCTTTGGTTAATTTATAACTGATATAAAACTACATCTTCTTTATAAT
ATAAATTGTACCTGTGAGTCTAGAAGCTTTAAATGTGTTTAAATTAAAATATTCAAGCTAAATGTTACTGCTCTCTCCCAAATTCTGTAA
GTTTGACTCCCGTTACCCCAATTAGAAGTAACTTCTTTGTTTCATGCCACTTTTATAGCATTTGGTAATTCTGCTATAACACATCTTGCC
CCTATTATTAACTGTGCACAGCTACACAAAGGTGTGCCTTCTACGTGGGAACATGGATTGTGAATGACTCTGTAATGAGGCCTGAGTCTT
AGTTATCTTTCCACTCACTCCCCGTCTCCCCTTTCCAACCCCAAAGGCTCACGATAGGGGCTCACTAAATGTCAGTGTTTCACCAAAGTA
TTTTTTCCATTGTATTAAGAGTCCAGTCACTGTATATGGAAGTATTTTATTTTTTATTTTTTTATATCACTTGAGTCCACTAGTAGTACT
TCCTTGCTCTGTTTGACTTGTCAGATACAAAGACACGGGATTAGATTTTGGGTGGTAAAATTGTGATACGCATGGCTGTTGATGGAGTGG
AACATCTTAGTGATGTGAGAAAGGTCATTTTAGTTATAAATGTAAACCAATTACTTTAGCACAACAATAAAGATGTTCTGGAAATTATTA
TAATTATTTTAGTTAATGGACTTGCCTGTAACAAGTGCTTATGTTTGGAATGTCCATTTTATTTTATTTTCCTCTACAATAAGGAATCCC
TAAAGTTATGCCAACAAACTGGAATTGGATTGAGAAAGACAAAAGCAAGTGAGCAAGTGTATTAGACTAATTATCTCTAGTAGGGAATAA
GCACTTAGAGCTAATTTTTTAATTTGGTTTATTTATTAGTAGCTCCCTGATTGTCTGTTAAGCCCCTGGTTCCCACAGTTTGGTGTGGTC
AGTCAACTTAAGCGACCTTTTAATGCAGAATCTTTACTTGGTTCTGAAGAGGAGGCAGTAGTTAAAATTGCTTCCTCTTAATGACTCTGA
ATGTATTGCCTGTGATTCCAAAGTTGTACATAATTGTTCAGACCTCCTCCATCCTTTTAAATTGCCTGCTGCAGTAAATAACTAGTTTGA
GTAGAACTAGATCCTGTCTATCTATTTGGCACATGTTCTGCTGCCTGGGGAGTAAGCAAGCTAAAGGGATGAGAAAGACCACCTCCCCCT
ACCCTGGAAATTGCACTGCAAGGCAGGGCGAGAATGGGGTAGCTGGCAGACCTGGCCTCCTTGTTCCCAGTCTTAGTTTTTCTTGAGAGA
TTCAGTATTCAGTAAAGAATAGCATTCAATTAGTCAAAAAATATATATATAACTTCTTCCTTTCCCTTCCCATGAATCATTGCAGTCATT
CCCTAAGTTTCTTCTCTTTTTTTTTCATGGCTGCTAGTATTTTATTTTAGAATCACAGACTCTCAGCTTAGAGAGTCACAGTATCTCAAT
TATTTGCTCTGTTCAATACTTAACAATACCTCCTCACTCAATTCTACATAACTCCAGCTTAGTCTTCCAAAATTCACTTTCATGATGCCA
CTCAGCATCTCAAATACCTTTCATTGGCTCTCTGCTGCCAAAGGATAAAGGTCAAAGTCATTAGCCTCAACAGTGGGCTTCAACCAGCCT
TTGGACCTCAGCCCCATTTATCCATCACAGAGGCTGGTAACTAGTCTCACTGCTCAGGCTGTGAGTGTTCCTGATCTTGTGACATTCTGT
GCTGTGCTTTTACATGGAACAGCTCTTTCCTCTCTCTTGGCCCATTCAGATCCTCCTCATCCAGCCCCCATCTGAATCCTGTAACAGACA
CAACCACATCTACACAGTTTCCACATACCACTTGGAATTGCTGGTTATGCTGCAATGAGAGAATGTCTTTGTCTTTAAATTGTAAGCTTC
ATGAGGGCAGGGACCATCTGTTTCTCTGTCTCTCCTCACAGTGCCTTGAGCAGTACGTTGTCTGGAATGTCAGAACCAATAAATACTTGT

>53509_53509_5_MICAL2-RHBDD1_MICAL2_chr11_12257792_ENST00000537344_RHBDD1_chr2_227860147_ENST00000341329_length(amino acids)=706AA_BP=688
MGENEDEKQAQAGQVFENFVQASTCKGTLQAFNILTRHLDLDPLDHRNFYSKLKSKVTTWKAKALWYKLDKRGSHKEYKRGKSCTNTKCL
IVGGGPCGLRTAIELAYLGAKVVVVEKRDSFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKVALMLGVEIHVN
VEFVKVLEPPEDQENQKIGWRAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAKVEEISGVAFIF
NQKFFQDLKEETGIDLENIVYYKDCTHYFVMTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDNLLSYAREAADFATNYQLPSLDFAMNH
YGQPDVAMFDFTCMYASENAALVRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWNQGTPPLELLAERESLYRLLPQ
TTPENINKNFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKELEHYPLERLGSVRRSVNLSRKESDIRPSKLLTWCQQQTEGYQHVNVTD
LTTSWRSGLALCAIIHRFRPELINFDSLNEDDAVENNQLAFDVAEREFGIPPVTTGKEMASAQEPDKLSMVMYLSKFYELFRGTPLRPVD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MICAL2-RHBDD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MICAL2-RHBDD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MICAL2-RHBDD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource